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Volumn 37, Issue 5, 2017, Pages 764-777

ATVB distinguished scientist award: How Costimulatory and Coinhibitory pathways shape atherosclerosis

Author keywords

antigen presenting cells; atherosclerosis; B lymphocytes; immunoglobulins; receptors, tumor necrosis factor

Indexed keywords

B7 ANTIGEN; CD137 ANTIGEN; CD137 LIGAND; CD27 ANTIGEN; CD28 ANTIGEN; CD30 ANTIGEN; CD30 LIGAND; CD4 ANTIGEN; CD40 ANTIGEN; CD40 LIGAND; CD70 ANTIGEN; CD86 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 ANTIBODY; GLUCOCORTICOIDINDUCED TUMOR NECROSIS FACTOR RECEPTOR RELATED PROTEIN; HERPESVIRUS ENTRY MEDIATOR; MONOCLONAL ANTIBODY; OX40 LIGAND; OX40 PROTEIN; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 LIGAND 2; PROGRAMMED DEATH 1 RECEPTOR; PROTEIN; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; ANTIBODY; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR;

EID: 85016630909     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.117.308611     Document Type: Review
Times cited : (26)

References (213)
  • 1
    • 84871036375 scopus 로고    scopus 로고
    • Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: A systematic analysis for the Global Burden of Disease Study 2010
    • Lozano R, Naghavi M, Foreman K, Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012 380 2095 2128. doi: 10.1016/S0140-6736(12)61728-0.
    • (2012) Lancet , vol.380 , pp. 2095-2128
    • Lozano, R.1    Naghavi, M.2    Foreman, K.3
  • 2
    • 84874814357 scopus 로고    scopus 로고
    • The prevention and regression of atherosclerotic plaques: Emerging treatments
    • Kalanuria AA, Nyquist P, Ling G, The prevention and regression of atherosclerotic plaques: emerging treatments. Vasc Health Risk Manag 2012 8 549 561. doi: 10.2147/VHRM.S27764.
    • (2012) Vasc Health Risk Manag , vol.8 , pp. 549-561
    • Kalanuria, A.A.1    Nyquist, P.2    Ling, G.3
  • 3
    • 0034648768 scopus 로고    scopus 로고
    • Atherosclerosis
    • Lusis AJ, Atherosclerosis. Nature 2000 407 233 241. doi: 10.1038/35025203.
    • (2000) Nature , vol.407 , pp. 233-241
    • Lusis, A.J.1
  • 4
    • 84897018581 scopus 로고    scopus 로고
    • The influence of innate and adaptive immune responses on atherosclerosis
    • Witztum JL, Lichtman AH, The influence of innate and adaptive immune responses on atherosclerosis. Annu Rev Pathol 2014 9 73 102. doi: 10.1146/annurev-pathol-020712-163936.
    • (2014) Annu Rev Pathol , vol.9 , pp. 73-102
    • Witztum, J.L.1    Lichtman, A.H.2
  • 5
    • 81255188900 scopus 로고    scopus 로고
    • Atherosclerosis: Current pathogenesis and therapeutic options
    • Weber C, Noels H, Atherosclerosis: current pathogenesis and therapeutic options. Nat Med 2011 17 1410 1422. doi: 10.1038/nm.2538.
    • (2011) Nat Med , vol.17 , pp. 1410-1422
    • Weber, C.1    Noels, H.2
  • 6
    • 67650720510 scopus 로고    scopus 로고
    • Immune and inflammatory mechanisms of atherosclerosis (∗)
    • Galkina E, Ley K, Immune and inflammatory mechanisms of atherosclerosis (∗). Annu Rev Immunol 2009 27 165 197. doi: 10.1146/annurev.immunol.021908.132620.
    • (2009) Annu Rev Immunol , vol.27 , pp. 165-197
    • Galkina, E.1    Ley, K.2
  • 7
    • 84862816264 scopus 로고    scopus 로고
    • Thioredoxin interacting protein promotes endothelial cell inflammation in response to disturbed flow by increasing leukocyte adhesion and repressing Kruppel-like factor 2
    • Wang XQ, Nigro P, World C, Fujiwara K, Yan C, Berk BC, Thioredoxin interacting protein promotes endothelial cell inflammation in response to disturbed flow by increasing leukocyte adhesion and repressing Kruppel-like factor 2. Circ Res 2012 110 560 568. doi: 10.1161/CIRCRESAHA.111.256362.
    • (2012) Circ Res , vol.110 , pp. 560-568
    • Wang, X.Q.1    Nigro, P.2    World, C.3    Fujiwara, K.4    Yan, C.5    Berk, B.C.6
  • 8
    • 84940426168 scopus 로고    scopus 로고
    • Disturbed laminar blood flow vastly augments lipoprotein retention in the artery wall: A key mechanism distinguishing susceptible from resistant sites
    • Steffensen LB, Mortensen MB, Kjolby M, Hagensen MK, Oxvig C, Bentzon JF, Disturbed laminar blood flow vastly augments lipoprotein retention in the artery wall: a key mechanism distinguishing susceptible from resistant sites. Arterioscler Thromb Vasc Biol 2015 35 1928 1935. doi: 10.1161/ATVBAHA.115.305874.
    • (2015) Arterioscler Thromb Vasc Biol , vol.35 , pp. 1928-1935
    • Steffensen, L.B.1    Mortensen, M.B.2    Kjolby, M.3    Hagensen, M.K.4    Oxvig, C.5    Bentzon, J.F.6
  • 9
    • 52949118482 scopus 로고    scopus 로고
    • The multifaceted contributions of leukocyte subsets to atherosclerosis: Lessons from mouse models
    • Weber C, Zernecke A, Libby P, The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models. Nat Rev Immunol 2008 8 802 815. doi: 10.1038/nri2415.
