Neurogenesis and neuroprotection induced by peripheral immunomodulatory treatment of experimental autoimmune encephalomyelitis

Journal of Neuroscience

Volumn 25, Issue 36, 2005, Pages 8217-8228

  Aharoni, Rina ^a   Arnon, Ruth ^a   Eilam, Raya ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

EAE; Experimental autoimmune encephalomyelitis; Glatiramer acetate; Immunomodulation; MS; Multiple sclerosis; Neurogenesis; Neuroprotection

Indexed keywords

GLATIRAMER; YELLOW FLUORESCENT PROTEIN;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ARTICLE; BRAIN INJURY; BRAIN REGION; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; IN VIVO STUDY; MULTIPLE SCLEROSIS; NERVOUS SYSTEM DEVELOPMENT; NEUROPROTECTION; NEWBORN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; STEM CELL; TRANSGENIC MOUSE;

ANIMALS; BACTERIAL PROTEINS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; GENES, REPORTER; IMMUNOSUPPRESSIVE AGENTS; LUMINESCENT PROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MYELIN-ASSOCIATED GLYCOPROTEIN; NERVE REGENERATION; PEPTIDES;

EID: 24744435759     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1859-05.2005     Document Type: Article

References (33)

1. Aharoni R, Teitelbaum D, Sela M, Arnon R (1998) Bystander suppression of experimental autoimmune encephalomyelitis by T cell lines and clones of the Th2 type induced by copolymer 1. J Neuroimmunol 2:135-146.
2. Aharoni R, Teitelbaum D, Leitner O, Meshorer A, Sela M, Arnon R (2000) Specific Th2 cells accumulate in the central nervous system of mice protected against experimental autoimmune encephalomyelitis by copolymer 1. Proc Natl Acad Sci USA 97:11472-11477.
3. Aharoni R, Meshorer A, Sela M, Arnon R (2002) Oral treatment of mice with copolymer 1 (glatiramer acetate) results in the accumulation of specific Th2 cells in the central nervous system. J Neuroimmunol 126:58-68.
4. Aharoni R, Kayhan B, Eilam R, Sela M, Arnon R (2003) Glatiramer acetate-specific T cells in the brain express T helper 2/3 cytokines and brain-derived neurotrophic factor in situ. Proc Natl Acad Sci USA 100:14157-14162.
5. Aharoni R, Eilam R, Labunskay G, Sela M, Arnon R (2004) Copaxone (glatiramer acetate) injection augment brain derived neurotrophic factor expression in the brain. Multiple Sclerosis 10:S256.
6. Arlotta P, Magavi SS, Macklis JD (2003) Induction of adult neurogenesis molecular manipulation of neural precursors in situ. Ann NY Acad Sci 991:229-236.
7. Arnon R, Sela M (2003) Immunomodulation by the copolymer glatiramer acetate. J Mol Recognit 16:412-421.
8. Bayer SA, Altman J, Russo RJ, Dai XF, Simmons JA (1991) Cell migration in the embryonic neocortex. I. J Comp Neurol 307:499-516.
9. Behi ME, Dubucquoi S, Lefranc D, Zephir H, De Seze J, Vermersch P, Prin L (2005) New insights into cell responses involved in experimental autoimmune encephalomyelitis and multiple sclerosis. Immunol Lett 96:11-26.
10. Bernier PJ, Bedard A, Vinet J, Levesque M, Parent A (2002) Newly generated neurons in the amygdala and adjoining cortex of adult primates. Proc Natl Acad Sci USA 99:11464-11469.
11. Bjartmar C, Wujek JR, Trapp BD (2003) Axonal loss in the pathology of MS: consequences for understanding the progressive phase of the disease. J Neurol Sci 15:165-171.
12. Brown JP, Couillard-Despres S, Cooper-Kuhn CM, Winkler J, Aigner L, Kuhn HG (2003) Transient expression of doublecortin during adult neurogenesis. J Comp Neurol 467:1-10.
13. Chen J, Magavi SS, Macklis JD (2004) Neurogenesis of corticospinal motor neurons extending spinal projections in adult mice. Proc Natl Acad Sci USA 101:16357-16362.
14. Dhandapani KM, Brann DW (2003) Transforming growth factor-beta: a neuroprotective factor in cerebral ischemia. Cell Biochem Biophys 39:13-22.
