Ionic-Liquid-Mediated Extraction and Separation Processes for Bioactive Compounds: Past, Present, and Future Trends

Chemical Reviews

Volumn 117, Issue 10, 2017, Pages 6984-7052

  Ventura, Sónia P M ^a   E Silva, Francisca A ^a   Quental, Maria V ^a   Mondal, Dibyendu ^a   Freire, Mara G ^a   Coutinho, João A P ^a  

^a UNIVERSITY OF AVEIRO   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROPHOBICITY; IONIC LIQUIDS; LIQUIDS; NUCLEIC ACIDS; SEPARATION; SOLVENT EXTRACTION;

BIOACTIVE COMPOUNDS; HYDROPHOBIC COMPOUNDS; LIQUID-LIQUID EXTRACTION; MODIFIED MATERIALS; SEPARATION PERFORMANCE; SEPARATION PROCESS; SOLID-LIQUID EXTRACTION; SUPPORTED MATERIALS;

EXTRACTION;

AMINO ACID; BIOLOGICAL PRODUCT; DRUG; IONIC LIQUID; LIPID; NUCLEIC ACID; PROTEIN;

CHEMICAL ANALYSIS; CHEMISTRY; FRACTIONATION; LIQUID LIQUID EXTRACTION; PROCEDURES;

AMINO ACIDS; BIOLOGICAL PRODUCTS; CHEMICAL FRACTIONATION; CHEMISTRY TECHNIQUES, ANALYTICAL; IONIC LIQUIDS; LIPIDS; LIQUID-LIQUID EXTRACTION; NUCLEIC ACIDS; PHARMACEUTICAL PREPARATIONS; PROTEINS;

EID: 85017967894     PISSN: 00092665     EISSN: 15206890     Source Type: Journal    
DOI: 10.1021/acs.chemrev.6b00550     Document Type: Review

References (385)

1. Kates, R. W.; Clark, W. C.; Corell, R.; Hall, J. M.; Jaeger, C. C.; Lowe, I.; McCarthy, J. J.; Schellnhuber, H. J.; Bolin, B.; Dickson, N. M. et al. Sustainability Science Science 2001, 292, 641-642 10.2139/ssrn.257359
2. Seddon, K. R. Ionic Liquids for Clean Technology J. Chem. Technol. Biotechnol. 1997, 68, 351-356 10.1002/(SICI)1097-4660(199704)68:4<351::AID-JCTB613>3.0.CO;2-4
3. Naushad, M.; Alothman, Z. A.; Khan, A. B.; Ali, M. Effect of Ionic Liquid on Activity, Stability, and Structure of Enzymes: A Review Int. J. Biol. Macromol. 2012, 51, 555-560 10.1016/j.ijbiomac.2012.06.020
4. Vijayaraghavan, R.; Izgorodin, A.; Ganesh, V.; Surianarayanan, M.; MacFarlane, D. R. Long-Term Structural and Chemical Stability of DNA in Hydrated Ionic Liquids Angew. Chem., Int. Ed. 2010, 49, 1631-1633 10.1002/anie.200906610
5. Swatloski, R. P.; Spear, S. K.; Holbrey, J. D.; Rogers, R. D. Dissolution of Cellose with Ionic Liquids J. Am. Chem. Soc. 2002, 124, 4974-4975 10.1021/ja025790m
6. Fort, D. A.; Remsing, R. C.; Swatloski, R. P.; Moyna, P.; Moyna, G.; Rogers, R. D. Can Ionic Liquids Dissolve Wood? Processing and Analysis of Lignocellulosic Materials with 1-n-butyl-3-methylimidazolium Chloride Green Chem. 2007, 9, 63-69 10.1039/B607614A
7. Freire, M. G.; Claudio, A. F. M.; Araujo, J. M. M.; Coutinho, J. A. P.; Marrucho, I. M.; Lopes, J. N. C.; Rebelo, L. P. N. Aqueous Biphasic Systems: A Boost Brought about by using Ionic Liquids Chem. Soc. Rev. 2012, 41, 4966-4995 10.1039/c2cs35151j
8. Passos, H.; Freire, M. G.; Coutinho, J. A. P. Ionic Liquid Solutions as Extractive Solvents for Value-Added Compounds from Biomass Green Chem. 2014, 16, 4786-4815 10.1039/C4GC00236A
9. Claudio, A. F. M.; Neves, M. C.; Shimizu, K.; Canongia Lopes, J. N.; Freire, M. G.; Coutinho, J. A. P. The Magic of Aqueous Solutions of Ionic Liquids: Ionic Liquids as a Powerful Class of Catanionic Hydrotropes Green Chem. 2015, 17, 3948-3963 10.1039/C5GC00712G
10. Blesic, M.; Marques, M. H.; Plechkova, N. V.; Seddon, K. R.; Rebelo, L. P. N.; Lopes, A. Self-aggregation of Ionic Liquids: Micelle Formation in Aqueous Solution Green Chem. 2007, 9, 481-490 10.1039/b615406a
11. Agrimi, G.; Alexopoulou, E.; Bartzoka, E. D.; Buonerba, A.; Cavani, F.; Christou, M.; Colucci, A.; Couturier, J.-L.; Crestini, C.; Dubois, J.-L. Biorefineries: An Introduction; Walter de Gruyter GmbH & Co KG, 2015.
12. Pinkert, A.; Marsh, K. N.; Pang, S.; Staiger, M. P. Ionic Liquids and their Interaction with Cellulose Chem. Rev. 2009, 109, 6712-6728 10.1021/cr9001947
13. Wang, H.; Gurau, G.; Rogers, R. D. Ionic Liquid Processing of Cellulose Chem. Soc. Rev. 2012, 41, 1519-1537 10.1039/c2cs15311d
14. Zhu, S.; Wu, Y.; Chen, Q.; Yu, Z.; Wang, C.; Jin, S.; Ding, Y.; Wu, G. Dissolution of Cellulose with Ionic Liquids and its Application: A Mini-review Green Chem. 2006, 8, 325-327 10.1039/b601395c
15. Soares, B.; Passos, H.; Freire, C. S. R.; Coutinho, J. A. P.; Silvestre, A. J. D.; Freire, M. G. Ionic Liquids in Chromatographic and Electrophoretic Techniques: Toward Additional Improvements in the Separation of Natural Compounds Green Chem. 2016, 18, 4582-4604 10.1039/C6GC01778A
16. Ho, T. D.; Zhang, C.; Hantao, L. W.; Anderson, J. L. Ionic Liquids in Analytical Chemistry: Fundamentals, Advances, and Perspectives Anal. Chem. 2014, 86, 262-285 10.1021/ac4035554
17. Koel, M. Ionic Liquids in Chemical Analysis Crit. Rev. Anal. Chem. 2005, 35, 177-192 10.1080/10408340500304016
18. Sun, P.; Armstrong, D. W. Ionic Liquids in Analytical Chemistry Anal. Chim. Acta 2010, 661, 1-16 10.1016/j.aca.2009.12.007
19. Pokorný, J. Are Natural Antioxidants Better-and Safer-than Synthetic Antioxidants? Eur. J. Lipid Sci. Technol. 2007, 109, 629-642 10.1002/ejlt.200700064
20. Zhang, L.; Kujawinski, D. M.; Federherr, E.; Schmidt, T. C.; Jochmann, M. A. Caffeine in your Drink: Natural or Synthetic? Anal. Chem. 2012, 84, 2805-2810 10.1021/ac203197d
21. Capello, C.; Fischer, U.; Hungerbuhler, K. What is a Green Solvent? A Comprehensive Framework for the Environmental Assessment of Solvents Green Chem. 2007, 9, 927-934 10.1039/b617536h
22. Tang, B.; Bi, W.; Tian, M.; Row, K. H. Application of Ionic Liquid for Extraction and Separation of Bioactive Compounds from Plants J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2012, 904, 1-21 10.1016/j.jchromb.2012.07.020
23. Pereira, M. M.; Coutinho, J. A. P.; Freire, M. G. In Ionic Liquids in the Biorefinery Concept: Challenges and Perspectives; The Royal Society of Chemistry, 2016.
24. Bogdanov, M. G. In Alternative Solvents for Natural Products Extraction; Chemat, F.; Vian, A. M., Eds.; Springer: Berlin, 2014.
25. Ressmann, A. K.; Bica, K. In Ionic Liquids for Better Separation Processes; Rodríguez, H., Ed.; Springer: Berlin, 2016.
26. Du, F.-Y.; Xiao, X.-H.; Li, G.-K. Application of Ionic Liquids in the Microwave-assisted Extraction of Trans-Resveratrol from Rhizma Polygoni Cuspidati J. Chromatogr. A 2007, 1140, 56-62 10.1016/j.chroma.2006.11.049
27. Bogdanov, M. G.; Svinyarov, I. Ionic Liquid-supported Solid-liquid Extraction of Bioactive Alkaloids. II. Kinetics, Modeling and Mechanism of Glaucine Extraction from Glaucium flavum Cr. (Papaveraceae) Sep. Purif. Technol. 2013, 103, 279-288 10.1016/j.seppur.2012.10.035
28. Bogdanov, M. G.; Svinyarov, I.; Keremedchieva, R.; Sidjimov, A. Ionic Liquid-supported Solid-liquid Extraction of Bioactive Alkaloids. I. New HPLC Method for Quantitative Determination of Glaucine in Glaucium flavum Cr. (Papaveraceae) Sep. Purif. Technol. 2012, 97, 221-227 10.1016/j.seppur.2012.02.001
29. Claudio, A. F. M.; Ferreira, A. M.; Freire, M. G.; Coutinho, J. A. P. Enhanced Extraction of Caffeine from Guarana Seeds using Aqueous Solutions of Ionic Liquids Green Chem. 2013, 15, 2002-2010 10.1039/c3gc40437d
30. Ressmann, A. K.; Zirbs, R.; Pressler, M.; Gaertner, P.; Bica, K. Surface-active Ionic Liquids for Micellar Extraction of Piperine from Black Pepper Z. Naturforsch., B: J. Chem. Sci. 2013, 68, 1129-1137 10.5560/znb.2013-3196
31. Bogdanov, M. G.; Keremedchieva, R.; Svinyarov, I. Ionic Liquid-supported Solid-liquid Extraction of Bioactive alkaloids. III. Ionic Liquid Regeneration and Glaucine Recovery from Ionic Liquid-aqueous Crude Extract of Glaucium flavum Cr. (Papaveraceae) Sep. Purif. Technol. 2015, 155, 13-19 10.1016/j.seppur.2015.02.003
32. Svinyarov, I.; Keremedchieva, R.; Bogdanov, M. G. Ionic Liquid-supported Solid-liquid Extraction of Bioactive Alkaloids. IV. New HPLC Method for Quantitative Determination of Galantamine in Leucojum Aestivum L. (Amaryllidaceae) Sep. Sci. Technol. 2016, 51, 2691-2699 10.1080/01496395.2016.1171783
33. Chowdhury, S. A.; Vijayaraghavan, R.; MacFarlane, D. R. Distillable Ionic Liquid Extraction of Tannins from Plant Materials Green Chem. 2010, 12, 1023-1028 10.1039/b923248f
34. Santos, J. H. P. M.; e Silva, F. A.; Coutinho, J. A. P.; Ventura, S. P. M.; Pessoa, A., Jr Ionic Liquids as a Novel Class of Electrolytes in Polymeric Aqueous Biphasic Systems Process Biochem. 2015, 50, 661-668 10.1016/j.procbio.2015.02.001
35. Ressmann, A. K.; Strassl, K.; Gaertner, P.; Zhao, B.; Greiner, L.; Bica, K. New Aspects for Biomass Processing with Ionic Liquids: Towards the Isolation of Pharmaceutically Active Betulin Green Chem. 2012, 14, 940-944 10.1039/c2gc16389f
36. Ressmann, A. K.; Gaertner, P.; Bica, K. From Plant to Drug: Ionic Liquids for the Reactive Dissolution of Biomass Green Chem. 2011, 13, 1442-1447 10.1039/c1gc15058h
37. Usuki, T.; Yasuda, N.; Yoshizawa-Fujita, M.; Rikukawa, M. Extraction and Isolation of Shikimic Acid from Ginkgo Biloba Leaves Utilizing an Ionic Liquid that Dissolves Cellulose Chem. Commun. 2011, 47, 10560-10562 10.1039/c1cc13306c
38. Jin, W.; Yang, Q.; Huang, B.; Bao, Z.; Su, B.; Ren, Q.; Yang, Y.; Xing, H. Enhanced Solubilization and Extraction of Hydrophobic Bioactive Compounds using Water/Ionic Liquid Mixtures Green Chem. 2016, 18, 3549-3557 10.1039/C6GC00584E
39. Lu, Y.; Ma, W.; Hu, R.; Dai, X.; Pan, Y. Ionic Liquid-based Microwave-assisted Extraction of Phenolic Alkaloids from the Medicinal Plant Nelumbo Nucifera Gaertn J. Chromatogr. A 2008, 1208, 42-46 10.1016/j.chroma.2008.08.070
40. Ma, W.; Lu, Y.; Hu, R.; Chen, J.; Zhang, Z.; Pan, Y. Application of Ionic Liquids based Microwave-assisted Extraction of Three Alkaloids N-nornuciferine, O-nornuciferine, and Nuciferine from Lotus Leaf Talanta 2010, 80, 1292-1297 10.1016/j.talanta.2009.09.027
41. Xu, W.; Chu, K.; Li, H.; Zhang, Y.; Zheng, H.; Chen, R.; Chen, L. Ionic Liquid-based Microwave-assisted Extraction of Flavonoids from Bauhinia championii (Benth.) Benth Molecules 2012, 17, 14323 10.3390/molecules171214323
42. Du, F.-Y.; Xiao, X.-H.; Luo, X.-J.; Li, G.-K. Application of Ionic Liquids in the Microwave-assisted Extraction of Polyphenolic Compounds from Medicinal Plants Talanta 2009, 78, 1177-1184 10.1016/j.talanta.2009.01.040
43. Zeng, H.; Wang, Y.; Kong, J.; Nie, C.; Yuan, Y. Ionic Liquid-based Microwave-assisted Extraction of Rutin from Chinese Medicinal Plants Talanta 2010, 83, 582-590 10.1016/j.talanta.2010.10.006
44. Gu, H.; Chen, F.; Zhang, Q.; Zang, J. Application of Ionic Liquids in Vacuum Microwave-assisted Extraction followed by Macroporous Resin Isolation of Three Flavonoids Rutin, Hyperoside and Hesperidin from Sorbus Tianschanica Leaves J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2016, 1014, 45-55 10.1016/j.jchromb.2016.01.045
45. Zhou, Y.; Wu, D.; Cai, P.; Cheng, G.; Huang, C.; Pan, Y. Special Effect of Ionic Liquids on the Extraction of Flavonoid Glycosides from Chrysanthemum Morifolium Ramat by Microwave Assistance Molecules 2015, 20, 7683 10.3390/molecules20057683
46. Zhang, Q.; Zhao, S.-h.; Chen, J.; Zhang, L.-w. Application of Ionic Liquid-based Microwave-assisted Extraction of Flavonoids from Scutellaria Baicalensis Georgi J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2015, 1002, 411-417 10.1016/j.jchromb.2015.08.021
47. Liu, T.; Sui, X.; Zhang, R.; Yang, L.; Zu, Y.; Zhang, L.; Zhang, Y.; Zhang, Z. Application of Ionic Liquids based Microwave-assisted Simultaneous Extraction of Carnosic Acid, Rosmarinic Acid and Essential Oil from Rosmarinus Officinalis J. Chromatogr. A 2011, 1218, 8480-8489 10.1016/j.chroma.2011.09.073
48. Yansheng, C.; Zhida, Z.; Changping, L.; Qingshan, L.; Peifang, Y.; Welz-Biermann, U. Microwave-assisted Extraction of Lactones from Ligusticum Chuanxiong Hort. Using Protic Ionic Liquids Green Chem. 2011, 13, 666-670 10.1039/c0gc00864h
49. Ma, C.-H.; Liu, T.-T.; Yang, L.; Zu, Y.-G.; Wang, S.-Y.; Zhang, R.-R. Study on Ionic Liquid-based Ultrasonic-assisted Extraction of Biphenyl Cyclooctene lignans from the Fruit of Schisandra Chinensis Baill Anal. Chim. Acta 2011, 689, 110-116 10.1016/j.aca.2011.01.012
50. Ma, C.-H.; Liu, T.-T.; Yang, L.; Zu, Y.-g.; Chen, X.; Zhang, L.; Zhang, Y.; Zhao, C. Ionic Liquid-based Microwave-assisted Extraction of Essential Oil and Biphenyl Cyclooctene Lignans from Schisandra Chinensis Baill Fruits J. Chromatogr. A 2011, 1218, 8573-8580 10.1016/j.chroma.2011.09.075
51. Zirbs, R.; Strassl, K.; Gaertner, P.; Schroder, C.; Bica, K. Exploring Ionic Liquid-biomass Interactions: Towards the Improved Isolation of Shikimic Acid from Star Anise Pods RSC Adv. 2013, 3, 26010-26016 10.1039/c3ra45572f
