Successful treatment of established relapsing experimental autoimmune encephalomyelitis in mice with a monoclonal natural autoantibody

Journal of Neuroimmunology

Volumn 75, Issue 1-2, 1997, Pages 204-209

  Miller, David J ^a   Bright, John J ^b   Sriram, Subramaniam ^b   Rodriguez, Moses ^a  

^a MAYO CLINIC   (United States)

^b VANDERBILT UNIVERSITY   (United States)

Author keywords

central nervous system; demyelination; immunoglobulin; inflammation; multiple sclerosis

Indexed keywords

AUTOANTIBODY; MONOCLONAL ANTIBODY;

ADOPTIVE TRANSFER; ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEMALE; IMMUNOMODULATION; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIBODIES, MONOCLONAL; AUTOANTIBODIES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; IMMUNOGLOBULIN M; IMMUNOTHERAPY; MICE; MICE, INBRED STRAINS; RECURRENCE; SPINAL CORD; TREATMENT OUTCOME;

EID: 0030940002     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(97)00027-1     Document Type: Article

References (33)

1. Acha-Orbea, H., Mitchel, D.J., Timmermann, L., Wraith, D.C., Tausch, G.S., Waldor, M.K., Zamvil, S.S., McDevitt, H.O. and Steinman, L. (1988) Limited heterogeneity of T-cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention. Cell 54, 263-273.
2. Achiron, A., Margalit, R., Hershkoviz, R., Markovits, D., Reshef, T., Melamed, E., Cohen, I.R. and Lider, O. (1994) Intravenous immunoglobulin treatment of experimental T-cell-mediated autoimmune disease. Upregulation of T-cell proliferation and downregulation of tumor necrosis factor a secretion. J. Clin. Invest. 93, 600-605.
3. Achiron, A., Pras, E., Gilad, R., Ziv, I., Mandel, M., Gordon, C.R., Noy, S., Sarova-Pinhas, I. and Melamed, E. (1992) Open controlled therapeutic trial of intravenous immune globulin in relapsing-remitting multiple sclerosis. Arch. Neurol. 49, 1233-1247.
4. Andersson, A., Forsgren, S., Soderstrom, A. and Holmberg, D. (1991) Monoclonal, natural antibodies prevent development of diabetes in the non-obese diabetic (NOD) mouse. J. Autoimmun. 4, 733-742.
5. Asakura, K., Miller, D.J., Murray, K., Pfeiffer, S.E. and Rodriguez, M. (1996) Monoclonal autoantibody SCH94.03, which promotes CNS remyelination, recognizes an antigen on the surface of oligodendrocytes. J. Neurosci. Res. 43, 273-281.
6. Avrameas, S. and Ternynck, T. (1993) The natural autoantibody system: Between hypotheses and facts. Mol. Immunol. 30, 1133-1142.
7. Brod, S.A., Khan, M., Kerman, R.H. and Pappolla, M. (1995) Oral administration of human or murine interferon α suppresses relapses and modifies adoptive transfer in experimental autoimmune encephalomyelitis. J. Neuroimmunol. 58, 61-69.
8. Cohen, I.R. and Cooke, A. (1986) Natural autoantibodies might prevent autoimmune disease. Immunol. Today 7, 363-364.
9. Dietrich, G., Kaveri, S. and Kazatchkine, M.D. (1992) Modulation of autoimmunity by intravenous immune globulin through interaction with the function of the immune/idiotypic network. Clin. Immunol. Immunopathol. 62, S73-S81.
10. Johnson, K.P., Brooks, B.R., Cohen, J.A., Ford, C.C., Goldstein, J., Lisak, R.P., Myers, L.W., Panitch, H.S., Rose, J.W., Schiffer, R.B., Vollmer, T., Weiner, L.P., Wolinsky, J.S. and the Copolymer I Multiple Sclerosis Study Group (1995) Copolymer I reduces relapse rate and improves disability in relapsing-remitting multiple sclerosis: Results of a phase III multicenter, double-blind, placebo-controlled trial. Neurology 45, 1268-1276.
11. Lassmann, H., Brunner, C., Bradl, M. and Linington, C. (1988) Experimental allergic encephalomyelitis: The balance between encephalitogenic T-lymphocytes and demyelinating antibodies determines size and structure of demyelinated lesions. Acta Neuropathol. 75, 566-576.
12. Miller, D.J. and Rodriguez, M. (1995) A monoclonal autoantibody that promotes central nervous system remyelination in a model of multiple sclerosis is a natural autoantibody encoded by germline immunoglobulin genes. J. Immunol. 154, 2460-2469.
13. Miller, D.J., Asakura, K. and Rodriguez, M. (1995) Experimental strategies to promote central nervous remyelination in multiple sclerosis: Insights gained from the Theiler's virus model system. J. Neurol. Sci. 41, 291-296.
14. Miller, D.J., Njenga, M.K., Murray, P.D., Leibowitz, J. and Rodriguez, M. (1996a) A monoclonal natural autoantibody that promotes remyelination suppresses central nervous system inflammation and increases virus expression after Theiler's virus-induced demyelination. Int. Immunol. 8,:31-141.
15. Miller, D.J., Njenga, M.K., Parisi, J.E. and Rodriguez, M. (1996b) Multi-organ reactivity of a monoclonal natural autoantibody that promotes remyelination in a mouse model of multiple sclerosis. J. Histochem. Cytochem. 44, 1005-1011.
16. Miller, D.J., Sanborn, K.S., Katzmann, J.A. and Rodriguez, M. (1994) Monoclonal autoantibodies promote central nervous system repair in an animal model of multiple sclerosis. J. Neurosci. 14, 6230-6238.
17. Miller, S.D., Tan, L.J., Kennedy, M.K. and Dal Canto, M.C. (1991) Specific immunoregulation of the induction and effector stages of relapsing EAE via neuroantigen-specific tolerance induction. Ann. N.Y. Acad. Sci. 636, 79-94.
18. 1. J. Immunol. 146, 3012-3017.
19. 2. J. Neuroimmunol. 46, 175-184.
20. Rodriguez, M., Leibowitz, J. and David, C.S. (1986) Susceptibility to Theiler's virus-induced demyelination: Mapping of the gene within the H-2D region. J. Exp. Med. 163, 620-631.
21. Samson, M.F. and Smilek, D.E. (1995) Reversal of acute experimental autoimmune encephalomyelitis and prevention of relapses by treatment with a myelin basic protein peptide analogue modified to form long-lived peptide-MHC complexes. J. Immunol. 155, 2737-2746.
22. Schuller, E. and Govaerts, A. (1983) First results of immunotherapy with immunoglobulin G in multiple sclerosis patients. Eur. Neurol. 22, 205-212.
23. Selmaj, K., Papierz, W., Glabinski, A. and Kohno, T. (1995) Prevention of chronic relapsing experimental autoimmune encephalomyelitis by soluble tumor necrosis factor receptor I. J. Neuroimmunol. 56, 135-141.
24. Sriram, S., Carroll, L., Fortin, S., Cooper, S. and Ranges, G. (1988) In vivo modulation by monoclonal anti-CD4 antibody. II. Effect on T-cell response to myelin basic protein and experimental allergic encephalomyelitis. J. Immunol. 141, 464-468.
25. Sriram, S. and Roberts, C.A. (1986) Treatment of established chronic relapsing experimental allergic encephalomyelitis with anti-L3T4 antibodies. J. Immunol. 136, 4464-4469.
26. Sriram, S. and Steinman, L. (1983) Anti I-A antibody suppresses active encephalomyelitis: Treatment model for disease linked to IR genes. J. Exp. Med. 158, 1362-1367.
27. Steinman, L. (1991) The development of rational strategies for selective immunotherapy against autoimmune demyelinating diseases. Adv. Immunol. 49, 357-379.
28. Su, X. and Sriram, S. (1991) Treatment of chronic relapsing experimental allergic encephalomyelitis with the intravenous administration of splenocytes coupled to encephalitogenic peptide 91-103 of myelin basic protein. J. Neuroimmunol. 34, 181-190.
29. Sundblad, A., Hauser, S., Holmberg, D., Cazenave, P. and Coutinho, A. (1989) Suppression of antibody responses to the acetylcholine receptor by natural antibodies. Eur. J. Immunol. 19, 1425-1430.
30. Sundblad, A., Marcos, M.A.R., Malanchere, E., Castro, A., Haury, M., Huetz, F., Nobrega, A., Freitas, A. and Coutinho, A. (1994) Observations on the mode of action of normal immunoglobulin at high doses. Immunol. Rev. 139, 125-158.
31. The IFNB Multiple Sclerosis Study Group (1993) Interferon β-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial. Neurology 43, 655-661.
32. van Engelen, B.G.M., Hommes, O.R., Pinckers, A., Cruysberg, J.R.M., Barkhof, F. and Rodriguez, M. (1992) Improved vision after intravenous immunoglobulin in stable demyelinating optic neuritis. Ann. Neurol. 32, 834-835.
33. Whitham, R.H., Kotzin, B.L., Buenafe, A.C., Weinberg, A.D., Jones, R.E., Hashim, G.A., Hoy, C.M., Vandenbark, A.A. and Offner, H. (1993) Treatment of relapsing experimental autoimmune encephalomyelitis with T-cell receptor peptides. J. Neurosci. Res. 35, 115-128.