LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex

Nature Neuroscience

Volumn 7, Issue 3, 2004, Pages 221-228

  Mi, Sha ^a   Lee, Xinhua ^a   Shao, Zhaohui ^a   Thill, Greg ^a   Ji, Benxiu ^a   Relton, Jane ^a   Levesque, Melissa ^a   Allaire, Norm ^a   Perrin, Steve ^a   Sands, Bryan ^a   Crowell, Thomas ^a   Cate, Richard L ^a   McCoy, John M ^a   Pepinsky, R Blake ^a  

^a BIOGEN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN PROTEIN; FC RECEPTOR; GLYCOPROTEIN; HYBRID PROTEIN; MEMBRANE PROTEIN; MYELIN; NOGO 66 RECEPTOR; PROTEIN LINGO 1; PROTEIN P75; RECEPTOR PROTEIN; RECEPTOR SUBUNIT; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; GENE ACTIVATION; GENE ACTIVITY; GENE CONSTRUCT; HUMAN; HUMAN TISSUE; LIGAND BINDING; NERVE CELL CULTURE; NERVE FIBER REGENERATION; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RAT; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; AXONS; BASE SEQUENCE; CELLS, CULTURED; DNA, COMPLEMENTARY; FETUS; HUMANS; MACROMOLECULAR SUBSTANCES; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; MUTATION; MYELIN PROTEINS; MYELIN SHEATH; MYELIN-ASSOCIATED GLYCOPROTEIN; NERVE REGENERATION; NERVE TISSUE PROTEINS; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTOR, NERVE GROWTH FACTOR; RECEPTORS, CELL SURFACE; RECEPTORS, NERVE GROWTH FACTOR; RECOMBINANT FUSION PROTEINS; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION;

EID: 10744222190     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn1188     Document Type: Article

References (38)