52. Akinlua, A.; Jochmann, M. A.; Schmidt, T. C. Ionic Liquid as Green Solvent for Leaching of Polycyclic Aromatic Hydrocarbons from Petroleum Source Rock Ind. Eng. Chem. Res. 2015, 54, 12960-12965 10.1021/acs.iecr.5b03367
53. Cao, X.; Ye, X.; Lu, Y.; Yu, Y.; Mo, W. Ionic Liquid-based Ultrasonic-assisted Extraction of Piperine from White Pepper Anal. Chim. Acta 2009, 640, 47-51 10.1016/j.aca.2009.03.029
54. Ma, C.-h.; Wang, S.-y.; Yang, L.; Zu, Y.-g.; Yang, F.-j.; Zhao, C.-j.; Zhang, L.; Zhang, Z.-h. Ionic Liquid-aqueous Solution Ultrasonic-assisted extraction of Camptothecin and 10-hydroxycamptothecin from Camptotheca Acuminata Samara Chem. Eng. Process. 2012, 57-58, 59-64 10.1016/j.cep.2012.03.008
55. Yang, L.; Wang, H.; Zu, Y.-g.; Zhao, C.; Zhang, L.; Chen, X.; Zhang, Z. Ultrasound-assisted Extraction of the Three Terpenoid Indole Alkaloids Vindoline, Catharanthine and Vinblastine from Catharanthus Roseus using Ionic Liquid Aqueous Solutions Chem. Eng. J. 2011, 172, 705-712 10.1016/j.cej.2011.06.039
56. Zhang, L.; Geng, Y.; Duan, W.; Wang, D.; Fu, M.; Wang, X. Ionic Liquid-based Ultrasound-assisted Extraction of Fangchinoline and Tetrandrine from Stephaniae Tetrandrae J. Sep. Sci. 2009, 32, 3550-3554 10.1002/jssc.200900413
57. Wang, W.; Li, Q.; Liu, Y.; Chen, B. Ionic Liquid-aqueous Solution Ultrasonic-assisted Extraction of Three kinds of Alkaloids from Phellodendron Amurense Rupr and Optimize Conditions use Response Surface Ultrason. Sonochem. 2015, 24, 13-18 10.1016/j.ultsonch.2014.10.009
58. Sun, Y.; Li, W.; Wang, J. Ionic Liquid Based Ultrasonic Assisted Extraction of Isoflavones from Iris Tectorum Maxim and Subsequently Separation and Purification by High-speed Counter-current Chromatography J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2011, 879, 975-980 10.1016/j.jchromb.2011.03.010
59. Chen, F.; Hou, K.; Li, S.; Zu, Y.; Yang, L. Extraction and Chromatographic Determination of Shikimic Acid in Chinese Conifer Needles with 1-benzyl-3-methylimidazolium Bromide Ionic Liquid Aqueous Solutions J. Anal. Methods Chem. 2014, 2014, 1-12 10.1155/2014/256473
60. Tan, T.; Lai, C.-J.-S.; OuYang, H.; He, M.-Z.; Feng, Y. Ionic Liquid-based Ultrasound-assisted Extraction and Aqueous Two-phase System for Analysis of Caffeoylquinic Acids from Flos Lonicerae Japonicae J. Pharm. Biomed. Anal. 2016, 120, 134-141 10.1016/j.jpba.2015.12.019
61. Wang, X.-H.; Cai, C.; Li, X.-M. Optimal Extraction of Gallic Acid from Suaeda Glauca Bge. Leaves and Enhanced Efficiency by Ionic Liquids Int. J. Chem. Eng. 2016, 2016, 1-9 10.1155/2016/5217802
62. Lin, H.; Zhang, Y.; Han, M.; Yang, L. Aqueous Ionic Liquid Based Ultrasonic Assisted Extraction of Eight Ginsenosides from Ginseng Root Ultrason. Sonochem. 2013, 20, 680-684 10.1016/j.ultsonch.2012.10.003
63. Wu, K.; Zhang, Q.; Liu, Q.; Tang, F.; Long, Y.; Yao, S. Ionic Liquid Surfactant-mediated Ultrasonic-assisted Extraction Coupled to HPLC: Application to Analysis of Tanshinones in Salvia Miltiorrhiza Bunge J. Sep. Sci. 2009, 32, 4220-4226 10.1002/jssc.200900398
64. Harde, S. M.; Lonkar, S. L.; Degani, M. S.; Singhal, R. S. Ionic Liquid Based Ultrasonic-assisted Extraction of Forskolin from Coleus Forskohlii Roots Ind. Crops Prod. 2014, 61, 258-264 10.1016/j.indcrop.2014.07.016
65. Yang, L.; Liu, Y.; Zu, Y.-G.; Zhao, C.-J.; Zhang, L.; Chen, X.-Q.; Zhang, Z.-H. Optimize the Process of Ionic Liquid-based Ultrasonic-assisted Extraction of Aesculin and Aesculetin from Cortex Fraxini by Response Surface Methodology Chem. Eng. J. 2011, 175, 539-547 10.1016/j.cej.2011.09.110
66. Lu, H.-T.; Jiang, Y.; Chen, F. Preparative High-speed Counter-current Chromatography for Purification of Shikonin from the Chinese Medicinal Plant Lithospermum Erythrorhizon J. Chromatogr. A 2004, 1023, 159-163 10.1016/j.chroma.2003.09.022
67. Xiao, Y.; Wang, Y.; Gao, S.; Zhang, R.; Ren, R.; Li, N.; Zhang, H. Determination of the Active Constituents in Arnebia Euchroma (Royle) Johnst. by Ionic Liquid-based Ultrasonic-assisted Extraction High-performance Liquid Chromatography J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2011, 879, 1833-1838 10.1016/j.jchromb.2011.05.009
68. Lu, C.; Wang, H.; Lv, W.; Ma, C.; Lou, Z.; Xie, J.; Liu, B. Ionic Liquid-based Ultrasonic/microwave-assisted Extraction Combined with UPLC-MS-MS for the Determination of Tannins in Galla Chinensis Nat. Prod. Res. 2012, 26, 1842-1847 10.1080/14786419.2011.607454
69. Lu, C.; Wang, H.; Lv, W.; Ma, C.; Xu, P.; Zhu, J.; Xie, J.; liu, B.; Zhou, Q. Ionic Liquid-based Ultrasonic/Microwave-assisted Extraction combined with UPLC for the Determination of Anthraquinones in Rhubarb Chromatographia 2011, 74, 139-144 10.1007/s10337-011-2023-5
70. Liu, F.; Wang, D.; Liu, W.; Wang, X.; Bai, A.; Huang, L. Ionic Liquid-based Ultrahigh Pressure Extraction of Five Tanshinones from Salvia Miltiorrhiza Bunge Sep. Purif. Technol. 2013, 110, 86-92 10.1016/j.seppur.2013.03.012
71. Dong, L. L.; Fu, Y. J.; Zu, Y. G.; Li, J.; Li, X. J.; Efferth, T. Negative Pressure Cavitation Accelerated Processing for Extraction of Main Bioactive Flavonoids from Radix Scutellariae Chem. Eng. Process. 2011, 50, 780-789 10.1016/j.cep.2011.05.014
72. Duan, M.-H.; Luo, M.; Zhao, C.-J.; Wang, W.; Zu, Y.-G.; Zhang, D.-Y.; Yao, X.-h.; Fu, Y.-J. Ionic Liquid-based Negative Pressure Cavitation-assisted Extraction of Three Main Flavonoids from the Pigeonpea Roots and its Pilot-scale Application Sep. Purif. Technol. 2013, 107, 26-36 10.1016/j.seppur.2013.01.003
73. Wang, Z.; Hu, J.; Du, H.; He, S.; Li, Q.; Zhang, H. Microwave-assisted Ionic Liquid Homogeneous Liquid-liquid Microextraction Coupled with High Performance Liquid Chromatography for the Determination of Anthraquinones in Rheum palmatum L J. Pharm. Biomed. Anal. 2016, 125, 178-185 10.1016/j.jpba.2016.03.046
74. Extraction of Artemisinin using Ionic Liquids; Project Report 003-001/1; Bioniqus Ltd: York, U.K., 2006.
75. Extraction of Artemisinin using Ionic Liquids; Project Report 003-003/3; Bioniqus Ltd: York, U.K., 2008.
76. Bi, W.; Tian, M.; Row, K. H. Ultrasonication-assisted Extraction and Preconcentration of Medicinal Products from Herb by Ionic Liquids Talanta 2011, 85, 701-706 10.1016/j.talanta.2011.04.054
77. De Clercq, E. Antiviral Agents Active Against Influenza A Viruses Nat. Rev. Drug Discovery 2006, 5, 1015-1025 10.1038/nrd2175
78. Nagao, T.; Komine, Y.; Soga, S.; Meguro, S.; Hase, T.; Tanaka, Y.; Tokimitsu, I. Ingestion of a Tea Rich in Catechins Leads to a Reduction in Body Fat and Malondialdehyde-Modified LDL in Men Am. J. Clin. Nutr. 2005, 81, 122-129
79. Ribeiro, B. D.; Coelho, M. A. Z.; Rebelo, L. P. N.; Marrucho, I. M. Ionic Liquids as Additives for Extraction of Saponins and Polyphenols from Mate (Ilex paraguariensis) and Tea (Camellia sinensis) Ind. Eng. Chem. Res. 2013, 52, 12146-12153 10.1021/ie400529h
80. Freire, M. G.; Neves, C. M. S. S.; Marrucho, I. M.; Coutinho, J. A. P.; Fernandes, A. M. Hydrolysis of Tetrafluoroborate and Hexafluorophosphate Counter Ions in Imidazolium-based Ionic Liquids J. Phys. Chem. A 2010, 114, 3744-3749 10.1021/jp903292n
81. Absalan, G.; Akhond, M.; Sheikhian, L. Extraction and High Performance Liquid Chromatographic Determination of 3-indole Butyric Acid in Pea Plants by using Imidazolium-based Ionic Liquids as Extractant Talanta 2008, 77, 407-411 10.1016/j.talanta.2008.06.049
82. Tan, Z.; Li, F.; Xu, X. Isolation and Purification of Aloe Anthraquinones based on an Ionic Liquid/Salt Aqueous Two-phase System Sep. Purif. Technol. 2012, 98, 150-157 10.1016/j.seppur.2012.06.021
83. Santos, J.; Martins, M.; Silvestre, A. J. D.; Coutinho, J. A. P.; Ventura, S. P. M. Fractionation of Phenolic Compounds from Lignin Depolymerisation using Polymeric Aqueous Biphasic Systems with Ionic Surfactants as Electrolytes Green Chem. 2016, 18, 5569-5579 10.1039/C6GC01440B
84. Freire, M. G.; Louros, C. L. S.; Rebelo, L. P. N.; Coutinho, J. A. P. Aqueous Biphasic Systems Composed of a Water-stable Ionic Liquid + Carbohydrates and their Applications Green Chem. 2011, 13, 1536-1545 10.1039/c1gc15110j
85. Domínguez-Pérez, M.; Tomé, L. I. N.; Freire, M. G.; Marrucho, I. M.; Cabeza, O.; Coutinho, J. A. P. (Extraction of Biomolecules using) Aqueous Biphasic Systems formed by Ionic Liquids and Aminoacids Sep. Purif. Technol. 2010, 72, 85-91 10.1016/j.seppur.2010.01.008
86. Freire, M. G.; Teles, A. R. R.; Canongia Lopes, J. N.; Rebelo, L. P. N.; Marrucho, I. M.; Coutinho, J. A. P. Partition Coefficients of Alkaloids in Biphasic Ionic-Liquid-Aqueous Systems and their Dependence on the Hofmeister Series Sep. Sci. Technol. 2012, 47, 284-291 10.1080/01496395.2011.620585
87. Freire, M. G.; Neves, C. M. S. S.; Marrucho, I. M.; Canongia Lopes, J. N.; Rebelo, L. P. N.; Coutinho, J. A. P. High-performance Extraction of Alkaloids using Aqueous Two-phase Systems with Ionic Liquids Green Chem. 2010, 12, 1715-1718 10.1039/c0gc00179a
88. Santos, P. L.; Santos, L. N. S.; Ventura, S. P. M.; de Souza, R. L.; Coutinho, J. A. P.; Soares, C. M. F.; Lima, A. S. Recovery of Capsaicin from Capsicum frutescens by Applying Aqueous Two-phase Systems based on Acetonitrile and Cholinium-based Ionic Liquids Chem. Eng. Res. Des. 2016, 112, 103-112 10.1016/j.cherd.2016.02.031
89. Li, S.; He, C.; Liu, H.; Li, K.; Liu, F. Ionic Liquid-based Aqueous two-phase System, A Sample Pretreatment Procedure prior to High-performance Liquid Chromatography of Opium Alkaloids J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2005, 826, 58-62 10.1016/j.jchromb.2005.08.005
90. Santos, J. H.; e Silva, F. A.; Ventura, S. P. M.; Coutinho, J. A. P.; de Souza, R. L.; Soares, C. M. F.; Lima, A. S. Ionic Liquid-based Aqueous Biphasic Systems as a Versatile Tool for the Recovery of Antioxidant Compounds Biotechnol. Prog. 2015, 31, 70-77 10.1002/btpr.2000
91. Wang, R.; Chang, Y.; Tan, Z.; Li, F. Applications of Choline amino Acid Ionic Liquid in Extraction and Separation of Flavonoids and Pectin from Ponkan Peels Sep. Sci. Technol. 2016, 51, 1093-1102 10.1080/01496395.2016.1143006
92. Cláudio, A. F. M.; Ferreira, A. M.; Freire, C. S. R.; Silvestre, A. J. D.; Freire, M. G.; Coutinho, J. A. P. Optimization of the Gallic Acid Extraction using Ionic-liquid-based Aqueous Two-phase Systems Sep. Purif. Technol. 2012, 97, 142-149 10.1016/j.seppur.2012.02.036
93. Claudio, A. F. M.; Marques, C. F. C.; Boal-Palheiros, I.; Freire, M. G.; Coutinho, J. A. P. Development of Back-extraction and Recyclability Routes for Ionic-liquid-based Aqueous Two-phase Systems Green Chem. 2014, 16, 259-268 10.1039/C3GC41999A
94. Almeida, M. R.; Passos, H.; Pereira, M. M.; Lima, á. S.; Coutinho, J. A. P.; Freire, M. G. Ionic Liquids as Additives to Enhance the Extraction of Antioxidants in Aqueous Two-phase Systems Sep. Purif. Technol. 2014, 128, 1-10 10.1016/j.seppur.2014.03.004
95. Keremedchieva, R.; Svinyarov, I.; Bogdanov, M. Ionic Liquid-based Aqueous Biphasic Systems-A Facile Approach for Ionic Liquid Regeneration from Crude Plant Extracts Processes 2015, 3, 769 10.3390/pr3040769
96. Smirnova, S. V.; Torocheshnikova, I. I.; Formanovsky, A. A.; Pletnev, I. V. Solvent Extraction of Amino Acids into a Room Temperature Ionic Liquid with Dicyclohexano-18-Crown-6 Anal. Bioanal. Chem. 2004, 378, 1369-1375 10.1007/s00216-003-2398-8
97. Fan, Y.; Chen, M.; Shentu, C.; El-Sepai, F.; Wang, K.; Zhu, Y.; Ye, M. Ionic Liquids Extraction of Para Red and Sudan Dyes from Chilli Powder, Chilli Oil and Food Additive Combined with High Performance Liquid Chromatography Anal. Chim. Acta 2009, 650, 65-69 10.1016/j.aca.2009.03.025
98. Das, A. K.; Prasad, K. Extraction of Plant Growth Regulators Present in Kappaphycus Alvarezii Sap using Imidazolium Based Ionic Liquids: Detection and Quantification by using HPLC-DAD Technique Anal. Methods 2015, 7, 9064-9067 10.1039/C5AY02210J
99. Larriba, M.; Omar, S.; Navarro, P.; Garcia, J.; Rodriguez, F.; Gonzalez-Miquel, M. Recovery of Tyrosol from Aqueous Streams using Hydrophobic Ionic Liquids: A First Step Towards Developing Sustainable Processes for Olive Mill Wastewater (OMW) Management RSC Adv. 2016, 6, 18751-18762 10.1039/C5RA26510J
100. Cláudio, A. F. M.; Freire, M. G.; Freire, C. S. R.; Silvestre, A. J. D.; Coutinho, J. A. P. Extraction of Vanillin using Ionic-liquid-based Aqueous Two-phase Systems Sep. Purif. Technol. 2010, 75, 39-47 10.1016/j.seppur.2010.07.007
101. Albertsson, P. Partition of Cell Particles and Macromolecules: Separation and Purification of Biomolecules, Cell Organelles, Membranes, and Cells in Aqueous Polymer Two-phase Systems and Their Use in Biochemical Analysis and Biotechnology, 3 rd ed.; John Wiley and Sons: Chichester, 1987.
