Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1

Nature

Volumn 403, Issue 6768, 2000, Pages 434-439

  Chen, Malo S ^a   Huber, Andrea B ^a   Van Der Haar, Marjan E ^a   Frank, Marcus ^a   Schnell, Lisa ^a   Spillmann, Adrian A ^a   Christ, Franziska ^a   Schwab, Martin E ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; MONOCLONAL ANTIBODY IN1; MYELIN PROTEIN; NEURITE GROWTH INHIBITOR; PROTEIN NOGO A; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN INJURY; CELL STRAIN 3T3; CONTROLLED STUDY; MOLECULAR CLONING; NERVE CELL PLASTICITY; NERVE FIBER GROWTH; NERVE FIBER REGENERATION; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; RAT; SPINAL GANGLION;

3T3 CELLS; AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; BASE SEQUENCE; CATTLE; CELLS, CULTURED; CHO CELLS; CLONING, MOLECULAR; CRICETINAE; DNA, COMPLEMENTARY; GLYCOSYLATION; GROWTH INHIBITORS; HUMANS; MEMBRANE PROTEINS; MICE; MOLECULAR SEQUENCE DATA; MYELIN PROTEINS; NERVE REGENERATION; NEURITES; NEURONS; PROTEIN ISOFORMS; RATS; RECOMBINANT PROTEINS; TISSUE DISTRIBUTION;

ANIMALIA;

EID: 0034719513     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35000219     Document Type: Article

References (19)

1. Caroni, P. & Schwab, M. E. Antibody against myelin-associated inhibitor of neurite growth neutralize nonpermissive substrate properties of CNS white matter. Neuron 1, 85-96 (1988).
2. Schnell, L. & Schwab, M. E. Axonal regeneration in the rat spinal cord produced by an antibody against myelin-associated neurite growth inhibitors. Nature 343, 269-272 (1990).
3. Bregman, B. S. et al. Recovery from spinal cord injury mediated by antibodies to neurite growth inhibitors. Nature 378, 498-501 (1995).
4. Thallmair, M. et al. Neurite growth inhibitors restrict structural plasticity and functional recovery following corticospinal tract lesions. Nature Neurosci. 1, 124-131 (1998).
5. Spillmann, A. A., Bandtlow, C. E., Lottspeich, F., Keller, F. & Schwab, M. E. Identification and characterization of a bovine neurite growth inhibitor (bNI-220). J. Biol. Chem. 273, 19283-93 (1998).
6. Lee, N. H. et al. Comparative expressed-sequence-tag analysis of differential gene expression profiles in PC-12 cells before and after nerve growth factor treatment. Proc. Natl. Acad. Sci. USA 92, 8303-8307 (1995).
7. Welcher, A. A., Suter, U., De Leon, M., Snipes, G. J. & Shooter, E. M. A myelin protein is encoded by the homologue of a growth arrest-specific gene. Proc. Natl Acad. Sci. USA 88, 7195-7199 (1991).
8. Schaeren-Wierrers, N., Valenzuela, D. M., Frank, M. & Schwab, M. E. Characterization of a rat gene, rMAL, encoding a protein with four transmembrane domains in central and peripheral myelin. J. Neurosci. 15, 3755-3764 (1995).
9. Carohi, P. & Schwab, M. E. Two membrane protein fractions from rat central myelin with inhibitory properties for neurite growth and fibroblast spreading. J. Cell Biol. 106, 1281-1288 (1988).
10. Schwab, M. E. & Thoenen, H. Dissociated neurons regenerate into sciatic but not optic nerve explants in culture irrespective of neurotrophic factors. J. Neurosci, 5, 2415-2423 (1985).
11. Chen, M., Schnell, L., van der Haar, M., Oertle, T. & Schwab, M. Inhibitory activity and domain(s) of the myelin protein Nogo-A. Soc. Neurosci. Abstr. 25, 2030 (1999).
12. Roebroek, A. J. et al. Cloning and expression of alternative transcripts of a novel neuroendocrine-specific gene and identification of its 135-kDa translational product. J. Biol. Chem. 268, 13439-13447 (1993).
13. Wieczorek, D. F. & Hughes, S. R. Developmentally regulated cDNA expressed exclusively in neural tissue. Brain Res. Mol. Brain Res. 10, 33-41 (1991).
14. Ninkina, N. N., Baka, I. D. & Buchman, V. L. Rat and chicken s-rex/NSP mRNA: nucleotide sequence of main transcripts and expression of splice variants in rat tissues. Gene 184, 205-210 (1997).
15. Geister, J. G., Stubbs, L. J., Wasserman, W. W. & Mucenski, M. L. Molecular cloning of a novel mouse gene with predominant muscle and neural expression. Mamm. Genome 9, 274-282 (1998).
16. Roebroek, A. J. et al. Genomic organization of the human NSP gene, prototype of a novel gene family encoding reticulons. Genomics 32, 191-199 (1996).
17. Morris, N. J., Ross, S. A., Nevcu, J. M., Lane, W. S. & Lienhard, G. E. Cloning and preliminary characterization of a 121 kDa protein with multiple predicted C2 domains. Biochim. Biophys. Acta 1431, 523-530 (1999).
18. Nagose, T. et al. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA Res. 5, 169-176 (1998).
19. Rubin, B. P., Dusart, I. & Schwab, M. E. A monoclonal antibody (IN-1) which neutralizes neurite growth inhibitory proteins in the rat CNS recognizes antigens localized in CNS myelin. J. Neurocytol. 23, 209-217 (1996).