    • (2008) Nat Rev Immunol , vol.8 , pp. 802-815
    • Weber, C.1    Zernecke, A.2    Libby, P.3
  • 10
    • 84883800208 scopus 로고    scopus 로고
    • Local proliferation dominates lesional macrophage accumulation in atherosclerosis
    • Robbins CS, Hilgendorf I, Weber GF, Local proliferation dominates lesional macrophage accumulation in atherosclerosis. Nat Med 2013 19 1166 1172. doi: 10.1038/nm.3258.
    • (2013) Nat Med , vol.19 , pp. 1166-1172
    • Robbins, C.S.1    Hilgendorf, I.2    Weber, G.F.3
  • 11
    • 84855928422 scopus 로고    scopus 로고
    • The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques
    • van Gils JM, Derby MC, Fernandes LR, The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques. Nat Immunol 2012 13 136 143. doi: 10.1038/ni.2205.
    • (2012) Nat Immunol , vol.13 , pp. 136-143
    • Van Gils, J.M.1    Derby, M.C.2    Fernandes, L.R.3
  • 15
    • 79955535643 scopus 로고    scopus 로고
    • Macrophages in the pathogenesis of atherosclerosis
    • Moore KJ, Tabas I, Macrophages in the pathogenesis of atherosclerosis. Cell 2011 145 341 355. doi: 10.1016/j.cell.2011.04.005.
    • (2011) Cell , vol.145 , pp. 341-355
    • Moore, K.J.1    Tabas, I.2
  • 16
    • 76349096459 scopus 로고    scopus 로고
    • Resident intimal dendritic cells accumulate lipid and contribute to the initiation of atherosclerosis
    • Paulson KE, Zhu SN, Chen M, Nurmohamed S, Jongstra-Bilen J, Cybulsky MI, Resident intimal dendritic cells accumulate lipid and contribute to the initiation of atherosclerosis. Circ Res 2010 106 383 390. doi: 10.1161/CIRCRESAHA.109.210781.
    • (2010) Circ Res , vol.106 , pp. 383-390
    • Paulson, K.E.1    Zhu, S.N.2    Chen, M.3    Nurmohamed, S.4    Jongstra-Bilen, J.5    Cybulsky, M.I.6
  • 17
    • 4143092691 scopus 로고    scopus 로고
    • Emigration of monocyte-derived cells from atherosclerotic lesions characterizes regressive, but not progressive, plaques
    • Llodrá J, Angeli V, Liu J, Trogan E, Fisher EA, Randolph GJ, Emigration of monocyte-derived cells from atherosclerotic lesions characterizes regressive, but not progressive, plaques. Proc Natl Acad Sci U S A 2004 101 11779 11784. doi: 10.1073/pnas.0403259101.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 11779-11784
    • Llodrá, J.1    Angeli, V.2    Liu, J.3    Trogan, E.4    Fisher, E.A.5    Randolph, G.J.6
  • 18
    • 0021929537 scopus 로고
    • Expression of class II transplantation antigen on vascular smooth muscle cells in human atherosclerosis
    • Jonasson L, Holm J, Skalli O, Gabbiani G, Hansson GK, Expression of class II transplantation antigen on vascular smooth muscle cells in human atherosclerosis. J Clin Invest 1985 76 125 131. doi: 10.1172/JCI111934.
    • (1985) J Clin Invest , vol.76 , pp. 125-131
    • Jonasson, L.1    Holm, J.2    Skalli, O.3    Gabbiani, G.4    Hansson, G.K.5
  • 20
    • 33646692002 scopus 로고    scopus 로고
    • Lymphocyte recruitment into the aortic wall before and during development of atherosclerosis is partially L-selectin dependent
    • Galkina E, Kadl A, Sanders J, Varughese D, Sarembock IJ, Ley K, Lymphocyte recruitment into the aortic wall before and during development of atherosclerosis is partially L-selectin dependent. J Exp Med 2006 203 1273 1282. doi: 10.1084/jem.20052205.
    • (2006) J Exp Med , vol.203 , pp. 1273-1282
    • Galkina, E.1    Kadl, A.2    Sanders, J.3    Varughese, D.4    Sarembock, I.J.5    Ley, K.6
  • 21
    • 84901388107 scopus 로고    scopus 로고
    • Artery tertiary lymphoid organs contribute to innate and adaptive immune responses in advanced mouse atherosclerosis
    • Mohanta SK, Yin C, Peng L, Srikakulapu P, Bontha V, Hu D, Weih F, Weber C, Gerdes N, Habenicht AJ, Artery tertiary lymphoid organs contribute to innate and adaptive immune responses in advanced mouse atherosclerosis. Circ Res 2014 114 1772 1787. doi: 10.1161/CIRCRESAHA.114.301137.
    • (2014) Circ Res , vol.114 , pp. 1772-1787
    • Mohanta, S.K.1    Yin, C.2    Peng, L.3    Srikakulapu, P.4    Bontha, V.5    Hu, D.6    Weih, F.7    Weber, C.8    Gerdes, N.9    Habenicht, A.J.10
  • 22
    • 21844450539 scopus 로고    scopus 로고
    • Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells
    • Okada T, Miller MJ, Parker I, Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells. PLoS Biol 2005 3 e150
    • (2005) PLoS Biol , vol.3 , pp. e150
    • Okada, T.1    Miller, M.J.2    Parker, I.3
  • 24
    • 58149097584 scopus 로고    scopus 로고
    • The who, how and where of antigen presentation to B cells
    • Batista FD, Harwood NE, The who, how and where of antigen presentation to B cells. Nat Rev Immunol 2009 9 15 27. doi: 10.1038/nri2454.