102. Gutowski, K. E.; Broker, G. A.; Willauer, H. D.; Huddleston, J. G.; Swatloski, R. P.; Holbrey, J. D.; Rogers, R. D. Controlling the Aqueous Miscibility of Ionic Liquids: Aqueous Biphasic Systems of Water-miscible Ionic Liquids and Water-structuring Salts for Recycle, Metathesis, and Separations J. Am. Chem. Soc. 2003, 125, 6632-6633 10.1021/ja0351802
103. Passos, H.; Trindade, M. P.; Vaz, T. S. M.; da Costa, L. P.; Freire, M. G.; Coutinho, J. A. P. The Impact of Self-aggregation on the Extraction of Biomolecules in Ionic-liquid-based Aqueous Two-phase Systems Sep. Purif. Technol. 2013, 108, 174-180 10.1016/j.seppur.2013.02.008
104. 4 Aqueous Biphasic Systems Int. J. Mol. Sci. 2010, 11, 1777 10.3390/ijms11041777
105. Fan, J.-P.; Cao, J.; Zhang, X.-H.; Huang, J.-Z.; Kong, T.; Tong, S.; Tian, Z.-Y.; Zhu, J.-H.; Ouyang, X.-K. Extraction of Puerarin using Ionic Liquid Based Aqueous Two-phase Systems Sep. Sci. Technol. 2012, 47, 1740-1747 10.1080/01496395.2012.659787
106. Yang, Z.; Tan, Z.; Li, F.; Li, X. An Effective Method for the Extraction and Purification of Chlorogenic Acid from Ramie (Boehmeria nivea L.) Leaves using Acidic Ionic Liquids Ind. Crops Prod. 2016, 89, 78-86 10.1016/j.indcrop.2016.05.006
107. Tan, Z.; Yi, Y.; Wang, H.; Zhou, W.; Wang, C. Extraction, Preconcentration and Isolation of Flavonoids from Apocynum venetum L. Leaves using Ionic Liquid-based Ultrasonic-assisted Extraction Coupled with an Aqueous Biphasic System Molecules 2016, 21, 262 10.3390/molecules21030262
108. Ventura, S. P. M.; e Silva, F. A.; Gonçalves, A. M. M.; Pereira, J. L.; Gonçalves, F.; Coutinho, J. A. P. Ecotoxicity Analysis of Cholinium-based Ionic Liquids to Vibrio fischeri Marine Bacteria Ecotoxicol. Environ. Saf. 2014, 102, 48-54 10.1016/j.ecoenv.2014.01.003
109. Petkovic, M.; Ferguson, J. L.; Gunaratne, H. Q. N.; Ferreira, R.; Leitao, M. C.; Seddon, K. R.; Rebelo, L. P. N.; Pereira, C. S. Novel Biocompatible Cholinium-based Ionic Liquids-toxicity and Biodegradability Green Chem. 2010, 12, 643-649 10.1039/b922247b
110. Taha, M.; e Silva, F. A.; Quental, M. V.; Ventura, S. P. M.; Freire, M. G.; Coutinho, J. A. P. Good's Buffers as a Basis for Developing Self-buffering and Biocompatible Ionic Liquids for Biological Research Green Chem. 2014, 16, 3149-3159 10.1039/c4gc00328d
111. Tao, D.-J.; Cheng, Z.; Chen, F.-F.; Li, Z.-M.; Hu, N.; Chen, X.-S. Synthesis and Thermophysical Properties of Biocompatible Cholinium-based Amino Acid Ionic Liquids J. Chem. Eng. Data 2013, 58, 1542-1548 10.1021/je301103d
112. Ventura, S. P. M.; de Barros, R. L. F.; de Pinho Barbosa, J. M.; Soares, C. M. F.; Lima, A. S.; Coutinho, J. A. P. Production and Purification of an Extracellular Lipolytic Enzyme using Ionic Liquid-based Aqueous Two-phase Systems Green Chem. 2012, 14, 734-740 10.1039/c2gc16428k
113. Souza, R. L.; Ventura, S. P. M.; Soares, C. M. F.; Coutinho, J. A. P.; Lima, A. S. Lipase Purification using Ionic Liquids as Adjuvants in Aqueous Two-phase Systems Green Chem. 2015, 17, 3026-3034 10.1039/C5GC00262A
114. Tian, M.; Yan, H.; Row, K. H. Solid-phase Extraction of Tanshinones from Salvia Miltiorrhiza Bunge using Ionic Liquid-modified Silica Sorbents J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2009, 877, 738-742 10.1016/j.jchromb.2009.02.012
115. Luo, H.-W.; Wu, B.-J.; Wu, M.-Y.; Yong, Z.-G.; Niwa, M.; Hirata, Y. Pigments from Salvia Miltiorrhiza Phytochemistry 1985, 24, 815-817 10.1016/S0031-9422(00)84900-6
116. Tian, M.; Row, K. H. SPE of Tanshinones from Salvia miltiorrhiza Bunge by using Imprinted Functionalized Ionic Liquid-modified Silica Chromatographia 2011, 73, 25-31 10.1007/s10337-010-1836-y
117. Tian, M.; Bi, W.; Row, K. H. Solid-phase Extraction of Liquiritin and Glycyrrhizic Acid from Licorice using Ionic Liquid-based Silica Sorbent J. Sep. Sci. 2009, 32, 4033-4039 10.1002/jssc.200900497
118. Bi, W.; Zhou, J.; Row, K. H. Solid Phase Extraction of Three Phenolic Acids from Saliconia Herbacea L. by Different Ionic Liquid-based Silicas J. Liq. Chromatogr. Relat. Technol. 2012, 35, 723-736 10.1080/10826076.2011.608230
119. Bi, W.; Tian, M.; Row, K. H. Selective Extraction and Separation of Oxymatrine from Sophora Flavescens Ait. Extract by Silica-confined Ionic Liquid J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2012, 880, 108-113 10.1016/j.jchromb.2011.11.025
120. Nie, L.-r.; Lu, J.; Zhang, W.; He, A.; Yao, S. Ionic Liquid-modified Silica Gel as Adsorbents for Adsorption and Separation of Water-soluble Phenolic Acids from Salvia militiorrhiza Bunge Sep. Purif. Technol. 2015, 155, 2-12 10.1016/j.seppur.2015.01.037
121. Bi, W.; Tian, M.; Row, K. H. Solid-phase Extraction of Matrine and Oxymatrine from Sophora Flavescens Ait using Amino-imidazolium Polymer J. Sep. Sci. 2010, 33, 1739-1745 10.1002/jssc.200900835
122. Tian, M.; Yan, H.; Row, K. H. Solid-phase Extraction of Caffeine and Theophylline from Green Tea by a New Ionic Liquid-modified Functional Polymer Sorbent Anal. Lett. 2009, 43, 110-118 10.1080/00032710903276554
123. Bi, W.; Tian, M.; Row, K. H. Separation of Phenolic Acids from Natural Plant Extracts using Molecularly Imprinted Anion-exchange Polymer Confined Ionic Liquids J. Chromatogr. A 2012, 1232, 37-42 10.1016/j.chroma.2011.08.054
124. Bi, W.; Tian, M.; Row, K. H. Solid-phase Extraction of Liquiritin and Glycyrrhizin from Licorice using Porous Alkyl-pyridinium Polymer Sorbent Phytochem. Anal. 2010, 21, 496-501 10.1002/pca.1227
125. Wan, X.; Tian, M.; Row, K. H. Ionic Liquid-modified Silica as a New Stationary Phase for Chromatographic Separation J. Anal. Chem. 2010, 65, 798-802 10.1134/S1061934810080058
126. Tian, M.; Bi, W.; Row, K. H. Molecular Imprinting in Ionic Liquid-modified Porous Polymer for Recognitive Separation of Three Tanshinones from Salvia miltiorrhiza Bunge Anal. Bioanal. Chem. 2011, 399, 2495-2502 10.1007/s00216-010-4641-4
127. Zhou, J.; Bi, W.; Row, K. H. Optimization and Development of a SPE-HPLC-UV Method to Determine Astaxanthin in Saccharina japonica J. Food Sci. 2011, 76, C441-C446 10.1111/j.1750-3841.2011.02076.x
128. Bucar, F.; Wube, A.; Schmid, M. Natural Product Isolation-How to get from Biological Material to Pure Compounds Nat. Prod. Rep. 2013, 30, 525-545 10.1039/c3np20106f
129. Lu, Y.; Yu, G.; Wang, W.-J.; Ren, Q.; Li, B.-G.; Zhu, S. Design and Synthesis of Thermoresponsive Ionic Liquid Polymer in Acetonitrile as a Reusable Extractant for Separation of Tocopherol Homologues Macromolecules 2015, 48, 915-924 10.1021/ma502611s
130. Nelson, D. L.; Lehninger, A. L.; Cox, M. M. Lehninger Principles of Biochemistry; W. H. Freeman, 2008.
131. Global Oils and Fats Market 2015-2019, http://www.researchandmarkets.com/research/kk5dw5/global-oils-and (accessed on March, 15 2016).
