메뉴 건너뛰기




Volumn 29, Issue 8, 2009, Pages 1073-1080

Targeting Cdk5 activity in neuronal degeneration and regeneration

Author keywords

Cdk5; Hyperphosphorylation; Neurodegeneration; Neuron regeneration; Tau

Indexed keywords

CALCIUM; CALPAIN; CYCLIN DEPENDENT KINASE 5; CYCLIN DEPENDENT KINASE INHIBITOR; CYTOSKELETON PROTEIN; PROTEIN P35; ENZYME ACTIVATOR; PEPTIDE;

EID: 77049099632     PISSN: 02724340     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10571-009-9410-6     Document Type: Review
Times cited : (50)

References (86)
  • 2
    • 0032859938 scopus 로고    scopus 로고
    • Inhibition of tau phosphorylating protein kinase cdk5 prevents β-amyloid-induced neuronal death
    • DOI 10.1016/S0014-5793(99)01279-X, PII S001457939901279X
    • A Alvarez R Toro A Caceres RB Maccioni 1999 Inhibition of tau phosphorylating protein kinase cdk5 prevents beta-amyloid-induced neuronal death FEBS Lett 459 421 426 10.1016/S0014-5793(99)01279-X 10.1016/S0014-5793(99) 01279-X 10526177 1:CAS:528:DyaK1MXmvVKjsLc%3D (Pubitemid 29467380)
    • (1999) FEBS Letters , vol.459 , Issue.3 , pp. 421-426
    • Alvarez, A.1    Toro, R.2    Caceres, A.3    Maccioni, R.B.4
  • 3
    • 20044367108 scopus 로고    scopus 로고
    • Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms
    • DOI 10.1523/JNEUROSCI.4637-04.2005
    • C Andorfer CM Acker Y Kress PR Hof K Duff P Davies 2005 Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms J Neurosci 25 5446 5454 10.1523/JNEUROSCI.4637-04.2005 10.1523/JNEUROSCI.4637-04.2005 15930395 1:CAS:528:DC%2BD2MXlt1ynsro%3D (Pubitemid 40770926)
    • (2005) Journal of Neuroscience , vol.25 , Issue.22 , pp. 5446-5454
    • Andorfer, C.1    Acker, C.M.2    Kress, Y.3    Hof, P.R.4    Duff, K.5    Davies, P.6
  • 4
    • 33749164973 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 5 in synaptic plasticity, learning and memory
    • DOI 10.1111/j.1471-4159.2006.04040.x
    • M Angelo F Plattner KP Giese 2006 Cyclin-dependent kinase 5 in synaptic plasticity, learning and memory J Neurochem 99 353 370 10.1111/j.1471-4159.2006. 04040.x 10.1111/j.1471-4159.2006.04040.x 17029592 1:CAS:528:DC%2BD28XhtF2rsLvN (Pubitemid 44477194)
    • (2006) Journal of Neurochemistry , vol.99 , Issue.2 , pp. 353-370
    • Angelo, M.1    Plattner, F.2    Giese, K.P.3
  • 5
    • 0034040825 scopus 로고    scopus 로고
    • Neurotrophic factors and pain
    • 10870734 1:STN:280:DC%2BD3cvpt1yjsg%3D%3D
    • SC Apfel 2000 Neurotrophic factors and pain Clin J Pain 16 S7 S11 10870734 1:STN:280:DC%2BD3cvpt1yjsg%3D%3D
    • (2000) Clin J Pain , vol.16
    • Apfel, S.C.1
  • 6
    • 0031018336 scopus 로고    scopus 로고
    • Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality
    • DOI 10.1016/S0896-6273(01)80044-1
    • T Chae YT Kwon R Bronson P Dikkes E Li LH Tsai 1997 Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality Neuron 18 29 42 10.1016/S0896-6273(01)80044-1 10.1016/S0896-6273(01)80044-1 9010203 1:CAS:528:DyaK2sXpslKktQ%3D%3D (Pubitemid 27053828)
    • (1997) Neuron , vol.18 , Issue.1 , pp. 29-42
    • Chae, T.1    Kwon, Y.T.2    Bronson, R.3    Dikkes, P.4    En, L.5    Tsai, L.-H.6
  • 7
    • 15244352198 scopus 로고    scopus 로고
    • Emerging role for ERK as a key regulator of neuronal apoptosis
    • 10.1126/stke.2512004pe45 10.1126/stke.2512004pe45 15383672
    • EC Cheung RS Slack 2004 Emerging role for ERK as a key regulator of neuronal apoptosis Sci STKE 2004 PE45 10.1126/stke.2512004pe45 10.1126/stke.2512004pe45 15383672
    • (2004) Sci STKE , vol.2004 , pp. 45
    • Cheung, E.C.1    Slack, R.S.2
  • 8
    • 44949105375 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 5 supports neuronal survival through phosphorylation of Bcl-2
    • 10.1523/JNEUROSCI.0689-08.2008 10.1523/JNEUROSCI.0689-08.2008 18463240 1:CAS:528:DC%2BD1cXlvFersbc%3D
    • ZH Cheung K Gong NY Ip 2008 Cyclin-dependent kinase 5 supports neuronal survival through phosphorylation of Bcl-2 J Neurosci 28 4872 4877 10.1523/JNEUROSCI.0689-08.2008 10.1523/JNEUROSCI.0689-08.2008 18463240 1:CAS:528:DC%2BD1cXlvFersbc%3D
    • (2008) J Neurosci , vol.28 , pp. 4872-4877
    • Cheung, Z.H.1    Gong, K.2    Ip, N.Y.3
  • 9
    • 27144478006 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 5 is essential for neuronal cell cycle arrest and differentiation
    • DOI 10.1523/JNEUROSCI.1773-05.2005
    • S Cicero K Herrup 2005 Cyclin-dependent kinase 5 is essential for neuronal cell cycle arrest and differentiation J Neurosci 25 9658 9668 10.1523/JNEUROSCI.1773-05.2005 10.1523/JNEUROSCI.1773-05.2005 16237170 1:CAS:528:DC%2BD2MXht1WqsrnJ (Pubitemid 41510906)
    • (2005) Journal of Neuroscience , vol.25 , Issue.42 , pp. 9658-9668
    • Cicero, S.1    Herrup, K.2
  • 12
    • 2942572871 scopus 로고    scopus 로고
    • A Jekyll and Hyde kinase: Roles for Cdk5 in brain development and disease
    • DOI 10.1016/j.conb.2004.05.002, PII S0959438804000698
    • JC Cruz LH Tsai 2004 A Jekyll and Hyde kinase: roles for Cdk5 in brain development and disease Curr Opin Neurobiol 14 390 394 10.1016/j.conb.2004.05. 002 10.1016/j.conb.2004.05.002 15194121 1:CAS:528:DC%2BD2cXkvV2ns70%3D (Pubitemid 38759871)
    • (2004) Current Opinion in Neurobiology , vol.14 , Issue.3 , pp. 390-394
    • Cruz, J.C.1    Tsai, L.-H.2
  • 13
    • 0345405447 scopus 로고    scopus 로고
    • Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles
    • DOI 10.1016/S0896-6273(03)00627-5
    • JC Cruz HC Tseng JA Goldman H Shih LH Tsai 2003 Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles Neuron 40 471 483 10.1016/S0896-6273(03)00627-5 10.1016/S0896-6273(03)00627-5 14642273 1:CAS:528:DC%2BD3sXptVylurk%3D (Pubitemid 37494698)
    • (2003) Neuron , vol.40 , Issue.3 , pp. 471-483
    • Cruz, J.C.1    Tseng, H.-C.2    Goldman, J.A.3    Shih, H.4    Tsai, L.-H.5
  • 14
    • 33749826587 scopus 로고    scopus 로고
    • P25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid β in vivo
    • DOI 10.1523/JNEUROSCI.3133-06.2006
    • JC Cruz D Kim LY Moy MM Dobbin X Sun RT Bronson LH Tsai 2006 p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid beta in vivo J Neurosci 26 10536 10541 10.1523/JNEUROSCI.3133-06.2006 10.1523/JNEUROSCI.3133-06.2006 17035538 1:CAS:528:DC%2BD28XhtFegurzJ (Pubitemid 44564604)
    • (2006) Journal of Neuroscience , vol.26 , Issue.41 , pp. 10536-10541
    • Cruz, J.C.1    Kim, D.2    Moy, L.Y.3    Dobbin, M.M.4    Sun, X.5    Bronson, R.T.6    Tsai, L.-H.7
  • 15
    • 0035489777 scopus 로고    scopus 로고
    • A decade of CDK5
    • DOI 10.1038/35096019
    • R Dhavan LH Tsai 2001 A decade of CDK5 Nat Rev Mol Cell Biol 2 749 759 10.1038/35096019 10.1038/35096019 11584302 1:CAS:528:DC%2BD3MXnvVajsLg%3D (Pubitemid 33679837)
    • (2001) Nature Reviews Molecular Cell Biology , vol.2 , Issue.10 , pp. 749-759
    • Dhavan, R.1    Tsai, L.-H.2
  • 16
    • 4644360412 scopus 로고    scopus 로고
    • MARKing tau for tangles and toxicity
    • DOI 10.1016/j.tibs.2004.08.001, PII S0968000404002026
    • G Drewes 2004 MARKing tau for tangles and toxicity Trends Biochem Sci 29 548 555 10.1016/j.tibs.2004.08.001 10.1016/j.tibs.2004.08.001 15450610 1:CAS:528:DC%2BD2cXnvVOhs7s%3D (Pubitemid 39265172)
    • (2004) Trends in Biochemical Sciences , vol.29 , Issue.10 , pp. 548-555
    • Drewes, G.1
  • 17
    • 47849121512 scopus 로고    scopus 로고
    • The damage signals hypothesis of Alzheimer's disease pathogenesis
    • 18599959 1:CAS:528:DC%2BD1cXns1amtrw%3D
    • JA Fernandez L Rojo RO Kuljis RB Maccioni 2008 The damage signals hypothesis of Alzheimer's disease pathogenesis J Alzheimers Dis 14 329 333 18599959 1:CAS:528:DC%2BD1cXns1amtrw%3D
    • (2008) J Alzheimers Dis , vol.14 , pp. 329-333
    • Fernandez, J.A.1    Rojo, L.2    Kuljis, R.O.3    MacCioni, R.B.4
  • 18
    • 0348010578 scopus 로고    scopus 로고
    • Cdk5: A novel role in learning and memory
    • DOI 10.1159/000074621
    • A Fischer F Sananbenesi J Spiess J Radulovic 2003 Cdk5: a novel role in learning and memory Neurosignals 12 200 208 10.1159/000074621 10.1159/000074621 14673206 1:CAS:528:DC%2BD3sXpslOis74%3D (Pubitemid 37548234)
    • (2003) NeuroSignals , vol.12 , Issue.4-5 , pp. 200-208
    • Fischer, A.1    Sananbenesi, F.2    Spiess, J.3    Radulovic, J.4
  • 19
    • 28744449248 scopus 로고    scopus 로고
    • Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory
    • DOI 10.1016/j.neuron.2005.10.033, PII S0896627305009517
    • A Fischer F Sananbenesi PT Pang B Lu LH Tsai 2005 Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory Neuron 48 825 838 10.1016/j.neuron.2005.10.033 10.1016/j.neuron.2005.10.033 16337919 1:CAS:528:DC%2BD2MXhtleksL7F (Pubitemid 41759432)
    • (2005) Neuron , vol.48 , Issue.5 , pp. 825-838
    • Fischer, A.1    Sananbenesi, F.2    Pang, P.T.3    Lu, B.4    Tsai, L.-H.5
  • 20
    • 0036731701 scopus 로고    scopus 로고
    • Mixed-lineage kinase control of JNK and p38 MAPK pathways
    • DOI 10.1038/nrm906
    • KA Gallo GL Johnson 2002 Mixed-lineage kinase control of JNK and p38 MAPK pathways Nat Rev Mol Cell Biol 3 663 672 10.1038/nrm906 10.1038/nrm906 12209126 1:CAS:528:DC%2BD38Xmslagu7o%3D (Pubitemid 34987787)
    • (2002) Nature Reviews Molecular Cell Biology , vol.3 , Issue.9 , pp. 663-672
    • Gallo, K.A.1    Johnson, G.L.2
  • 21
    • 33846919884 scopus 로고    scopus 로고
    • Concise review: Therapeutic strategies for Parkinson disease based on the modulation of adult neurogenesis
    • DOI 10.1634/stemcells.2006-0364
    • M Geraerts O Krylyshkina Z Debyser V Baekelandt 2007 Concise review: therapeutic strategies for Parkinson disease based on the modulation of adult neurogenesis Stem Cells 25 263 270 10.1634/stemcells.2006-0364 10.1634/stemcells.2006-0364 17082225 1:CAS:528:DC%2BD2sXivVOlsbs%3D (Pubitemid 46232779)
    • (2007) Stem Cells , vol.25 , Issue.2 , pp. 263-270
    • Geraerts, M.1    Krylyshkina, O.2    Debyser, Z.3    Baekelandt, V.4
  • 22
    • 0034304948 scopus 로고    scopus 로고
    • Neurogenesis in the adult brain: Death of a dogma
    • 10.1038/35036235 10.1038/35036235 11252770 1:CAS:528:DC%2BD3MXivVSjs7o%3D
    • CG Gross 2000 Neurogenesis in the adult brain: death of a dogma Nat Rev Neurosci 1 67 73 10.1038/35036235 10.1038/35036235 11252770 1:CAS:528: DC%2BD3MXivVSjs7o%3D
    • (2000) Nat Rev Neurosci , vol.1 , pp. 67-73
    • Gross, C.G.1
  • 23
    • 33847662852 scopus 로고    scopus 로고
    • Soluble protein oligomers in neurodegeneration: Lessons from the Alzheimer's amyloid β-peptide
    • DOI 10.1038/nrm2101, PII NRM2101
    • C Haass DJ Selkoe 2007 Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide Nat Rev Mol Cell Biol 8 101 112 10.1038/nrm2101 10.1038/nrm2101 17245412 1:CAS:528:DC%2BD2sXotFKmtw%3D%3D (Pubitemid 46432529)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.2 , pp. 101-112
    • Haass, C.1    Selkoe, D.J.2
  • 24
    • 0344011447 scopus 로고    scopus 로고
    • Decreased cyclin-dependent kinase 5 (cdk5) activity is accompanied by redistribution of cdk5 and cytoskeletal proteins and increased cytoskeletal protein phosphorylation in p35 null mice
    • 14627648 1:CAS:528:DC%2BD3sXpsFGjurs%3D
    • JL Hallows K Chen RA DePinho I Vincent 2003 Decreased cyclin-dependent kinase 5 (cdk5) activity is accompanied by redistribution of cdk5 and cytoskeletal proteins and increased cytoskeletal protein phosphorylation in p35 null mice J Neurosci 23 10633 10644 14627648 1:CAS:528:DC%2BD3sXpsFGjurs%3D
    • (2003) J Neurosci , vol.23 , pp. 10633-10644
    • Hallows, J.L.1    Chen, K.2    Depinho, R.A.3    Vincent, I.4
  • 25
    • 0035021950 scopus 로고    scopus 로고
    • ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1
    • DOI 10.1038/35074516
    • T Harada T Morooka S Ogawa E Nishida 2001 ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1 Nat Cell Biol 3 453 459 10.1038/35074516 10.1038/35074516 11331872 1:CAS:528:DC%2BD3MXjsFCksr8%3D (Pubitemid 32422080)
    • (2001) Nature Cell Biology , vol.3 , Issue.5 , pp. 453-459
    • Harada, T.1    Morooka, T.2    Ogawa, S.3    Nishida, E.4
  • 26
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • DOI 10.1126/science.1072994
    • J Hardy DJ Selkoe 2002 The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics Science 297 353 356 10.1126/science.1072994 10.1126/science.1072994 12130773 1:CAS:528: DC%2BD38Xls1Cju7s%3D (Pubitemid 34790756)
    • (2002) Science , vol.297 , Issue.5580 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 27
    • 0347785492 scopus 로고    scopus 로고
    • 205 of human tau
    • DOI 10.1074/jbc.M207426200
    • M Hashiguchi T Saito S Hisanaga T Hashiguchi 2002 Truncation of CDK5 activator p35 induces intensive phosphorylation of Ser202/Thr205 of human tau J Biol Chem 277 44525 44530 10.1074/jbc.M207426200 10.1074/jbc.M207426200 12226093 1:CAS:528:DC%2BD38Xos1akur0%3D (Pubitemid 36157887)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.46 , pp. 44525-44530
    • Hashiguchi, M.1    Saito, T.2    Hisanaga, S.-I.3    Hashiguchi, T.4
  • 28
    • 0027178335 scopus 로고
    • Cell death and the cell cycle: A relationship between transformation and neurodegeneration?
    • DOI 10.1016/0968-0004(93)90103-T
    • N Heintz 1993 Cell death and the cell cycle: a relationship between transformation and neurodegeneration? Trends Biochem Sci 18 157 159 10.1016/0968-0004(93)90103-T 10.1016/0968-0004(93)90103-T 8328013 1:STN:280:DyaK3szhvVartA%3D%3D (Pubitemid 23142567)
    • (1993) Trends in Biochemical Sciences , vol.18 , Issue.5 , pp. 157-159
    • Heintz, N.1
  • 29
    • 41549165086 scopus 로고    scopus 로고
    • A new take on prions: Preventing Alzheimer's disease
    • 10.1016/j.tibs.2008.01.004 10.1016/j.tibs.2008.01.004 18343669 1:CAS:528:DC%2BD1cXktlCkur0%3D
    • NM Hooper AJ Turner 2008 A new take on prions: preventing Alzheimer's disease Trends Biochem Sci 33 151 155 10.1016/j.tibs.2008.01.004 10.1016/j.tibs.2008.01.004 18343669 1:CAS:528:DC%2BD1cXktlCkur0%3D
    • (2008) Trends Biochem Sci , vol.33 , pp. 151-155
    • Hooper, N.M.1    Turner, A.J.2
  • 30
    • 0033836219 scopus 로고    scopus 로고
    • Neuron-specific phosphorylation of Alzheimer's β-amyloid precursor protein by cyclin-dependent kinase 5
    • DOI 10.1046/j.1471-4159.2000.0751085.x
    • K Iijima K Ando S Takeda Y Satoh T Seki S Itohara P Greengard Y Kirino AC Nairn T Suzuki 2000 Neuron-specific phosphorylation of Alzheimer's beta-amyloid precursor protein by cyclin-dependent kinase 5 J Neurochem 75 1085 1091 10.1046/j.1471-4159.2000.0751085.x 10.1046/j.1471-4159.2000.0751085.x 10936190 1:CAS:528:DC%2BD3cXmtFyrs74%3D (Pubitemid 30660497)
    • (2000) Journal of Neurochemistry , vol.75 , Issue.3 , pp. 1085-1091
    • Iijima, K.-I.1    Ando, K.2    Takeda, S.3    Satoh, Y.4    Seki, T.5    Itohara, S.6    Greengard, P.7    Kirino, Y.8    Nairn, A.C.9    Suzuki, T.10
  • 31
    • 0031045216 scopus 로고    scopus 로고
    • Physiology and pathology of tau protein kinases in relation to Alzheimer's disease
    • 9089387 1:CAS:528:DyaK2sXislSrsLs%3D
    • K Imahori T Uchida 1997 Physiology and pathology of tau protein kinases in relation to Alzheimer's disease J Biochem 121 179 188 9089387 1:CAS:528:DyaK2sXislSrsLs%3D
    • (1997) J Biochem , vol.121 , pp. 179-188
    • Imahori, K.1    Uchida, T.2
  • 32
    • 0042425738 scopus 로고    scopus 로고
    • Co-localization of glycogen synthase kinase-3 with neurofibrillary tangles and granulovacuolar degeneration in transgenic mice
    • 12937146 1:CAS:528:DC%2BD3sXnsVCisr0%3D
    • T Ishizawa N Sahara K Ishiguro J Kersh E McGowan J Lewis M Hutton DW Dickson SH Yen 2003 Co-localization of glycogen synthase kinase-3 with neurofibrillary tangles and granulovacuolar degeneration in transgenic mice Am J Pathol 163 1057 1067 12937146 1:CAS:528:DC%2BD3sXnsVCisr0%3D
    • (2003) Am J Pathol , vol.163 , pp. 1057-1067
    • Ishizawa, T.1    Sahara, N.2    Ishiguro, K.3    Kersh, J.4    McGowan, E.5    Lewis, J.6    Hutton, M.7    Dickson, D.W.8    Yen, S.H.9
  • 33
    • 12344323961 scopus 로고    scopus 로고
    • Tau phosphorylation in neuronal cell function and dysfunction