    • (2009) Nat Rev Immunol , vol.9 , pp. 15-27
    • Batista, F.D.1    Harwood, N.E.2
  • 25
    • 33644848385 scopus 로고    scopus 로고
    • Primary T cell expansion and differentiation in vivo requires antigen presentation by B cells
    • Crawford A, Macleod M, Schumacher T, Corlett L, Gray D, Primary T cell expansion and differentiation in vivo requires antigen presentation by B cells. J Immunol 2006 176 3498 3506
    • (2006) J Immunol , vol.176 , pp. 3498-3506
    • Crawford, A.1    Macleod, M.2    Schumacher, T.3    Corlett, L.4    Gray, D.5
  • 26
    • 84941773482 scopus 로고    scopus 로고
    • B Cell-specific MHC class II deletion reveals multiple nonredundant roles for B cell antigen presentation in murine lupus
    • Giles JR, Kashgarian M, Koni PA, Shlomchik MJ, B Cell-specific MHC class II deletion reveals multiple nonredundant roles for B cell antigen presentation in murine lupus. J Immunol 2015 195 2571 2579. doi: 10.4049/jimmunol.1500792.
    • (2015) J Immunol , vol.195 , pp. 2571-2579
    • Giles, J.R.1    Kashgarian, M.2    Koni, P.A.3    Shlomchik, M.J.4
  • 27
    • 84890819172 scopus 로고    scopus 로고
    • MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies
    • Molnarfi N, Schulze-Topphoff U, Weber MS, MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies. J Exp Med 2013 210 2921 2937. doi: 10.1084/jem.20130699.
    • (2013) J Exp Med , vol.210 , pp. 2921-2937
    • Molnarfi, N.1    Schulze-Topphoff, U.2    Weber, M.S.3
  • 28
    • 84906937004 scopus 로고    scopus 로고
    • The role of heat shock proteins in atherosclerosis
    • Wick G, Jakic B, Buszko M, Wick MC, Grundtman C, The role of heat shock proteins in atherosclerosis. Nat Rev Cardiol 2014 11 516 529. doi: 10.1038/nrcardio.2014.91.
    • (2014) Nat Rev Cardiol , vol.11 , pp. 516-529
    • Wick, G.1    Jakic, B.2    Buszko, M.3    Wick, M.C.4    Grundtman, C.5
  • 30
    • 0033958328 scopus 로고    scopus 로고
    • Oligoclonal T cell expansions in atherosclerotic lesions of apolipoprotein E-deficient mice
    • Paulsson G, Zhou X, Törnquist E, Hansson GK, Oligoclonal T cell expansions in atherosclerotic lesions of apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 2000 20 10 17
    • (2000) Arterioscler Thromb Vasc Biol , vol.20 , pp. 10-17
    • Paulsson, G.1    Zhou, X.2    Törnquist, E.3    Hansson, G.K.4
  • 32
    • 85017007569 scopus 로고    scopus 로고
    • Atheroprotective vaccination with MHC-II-restricted ApoB peptides induces peritoneal IL-10-producing CD4 T cells
    • Kimura T, Tse K, McArdle S, Atheroprotective vaccination with MHC-II-restricted ApoB peptides induces peritoneal IL-10-producing CD4 T cells. Am J Physiol Heart Circ Physiol 2017;4:H781-H790. doi: 10.1152/ajpheart.00798.2016.
    • (2017) Am J Physiol Heart Circ Physiol
    • Kimura, T.1    Tse, K.2    McArdle, S.3
  • 34
    • 0024416254 scopus 로고
    • Detection of activated T lymphocytes in the human atherosclerotic plaque
    • Hansson GK, Holm J, Jonasson L, Detection of activated T lymphocytes in the human atherosclerotic plaque. Am J Pathol 1989 135 169 175
    • (1989) Am J Pathol , vol.135 , pp. 169-175
    • Hansson, G.K.1    Holm, J.2    Jonasson, L.3
  • 35
    • 85012273600 scopus 로고    scopus 로고
    • A change in inflammatory footprint precedes plaque instability: A systematic evaluation of cellular aspects of the adaptive immune response in human atherosclerosis
    • van Dijk RA, Duinisveld AJ, Schaapherder AF, A change in inflammatory footprint precedes plaque instability: a systematic evaluation of cellular aspects of the adaptive immune response in human atherosclerosis. J Am Heart Assoc 2015 4
    • (2015) J Am Heart Assoc , vol.4
    • Van Dijk, R.A.1    Duinisveld, A.J.2    Schaapherder, A.F.3
  • 40
    • 0036124714 scopus 로고    scopus 로고
    • Interleukin-4 deficiency decreases atherosclerotic lesion formation in a site-specific manner in female LDL receptor-/- mice
    • King VL, Szilvassy SJ, Daugherty A, Interleukin-4 deficiency decreases atherosclerotic lesion formation in a site-specific manner in female LDL receptor-/- mice. Arterioscler Thromb Vasc Biol 2002 22 456 461
    • (2002) Arterioscler Thromb Vasc Biol , vol.22 , pp. 456-461
    • King, V.L.1    Szilvassy, S.J.2    Daugherty, A.3
  • 42
    • 0042926424 scopus 로고    scopus 로고
    • The role of interleukin-4 and interleukin-12 in the progression of atherosclerosis in apolipoprotein E-deficient mice
    • Davenport P, Tipping PG, The role of interleukin-4 and interleukin-12 in the progression of atherosclerosis in apolipoprotein E-deficient mice. Am J Pathol 2003 163 1117 1125. doi: 10.1016/S0002-9440(10)63471-2.
    • (2003) Am J Pathol , vol.163 , pp. 1117-1125
    • Davenport, P.1    Tipping, P.G.2
  • 44
    • 77951485998 scopus 로고    scopus 로고
    • Blockade of interleukin-17A results in reduced atherosclerosis in apolipoprotein E-deficient mice
    • Smith E, Prasad KM, Butcher M, Dobrian A, Kolls JK, Ley K, Galkina E, Blockade of interleukin-17A results in reduced atherosclerosis in apolipoprotein E-deficient mice. Circulation 2010 121 1746 1755. doi: 10.1161/CIRCULATIONAHA.109.924886.