132. Cooney, M. J.; Benjamin, K. In Ionic Liquids in Lipid Processing and Analysis; AOCS Press, 2016.
133. Pfaltzgraff, L. A.; De bruyn, M.; Cooper, E. C.; Budarin, V.; Clark, J. H. Food Waste Biomass: A Resource for High-value Chemicals Green Chem. 2013, 15, 307-314 10.1039/c2gc36978h
134. Xu, X.; Guo, Z.; Cheong, L.-Z. In Ionic Liquids in Lipid Processing and Analysis; AOCS Press, 2016.
135. Li, M.; Li, T. Enrichment of Omega-3 Polyunsaturated Fatty Acid Methyl Esters by Ionic Liquids Containing Silver Salts Sep. Sci. Technol. 2008, 43, 2072-2089 10.1080/01496390802064174
136. Li, M.; Pittman, C. U., Jr.; Li, T. Extraction of Polyunsaturated Fatty Acid Methyl Esters by Imidazolium-based Ionic Liquids Containing Silver Tetrafluoroborate-Extraction Equilibrium Studies Talanta 2009, 78, 1364-1370 10.1016/j.talanta.2009.02.011
137. Li, M.; Pham, P. J.; Wang, T.; Pittman, C. U., Jr; Li, T. Selective Extraction and Enrichment of Polyunsaturated Fatty Acid Methyl Esters from Fish Oil by Novel π-Complexing Sorbents Sep. Purif. Technol. 2009, 66, 1-8 10.1016/j.seppur.2008.12.009
138. Li, M.; Pham, P. J.; Pittman, C. U., Jr; Li, T. SBA-15-supported Ionic Liquid Compounds Containing Silver Salts: Novel Mesoporous π-complexing Sorbents for Separating Polyunsaturated Fatty Acid Methyl Esters Microporous Mesoporous Mater. 2009, 117, 436-443 10.1016/j.micromeso.2008.07.017
139. Cheong, L.-Z.; Guo, Z.; Yang, Z.; Chua, S.-C.; Xu, X. Extraction and Enrichment of n-3 Polyunsaturated Fatty Acids and Ethyl Esters through Reversible π-π Complexation with Aromatic Rings Containing Ionic Liquids J. Agric. Food Chem. 2011, 59, 8961-8967 10.1021/jf202043w
140. Lateef, H.; Grimes, S.; Kewcharoenwong, P.; Bailey, E. Ionic Liquids in the Selective Recovery of Fat from Composite Foodstuffs J. Chem. Technol. Biotechnol. 2009, 84, 1681-1687 10.1002/jctb.2230
141. Bollin, P. M.; Viamajala, S. Reactive Extraction of Triglycerides as Fatty Acid Methyl Esters using Lewis Acidic Chloroaluminate Ionic Liquids Energy Fuels 2012, 26, 6411-6418 10.1021/ef301101d
142. Olkiewicz, M.; Plechkova, N. V.; Fabregat, A.; Stüber, F.; Fortuny, A.; Font, J.; Bengoa, C. Efficient Extraction of Lipids from Primary Sewage Sludge using Ionic Liquids for Biodiesel Production Sep. Purif. Technol. 2015, 153, 118-125 10.1016/j.seppur.2015.08.038
143. Teixeira, R. E. Energy-efficient Extraction of Fuel and Chemical Feedstocks from Algae Green Chem. 2012, 14, 419-427 10.1039/c2gc16225c
144. Fujita, K.; Kobayashi, D.; Nakamura, N.; Ohno, H. Direct Dissolution of Wet and Saliferous Marine Microalgae by Polar Ionic Liquids without Heating Enzyme Microb. Technol. 2013, 52, 199-202 10.1016/j.enzmictec.2012.12.004
145. Yu, X.; Yang, J.; Lu, H.; Tu, S.-T.; Yan, J. Energy-efficient Extraction of Fuel from Chlorella Vulgaris by Ionic Liquid Combined with CO2 Capture Appl. Energy 2015, 160, 648-655 10.1016/j.apenergy.2015.04.074
146. Kilulya, K. F.; Msagati, T. A. M.; Mamba, B. B. Ionic Liquid-Based Extraction of Fatty Acids from Blue-Green Algal Cells Enhanced by Direct Transesterification and Determination using GC × GC-TOFMS Chromatographia 2014, 77, 479-486 10.1007/s10337-014-2632-x
147. Young, G.; Nippgen, F.; Titterbrandt, S.; Cooney, M. J. Lipid Extraction from Biomass using Co-solvent Mixtures of Ionic Liquids and Polar Covalent Molecules Sep. Purif. Technol. 2010, 72, 118-121 10.1016/j.seppur.2010.01.009
148. Severa, G.; Kumar, G.; Cooney, M. J. Corecovery of Bio-Oil and Fermentable Sugars from Oil-Bearing Biomass Int. J. Chem. Eng. 2013, 2013, 1-10 10.1155/2013/617274
149. Severa, G.; Kumar, G.; Troung, M.; Young, G.; Cooney, M. J. Simultaneous Extraction and Separation of Phorbol Esters and Bio-oil from Jatropha Biomass using Ionic Liquid-methanol co-solvents Sep. Purif. Technol. 2013, 116, 265-270 10.1016/j.seppur.2013.06.001
150. Severa, G.; Kumar, G.; Cooney, M. J. Corecovery of Lipids and Fermentable Sugars from Rhodosporidium Toruloides using Ionic Liquid Cosolvents: Application of Recycle to Batch Fermentation Biotechnol. Prog. 2014, 30, 1239-1242 10.1002/btpr.1952
151. Kim, Y.-H.; Choi, Y.-K.; Park, J.; Lee, S.; Yang, Y.-H.; Kim, H. J.; Park, T.-J.; Hwan Kim, Y.; Lee, S. H. Ionic Liquid-mediated Extraction of Lipids from Algal Biomass Bioresour. Technol. 2012, 109, 312-315 10.1016/j.biortech.2011.04.064
152. Chen, X.; Hu, L.; Xing, R.; Liu, S.; Yu, H.; Qin, Y.; Li, K.; Li, R.; Li, P. Ionic Liquid-assisted Subcritical Water Promotes the Extraction of Lipids from Wet Microalgae Scenedesmus sp Eur. J. Lipid Sci. Technol. 2015, 117, 1192-1198 10.1002/ejlt.201400189
153. Olkiewicz, M.; Caporgno, M. P.; Font, J.; Legrand, J.; Lepine, O.; Plechkova, N. V.; Pruvost, J.; Seddon, K. R.; Bengoa, C. A Novel Recovery Process for Lipids from Microalgae for Biodiesel Production using a Hydrated Phosphonium Ionic Liquid Green Chem. 2015, 17, 2813-2824 10.1039/C4GC02448F
154. Choi, S.-A.; Lee, J.-S.; Oh, Y.-K.; Jeong, M.-J.; Kim, S. W.; Park, J.-Y. Lipid Extraction from Chlorella vulgaris by Molten-salt/ionic-liquid Mixtures Algal Res. 2014, 3, 44-48 10.1016/j.algal.2013.11.013
155. Choi, S.-A.; Jung, J.-Y.; Kim, K.; Kwon, J.-H.; Lee, J.-S.; Kim, S. W.; Park, J.-Y.; Yang, J.-W. Effects of Molten-salt/ionic-liquid Mixture on Extraction of Docosahexaenoic Acid (DHA)-rich Lipids from Aurantiochytrium sp. KRS101 Bioprocess Biosyst. Eng. 2014, 37, 2199-2204 10.1007/s00449-014-1197-2
156. Choi, S.-A.; Oh, Y.-K.; Jeong, M.-J.; Kim, S. W.; Lee, J.-S.; Park, J.-Y. Effects of Ionic Liquid Mixtures on Lipid Extraction from Chlorella vulgaris Renewable Energy 2014, 65, 169-174 10.1016/j.renene.2013.08.015
157. 4] Biomass Bioenergy 2013, 56, 99-103 10.1016/j.biombioe.2013.04.022
158. Essential Oil Market Size To Reach $11.67 Billion By 2022: Grand View Research, Inc., http://www.prnewswire.com/news-releases/essential-oil-market-size-to-reach-1167-billion-by-2022-grand-view-research-inc-531216151.html (accessed on March 24, 2016).
159. Zhai, Y.; Sun, S.; Wang, Z.; Cheng, J.; Sun, Y.; Wang, L.; Zhang, Y.; Zhang, H.; Yu, A. Microwave Extraction of Essential Oils from Dried Fruits of Illicium verum Hook. f. and Cuminum Cyminum L. using Ionic Liquid as the Microwave Absorption Medium J. Sep. Sci. 2009, 32, 3544-3549 10.1002/jssc.200910204
160. Zhai, Y.; Sun, S.; Song, D.; Sun, Y.; Zhang, Y.; Liu, H.; Zhang, H.; Yu, A. Rapid Extraction of Essential Oil from Dried Cinnamomum cassia Presl and Forsythia Suspensa (Thunb.) Vahl by Ionic Liquid Microwave Extraction Chin. J. Chem. 2010, 28, 2513-2519 10.1002/cjoc.201190031
161. Liu, Y.; Yang, L.; Zu, Y.; Zhao, C.; Zhang, L.; Zhang, Y.; Zhang, Z.; Wang, W. Development of an Ionic Liquid-based Microwave-assisted Method for Simultaneous Extraction and Distillation for Determination of Proanthocyanidins and Essential Oil in Cortex Cinnamomi Food Chem. 2012, 135, 2514-2521 10.1016/j.foodchem.2012.07.001
162. Jiao, J.; Gai, Q.-Y.; Fu, Y.-J.; Zu, Y.-G.; Luo, M.; Wang, W.; Zhao, C.-J. Microwave-assisted Ionic Liquids Pretreatment followed by Hydro-distillation for the Efficient Extraction of Essential Oil from Dryopteris Fragrans and Evaluation of its Antioxidant Efficacy in Sunflower Oil Storage J. Food Eng. 2013, 117, 477-485 10.1016/j.jfoodeng.2012.10.024
163. Jiao, J.; Gai, Q.-Y.; Fu, Y.-J.; Zu, Y.-G.; Luo, M.; Zhao, C.-J.; Li, C.-Y. Microwave-assisted Ionic Liquids Treatment followed by Hydro-distillation for the Efficient Isolation of Essential Oil from Fructus Forsythiae Seed Sep. Purif. Technol. 2013, 107, 228-237 10.1016/j.seppur.2013.01.009
164. Bica, K.; Gaertner, P.; Rogers, R. D. Ionic Liquids and Fragrances-Direct Isolation of Orange Essential Oil Green Chem. 2011, 13, 1997-1999 10.1039/c1gc15237h
165. Li, Z.-Y.; Zhang, S.-S.; Jie, X.; Qin, X.-M. Effect of Lithium Salts Addition on the Ionic Liquid Based Extraction of Essential Oil from Farfarae Flos J. Pharm. Biomed. Anal. 2015, 102, 509-513 10.1016/j.jpba.2014.09.026
166. Flamini, G.; Melai, B.; Pistelli, L.; Chiappe, C. How to Make a Green Product Greener: use of Ionic Liquids as Additives During Essential Oil Hydrodistillation RSC Adv. 2015, 5, 69894-69898 10.1039/C5RA12649E
167. Arce, A.; Marchiaro, A.; Rodríguez, O.; Soto, A. Essential Oil Terpenless by Extraction using Organic Solvents or Ionic Liquids AIChE J. 2006, 52, 2089-2097 10.1002/aic.10844
168. Arce, A.; Pobudkowska, A.; Rodríguez, O.; Soto, A. Citrus Essential Oil Terpenless by Extraction using 1-ethyl-3-methylimidazolium Ethylsulfate Ionic Liquid: Effect of the Temperature Chem. Eng. J. 2007, 133, 213-218 10.1016/j.cej.2007.01.035
169. Francisco, M.; Lago, S.; Soto, A.; Arce, A. Essential Oil Deterpenation by Solvent Extraction using 1-ethyl-3-methylimidazolium 2-(2-methoxyethoxy) Ethylsulfate Ionic Liquid Fluid Phase Equilib. 2010, 296, 149-153 10.1016/j.fluid.2010.03.019
170. Lago, S.; Rodríguez, H.; Soto, A.; Arce, A. Deterpenation of Citrus Essential Oil by Liquid-Liquid Extraction with 1-Alkyl-3-methylimidazolium Bis(trifluoromethylsulfonyl)amide Ionic Liquids J. Chem. Eng. Data 2011, 56, 1273-1281 10.1021/je1011339
171. Lago, S.; Rodríguez, H.; Soto, A.; Arce, A. Alkylpyridinium Alkylsulfate Ionic Liquids as Solvents for the Deterpenation of Citrus Essential Oil Sep. Sci. Technol. 2012, 47, 292-299 10.1080/01496395.2011.625388
172. Lago, S.; Rodríguez, H.; Arce, A.; Soto, A. Improved Concentration of Citrus Essential Oil by Solvent Extraction with Acetate Ionic Liquids Fluid Phase Equilib. 2014, 361, 37-44 10.1016/j.fluid.2013.10.036
173. Matsuda, H.; Norizuki, Y.; Kawai, M.; Kurihara, K.; Tochigi, K.; Ochi, K. Liquid-Liquid Equilibria for Extraction of Citrus Essential Oil Using Ionic Liquids J. Solution Chem. 2014, 43, 1561-1573 10.1007/s10953-014-0184-1
174. Martins, M. A. R.; Domańska, U.; Schröder, B.; Coutinho, J. A. P.; Pinho, S. P. Selection of Ionic Liquids to be Used as Separation Agents for Terpenes and Terpenoids ACS Sustainable Chem. Eng. 2016, 4, 548-556 10.1021/acssuschemeng.5b01357
175. Carotenoids Market worth $1,428.12 Million by 2019, http://www.marketsandmarkets.com/PressReleases/carotenoid.asp (accessed on March 24, 2016).
176. Bi, W.; Tian, M.; Zhou, J.; Row, K. H. Task-specific Ionic Liquid-assisted Extraction and Separation of Astaxanthin from Shrimp Waste J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2010, 878, 2243-2248 10.1016/j.jchromb.2010.06.034
177. Lee, Y. J.; Lee, Y. R.; Tang, B.; Row, K. H. Optimization of Extraction of Astaxanthin from Portunus Trituberculatus by Ionic Liquids Korean Soc. Biotechnol. Bioeng. J. 2013, 28, 238-243 10.7841/ksbbj.2013.28.4.238
178. Praveenkumar, R.; Lee, K.; Lee, J.; Oh, Y.-K. Breaking Dormancy: an Energy-efficient Means of Recovering Astaxanthin from Microalgae Green Chem. 2015, 17, 1226-1234 10.1039/C4GC01413H
179. Desai, R. K.; Streefland, M.; Wijffels, R. H.; Eppink, M. H. M. Novel Astaxanthin Extraction from Haematococcus Pluvialis using Cell Permeabilising Ionic Liquids Green Chem. 2016, 18, 1261-1267 10.1039/C5GC01301A
180. Martins, P. L.; de Rosso, V. V. Carotenoids Achieving from Tomatoes Discarded using Ionic Liquids as Extracting for Application in Food Industry; XIV Safety, Health and Environment World Congress, Cubatão, São Paulo, July 20-23, 2014; Science and Education Research Council: Great Britain, 2014; 35-38.
