Removal of phospho-head groups of membrane lipids immobilizes voltage sensors of K+ channels

Nature

Volumn 451, Issue 7180, 2008, Pages 826-829

  Xu, Yanping ^a   Ramu, Yajamana ^a   Lu, Zhe ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE 1 PHOSPHATE; HEMOLYSIN; MEMBRANE LIPID; METHYL BETA CYCLODEXTRIN; SHAKER POTASSIUM CHANNEL; SPHINGOMYELIN; SPHINGOMYELIN PHOSPHODIESTERASE; VOLTAGE GATED POTASSIUM CHANNEL;

CATION; ENZYME; IMMOBILIZATION; LIPID; POTASSIUM; REMOVAL EXPERIMENT;

ARTICLE; BACILLUS ANTHRACIS; CHANNEL GATING; CHIMERA; CORYNEBACTERIUM PSEUDOTUBERCULOSIS; ELECTRIC POTENTIAL; LIPID BILAYER; LIPID HYDROLYSIS; MUTANT; NONHUMAN; OOCYTE; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; WILD TYPE; XENOPUS;

EID: 39149109885     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature06618     Document Type: Article

References (31)

1. + channel. Neuron 16, 1169-1177 (1996).
2. + channel. Neuron 16, 1159-1167 (1996).
3. Armstrong, C. M. Sodium channels and gating currents. Physiol. Rev. 61, 644-683 (1981).
4. + channel. Neuron 14, 1293-1301 (1995).
5. Long, S. B., Campbell, E. B. & MacKinnon, R. Voltage sensor of Kv1.2: structural basis of electromechanical coupling. Science 309, 903-908 (2005).
6. + channel in a lipid bilayer. Science 306, 491-495 (2004).
7. Freites, J. A., Tobias, D. J., von Heijne, G. & White, S. H. Interface connections of a transmembrane voltage sensor. Proc. Natl Acad. Sci. USA 102, 15059-15064 (2005).
8. Ramu, Y., Xu, Y. & Lu, Z. Enzymatic activation of voltage-gated potassium channels. Nature 442, 696-699 (2006).
9. Schmidt, D., Jiang, Q. X. & MacKinnon, R. Phospholipids and the origin of cationic gating charges in voltage sensors. Nature 444, 775-779 (2006).
10. Glenny, A. T. & Stevens, N. F. Staphylococcal toxins and antitoxins. J. Pathol. Bacteriol. 40, 201-210 (1935).
11. McNamara, P. J., Cuevas, W. A. & Songer, J. G. Toxic phospholipases D of Corynebacterium pseudotuberculosis, C. ulcerans and Arcanobacterium haemolyticum: cloning and sequence homology. Gene 156, 113-118 (1995).
12. Kurpiewski, G., Forrester, L. J., Barrett, J. T. & Campbell, B. J. Platelet aggregation and sphingomyelinase D activity of a purified toxin from the venom of Loxosceles reclusa. Biochim. Biophys. Acta 678, 467-476 (1981).
13. Doery, H. M., Magnusson, B. J., Cheyne, I. M. & Sulasekharam, J. A phospholipase in staphylococcal toxin which hydrolyses sphingomyelin. Nature 198, 1091-1092 (1963).
14. Read, T. D. et al. The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria. Nature 423, 81-86 (2003).
15. Projan, S. J. et al. Nucleotide sequence: the β-hemolysin gene of Staphylococcus aureus. Nucleic Acids Res. 17, 3305 (1989).
16. Kilsdonk, E. P. et al. Cellular cholesterol efflux mediated by cyclodextrins. J. Biol. Chem. 270, 17250-17256 (1995).
17. Lu, Z., Klem, A. M. & Ramu, Y. Ion conduction pore is conserved among potassium channels. Nature 413, 809-813 (2001).
18. + channels. Neuron 18, 675-682 (1997).
19. Phillips, L. R. et al. Voltage-sensor activation with a tarantula toxin as cargo. Nature 436, 857-860 (2005).
20. + channel through multiple binding sites. Neuron 18, 665-673 (1997).
21. Armstrong, C. M. & Bezanilla, F. Currents related to movement of the gating particles of the sodium channels. Nature 242, 459-461 (1973).
22. Hoshi, T., Zagotta, W. N. & Aldrich, R. W. Biophysical and molecular mechanisms of Shaker potassium channel inactivation. Science 250, 533-538 (1990).
23. Kitaguchi, T., Sukhareva, M. & Swartz, K. J. Stabilizing the closed S6 gate in the Shaker Kv channel through modification of a hydrophobic seal. J. Gen. Physiol. 124, 319-332 (2004).
24. Schoppa, N. E., McCormack, K., Tanouye, M. A. & Sigworth, F. J. The size of gating charge in wild-type and mutant Shaker potassium channels. Science 255, 1712-1715 (1992).
25. Loboda, A. & Armstrong, C. M. Resolving the gating charge movement associated with late transitions in K channel activation. Biophys. J. 81, 905-916 (2001).
26. + channels in human T lymphocytes: a role in mitogenesis? Nature 307, 465-468 (1984).
27. + channels in T lymphocytes: a patch clamp study using monoclonal antibody adhesion. Nature 307, 468-471 (1984).
28. + channels as targets for specific immunomodulation. Trends Pharmacol. Sci. 25, 280-289 (2004).
29. + channels. Neuron 11, 353-358 (1993).
30. Ramu, Y., Xu, Y. & Lu, Z. Inhibition of CFTR Cl-channel function caused by enzymatic hydrolysis of sphingomyelin. Proc. Natl Acad. Sci. USA 104, 6448-6453 (2007).
31. Swartz, K. J. & MacKinnon, R. An inhibitor of the Kv2.1 potassium channel isolated from the venom of a Chilean tarantula. Neuron 15, 941-949 (1995).