    • (2010) Circulation , vol.121 , pp. 1746-1755
    • Smith, E.1    Prasad, K.M.2    Butcher, M.3    Dobrian, A.4    Kolls, J.K.5    Ley, K.6    Galkina, E.7
  • 47
    • 82755198003 scopus 로고    scopus 로고
    • Regulatory T cell lineage commitment in the thymus
    • Klein L, Jovanovic K, Regulatory T cell lineage commitment in the thymus. Semin Immunol 2011 23 401 409. doi: 10.1016/j.smim.2011.06.003.
    • (2011) Semin Immunol , vol.23 , pp. 401-409
    • Klein, L.1    Jovanovic, K.2
  • 48
    • 84901487911 scopus 로고    scopus 로고
    • Positive and negative selection of the T cell repertoire: What thymocytes see (and don't see)
    • Klein L, Kyewski B, Allen PM, Hogquist KA, Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see). Nat Rev Immunol 2014 14 377 391. doi: 10.1038/nri3667.
    • (2014) Nat Rev Immunol , vol.14 , pp. 377-391
    • Klein, L.1    Kyewski, B.2    Allen, P.M.3    Hogquist, K.A.4
  • 49
    • 0348223787 scopus 로고    scopus 로고
    • Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
    • Chen W, Jin W, Hardegen N, Lei KJ, Li L, Marinos N, McGrady G, Wahl SM, Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 2003 198 1875 1886. doi: 10.1084/jem.20030152.
    • (2003) J Exp Med , vol.198 , pp. 1875-1886
    • Chen, W.1    Jin, W.2    Hardegen, N.3    Lei, K.J.4    Li, L.5    Marinos, N.6    McGrady, G.7    Wahl, S.M.8
  • 50
    • 84957434158 scopus 로고    scopus 로고
    • Regulatory T cells in atherosclerosis: Critical immune regulatory function and therapeutic potential
    • Spitz C, Winkels H, Bürger C, Weber C, Lutgens E, Hansson GK, Gerdes N, Regulatory T cells in atherosclerosis: critical immune regulatory function and therapeutic potential. Cell Mol Life Sci 2016 73 901 922. doi: 10.1007/s00018-015-2080-2.
    • (2016) Cell Mol Life Sci , vol.73 , pp. 901-922
    • Spitz, C.1    Winkels, H.2    Bürger, C.3    Weber, C.4    Lutgens, E.5    Hansson, G.K.6    Gerdes, N.7
  • 54
    • 84874597449 scopus 로고    scopus 로고
    • Depletion of FOXP3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis
    • Klingenberg R, Gerdes N, Badeau RM, Depletion of FOXP3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis. J Clin Invest 2013 123 1323 1334. doi: 10.1172/JCI63891.
    • (2013) J Clin Invest , vol.123 , pp. 1323-1334
    • Klingenberg, R.1    Gerdes, N.2    Badeau, R.M.3
  • 55
    • 79960410419 scopus 로고    scopus 로고
    • Dynamic changes in regulatory T cells are linked to levels of diet-induced hypercholesterolemia
    • Maganto-García E, Tarrio ML, Grabie N, Bu DX, Lichtman AH, Dynamic changes in regulatory T cells are linked to levels of diet-induced hypercholesterolemia. Circulation 2011 124 185 195. doi: 10.1161/CIRCULATIONAHA.110.006411.
    • (2011) Circulation , vol.124 , pp. 185-195
    • Maganto-García, E.1    Tarrio, M.L.2    Grabie, N.3    Bu, D.X.4    Lichtman, A.H.5
  • 57
    • 84968879602 scopus 로고    scopus 로고
    • Regulatory T-cell plasticity: Another layer of complexity in atherosclerosis
    • Ait-Oufella H, Tedgui A, Regulatory T-cell plasticity: another layer of complexity in atherosclerosis. Circ Res 2016 118 1461 1463. doi: 10.1161/CIRCRESAHA.116.308805.
    • (2016) Circ Res , vol.118 , pp. 1461-1463
    • Ait-Oufella, H.1    Tedgui, A.2
  • 58
    • 84994910673 scopus 로고    scopus 로고
    • Foxp3+CD4+ regulatory T-cell subtypes and atherosclerosis
    • Kyaw T, Toh BH, Bobik A, Foxp3+CD4+ regulatory T-cell subtypes and atherosclerosis. Circ Res 2016 119 1151 1153. doi: 10.1161/CIRCRESAHA.116.309999.
    • (2016) Circ Res , vol.119 , pp. 1151-1153
    • Kyaw, T.1    Toh, B.H.2    Bobik, A.3
  • 59
    • 0030057218 scopus 로고    scopus 로고
    • T cell activation determined by T cell receptor number and tunable thresholds
    • Viola A, Lanzavecchia A, T cell activation determined by T cell receptor number and tunable thresholds. Science 1996 273 104 106
    • (1996) Science , vol.273 , pp. 104-106
    • Viola, A.1    Lanzavecchia, A.2
  • 60
    • 1342303482 scopus 로고    scopus 로고
    • Of mice and not men: Differences between mouse and human immunology
    • Mestas J, Hughes CC, Of mice and not men: differences between mouse and human immunology. J Immunol 2004 172 2731 2738
    • (2004) J Immunol , vol.172 , pp. 2731-2738
    • Mestas, J.1    Hughes, C.C.2
  • 61
    • 84938488008 scopus 로고    scopus 로고
    • Co-stimulatory blockade of the CD28/CD80-86/CTLA-4 balance in transplantation: Impact on memory T cells?
    • Ville S, Poirier N, Blancho G, Vanhove B, Co-stimulatory blockade of the CD28/CD80-86/CTLA-4 balance in transplantation: impact on memory T cells? Front Immunol 2015 6 411. doi: 10.3389/fimmu.2015.00411.