    • DOI 10.1242/jcs.01558
    • GV Johnson WH Stoothoff 2004 Tau phosphorylation in neuronal cell function and dysfunction J Cell Sci 117 5721 5729 10.1242/jcs.01558 10.1242/jcs.01558 15537830 1:CAS:528:DC%2BD2MXlvFShtw%3D%3D (Pubitemid 40123939)
    • (2004) Journal of Cell Science , vol.117 , Issue.24 , pp. 5721-5729
    • Johnson, G.V.W.1    Stoothoff, W.H.2
  • 35
    • 2342494271 scopus 로고    scopus 로고
    • P35/Cyclin-Dependent Kinase 5 Phosphorylation of Ras Guanine Nucleotide Releasing Factor 2 (RasGRF2) Mediates Rac-Dependent Extracellular Signal-Regulated Kinase 1/2 Activity, Altering RasGRF2 and Microtubule- Associated Protein 1b Distribution in Neurons
    • DOI 10.1523/JNEUROSCI.0690-04.2004
    • S Kesavapany N Amin YL Zheng R Nijhara H Jaffe R Sihag JS Gutkind S Takahashi A Kulkarni P Grant HC Pant 2004 p35/cyclin-dependent kinase 5 phosphorylation of ras guanine nucleotide releasing factor 2 (RasGRF2) mediates Rac-dependent Extracellular Signal-regulated kinase 1/2 activity, altering RasGRF2 and microtubule-associated protein 1b distribution in neurons J Neurosci 24 4421 4431 10.1523/JNEUROSCI.0690-04.2004 10.1523/JNEUROSCI.0690-04.2004 15128856 1:CAS:528:DC%2BD2cXktFCjtLY%3D (Pubitemid 38608153)
    • (2004) Journal of Neuroscience , vol.24 , Issue.18 , pp. 4421-4431
    • Kesavapany, S.1    Amin, N.2    Zheng, Y.-L.3    Nijhara, R.4    Jaffe, H.5    Sihag, R.6    Gutkind, J.S.7    Takahashi, S.8    Kulkarni, A.9    Grant, P.10    Pant, H.C.11
  • 36
    • 34250184630 scopus 로고    scopus 로고
    • Neuronal nuclear organization is controlled by cyclin-dependent kinase 5 phosphorylation of Ras guanine nucleotide releasing factor-1
    • DOI 10.1159/000095130
    • S Kesavapany TK Pareek YL Zheng N Amin JS Gutkind W Ma AB Kulkarni P Grant HC Pant 2006 Neuronal nuclear organization is controlled by cyclin-dependent kinase 5 phosphorylation of Ras Guanine nucleotide releasing factor-1 Neurosignals 15 157 173 10.1159/000095130 10.1159/000095130 16921254 1:CAS:528:DC%2BD2sXmt1Squr8%3D (Pubitemid 46895637)
    • (2006) NeuroSignals , vol.15 , Issue.4 , pp. 157-173
    • Kesavapany, S.1    Pareek, T.K.2    Zheng, Y.-L.3    Amin, N.4    Gutkind, J.S.5    Ma, W.6    Kulkarni, A.B.7    Grant, P.8    Pant, H.C.9
  • 38
    • 0035448915 scopus 로고    scopus 로고
    • P35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment
    • 11517264 1:CAS:528:DC%2BD3MXmt1Wisrs%3D
    • J Ko S Humbert RT Bronson S Takahashi AB Kulkarni E Li LH Tsai 2001 p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment J Neurosci 21 6758 6771 11517264 1:CAS:528:DC%2BD3MXmt1Wisrs%3D
    • (2001) J Neurosci , vol.21 , pp. 6758-6771
    • Ko, J.1    Humbert, S.2    Bronson, R.T.3    Takahashi, S.4    Kulkarni, A.B.5    Li, E.6    Tsai, L.H.7
  • 39
    • 0034682414 scopus 로고    scopus 로고
    • Neurotoxicity induces cleavage of p35 to p25 by calpain
    • DOI 10.1038/35012636
    • MS Lee YT Kwon M Li J Peng RM Friedlander LH Tsai 2000 Neurotoxicity induces cleavage of p35 to p25 by calpain Nature 405 360 364 10.1038/35012636 10.1038/35012636 10830966 1:CAS:528:DC%2BD3cXjs1Kqsrk%3D (Pubitemid 30337070)
    • (2000) Nature , vol.405 , Issue.6784 , pp. 360-364
    • Lee, M.-S.1    Kwon, Y.T.2    Li, M.3    Peng, J.4    Friedlander, R.M.5    Tsai, L.-H.6
  • 41
    • 0037336701 scopus 로고    scopus 로고
    • Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway
    • 12629164 1:CAS:528:DC%2BD3sXjtFylt7c%3D
    • Y Li L Liu SW Barger WS Griffin 2003 Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway J Neurosci 23 1605 1611 12629164 1:CAS:528:DC%2BD3sXjtFylt7c%3D
    • (2003) J Neurosci , vol.23 , pp. 1605-1611
    • Li, Y.1    Liu, L.2    Barger, S.W.3    Griffin, W.S.4
  • 42
    • 0034829801 scopus 로고    scopus 로고
    • The molecular bases of Alzheimer's disease and other neurodegenerative disorders
    • DOI 10.1016/S0188-4409(01)00316-2, PII S0188440901003162
    • RB Maccioni JP Munoz L Barbeito 2001 The molecular bases of Alzheimer's disease and other neurodegenerative disorders Arch Med Res 32 367 381 10.1016/S0188-4409(01)00316-2 10.1016/S0188-4409(01)00316-2 11578751 1:CAS:528:DC%2BD3MXnslKhtrk%3D (Pubitemid 32918139)
    • (2001) Archives of Medical Research , vol.32 , Issue.5 , pp. 367-381
    • Maccioni, R.B.1    Munoz, J.P.2    Barbeito, L.3
  • 45
    • 0036469290 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3 phosphorylates kinesin light chains and negatively regulates kinesin-based motility
    • DOI 10.1093/emboj/21.3.281
    • G Morfini G Szebenyi R Elluru N Ratner ST Brady 2002 Glycogen synthase kinase 3 phosphorylates kinesin light chains and negatively regulates kinesin-based motility EMBO J 21 281 293 10.1093/emboj/21.3.281 10.1093/emboj/21.3.281 11823421 1:CAS:528:DC%2BD38XhsVSnsro%3D (Pubitemid 34137290)
    • (2002) EMBO Journal , vol.21 , Issue.3 , pp. 281-293
    • Morfini, G.1    Szebenyi, G.2    Elluru, R.3    Ratner, N.4    Brady, S.T.5
  • 46
    • 3042634127 scopus 로고    scopus 로고
    • A novel CDK5-dependent pathway for regulating GSK3 activity and kinesin-driven motility in neurons
    • DOI 10.1038/sj.emboj.7600237
    • G Morfini G Szebenyi H Brown HC Pant G Pigino S DeBoer U Beffert ST Brady 2004 A novel CDK5-dependent pathway for regulating GSK3 activity and kinesin-driven motility in neurons EMBO J 23 2235 2245 10.1038/sj.emboj.7600237 15152189 1:CAS:528:DC%2BD2cXksV2htrw%3D (Pubitemid 38833233)
