Modelling large areas of demyelination in the rat reveals the potential and possible limitations of transplanted glial cells for remyelination in the CNS

GLIA

Volumn 38, Issue 2, 2002, Pages 155-168

  Blakemore, W F ^a   Chari, D M ^a   Gilson, J M ^a   Crang, A J ^a  

^a Department of Clinical Veterinary Medicine ^*  (United Kingdom)

Author keywords

Multiple sclerosis; Oligodendrocyte progenitors; Remyelination; Schwann cells; Transplantation

Indexed keywords

ANIMALS; ANIMALS, NEWBORN; BRAIN TISSUE TRANSPLANTATION; CELL MOVEMENT; DEMYELINATING DISEASES; ENZYME INHIBITORS; ETHIDIUM; LYSOPHOSPHATIDYLCHOLINES; MULTIPLE SCLEROSIS; NERVE FIBERS, MYELINATED; NERVE REGENERATION; OLIGODENDROGLIA; RATS; RATS, INBRED STRAINS; STEM CELL TRANSPLANTATION; STEM CELLS;

EID: 0037089096     PISSN: 08941491     EISSN: None     Source Type: Journal    
DOI: 10.1002/glia.10067     Document Type: Article

References (27)

1. Transplantation of clonal neural precursor cells derived from adult human brain establishes functional peripheral myelin in the rat spinal cord
2. Extensive oligodendrocyte remyelination following injection of cultured central nervous system cells into demyelinating lesions in adult central nervous system
3. Transplantation of glial cells into areas of demyelination in the adult rat spinal cord
4. Transplantation options for therapeutic CNS remyelination
5. Delayed infarction of spinal cord white matter following x-irradiation
6. Suppression of remyelination in the CNS by x-irradiation
7. Transplanted glial cells migrate over a greater distance and remyelinate demyelinated lesions more rapidly than endogenous remyelinating cells
8. Embryonic stem cell-derived glial precursors: A source of myelinating transplants
9. Efficient recolonisation of progenitor-depleted areas of the CNS by adult oligodendrocyte progenitor cells
10. The effect of the number of oligodendrocytes transplanted into x-irradiated, glial-free lesions on the extent of oligodendrocyte remyelination
11. Transplantation of normal and genetically-engineered glia into areas of demyelination
12. Type-1 astrocytes fail to inhibit Schwann cell remyelination of CNS axons in the absence of cells of the O-2A lineage
13. Transplanted CG4 cells (an oligodendrocyte progenitor cell line) survive, migrate and contribute to repair of areas of demyelination in X-irradiated and damaged spinal cord, but not in normal spinal cord
14. Local recruitment of remyelinating cells in the repair of demyelination in the central nervous system
15. Astrocyte and macrophage interactions in promoting oligodendrocyte remyelination in the CNS
16. Distinctive patterns of PDGF-A, FGF-2, IGF-1, and TGF-beta1 gene expression during remyelination of experimentally-induced spinal cord demyelination
17. Depletion of endogenous oligodendrocyte progenitors rather than increased availability of survival factors is a likely explanation for the enhanced survival of transplanted oligodendrocyte progenitors in X-irradiated compared to normal CNS
18. Areas of demyelination do not attract significant numbers of Schwann cells transplanted into normal white matter
19. Schwann cells transplanted into normal and x-irradiated adult white matter do not migrate extensively and show poor long-term survival
20. PSA-NCAM positive CNS precursors generate both oligodendrocytes and Schwann cells to remyelinate the CNS following transplantation
21. A common neural progenitor for the CNS and PNS
22. Co-localization of NG2 proteoglycan and PDGF α-receptor on O2A progenitor cells in the developing rat brain
23. Reconstruction of the glial environment of a photochemically-induced lesion in the rat spinal cord by transplantation of mixed glial cells
24. The effect of injection technique on the passive spread of astrocytes following transplantation into the rat spinal cord
25. Transplantation of glial cells enhances action potential conduction of amyelinated spinal cord axons in the myelin-deficient rat
26. Cooperation between PDGF and FGF converts slowly dividing O-2A(adult) progenitor cells to rapidly dividing cells with characteristics of O-2A(perinatal) progenitor cells
27. Remyelination and restoration of axonal function by glial cell transplantation