    • (2015) Front Immunol , vol.6 , pp. 411
    • Ville, S.1    Poirier, N.2    Blancho, G.3    Vanhove, B.4
  • 62
  • 63
    • 0034823168 scopus 로고    scopus 로고
    • Signaling through CD28 and CTLA-4 controls two distinct forms of T cell anergy
    • Wells AD, Walsh MC, Bluestone JA, Turka LA, Signaling through CD28 and CTLA-4 controls two distinct forms of T cell anergy. J Clin Invest 2001 108 895 903. doi: 10.1172/JCI13220.
    • (2001) J Clin Invest , vol.108 , pp. 895-903
    • Wells, A.D.1    Walsh, M.C.2    Bluestone, J.A.3    Turka, L.A.4
  • 65
    • 34548488466 scopus 로고    scopus 로고
    • Manipulation of regulatory T-cell number and function with CD28-specific monoclonal antibodies
    • Hünig T, Manipulation of regulatory T-cell number and function with CD28-specific monoclonal antibodies. Adv Immunol 2007 95 111 148. doi: 10.1016/S0065-2776(07)95004-X.
    • (2007) Adv Immunol , vol.95 , pp. 111-148
    • Hünig, T.1
  • 66
    • 35048850411 scopus 로고    scopus 로고
    • Monocyte-derived dendritic cells of patients with coronary artery disease show an increased expression of costimulatory molecules CD40, CD80 and CD86 in vitro
    • Dopheide JF, Sester U, Schlitt A, Horstick G, Rupprecht HJ, Münzel T, Blankenberg S, Monocyte-derived dendritic cells of patients with coronary artery disease show an increased expression of costimulatory molecules CD40, CD80 and CD86 in vitro. Coron Artery Dis 2007 18 523 531. doi: 10.1097/MCA.0b013e3282eff1ad.
    • (2007) Coron Artery Dis , vol.18 , pp. 523-531
    • Dopheide, J.F.1    Sester, U.2    Schlitt, A.3    Horstick, G.4    Rupprecht, H.J.5    Münzel, T.6    Blankenberg, S.7
  • 67
    • 0030848708 scopus 로고    scopus 로고
    • Costimulatory molecules in human atherosclerotic plaques: An indication of antigen specific T lymphocyte activation
    • de Boer OJ, Hirsch F, van der Wal AC, van der Loos CM, Das PK, Becker AE, Costimulatory molecules in human atherosclerotic plaques: an indication of antigen specific T lymphocyte activation. Atherosclerosis 1997 133 227 234
    • (1997) Atherosclerosis , vol.133 , pp. 227-234
    • De Boer, O.J.1    Hirsch, F.2    Van Der Wal, A.C.3    Van Der Loos, C.M.4    Das, P.K.5    Becker, A.E.6
  • 69
    • 2142817119 scopus 로고    scopus 로고
    • B7-1/B7-2 costimulation regulates plaque antigen-specific T-cell responses and atherogenesis in low-density lipoprotein receptor-deficient mice
    • Buono C, Pang H, Uchida Y, Libby P, Sharpe AH, Lichtman AH, B7-1/B7-2 costimulation regulates plaque antigen-specific T-cell responses and atherogenesis in low-density lipoprotein receptor-deficient mice. Circulation 2004 109 2009 2015. doi: 10.1161/01.CIR.0000127121.16815.F1.
    • (2004) Circulation , vol.109 , pp. 2009-2015
    • Buono, C.1    Pang, H.2    Uchida, Y.3    Libby, P.4    Sharpe, A.H.5    Lichtman, A.H.6
  • 76
    • 81755172883 scopus 로고    scopus 로고
    • CD83-stimulated monocytes suppress T-cell immune responses through production of prostaglandin E2
    • Chen L, Zhu Y, Zhang G, Gao C, Zhong W, Zhang X, CD83-stimulated monocytes suppress T-cell immune responses through production of prostaglandin E2. Proc Natl Acad Sci U S A 2011 108 18778 18783. doi: 10.1073/pnas.1018994108.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 18778-18783
    • Chen, L.1    Zhu, Y.2    Zhang, G.3    Gao, C.4    Zhong, W.5    Zhang, X.6
  • 80
    • 0027379443 scopus 로고
    • Role of CD40-CD40-ligand interaction in Ig-isotype switching
    • Fuleihan R, Ramesh N, Geha RS, Role of CD40-CD40-ligand interaction in Ig-isotype switching. Curr Opin Immunol 1993 5 963 967
    • (1993) Curr Opin Immunol , vol.5 , pp. 963-967
    • Fuleihan, R.1    Ramesh, N.2    Geha, R.S.3
  • 83
    • 0029812593 scopus 로고    scopus 로고
    • Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation
    • Cella M, Scheidegger D, Palmer-Lehmann K, Lane P, Lanzavecchia A, Alber G, Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J Exp Med 1996 184 747 752
    • (1996) J Exp Med , vol.184 , pp. 747-752
    • Cella, M.1    Scheidegger, D.2    Palmer-Lehmann, K.3    Lane, P.4    Lanzavecchia, A.5    Alber, G.6
  • 84
    • 70349141664 scopus 로고    scopus 로고
    • Macrophage CD40 signaling: A pivotal regulator of disease protection and pathogenesis
    • Suttles J, Stout RD, Macrophage CD40 signaling: a pivotal regulator of disease protection and pathogenesis. Semin Immunol 2009 21 257 264. doi: 10.1016/j.smim.2009.05.011.