1. GrandPre, T., Nakamura, F., Vartanian, T. & Strittmatter, S.M. Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein. Nature 403, 439-444 (2000).
2. Chen, M.S. et al. Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1. Nature 403, 434-439 (2000).
3. Prinjha, R. et al. Inhibitor of neurite outgrowth in humans. Nature 403, 383-384 (2000).
4. Liu, B.P., Fournier, A., GrandPre, T. & Strittmatter, S.M. Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor. Science 297, 1190-1193 (2002).
5. Wang, K.C. et al. Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth. Nature 417, 941-944 (2002).
6. Domeniconi, M. et al. Myelin-associated glycoprotein interacts with the Nogo66 receptor to inhibit neurite outgrowth. Neuron 35, 283-290 (2002).
7. Caroni, P. & Schwab, M.E. Antibody against myelin-associated inhibitor of neurite growth neutralizes nonpermissive substrate properties of CNS white matter. Neuron 1, 85-96 (1988).
8. Fournier, A.E., GrandPre, T. & Strittmatter, S.M. Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration. Nature 409, 341-346 (2001).
9. Wang, K.C., Kim, J.A., Sivasankaran, R., Segal, R. & He, Z. P75 interacts with the Nogo receptor as a coreceptor for Nogo, MAG and OMgp. Nature 420, 74-78 (2002).
10. Song, H. & Poo, M. The cell biology of neuronal navigation. Nat. Cell Biol. 3, E81-88 (2001).
11. Yamashita, T. & Tohyama, M. The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI. Nat. Neurosci. 6, 461-467 (2003).
12. Hall, A. Rho GTPases and the actin cytoskeleton. Science 279, 509-514 (1998).
13. Yamashita, T., Higuchi, H. & Tohyama, M. The p75 receptor transduces the signal from myelin-associated glycoprotein to Rho. J. Cell Biol. 157, 565-570 (2002).
14. Mueller, B.K. Growth cone guidance: first steps towards a deeper understanding. Annu. Rev. Neurosci. 22, 351-388 (1999).
15. Liu, B.P. & Strittmatter, S.M. Semaphorin-mediated axonal guidance via Rho-related G proteins. Curr. Opin. Cell Biol. 13, 619-626 (2001).
16. Arcaro, A. The small GTP-binding protein Rac promotes the dissociation of gelsolin from actin filaments in neutrophils. J. Biol. Chem. 273, 805-813 (1998).
17. Dickson, B.J. Rho GTPases in growth cone guidance. Curr. Opin. Neurobiol. 11, 103-110 (2001).
18. Wahl, S., Barth, H., Ciossek, T., Aktories, K. & Mueller, B.K. Ephrin-A5 induces collapse of growth cones by activating Rho and Rho kinase. J. Cell Biol. 149, 263-270 (2000).
19. Wong, S.T. et al. A p75(NTR) and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein. Nat. Neurosci. 5, 1302-1308 (2002).
20. Aguayo, A.J., David, S. & Bray, G. M. Influences of the glial environment on the elongation of axons after injury: transplantation studies in adult rodents. J. Exp. Biol. 95, 231-240 (1981).
21. Chisholm, A. & Tessier-Lavigne, M. Conservation and divergence of axon guidance mechanisms. Curr. Opin. Neurobiol. 9, 603-615 (1999).
22. Fawcett, J.W. Astrocytic and neuronal factors affecting axon regeneration in the damaged central nervous system. Cell Tissue Res. 290, 371-377 (1997).
23. Schwab, M.E. & Caroni, P. Oligodendrocytes and CNS myelin are nonpermissive substrates for neurite growth and fibroblast spreading in vitro. J. Neurosci. 8, 2381-2393 (1988).
24. Hunt, D., Coffin, R.S. & Anderson, P.N. The Nogo receptor, its ligands and axonal regeneration in the spinal cord; a review. J. Neurocytol. 31, 93-120 (2002).
25. Ivanisevic, L., Banerjee, K. & Saragovi, H.U. Differential cross-regulation of TrkA and TrkC tyrosine kinase receptors with p75. Oncogene 22, 5677-5685 (2003).
26. Ricci, A. et al. Neurotrophin and neurotrophin receptor protein expression in the human lung. Am. J. Respir. Cell. Mol. Biol. 30, 12-19 (2003).
27. Robinson, L.L., Townsend, J. & Anderson, R.A. The human fetal testis is a site of expression of neurotrophins and their receptors: regulation of the germ cell and peritubular cell population. J. Clin. Endocrinol. Metab. 88, 3943-3951 (2003).
28. Chauhan, N.B. & Siegel, G.J. Effect of PPF and ALCAR on the induction of NGF- and p75-mRNA and on APP processing in Tg2576 brain. Neurochem. Int. 43, 225-233 (2003).
29. Barton, W.A. et al. Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins. Embo J. 22, 3291-3302 (2003).
30. Pignot, V. et al. Characterization of two novel proteins, NgRH1 and NgRH2, structurally and biochemically homologous to the Nogo-66 receptor. J. Neurochem. 85, 717-728 (2003).
31. Takahashi, N., Takahashi, Y. & Putnam, F.W. Periodicity of leucine and tandem repetition of a 24-amino acid segment in the primary structure of leucine-rich alpha 2-glycoprotein of human serum. Proc. Natl. Acad. Sci. USA 82, 1906-1910 (1985).
32. Nguyen-Ba-Charvet, K.T. & Chedotal, A. Role of Slit proteins in the vertebrate brain. J. Physiol. [Paris] 96, 91-98 (2002).
33. Kuja-Panula, J., Kiiltomaki, M., Yamashiro, T., Rouhiainen, A. & Rauvala, F. AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats. J. Cell Biol. 160, 963-973 (2003).
34. Ono, T., Sekino-Suzuki, N., Kikkawa, Y., Yonekawa, H. & Kawashima, S. Alivin 1, a novel neuronal activity-dependent gene, inhibits apoptosis and promotes survival of cerebellar granule neurons. J. Neurosci. 23, 5887-5896 (2003).
35. Lin, J.C., Ho, W.H., Gurney, A. & Rosenthal, A. The netrin-G1 ligand NGL-1 promotes the outgrowth of thalamocortical axons. Nat. Neurosci. 6, 1270-1276 (2003).
36. Ren, X.D., Kiosses, W.B. & Schwartz, M.A. Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton. Embo J. 18, 578-585 (1999).
37. Mi, S. et al. Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis. Nature 403, 785-789 (2000).
38. Flanagan, J.G. & Cheng, H.J. Alkaline phosphatase fusion proteins for molecular characterization and cloning of receptors and their ligands. Methods Enzymol. 327, 198-210 (2000).