181. Lovejoy, K. S.; Davis, L. E.; McClellan, L. M.; Lillo, A. M.; Welsh, J. D.; Schmidt, E. N.; Sanders, C. K.; Lou, A. J.; Fox, D. T.; Koppisch, A. T. et al. Evaluation of Ionic Liquids on Phototrophic Microbes and their use in Biofuel Extraction and Isolation J. Appl. Phycol. 2013, 25, 973-981 10.1007/s10811-012-9907-0
182. Montalvo-Hernández, B.; Rito-Palomares, M.; Benavides, J. Recovery of Crocins from Saffron Stigmas (Crocus sativus) in Aqueous Two-phase Systems J. Chromatogr. A 2012, 1236, 7-15 10.1016/j.chroma.2012.03.012
183. Ribeiro, B. D.; Coelho, M. A. Z.; Marrucho, I. M. Extraction of Saponins from Sisal (Agave sisalana) and Juá (Ziziphus joazeiro) with Cholinium-based Ionic Liquids and Deep eutectic Solvents Eur. Food Res. Technol. 2013, 237, 965-975 10.1007/s00217-013-2068-9
184. Wang, P.; Ma, C.; Chen, S.; Zhu, S.; Lou, Z.; Wang, H. Ionic Liquid-based Ultrasonic/microwave-assisted Extraction of Steroidal Saponins from Dioscorea Zingiberensis CH Wright Trop. J. Pharm. Res. 2014, 13, 1339-1345 10.4314/tjpr.v13i8.20
185. Yang, Q.; Xing, H.; Cao, Y.; Su, B.; Yang, Y.; Ren, Q. Selective Separation of Tocopherol Homologues by Liquid-Liquid Extraction Using Ionic Liquids Ind. Eng. Chem. Res. 2009, 48, 6417-6422 10.1021/ie801847e
186. Yang, Q.; Xing, H.; Su, B.; Yu, K.; Bao, Z.; Yang, Y.; Ren, Q. Improved Separation Efficiency using Ionic Liquid-cosolvent Mixtures as the Extractant in liquid-liquid Extraction: A Multiple Adjustment and Synergistic Effect Chem. Eng. J. 2012, 181-182, 334-342 10.1016/j.cej.2011.11.089
187. Yang, Q.; Xing, H.; Su, B.; Bao, Z.; Wang, J.; Yang, Y.; Ren, Q. The Essential Role of Hydrogen-bonding Interaction in the Extractive Separation of Phenolic Compounds by Ionic Liquid AIChE J. 2013, 59, 1657-1667 10.1002/aic.13939
188. Liang, R.; Bao, Z.; Su, B.; Xing, H.; Yang, Q.; Yang, Y.; Ren, Q. Feasibility of Ionic Liquids as Extractants for Selective Separation of Vitamin D3 and Tachysterol3 by Solvent Extraction J. Agric. Food Chem. 2013, 61, 3479-3487 10.1021/jf305558b
189. Neves, C. M.; Ventura, S. P.; Freire, M. G.; Marrucho, I. M.; Coutinho, J. A. Evaluation of Cation Influence on the Formation and Extraction Capability of Ionic-liquid-based Aqueous Biphasic Systems J. Phys. Chem. B 2009, 113, 5194-5199 10.1021/jp900293v
190. Ventura, S. P. M.; Neves, C. M. S. S.; Freire, M. G.; Marrucho, I. M.; Oliveira, J.; Coutinho, J. A. P. Evaluation of Anion Influence on the Formation and Extraction Capacity of Ionic-Liquid-Based Aqueous Biphasic Systems J. Phys. Chem. B 2009, 113, 9304-9310 10.1021/jp903286d
191. Li, Z.; Pei, Y.; Liu, L.; Wang, J. (Liquid + Liquid) Equilibria for (Acetate-based Ionic Liquids + Inorganic Salts) Aqueous Two-phase Systems J. Chem. Thermodyn. 2010, 42, 932-937 10.1016/j.jct.2010.03.010
192. Pei, Y.; Li, Z.; Liu, L.; Wang, J. Partitioning Behavior of Amino Acids in Aqueous Two-phase Systems formed by Imidazolium Ionic Liquid and Dipotassium Hydrogen Phosphate J. Chromatogr. A 2012, 1231, 2-7 10.1016/j.chroma.2012.01.087
193. 4 Aqueous Biphasic Systems Int. J. Mol. Sci. 2010, 11, 1777-1791 10.3390/ijms11041777
194. Xie, Y.; Xing, H.; Yang, Q.; Bao, Z.; Su, B.; Ren, Q. Aqueous Biphasic System Containing Long Chain Anion-Functionalized Ionic Liquids for High-Performance Extraction ACS Sustainable Chem. Eng. 2015, 3, 3365-3372 10.1021/acssuschemeng.5b01068
195. Freire, M. G.; Neves, C. M. S. S.; Canongia Lopes, J. N.; Marrucho, I. M.; Coutinho, J. A. P.; Rebelo, L. P. N. Impact of Self-Aggregation on the Formation of Ionic-Liquid-Based Aqueous Biphasic Systems J. Phys. Chem. B 2012, 116, 7660-7668 10.1021/jp211132z
196. Zafarani-Moattar, M. T.; Hamzehzadeh, S. Partitioning of Amino Acids in the Aqueous Biphasic System Containing the Water-miscible Ionic Liquid 1-butyl-3-methylimidazolium Bromide and the Water-structuring Salt Potassium Citrate Biotechnol. Prog. 2011, 27, 986-997 10.1002/btpr.613
197. Passos, H.; Ferreira, A. R.; Cláudio, A. F. M.; Coutinho, J. A. P.; Freire, M. G. Characterization of Aqueous Biphasic Systems Composed of Ionic Liquids and a Citrate-based Biodegradable Salt Biochem. Eng. J. 2012, 67, 68-76 10.1016/j.bej.2012.05.004
198. Zafarani-Moattar, M. T.; Hamzehzadeh, S.; Nasiri, S. A new Aqueous Biphasic System Containing Polypropylene Glycol and a Water-miscible Ionic Liquid Biotechnol. Prog. 2012, 28, 146-156 10.1002/btpr.718
199. Wei, X.-L.; Wang, X.-H.; Ping, A. L.; Du, P.-P.; Sun, D.-Z.; Zhang, Q.-F.; Liu, J. Formation and Characteristics of Aqueous Two-phase Systems formed by a Cationic Surfactant and a Series of Ionic Liquids J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2013, 939, 1-9 10.1016/j.jchromb.2013.09.006
200. Luís, A.; Dinis, T. B. V.; Passos, H.; Taha, M.; Freire, M. G. Good's Buffers as Novel Phase-forming Components of Ionic-liquid-based Aqueous Biphasic Systems Biochem. Eng. J. 2015, 101, 142-149 10.1016/j.bej.2015.05.008
201. Pereira, J. F. B.; Lima, A. S.; Freire, M. G.; Coutinho, J. A. P. Ionic Liquids as Adjuvants for the Tailored Extraction of Biomolecules in Aqueous Biphasic Systems Green Chem. 2010, 12, 1661-1669 10.1039/c003578e
202. Hamzehzadeh, S.; Vasiresh, M. Ionic Liquid 1-butyl-3-methylimidazolium Bromide as a Promoter for the Formation and Extraction Capability of Poly(ethylene glycol)-potassium citrate Aqueous Biphasic System at T = 298.15 K Fluid Phase Equilib. 2014, 382, 80-88 10.1016/j.fluid.2014.08.029
203. Wu, D.; Zhou, Y.; Cai, P.; Shen, S.; Pan, Y. Specific Cooperative Effect for the Enantiomeric Separation of Amino Acids using Aqueous Two-phase Systems with Task-specific Ionic Liquids J. Chromatogr. A 2015, 1395, 65-72 10.1016/j.chroma.2015.03.047
204. Carda-Broch, S.; Berthod, A.; Armstrong, D. W. Solvent Properties of the 1-butyl-3-methylimidazolium Hexafluorophosphate Ionic Liquid Anal. Bioanal. Chem. 2003, 375, 191-199 10.1007/s00216-002-1684-1
205. Wang, J.; Pei, Y.; Zhao, Y.; Hu, Z. Recovery of Amino Acids by Imidazolium Based Ionic Liquids from Aqueous Media Green Chem. 2005, 7, 196-202 10.1039/b415842c
206. Tomé, L. I. N.; Catambas, V. R.; Teles, A. R. R.; Freire, M. G.; Marrucho, I. M.; Coutinho, J. A. P. Tryptophan Extraction using Hydrophobic Ionic Liquids Sep. Purif. Technol. 2010, 72, 167-173 10.1016/j.seppur.2010.02.002
207. Absalan, G.; Akhond, M.; Sheikhian, L. Partitioning of Acidic, Basic and Neutral Amino Acids into Imidazolium-based Ionic Liquids Amino Acids 2010, 39, 167-174 10.1007/s00726-009-0391-z
208. Seduraman, A.; Wu, P.; Klähn, M. Extraction of Tryptophan with Ionic Liquids Studied with Molecular Dynamics Simulations J. Phys. Chem. B 2012, 116, 296-304 10.1021/jp206748z
209. Vasantha, T.; Awanish, K.; Pankaj, A.; Pannuru, V.; Devi, R. S. R. The Solubility and Stability of Amino Acids in Biocompatible Ionic Liquids Protein Pept. Lett. 2013, 21, 15-24 10.2174/09298665113209990071
210. Huaxi, L.; Zhuo, L.; Jingmei, Y.; Changping, L.; Yansheng, C.; Qingshan, L.; Xiuling, Z.; Urs, W.-B. Liquid-liquid Extraction Process of Amino Acids by a new Amide-based Functionalized Ionic Liquid Green Chem. 2012, 14, 1721-1727 10.1039/c2gc16560k
211. Tang, F.; Zhang, Q.; Ren, D.; Nie, Z.; Liu, Q.; Yao, S. Functional Amino Acid Ionic Liquids as Solvent and Selector in Chiral Extraction J. Chromatogr. A 2010, 1217, 4669-4674 10.1016/j.chroma.2010.05.013
212. Wu, H.; Yao, S.; Qian, G.; Yao, T.; Song, H. A Resolution Approach of Racemic Phenylalanine with Aqueous Two-phase Systems of Chiral Tropine Ionic Liquids J. Chromatogr. A 2015, 1418, 150-157 10.1016/j.chroma.2015.09.058
213. Marwani, H. M. B.; Bakhsh, E. M.; Al-Turaif, H. A.; Asiri, A. M.; Khan, S. B. Enantioselective Separation and Detection of D-Phenylalanine Based on Newly Developed Chiral Ionic Liquid Immobilized Silica Gel Surface Int. J. Electrochem. Sci. 2014, 9, 7948-7964
214. Yang, L.; Hu, X.; Guan, P.; Li, J.; Wu, D.; Gao, B. Molecularly Imprinted Polymers for the Selective Recognition of l-phenylalanine based on 1-buty-3-methylimidazolium Ionic Liquid J. Appl. Polym. Sci. 2015, 132, 42485 10.1002/app.42485
215. Brunzel, N. A. Fundamentals of Urine and Body Fluid Analysis; Elsevier Health Sciences, 2013.
216. Hoffmann, R. In Advances in Health care Technology Care Shaping the Future of Medical; Spekowius, G.; Wendler, T., Eds.; Springer: Dordrecht, The Netherlands, 2006.
217. Patel, R.; Kumari, M.; Khan, A. B. Recent Advances in the Applications of Ionic Liquids in Protein Stability and Activity: A Review Appl. Biochem. Biotechnol. 2014, 172, 3701-3720 10.1007/s12010-014-0813-6
218. Zhao, H. Protein Stabilization and Enzyme Activation in Ionic Liquids: Specific Ion Effects J. Chem. Technol. Biotechnol. 2016, 91, 25-50 10.1002/jctb.4837
219. Ventura, S. P. M.; Santos, L. D. F.; Saraiva, J. A.; Coutinho, J. A. P. Ionic Liquids Microemulsions: The Key to Candida Antarctica Lipase B Superactivity Green Chem. 2012, 14, 1620-1625 10.1039/c2gc35197h
220. Kumari, M.; Maurya, J. K.; Singh, U. K.; Khan, A. B.; Ali, M.; Singh, P.; Patel, R. Spectroscopic and Docking Studies on the Interaction between Pyrrolidinium Based Ionic Liquid and Bovine Serum Albumin Spectrochim. Acta, Part A 2014, 124, 349-356 10.1016/j.saa.2014.01.012
221. Taha, M.; Quental, M. V.; Correia, I.; Freire, M. G.; Coutinho, J. A. P. Extraction and Stability of Bovine Serum Albumin (BSA) using Cholinium-based Good's Buffers Ionic Liquids Process Biochem. 2015, 50, 1158-1166 10.1016/j.procbio.2015.03.020
222. Du, Z.; Yu, Y. L.; Wang, J. H. Extraction of Proteins from Biological Fluids by use of an Ionic Liquid/Aqueous Two-phase System Chem.-Eur. J. 2007, 13, 2130-2137 10.1002/chem.200601234
223. Ruiz-Angel, M. J.; Pino, V.; Carda-Broch, S.; Berthod, A. Solvent Systems for Countercurrent Chromatography: An Aqueous Two phase Liquid System Based on a Room Temperature Ionic Liquid J. Chromatogr. A 2007, 1151, 65-73 10.1016/j.chroma.2006.11.072
224. Dreyer, S.; Salim, P.; Kragl, U. Driving Forces of Protein Partitioning in an Ionic Liquid-based Aqueous Two-phase System Biochem. Eng. J. 2009, 46, 176-185 10.1016/j.bej.2009.05.005
225. Pei, Y.; Wang, J.; Wu, K.; Xuan, X.; Lu, X. Ionic Liquid-based Aqueous Two-phase Extraction of Selected Proteins Sep. Purif. Technol. 2009, 64, 288-295 10.1016/j.seppur.2008.10.010
226. Lu, Y.; Lu, W.; Wang, W.; Guo, Q.; Yang, Y. Thermodynamic Studies of Partitioning Behavior of Cytochrome c in Ionic Liquid-based Aqueous Two-phase System Talanta 2011, 85, 1621-1626 10.1016/j.talanta.2011.06.058
227. Shu, Y.; Liu, M.; Chen, S.; Chen, X.; Wang, J. New Insight into Molecular Interactions of Imidazolium Ionic Liquids with Bovine Serum Albumin J. Phys. Chem. B 2011, 115, 12306-12314 10.1021/jp2071925
228. Yan, H.; Wu, J.; Dai, G.; Zhong, A.; Chen, H.; Yang, J.; Han, D. Interaction Mechanisms of Ionic Liquids [Cnmim]Br (n = 4, 6, 8, 10) with Bovine Serum Albumin J. Lumin. 2012, 132, 622-628 10.1016/j.jlumin.2011.10.026
229. Lin, X.; Wang, Y.; Zeng, Q.; Ding, X.; Chen, J. Extraction and Separation of Proteins by Ionic Liquid Aqueous Two-phase System Analyst 2013, 138, 6445-6453 10.1039/c3an01301d
230. Kohno, Y.; Ohno, H. Temperature-responsive Ionic Liquid/water Interfaces: Relation between Hydrophilicity of Ions and Dynamic Phase Change Phys. Chem. Chem. Phys. 2012, 14, 5063-5070 10.1039/c2cp24026b
231. Dreyer, S.; Kragl, U. Ionic Liquids for Aqueous Two-phase Extraction and Stabilization of Enzymes Biotechnol. Bioeng. 2008, 99, 1416-1424 10.1002/bit.21720
232. Pei, Y.; Li, L.; Li, Z.; Wu, C.; Wang, J. Partitioning Behavior of Wastewater Proteins in Some Ionic Liquids-Based Aqueous Two-Phase Systems Sep. Sci. Technol. 2012, 47, 277-283 10.1080/01496395.2011.609241
233. Sheikhian, L.; Akhond, M.; Absalan, G.; Goltz, D. M. Dye-Affinity Partitioning of Acidic, Basic, and Neutral Proteins in Ionic Liquid-Based Aqueous Biphasic Systems Sep. Sci. Technol. 2013, 48, 2372-2380 10.1080/01496395.2013.804086
234. Pei, Y.; Li, Z.; Liu, L.; Wang, J.; Wang, H. Selective Separation of Protein and Saccharides by Ionic Liquids Aqueous Two-phase Systems Sci. China Chem. 2010, 53, 1554-1560 10.1007/s11426-010-4025-9
235. Ding, X.; Wang, Y.; Zeng, Q.; Chen, J.; Huang, Y.; Xu, K. Design of Functional Guanidinium Ionic Liquid Aqueous Two-phase Systems for the Efficient Purification of Protein Anal. Chim. Acta 2014, 815, 22-32 10.1016/j.aca.2014.01.030
236. Zeng, Q.; Wang, Y.; Li, N.; Huang, X.; Ding, X.; Lin, X.; Huang, S.; Liu, X. Extraction of Proteins with Ionic Liquid Aqueous Two-phase System based on Guanidine Ionic Liquid Talanta 2013, 116, 409-416 10.1016/j.talanta.2013.06.011
237. Chen, J.; Wang, Y.; Zeng, Q.; Ding, X.; Huang, Y. Partition of Proteins with Extraction in Aqueous Two-phase System by Hydroxyl Ammonium-based Ionic Liquid Anal. Methods 2014, 6, 4067-4076 10.1039/c4ay00233d
238. Bisht, M.; Kumar, A.; Venkatesu, P. Analysis of the Driving Force that Rule the Stability of Lysozyme in Alkylammonium-based Ionic Liquids Int. J. Biol. Macromol. 2015, 81, 1074-1081 10.1016/j.ijbiomac.2015.09.036
239. Wu, C.; Wang, J.; Li, Z.; Jing, J.; Wang, H. Relative Hydrophobicity between the Phases and Partition of Cytochrome-c in Glycine Ionic Liquids Aqueous Two-phase Systems J. Chromatogr. A 2013, 1305, 1-6 10.1016/j.chroma.2013.06.066
240. Li, Z.; Liu, X.; Pei, Y.; Wang, J.; He, M. Design of Environmentally Friendly Ionic Liquid Aqueous Two-phase Systems for the Efficient and High Activity Extraction of Proteins Green Chem. 2012, 14, 2941-2950 10.1039/c2gc35890e
241. Huang, S.; Wang, Y.; Zhou, Y.; Li, L.; Zeng, Q.; Ding, X. Choline-like Ionic Liquid-based Aqueous Two-phase Extraction of Selected Proteins Anal. Methods 2013, 5, 3395-3402 10.1039/c3ay40377g
242. Quental, M. V.; Caban, M.; Pereira, M. M.; Stepnowski, P.; Coutinho, J. A. P.; Freire, M. G. Enhanced Extraction of Proteins using Cholinium-based Ionic Liquids as Phase-forming Components of Aqueous Biphasic Systems Biotechnol. J. 2015, 10, 1457-1466 10.1002/biot.201500003
243. Song, C. P.; Ramanan, R. N.; Vijayaraghavan, R.; MacFarlane, D. R.; Chan, E.-S.; Ooi, C.-W. Green, Aqueous Two-Phase Systems Based on Cholinium Aminoate Ionic Liquids with Tunable Hydrophobicity and Charge Density ACS Sustainable Chem. Eng. 2015, 3, 3291-3298 10.1021/acssuschemeng.5b00881
244. Greaves, T. L.; Drummond, C. J. Protic Ionic Liquids: Evolving Structure-Property Relationships and Expanding Applications Chem. Rev. 2015, 115, 11379-11448 10.1021/acs.chemrev.5b00158
245. Passos, H.; Luís, A.; Coutinho, J. A. P.; Freire, M. G. Thermoreversible (Ionic-Liquid-Based) Aqueous Biphasic Systems Sci. Rep. 2016, 6, 20276 10.1038/srep20276
246. Taha, M.; Almeida, M. R.; Silva, F. A.; Domingues, P.; Ventura, S. P.; Coutinho, J. A.; Freire, M. G. Novel Biocompatible and Self-buffering Ionic Liquids for Biopharmaceutical Applications Chem.-Eur. J. 2015, 21, 4781-4788 10.1002/chem.201405693
247. Desai, R. K.; Streefland, M.; Wijffels, R. H.; Eppink, M. H. M. Extraction and Stability of Selected Proteins in Ionic Liquid based Aqueous Two Phase Systems Green Chem. 2014, 16, 2670-2679 10.1039/C3GC42631A
248. Tan, Z.-j.; Li, F.-f.; Xu, X.-l.; Xing, J.-m. Simultaneous Extraction and Purification of Aloe Polysaccharides and Proteins using Ionic Liquid based Aqueous Two-phase System Coupled with Dialysis Membrane Desalination 2012, 286, 389-393 10.1016/j.desal.2011.11.053
249. Yan, J.-K.; Ma, H.-L.; Pei, J.-J.; Wang, Z.-B.; Wu, J.-Y. Facile and Effective Separation of Polysaccharides and Proteins from Cordyceps Sinensis Mycelia by Ionic Liquid Aqueous Two-phase System Sep. Purif. Technol. 2014, 135, 278-284 10.1016/j.seppur.2014.03.020
250. Pereira, M. M.; Pedro, S. N.; Quental, M. V.; Lima, á. S.; Coutinho, J. A. P.; Freire, M. G. Enhanced Extraction of Bovine Serum Albumin with Aqueous Biphasic Systems of Phosphonium- and Ammonium-based Ionic Liquids J. Biotechnol. 2015, 206, 17-25 10.1016/j.jbiotec.2015.03.028
251. Deive, F. J.; Rodriguez, A.; Pereiro, A. B.; Araujo, J. M. M.; Longo, M. A.; Coelho, M. A. Z.; Lopes, J. N. C.; Esperanca, J. M. S. S.; Rebelo, L. P. N.; Marrucho, I. M. Ionic Liquid-Based Aqueous Biphasic System for Lipase Extraction Green Chem. 2011, 13, 390-396 10.1039/C0GC00075B
252. Deive, F. J.; Rodríguez, A.; Rebelo, L. P. N.; Marrucho, I. M. Extraction of Candida Antarctica Lipase A from Aqueous Solutions using Imidazolium-based Ionic Liquids Sep. Purif. Technol. 2012, 97, 205-210 10.1016/j.seppur.2011.12.013
253. Ventura, S. P. M.; Sousa, S. G.; Freire, M. G.; Serafim, L. S.; Lima, á. S.; Coutinho, J. A. P. Design of Ionic Liquids for Lipase Purification J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2011, 879, 2679-2687 10.1016/j.jchromb.2011.07.022
254. Souza, R. L.; Lima, R. A.; Coutinho, J. A. P.; Soares, C. M. F.; Lima, á. S. Aqueous Two-phase Systems Based on Cholinium Salts and Tetrahydrofuran and their use for Lipase Purification Sep. Purif. Technol. 2015, 155, 118-126 10.1016/j.seppur.2015.05.021
255. Ventura, S. P. M.; Coutinho, J. A. P. In Ionic Liquids in Lipid Processing and Analysis; Guo, Z.; Cheong, L.-Z., Eds.; AOCS Press, 2016.
256. Lee, S. Y.; Vicente, F. A.; e Silva, F. A.; Sintra, T. E.; Taha, M.; Khoiroh, I.; Coutinho, J. A. P.; Show, P. L.; Ventura, S. P. M. Evaluating Self-buffering Ionic Liquids for Biotechnological Applications ACS Sustainable Chem. Eng. 2015, 3, 3420-3428 10.1021/acssuschemeng.5b01155
257. Bai, Z.; Chao, Y.; Zhang, M.; Han, C.; Zhu, W.; Chang, Y.; Li, H.; Sun, Y. Partitioning Behavior of Papain in Ionic Liquids-Based Aqueous Two-Phase Systems J. Chem. 2013, 2013, 1-6 10.1155/2013/938154
258. Cao, Q.; Quan, L.; He, C.; Li, N.; Li, K.; Liu, F. Partition of Horseradish Peroxidase with Maintained Activity in Aqueous Biphasic System Based on Ionic Liquid Talanta 2008, 77, 160-165 10.1016/j.talanta.2008.05.055
259. Simental-Martinez, J.; Rito-Palomares, M.; Benavides, J. Potential Application of Aqueous Two-phase Systems and Three-phase Partitioning for the Recovery of Superoxide Dismutase from a Clarified Homogenate of Kluyveromyces marxianus Biotechnol. Prog. 2014, 30, 1326-1334 10.1002/btpr.1979
260. Jiang, B.; Feng, Z.; Liu, C.; Xu, Y.; Li, D.; Ji, G. Extraction and Purification of Wheat-esterase using Aqueous Two-phase Systems of Ionic Liquid and Salt J. Food Sci. Technol. 2015, 52, 2878-2885 10.1007/s13197-014-1319-5
261. Cvjetko, M.; Žnidaršič-Plazl, P. In Ionic Liquids: Theory, Properties, New Approaches; InTech, 2011.
262. Novak, U.; Pohar, A.; Plazl, I.; Žnidaršič-Plazl, P. Ionic Liquid-based Aqueous two-phase Extraction within a Microchannel System Sep. Purif. Technol. 2012, 97, 172-178 10.1016/j.seppur.2012.01.033
263. Shimojo, K.; Kamiya, N.; Tani, F.; Naganawa, H.; Naruta, Y.; Goto, M. Extractive Solubilization, Structural Change, and Functional Conversion of Cytochrome C in Ionic Liquids via Crown Ether Complexation Anal. Chem. 2006, 78, 7735-7742 10.1021/ac0612877
264. Tzeng, Y.-P.; Shen, C.-W.; Yu, T. Liquid-liquid Extraction of Lysozyme using a Dye-modified Ionic Liquid J. Chromatogr. A 2008, 1193, 1-6 10.1016/j.chroma.2008.02.118
265. Kohno, Y.; Saita, S.; Murata, K.; Nakamura, N.; Ohno, H. Extraction of Proteins with Temperature Sensitive and Reversible Phase Change of Ionic Liquid/water Mixture Polym. Chem. 2011, 2, 862-867 10.1039/c0py00364f
266. Ito, Y.; Kohno, Y.; Nakamura, N.; Ohno, H. Design of Phosphonium-Type Zwitterion as an Additive to Improve Saturated Water Content of Phase-Separated Ionic Liquid from Aqueous Phase toward Reversible Extraction of Proteins Int. J. Mol. Sci. 2013, 14, 18350 10.3390/ijms140918350
267. Ren, G.; Gong, X.; Wang, B.; Chen, Y.; Huang, J. Affinity Ionic Liquids for the Rapid liquid-liquid Extraction Purification of Hexahistidine Tagged Proteins Sep. Purif. Technol. 2015, 146, 114-120 10.1016/j.seppur.2015.03.025
268. Xu, W.; Cao, H.; Ren, G.; Xie, H.; Huang, J.; Li, S. An AIL/IL-based Liquid/liquid Extraction System for the Purification of His-tagged Proteins Appl. Microbiol. Biotechnol. 2014, 98, 5665-5675 10.1007/s00253-014-5737-0
269. 6) Talanta 2008, 75, 1270-1278 10.1016/j.talanta.2008.01.044
270. Cheng, D.-H.; Chen, X.-W.; Shu, Y.; Wang, J.-H. Extraction of Cytochrome C by Ionic Liquid 1-Butyl-3-trimethylsilylimidazolium Hexafluorophosphate Chin. J. Anal. Chem. 2008, 36, 1187-1190 10.1016/S1872-2040(08)60066-3
271. Huh, Y. S.; Jeong, C.-M.; Chang, H. N.; Lee, S. Y.; Hong, W. H.; Park, T. J. Rapid Separation of Bacteriorhodopsin using a Laminar-flow Extraction System in a Microfluidic Device Biomicrofluidics 2010, 4, 014103 10.1063/1.3298608
272. Alvarez-Guerra, E.; Irabien, A. Ionic Liquid-Based Three Phase Partitioning (ILTPP) for Lactoferrin Recovery Sep. Sci. Technol. 2014, 49, 957-965 10.1080/01496395.2013.878722
273. Alvarez-Guerra, E.; Irabien, A. Ionic Liquid-based Three phase Partitioning (ILTPP) Systems for Whey Protein Recovery: Ionic Liquid Selection J. Chem. Technol. Biotechnol. 2015, 90, 939-946 10.1002/jctb.4401
274. Alvarez-Guerra, E.; Irabien, A.; Ventura, S. P. M.; Coutinho, J. A. P. Ionic Liquid Recovery Alternatives in Ionic Liquid-based Three-phase Partitioning (ILTPP) AIChE J. 2014, 60, 3577-3586 10.1002/aic.14530
275. Alvarez-Guerra, E.; Ventura, S. P. M.; Coutinho, J. A. P.; Irabien, A. Ionic Liquid-based Three Phase Partitioning (ILTPP) Systems: Ionic Liquid Recovery and Recycling Fluid Phase Equilib. 2014, 371, 67-74 10.1016/j.fluid.2014.03.009
276. Shu, Y.; Cheng, D.; Chen, X.; Wang, J. A Reverse Microemulsion of Water/AOT/1-butyl-3-methylimidazolium Hexafluorophosphate for Selective Extraction of Hemoglobin Sep. Purif. Technol. 2008, 64, 154-159 10.1016/j.seppur.2008.09.010
277. Mao, Q.-X.; Wang, H.; Shu, Y.; Chen, X.-W.; Wang, J.-H. A Dual-Ionic Liquid Microemulsion System for the Selective Isolation of Hemoglobin RSC Adv. 2014, 4, 8177-8182 10.1039/c3ra46736h
278. Vicente, F. A.; Malpiedi, L. P.; e Silva, F. A.; Pessoa, A., Jr; Coutinho, J. A. P.; Ventura, S. P. M. Design of Novel Aqueous Micellar Two-phase Systems using Ionic Liquids as Co-surfactants for the Selective Extraction of (Bio)molecules Sep. Purif. Technol. 2014, 135, 259-267 10.1016/j.seppur.2014.06.045
279. Vicente, F. A.; Lario, L. D.; Pessoa, A., Jr; Ventura, S. P. M. Recovery of Bromelain from Pineapple Stem Residues using Aqueous Micellar Two-phase Systems with Ionic Liquids as Co-surfactants Process Biochem. 2016, 51, 528-534 10.1016/j.procbio.2016.01.004
280. Ge, L.; Wang, X. T.; Tan, S. N.; Tsai, H. H.; Yong, J. W.; Hua, L. A novel method of protein extraction from yeast using Ionic Liquid Solution Talanta 2010, 81, 1861-1864 10.1016/j.talanta.2010.02.034
281. Fukaya, Y.; Sugimoto, A.; Ohno, H. Superior Solubility of Polysaccharides in Low Viscosity, Polar and Halogen-free 1,3-dialkylimidazolium Formates Biomacromolecules 2006, 7, 3295-3297 10.1021/bm060327d
282. Wang, X.; Zhang, X. Optimal Extraction and Hydrolysis of Chlorella pyrenoidosa Proteins Bioresour. Technol. 2012, 126, 307-313 10.1016/j.biortech.2012.09.059
283. Xie, H.; Li, S.; Zhang, S. Ionic Liquids as Novel Solvents for the Dissolution and Blending of Wool Keratin Fibers Green Chem. 2005, 7, 606-608 10.1039/b502547h
284. Plowman, J. E.; Clerens, S.; Lee, E.; Harland, D. P.; Dyer, J. M.; Deb-Choudhury, S. Ionic Liquid-assisted Extraction of Wool Keratin Proteins as an Aid to MS Identification Anal. Methods 2014, 6, 7305-7311 10.1039/C4AY01251H
285. Martins, M.; Vieira, F. A.; Correia, I.; Ferreira, R. A. S.; Abreu, H.; Coutinho, J. A. P.; Ventura, S. P. M. Recovery of Phycobiliproteins from the Red Macroalga Gracilaria sp. using Ionic Liquid Aqueous Solutions Green Chem. 2016, 18, 4287-4296 10.1039/C6GC01059H
286. Shu, Y.; Chen, X. W.; Wang, J. H. Ionic Liquid-polyvinyl Chloride Ionomer for Highly Selective Isolation of Basic Proteins Talanta 2010, 81, 637-642 10.1016/j.talanta.2009.12.059
287. Zhao, G.; Chen, S.; Chen, X. W.; He, R. H. Selective Isolation of Hemoglobin by use of Imidazolium-modified Polystyrene as Extractant Anal. Bioanal. Chem. 2013, 405, 5353-5358 10.1007/s00216-013-6889-y
288. Liu, Y.; Ma, R.; Deng, Q.; Zhang, L.; Liu, C.; Wang, S. Preparation of Ionic Liquid Polymer Materials and their Recognition Properties for Proteins RSC Adv. 2014, 4, 52147-52154 10.1039/C4RA05713A
289. Chen, J.; Wang, Y.; Ding, X.; Huang, Y.; Xu, K. Magnetic Solid-phase Extraction of Proteins based on Hydroxy Functional Ionic Liquid-modified Magnetic Nanoparticles Anal. Methods 2014, 6, 8358-8367 10.1039/C4AY01786B
290. Bezold, F.; Goll, J.; Minceva, M. Study of the Applicability of Non-conventional Aqueous two-phase Systems in Counter-current and Centrifugal Partition Chromatography J. Chromatogr. A 2015, 1388, 126-132 10.1016/j.chroma.2015.02.021
291. Gunn, P.; Walsh, S.; Roux, C. The Nucleic Acid Revolution Continues-will Forensic Biology become Forensic Molecular Biology? Front. Genet. 2014, 5, 44 10.3389/fgene.2014.00044
292. O'Reilly, P.; Wright, J. M. The Evolving Technology of DNA Fingerprinting and its Application to Fisheries and Aquaculture J. Fish Biol. 1995, 47, 29-55 10.1111/j.1095-8649.1995.tb06042.x
293. Hans, R.; Marwaha, N. Nucleic Acid Testing-benefits and Constraints Asian J. Transfus. Sci. 2014, 8, 2-3 10.4103/0973-6247.126679
294. Roth, C. M.; Yarmush, M. L. Nucleic Acid Biotechnology Annu. Rev. Biomed. Eng. 1999, 1, 265-297 10.1146/annurev.bioeng.1.1.265
295. Tan, S. C.; Yiap, B. C. DNA, RNA, and Protein Extraction: The Past and the Present. J. Biomed. Biotechnol. 2009, 2009, 1 10.1155/2009/574398.
296. Zhao, H. DNA Stability in Ionic Liquids and Deep Eutectic Solvents J. Chem. Technol. Biotechnol. 2015, 90, 19-25 10.1002/jctb.4511
297. Shi, Y.; Liu, Y.-L.; Lai, P.-Y.; Tseng, M.-C.; Tseng, M.-J.; Li, Y.; Chu, Y.-H. Ionic Liquids Promote PCR Amplification of DNA Chem. Commun. 2012, 48, 5325-5327 10.1039/c2cc31740k
298. Ohno, H.; Fukaya, Y.; Masuda, G.; Solvent For Dissolving Nucleic Acid, Nucleic Acid-Containing Solution And Method Of Preserving Nucleic Acid, 20070196826, 2005.
299. Wang, J.-H.; Cheng, D.-H.; Chen, X.-W.; Du, Z.; Fang, Z.-L. Direct Extraction of Double-Stranded DNA into Ionic Liquid 1-Butyl-3-methylimidazolium Hexafluorophosphate and its Quantification Anal. Chem. 2007, 79, 620-625 10.1021/ac061145c
300. Fister, S.; Fuchs, S.; Mester, P.; Kilpeläinen, I.; Wagner, M.; Rossmanith, P. The use of Ionic Liquids for Cracking Viruses for Isolation of Nucleic Acids Sep. Purif. Technol. 2015, 155, 38-44 10.1016/j.seppur.2015.03.035
301. Khimji, I.; Doan, K.; Bruggeman, K.; Huang, P.-J. J.; Vajha, P.; Liu, J. Extraction of DNA Staining Dyes from DNA using Hydrophobic Ionic Liquids Chem. Commun. 2013, 49, 4537-4539 10.1039/c3cc41364k
302. Clark, K. D.; Nacham, O.; Yu, H.; Li, T.; Yamsek, M. M.; Ronning, D. R.; Anderson, J. L. Extraction of DNA by Magnetic Ionic Liquids: Tunable Solvents for Rapid and Selective DNA Analysis Anal. Chem. 2015, 87, 1552-1559 10.1021/ac504260t
303. Clark, K. D.; Yamsek, M. M.; Nacham, O.; Anderson, J. L. Magnetic Ionic Liquids as PCR-Compatible Solvents for DNA Extraction from Biological Samples Chem. Commun. 2015, 51, 16771-16773 10.1039/C5CC07253K
304. Li, T.; Joshi, M. D.; Ronning, D. R.; Anderson, J. L. Ionic Liquids as Solvents for in Situ Dispersive Liquid-liquid Microextraction of DNA J. Chromatogr. A 2013, 1272, 8-14 10.1016/j.chroma.2012.11.055
305. Huang, D. J.; Huang, D. C. The Research for the Extraction of Yeast's Nucleic Acid with [BMIM] BF4-H2O-KH2PO4 Ionic Liquid Aqueous Two-Phase System Adv. Mater. Res. 2012, 455-456, 477-482 10.4028/www.scientific.net/AMR.455-456.477
306. Gonzalez García, E.; Ressmann, A. K.; Gaertner, P.; Zirbs, R.; Mach, R. L.; Krska, R.; Bica, K.; Brunner, K. Direct Extraction of Genomic DNA from Maize with Aqueous Ionic Liquid Buffer Systems for Applications in Genetically Modified Organisms Analysis Anal. Bioanal. Chem. 2014, 406, 7773-7784 10.1007/s00216-014-8204-y
307. Ressmann, A. K.; Garcia, E. G.; Khlan, D.; Gaertner, P.; Mach, R. L.; Krska, R.; Brunner, K.; Bica, K. Fast and Efficient Extraction of DNA from Meat and Meat Derived Products using Aqueous Ionic Liquid Buffer Systems New J. Chem. 2015, 39, 4994-5002 10.1039/C5NJ00178A
308. Wang, X.; Xing, L.; Shu, Y.; Chen, X.; Wang, J. Novel Polymeric Ionic Liquid Microspheres with High Exchange Capacity for Fast Extraction of Plasmid DNA Anal. Chim. Acta 2014, 837, 64-69 10.1016/j.aca.2014.06.002
309. Tateishi-Karimata, H.; Sugimoto, N. Structure, Stability and Behaviour of Nucleic Acids in Ionic Liquids Nucleic Acids Res. 2014, 42, 8831 10.1093/nar/gku499
310. Fujita, K.; Ohno, H. Stable G-quadruplex Structure in a Hydrated Ion Pair: Cholinium Cation and Dihydrogen Phosphate Anion Chem. Commun. 2012, 48, 5751-5753 10.1039/c2cc30554b
311. Mukesh, C.; Mondal, D.; Sharma, M.; Prasad, K. Rapid Dissolution of DNA in a Novel Bio-based Ionic Liquid with Long-term Structural and Chemical Stability: Successful Recycling of the Ionic Liquid for Reuse in the Process Chem. Commun. 2013, 49, 6849-6851 10.1039/c3cc42829j
312. Sharma, M.; Mondal, D.; Singh, N.; Trivedi, N.; Bhatt, J.; Prasad, K. High Concentration DNA Solubility in Bio-Ionic Liquids with Long-lasting Chemical and Structural Stability at Room Temperature RSC Adv. 2015, 5, 40546-40551 10.1039/C5RA03512K
313. Alfonsi, K.; Colberg, J.; Dunn, P. J.; Fevig, T.; Jennings, S.; Johnson, T. A.; Kleine, H. P.; Knight, C.; Nagy, M. A.; Perry, D. A. et al. Green Chemistry Tools to Influence a Medicinal Chemistry and Research Chemistry based Organisation Green Chem. 2008, 10, 31-36 10.1039/B711717E
314. Manley, J. B. In Green Chemistry Strategies for Drug Discovery; The Royal Society of Chemistry, 2015.
315. Roschangar, F.; Sheldon, R. A.; Senanayake, C. H. Overcoming Barriers to Green Chemistry in the Pharmaceutical Industry-the Green Aspiration Level Concept Green Chem. 2015, 17, 752-768 10.1039/C4GC01563K
316. Kümmerer, K. The Presence of Pharmaceuticals in the Environment due to Human use-Present Knowledge and Future Challenges J. Environ. Manage. 2009, 90, 2354-2366 10.1016/j.jenvman.2009.01.023
317. e Silva, F. A.; Sintra, T.; Ventura, S. P. M.; Coutinho, J. A. P. Recovery of Paracetamol from Pharmaceutical Wastes Sep. Purif. Technol. 2014, 122, 315-322 10.1016/j.seppur.2013.11.018
318. Constable, D. J. C.; Jimenez-Gonzalez, C.; Henderson, R. K. Perspective on Solvent Use in the Pharmaceutical Industry Org. Process Res. Dev. 2007, 11, 133-137 10.1021/op060170h
319. Grodowska, K.; Parczewski, A. Organic Solvents in the Pharmaceutical Industry Acta Polym. Pharm. 2010, 67, 3-12
320. Pfizer Pharmaceuticals: Green Chemistry Innovation and Business Strategy: https://www.acs.org/content/dam/acsorg/greenchemistry/industriainnovation/Pfizer-business-case-study.pdf (accessed on Feb 8, 2016).
321. Examples of Green Chemistry: http://www.acs.org/content/acs/en/greenchemistry/what-is-green-chemistry/examples.html (accessed on Feb 8, 2016).
322. Carr, R.; Ciccone, F.; Gabel, R.; Guinn, M.; Johnston, D.; Mastriona, J.; Vandermeer, T.; Groaning, M. Streamlined Process for the Esterification and Ketalization of Shikimic Acid en route to the Key Precursor for Oseltamivir Phosphate (Tamiflu) Green Chem. 2008, 10, 743-745 10.1039/b801582a
323. Dunn, P. J.; Wells, A. S.; Williams, M. T. In Green Chemistry in the Pharmaceutical Industry; Wiley-VCH, 2010.
324. Resende de Azevedo, J.; Letourneau, J.-J.; Espitalier, F.; Ré, M. I. Solubility of a New Cardioactive Prototype Drug in Ionic Liquids J. Chem. Eng. Data 2014, 59, 1766-1773 10.1021/je4009624
325. Melo, C. I.; Bogel-Łukasik, R.; Nunes da Ponte, M.; Bogel-Łukasik, E. Ammonium Ionic Liquids as Green Solvents for Drugs Fluid Phase Equilib. 2013, 338, 209-216 10.1016/j.fluid.2012.11.029
326. Faria, R. A.; da Ponte, M. N.; Bogel-Łukasik, E. Solubility Studies on the System of Trihexyl(tetradecyl)phosphonium bis[(trifluoromethyl)sulfonyl]amide) Ionic Liquid and Pharmaceutical and Bioactive Compounds Fluid Phase Equilib. 2015, 385, 1-9 10.1016/j.fluid.2014.10.033
327. Faria, R. A.; Bogel-Łukasik, E. Solubilities of Pharmaceutical and Bioactive Compounds in Trihexyl(tetradecyl)phosphonium Chloride Ionic Liquid Fluid Phase Equilib. 2015, 397, 18-25 10.1016/j.fluid.2015.03.053
328. Forte, A.; Melo, C. I.; Bogel-Łukasik, R.; Bogel-Łukasik, E. A Favourable Solubility of Isoniazid, an Antitubercular Antibiotic Drug, in Alternative Solvents Fluid Phase Equilib. 2012, 318, 89-95 10.1016/j.fluid.2012.01.022
329. Manic, M. S.; Najdanovic-Visak, V. Solubility of Erythromycin in Ionic Liquids J. Chem. Thermodyn. 2012, 44, 102-106 10.1016/j.jct.2011.08.004
330. Smith, K. B.; Bridson, R. H.; Leeke, G. A. Solubilities of Pharmaceutical Compounds in Ionic Liquids J. Chem. Eng. Data 2011, 56, 2039-2043 10.1021/je101040p
331. Mizuuchi, H.; Jaitely, V.; Murdan, S.; Florence, A. T. Room Temperature Ionic Liquids and their Mixtures: Potential Pharmaceutical Solvents Eur. J. Pharm. Sci. 2008, 33, 326-331 10.1016/j.ejps.2008.01.002
332. McCrary, P. D.; Beasley, P. A.; Gurau, G.; Narita, A.; Barber, P. S.; Cojocaru, O. A.; Rogers, R. D. Drug Specific, Tuning of an Ionic Liquid's Hydrophilic-lipophilic Balance to Improve Water Solubility of Poorly Soluble Active Pharmaceutical Ingredients New J. Chem. 2013, 37, 2196-2202 10.1039/c3nj00454f
333. Cull, S. G.; Holbrey, J. D.; Vargas-Mora, V.; Seddon, K. R.; Lye, G. J. Room-temperature Ionic Liquids as Replacements for Organic Solvents in Multiphase Bioprocess Operations Biotechnol. Bioeng. 2000, 69, 227-233 10.1002/(SICI)1097-0290(20000720)69:2<227::AID-BIT12>3.3.CO;2-S
334. Soto, A.; Arce, A.; Khoshkbarchi, M. K. Partitioning of Antibiotics in a Two-liquid Phase System Formed by Water and a Room Temperature Ionic Liquid Sep. Purif. Technol. 2005, 44, 242-246 10.1016/j.seppur.2005.01.013
335. Manic, M. S.; da Ponte, M. N.; Najdanovic-Visak, V. Recovery of Erythromycin from Aqueous Solutions with an Ionic Liquid and High-pressure Carbon Dioxide Chem. Eng. J. 2011, 171, 904-911 10.1016/j.cej.2011.04.037
336. Domańska, U.; Pobudkowska, A.; Bocheńska, P. Extraction of Nitrofurantoin using Ionic Liquids J. Chem. Eng. Data 2012, 57, 1894-1898 10.1021/je201301b
337. Matsumoto, M.; Ohtani, T.; Kondo, K. Comparison of Solvent Extraction and Supported Liquid Membrane Permeation using an Ionic Liquid for Concentrating Penicillin G J. Membr. Sci. 2007, 289, 92-96 10.1016/j.memsci.2006.11.046
338. Liu, Q.; Li, Y.; Li, W.; Liang, X.; Zhang, C.; Liu, H. Efficient Recovery of Penicillin G by a Hydrophobic Ionic Liquid ACS Sustainable Chem. Eng. 2016, 4, 609-615 10.1021/acssuschemeng.5b00975
339. Pei, Y.; Zhang, J.; Song, X.; Zhao, M.; Wang, J. Partition Behavior of Drug Molecules in Cholinium-Based Ionic Liquids Sep. Sci. Technol. 2015, 50, 1641-1646 10.1080/01496395.2014.978475
340. Vitasari, C. R.; Gramblička, M.; Gibcus, K.; Visser, T. J.; Geertman, R.; Schuur, B. Separating Closely Resembling Steroids with Ionic Liquids in liquid-liquid Extraction Systems Sep. Purif. Technol. 2015, 155, 58-65 10.1016/j.seppur.2015.04.002
341. Yue, Y.; Jiang, X.-Y.; Yu, J.-G.; Tang, K.-W. Enantioseparation of Mandelic Acid Enantiomers in Ionic Liquid Aqueous Two-phase Extraction Systems Chem. Pap. 2013, 68, 465-471 10.2478/s11696-013-0467-9
342. Zhang, Z.-J.; Pan, J.; Ma, B.-D.; Xu, J.-H. In Bioreactor Engineering Research and Industrial Applications I: Cell Factories; Ye, Q.; Bao, J.; Zhong, J.-J., Eds.; Springer: Berlin, 2016.