    • (2009) Semin Immunol , vol.21 , pp. 257-264
    • Suttles, J.1    Stout, R.D.2
  • 85
    • 0028858649 scopus 로고
    • Stimulation of CD40 with purified soluble gp39 induces proinflammatory responses in human monocytes
    • Kiener PA, Moran-Davis P, Rankin BM, Wahl AF, Aruffo A, Hollenbaugh D, Stimulation of CD40 with purified soluble gp39 induces proinflammatory responses in human monocytes. J Immunol 1995 155 4917 4925
    • (1995) J Immunol , vol.155 , pp. 4917-4925
    • Kiener, P.A.1    Moran-Davis, P.2    Rankin, B.M.3    Wahl, A.F.4    Aruffo, A.5    Hollenbaugh, D.6
  • 86
    • 0035052821 scopus 로고    scopus 로고
    • Human lung tissue macrophages, but not alveolar macrophages, express matrix metalloproteinases after direct contact with activated T lymphocytes
    • Ferrari-Lacraz S, Nicod LP, Chicheportiche R, Welgus HG, Dayer JM, Human lung tissue macrophages, but not alveolar macrophages, express matrix metalloproteinases after direct contact with activated T lymphocytes. Am J Respir Cell Mol Biol 2001 24 442 451. doi: 10.1165/ajrcmb.24.4.4008.
    • (2001) Am J Respir Cell Mol Biol , vol.24 , pp. 442-451
    • Ferrari-Lacraz, S.1    Nicod, L.P.2    Chicheportiche, R.3    Welgus, H.G.4    Dayer, J.M.5
  • 87
    • 0037144612 scopus 로고    scopus 로고
    • A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory
    • Bourgeois C, Rocha B, Tanchot C, A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory. Science 2002 297 2060 2063. doi: 10.1126/science.1072615.
    • (2002) Science , vol.297 , pp. 2060-2063
    • Bourgeois, C.1    Rocha, B.2    Tanchot, C.3
  • 88
    • 33846234751 scopus 로고    scopus 로고
    • A costimulatory function for T cell CD40
    • Munroe ME, Bishop GA, A costimulatory function for T cell CD40. J Immunol 2007 178 671 682
    • (2007) J Immunol , vol.178 , pp. 671-682
    • Munroe, M.E.1    Bishop, G.A.2
  • 89
    • 11844265969 scopus 로고    scopus 로고
    • Induction of CD70 on dendritic cells through CD40 or TLR stimulation contributes to the development of CD8+ T cell responses in the absence of CD4+ T cells
    • Bullock TN, Yagita H, Induction of CD70 on dendritic cells through CD40 or TLR stimulation contributes to the development of CD8+ T cell responses in the absence of CD4+ T cells. J Immunol 2005 174 710 717
    • (2005) J Immunol , vol.174 , pp. 710-717
    • Bullock, T.N.1    Yagita, H.2
  • 90
    • 79952333094 scopus 로고    scopus 로고
    • The CD40 gene polymorphism rs1883832 is associated with risk of acute coronary syndrome in a Chinese case-control study
    • Wang M, Li Y, Li W, Xia ZE, Wu Q, The CD40 gene polymorphism rs1883832 is associated with risk of acute coronary syndrome in a Chinese case-control study. DNA Cell Biol 2011 30 173 178. doi: 10.1089/dna.2010.1129.
    • (2011) DNA Cell Biol , vol.30 , pp. 173-178
    • Wang, M.1    Li, Y.2    Li, W.3    Xia, Z.E.4    Wu, Q.5
  • 91
    • 84883806740 scopus 로고    scopus 로고
    • Single nucleotide polymorphism of CD40 in the 5'-untranslated region is associated with ischemic stroke
    • Ma Y, Wang SX, Liu Y, Peng GG, Wang XM, Zhang B, Wu BH, Yu JM, Single nucleotide polymorphism of CD40 in the 5'-untranslated region is associated with ischemic stroke. Gene 2013 529 257 261. doi: 10.1016/j.gene.2013.07.086.
    • (2013) Gene , vol.529 , pp. 257-261
    • Ma, Y.1    Wang, S.X.2    Liu, Y.3    Peng, G.G.4    Wang, X.M.5    Zhang, B.6    Wu, B.H.7    Yu, J.M.8
  • 92
    • 84971441736 scopus 로고    scopus 로고
    • Genetic variants of CD40 gene are associated with coronary artery disease and blood lipid levels
    • Zhou L, Xie L, Zheng D, Li N, Zhu J, Wang S, Li B, Ye L, Genetic variants of CD40 gene are associated with coronary artery disease and blood lipid levels. Biomed Res Int 2016 2016 1693619. doi: 10.1155/2016/1693619.
    • (2016) Biomed Res Int , vol.2016 , pp. 1693619
    • Zhou, L.1    Xie, L.2    Zheng, D.3    Li, N.4    Zhu, J.5    Wang, S.6    Li, B.7    Ye, L.8
  • 95
    • 2642608661 scopus 로고    scopus 로고
    • Reduction of atherosclerosis in mice by inhibition of CD40 signalling
    • Mach F, Schönbeck U, Sukhova GK, Atkinson E, Libby P, Reduction of atherosclerosis in mice by inhibition of CD40 signalling. Nature 1998 394 200 203. doi: 10.1038/28204.
    • (1998) Nature , vol.394 , pp. 200-203
    • Mach, F.1    Schönbeck, U.2    Sukhova, G.K.3    Atkinson, E.4    Libby, P.5
  • 96
  • 98
    • 78549272749 scopus 로고    scopus 로고
    • Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis
    • Lievens D, Zernecke A, Seijkens T, Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis. Blood 2010 116 4317 4327. doi: 10.1182/blood-2010-01-261206.
    • (2010) Blood , vol.116 , pp. 4317-4327
    • Lievens, D.1    Zernecke, A.2    Seijkens, T.3
  • 102
    • 34247527793 scopus 로고    scopus 로고
    • CD40 ligand mediates inflammation independently of CD40 by interaction with Mac-1
    • Zirlik A, Maier C, Gerdes N, CD40 ligand mediates inflammation independently of CD40 by interaction with Mac-1. Circulation 2007 115 1571 1580. doi: 10.1161/CIRCULATIONAHA.106.683201.