    • (2004) EMBO Journal , vol.23 , Issue.11 , pp. 2235-2245
    • Morfini, G.1    Szebenyi, G.2    Brown, H.3    Pant, H.C.4    Pigino, G.5    DeBoer, S.6    Beffert, U.7    Brady, S.T.8
  • 47
    • 0029809808 scopus 로고    scopus 로고
    • P53-independent cyclin G expression in a group of mature neurons and its enhanced expression during nerve regeneration
    • 8815878 1:CAS:528:DyaK28XntlartLs%3D
    • N Morita S Kiryu H Kiyama 1996 p53-independent cyclin G expression in a group of mature neurons and its enhanced expression during nerve regeneration J Neurosci 16 5961 5966 8815878 1:CAS:528:DyaK28XntlartLs%3D
    • (1996) J Neurosci , vol.16 , pp. 5961-5966
    • Morita, N.1    Kiryu, S.2    Kiyama, H.3
  • 48
    • 0033634990 scopus 로고    scopus 로고
    • Cell cycle regulatory failure in neurones: Causes and consequences
    • 10.1016/S0197-4580(00)00223-2 10.1016/S0197-4580(00)00223-2 11124420 1:CAS:528:DC%2BD3cXovFGqu74%3D
    • Z Nagy 2000 Cell cycle regulatory failure in neurones: causes and consequences Neurobiol Aging 21 761 769 10.1016/S0197-4580(00)00223-2 10.1016/S0197-4580(00)00223-2 11124420 1:CAS:528:DC%2BD3cXovFGqu74%3D
    • (2000) Neurobiol Aging , vol.21 , pp. 761-769
    • Nagy, Z.1
  • 49
    • 33845722640 scopus 로고    scopus 로고
    • An essential role for the integrin-linked kinase-glycogen synthase kinase-3β pathway during dendrite initiation and growth
    • DOI 10.1523/JNEUROSCI.4462-06.2006
    • S Naska KJ Park GE Hannigan S Dedhar FD Miller DR Kaplan 2006 An essential role for the integrin-linked kinase-glycogen synthase kinase-3 beta pathway during dendrite initiation and growth J Neurosci 26 13344 13356 10.1523/JNEUROSCI.4462-06.2006 10.1523/JNEUROSCI.4462-06.2006 17182785 1:CAS:528:DC%2BD2sXjsFalug%3D%3D (Pubitemid 46011645)
    • (2006) Journal of Neuroscience , vol.26 , Issue.51 , pp. 13344-13356
    • Naska, S.1    Park, K.J.2    Hannigan, G.E.3    Dedhar, S.4    Miller, F.D.5    Kaplan, D.R.6
  • 50
    • 12244303616 scopus 로고    scopus 로고
    • Cycling at the interface between neurodevelopment and neurodegeneration
    • DOI 10.1038/sj.cdd.4401108
    • MD Nguyen WE Mushynski JP Julien 2002 Cycling at the interface between neurodevelopment and neurodegeneration Cell Death Differ 9 1294 1306 10.1038/sj.cdd.4401108 10.1038/sj.cdd.4401108 12478466 1:CAS:528: DC%2BD38XpsVSrsb8%3D (Pubitemid 36097699)
    • (2002) Cell Death and Differentiation , vol.9 , Issue.12 , pp. 1294-1306
    • Nguyen, M.D.1    Mushynski, W.E.2    Julien, J.-P.3
  • 52
    • 56349125650 scopus 로고    scopus 로고
    • Interleukin-18 increases expression of kinases involved in tau phosphorylation in SH-SY5Y neuroblastoma cells
    • 10.1016/j.jneuroim.2008.09.012 10.1016/j.jneuroim.2008.09.012 18947885 1:CAS:528:DC%2BD1cXhsVWrsbzN
    • JO Ojala EM Sutinen A Salminen T Pirttila 2008 Interleukin-18 increases expression of kinases involved in tau phosphorylation in SH-SY5Y neuroblastoma cells J Neuroimmunol 205 86 93 10.1016/j.jneuroim.2008.09.012 10.1016/j.jneuroim.2008.09.012 18947885 1:CAS:528:DC%2BD1cXhsVWrsbzN
    • (2008) J Neuroimmunol , vol.205 , pp. 86-93
    • Ojala, J.O.1    Sutinen, E.M.2    Salminen, A.3    Pirttila, T.4
  • 53
    • 0027944251 scopus 로고
    • Cyclin G is a transcriptional target of the p53 tumor suppressor protein
    • 7957050 1:CAS:528:DyaK2MXhvF2iu7w%3D
    • K Okamoto D Beach 1994 Cyclin G is a transcriptional target of the p53 tumor suppressor protein EMBO J 13 4816 4822 7957050 1:CAS:528: DyaK2MXhvF2iu7w%3D
    • (1994) EMBO J , vol.13 , pp. 4816-4822
    • Okamoto, K.1    Beach, D.2
  • 55
    • 0033540060 scopus 로고    scopus 로고
    • Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration
    • 10.1038/45159 10.1038/45159 10604467 1:CAS:528:DC%2BD3cXjsVGq
    • GN Patrick L Zukerberg M Nikolic S de la Monte P Dikkes LH Tsai 1999 Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration Nature 402 615 622 10.1038/45159 10.1038/45159 10604467 1:CAS:528:DC%2BD3cXjsVGq
    • (1999) Nature , vol.402 , pp. 615-622
    • Patrick, G.N.1    Zukerberg, L.2    Nikolic, M.3    De La Monte, S.4    Dikkes, P.5    Tsai, L.H.6
  • 56
    • 0037040934 scopus 로고    scopus 로고
    • Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29
    • DOI 10.1074/jbc.M109645200
    • H Patzke LH Tsai 2002 Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29 J Biol Chem 277 8054 8060 10.1074/jbc.M109645200 10.1074/jbc.M109645200 11784720 1:CAS:528:DC%2BD38XitFymsL0%3D (Pubitemid 34968258)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.10 , pp. 8054-8060
    • Patzke, H.1    Tsai, L.-H.2
  • 57
    • 0038187674 scopus 로고    scopus 로고
    • GSK-3α regulates production of Alzheimer's disease amyloid-β peptides
    • DOI 10.1038/nature01640
    • CJ Phiel CA Wilson VM Lee PS Klein 2003 GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides Nature 423 435 439 10.1038/nature01640 10.1038/nature01640 12761548 1:CAS:528:DC%2BD3sXjvFaltLY%3D (Pubitemid 36626994)
    • (2003) Nature , vol.423 , Issue.6938 , pp. 435-439
    • Phiel, C.J.1    Wilson, C.A.2    Lee, V.M.-Y.3    Klein, P.S.4
  • 58
    • 1642420308 scopus 로고    scopus 로고
    • Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5/p35 pathway
    • DOI 10.1016/j.yexcr.2004.01.002, PII S0014482704000187
    • RA Quintanilla DI Orellana C Gonzalez-Billault RB Maccioni 2004 Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5/p35 pathway Exp Cell Res 295 245 257 10.1016/j.yexcr.2004. 01.002 10.1016/j.yexcr.2004.01.002 15051507 1:CAS:528:DC%2BD2cXis1Wgs7w%3D (Pubitemid 38407361)
    • (2004) Experimental Cell Research , vol.295 , Issue.1 , pp. 245-257
    • Quintanilla, R.A.1    Orellana, D.I.2    Gonzalez-Billault, C.3    Maccioni, R.B.4
  • 59
    • 36549083642 scopus 로고    scopus 로고
    • Neuroinflammation: Implications for the pathogenesis and molecular diagnosis of alzheimer's disease
    • DOI 10.1016/j.arcmed.2007.10.001, PII S0188440907003268
    • LE Rojo JA Fernandez AA Maccioni JM Jimenez RB Maccioni 2008 Neuroinflammation: implications for the pathogenesis and molecular diagnosis of Alzheimer's disease Arch Med Res 39 1 16 10.1016/j.arcmed.2007.10.001 10.1016/j.arcmed.2007.10.001 18067990 1:CAS:528:DC%2BD2sXhsVSmtbvM (Pubitemid 350192021)
    • (2008) Archives of Medical Research , vol.39 , Issue.1 , pp. 1-16
    • Rojo, L.E.1    Fernandez, J.A.2    Maccioni, A.A.3    Jimenez, J.M.4    Maccioni, R.B.5
  • 60
    • 55549124552 scopus 로고    scopus 로고
    • Pin1-dependent prolyl isomerization modulates the stress-induced phosphorylation of high molecular weight neurofilament protein
    • 10.1074/jbc.M801633200 10.1074/jbc.M801633200 18635547 1:CAS:528:DC%2BD1cXhtFejtrrI
    • P Rudrabhatla YL Zheng ND Amin S Kesavapany W Albers HC Pant 2008 Pin1-dependent prolyl isomerization modulates the stress-induced phosphorylation of high molecular weight neurofilament protein J Biol Chem 283 26737 26747 10.1074/jbc.M801633200 10.1074/jbc.M801633200 18635547 1:CAS:528: DC%2BD1cXhtFejtrrI
    • (2008) J Biol Chem , vol.283 , pp. 26737-26747
    • Rudrabhatla, P.1    Zheng, Y.L.2    Amin, N.D.3    Kesavapany, S.4    Albers, W.5    Pant, H.C.6
  • 61
    • 0037133720 scopus 로고    scopus 로고
    • Ik3-2, a relative to ik3-1/cables, is associated with cdk3, cdk5, and c-abl
    • 11955625 1:CAS:528:DC%2BD38XktVKgtbw%3D
    • H Sato I Nishimoto M Matsuoka 2002 Ik3-2, a relative to ik3-1/cables, is associated with cdk3, cdk5, and c-abl Biochim Biophys Acta 1574 157 163 11955625 1:CAS:528:DC%2BD38XktVKgtbw%3D
    • (2002) Biochim Biophys Acta , vol.1574 , pp. 157-163
    • Sato, H.1    Nishimoto, I.2    Matsuoka, M.3
  • 62
    • 33747342080 scopus 로고    scopus 로고
    • Enhanced de novo neurogenesis and dopaminergic neurogenesis in the substantia nigra of 1-methyl-4-phyenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease-like mice
    • DOI 10.1634/stemcells.2005-0487
    • X Shan L Chi M Bishop C Luo L Lien Z Zhang R Liu 2006 Enhanced de novo neurogenesis and dopaminergic neurogenesis in the substantia nigra of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced Parkinson's disease-like mice Stem Cells 24 1280 1287 10.1634/stemcells.2005-0487 10.1634/stemcells. 2005-0487 16424396 1:CAS:528:DC%2BD28XhtFGhu7fP (Pubitemid 44464697)
    • (2006) Stem Cells , vol.24 , Issue.5 , pp. 1280-1287
    • Shan, X.1    Chi, L.2    Bishop, M.3    Luo, C.4    Lien, L.5    Zhang, Z.6    Liu, R.7
  • 63
    • 0037016678 scopus 로고    scopus 로고
    • Phosphorylation of MEK1 by cdk5/p35 down-regulates the mitogen-activated protein kinase pathway
    • DOI 10.1074/jbc.M109324200
    • P Sharma Veeranna M Sharma ND Amin RK Sihag P Grant N Ahn AB Kulkarni HC Pant 2002 Phosphorylation of MEK1 by cdk5/p35 down-regulates the mitogen-activated protein kinase pathway J Biol Chem 277 528 534 10.1074/jbc.M109324200 10.1074/jbc.M109324200 11684694 1:CAS:528: DC%2BD38XjslGnsg%3D%3D (Pubitemid 34952088)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.1 , pp. 528-534
    • Sharma, P.1    Veeranna, V.2    Sharma, M.3    Amin, N.D.4    Sihag, R.K.5    Grant, P.6    Ahn, N.7    Kulkarni, A.B.8    Pant, H.C.9
  • 64
    • 1642269125 scopus 로고    scopus 로고
    • Cyclin-dependent kinase-5 in neurodegeneration
    • 15009631 1:CAS:528:DC%2BD2cXivVCit7w%3D
    • SB Shelton GV Johnson 2004 Cyclin-dependent kinase-5 in neurodegeneration J Neurochem 88 1313 1326 15009631 1:CAS:528:DC%2BD2cXivVCit7w%3D
    • (2004) J Neurochem , vol.88 , pp. 1313-1326
    • Shelton, S.B.1    Johnson, G.V.2
  • 65
    • 0027165323 scopus 로고
    • Cdc2-like kinase from rat spinal cord specifically phosphorylates KSPXK motifs in neurofilament proteins: Isolation and characterization
    • 10.1073/pnas.90.14.6844 10.1073/pnas.90.14.6844 8341707 1:CAS:528:DyaK3sXlvFyhs7o%3D
    • KT Shetty WT Link HC Pant 1993 Cdc2-like kinase from rat spinal cord specifically phosphorylates KSPXK motifs in neurofilament proteins: isolation and characterization Proc Natl Acad Sci USA 90 6844 6848 10.1073/pnas.90.14.6844 10.1073/pnas.90.14.6844 8341707 1:CAS:528:DyaK3sXlvFyhs7o%3D
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 6844-6848
    • Shetty, K.T.1    Link, W.T.2    Pant, H.C.3
  • 66
    • 62549153549 scopus 로고    scopus 로고
    • Cyclin-dependent kinase-5 targeting for ischaemic stroke
    • 10.1016/j.coph.2008.10.003 18983942 1:CAS:528:DC%2BD1MXjsFahsbs%3D
    • M Slevin J Krupinski 2008 Cyclin-dependent kinase-5 targeting for ischaemic stroke Curr Opin Pharmacol 9 119 124 10.1016/j.coph.2008.10.003 18983942 1:CAS:528:DC%2BD1MXjsFahsbs%3D
