The chemotherapeutic agent DMXAA potently and specifically activates the TBK1-IRF-3 signaling axis

Journal of Experimental Medicine

Volumn 204, Issue 7, 2007, Pages 1559-1569

  Roberts, Zachary J ^a   Goutagny, Nadege ^b   Perera, Pin Yu ^c   Kato, Hiroki ^d   Kumar, Himanshu ^d   Kawai, Taro ^d   Akira, Shizuo ^d   Savan, Ram ^e   Van Echo, David ^e   Fitzgerald, Katherine A ^b   Young, Howard A ^e   Ching, Lai Ming ^f   Vogel, Stefanie N ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d OSAKA UNIVERSITY   (Japan)

^e NATIONAL CANCER INSTITUTE   (United States)

^f UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

5,6 DIMETHYLXANTHENONE 4 ACETIC ACID; ANTIINFECTIVE AGENT; BETA INTERFERON; HELICASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 3; INTERLEUKIN 1 RECEPTOR; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MYELOID DIFFERENTIATION FACTOR 88; PHOSPHOTRANSFERASE; SALICYLIC ACID; TANK BINDING KINASE 1; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CYTOSOL; DIMERIZATION; DRUG ACTIVATION; DRUG MECHANISM; DRUG POTENCY; EMBRYO; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; INTROSPECTION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; STIMULATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CELLS, CULTURED; CYTOKINES; DNA; ENHANCER ELEMENTS (GENETICS); FEMALE; GENE EXPRESSION REGULATION; IMMUNOGLOBULIN LIGHT CHAINS; INTERFERON REGULATORY FACTOR-3; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED C57BL; POLYMERASE CHAIN REACTION; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; XANTHONES;

EID: 34447330454     PISSN: 00221007     EISSN: 00221007     Source Type: Journal    
DOI: 10.1084/jem.20061845     Document Type: Article

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