15. Duda PW, Schmied MC, Cook SL, Krieger JI, Hafler DA (2000) Glatiramer acetate (Copaxone) induces degenerate Th2-polarized immune responses in patients with multiple sclerosis. J Clin Invest 105:967-976.
16. Feng G, Mellor RH, Bernstein M, Keller-Peak Cynthia, Nguyen QT, Wallace M, Nerbonne JM, Lichtman JW, Sanes JR (2000) Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP. Neuron 28:41-51.
17. Francis F, Koulakoff A, Boucher D, Chafey P, Schaar B, Vinet MC, Friocourt G, McDonnell N, Reiner O, Kahn A, McConnell SK, Berwald-Netter Y, Denoulet P, Chelly J (1999) Doublecortin is a developmentally regulated microtubule-associated protein expressed in migrating and differentiating neurons. Neuron 23:247-256.
18. Gould E, Gross CG (2002) Neurogenesis in adult mammals: some progress and problems. J Neurosci 22:619-623.
19. Hellings N, Raus J, Stinissen P (2002) Insights into the immunopathogenesis of multiple sclerosis. Immunol Res 25:27-51.
20. Hobom M, Storch MK, Weissert R, Maier K, Radhakrishnan A, Kramer B, Bahr M, Diem R (2004) Mechanisms and time course of neuronal degeneration in experimental autoimmune encephalomyelitis. Brain Pathol 14:148-157.
21. Iwai M, Sato K, Omori N, Nagano I, Manabe Y, Shoji M, Abe K (2002) Three steps of neural stem cells development in gerbil dentate gurus after transient ischemia. J Cereb Blood Flow Metab 22:411-419.
22. Jin K, Sun Y, Xie L, Peel A, Mau XO, Batteur S, Greenberg DA (2003) Directed migration of neuronal precursors into the ischemic cerebral cortex and striatum. Mol Cell Neurosci 24:171-189.
23. Kawauchi S, Beites CL, Crocker CE, Wu HH, Bonnin A, Murray R, Calof AL (2004) Molecular signals regulating proliferation of stem and progenitor cells in mouse olfactory epithelium. Dev Neurosci 26:166-180.
24. Ledeboer A, Breve JP, Poole S, Tilders FJ, Van Dam AM (2000) Interleukin-10, interleukin-4, and transforming growth factor-beta differentially regulate lipopolysaccharide-induced production of pro-inflammatory cytokines and nitric oxide in co-cultures of rat astroglial and microglial cells. Glia 30:134-141.
25. Lessmann V, Gottmann K, Maclcangio M (2003) Neurotrophin secretion: current facts and future prospect. Prog Neurobiol 69:341-374.
26. Magavi SS, Leavitt BR, Macklis J (2000) Induction of neurogenesis in the neocortex of adult mice. Nature 405:951-955.
27. Monje ML, Toda H, Palmer TD (2003) Inflammatory blockade restores adult hippocampal neurogenesis. Science 302:1760-1765.
28. Newman MP, Feron F, Mackay-Sim A (2000) Growth factor regulation of neurogenesis in adult olfactory epithelium. Neuroscience 99:343-350.
29. O'Rourke NA, Sullivan DP, Kaznowsky CE, Jacobs AA, McConnell SK (1995) Tangential migration of neurons in the developing cerebral cortex. Development 121:2165-2176.
30. Pencea V, Bingaman KD, Wiegand SJ, Luskin MB (2001) Infusion of brain-derived neurotrophic factor into the lateral ventricle of the adult rat leads to new neurons in the parenchyma of the striatum, septum, thalamus, and hypothalamus. J Neurosci 1:6706-6717.
31. Picard-Riera N, Decker L, Delarasse C, Goude K, Nait-Oumesmar B, Liblau R, Pham-Dinh D, Evercooren (2002) Experimental autoimmune encephalomyelitis mobilized neuronal progenitors from the subventricular zone to undergo oligodendrogenesis in adult mice. Proc Natl Acad Sci USA 99:13211-13216.
32. Picard-Riera N, Nait-Oumesmar B, Baron-Van Evercooren A (2004) Endogenous adult neural stem cells: limits and potential to repair the injured central nervous system. J Neurosci Res 76:223-231.
33. Stollg G, Jander S (1999) The role of microglia and macrophages in the pathophysiology of the CNS. Prog Neurol 58:233-247.