A defect of sphingolipid metabolism modifies the properties of normal appearing white matter in multiple sclerosis

Brain

Volumn 131, Issue 11, 2008, Pages 3092-3102

  Wheeler, David ^a   Bandaru, Veera Venkata Ratnam ^a   Calabresi, Peter A ^a   Nath, Avindra ^a   Haughey, Norman J ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Multiple sclerosis; Myelin; Phospholipid; Sphingolipid

Indexed keywords

MYELIN; PHOSPHOLIPID; SPHINGOLIPID;

ADULT; ARTICLE; BRAIN TISSUE; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; GRAY MATTER; HUMAN; HUMAN TISSUE; LIPID BILAYER; LIPID COMPOSITION; LIPID METABOLISM; MALE; MULTIPLE SCLEROSIS; NERVE FIBER DEGENERATION; PRIORITY JOURNAL; WHITE MATTER;

ADULT; ALDEHYDES; BIOPHYSICS; BRAIN; CHOLESTEROL; FEMALE; HUMANS; LIPID PEROXIDATION; MALE; MEMBRANE LIPIDS; MIDDLE AGED; MODELS, BIOLOGICAL; MULTIPLE SCLEROSIS; MYELIN SHEATH; PHOSPHOLIPIDS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPHINGOLIPIDS; YOUNG ADULT;

EID: 55749104704     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awn190     Document Type: Article

References (43)