    • (2007) Circulation , vol.115 , pp. 1571-1580
    • Zirlik, A.1    Maier, C.2    Gerdes, N.3
  • 103
    • 77149136451 scopus 로고    scopus 로고
    • Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile
    • Lutgens E, Lievens D, Beckers L, Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile. J Exp Med 2010 207 391 404. doi: 10.1084/jem.20091293.
    • (2010) J Exp Med , vol.207 , pp. 391-404
    • Lutgens, E.1    Lievens, D.2    Beckers, L.3
  • 104
    • 84978079848 scopus 로고    scopus 로고
    • Do the Apoe-/- and Ldlr-/- Mice Yield the Same Insight on Atherogenesis?
    • Getz GS, Reardon CA, Do the Apoe-/- and Ldlr-/- Mice Yield the Same Insight on Atherogenesis? Arterioscler Thromb Vasc Biol 2016 36 1734 1741. doi: 10.1161/ATVBAHA.116.306874.
    • (2016) Arterioscler Thromb Vasc Biol , vol.36 , pp. 1734-1741
    • Getz, G.S.1    Reardon, C.A.2
  • 105
    • 85007449433 scopus 로고    scopus 로고
    • Applications and limitations of mouse models for understanding human atherosclerosis
    • von Scheidt M, Zhao Y, Kurt Z, Pan C, Zeng L, Yang X, Schunkert H, Lusis AJ, Applications and limitations of mouse models for understanding human atherosclerosis. Cell Metab 2017 25 248 261. doi: 10.1016/j.cmet.2016.11.001.
    • (2017) Cell Metab , vol.25 , pp. 248-261
    • Von Scheidt, M.1    Zhao, Y.2    Kurt, Z.3    Pan, C.4    Zeng, L.5    Yang, X.6    Schunkert, H.7    Lusis, A.J.8
  • 106
    • 18844364782 scopus 로고    scopus 로고
    • CD27 and CD70 in T cell and B cell activation
    • Borst J, Hendriks J, Xiao Y, CD27 and CD70 in T cell and B cell activation. Curr Opin Immunol 2005 17 275 281. doi: 10.1016/j.coi.2005.04.004.
    • (2005) Curr Opin Immunol , vol.17 , pp. 275-281
    • Borst, J.1    Hendriks, J.2    Xiao, Y.3
  • 107
    • 65349144269 scopus 로고    scopus 로고
    • Timing and tuning of CD27-CD70 interactions: The impact of signal strength in setting the balance between adaptive responses and immunopathology
    • Nolte MA, van Olffen RW, van Gisbergen KP, van Lier RA, Timing and tuning of CD27-CD70 interactions: the impact of signal strength in setting the balance between adaptive responses and immunopathology. Immunol Rev 2009 229 216 231. doi: 10.1111/j.1600-065X.2009.00774.x.
    • (2009) Immunol Rev , vol.229 , pp. 216-231
    • Nolte, M.A.1    Van Olffen, R.W.2    Van Gisbergen, K.P.3    Van Lier, R.A.4
  • 108
    • 22544437564 scopus 로고    scopus 로고
    • During viral infection of the respiratory tract, CD27, 4-1BB, and OX40 collectively determine formation of CD8+ memory T cells and their capacity for secondary expansion
    • Hendriks J, Xiao Y, Rossen JW, van der Sluijs KF, Sugamura K, Ishii N, Borst J, During viral infection of the respiratory tract, CD27, 4-1BB, and OX40 collectively determine formation of CD8+ memory T cells and their capacity for secondary expansion. J Immunol 2005 175 1665 1676
    • (2005) J Immunol , vol.175 , pp. 1665-1676
    • Hendriks, J.1    Xiao, Y.2    Rossen, J.W.3    Van Der Sluijs, K.F.4    Sugamura, K.5    Ishii, N.6    Borst, J.7
  • 111
    • 22144492636 scopus 로고    scopus 로고
    • CD70+ antigen-presenting cells control the proliferation and differentiation of T cells in the intestinal mucosa
    • Laouar A, Haridas V, Vargas D, Zhinan X, Chaplin D, van Lier RA, Manjunath N, CD70+ antigen-presenting cells control the proliferation and differentiation of T cells in the intestinal mucosa. Nat Immunol 2005 6 698 706. doi: 10.1038/ni1212.
    • (2005) Nat Immunol , vol.6 , pp. 698-706
    • Laouar, A.1    Haridas, V.2    Vargas, D.3    Zhinan, X.4    Chaplin, D.5    Van Lier, R.A.6    Manjunath, N.7
  • 114
    • 2942586926 scopus 로고    scopus 로고
    • CD27 is acquired by primed B cells at the centroblast stage and promotes germinal center formation
    • Xiao Y, Hendriks J, Langerak P, Jacobs H, Borst J, CD27 is acquired by primed B cells at the centroblast stage and promotes germinal center formation. J Immunol 2004 172 7432 7441
    • (2004) J Immunol , vol.172 , pp. 7432-7441
    • Xiao, Y.1    Hendriks, J.2    Langerak, P.3    Jacobs, H.4    Borst, J.5
  • 115
    • 0031571786 scopus 로고    scopus 로고
    • CD154/CD40 and CD70/CD27 interactions have different and sequential functions in T cell-dependent B cell responses: Enhancement of plasma cell differentiation by CD27 signaling
    • Jacquot S, Kobata T, Iwata S, Morimoto C, Schlossman SF, CD154/CD40 and CD70/CD27 interactions have different and sequential functions in T cell-dependent B cell responses: enhancement of plasma cell differentiation by CD27 signaling. J Immunol 1997 159 2652 2657
    • (1997) J Immunol , vol.159 , pp. 2652-2657
    • Jacquot, S.1    Kobata, T.2    Iwata, S.3    Morimoto, C.4    Schlossman, S.F.5
  • 120
    • 84941188919 scopus 로고    scopus 로고
    • Novel mutations in TNFRSF7/CD27: Clinical, immunologic, and genetic characterization of human CD27 deficiency
    • Alkhairy OK, Perez-Becker R, Driessen GJ, Novel mutations in TNFRSF7/CD27: Clinical, immunologic, and genetic characterization of human CD27 deficiency. J Allergy Clin Immunol 2015 136 703 712.e10. doi: 10.1016/j.jaci.2015.02.022.
    • (2015) J Allergy Clin Immunol , vol.136 , pp. 703-703e10
    • Alkhairy, O.K.1    Perez-Becker, R.2    Driessen, G.J.3
  • 123
    • 0242611000 scopus 로고    scopus 로고
    • CD27 promotes survival of activated T cells and complements CD28 in generation and establishment of the effector T cell pool
    • Hendriks J, Xiao Y, Borst J, CD27 promotes survival of activated T cells and complements CD28 in generation and establishment of the effector T cell pool. J Exp Med 2003 198 1369 1380. doi: 10.1084/jem.20030916.
    • (2003) J Exp Med , vol.198 , pp. 1369-1380
    • Hendriks, J.1    Xiao, Y.2    Borst, J.3
  • 125
    • 74949120423 scopus 로고    scopus 로고
    • CD27 sustains survival of CTLs in virus-infected nonlymphoid tissue in mice by inducing autocrine IL-2 production
    • Peperzak V, Xiao Y, Veraar EA, Borst J, CD27 sustains survival of CTLs in virus-infected nonlymphoid tissue in mice by inducing autocrine IL-2 production. J Clin Invest 2010 120 168 178. doi: 10.1172/JCI40178.
    • (2010) J Clin Invest , vol.120 , pp. 168-178
    • Peperzak, V.1    Xiao, Y.2    Veraar, E.A.3    Borst, J.4
  • 129
    • 85007289636 scopus 로고    scopus 로고
    • CD70 limits atherosclerosis and promotes macrophage function
    • Winkels H, Meiler S, Smeets E, CD70 limits atherosclerosis and promotes macrophage function. Thromb Haemost 2017 117 164 175. doi: 10.1160/TH16-04-0318.
    • (2017) Thromb Haemost , vol.117 , pp. 164-175
    • Winkels, H.1    Meiler, S.2    Smeets, E.3
  • 130
    • 84961393230 scopus 로고    scopus 로고
    • CD70 exacerbates blood pressure elevation and renal damage in response to repeated hypertensive stimuli
    • Itani HA, Xiao L, Saleh MA, CD70 exacerbates blood pressure elevation and renal damage in response to repeated hypertensive stimuli. Circ Res 2016 118 1233 1243. doi: 10.1161/CIRCRESAHA.115.308111.
    • (2016) Circ Res , vol.118 , pp. 1233-1243
    • Itani, H.A.1    Xiao, L.2    Saleh, M.A.3
  • 131
    • 0036170938 scopus 로고    scopus 로고
    • Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance
    • Shimizu J, Yamazaki S, Takahashi T, Ishida Y, Sakaguchi S, Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol 2002 3 135 142. doi: 10.1038/ni759.
    • (2002) Nat Immunol , vol.3 , pp. 135-142
    • Shimizu, J.1    Yamazaki, S.2    Takahashi, T.3    Ishida, Y.4    Sakaguchi, S.5
  • 133
    • 33746575650 scopus 로고    scopus 로고
    • The GITR-GITRL interaction: Co-stimulation or contrasuppression of regulatory activity?
    • Shevach EM, Stephens GL, The GITR-GITRL interaction: co-stimulation or contrasuppression of regulatory activity? Nat Rev Immunol 2006 6 613 618. doi: 10.1038/nri1867.
    • (2006) Nat Rev Immunol , vol.6 , pp. 613-618
    • Shevach, E.M.1    Stephens, G.L.2
  • 134
    • 78349278492 scopus 로고    scopus 로고
    • Glucocorticoid-induced TNFR-related (GITR) protein and its ligand in antitumor immunity: Functional role and therapeutic modulation
    • Placke T, Kopp HG, Salih HR, Glucocorticoid-induced TNFR-related (GITR) protein and its ligand in antitumor immunity: functional role and therapeutic modulation. Clin Dev Immunol 2010 2010 239083. doi: 10.1155/2010/239083.
    • (2010) Clin Dev Immunol , vol.2010 , pp. 239083
    • Placke, T.1    Kopp, H.G.2    Salih, H.R.3
  • 135
    • 0033602151 scopus 로고    scopus 로고
    • Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR
    • Gurney AL, Marsters SA, Huang RM, Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR. Curr Biol 1999 9 215 218
    • (1999) Curr Biol , vol.9 , pp. 215-218
    • Gurney, A.L.1    Marsters, S.A.2    Huang, R.M.3
  • 136
    • 0033525904 scopus 로고    scopus 로고
    • Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand
    • Kwon B, Yu KY, Ni J, Yu GL, Jang IK, Kim YJ, Xing L, Liu D, Wang SX, Kwon BS, Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand. J Biol Chem 1999 274 6056 6061
    • (1999) J Biol Chem , vol.274 , pp. 6056-6061
    • Kwon, B.1    Yu, K.Y.2    Ni, J.3    Yu, G.L.4    Jang, I.K.5    Kim, Y.J.6    Xing, L.7    Liu, D.8    Wang, S.X.9    Kwon, B.S.10
  • 137
    • 33749983724 scopus 로고    scopus 로고
    • Glucocorticoid-induced tumour necrosis factor receptor family related protein (GITR) mediates inflammatory activation of macrophages that can destabilize atherosclerotic plaques
    • Kim WJ, Bae EM, Kang YJ, Bae HU, Hong SH, Lee JY, Park JE, Kwon BS, Suk K, Lee WH, Glucocorticoid-induced tumour necrosis factor receptor family related protein (GITR) mediates inflammatory activation of macrophages that can destabilize atherosclerotic plaques. