A therapeutic vaccine approach to stimulate axon regeneration in the adult mammalian spinal cord

Neuron

Volumn 24, Issue 3, 1999, Pages 639-647

  Huang, D W ^a   McKerracher, L ^b   Braun, P E ^c   David, S ^a  

^a MONTREAL GENERAL HOSPITAL   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

MYELIN; VACCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOSTIMULATION; MOTOR CONTROL; MOUSE; NERVE FIBER GROWTH; NERVE FIBER REGENERATION; NERVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL TRACT; SPINAL CORD;

EID: 0033231307     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-6273(00)81118-6     Document Type: Article

References (37)

1. Akinsegun, A., and Buxton, D.F. (1992). Differential sites of origin and collateralization of corticospinal neurons in the rat: a multiple fluorescent retrograde tracer study. Brain Res. 575, 86-92.
2. Bregman, B.S., Kunkel-Bagden, E., Schnell, L., Dai, H.N., Gao, D., and Schwab, M.E. (1995). Recovery from spinal cord injury mediated by antibodies to neurite growth inhibitors. Nature 378, 498-501.
3. Caroni, P., and Schwab, M.E. (1988). Antibody against myelin-associated inhibitor of neurite growth neutralizes nonpermissive substrate properties of CNS white matter. Neuron 1, 85-96.
4. David, S. (1998). Axon growth promoting and inhibitory molecules involved in regeneration in the adult mammalian central nervous system. Ment. Retard. Dev. Disabil. Res. Rev. 4, 171-178.
5. David, S., and Aguayo, A.J. (1981). Axonal regeneration into peripheral nervous system "bridges" after central nervous system injury in adult rats. Science 214, 931-933.
6. Davies, S.J.A., Fitch, M.T., Memberg, S.P., Hall, A.K., Raisman, G., and Silver, J. (1997). Regeneration of adult axons in white matter tracts of the central nervous system. Nature 390, 680-683.
7. Davies, S.J.A., Goucher, D.R., Doller, C., and Silver, J. (1999). Robust regeneration of adult sensory axons in degenerating white matter of the adult rat spinal cord. J. Neurosci. 19, 5810-5822.
8. Gaur, A., Wiers, B., Liu, A., Rothbard, J., and Fathman, C.G., (1992). Amelioration of autoimmune encephalomyelitis by myelin basic protein synthetic peptide-induced anergy. Science 258, 1491-1494.
9. Goverman, J., Brabb, T., Paez, A., Harrington, C., and van Dassow, P. (1997). Initiation and regulation of CNS autoimmunity. Crit. Rev. Immunol. 17, 469-480.
10. Hagg, T., Manthorpe, M., Vahlsing, H.L., and Varon, S. (1988). Delayed treatment with nerve growth factor reverses the apparent loss of cholinergic neurons after acute brain damage. Exp. Neurol. 101, 303-312.
11. Jensen, M.B., Finsen, B., and Zimmer, J. (1997). Morphological and immunophenotypic microglial changes in the denervated fascia dentata of adult rats: correlation with blood-brain barrier damage and astroglial reactions. Exp. Neurol. 143, 103-116.
12. Keirstead, H., Dyer, J.K., Sholomenko, G.N., McGraw, J., Delaney, K.R., and Steeves, J.D. (1995). Axonal regeneration and physiological activity following transection and immunological disruption of myelin within the hatchling chick spinal cord. J. Neurosci. 15, 6963-6974.
13. Kunkel-Bagden, E., Dai, H.-N., and Bregman, B.S. (1993). Methods to assess the development and recovery of locomotor function after spinal cord injury in rats. Exp. Neurol. 119, 153-164.
14. Li, M., and David, S. (1996). Topical glucocorticoids modulate the lesion interface after cerebral cortical stab wounds in adult rats. Glia 18, 306-318.
15. Li, M., Shibata, A., Li, C., Braun, P.E., McKerracher, L., Roder, J., Kater, S.B., and David, S. (1996). Myelin-associated glycoprotein inhibits neurite/axon growth and causes growth cone collapse. J. Neurosci. Res. 46, 404-414.
16. McKeon, R.J., Schreiber, R.C., and Silver, J. (1991). Reduction of neurite outgrowth in a model of glial scarring following CNS injury is correlated with the expression of inhibitory molecules on reactive astrocytes. J. Neurosci. 11, 3398-3411.
17. McKerracher, L., David, S., Jackson, D.L., Kottis, V., Dunn, R.J., and Braun, P.E. (1994). Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growth. Neuron 13, 805-811.
18. Mukhopadhyay, G., Doherty, P., Walsh, F.S. Crocker, P.R., and Filbin, M.T. (1994). A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration. Neuron 13, 757-767.
19. Neumann, F., and Woolf, C.J. (1999). Regeneration of dorsal column fibers into and beyond the lesion site following adult spinal cord injury. Neuron 23, 83-91.
20. Novikova, L., Novikova, J., and Kellerth, O. (1997). Persistent neuronal labeling by retrograde fluorescent tracers: a comparison between Fast Blue, Fluoro-Gold and various dextran conjugates. J. Neurosci. Methods 74, 9-15.
21. O'Neill, J.K., Baker, D., and Turk, J.L. (1992). Inhibition of chronic experimental allergic encephalomyelitis in the Biozzi AB/H mouse. J. Neuroimmunol. 41, 177-187.
22. Pindozolla, R.R., Doller, C., and Silver, J. (1993). Putative inhibitory extracellular matrix molecules at the dorsal root entry zone of the spinal cord during development and after root and sciatic nerve lesions. Dev. Biol. 156, 34-48.
23. Popovich, P.G., Horner, P.J., Mullin, B.B., and Stokes, B.T. (1996). A quantitative spinal analysis of the blood-spinal cord barrier. Exp. Neurol. 142, 258-275.
24. Rivero, V.E., Maccioni, M., Bucher, A.E., Roth, G.A., and Riera, C.M. (1997). Suppression of experimental autoimmune encephalomyelitis (EAE) by intraperitoneal administration of soluble myelin antigens in Wistar rats. J. Neuroimmunol. 72, 3-10.
25. Savio, T., and Schwab, M.E. (1990). Lesioned corticospinal tract axons regenerate in myelin-free rat spinal cord. Proc. Natl. Acad. Sci. USA 87, 4130-4133.
26. Schmued, L.C., and Fallon, J.H. (1986). Fluoro-gold: a new fluorescent retrograde axonal tracer with numerous unique properties. Brain Res. 377, 147-154.
27. Schnell, L., and Schwab, M.E. (1990). Axonal regeneration in the rat spinal cord produced by an antibody against myelin-associated neurite growth inhibitors. Nature 343, 269-272.
28. Schwab, M.E., and Schnell, L. (1991). Channeling of developing rat corticospinal tract axons by myelin-associated neurite growth inhibitors. J. Neurosci. 11, 709-721.
29. Schwab, M.E., Kapfhammer, J.P., and Bandtlow, C.E. (1993). Inhibitors of neurite growth. Annu. Rev. Neurosci. 16, 565-595.
30. Tang, S., Woodhall, R.W., Shen, Y.J., deBellard, M.E., Saffell, J.L., Doherty, P., Walsh, F.S., and Filbin, M.T. (1997). Soluble myelin-associated glycoprotein (MAG) found in vivo inhibits axonal regeneration. Mol. Cell. Neurosci. 9, 333-346.
31. Tavares, I., Lima, D., and Coimbra, A. (1996). The ventrolateral medulla of the rat is connected with the spinal cord dorsal horn by an indirect descending pathway relayed in the A5 noradrenergic cell group. J. Comp. Neurol. 374, 84-95.
32. Tetzlaff, W., Alexander, S.W., Miller, F.D., and Bisby, M. (1991). Response of facial and rubrospinal neurons to axotomy: changes in mRNA expression for cytoskeletal proteins and GAP-43. J. Neurosci. 11, 2528-2544.
33. Tonegawa, S.M.S. (1997). Tolerance induction and autoimmune encephalomyelitis amelioration after administration of myelin basic protein-derived peptide. J. Exp. Med. 186, 507-517.
34. Traugott, U., Raine, C.S., and McFarlin, D.E. (1985). Acute experimental allergic encephalomyelitis in the mouse: immunopathology of the developing lesion. Cell. Immunol. 91, 240-254.
35. Wang, X., Messing, A., and David, S. (1997). Axonal and nonneuronal cell responses to spinal cord injury in mice lacking glial fibrillary acidic protein. Exp. Neurol. 148, 568-576.
36. Weiner, H.L, Friedman, A., Miller, A., Khry, S.J., al-Sabbagh, A., Santos, L., Sayegh, M., Nussenblatt, R.B., Trentham, D.E., and Hafler, D.A. (1994). Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. Annu. Rev. Immunol. 12, 809-837.
37. Ye, J.H., and Houle, J.D. (1997). Treatment of the chronically injured spinal cord with neurotrophic factors can promote axonal regeneration from supraspinal neurons. Exp. Neurol. 143, 70-81.