    • (2008) Curr Opin Pharmacol , vol.9 , pp. 119-124
    • Slevin, M.1    Krupinski, J.2
  • 67
    • 33947597898 scopus 로고    scopus 로고
    • Regional expression of key cell cycle proteins in brain from subjects with amnestic mild cognitive impairment
    • DOI 10.1007/s11064-006-9123-x
    • R Sultana DA Butterfield 2007 Regional expression of key cell cycle proteins in brain from subjects with amnestic mild cognitive impairment Neurochem Res 32 655 662 10.1007/s11064-006-9123-x 10.1007/s11064-006-9123-x 17006763 1:CAS:528:DC%2BD2sXjtlynu7k%3D (Pubitemid 46481287)
    • (2007) Neurochemical Research , vol.32 , Issue.4-5 , pp. 655-662
    • Sultana, R.1    Butterfield, D.A.2
  • 68
    • 51349098209 scopus 로고    scopus 로고
    • Novel genetic tools reveal Cdk5's major role in golgi fragmentation in Alzheimer's disease
    • 10.1091/mbc.E07-11-1106 10.1091/mbc.E07-11-1106 18480410 1:CAS:528:DC%2BD1cXoslWitbs%3D
    • KH Sun Y de Pablo F Vincent EO Johnson AK Chavers K Shah 2008 Novel genetic tools reveal Cdk5's major role in golgi fragmentation in Alzheimer's disease Mol Biol Cell 19 3052 3069 10.1091/mbc.E07-11-1106 10.1091/mbc.E07-11- 1106 18480410 1:CAS:528:DC%2BD1cXoslWitbs%3D
    • (2008) Mol Biol Cell , vol.19 , pp. 3052-3069
    • Sun, K.H.1    De Pablo, Y.2    Vincent, F.3    Johnson, E.O.4    Chavers, A.K.5    Shah, K.6
  • 69
    • 0037855706 scopus 로고    scopus 로고
    • Tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubules
    • DOI 10.1074/jbc.M211964200
    • S Takahashi T Saito S Hisanaga HC Pant AB Kulkarni 2003 Tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubules J Biol Chem 278 10506 10515 10.1074/jbc.M211964200 10.1074/jbc.M211964200 12536148 1:CAS:528: DC%2BD3sXitVCrtbg%3D (Pubitemid 36800318)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.12 , pp. 10506-10515
    • Takahashi, S.1    Saito, T.2    Hisanaga, S.-I.3    Pant, H.C.4    Kulkarni, A.B.5
  • 70
    • 0032491416 scopus 로고    scopus 로고
    • Embryonic stem cell lines derived from human blastocysts
    • 10.1126/science.282.5391.1145 10.1126/science.282.5391.1145 9804556 1:CAS:528:DyaK1cXntleisLg%3D
    • JA Thomson J Itskovitz-Eldor SS Shapiro MA Waknitz JJ Swiergiel VS Marshall JM Jones 1998 Embryonic stem cell lines derived from human blastocysts Science 282 1145 1147 10.1126/science.282.5391.1145 10.1126/science.282.5391. 1145 9804556 1:CAS:528:DyaK1cXntleisLg%3D
    • (1998) Science , vol.282 , pp. 1145-1147
    • Thomson, J.A.1    Itskovitz-Eldor, J.2    Shapiro, S.S.3    Waknitz, M.A.4    Swiergiel, J.J.5    Marshall, V.S.6    Jones, J.M.7
  • 72
    • 0035110154 scopus 로고    scopus 로고
    • Coexpression of human cdk5 and its activator p35 with human protein tau in neurons in brain of triple transgenic mice
    • DOI 10.1006/nbdi.2000.0333
    • C Van den Haute K Spittaels J Van Dorpe R Lasrado K Vandezande I Laenen H Geerts F Van Leuven 2001 Coexpression of human cdk5 and its activator p35 with human protein tau in neurons in brain of triple transgenic mice Neurobiol Dis 8 32 44 10.1006/nbdi.2000.0333 10.1006/nbdi.2000.0333 11162238 1:CAS:528:DC%2BD3MXpvVSrsw%3D%3D (Pubitemid 32171816)
    • (2001) Neurobiology of Disease , vol.8 , Issue.1 , pp. 32-44
    • Van Den Haute, C.1    Spittaels, K.2    Van Dorpe, J.3    Lasrado, R.4    Vandezande, K.5    Laenen, I.6    Geerts, H.7    Van Leuven, F.8
  • 73
    • 48149096591 scopus 로고    scopus 로고
    • Probing novel 1-aza-9-oxafluorenes as selective GSK-3beta inhibitors
    • 10.1002/cmdc.200700175 10.1002/cmdc.200700175 18000938 1:CAS:528:DC%2BD1cXlt1Kqs7Y%3D
    • B Voigt M Krug C Schachtele F Totzke A Hilgeroth 2008 Probing novel 1-aza-9-oxafluorenes as selective GSK-3beta inhibitors ChemMedChem 3 120 126 10.1002/cmdc.200700175 10.1002/cmdc.200700175 18000938 1:CAS:528: DC%2BD1cXlt1Kqs7Y%3D
    • (2008) ChemMedChem , vol.3 , pp. 120-126
    • Voigt, B.1    Krug, M.2    Schachtele, C.3    Totzke, F.4    Hilgeroth, A.5
  • 74
    • 33745192268 scopus 로고    scopus 로고
    • Cyclin-dependent kinase-5 prevents neuronal apoptosis through ERK-mediated upregulation of Bcl-2
    • DOI 10.1038/sj.cdd.4401804, PII 4401804
    • CX Wang JH Song DK Song VW Yong A Shuaib C Hao 2006 Cyclin-dependent kinase-5 prevents neuronal apoptosis through ERK-mediated upregulation of Bcl-2 Cell Death Differ 13 1203 1212 10.1038/sj.cdd.4401804 10.1038/sj.cdd.4401804 16273078 1:CAS:528:DC%2BD28Xls1Khsbc%3D (Pubitemid 43905600)
    • (2006) Cell Death and Differentiation , vol.13 , Issue.7 , pp. 1203-1212
    • Wang, C.X.1    Song, J.H.2    Song, D.K.3    Yong, V.W.4    Shuaib, A.5    Hao, C.6
  • 75
    • 33947105676 scopus 로고    scopus 로고
    • Cdk5 is involved in NFT-like tauopathy induced by transient cerebral ischemia in female rats
    • 17113760 1:CAS:528:DC%2BD2sXjtVahu78%3D
    • Y Wen SH Yang R Liu EJ Perez AM Brun-Zinkernagel P Koulen JW Simpkins 2007 Cdk5 is involved in NFT-like tauopathy induced by transient cerebral ischemia in female rats Biochim Biophys Acta 1772 473 483 17113760 1:CAS:528:DC%2BD2sXjtVahu78%3D
    • (2007) Biochim Biophys Acta , vol.1772 , pp. 473-483
    • Wen, Y.1    Yang, S.H.2    Liu, R.3    Perez, E.J.4    Brun-Zinkernagel, A.M.5    Koulen, P.6    Simpkins, J.W.7
  • 76
    • 0035891271 scopus 로고    scopus 로고
    • The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcription
    • DOI 10.1038/35104575
    • Z Yang Q Zhu K Luo Q Zhou 2001 The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcription Nature 414 317 322 10.1038/35104575 10.1038/35104575 11713532 1:CAS:528:DC%2BD3MXovFGis78%3D (Pubitemid 33097809)
    • (2001) Nature , vol.414 , Issue.6861 , pp. 317-322
    • Yang, Z.1    Zhu, Q.2    Luo, K.3    Zhou, Q.4
  • 77
    • 5144225191 scopus 로고    scopus 로고
    • A novel systemically active caspase inhibitor attenuates the toxicities of MPTP, malonate, and 3NP in vivo
    • DOI 10.1016/j.nbd.2004.07.021, PII S096999610400169X
    • L Yang S Sugama RP Mischak M Kiaei N Bizat E Brouillet TH Joh MF Beal 2004 A novel systemically active caspase inhibitor attenuates the toxicities of MPTP, malonate, and 3NP in vivo Neurobiol Dis 17 250 259 10.1016/j.nbd.2004.07. 021 10.1016/j.nbd.2004.07.021 15474362 1:CAS:528:DC%2BD2cXotlSlsbc%3D (Pubitemid 39345780)
    • (2004) Neurobiology of Disease , vol.17 , Issue.2 , pp. 250-259
    • Yang, L.1    Sugama, S.2    Mischak, R.P.3    Kiaei, M.4    Bizat, N.5    Brouillet, E.6    Joh, T.H.7    Beal, M.F.8
  • 79
    • 0034641936 scopus 로고    scopus 로고
    • Apoptosis in the nervous system
    • DOI 10.1038/35037739
    • J Yuan BA Yankner 2000 Apoptosis in the nervous system Nature 407 802 809 10.1038/35037739 10.1038/35037739 11048732 1:CAS:528:DC%2BD3cXnsFWrsbY%3D (Pubitemid 30780744)
    • (2000) Nature , vol.407 , Issue.6805 , pp. 802-809
    • Yuan, J.1    Yankner, B.A.2
  • 80
    • 0029006743 scopus 로고
    • Identification of p53 target genes through immune selection of genomic DNA: The cyclin G gene contains two distinct p53 binding sites
    • 7784084 1:CAS:528:DyaK2MXmsFCgsLc%3D
    • A Zauberman A Lupo M Oren 1995 Identification of p53 target genes through immune selection of genomic DNA: the cyclin G gene contains two distinct p53 binding sites Oncogene 10 2361 2366 7784084 1:CAS:528:DyaK2MXmsFCgsLc%3D
    • (1995) Oncogene , vol.10 , pp. 2361-2366
    • Zauberman, A.1    Lupo, A.2    Oren, M.3
  • 82
    • 39149107803 scopus 로고    scopus 로고
    • Mechanisms and functional implications of adult neurogenesis
    • DOI 10.1016/j.cell.2008.01.033, PII S0092867408001347
    • C Zhao W Deng FH Gage 2008 Mechanisms and functional implications of adult neurogenesis Cell 132 645 660 10.1016/j.cell.2008.01.033 10.1016/j.cell.2008.01.033 18295581 1:CAS:528:DC%2BD1cXivVagtrY%3D (Pubitemid 351253687)
    • (2008) Cell , vol.132 , Issue.4 , pp. 645-660
    • Zhao, C.1    Deng, W.2    Gage, F.H.3
  • 83
    • 0036379174 scopus 로고    scopus 로고
    • A peptide derived from cyclin-dependent kinase activator (p35) specifically inhibits Cdk5 activity and phosphorylation of tau protein in transfected cells
    • 10.1046/j.1432-1033.2002.03133.x 10.1046/j.1432-1033.2002.03133.x 12230554 1:CAS:528:DC%2BD38XptlaqsrY%3D
    • YL Zheng BS Li ND Amin W Albers HC Pant 2002 A peptide derived from cyclin-dependent kinase activator (p35) specifically inhibits Cdk5 activity and phosphorylation of tau protein in transfected cells Eur J Biochem 269 4427 4434 10.1046/j.1432-1033.2002.03133.x 10.1046/j.1432-1033.2002.03133.x 12230554 1:CAS:528:DC%2BD38XptlaqsrY%3D
    • (2002) Eur J Biochem , vol.269 , pp. 4427-4434
    • Zheng, Y.L.1    Li, B.S.2    Amin, N.D.3    Albers, W.4    Pant, H.C.5
  • 84
    • 13244264765 scopus 로고    scopus 로고
    • A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons
    • DOI 10.1038/sj.emboj.7600441
    • YL Zheng S Kesavapany M Gravell RS Hamilton M Schubert N Amin W Albers P Grant HC Pant 2005 A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons EMBO J 24 209 220 10.1038/sj.emboj.7600441 10.1038/sj.emboj.7600441 15592431 1:CAS:528:DC%2BD2MXlvVKmug%3D%3D (Pubitemid 40188478)
    • (2005) EMBO Journal , vol.24 , Issue.1 , pp. 209-220
    • Zheng, Y.-L.1    Kesavapany, S.2    Gravell, M.3    Hamilton, R.S.4    Schubert, M.5    Amin, N.6    Albers, W.7    Grant, P.8    Pant, H.C.9
  • 85
    • 33846828462 scopus 로고    scopus 로고
    • Cdk5 modulation of mitogen-activated protein kinase signaling regulates neuronal survival
    • DOI 10.1091/mbc.E06-09-0851
    • YL Zheng BS Li J Kanungo S Kesavapany N Amin P Grant HC Pant 2007 Cdk5 Modulation of mitogen-activated protein kinase signaling regulates neuronal survival Mol Biol Cell 18 404 413 10.1091/mbc.E06-09-0851 10.1091/mbc.E06-09- 0851 17108320 1:CAS:528:DC%2BD2sXhsFarsLs%3D (Pubitemid 46213211)
    • (2007) Molecular Biology of the Cell , vol.18 , Issue.2 , pp. 404-413
    • Zheng, Y.-L.1    Li, B.-S.2    Kanungo, J.3    Kesavapany, S.4    Amin, N.5    Grant, P.6    Pant, H.C.7
  • 86
    • 33847749886 scopus 로고    scopus 로고
    • Inhibiting cell cycle progression reduces reactive astrogliosis initiated by scratch injury in vitro and by cerebral ischemia in vivo
    • DOI 10.1002/glia.20476
    • Z Zhu Q Zhang Z Yu L Zhang D Tian S Zhu B Bu M Xie W Wang 2007 Inhibiting cell cycle progression reduces reactive astrogliosis initiated by scratch injury in vitro and by cerebral ischemia in vivo Glia 55 546 558 10.1002/glia.20476 10.1002/glia.20476 17243097 (Pubitemid 46383184)
    • (2007) GLIA , vol.55 , Issue.5 , pp. 546-558
    • Zhu, Z.1    Zhang, Q.2    Yu, Z.3    Zhang, L.4    Tian, D.5    Zhu, S.6    Bu, B.7    Xie, M.8    Wang, W.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.