1. Balatoni B, Storch MK, Swoboda EM, Schonborn V, Koziel A, Lambrou GN, et al. FTY720 sustains and restores neuronal function in the DA rat model of MOG-induced experimental autoimmune encephalomyelitis. Brain Res Bull 2007; 74: 307-16.
2. Bandaru VV, McArthur JC, Sacktor N, Cutler RG, Knapp EL, Mattson MP, et al. Associative and predictive biomarkers of dementia in HIV-1-infected patients. Neurology 2007; 68: 1481-7.
3. Bartos A, Fialova L, Soukupova J, Kukal J, Malbohan I, Pitha J. Elevated intrathecal antibodies against the medium neurofilament subunit in multiple sclerosis. J Neurol 2007a; 254: 20-5.
4. Bartos A, Fialova L, Soukupova J, Kukal J, Malbohan I, Pitha J. Antibodies against light neurofilaments in multiple sclerosis patients. Acta Neurol Scand 2007b; 116: 100-7.
5. Bartosik-Psujek H, Stelmasiak Z. The CSF levels of total-tau and phosphotau in patients with relapsing-remitting multiple sclerosis. J Neural Transm 2006; 113: 339-45.
6. Baumruker T, Billich A, Brinkmann V. FTY720, an immunomodulatory sphingolipid mimetic: translation of a novel mechanism into clinical benefit in multiple sclerosis. Expert Opin Invest Drugs 2007; 16: 283-9.
7. Bloom M, Evans E, Mouritsen OG. Physical properties of the fluid lipid-bilayer component of cell membranes: a perspective. Q Rev Biophys 1991; 24: 293-397.
8. Bornstein MB, Raines CS. The initial structural lesion in serum-induced demyelination in vitro. Lab Invest 1976; 35: 391-401.
9. Brinkmann V, Davis MD, Heise CE, Albert R, Cottens S, Hof R, et al. The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J Biol Chem 2002; 277: 21453-7.
10. Chen JT, Collins DL, Freedman MS, Atkins HL, Arnold DL. Local magnetization transfer ratio signal inhomogeneity is related to subsequent change in MTR in lesions and normal-appearing white-matter of multiple sclerosis patients. Neuroimage 2005; 25: 1272-8.
11. Clarke CJ, Snook CF, Tani M, Matmati N, Marchesini N, Hannun YA. The extended family of neutral sphingomyelinases. Biochemistry 2006; 45: 11247-56.
12. Cudrici C, Ito T, Zafranskaia E, Niculescu F, Mullen KM, Vlaicu S, et al. Dendritic cells are abundant in non-lesional gray matter in multiple sclerosis. Exp Mol Pathol 2007; 83: 198-206.
13. De Stefano N, Narayanan S, Francis SJ, Smith S, Mortilla M, Tartaglia MC, et al. Diffuse axonal and tissue injury in patients with multiple sclerosis with low cerebral lesion load and no disability. Arch Neurol 2002; 59: 1565-71.
14. Derjaguin BV, Landau L. Theory of the stability of strongly charged hydrophobic sols and of the adhesion of strongly charged particles in solutions of electrolytes. Acta Physicochim URSS 1941; 14: 633-62.
15. Evans EA, Parsegian VA. Thermal-mechanical fluctuations enhance repulsion between bimolecular layers. Proc Natl Acad Sci USA 1986; 83: 7132-6.
16. Foster CA, Howard LM, Schweitzer A, Persohn E, Hiestand PC, Balatoni B, et al. Brain penetration of the oral immunomodulatory drug FTY720 and its phosphorylation in the central nervous system during experimental autoimmune encephalomyelitis: consequences for mode of action in multiple sclerosis. J Pharmacol Exp Ther 2007; 323: 469-75.
17. Fujino M, Funeshima N, Kitazawa Y, Kimura H, Amemiya H, Suzuki S, et al. Amelioration of experimental autoimmune encephalomyelitis in Lewis rats by FTY720 treatment. J Pharmacol Exp Ther 2003; 305: 70-7.
18. Genain CP, Cannella B, Hauser SL, Raine CS. Identification of autoantibodies associated with myelin damage in multiple sclerosis. Nat Med 1999; 5: 170-5.
19. Glabinski A, Tawsek NS, Bartosz G. Increased generation of superoxide radicals in the blood of MS patients. Acta Neurol Scand 1993; 88: 174-7.
20. Gustafsson MC, Dahlqvist O, Jaworski J, Lundberg P, Landtblom AM. Low choline concentrations in normal-appearing white matter of patients with multiple sclerosis and normal MR imaging brain scans. Am J Neuroradiol 2007; 28: 1306-12.
21. Hait NC, Oskeritzian CA, Paugh SW, Milstien S, Spiegel S. Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases. Biochim Biophys Acta 2006; 1758: 2016-26.
22. Haughey NJ, Cutler RG, Tamara A, McArthur JC, Vargas DL, Pardo CA, et al. Perturbation of sphingolipid metabolism and ceramide production in HIV-dementia. Ann Neurol 2004; 55: 257-67.
23. Hu Y, Doudevski I, Wood D, Moscarello M, Husted C, Genain C, et al. Synergistic interactions of lipids and myelin basic protein. Proc Natl Acad Sci USA 2004; 101: 13466-71.
24. Jung CG, Kim HJ, Miron VE, Cook S, Kennedy TE, Foster CA, et al. Functional consequences of S1P receptor modulation in rat oligodendroglial lineage cells. Glia 2007; 55: 1656-7.
25. Kappos L, Antel J, Comi G, Montalban X, O'Connor P, Polman CH, et al. Oral fingolimod (FTY720) for relapsing multiple sclerosis. N Engl J Med 2006; 355: 1124-40.
26. Kataoka H, Sugahara K, Shimano K, Teshima K, Koyama M, Fukunari A, et al. FTY720, sphingosine 1-phosphate receptor modulator, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration. Cell Mol Immunol 2005; 2: 439-48.
27. Marbois BN, Faull KF, Fluharty AL, Raval-Fernandes S, Rome LH. Analysis of sulfatide from rat cerebellum and multiple sclerosis white matter by negative ion electrospray mass spectrometry. Biochim Biophys Acta 2000; 1484: 59-70.
28. Moll NM, Rietsch AM, Ransohoff AJ, Cossoy MB, Huang D, Eichler FS, et al. Cortical demyelination in PML and MS: similarities and differences. Neurology 2008; 70: 336-43.
29. Moscatelli EA, Isaacson E. Gas liquid chromatographic analysis of sphingosine bases in sphingolipids of human normal and multiple sclerosis cerebral white matter. Lipids 1969; 4: 550-5.
30. Narayanan S, Francis SJ, Sled JG, Santos AC, Antel S, Levesque I, et al. Axonal injury in the cerebral normal-appearing white matter of patients with multiple sclerosis is related to concurrent demyelination in lesions but not to concurrent demyelination in normal-appearing white matter. Neuroimage 2006; 29: 637-42.
31. Ohler B, Graf K, Bragg R, Lemons T, Coe R, Genain C, et al. Role of lipid interactions in autoimmune demyelination. Biochim Biophys Acta 2004; 1688: 10-7.
32. Osinde M, Mullershausen F, Dev KK. Phosphorylated FTY720 stimulates ERK phosphorylation in astrocytes via S1P receptors. Neuropharmacology 2007; 52: 1210-8.
33. Reich DS, Zackowski KM, Gordon-Lipkin EM, Smith SA, Chodkowski BA, Cutter GR, et al. Corticospinal tract abnormalities are associated with weakness in multiple sclerosis. Am J Neuroradiol 2007; 29: 333-339.
34. Sedzik J, Blaurock AE. Myelin vesicles: what we know and what we do not know. J Neurosci Res 1995; 41: 145-52.
35. Semra YK, Seidi OA, Sharief MK. Heightened intrathecal release of axonal cytoskeletal proteins in multiple sclerosis is associated with progressive disease and clinical disability. J Neuroimmunol 2002; 122: 132-9.
36. Servuss RM, Harbich W, Helfrich W. Measurement of the curvature-elastic modulus of egg lecithin bilayers. Biochim Biophys Acta 1976; 436: 900-3.
37. Skundric DS, Cai J, Cruikshank WW, Gveric D. Production of IL-16 correlates with CD4+ Th1 inflammation and phosphorylation of axonal cytoskeleton in multiple sclerosis lesions. J Neuroinflammation 2006; 3: 13.
38. Tartaglia MC, Narayanan S, De Stefano N, Arnaoutelis R, Antel SB, Francis SJ, et al. Choline is increased in pre-lesional normal appearing white matter in multiple sclerosis. J Neurol 2002; 249: 1382-90.
39. Verwey EJW, Overbeek JTG. Theory of the stability of lyophobic colloids. The interaction of particles having an electric double layer New York, Amsterdam: Elsevier; 1948.
40. Wattjes MP, Harzheim M, Lutterbey GG, Bogdanow M, Schild HH, Traber F. High field MR imaging and (1)H-MR spectroscopy in clinically isolated syndromes suggestive of multiple sclerosis: correlation between metabolic alterations and diagnostic MR imaging criteria. J Neurol 2008; 255: 56-63.
41. Wattjes MP, Harzheim M, Lutterbey GG, Klotz L, Schild HH, Traber F. Axonal damage but no increased glial cell activity in the normal-appearing white matter of patients with clinically isolated syndromes suggestive of multiple sclerosis using high-field magnetic resonance spectroscopy. Am J Neuroradiol 2007; 28: 1517-22.
42. Webb M, Tham CS, Lin FF, Lariosa-Willingham K, Yu N, Hale J, et al. Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice. J Neuroimmunol 2004; 153: 108-21.
43. Yu CS, Zhu CZ, Li KC, Xuan Y, Qin W, Sun H, et al. Relapsing neuromyelitis optica and relapsing-remitting multiple sclerosis: differentiation at diffusion-tensor MR imaging of corpus callosum. Radiology 2007; 244: 249-56.