343. Wang, H.; Gurau, G.; Kelley, S. P.; Myerson, A. S.; Rogers, R. D. Hydrophobic vs. Hydrophilic Ionic Liquid Separations Strategies in Support of Continuous Pharmaceutical Manufacturing RSC Adv. 2013, 3, 10019-10026 10.1039/c3ra41082j
344. Harini, M.; Jain, S.; Adhikari, J.; Noronha, S. B.; Yamuna Rani, K. Design of an Ionic Liquid as a Solvent for the Extraction of a Pharmaceutical Intermediate Sep. Purif. Technol. 2015, 155, 45-57 10.1016/j.seppur.2015.07.040
345. Li, S. H.; He, C. Y.; Liu, H. W.; Li, K. A.; Liu, F. Ionic Liquid-salt Aqueous Two-phase System, a Novel System for the Extraction of Abused Drugs J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2005, 16, 1074-1076 10.1016/j.jchromb.2005.08.005
346. Ma, C.-h.; Wang, L.; Yan, Y.-s.; Che, G.-b.; Yin, Y.-s.; Wang, R.-z.; Li, D.-y. Extraction of Tetracycline via Ionic Liquid Two-phase System Chem. Res. Chin. Univ 2009, 25, 832-835
347. Pang, J.; Han, C.; Chao, Y.; Jing, L.; Ji, H.; Zhu, W.; Chang, Y.; Li, H. Partitioning Behavior of Tetracycline in Hydrophilic Ionic Liquids Two-Phase Systems Sep. Sci. Technol. 2015, 50, 1993-1998 10.1080/01496395.2015.1018436
348. Marques, C. F. C.; Mourão, T.; Neves, C. M. S. S.; Lima, á. S.; Boal-Palheiros, I.; Coutinho, J. A. P.; Freire, M. G. Aqueous Biphasic Systems Composed of Ionic Liquids and Sodium Carbonate as Enhanced Routes for the Extraction of Tetracycline Biotechnol. Prog. 2013, 29, 645-654 10.1002/btpr.1708
349. Shahriari, S.; Tome, L. C.; Araujo, J. M. M.; Rebelo, L. P. N.; Coutinho, J. A. P.; Marrucho, I. M.; Freire, M. G. Aqueous Biphasic Systems: a Benign Route using Cholinium-based Ionic Liquids RSC Adv. 2013, 3, 1835-1843 10.1039/C2RA22972B
350. Pereira, J. F. B.; Vicente, F.; Santos-Ebinuma, V. C.; Araújo, J. M.; Pessoa, A.; Freire, M. G.; Coutinho, J. A. P. Extraction of Tetracycline from Fermentation Broth using Aqueous Two-phase Systems Composed of Polyethylene Glycol and Cholinium-based Salts Process Biochem. 2013, 48, 716-722 10.1016/j.procbio.2013.02.025
351. Liu, Q.; Yu, J.; Li, W.; Hu, X.; Xia, H.; Liu, H.; Yang, P. Partitioning Behavior of Penicillin G in Aqueous Two Phase System Formed by Ionic Liquids and Phosphate Sep. Sci. Technol. 2006, 41, 2849-2858 10.1080/01496390600786135
352. Jiang, Y.; Xia, H.; Guo, C.; Mahmood, I.; Liu, H. Phenomena and Mechanism for Separation and Recovery of Penicillin in Ionic Liquids Aqueous Solution Ind. Eng. Chem. Res. 2007, 46, 6303-6312 10.1021/ie070325p
353. Jiang, Y.; Xia, H.; Yu, J.; Guo, C.; Liu, H. Hydrophobic Ionic Liquids-assisted Polymer Recovery during Penicillin Extraction in Aqueous Two-phase System Chem. Eng. J. 2009, 147, 22-26 10.1016/j.cej.2008.11.012
354. 4 J. Chem. 2013, 2013, 1-5 10.1155/2013/193671
355. Han, J.; Wang, Y.; Chen, C.; Kang, W.; Liu, Y.; Xu, K.; Ni, L. (Liquid + Liquid) Equilibria and Extraction Capacity of (Imidazolium Ionic Liquids + Potassium Tartrate) Aqueous Two-phase Systems J. Mol. Liq. 2014, 193, 23-28 10.1016/j.molliq.2013.12.022
356. Zhang, W.; Zhang, G.; Han, J.; Yan, Y.; Chen, B.; Sheng, C.; Liu, Y. Phase Equilibrium and Chloramphenicol Partitioning in Aqueous two-phase System Composed of 1-hydroxylhexyl-3-methylimidazolium Chloride-salt J. Mol. Liq. 2014, 193, 226-231 10.1016/j.molliq.2013.12.047
357. Chen, L.-L.; Li, F.-F.; Tan, Z.-J. Chiral Separation of α-cyclohexylmandelic Acid Enantiomers using Ionic Liquid/salt Aqueous Two-phase System Chem. Pap. 2015, 69, 1465-1472 10.1515/chempap-2015-0162
358. Zawadzki, M.; e Silva, F. A.; Domańska, U.; Coutinho, J. A. P.; Ventura, S. P. M. Recovery of an Antidepressant from Pharmaceutical Wastes using Ionic Liquids-based Aqueous Biphasic Systems Green Chem. 2016, 18, 3527-3536 10.1039/C5GC03052H
359. e Silva, F. A.; Caban, M.; Stepnowski, P.; Coutinho, J. A. P.; Ventura, S. P. M. Recovery of Ibuprofen from Pharmaceutical Wastes using Ionic Liquids Green Chem. 2016, 18, 3749-3757 10.1039/C6GC00261G
360. Kroon, M. C.; van Spronsen, J.; Peters, C. J.; Sheldon, R. A.; Witkamp, G.-J. Recovery of Pure Products from Ionic Liquids using Supercritical Carbon Dioxide as a co-solvent in Extractions or as an Anti-solvent in Precipitations Green Chem. 2006, 8, 246-249 10.1039/B512303H
361. Kroon, M. C.; Toussaint, V. A.; Shariati, A.; Florusse, L. J.; van Spronsen, J.; Witkamp, G.-J.; Peters, C. J. Crystallization of an Organic Compound from an Ionic Liquid using Carbon Dioxide as Anti-solvent Green Chem. 2008, 10, 333-336 10.1039/b712848g
362. Kühne, E.; Peters, C. J.; van Spronsen, J.; Witkamp, G.-J. Solubility of Carbon Dioxide in Systems with [bmim][BF4] and some Selected Organic Compounds of interest for the Pharmaceutical Industry Green Chem. 2006, 8, 287-291 10.1039/b513132d
363. 2 to Determine Optimum Regions for Green Processing Green Chem. 2008, 10, 762-766 10.1039/b801068d
364. Weber, C. C.; Kunov-Kruse, A. J.; Rogers, R. D.; Myerson, A. S. Manipulation of Ionic Liquid Anion-solute-antisolvent Interactions for the Purification of Acetaminophen Chem. Commun. 2015, 51, 4294-4297 10.1039/C5CC00198F
365. Viçosa, A.; Letourneau, J.-J.; Espitalier, F.; Inês Ré, M. An Innovative Antisolvent Precipitation Process as a Promising Technique to Prepare Ultrafine Rifampicin Particles J. Cryst. Growth 2012, 342, 80-87 10.1016/j.jcrysgro.2011.09.012
366. An, J.-H.; Kim, J.-M.; Chang, S.-M.; Kim, W.-S. Application of Ionic Liquid to Polymorphic Design of Pharmaceutical Ingredients Cryst. Growth Des. 2010, 10, 3044-3050 10.1021/cg1001489
367. An, J.-H.; Kim, W.-S. Antisolvent Crystallization using Ionic Liquids as Solvent and Antisolvent for Polymorphic Design of Active Pharmaceutical Ingredient Cryst. Growth Des. 2013, 13, 31-39 10.1021/cg300730w
368. Smith, K. B.; Bridson, R. H.; Leeke, G. A. Crystallisation Control of Paracetamol from Ionic Liquids CrystEngComm 2014, 16, 10797-10803 10.1039/C4CE01796J
369. Weber, C. C.; Kulkarni, S. A.; Kunov-Kruse, A. J.; Rogers, R. D.; Myerson, A. S. The Use of Cooling Crystallization in an Ionic Liquid System for the Purification of Pharmaceuticals Cryst. Growth Des. 2015, 15, 4946-4951 10.1021/acs.cgd.5b00855
370. Calisto, V.; Esteves, V. I. Psychiatric Pharmaceuticals in the Environment Chemosphere 2009, 77, 1257-1274 10.1016/j.chemosphere.2009.09.021
371. Li, C.-X.; Han, J.; Wang, Y.; Yan, Y.-S.; Xu, X.-H.; Pan, J.-M. Extraction and Mechanism Investigation of Trace Roxithromycin in Real Water Samples by use of Ionic Liquid-salt Aqueous Two-phase System Anal. Chim. Acta 2009, 653, 178-183 10.1016/j.aca.2009.09.011
372. Wang, Y.; Han, J.; Xie, X.-q.; Li, C.-x. Extraction of Trace Acetylspiramycin in Real Aqueous Environments using Aqueous Two-phase System of Ionic Liquid 1-butyl-3-methylimidazolium Tetrafluoroborate and Phosphate Cent. Eur. J. Chem. 2010, 8, 1185-1191 10.2478/s11532-010-0080-5
373. Yang, X.; Zhang, S.; Yu, W.; Liu, Z.; Lei, L.; Li, N.; Zhang, H.; Yu, Y. Ionic Liquid-anionic Surfactant based Aqueous Two-phase Extraction for Determination of Antibiotics in Honey by High-performance Liquid Chromatography Talanta 2014, 124, 1-6 10.1016/j.talanta.2014.02.039
374. Dinis, T. B. V.; Passos, H.; Lima, D. L. D.; Esteves, V. I.; Coutinho, J. A. P.; Freire, M. G. One-step Extraction and Concentration of Estrogens for an Adequate Monitoring of Wastewater using Ionic-liquid-based Aqueous Biphasic Systems Green Chem. 2015, 17, 2570-2579 10.1039/C5GC00077G
375. Han, J.; Wang, Y.; Yu, C.; Li, C.; Yan, Y.; Liu, Y.; Wang, L. Separation, Concentration and Determination of Chloramphenicol in Environment and Food using an Ionic Liquid/salt Aqueous Two-phase Flotation System Coupled with High-performance Liquid Chromatography Anal. Chim. Acta 2011, 685, 138-145 10.1016/j.aca.2010.11.033
376. Han, J.; Wang, Y.; Yu, C.-l.; Yan, Y.-S.; Xie, X.-Q. Extraction and Determination of Chloramphenicol in Feed Water, Milk, and Honey Samples using an Ionic Liquid/sodium Citrate Aqueous Two-phase System Coupled with High-performance Liquid Chromatography Anal. Bioanal. Chem. 2011, 399, 1295-1304 10.1007/s00216-010-4376-2
377. Xu, X.; Su, R.; Zhao, X.; Liu, Z.; Zhang, Y.; Li, D.; Li, X.; Zhang, H.; Wang, Z. Ionic Liquid-Based Microwave-assisted Dispersive Liquid-liquid Microextraction and Derivatization of Sulfonamides in River Water, Honey, Milk, and Animal Plasma Anal. Chim. Acta 2011, 707, 92-99 10.1016/j.aca.2011.09.018
378. Yao, C.; Li, T.; Twu, P.; Pitner, W. R.; Anderson, J. L. Selective Extraction of Emerging Contaminants from Water Samples by Dispersive Liquid-liquid Microextraction using Functionalized Ionic Liquids J. Chromatogr. A 2011, 1218, 1556-1566 10.1016/j.chroma.2011.01.035
379. Gao, S.; Jin, H.; You, J.; Ding, Y.; Zhang, N.; Wang, Y.; Ren, R.; Zhang, R.; Zhang, H. Ionic Liquid-based Homogeneous Liquid-liquid Microextraction for the Determination of Antibiotics in Milk by High-performance Liquid Chromatography J. Chromatogr. A 2011, 1218, 7254-7263 10.1016/j.chroma.2011.08.063
380. Vázquez, M. M. P.; Vázquez, P. P.; Galera, M. M.; García, M. D. G. Determination of Eight Fluoroquinolones in Groundwater Samples with Ultrasound-assisted Ionic Liquid Dispersive Liquid-liquid Microextraction prior to High-performance Liquid Chromatography and Fluorescence Detection Anal. Chim. Acta 2012, 748, 20-27 10.1016/j.aca.2012.08.042
381. Song, J.; Zhang, Z. H.; Zhang, Y. Q.; Feng, C.; Wang, G. N.; Wang, J. P. Ionic Liquid Dispersive Liquid-liquid Microextraction Combined with High Performance Liquid Chromatography for Determination of Tetracycline Drugs in Eggs Anal. Methods 2014, 6, 6459-6466 10.1039/C4AY01079E
382. Toledo-Neira, C.; álvarez-Lueje, A. Ionic Liquids for Improving the Extraction of NSAIDs in Water Samples using Dispersive Liquid-liquid Microextraction by High Performance Liquid Chromatography-diode Array-fluorescence Detection Talanta 2015, 134, 619-626 10.1016/j.talanta.2014.11.067
383. álvarez, M. S.; Esperança, J. M. S. S.; Deive, F. J.; Sanromán, M. á.; Rodríguez, A. A Biocompatible Stepping Stone for the Removal of Emerging Contaminants Sep. Purif. Technol. 2015, 153, 91-98 10.1016/j.seppur.2015.08.039
384. Almeida, H. F. D.; Freire, M. G.; Marrucho, I. M. Improved Extraction of Fluoroquinolones with Recyclable Ionic-liquid-based Aqueous biphasic Systems Green Chem. 2016, 18, 2717-2725 10.1039/C5GC02464A
385. Ventura, S. P. M.; Coutinho, J. A. P. In Toward the Recovery and Reuse of the ABS Phase-Forming Components In Ionic-Liquid-Based Aqueous Biphasic Systems: Fundamentals and Applications; Freire, M. G., Ed.; Springer, 2016.