메뉴 건너뛰기




Volumn 3, Issue 3, 2013, Pages 1282-1324

Myelin recovery in multiple sclerosis: The challenge of remyelination

Author keywords

Calpain; Central nervous system; Demyelination; Fingolimod; Glycolipids; Lipids; Multiple sclerosis; Myelin; Myelination; NKT cells; Oligodendrocytes; Remyelination; T cells

Indexed keywords

2', 3' CYCLIC NUCLEOTIDE 3' PHOSPHODIESTERASE; CALCIUM CHANNEL BLOCKING AGENT; CALPAIN; CALPASTATIN; CEREBROSIDE; CHOLESTEROL; CONNEXIN 32; CYTOKINE; FINGOLIMOD; FTY720 PHOSPHATE; GALACTOSYLCERAMIDE; GLUCOSYLCERAMIDE; IMMUNOGLOBULIN M ANTIBODY; INTEGRIN; LAMININ; LEUCINE RICH REPEAT AND IG DOMAIN CONTAINING 1; MEMBRANE PROTEIN; MYELIN ASSOCIATED GLYCOPROTEIN; MYELIN BASIC PROTEIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; NERVE CELL ADHESION MOLECULE; NERVE GROWTH FACTOR RECEPTOR; NOTCH RECEPTOR; PATTERN RECOGNITION RECEPTOR; PHOSPHATIDYLETHANOLAMINE; PHOSPHOLIPID; PROTEOLIPID PROTEIN; SPHINGOLIPID; UNCLASSIFIED DRUG;

EID: 85020519365     PISSN: None     EISSN: 20763425     Source Type: Journal    
DOI: 10.3390/brainsci3031282     Document Type: Review
Times cited : (99)

References (255)
  • 1
    • 33644607018 scopus 로고    scopus 로고
    • Multiple sclerosis-The plaque and its pathogenesis
    • Frohman, E.M.; Racke, M.K.; Raine, C.S. Multiple sclerosis-The plaque and its pathogenesis. N. Engl. J. Med. 2006, 354, 942-955.
    • (2006) N. Engl. J. Med , vol.354 , pp. 942-955
    • Frohman, E.M.1    Racke, M.K.2    Raine, C.S.3
  • 3
    • 0342906187 scopus 로고    scopus 로고
    • Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination
    • Lucchinetti, C.; Bruck, W.; Parisi, J.; Scheithauer, B.; Rodriguez, M.; Lassmann, H. Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination. Ann. Neurol. 2000, 47, 707-717.
    • (2000) Ann. Neurol , vol.47 , pp. 707-717
    • Lucchinetti, C.1    Bruck, W.2    Parisi, J.3    Scheithauer, B.4    Rodriguez, M.5    Lassmann, H.6
  • 4
    • 84864434405 scopus 로고    scopus 로고
    • Oligodendrocytes and the early multiple sclerosis lesion
    • Prineas, J.W.; Parratt, J.D. Oligodendrocytes and the early multiple sclerosis lesion. Ann. Neurol. 2012, 72, 18-31.
    • (2012) Ann. Neurol , vol.72 , pp. 18-31
    • Prineas, J.W.1    Parratt, J.D.2
  • 5
    • 0036720034 scopus 로고    scopus 로고
    • Why does remyelination fail in multiple sclerosis?
    • Franklin, R.J. Why does remyelination fail in multiple sclerosis? Nat. Rev. Neurosci. 2002, 3, 705-714.
    • (2002) Nat. Rev. Neurosci , vol.3 , pp. 705-714
    • Franklin, R.J.1
  • 7
    • 77951073508 scopus 로고    scopus 로고
    • Mechanism of action of oral fingolimod (FTY720) in multiple sclerosis
    • Chun, J.; Hartung, H.P. Mechanism of action of oral fingolimod (FTY720) in multiple sclerosis. Clin. Neuropharmacol. 2010, 33, 91-101.
    • (2010) Clin. Neuropharmacol , vol.33 , pp. 91-101
    • Chun, J.1    Hartung, H.P.2
  • 8
    • 84875232446 scopus 로고    scopus 로고
    • The mechanism of action of glatiramer acetate in multiple sclerosis and beyond
    • Aharoni, R. The mechanism of action of glatiramer acetate in multiple sclerosis and beyond. Autoimmun. Rev. 2013, 12, 543-553.
    • (2013) Autoimmun. Rev , vol.12 , pp. 543-553
    • Aharoni, R.1
  • 9
    • 45349095327 scopus 로고    scopus 로고
    • The self-organization of lipids and proteins of myelin at the membrane interface. Molecular factors underlying the microheterogeneity of domain segregation
    • Rosetti, C.M.; Maggio, B.; Oliveira, R.G. The self-organization of lipids and proteins of myelin at the membrane interface. Molecular factors underlying the microheterogeneity of domain segregation. Biochim. Biophys. Acta 2008, 1778, 1665-1675.
    • (2008) Biochim. Biophys. Acta , vol.1778 , pp. 1665-1675
    • Rosetti, C.M.1    Maggio, B.2    Oliveira, R.G.3
  • 10
    • 0013897855 scopus 로고
    • The lipid composition of purified bovine brain myelin
    • Norton, W.T.; Autilio, L.A. The lipid composition of purified bovine brain myelin. J. Neurochem. 1966, 13, 213-222.
    • (1966) J. Neurochem , vol.13 , pp. 213-222
    • Norton, W.T.1    Autilio, L.A.2
  • 11
    • 0017143881 scopus 로고
    • Lipid composition of myelin in multiple sclerosis
    • Fewster, M.E.; Hirono, H.; Mead, J.F. Lipid composition of myelin in multiple sclerosis. J. Neurol. 1976, 213, 119-131.
    • (1976) J. Neurol , vol.213 , pp. 119-131
    • Fewster, M.E.1    Hirono, H.2    Mead, J.F.3
  • 12
    • 0036244882 scopus 로고    scopus 로고
    • 3-O-acetyl-sphingosine-series myelin glycolipids: Characterization of novel 3-O-acetyl-sphingosine galactosylceramide
    • Dasgupta, S.; Levery, S.B.; Hogan, E.L. 3-O-acetyl-sphingosine-series myelin glycolipids: Characterization of novel 3-O-acetyl-sphingosine galactosylceramide. J. Lipid Res. 2002, 43, 751-761.
    • (2002) J. Lipid Res , vol.43 , pp. 751-761
    • Dasgupta, S.1    Levery, S.B.2    Hogan, E.L.3
  • 14
    • 77952682102 scopus 로고    scopus 로고
    • Novel myelin penta- and hexa-acetyl-galactosyl-ceramides: Structural characterization and immunoreactivity in cerebrospinal fluid
    • Podbielska, M.; Dasgupta, S.; Levery, S.B.; Tourtellotte, W.W.; Annuk, H.; Moran, A.P.; Hogan, E.L. Novel myelin penta- and hexa-acetyl-galactosyl-ceramides: Structural characterization and immunoreactivity in cerebrospinal fluid. J. Lipid Res. 2010, 51, 1394-1406.
    • (2010) J. Lipid Res , vol.51 , pp. 1394-1406
    • Podbielska, M.1    Dasgupta, S.2    Levery, S.B.3    Tourtellotte, W.W.4    Annuk, H.5    Moran, A.P.6    Hogan, E.L.7
  • 15
    • 0015488013 scopus 로고
    • Gangliosides of human, bovine, and rabbit plasma
    • Yu, R.K.; Ledeen, R.W. Gangliosides of human, bovine, and rabbit plasma. J. Lipid Res. 1972, 13, 680-686.
    • (1972) J. Lipid Res , vol.13 , pp. 680-686
    • Yu, R.K.1    Ledeen, R.W.2
  • 16
    • 52049097749 scopus 로고    scopus 로고
    • Cholesterol domains in cationic lipid/DNA complexes improve transfection
    • Xu, L.; Anchordoquy, T.J. Cholesterol domains in cationic lipid/DNA complexes improve transfection. Biochim. Biophys. Acta 2008, 1778, 2177-2181.
    • (2008) Biochim. Biophys. Acta , vol.1778 , pp. 2177-2181
    • Xu, L.1    Anchordoquy, T.J.2
  • 18
    • 55749104704 scopus 로고    scopus 로고
    • A defect of sphingolipid metabolism modifies the properties of normal appearing white matter in multiple sclerosis
    • Wheeler, D.; Bandaru, V.V.; Calabresi, P.A.; Nath, A.; Haughey, N.J. A defect of sphingolipid metabolism modifies the properties of normal appearing white matter in multiple sclerosis. Brain 2008, 131, 3092-3102.
    • (2008) Brain , vol.131 , pp. 3092-3102
    • Wheeler, D.1    Bandaru, V.V.2    Calabresi, P.A.3    Nath, A.4    Haughey, N.J.5
  • 19
    • 69149108015 scopus 로고    scopus 로고
    • Molecular and immunogenic features of myelin lipids: Incitants or modulators of multiple sclerosis?
    • Podbielska, M.; Hogan, E.L. Molecular and immunogenic features of myelin lipids: Incitants or modulators of multiple sclerosis? Mult. Scler. 2009, 15, 1011-1029.
    • (2009) Mult. Scler , vol.15 , pp. 1011-1029
    • Podbielska, M.1    Hogan, E.L.2
  • 20
    • 79953815595 scopus 로고    scopus 로고
    • The structural and functional role of myelin fast-migrating cerebrosides: Pathological importance in multiple sclerosis
    • Podbielska, M.; Levery, S.B.; Hogan, E.L. The structural and functional role of myelin fast-migrating cerebrosides: Pathological importance in multiple sclerosis. Clin. Lipidol. 2011, 6, 159-179.
    • (2011) Clin. Lipidol , vol.6 , pp. 159-179
    • Podbielska, M.1    Levery, S.B.2    Hogan, E.L.3
  • 21
    • 0034702121 scopus 로고    scopus 로고
    • Induction of neurogenesis in the neocortex of adult mice
    • Magavi, S.S.; Leavitt, B.R.; Macklis, J.D. Induction of neurogenesis in the neocortex of adult mice. Nature 2000, 405, 951-955.
    • (2000) Nature , vol.405 , pp. 951-955
    • Magavi, S.S.1    Leavitt, B.R.2    Macklis, J.D.3
  • 23
    • 0027164472 scopus 로고
    • Oligodendrocyte precursors originate at the ventral ventricular zone dorsal to the ventral midline region in the embryonic rat spinal cord
    • Noll, E.; Miller, R.H. Oligodendrocyte precursors originate at the ventral ventricular zone dorsal to the ventral midline region in the embryonic rat spinal cord. Development 1993, 118, 563-573.
    • (1993) Development , vol.118 , pp. 563-573
    • Noll, E.1    Miller, R.H.2
  • 24
    • 0032077929 scopus 로고    scopus 로고
    • Dorsal spinal cord neuroepithelium generates astrocytes but not oligodendrocytes
    • Pringle, N.P.; Guthrie, S.; Lumsden, A.; Richardson, W.D. Dorsal spinal cord neuroepithelium generates astrocytes but not oligodendrocytes. Neuron 1998, 20, 883-893.
    • (1998) Neuron , vol.20 , pp. 883-893
    • Pringle, N.P.1    Guthrie, S.2    Lumsden, A.3    Richardson, W.D.4
  • 25
    • 0036333452 scopus 로고    scopus 로고
    • Dual origin of spinal oligodendrocyte progenitors and evidence for the cooperative role of Olig2 and Nkx2.2 in the control of oligodendrocyte differentiation
    • Fu, H.; Qi, Y.; Tan, M.; Cai, J.; Takebayashi, H.; Nakafuku, M.; Richardson, W.; Qiu, M. Dual origin of spinal oligodendrocyte progenitors and evidence for the cooperative role of Olig2 and Nkx2.2 in the control of oligodendrocyte differentiation. Development 2002, 129, 681-693.
    • (2002) Development , vol.129 , pp. 681-693
    • Fu, H.1    Qi, Y.2    Tan, M.3    Cai, J.4    Takebayashi, H.5    Nakafuku, M.6    Richardson, W.7    Qiu, M.8
  • 26
    • 11344277387 scopus 로고    scopus 로고
    • Generation of oligodendrocyte precursor cells from mouse dorsal spinal cord independent of Nkx6 regulation and Shh signaling
    • Cai, J.; Qi, Y.; Hu, X.; Tan, M.; Liu, Z.; Zhang, J.; Li, Q.; Sander, M.; Qiu, M. Generation of oligodendrocyte precursor cells from mouse dorsal spinal cord independent of Nkx6 regulation and Shh signaling. Neuron 2005, 45, 41-53.
    • (2005) Neuron , vol.45 , pp. 41-53
    • Cai, J.1    Qi, Y.2    Hu, X.3    Tan, M.4    Liu, Z.5    Zhang, J.6    Li, Q.7    Sander, M.8    Qiu, M.9
  • 27
    • 11344261775 scopus 로고    scopus 로고
    • Multiple dorsoventral origins of oligodendrocyte generation in the spinal cord and hindbrain
    • Vallstedt, A.; Klos, J.M.; Ericson, J. Multiple dorsoventral origins of oligodendrocyte generation in the spinal cord and hindbrain. Neuron 2005, 45, 55-67.
    • (2005) Neuron , vol.45 , pp. 55-67
    • Vallstedt, A.1    Klos, J.M.2    Ericson, J.3
  • 28
    • 31544442467 scopus 로고    scopus 로고
    • Competing waves of oligodendrocytes in the forebrain and postnatal elimination of an embryonic lineage
    • Kessaris, N.; Fogarty, M.; Iannarelli, P.; Grist, M.; Wegner, M.; Richardson, W.D. Competing waves of oligodendrocytes in the forebrain and postnatal elimination of an embryonic lineage. Nat. Neurosci. 2006, 9, 173-179.
    • (2006) Nat. Neurosci , vol.9 , pp. 173-179
    • Kessaris, N.1    Fogarty, M.2    Iannarelli, P.3    Grist, M.4    Wegner, M.5    Richardson, W.D.6
  • 29
    • 0036861534 scopus 로고    scopus 로고
    • Bone morphogenetic proteins negatively control oligodendrocyte precursor specification in the chick spinal cord
    • Mekki-Dauriac, S.; Agius, E.; Kan, P.; Cochard, P. Bone morphogenetic proteins negatively control oligodendrocyte precursor specification in the chick spinal cord. Development 2002, 129, 5117-5130.
    • (2002) Development , vol.129 , pp. 5117-5130
    • Mekki-Dauriac, S.1    Agius, E.2    Kan, P.3    Cochard, P.4
  • 31
    • 0028153896 scopus 로고
    • + glial precursors in the developing rat spinal cord
    • + glial precursors in the developing rat spinal cord. J. Neurosci. Res. 1994, 37, 219-235.
    • (1994) J. Neurosci. Res , vol.37 , pp. 219-235
    • Fok-Seang, J.1    Miller, R.H.2
  • 33
    • 0035066639 scopus 로고    scopus 로고
    • Biology of oligodendrocyte and myelin in the mammalian central nervous system
    • Baumann, N.; Pham-Dinh, D. Biology of oligodendrocyte and myelin in the mammalian central nervous system. Physiol. Rev. 2001, 81, 871-927.
    • (2001) Physiol. Rev , vol.81 , pp. 871-927
    • Baumann, N.1    Pham-Dinh, D.2
  • 34
    • 0036669540 scopus 로고    scopus 로고
    • Regulation of oligodendrocyte development in the vertebrate CNS
    • Miller, R.H. Regulation of oligodendrocyte development in the vertebrate CNS. Prog. Neurobiol.2002, 67, 451-467.
    • (2002) Prog. Neurobiol , vol.67 , pp. 451-467
    • Miller, R.H.1
  • 35
    • 0035291278 scopus 로고    scopus 로고
    • NG2 cells in the brain: A novel glial cell population
    • Nishiyama, A. NG2 cells in the brain: A novel glial cell population. Hum. Cell 2001, 14, 77-82.
    • (2001) Hum. Cell , vol.14 , pp. 77-82
    • Nishiyama, A.1
  • 36
    • 0142250835 scopus 로고    scopus 로고
    • NG2-expressing glial progenitor cells: An abundant and widespread population of cycling cells in the adult rat CNS
    • Dawson, M.R.; Polito, A.; Levine, J.M.; Reynolds, R. NG2-expressing glial progenitor cells: An abundant and widespread population of cycling cells in the adult rat CNS. Mol. Cell. Neurosci. 2003, 24, 476-488.
    • (2003) Mol. Cell. Neurosci , vol.24 , pp. 476-488
    • Dawson, M.R.1    Polito, A.2    Levine, J.M.3    Reynolds, R.4
  • 38
    • 79958828794 scopus 로고    scopus 로고
    • Regenerative medicine in multiple sclerosis: Identifying pharmacological targets of adult neural stem cell differentiation
    • Huang, J.K.; Franklin, R.J. Regenerative medicine in multiple sclerosis: Identifying pharmacological targets of adult neural stem cell differentiation. Neurochem. Int. 2011, 59, 329-332.
    • (2011) Neurochem. Int , vol.59 , pp. 329-332
    • Huang, J.K.1    Franklin, R.J.2
  • 39
    • 0027193569 scopus 로고
    • The oligodendrocyte and its many cellular processes
    • Pfeiffer, S.E.; Warrington, A.E.; Bansal, R. The oligodendrocyte and its many cellular processes. Trends Cell Biol. 1993, 3, 191-197.
    • (1993) Trends Cell Biol , vol.3 , pp. 191-197
    • Pfeiffer, S.E.1    Warrington, A.E.2    Bansal, R.3
  • 41
    • 0019791655 scopus 로고
    • Turnover rate of molecular species of sphingomyelin in rat brain
    • LeBaron, F.N.; Sanyal, S.; Jungalwala, F.B. Turnover rate of molecular species of sphingomyelin in rat brain. Neurochem. Res. 1981, 6, 1081-1089.
    • (1981) Neurochem. Res , vol.6 , pp. 1081-1089
    • Lebaron, F.N.1    Sanyal, S.2    Jungalwala, F.B.3
  • 43
    • 33751514940 scopus 로고    scopus 로고
    • Neuron-glia communication in the control of oligodendrocyte function and myelin biogenesis
    • Simons, M.; Trajkovic, K. Neuron-glia communication in the control of oligodendrocyte function and myelin biogenesis. J. Cell Sci. 2006, 119, 4381-4389.
    • (2006) J. Cell Sci , vol.119 , pp. 4381-4389
    • Simons, M.1    Trajkovic, K.2
  • 45
    • 77955126878 scopus 로고    scopus 로고
    • Axon-oligodendrocyte interactions during developmental myelination, demyelination and repair
    • Piaton, G.; Gould, R.M.; Lubetzki, C. Axon-oligodendrocyte interactions during developmental myelination, demyelination and repair. J. Neurochem. 2010, 114, 1243-1260.
    • (2010) J. Neurochem , vol.114 , pp. 1243-1260
    • Piaton, G.1    Gould, R.M.2    Lubetzki, C.3
  • 46
    • 0020111157 scopus 로고
    • Rat optic nerve: Electrophysiological, pharmacological and anatomical studies during development
    • Foster, R.E.; Connors, B.W.; Waxman, S.G. Rat optic nerve: Electrophysiological, pharmacological and anatomical studies during development. Brain Res. 1982, 255, 371-386.
    • (1982) Brain Res , vol.255 , pp. 371-386
    • Foster, R.E.1    Connors, B.W.2    Waxman, S.G.3
  • 47
    • 0024465771 scopus 로고
    • Target size regulates calibre and myelination of sympathetic axons
    • Voyvodic, J.T. Target size regulates calibre and myelination of sympathetic axons. Nature 1989, 342, 430-433.
    • (1989) Nature , vol.342 , pp. 430-433
    • Voyvodic, J.T.1
  • 48
    • 0015297040 scopus 로고
    • Control of myelin formation by axon caliber (with a model of the control mechanism)
    • Friede, R.L. Control of myelin formation by axon caliber (with a model of the control mechanism). J. Comp. Neurol. 1972, 144, 233-252.
    • (1972) J. Comp. Neurol , vol.144 , pp. 233-252
    • Friede, R.L.1
  • 50
    • 66049119910 scopus 로고    scopus 로고
    • Cholesterol regulates the endoplasmic reticulum exit of the major membrane protein P0 required for peripheral myelin compaction
    • Saher, G.; Quintes, S.; Mobius, W.; Wehr, M.C.; Kramer-Albers, E.M.; Brugger, B.; Nave, K.A. Cholesterol regulates the endoplasmic reticulum exit of the major membrane protein P0 required for peripheral myelin compaction. J. Neurosci. 2009, 29, 6094-6104.
    • (2009) J. Neurosci , vol.29 , pp. 6094-6104
    • Saher, G.1    Quintes, S.2    Mobius, W.3    Wehr, M.C.4    Kramer-Albers, E.M.5    Brugger, B.6    Nave, K.A.7
  • 55
    • 33646253436 scopus 로고    scopus 로고
    • Remyelination of dorsal column axons by endogenous Schwann cells restores the normal pattern of Nav1.6 and Kv1.2 at nodes of Ranvier
    • Black, J.A.; Waxman, S.G.; Smith, K.J. Remyelination of dorsal column axons by endogenous Schwann cells restores the normal pattern of Nav1.6 and Kv1.2 at nodes of Ranvier. Brain 2006, 129, 1319-1329.
    • (2006) Brain , vol.129 , pp. 1319-1329
    • Black, J.A.1    Waxman, S.G.2    Smith, K.J.3
  • 57
    • 80052104308 scopus 로고    scopus 로고
    • Wallerian degeneration: The innate-immune response to traumatic nerve injury
    • Rotshenker, S. Wallerian degeneration: The innate-immune response to traumatic nerve injury. J. Neuroinflamm. 2011, 8, 109.
    • (2011) J. Neuroinflamm , vol.8 , pp. 109
    • Rotshenker, S.1
  • 59
    • 53049085062 scopus 로고    scopus 로고
    • Mechanisms of inflammation induced tissue injury in multiple sclerosis
    • Lassmann, H. Mechanisms of inflammation induced tissue injury in multiple sclerosis. J. Neurol. Sci. 2008, 274, 45-47.
    • (2008) J. Neurol. Sci , vol.274 , pp. 45-47
    • Lassmann, H.1
  • 61
    • 33745631754 scopus 로고    scopus 로고
    • Antigen presentation in autoimmunity and CNS inflammation: How T lymphocytes recognize the brain
    • Becher, B.; Bechmann, I.; Greter, M. Antigen presentation in autoimmunity and CNS inflammation: How T lymphocytes recognize the brain. J. Mol. Med. 2006, 84, 532-543.
    • (2006) J. Mol. Med , vol.84 , pp. 532-543
    • Becher, B.1    Bechmann, I.2    Greter, M.3
  • 62
    • 0344791683 scopus 로고    scopus 로고
    • Endocytic sorting of lipid analogues differing solely in the chemistry of their hydrophobic tails
    • Mukherjee, S.; Soe, T.T.; Maxfield, F.R. Endocytic sorting of lipid analogues differing solely in the chemistry of their hydrophobic tails. J. Cell Biol. 1999, 144, 1271-1284.
    • (1999) J. Cell Biol , vol.144 , pp. 1271-1284
    • Mukherjee, S.1    Soe, T.T.2    Maxfield, F.R.3
  • 63
    • 0034157389 scopus 로고    scopus 로고
    • Role of membrane organization and membrane domains in endocytic lipid trafficking
    • Mukherjee, S.; Maxfield, F.R. Role of membrane organization and membrane domains in endocytic lipid trafficking. Traffic 2000, 1, 203-211.
    • (2000) Traffic , vol.1 , pp. 203-211
    • Mukherjee, S.1    Maxfield, F.R.2
  • 64
    • 0031227791 scopus 로고    scopus 로고
    • Assembly and retention of CD1b heavy chains in the endoplasmic reticulum
    • Sugita, M.; Porcelli, S.A.; Brenner, M.B. Assembly and retention of CD1b heavy chains in the endoplasmic reticulum. J. Immunol. 1997, 159, 2358-2365.
    • (1997) J. Immunol , vol.159 , pp. 2358-2365
    • Sugita, M.1    Porcelli, S.A.2    Brenner, M.B.3
  • 69
    • 0029939467 scopus 로고    scopus 로고
    • Multiple sclerosis: A coordinated immunological attack against myelin in the central nervous system
    • Steinman, L. Multiple sclerosis: A coordinated immunological attack against myelin in the central nervous system. Cell 1996, 85, 299-302.
    • (1996) Cell , vol.85 , pp. 299-302
    • Steinman, L.1
  • 70
    • 23744475685 scopus 로고    scopus 로고
    • The ins and outs of T-lymphocyte trafficking to the CNS: Anatomical sites and molecular mechanisms
    • Engelhardt, B.; Ransohoff, R.M. The ins and outs of T-lymphocyte trafficking to the CNS: Anatomical sites and molecular mechanisms. Trends Immunol. 2005, 26, 485-495.
    • (2005) Trends Immunol , vol.26 , pp. 485-495
    • Engelhardt, B.1    Ransohoff, R.M.2
  • 71
    • 0036687120 scopus 로고    scopus 로고
    • Functional expression of the lymphoid chemokines CCL19 (ELC) and CCL 21 (SLC) at the blood-brain barrier suggests their involvement in G-protein-dependent lymphocyte recruitment into the central nervous system during experimental autoimmune encephalomyelitis
    • Alt, C.; Laschinger, M.; Engelhardt, B. Functional expression of the lymphoid chemokines CCL19 (ELC) and CCL 21 (SLC) at the blood-brain barrier suggests their involvement in G-protein-dependent lymphocyte recruitment into the central nervous system during experimental autoimmune encephalomyelitis. Eur. J. Immunol. 2002, 32, 2133-2144.
    • (2002) Eur. J. Immunol , vol.32 , pp. 2133-2144
    • Alt, C.1    Laschinger, M.2    Engelhardt, B.3
  • 72
    • 0037248807 scopus 로고    scopus 로고
    • Lymphoid chemokines CCL19 and CCL21 are expressed in the central nervous system during experimental autoimmune encephalomyelitis: Implications for the maintenance of chronic neuroinflammation
    • Columba-Cabezas, S.; Serafini, B.; Ambrosini, E.; Aloisi, F. Lymphoid chemokines CCL19 and CCL21 are expressed in the central nervous system during experimental autoimmune encephalomyelitis: Implications for the maintenance of chronic neuroinflammation. Brain Pathol. 2003, 13, 38-51.
    • (2003) Brain Pathol , vol.13 , pp. 38-51
    • Columba-Cabezas, S.1    Serafini, B.2    Ambrosini, E.3    Aloisi, F.4
  • 74
    • 0028785417 scopus 로고
    • Distinct roles for B7-1 (CD-80) and B7-2 (CD-86) in the initiation of experimental allergic encephalomyelitis
    • Racke, M.K.; Scott, D.E.; Quigley, L.; Gray, G.S.; Abe, R.; June, C.H.; Perrin, P.J. Distinct roles for B7-1 (CD-80) and B7-2 (CD-86) in the initiation of experimental allergic encephalomyelitis. J. Clin. Investig. 1995, 96, 2195-2203.
    • (1995) J. Clin. Investig , vol.96 , pp. 2195-2203
    • Racke, M.K.1    Scott, D.E.2    Quigley, L.3    Gray, G.S.4    Abe, R.5    June, C.H.6    Perrin, P.J.7
  • 75
    • 0033083303 scopus 로고    scopus 로고
    • Blocking OX-40/OX-40 ligand interaction in vitro and in vivo leads to decreased T cell function and amelioration of experimental allergic encephalomyelitis
    • Weinberg, A.D.; Wegmann, K.W.; Funatake, C.; Whitham, R.H. Blocking OX-40/OX-40 ligand interaction in vitro and in vivo leads to decreased T cell function and amelioration of experimental allergic encephalomyelitis. J. Immunol. 1999, 162, 1818-1826.
    • (1999) J. Immunol , vol.162 , pp. 1818-1826
    • Weinberg, A.D.1    Wegmann, K.W.2    Funatake, C.3    Whitham, R.H.4
  • 76
    • 0037481891 scopus 로고    scopus 로고
    • Changes in the expression and localization of the paranodal protein Caspr on axons in chronic multiple sclerosis
    • Wolswijk, G.; Balesar, R. Changes in the expression and localization of the paranodal protein Caspr on axons in chronic multiple sclerosis. Brain 2003, 126, 1638-1649.
    • (2003) Brain , vol.126 , pp. 1638-1649
    • Wolswijk, G.1    Balesar, R.2
  • 77
    • 33751208544 scopus 로고    scopus 로고
    • Nodal, paranodal and juxtaparanodal axonal proteins during demyelination and remyelination in multiple sclerosis
    • Coman, I.; Aigrot, M.S.; Seilhean, D.; Reynolds, R.; Girault, J.A.; Zalc, B.; Lubetzki, C. Nodal, paranodal and juxtaparanodal axonal proteins during demyelination and remyelination in multiple sclerosis. Brain 2006, 129, 3186-3195.
    • (2006) Brain , vol.129 , pp. 3186-3195
    • Coman, I.1    Aigrot, M.S.2    Seilhean, D.3    Reynolds, R.4    Girault, J.A.5    Zalc, B.6    Lubetzki, C.7
  • 78
    • 33845312662 scopus 로고    scopus 로고
    • Disruption of neurofascin localization reveals early changes preceding demyelination and remyelination in multiple sclerosis
    • Howell, O.W.; Palser, A.; Polito, A.; Melrose, S.; Zonta, B.; Scheiermann, C.; Vora, A.J.; Brophy, P.J.; Reynolds, R. Disruption of neurofascin localization reveals early changes preceding demyelination and remyelination in multiple sclerosis. Brain 2006, 129, 3173-3185.
    • (2006) Brain , vol.129 , pp. 3173-3185
    • Howell, O.W.1    Palser, A.2    Polito, A.3    Melrose, S.4    Zonta, B.5    Scheiermann, C.6    Vora, A.J.7    Brophy, P.J.8    Reynolds, R.9
  • 79
    • 48249139449 scopus 로고    scopus 로고
    • Multiple sclerosis: An immune or neurodegenerative disorder
    • Trapp, B.D.; Nave, K.A. Multiple sclerosis: An immune or neurodegenerative disorder? Annu. Rev. Neurosci. 2008, 31, 247-269.
    • (2008) Annu. Rev. Neurosci , vol.31 , pp. 247-269
    • Trapp, B.D.1    Nave, K.A.2
  • 81
    • 24744435759 scopus 로고    scopus 로고
    • Neurogenesis and neuroprotection induced by peripheral immunomodulatory treatment of experimental autoimmune encephalomyelitis
    • Aharoni, R.; Arnon, R.; Eilam, R. Neurogenesis and neuroprotection induced by peripheral immunomodulatory treatment of experimental autoimmune encephalomyelitis. J. Neurosci. 2005, 25, 8217-8228.
    • (2005) J. Neurosci , vol.25 , pp. 8217-8228
    • Aharoni, R.1    Arnon, R.2    Eilam, R.3
  • 82
    • 33748420494 scopus 로고    scopus 로고
    • Effects of commissural de- and remyelination on motor skill behaviour in the cuprizone mouse model of multiple sclerosis
    • Liebetanz, D.; Merkler, D. Effects of commissural de- and remyelination on motor skill behaviour in the cuprizone mouse model of multiple sclerosis. Exp. Neurol. 2006, 202, 217-224.
    • (2006) Exp. Neurol , vol.202 , pp. 217-224
    • Liebetanz, D.1    Merkler, D.2
  • 83
    • 33745030164 scopus 로고    scopus 로고
    • Histological and ultrastructural analysis of white matter damage after naturally-occurring spinal cord injury
    • Smith, P.M.; Jeffery, N.D. Histological and ultrastructural analysis of white matter damage after naturally-occurring spinal cord injury. Brain Pathol. 2006, 16, 99-109.
    • (2006) Brain Pathol , vol.16 , pp. 99-109
    • Smith, P.M.1    Jeffery, N.D.2
  • 85
    • 2342550089 scopus 로고    scopus 로고
    • Chronic nerve compression induces local demyelination and remyelination in a rat model of carpal tunnel syndrome
    • Gupta, R.; Rowshan, K.; Chao, T.; Mozaffar, T.; Steward, O. Chronic nerve compression induces local demyelination and remyelination in a rat model of carpal tunnel syndrome. Exp. Neurol. 2004, 187, 500-508.
    • (2004) Exp. Neurol , vol.187 , pp. 500-508
    • Gupta, R.1    Rowshan, K.2    Chao, T.3    Mozaffar, T.4    Steward, O.5
  • 86
    • 0027173943 scopus 로고
    • Multiple sclerosis: Remyelination in acute lesions
    • Raine, C.S.; Wu, E. Multiple sclerosis: Remyelination in acute lesions. J. Neuropathol. Exp. Neurol. 1993, 52, 199-204.
    • (1993) J. Neuropathol. Exp. Neurol , vol.52 , pp. 199-204
    • Raine, C.S.1    Wu, E.2
  • 87
    • 84857769209 scopus 로고    scopus 로고
    • Multiple sclerosis-Remyelination failure as a cause of disease progression
    • Hagemeier, K.; Bruck, W.; Kuhlmann, T. Multiple sclerosis-Remyelination failure as a cause of disease progression. Histol. Histopathol. 2012, 27, 277-287.
    • (2012) Histol. Histopathol , vol.27 , pp. 277-287
    • Hagemeier, K.1    Bruck, W.2    Kuhlmann, T.3
  • 88
    • 61749099508 scopus 로고    scopus 로고
    • Abnormal expression of TIP30 and arrested nucleocytoplasmic transport within oligodendrocyte precursor cells in multiple sclerosis
    • Nakahara, J.; Kanekura, K.; Nawa, M.; Aiso, S.; Suzuki, N. Abnormal expression of TIP30 and arrested nucleocytoplasmic transport within oligodendrocyte precursor cells in multiple sclerosis. J. Clin. Invest. 2009, 119, 169-181.
    • (2009) J. Clin. Invest , vol.119 , pp. 169-181
    • Nakahara, J.1    Kanekura, K.2    Nawa, M.3    Aiso, S.4    Suzuki, N.5
  • 90
    • 0018410045 scopus 로고
    • Remyelination in multiple sclerosis
    • Prineas, J.W.; Connell, F. Remyelination in multiple sclerosis. Ann. Neurol. 1979, 5, 22-31.
    • (1979) Ann. Neurol , vol.5 , pp. 22-31
    • Prineas, J.W.1    Connell, F.2
  • 91
    • 0030860443 scopus 로고    scopus 로고
    • A combined inhibitor of matrix metalloproteinase activity and tumour necrosis factor-α processing attenuates experimental autoimmune neuritis
    • Redford, E.J.; Smith, K.J.; Gregson, N.A.; Davies, M.; Hughes, P.; Gearing, A.J.; Miller, K.; Hughes, R.A. A combined inhibitor of matrix metalloproteinase activity and tumour necrosis factor-α processing attenuates experimental autoimmune neuritis. Brain 1997, 120, 1895-1905.
    • (1997) Brain , vol.120 , pp. 1895-1905
    • Redford, E.J.1    Smith, K.J.2    Gregson, N.A.3    Davies, M.4    Hughes, P.5    Gearing, A.J.6    Miller, K.7    Hughes, R.A.8
  • 93
    • 0033152830 scopus 로고    scopus 로고
    • GDNF family members and their receptors: Expression and functions in two oligodendroglial cell lines representing distinct stages of oligodendroglial development
    • Strelau, J.; Unsicker, K. GDNF family members and their receptors: Expression and functions in two oligodendroglial cell lines representing distinct stages of oligodendroglial development. Glia 1999, 26, 291-301.
    • (1999) Glia , vol.26 , pp. 291-301
    • Strelau, J.1    Unsicker, K.2
  • 94
    • 0034794081 scopus 로고    scopus 로고
    • A role for oligodendrocyte-derived IGF-1 in trophic support of cortical neurons
    • Wilkins, A.; Chandran, S.; Compston, A. A role for oligodendrocyte-derived IGF-1 in trophic support of cortical neurons. Glia 2001, 36, 48-57.
    • (2001) Glia , vol.36 , pp. 48-57
    • Wilkins, A.1    Chandran, S.2    Compston, A.3
  • 95
    • 0030063699 scopus 로고    scopus 로고
    • Co-localization of NG2 proteoglycan and PDGF α-receptor on O2A progenitor cells in the developing rat brain
    • Nishiyama, A.; Lin, X.H.; Giese, N.; Heldin, C.H.; Stallcup, W.B. Co-localization of NG2 proteoglycan and PDGF α-receptor on O2A progenitor cells in the developing rat brain. J. Neurosci. Res. 1996, 43, 299-314.
    • (1996) J. Neurosci. Res , vol.43 , pp. 299-314
    • Nishiyama, A.1    Lin, X.H.2    Giese, N.3    Heldin, C.H.4    Stallcup, W.B.5
  • 96
    • 0026689059 scopus 로고
    • PDGF receptors in the rat CNS: During late neurogenesis, PDGF α-receptor expression appears to be restricted to glial cells of the oligodendrocyte lineage
    • Pringle, N.P.; Mudhar, H.S.; Collarini, E.J.; Richardson, W.D. PDGF receptors in the rat CNS: During late neurogenesis, PDGF α-receptor expression appears to be restricted to glial cells of the oligodendrocyte lineage. Development 1992, 115, 535-551.
    • (1992) Development , vol.115 , pp. 535-551
    • Pringle, N.P.1    Mudhar, H.S.2    Collarini, E.J.3    Richardson, W.D.4
  • 97
    • 33646251131 scopus 로고    scopus 로고
    • Innate immunity triggers oligodendrocyte progenitor reactivity and confines damages to brain injuries
    • Glezer, I.; Lapointe, A.; Rivest, S. Innate immunity triggers oligodendrocyte progenitor reactivity and confines damages to brain injuries. FASEB J. 2006, 20, 750-752.
    • (2006) FASEB J , vol.20 , pp. 750-752
    • Glezer, I.1    Lapointe, A.2    Rivest, S.3
  • 98
    • 33646348133 scopus 로고    scopus 로고
    • The injury response of oligodendrocyte precursor cells is induced by platelets, macrophages and inflammation-associated cytokines
    • Rhodes, K.E.; Raivich, G.; Fawcett, J.W. The injury response of oligodendrocyte precursor cells is induced by platelets, macrophages and inflammation-associated cytokines. Neuroscience 2006, 140, 87-100.
    • (2006) Neuroscience , vol.140 , pp. 87-100
    • Rhodes, K.E.1    Raivich, G.2    Fawcett, J.W.3
  • 99
    • 7244226354 scopus 로고    scopus 로고
    • Increased expression of Nkx2.2 and Olig2 identifies reactive oligodendrocyte progenitor cells responding to demyelination in the adult CNS
    • Fancy, S.P.; Zhao, C.; Franklin, R.J. Increased expression of Nkx2.2 and Olig2 identifies reactive oligodendrocyte progenitor cells responding to demyelination in the adult CNS. Mol. Cell. Neurosci. 2004, 27, 247-254.
    • (2004) Mol. Cell. Neurosci , vol.27 , pp. 247-254
    • Fancy, S.P.1    Zhao, C.2    Franklin, R.J.3
  • 100
    • 0018774226 scopus 로고
    • Central remyelination restores secure conduction
    • Smith, K.J.; Blakemore, W.F.; McDonald, W.I. Central remyelination restores secure conduction. Nature 1979, 280, 395-396.
    • (1979) Nature , vol.280 , pp. 395-396
    • Smith, K.J.1    Blakemore, W.F.2    McDonald, W.I.3
  • 103
    • 0016348545 scopus 로고
    • Pattern of remyelination in the CNS
    • Blakemore, W.F. Pattern of remyelination in the CNS. Nature 1974, 249, 577-578.
    • (1974) Nature , vol.249 , pp. 577-578
    • Blakemore, W.F.1
  • 104
    • 0021267932 scopus 로고
    • Long-term remyelination fails to reconstitute normal thickness of central myelin sheaths
    • Ludwin, S.K.; Maitland, M. Long-term remyelination fails to reconstitute normal thickness of central myelin sheaths. J. Neurol. Sci. 1984, 64, 193-198.
    • (1984) J. Neurol. Sci , vol.64 , pp. 193-198
    • Ludwin, S.K.1    Maitland, M.2
  • 106
  • 107
    • 0033870097 scopus 로고    scopus 로고
    • Multiple sclerosis and chronic autoimmune encephalomyelitis: A comparative quantitative study of axonal injury in active, inactive, and remyelinated lesions
    • Kornek, B.; Storch, M.K.; Weissert, R.; Wallstroem, E.; Stefferl, A.; Olsson, T.; Linington, C.; Schmidbauer, M.; Lassmann, H. Multiple sclerosis and chronic autoimmune encephalomyelitis: A comparative quantitative study of axonal injury in active, inactive, and remyelinated lesions. Am. J. Pathol. 2000, 157, 267-276.
    • (2000) Am. J. Pathol , vol.157 , pp. 267-276
    • Kornek, B.1    Storch, M.K.2    Weissert, R.3    Wallstroem, E.4    Stefferl, A.5    Olsson, T.6    Linington, C.7    Schmidbauer, M.8    Lassmann, H.9
  • 108
    • 44949177395 scopus 로고    scopus 로고
    • Remyelination protects axons from demyelination-associated axon degeneration
    • Irvine, K.A.; Blakemore, W.F. Remyelination protects axons from demyelination-associated axon degeneration. Brain 2008, 131, 1464-1477.
    • (2008) Brain , vol.131 , pp. 1464-1477
    • Irvine, K.A.1    Blakemore, W.F.2
  • 109
    • 0036723599 scopus 로고    scopus 로고
    • Re-expression of PSA-NCAM by demyelinated axons: An inhibitor of remyelination in multiple sclerosis
    • Charles, P.; Reynolds, R.; Seilhean, D.; Rougon, G.; Aigrot, M.S.; Niezgoda, A.; Zalc, B.; Lubetzki, C. Re-expression of PSA-NCAM by demyelinated axons: An inhibitor of remyelination in multiple sclerosis? Brain 2002, 125, 1972-1979.
    • (2002) Brain , vol.125 , pp. 1972-1979
    • Charles, P.1    Reynolds, R.2    Seilhean, D.3    Rougon, G.4    Aigrot, M.S.5    Niezgoda, A.6    Zalc, B.7    Lubetzki, C.8
  • 111
    • 35348843539 scopus 로고    scopus 로고
    • Down-regulation of the axonal polysialic acid-neural cell adhesion molecule expression coincides with the onset of myelination in the human fetal forebrain
    • Jakovcevski, I.; Mo, Z.; Zecevic, N. Down-regulation of the axonal polysialic acid-neural cell adhesion molecule expression coincides with the onset of myelination in the human fetal forebrain. Neuroscience 2007, 149, 328-337.
    • (2007) Neuroscience , vol.149 , pp. 328-337
    • Jakovcevski, I.1    Mo, Z.2    Zecevic, N.3
  • 112
    • 34447543947 scopus 로고    scopus 로고
    • Down-regulation of polysialic acid is required for efficient myelin formation
    • Fewou, S.N.; Ramakrishnan, H.; Bussow, H.; Gieselmann, V.; Eckhardt, M. Down-regulation of polysialic acid is required for efficient myelin formation. J. Biol. Chem. 2007, 282, 16700-16711.
    • (2007) J. Biol. Chem , vol.282 , pp. 16700-16711
    • Fewou, S.N.1    Ramakrishnan, H.2    Bussow, H.3    Gieselmann, V.4    Eckhardt, M.5
  • 114
    • 0347917297 scopus 로고    scopus 로고
    • A role for the polysialic acid-neural cell adhesion molecule in PDGF-induced chemotaxis of oligodendrocyte precursor cells
    • Zhang, H.; Vutskits, L.; Calaora, V.; Durbec, P.; Kiss, J.Z. A role for the polysialic acid-neural cell adhesion molecule in PDGF-induced chemotaxis of oligodendrocyte precursor cells. J. Cell Sci. 2004, 117, 93-103.
    • (2004) J. Cell Sci , vol.117 , pp. 93-103
    • Zhang, H.1    Vutskits, L.2    Calaora, V.3    Durbec, P.4    Kiss, J.Z.5
  • 115
    • 77952242933 scopus 로고    scopus 로고
    • Signals to promote myelin formation and repair
    • Taveggia, C.; Feltri, M.L.; Wrabetz, L. Signals to promote myelin formation and repair. Nat. Rev. Neurol. 2010, 6, 276-287.
    • (2010) Nat. Rev. Neurol , vol.6 , pp. 276-287
    • Taveggia, C.1    Feltri, M.L.2    Wrabetz, L.3
  • 116
    • 73349100648 scopus 로고    scopus 로고
    • Notch: A new player in MS mechanisms
    • Jurynczyk, M.; Selmaj, K. Notch: A new player in MS mechanisms. J. Neuroimmunol. 2010, 218, 3-11.
    • (2010) J. Neuroimmunol , vol.218 , pp. 3-11
    • Jurynczyk, M.1    Selmaj, K.2
  • 117
    • 50849100996 scopus 로고    scopus 로고
    • The many facets of Notch ligands
    • D'Souza, B.; Miyamoto, A.; Weinmaster, G. The many facets of Notch ligands. Oncogene 2008, 27, 5148-5167.
    • (2008) Oncogene , vol.27 , pp. 5148-5167
    • D'Souza, B.1    Miyamoto, A.2    Weinmaster, G.3
  • 119
    • 4344625746 scopus 로고    scopus 로고
    • Notch1 and Jagged1 are expressed after CNS demyelination, but are not a major rate-determining factor during remyelination
    • Stidworthy, M.F.; Genoud, S.; Li, W.W.; Leone, D.P.; Mantei, N.; Suter, U.; Franklin, R.J. Notch1 and Jagged1 are expressed after CNS demyelination, but are not a major rate-determining factor during remyelination. Brain 2004, 127, 1928-1941.
    • (2004) Brain , vol.127 , pp. 1928-1941
    • Stidworthy, M.F.1    Genoud, S.2    Li, W.W.3    Leone, D.P.4    Mantei, N.5    Suter, U.6    Franklin, R.J.7
  • 121
    • 0036799650 scopus 로고    scopus 로고
    • Multiple sclerosis: Re-expression of a developmental pathway that restricts oligodendrocyte maturation
    • John, G.R.; Shankar, S.L.; Shafit-Zagardo, B.; Massimi, A.; Lee, S.C.; Raine, C.S.; Brosnan, C.F. Multiple sclerosis: Re-expression of a developmental pathway that restricts oligodendrocyte maturation. Nat. Med. 2002, 8, 1115-1121.
    • (2002) Nat. Med , vol.8 , pp. 1115-1121
    • John, G.R.1    Shankar, S.L.2    Shafit-Zagardo, B.3    Massimi, A.4    Lee, S.C.5    Raine, C.S.6    Brosnan, C.F.7
  • 122
    • 0142026496 scopus 로고    scopus 로고
    • Glial transforming growth factor (TGF)-beta isotypes in multiple sclerosis: Differential glial expression of TGF-β 1, 2 and 3 isotypes in multiple sclerosis
    • Peress, N.S.; Perillo, E.; Seidman, R.J. Glial transforming growth factor (TGF)-beta isotypes in multiple sclerosis: Differential glial expression of TGF-β 1, 2 and 3 isotypes in multiple sclerosis. J. Neuroimmunol. 1996, 71, 115-123.
    • (1996) J. Neuroimmunol , vol.71 , pp. 115-123
    • Peress, N.S.1    Perillo, E.2    Seidman, R.J.3
  • 124
    • 2942554826 scopus 로고    scopus 로고
    • NB-3/Notch1 pathway via Deltex1 promotes neural progenitor cell differentiation into oligodendrocytes
    • Cui, X.Y.; Hu, Q.D.; Tekaya, M.; Shimoda, Y.; Ang, B.T.; Nie, D.Y.; Sun, L.; Hu, W.P.; Karsak, M.; Duka, T.; et al. NB-3/Notch1 pathway via Deltex1 promotes neural progenitor cell differentiation into oligodendrocytes. J. Biol. Chem. 2004, 279, 25858-25865.
    • (2004) J. Biol. Chem , vol.279 , pp. 25858-25865
    • Cui, X.Y.1    Hu, Q.D.2    Tekaya, M.3    Shimoda, Y.4    Ang, B.T.5    Nie, D.Y.6    Sun, L.7    Hu, W.P.8    Karsak, M.9    Duka, T.10
  • 126
    • 33746308062 scopus 로고    scopus 로고
    • Glial inhibition of CNS axon regeneration
    • Yiu, G.; He, Z. Glial inhibition of CNS axon regeneration. Nat. Rev. Neurosci. 2006, 7, 617-627.
    • (2006) Nat. Rev. Neurosci , vol.7 , pp. 617-627
    • Yiu, G.1    He, Z.2
  • 127
    • 0037119581 scopus 로고    scopus 로고
    • Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor
    • Liu, B.P.; Fournier, A.; GrandPre, T.; Strittmatter, S.M. Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor. Science 2002, 297, 1190-1193.
    • (2002) Science , vol.297 , pp. 1190-1193
    • Liu, B.P.1    Fournier, A.2    Grandpre, T.3    Strittmatter, S.M.4
  • 128
    • 0037182860 scopus 로고    scopus 로고
    • Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth
    • Wang, K.C.; Koprivica, V.; Kim, J.A.; Sivasankaran, R.; Guo, Y.; Neve, R.L.; He, Z. Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth. Nature 2002, 417, 941-944.
    • (2002) Nature , vol.417 , pp. 941-944
    • Wang, K.C.1    Koprivica, V.2    Kim, J.A.3    Sivasankaran, R.4    Guo, Y.5    Neve, R.L.6    He, Z.7
  • 130
  • 132
    • 0035905799 scopus 로고    scopus 로고
    • Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration
    • Fournier, A.E.; GrandPre, T.; Strittmatter, S.M. Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration. Nature 2001, 409, 341-346.
    • (2001) Nature , vol.409 , pp. 341-346
    • Fournier, A.E.1    Grandpre, T.2    Strittmatter, S.M.3
  • 135
    • 44749091057 scopus 로고    scopus 로고
    • Troy/Taj and its role in CNS axon regeneration
    • Mi, S. Troy/Taj and its role in CNS axon regeneration. Cytokine Growth Factor Rev. 2008, 19, 245-251.
    • (2008) Cytokine Growth Factor Rev , vol.19 , pp. 245-251
    • Mi, S.1
  • 136
    • 67651177571 scopus 로고    scopus 로고
    • An integrin-contactin complex regulates CNS myelination by differential Fyn phosphorylation
    • Laursen, L.S.; Chan, C.W.; Ffrench-Constant, C. An integrin-contactin complex regulates CNS myelination by differential Fyn phosphorylation. J. Neurosci. 2009, 29, 9174-9185.
    • (2009) J. Neurosci , vol.29 , pp. 9174-9185
    • Laursen, L.S.1    Chan, C.W.2    Ffrench-Constant, C.3
  • 137
    • 0346849774 scopus 로고    scopus 로고
    • The p75 neurotrophin receptor: Multiple interactors and numerous functions
    • Gentry, J.J.; Barker, P.A.; Carter, B.D. The p75 neurotrophin receptor: Multiple interactors and numerous functions. Prog. Brain Res. 2004, 146, 25-39.
    • (2004) Prog. Brain Res , vol.146 , pp. 25-39
    • Gentry, J.J.1    Barker, P.A.2    Carter, B.D.3
  • 138
    • 2442463255 scopus 로고    scopus 로고
    • p75NTR is positively promiscuous: Novel partners and new insights
    • Barker, P.A. p75NTR is positively promiscuous: Novel partners and new insights. Neuron 2004, 42, 529-533.
    • (2004) Neuron , vol.42 , pp. 529-533
    • Barker, P.A.1
  • 140
    • 20444364506 scopus 로고    scopus 로고
    • Overcoming inhibitors in myelin to promote axonal regeneration
    • Domeniconi, M.; Filbin, M.T. Overcoming inhibitors in myelin to promote axonal regeneration. J. Neurol. Sci. 2005, 233, 43-47.
    • (2005) J. Neurol. Sci , vol.233 , pp. 43-47
    • Domeniconi, M.1    Filbin, M.T.2
  • 141
    • 33846148013 scopus 로고    scopus 로고
    • TROY and LINGO-1 expression in astrocytes and macrophages/microglia in multiple sclerosis lesions
    • Satoh, J.; Tabunoki, H.; Yamamura, T.; Arima, K.; Konno, H. TROY and LINGO-1 expression in astrocytes and macrophages/microglia in multiple sclerosis lesions. Neuropathol. Appl. Neurobiol. 2007, 33, 99-107.
    • (2007) Neuropathol. Appl. Neurobiol , vol.33 , pp. 99-107
    • Satoh, J.1    Tabunoki, H.2    Yamamura, T.3    Arima, K.4    Konno, H.5
  • 142
    • 34948888764 scopus 로고    scopus 로고
    • LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis
    • Mi, S.; Hu, B.; Hahm, K.; Luo, Y.; Kam Hui, E.S.; Yuan, Q.; Wong, W.M.; Wang, L.; Su, H.; Chu, T.H.; et al. LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis. Nat. Med. 2007, 13, 1228-1233.
    • (2007) Nat. Med , vol.13 , pp. 1228-1233
    • Mi, S.1    Hu, B.2    Hahm, K.3    Luo, Y.4    Kam Hui, E.S.5    Yuan, Q.6    Wong, W.M.7    Wang, L.8    Su, H.9    Chu, T.H.10
  • 143
    • 54349085579 scopus 로고    scopus 로고
    • LINGO-1 antagonists as therapy for multiple sclerosis: In vitro and in vivo evidence
    • Rudick, R.A.; Mi, S.; Sandrock, A.W., Jr. LINGO-1 antagonists as therapy for multiple sclerosis: In vitro and in vivo evidence. Expert Opin. Biol. Ther. 2008, 8, 1561-1570.
    • (2008) Expert Opin. Biol. Ther , vol.8 , pp. 1561-1570
    • Rudick, R.A.1    Mi, S.2    Sandrock Jr., A.W.3
  • 144
    • 0242266910 scopus 로고    scopus 로고
    • Integrin-linked kinase is required for laminin-2-induced oligodendrocyte cell spreading and CNS myelination
    • Chun, S.J.; Rasband, M.N.; Sidman, R.L.; Habib, A.A.; Vartanian, T. Integrin-linked kinase is required for laminin-2-induced oligodendrocyte cell spreading and CNS myelination. J. Cell Biol. 2003, 163, 397-408.
    • (2003) J. Cell Biol , vol.163 , pp. 397-408
    • Chun, S.J.1    Rasband, M.N.2    Sidman, R.L.3    Habib, A.A.4    Vartanian, T.5
  • 145
    • 0038933866 scopus 로고    scopus 로고
    • Compartmentation of Fyn kinase with glycosylphosphatidylinositol-anchored molecules in oligodendrocytes facilitates kinase activation during myelination
    • Kramer, E.M.; Klein, C.; Koch, T.; Boytinck, M.; Trotter, J. Compartmentation of Fyn kinase with glycosylphosphatidylinositol-anchored molecules in oligodendrocytes facilitates kinase activation during myelination. J. Biol. Chem. 1999, 274, 29042-29049.
    • (1999) J. Biol. Chem , vol.274 , pp. 29042-29049
    • Kramer, E.M.1    Klein, C.2    Koch, T.3    Boytinck, M.4    Trotter, J.5
  • 146
    • 70349326558 scopus 로고    scopus 로고
    • Laminin alters fyn regulatory mechanisms and promotes oligodendrocyte development
    • Relucio, J.; Tzvetanova, I.D.; Ao, W.; Lindquist, S.; Colognato, H. Laminin alters fyn regulatory mechanisms and promotes oligodendrocyte development. J. Neurosci. 2009, 29, 11794-11806.
    • (2009) J. Neurosci , vol.29 , pp. 11794-11806
    • Relucio, J.1    Tzvetanova, I.D.2    Ao, W.3    Lindquist, S.4    Colognato, H.5
  • 149
    • 0037122960 scopus 로고    scopus 로고
    • Premyelinating oligodendrocytes in chronic lesions of multiple sclerosis
    • Chang, A.; Tourtellotte, W.W.; Rudick, R.; Trapp, B.D. Premyelinating oligodendrocytes in chronic lesions of multiple sclerosis. N. Engl. J. Med. 2002, 346, 165-173.
    • (2002) N. Engl. J. Med , vol.346 , pp. 165-173
    • Chang, A.1    Tourtellotte, W.W.2    Rudick, R.3    Trapp, B.D.4
  • 150
    • 0031962240 scopus 로고    scopus 로고
    • Chronic stage multiple sclerosis lesions contain a relatively quiescent population of oligodendrocyte precursor cells
    • Wolswijk, G. Chronic stage multiple sclerosis lesions contain a relatively quiescent population of oligodendrocyte precursor cells. J. Neurosci. 1998, 18, 601-609.
    • (1998) J. Neurosci , vol.18 , pp. 601-609
    • Wolswijk, G.1
  • 151
    • 54249124952 scopus 로고    scopus 로고
    • Remyelination in the CNS: From biology to therapy
    • Franklin, R.J.; Ffrench-Constant, C. Remyelination in the CNS: From biology to therapy. Nat. Rev. Neurosci. 2008, 9, 839-855.
    • (2008) Nat. Rev. Neurosci , vol.9 , pp. 839-855
    • Franklin, R.J.1    Ffrench-Constant, C.2
  • 153
    • 46849098585 scopus 로고    scopus 로고
    • Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis
    • Kuhlmann, T.; Miron, V.; Cui, Q.; Wegner, C.; Antel, J.; Bruck, W. Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis. Brain 2008, 131, 1749-1758.
    • (2008) Brain , vol.131 , pp. 1749-1758
    • Kuhlmann, T.1    Miron, V.2    Cui, Q.3    Wegner, C.4    Antel, J.5    Bruck, W.6
  • 154
    • 33644910475 scopus 로고    scopus 로고
    • Differences in the early inflammatory responses to toxin-induced demyelination are associated with the age-related decline in CNS remyelination
    • Zhao, C.; Li, W.W.; Franklin, R.J. Differences in the early inflammatory responses to toxin-induced demyelination are associated with the age-related decline in CNS remyelination. Neurobiol. Aging 2006, 27, 1298-1307.
    • (2006) Neurobiol. Aging , vol.27 , pp. 1298-1307
    • Zhao, C.1    Li, W.W.2    Franklin, R.J.3
  • 155
    • 0037089096 scopus 로고    scopus 로고
    • Modelling large areas of demyelination in the rat reveals the potential and possible limitations of transplanted glial cells for remyelination in the CNS
    • Blakemore, W.F.; Chari, D.M.; Gilson, J.M.; Crang, A.J. Modelling large areas of demyelination in the rat reveals the potential and possible limitations of transplanted glial cells for remyelination in the CNS. Glia 2002, 38, 155-168.
    • (2002) Glia , vol.38 , pp. 155-168
    • Blakemore, W.F.1    Chari, D.M.2    Gilson, J.M.3    Crang, A.J.4
  • 156
    • 81755179436 scopus 로고    scopus 로고
    • Regulation of remyelination in multiple sclerosis
    • Hanafy, K.A.; Sloane, J.A. Regulation of remyelination in multiple sclerosis. FEBS Lett. 2011, 585, 3821-3828.
    • (2011) FEBS Lett , vol.585 , pp. 3821-3828
    • Hanafy, K.A.1    Sloane, J.A.2
  • 158
    • 35548986727 scopus 로고    scopus 로고
    • Dissecting demyelination
    • Miller, R.H.; Mi, S. Dissecting demyelination. Nat. Neurosci. 2007, 10, 1351-1354.
    • (2007) Nat. Neurosci , vol.10 , pp. 1351-1354
    • Miller, R.H.1    Mi, S.2
  • 159
    • 40349089504 scopus 로고    scopus 로고
    • The biology of CNS remyelination: The key to therapeutic advances
    • Franklin, R.J.; Kotter, M.R. The biology of CNS remyelination: The key to therapeutic advances. J. Neurol. 2008, 255, 19-25.
    • (2008) J. Neurol , vol.255 , pp. 19-25
    • Franklin, R.J.1    Kotter, M.R.2
  • 161
    • 14744298180 scopus 로고    scopus 로고
    • Engagement of human monocyte-derived dendritic cells into interleukin (IL)-12 producers by IL-1β + interferon (IFN)-gamma
    • Nakahara, T.; Urabe, K.; Fukagawa, S.; Uchi, H.; Inaba, K.; Furue, M.; Moroi, Y. Engagement of human monocyte-derived dendritic cells into interleukin (IL)-12 producers by IL-1β + interferon (IFN)-gamma. Clin. Exp. Immunol. 2005, 139, 476-482.
    • (2005) Clin. Exp. Immunol , vol.139 , pp. 476-482
    • Nakahara, T.1    Urabe, K.2    Fukagawa, S.3    Uchi, H.4    Inaba, K.5    Furue, M.6    Moroi, Y.7
  • 162
    • 81755184012 scopus 로고    scopus 로고
    • Cytokines and effector T cell subsets causing autoimmune CNS disease
    • Petermann, F.; Korn, T. Cytokines and effector T cell subsets causing autoimmune CNS disease. FEBS Lett. 2011, 585, 3747-3757.
    • (2011) FEBS Lett , vol.585 , pp. 3747-3757
    • Petermann, F.1    Korn, T.2
  • 163
    • 46949104323 scopus 로고    scopus 로고
    • IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition
    • Kroenke, M.A.; Carlson, T.J.; Andjelkovic, A.V.; Segal, B.M. IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition. J. Exp. Med. 2008, 205, 1535-1541.
    • (2008) J. Exp. Med , vol.205 , pp. 1535-1541
    • Kroenke, M.A.1    Carlson, T.J.2    Andjelkovic, A.V.3    Segal, B.M.4
  • 164
    • 77949973725 scopus 로고    scopus 로고
    • Astrocyte-restricted ablation of interleukin-17-induced Act1-mediated signaling ameliorates autoimmune encephalomyelitis
    • Kang, Z.; Altuntas, C.Z.; Gulen, M.F.; Liu, C.; Giltiay, N.; Qin, H.; Liu, L.; Qian, W.; Ransohoff, R.M.; Bergmann, C.; et al. Astrocyte-restricted ablation of interleukin-17-induced Act1-mediated signaling ameliorates autoimmune encephalomyelitis. Immunity 2010, 32, 414-425.
    • (2010) Immunity , vol.32 , pp. 414-425
    • Kang, Z.1    Altuntas, C.Z.2    Gulen, M.F.3    Liu, C.4    Giltiay, N.5    Qin, H.6    Liu, L.7    Qian, W.8    Ransohoff, R.M.9    Bergmann, C.10
  • 166
    • 57649244985 scopus 로고    scopus 로고
    • Neuroinflammation activates Mdr1b efflux transport through NFkappaB: Promoter analysis in BBB endothelia
    • Yu, C.; Argyropoulos, G.; Zhang, Y.; Kastin, A.J.; Hsuchou, H.; Pan, W. Neuroinflammation activates Mdr1b efflux transport through NFkappaB: Promoter analysis in BBB endothelia. Cell Physiol. Biochem. 2008, 22, 745-756.
    • (2008) Cell Physiol. Biochem , vol.22 , pp. 745-756
    • Yu, C.1    Argyropoulos, G.2    Zhang, Y.3    Kastin, A.J.4    Hsuchou, H.5    Pan, W.6
  • 167
    • 0036353262 scopus 로고    scopus 로고
    • Interleukin-1 regulates proliferation and differentiation of oligodendrocyte progenitor cells
    • Vela, J.M.; Molina-Holgado, E.; Arevalo-Martin, A.; Almazan, G.; Guaza, C. Interleukin-1 regulates proliferation and differentiation of oligodendrocyte progenitor cells. Mol. Cell. Neurosci. 2002, 20, 489-502.
    • (2002) Mol. Cell. Neurosci , vol.20 , pp. 489-502
    • Vela, J.M.1    Molina-Holgado, E.2    Arevalo-Martin, A.3    Almazan, G.4    Guaza, C.5
  • 168
    • 0041864076 scopus 로고    scopus 로고
    • Cytokine, chemokine and growth factor gene profiling of cultured human astrocytes after exposure to proinflammatory stimuli
    • Meeuwsen, S.; Persoon-Deen, C.; Bsibsi, M.; Ravid, R.; van Noort, J.M. Cytokine, chemokine and growth factor gene profiling of cultured human astrocytes after exposure to proinflammatory stimuli. Glia 2003, 43, 243-253.
    • (2003) Glia , vol.43 , pp. 243-253
    • Meeuwsen, S.1    Persoon-Deen, C.2    Bsibsi, M.3    Ravid, R.4    van Noort, J.M.5
  • 169
    • 34548133584 scopus 로고    scopus 로고
    • Multiple sclerosis: A complicated picture of autoimmunity
    • McFarland, H.F.; Martin, R. Multiple sclerosis: A complicated picture of autoimmunity. Nat. Immunol. 2007, 8, 913-919.
    • (2007) Nat. Immunol , vol.8 , pp. 913-919
    • McFarland, H.F.1    Martin, R.2
  • 170
    • 1342345214 scopus 로고    scopus 로고
    • The CD4-Th1 model for multiple sclerosis: A critical (correction of crucial) re-appraisal
    • Lassmann, H.; Ransohoff, R.M. The CD4-Th1 model for multiple sclerosis: A critical (correction of crucial) re-appraisal. Trends Immunol. 2004, 25, 132-137.
    • (2004) Trends Immunol , vol.25 , pp. 132-137
    • Lassmann, H.1    Ransohoff, R.M.2
  • 171
    • 0028956025 scopus 로고
    • Interferon gamma, interleukin 4 and transforming growth factor beta in experimental autoimmune encephalomyelitis in Lewis rats: Dynamics of cellular mRNA expression in the central nervous system and lymphoid cells
    • Issazadeh, S.; Mustafa, M.; Ljungdahl, A.; Hojeberg, B.; Dagerlind, A.; Elde, R.; Olsson, T. Interferon gamma, interleukin 4 and transforming growth factor beta in experimental autoimmune encephalomyelitis in Lewis rats: Dynamics of cellular mRNA expression in the central nervous system and lymphoid cells. J. Neurosci. Res. 1995, 40, 579-590.
    • (1995) J. Neurosci. Res , vol.40 , pp. 579-590
    • Issazadeh, S.1    Mustafa, M.2    Ljungdahl, A.3    Hojeberg, B.4    Dagerlind, A.5    Elde, R.6    Olsson, T.7
  • 176
    • 0344389016 scopus 로고    scopus 로고
    • Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis
    • Matusevicius, D.; Kivisakk, P.; He, B.; Kostulas, N.; Ozenci, V.; Fredrikson, S.; Link, H. Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis. Mult. Scler. 1999, 5, 101-104.
    • (1999) Mult. Scler , vol.5 , pp. 101-104
    • Matusevicius, D.1    Kivisakk, P.2    He, B.3    Kostulas, N.4    Ozenci, V.5    Fredrikson, S.6    Link, H.7
  • 177
    • 0742305831 scopus 로고    scopus 로고
    • Co-localization of sodium channel Nav1.6 and the sodium-calcium exchanger at sites of axonal injury in the spinal cord in EAE
    • Craner, M.J.; Hains, B.C.; Lo, A.C.; Black, J.A.; Waxman, S.G. Co-localization of sodium channel Nav1.6 and the sodium-calcium exchanger at sites of axonal injury in the spinal cord in EAE. Brain 2004, 127, 294-303.
    • (2004) Brain , vol.127 , pp. 294-303
    • Craner, M.J.1    Hains, B.C.2    Lo, A.C.3    Black, J.A.4    Waxman, S.G.5
  • 179
    • 34447319392 scopus 로고    scopus 로고
    • Calpain-calcineurin signaling in the pathogenesis of calcium-dependent disorder
    • Wu, H.Y.; Tomizawa, K.; Matsui, H. Calpain-calcineurin signaling in the pathogenesis of calcium-dependent disorder. Acta Med. Okayama 2007, 61, 123-137.
    • (2007) Acta Med. Okayama , vol.61 , pp. 123-137
    • Wu, H.Y.1    Tomizawa, K.2    Matsui, H.3
  • 180
    • 0026642163 scopus 로고
    • Calcium-activated neutral proteinase (calpain) activity in C6 cell line: Compartmentation of mu and m calpain
    • Banik, N.L.; Chakrabarti, A.K.; Konat, G.W.; Gantt-Wilford, G.; Hogan, E.L. Calcium-activated neutral proteinase (calpain) activity in C6 cell line: Compartmentation of mu and m calpain. J. Neurosci. Res. 1992, 31, 708-714.
    • (1992) J. Neurosci. Res , vol.31 , pp. 708-714
    • Banik, N.L.1    Chakrabarti, A.K.2    Konat, G.W.3    Gantt-Wilford, G.4    Hogan, E.L.5
  • 181
  • 182
    • 0025239566 scopus 로고
    • Regulation of the calcium-activated neutral proteinase (CANP) of bovine brain by myelin lipids
    • Chakrabarti, A.K.; Dasgupta, S.; Banik, N.L.; Hogan, E.L. Regulation of the calcium-activated neutral proteinase (CANP) of bovine brain by myelin lipids. Biochim. Biophys. Acta 1990, 1038, 195-198.
    • (1990) Biochim. Biophys. Acta , vol.1038 , pp. 195-198
    • Chakrabarti, A.K.1    Dasgupta, S.2    Banik, N.L.3    Hogan, E.L.4
  • 185
    • 77049099632 scopus 로고    scopus 로고
    • Targeting Cdk5 activity in neuronal degeneration and regeneration
    • Kanungo, J.; Zheng, Y.L.; Amin, N.D.; Pant, H.C. Targeting Cdk5 activity in neuronal degeneration and regeneration. Cell. Mol. Neurobiol. 2009, 29, 1073-1080.
    • (2009) Cell. Mol. Neurobiol , vol.29 , pp. 1073-1080
    • Kanungo, J.1    Zheng, Y.L.2    Amin, N.D.3    Pant, H.C.4
  • 186
    • 65849142691 scopus 로고    scopus 로고
    • Bax shuttling after rotenone treatment of neuronal primary cultures: Effects on cell death phenotypes
    • Gill, M.B.; Perez-Polo, J.R. Bax shuttling after rotenone treatment of neuronal primary cultures: Effects on cell death phenotypes. J. Neurosci. Res. 2009, 87, 2047-2065.
    • (2009) J. Neurosci. Res , vol.87 , pp. 2047-2065
    • Gill, M.B.1    Perez-Polo, J.R.2
  • 188
    • 0033784522 scopus 로고    scopus 로고
    • Acute multiple sclerosis characterized by extensive mononuclear phagocyte infiltration
    • Shields, D.C.; Avgeropoulos, N.G.; Banik, N.L.; Tyor, W.R. Acute multiple sclerosis characterized by extensive mononuclear phagocyte infiltration. Neurochem. Res. 2000, 25, 1517-1520.
    • (2000) Neurochem. Res , vol.25 , pp. 1517-1520
    • Shields, D.C.1    Avgeropoulos, N.G.2    Banik, N.L.3    Tyor, W.R.4
  • 189
    • 33750621156 scopus 로고    scopus 로고
    • A novel calpain inhibitor for the treatment of acute experimental autoimmune encephalomyelitis
    • Hassen, G.W.; Feliberti, J.; Kesner, L.; Stracher, A.; Mokhtarian, F. A novel calpain inhibitor for the treatment of acute experimental autoimmune encephalomyelitis. J. Neuroimmunol. 2006, 180, 135-146.
    • (2006) J. Neuroimmunol , vol.180 , pp. 135-146
    • Hassen, G.W.1    Feliberti, J.2    Kesner, L.3    Stracher, A.4    Mokhtarian, F.5
  • 190
    • 67651177581 scopus 로고    scopus 로고
    • Update on inflammation, neurodegeneration, and immunoregulation in multiple sclerosis: Therapeutic implications
    • Bennett, J.L.; Stuve, O. Update on inflammation, neurodegeneration, and immunoregulation in multiple sclerosis: Therapeutic implications. Clin. Neuropharmacol. 2009, 32, 121-132.
    • (2009) Clin. Neuropharmacol , vol.32 , pp. 121-132
    • Bennett, J.L.1    Stuve, O.2
  • 192
    • 79952247358 scopus 로고    scopus 로고
    • Regulation of Th1/Th17 cytokines and IDO gene expression by inhibition of calpain in PBMCs from MS patients
    • Smith, A.W.; Doonan, B.P.; Tyor, W.R.; Abou-Fayssal, N.; Haque, A.; Banik, N.L. Regulation of Th1/Th17 cytokines and IDO gene expression by inhibition of calpain in PBMCs from MS patients. J. Neuroimmunol. 2011, 232, 179-185.
    • (2011) J. Neuroimmunol , vol.232 , pp. 179-185
    • Smith, A.W.1    Doonan, B.P.2    Tyor, W.R.3    Abou-Fayssal, N.4    Haque, A.5    Banik, N.L.6
  • 193
    • 0033106023 scopus 로고    scopus 로고
    • Pathophysiological role of calpain in experimental demyelination
    • Shields, D.C.; Banik, N.L. Pathophysiological role of calpain in experimental demyelination. J. Neurosci. Res. 1999, 55, 533-541.
    • (1999) J. Neurosci. Res , vol.55 , pp. 533-541
    • Shields, D.C.1    Banik, N.L.2
  • 194
    • 53049091541 scopus 로고    scopus 로고
    • Prevention of axonal injury using calpain inhibitor in chronic progressive experimental autoimmune encephalomyelitis
    • Hassen, G.W.; Feliberti, J.; Kesner, L.; Stracher, A.; Mokhtarian, F. Prevention of axonal injury using calpain inhibitor in chronic progressive experimental autoimmune encephalomyelitis. Brain Res. 2008, 1236, 206-215.
    • (2008) Brain Res , vol.1236 , pp. 206-215
    • Hassen, G.W.1    Feliberti, J.2    Kesner, L.3    Stracher, A.4    Mokhtarian, F.5
  • 195
    • 57049142576 scopus 로고    scopus 로고
    • Time-dependent increases in protease activities for neuronal apoptosis in spinal cords of lewis rats during development of acute experimental autoimmune encephalomyelitis
    • Das, A.; Guyton, M.K.; Matzelle, D.D.; Ray, S.K.; Banik, N.L. Time-dependent increases in protease activities for neuronal apoptosis in spinal cords of lewis rats during development of acute experimental autoimmune encephalomyelitis. J. Neurosci. Res. 2008, 86, 2992-3001.
    • (2008) J. Neurosci. Res , vol.86 , pp. 2992-3001
    • Das, A.1    Guyton, M.K.2    Matzelle, D.D.3    Ray, S.K.4    Banik, N.L.5
  • 196
    • 77955355417 scopus 로고    scopus 로고
    • Calpeptin Attenuated Inflammation, Cell Death, and Axonal Damage in Animal Model of Multiple Sclerosis
    • Guyton, M.K.; Das, A.; Samantaray, S.; Wallace, G.C.; Butler, J.T.; Ray, S.K.; Banik, N.L. Calpeptin Attenuated Inflammation, Cell Death, and Axonal Damage in Animal Model of Multiple Sclerosis. J. Neurosci. Res. 2010, 88, 2398-2408.
    • (2010) J. Neurosci. Res , vol.88 , pp. 2398-2408
    • Guyton, M.K.1    Das, A.2    Samantaray, S.3    Wallace, G.C.4    Butler, J.T.5    Ray, S.K.6    Banik, N.L.7
  • 198
    • 5644273104 scopus 로고    scopus 로고
    • Antigen-based immunointervention in human autoimmune diseases
    • Adorini, L. Antigen-based immunointervention in human autoimmune diseases. Trends Biotechnol. 2004, 22, 547-549.
    • (2004) Trends Biotechnol , vol.22 , pp. 547-549
    • Adorini, L.1
  • 199
  • 200
    • 55649109630 scopus 로고    scopus 로고
    • T-cells expressing natural killer (NK) receptors are altered in multiple sclerosis and responses to alpha-galactosylceramide are impaired
    • O'Keeffe, J.; Gately, C.M.; Counihan, T.; Hennessy, M.; Leahy, T.; Moran, A.P.; Hogan, E.L. T-cells expressing natural killer (NK) receptors are altered in multiple sclerosis and responses to alpha-galactosylceramide are impaired. J. Neurol. Sci. 2008, 275, 22-28.
    • (2008) J. Neurol. Sci , vol.275 , pp. 22-28
    • O'Keeffe, J.1    Gately, C.M.2    Counihan, T.3    Hennessy, M.4    Leahy, T.5    Moran, A.P.6    Hogan, E.L.7
  • 202
    • 27944468567 scopus 로고    scopus 로고
    • Molecular mimicry, microbial infection, and autoimmune disease: Evolution of the concept
    • Oldstone, M.B. Molecular mimicry, microbial infection, and autoimmune disease: Evolution of the concept. Curr. Top. Microbiol. Immunol. 2005, 296, 1-17.
    • (2005) Curr. Top. Microbiol. Immunol , vol.296 , pp. 1-17
    • Oldstone, M.B.1
  • 204
    • 58849160520 scopus 로고    scopus 로고
    • Ceramide and neurodegeneration: Susceptibility of neurons and oligodendrocytes to cell damage and death
    • Jana, A.; Hogan, E.L.; Pahan, K. Ceramide and neurodegeneration: Susceptibility of neurons and oligodendrocytes to cell damage and death. J. Neurol. Sci. 2009, 278, 5-15.
    • (2009) J. Neurol. Sci , vol.278 , pp. 5-15
    • Jana, A.1    Hogan, E.L.2    Pahan, K.3
  • 205
    • 84862834591 scopus 로고    scopus 로고
    • Signaling and regulatory functions of bioactive sphingolipids as therapeutic targets in multiple sclerosis
    • Podbielska, M.; Krotkiewski, H.; Hogan, E.L. Signaling and regulatory functions of bioactive sphingolipids as therapeutic targets in multiple sclerosis. Neurochem. Res. 2012, 37, 1154-1169.
    • (2012) Neurochem. Res , vol.37 , pp. 1154-1169
    • Podbielska, M.1    Krotkiewski, H.2    Hogan, E.L.3
  • 206
    • 77949911081 scopus 로고    scopus 로고
    • The specialized iNKT cell system recognizes glycolipid antigens and bridges the innate and acquired immune systems with potential applications for cancer therapy
    • Taniguchi, M.; Tashiro, T.; Dashtsoodol, N.; Hongo, N.; Watarai, H. The specialized iNKT cell system recognizes glycolipid antigens and bridges the innate and acquired immune systems with potential applications for cancer therapy. Int. Immunol. 2010, 22, 1-6.
    • (2010) Int. Immunol , vol.22 , pp. 1-6
    • Taniguchi, M.1    Tashiro, T.2    Dashtsoodol, N.3    Hongo, N.4    Watarai, H.5
  • 207
    • 0027178514 scopus 로고
    • Analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8-α/β T cells demonstrates preferential use of several V β genes and an invariant TCR alpha chain
    • Porcelli, S.; Yockey, C.E.; Brenner, M.B.; Balk, S.P. Analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8-α/β T cells demonstrates preferential use of several V β genes and an invariant TCR alpha chain. J. Exp. Med. 1993, 178, 1-16.
    • (1993) J. Exp. Med , vol.178 , pp. 1-16
    • Porcelli, S.1    Yockey, C.E.2    Brenner, M.B.3    Balk, S.P.4
  • 208
    • 40949141800 scopus 로고    scopus 로고
    • The effect of glycosaminoglycans on rat gametes in vitro and the associated signal pathway
    • Borg, N.; Holland, M. The effect of glycosaminoglycans on rat gametes in vitro and the associated signal pathway. Reproduction 2008, 135, 311-319.
    • (2008) Reproduction , vol.135 , pp. 311-319
    • Borg, N.1    Holland, M.2
  • 210
    • 84962652786 scopus 로고    scopus 로고
    • Implications of lymphocyte anergy to glycolipids in multiple sclerosis (MS): INKT cells may mediate the MS infectious trigger
    • doi:110.4172/2155-9899.1000144
    • Hogan, E.L.; Podbielska, M.; O'Keeffe, J. Implications of lymphocyte anergy to glycolipids in multiple sclerosis (MS): iNKT cells may mediate the MS infectious trigger. J. Clin. Cell. Immunol. 2013, 4, 144, doi:110.4172/2155-9899.1000144.
    • (2013) J. Clin. Cell. Immunol , vol.4 , pp. 144
    • Hogan, E.L.1    Podbielska, M.2    O'Keeffe, J.3
  • 212
    • 79958251746 scopus 로고    scopus 로고
    • New ways to turn on NKT cells
    • Godfrey, D.I.; Rossjohn, J. New ways to turn on NKT cells. J. Exp. Med. 2011, 208, 1121-1125.
    • (2011) J. Exp. Med , vol.208 , pp. 1121-1125
    • Godfrey, D.I.1    Rossjohn, J.2
  • 214
    • 15044357461 scopus 로고    scopus 로고
    • Inflammation stimulates remyelination in areas of chronic demyelination
    • Foote, A.K.; Blakemore, W.F. Inflammation stimulates remyelination in areas of chronic demyelination. Brain 2005, 128, 528-539.
    • (2005) Brain , vol.128 , pp. 528-539
    • Foote, A.K.1    Blakemore, W.F.2
  • 215
    • 0035996192 scopus 로고    scopus 로고
    • New insights into remyelination failure in multiple sclerosis: Implications for glial cell transplantation
    • Chari, D.M.; Blakemore, W.F. New insights into remyelination failure in multiple sclerosis: Implications for glial cell transplantation. Mult. Scler. 2002, 8, 271-277.
    • (2002) Mult. Scler , vol.8 , pp. 271-277
    • Chari, D.M.1    Blakemore, W.F.2
  • 216
    • 54949108974 scopus 로고    scopus 로고
    • Prospects of cell therapy for disorders of myelin
    • Ben-Hur, T.; Goldman, S.A. Prospects of cell therapy for disorders of myelin. Ann. N. Y. Acad. Sci. 2008, 1142, 218-249.
    • (2008) Ann. N. Y. Acad. Sci , vol.1142 , pp. 218-249
    • Ben-Hur, T.1    Goldman, S.A.2
  • 218
    • 39549105606 scopus 로고    scopus 로고
    • Remyelination-promoting human IgMs: Developing a therapeutic reagent for demyelinating disease
    • Warrington, A.E.; Rodriguez, M. Remyelination-promoting human IgMs: Developing a therapeutic reagent for demyelinating disease. Curr. Top. Microbiol. Immunol. 2008, 318, 213-239.
    • (2008) Curr. Top. Microbiol. Immunol , vol.318 , pp. 213-239
    • Warrington, A.E.1    Rodriguez, M.2
  • 220
    • 0021647198 scopus 로고
    • Demyelination and remyelination in murine viral encephalomyelitis
    • Lang, W.; Rodriguez, M.; Lennon, V.A.; Lampert, P.W. Demyelination and remyelination in murine viral encephalomyelitis. Ann. N. Y. Acad. Sci. 1984, 436, 98-102.
    • (1984) Ann. N. Y. Acad. Sci , vol.436 , pp. 98-102
    • Lang, W.1    Rodriguez, M.2    Lennon, V.A.3    Lampert, P.W.4
  • 221
    • 0033231307 scopus 로고    scopus 로고
    • A therapeutic vaccine approach to stimulate axon regeneration in the adult mammalian spinal cord
    • Huang, D.W.; McKerracher, L.; Braun, P.E.; David, S. A therapeutic vaccine approach to stimulate axon regeneration in the adult mammalian spinal cord. Neuron 1999, 24, 639-647.
    • (1999) Neuron , vol.24 , pp. 639-647
    • Huang, D.W.1    McKerracher, L.2    Braun, P.E.3    David, S.4
  • 224
    • 0036509862 scopus 로고    scopus 로고
    • Human antibodies accelerate the rate of remyelination following lysolecithin-induced demyelination in mice
    • Bieber, A.J.; Warrington, A.; Asakura, K.; Ciric, B.; Kaveri, S.V.; Pease, L.R.; Rodriguez, M. Human antibodies accelerate the rate of remyelination following lysolecithin-induced demyelination in mice. Glia 2002, 37, 241-249.
    • (2002) Glia , vol.37 , pp. 241-249
    • Bieber, A.J.1    Warrington, A.2    Asakura, K.3    Ciric, B.4    Kaveri, S.V.5    Pease, L.R.6    Rodriguez, M.7
  • 225
    • 0032053402 scopus 로고    scopus 로고
    • Acceleration in the rate of CNS remyelination in lysolecithin-induced demyelination
    • Pavelko, K.D.; van Engelen, B.G.; Rodriguez, M. Acceleration in the rate of CNS remyelination in lysolecithin-induced demyelination. J. Neurosci. 1998, 18, 2498-2505.
    • (1998) J. Neurosci , vol.18 , pp. 2498-2505
    • Pavelko, K.D.1    van Engelen, B.G.2    Rodriguez, M.3
  • 226
    • 0030940002 scopus 로고    scopus 로고
    • Successful treatment of established relapsing experimental autoimmune encephalomyelitis in mice with a monoclonal natural autoantibody
    • Miller, D.J.; Bright, J.J.; Sriram, S.; Rodriguez, M. Successful treatment of established relapsing experimental autoimmune encephalomyelitis in mice with a monoclonal natural autoantibody. J. Neuroimmunol. 1997, 75, 204-209.
    • (1997) J. Neuroimmunol , vol.75 , pp. 204-209
    • Miller, D.J.1    Bright, J.J.2    Sriram, S.3    Rodriguez, M.4
  • 227
    • 0028071114 scopus 로고
    • Monoclonal autoantibodies promote central nervous system repair in an animal model of multiple sclerosis
    • Miller, D.J.; Sanborn, K.S.; Katzmann, J.A.; Rodriguez, M. Monoclonal autoantibodies promote central nervous system repair in an animal model of multiple sclerosis. J. Neurosci. 1994, 14, 6230-6238.
    • (1994) J. Neurosci , vol.14 , pp. 6230-6238
    • Miller, D.J.1    Sanborn, K.S.2    Katzmann, J.A.3    Rodriguez, M.4
  • 228
    • 0030024834 scopus 로고    scopus 로고
    • Monoclonal autoantibody SCH94.03, which promotes central nervous system remyelination, recognizes an antigen on the surface of oligodendrocytes
    • Asakura, K.; Miller, D.J.; Murray, K.; Bansal, R.; Pfeiffer, S.E.; Rodriguez, M. Monoclonal autoantibody SCH94.03, which promotes central nervous system remyelination, recognizes an antigen on the surface of oligodendrocytes. J. Neurosci. Res. 1996, 43, 273-281.
    • (1996) J. Neurosci. Res , vol.43 , pp. 273-281
    • Asakura, K.1    Miller, D.J.2    Murray, K.3    Bansal, R.4    Pfeiffer, S.E.5    Rodriguez, M.6
  • 229
    • 0036674424 scopus 로고    scopus 로고
    • Direct evidence that a human antibody derived from patient serum can promote myelin repair in a mouse model of chronic-progressive demyelinating disease
    • Mitsunaga, Y.; Ciric, B.; Van Keulen, V.; Warrington, A.E.; Paz Soldan, M.; Bieber, A.J.; Rodriguez, M.; Pease, L.R. Direct evidence that a human antibody derived from patient serum can promote myelin repair in a mouse model of chronic-progressive demyelinating disease. FASEB J. 2002, 16, 1325-1327.
    • (2002) FASEB J , vol.16 , pp. 1325-1327
    • Mitsunaga, Y.1    Ciric, B.2    van Keulen, V.3    Warrington, A.E.4    Paz Soldan, M.5    Bieber, A.J.6    Rodriguez, M.7    Pease, L.R.8
  • 230
    • 65249111527 scopus 로고    scopus 로고
    • Invited Article: Human natural autoantibodies in the treatment of neurologic disease
    • Rodriguez, M.; Warrington, A.E.; Pease, L.R. Invited Article: Human natural autoantibodies in the treatment of neurologic disease. Neurology 2009, 72, 1269-1276.
    • (2009) Neurology , vol.72 , pp. 1269-1276
    • Rodriguez, M.1    Warrington, A.E.2    Pease, L.R.3
  • 231
    • 0029922207 scopus 로고    scopus 로고
    • Glial cell transplantation and remyelination of the central nervous system
    • Duncan, I.D. Glial cell transplantation and remyelination of the central nervous system. Neuropathol. Appl. Neurobiol. 1996, 22, 87-100.
    • (1996) Neuropathol. Appl. Neurobiol , vol.22 , pp. 87-100
    • Duncan, I.D.1
  • 232
    • 1642578925 scopus 로고    scopus 로고
    • Antiapoptotic signaling by a remyelination-promoting human antimyelin antibody
    • Howe, C.L.; Bieber, A.J.; Warrington, A.E.; Pease, L.R.; Rodriguez, M. Antiapoptotic signaling by a remyelination-promoting human antimyelin antibody. Neurobiol. Dis. 2004, 15, 120-131.
    • (2004) Neurobiol. Dis , vol.15 , pp. 120-131
    • Howe, C.L.1    Bieber, A.J.2    Warrington, A.E.3    Pease, L.R.4    Rodriguez, M.5
  • 234
    • 9444237918 scopus 로고    scopus 로고
    • A human antibody that promotes remyelination enters the CNS and decreases lesion load as detected by T2-weighted spinal cord MRI in a virus-induced murine model of MS
    • Pirko, I.; Ciric, B.; Gamez, J.; Bieber, A.J.; Warrington, A.E.; Johnson, A.J.; Hanson, D.P.; Pease, L.R.; Macura, S.I.; Rodriguez, M. A human antibody that promotes remyelination enters the CNS and decreases lesion load as detected by T2-weighted spinal cord MRI in a virus-induced murine model of MS. FASEB J. 2004, 18, 1577-1579.
    • (2004) FASEB J , vol.18 , pp. 1577-1579
    • Pirko, I.1    Ciric, B.2    Gamez, J.3    Bieber, A.J.4    Warrington, A.E.5    Johnson, A.J.6    Hanson, D.P.7    Pease, L.R.8    Macura, S.I.9    Rodriguez, M.10
  • 238
  • 239
    • 0142040141 scopus 로고    scopus 로고
    • Pharmacodynamics, pharmacokinetics, and safety of multiple doses of FTY720 in stable renal transplant patients: A multicenter, randomized, placebo-controlled, phase I study
    • Kahan, B.D.; Karlix, J.L.; Ferguson, R.M.; Leichtman, A.B.; Mulgaonkar, S.; Gonwa, T.A.; Skerjanec, A.; Schmouder, R.L.; Chodoff, L. Pharmacodynamics, pharmacokinetics, and safety of multiple doses of FTY720 in stable renal transplant patients: A multicenter, randomized, placebo-controlled, phase I study. Transplantation 2003, 76, 1079-1084.
    • (2003) Transplantation , vol.76 , pp. 1079-1084
    • Kahan, B.D.1    Karlix, J.L.2    Ferguson, R.M.3    Leichtman, A.B.4    Mulgaonkar, S.5    Gonwa, T.A.6    Skerjanec, A.7    Schmouder, R.L.8    Chodoff, L.9
  • 241
    • 78449244305 scopus 로고    scopus 로고
    • Neurological S1P signaling as an emerging mechanism of action of oral FTY720 (fingolimod) in multiple sclerosis
    • Lee, C.W.; Choi, J.W.; Chun, J. Neurological S1P signaling as an emerging mechanism of action of oral FTY720 (fingolimod) in multiple sclerosis. Arch. Pharm. Res. 2010, 33, 1567-1574.
    • (2010) Arch. Pharm. Res , vol.33 , pp. 1567-1574
    • Lee, C.W.1    Choi, J.W.2    Chun, J.3
  • 242
    • 70849086174 scopus 로고    scopus 로고
    • FTY720 (fingolimod) in Multiple Sclerosis: Therapeutic effects in the immune and the central nervous system
    • Brinkmann, V. FTY720 (fingolimod) in Multiple Sclerosis: Therapeutic effects in the immune and the central nervous system. Br. J. Pharmacol. 2009, 158, 1173-1182.
    • (2009) Br. J. Pharmacol , vol.158 , pp. 1173-1182
    • Brinkmann, V.1
  • 243
    • 35348970884 scopus 로고    scopus 로고
    • Brain penetration of the oral immunomodulatory drug FTY720 and its phosphorylation in the central nervous system during experimental autoimmune encephalomyelitis: Consequences for mode of action in multiple sclerosis
    • Foster, C.A.; Howard, L.M.; Schweitzer, A.; Persohn, E.; Hiestand, P.C.; Balatoni, B.; Reuschel, R.; Beerli, C.; Schwartz, M.; Billich, A. Brain penetration of the oral immunomodulatory drug FTY720 and its phosphorylation in the central nervous system during experimental autoimmune encephalomyelitis: Consequences for mode of action in multiple sclerosis. J. Pharmacol. Exp. Ther. 2007, 323, 469-475.
    • (2007) J. Pharmacol. Exp. Ther , vol.323 , pp. 469-475
    • Foster, C.A.1    Howard, L.M.2    Schweitzer, A.3    Persohn, E.4    Hiestand, P.C.5    Balatoni, B.6    Reuschel, R.7    Beerli, C.8    Schwartz, M.9    Billich, A.10
  • 245
    • 3242683494 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice
    • Webb, M.; Tham, C.S.; Lin, F.F.; Lariosa-Willingham, K.; Yu, N.; Hale, J.; Mandala, S.; Chun, J.; Rao, T.S. Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice. J. Neuroimmunol. 2004, 153, 108-121.
    • (2004) J. Neuroimmunol , vol.153 , pp. 108-121
    • Webb, M.1    Tham, C.S.2    Lin, F.F.3    Lariosa-Willingham, K.4    Yu, N.5    Hale, J.6    Mandala, S.7    Chun, J.8    Rao, T.S.9
  • 246
    • 33645283403 scopus 로고    scopus 로고
    • FTY720, sphingosine 1-phosphate receptor modulator, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration
    • Kataoka, H.; Sugahara, K.; Shimano, K.; Teshima, K.; Koyama, M.; Fukunari, A.; Chiba, K. FTY720, sphingosine 1-phosphate receptor modulator, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration. Cell. Mol. Immunol. 2005, 2, 439-448.
    • (2005) Cell. Mol. Immunol , vol.2 , pp. 439-448
    • Kataoka, H.1    Sugahara, K.2    Shimano, K.3    Teshima, K.4    Koyama, M.5    Fukunari, A.6    Chiba, K.7
  • 248
    • 53149089045 scopus 로고    scopus 로고
    • Cyclical and dose-dependent responses of adult human mature oligodendrocytes to fingolimod
    • Miron, V.E.; Hall, J.A.; Kennedy, T.E.; Soliven, B.; Antel, J.P. Cyclical and dose-dependent responses of adult human mature oligodendrocytes to fingolimod. Am. J. Pathol. 2008, 173, 1143-1152.
    • (2008) Am. J. Pathol , vol.173 , pp. 1143-1152
    • Miron, V.E.1    Hall, J.A.2    Kennedy, T.E.3    Soliven, B.4    Antel, J.P.5
  • 249
    • 39049125218 scopus 로고    scopus 로고
    • FTY720 modulates human oligodendrocyte progenitor process extension and survival
    • Miron, V.E.; Jung, C.G.; Kim, H.J.; Kennedy, T.E.; Soliven, B.; Antel, J.P. FTY720 modulates human oligodendrocyte progenitor process extension and survival. Ann. Neurol. 2008, 63, 61-71.
    • (2008) Ann. Neurol , vol.63 , pp. 61-71
    • Miron, V.E.1    Jung, C.G.2    Kim, H.J.3    Kennedy, T.E.4    Soliven, B.5    Antel, J.P.6
  • 252
    • 84879239117 scopus 로고    scopus 로고
    • Daclizumab high-yield process in relapsing-remitting multiple sclerosis (SELECT): A randomised, double-blind, placebo-controlled trial
    • Gold, R.; Giovannoni, G.; Selmaj, K.; Havrdova, E.; Montalban, X.; Radue, E.W.; Stefoski, D.; Robinson, R.; Riester, K.; Rana, J.; et al. Daclizumab high-yield process in relapsing-remitting multiple sclerosis (SELECT): A randomised, double-blind, placebo-controlled trial. Lancet 2013, 381, 2167-2175.
    • (2013) Lancet , vol.381 , pp. 2167-2175
    • Gold, R.1    Giovannoni, G.2    Selmaj, K.3    Havrdova, E.4    Montalban, X.5    Radue, E.W.6    Stefoski, D.7    Robinson, R.8    Riester, K.9    Rana, J.10
  • 253
    • 84877890808 scopus 로고    scopus 로고
    • Monoclonal antibodies in neuroinflammatory diseases
    • Klotz, L.; Wiendl, H. Monoclonal antibodies in neuroinflammatory diseases. Expert Opin. Biol. Ther. 2013, 13, 831-846.
    • (2013) Expert Opin. Biol. Ther , vol.13 , pp. 831-846
    • Klotz, L.1    Wiendl, H.2
  • 254
    • 84878638136 scopus 로고    scopus 로고
    • Drugs in development for relapsing multiple sclerosis
    • Ali, R.; Nicholas, R.S.; Muraro, P.A. Drugs in development for relapsing multiple sclerosis. Drugs 2013, 73, 625-650.
    • (2013) Drugs , vol.73 , pp. 625-650
    • Ali, R.1    Nicholas, R.S.2    Muraro, P.A.3
  • 255
    • 84870202838 scopus 로고    scopus 로고
    • Current status of myelin replacement therapies in multiple sclerosis
    • Huang, J.K.; Franklin, R.J. Current status of myelin replacement therapies in multiple sclerosis. Prog. Brain Res. 2012, 201, 219-231.
    • (2012) Prog. Brain Res , vol.201 , pp. 219-231
    • Huang, J.K.1    Franklin, R.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.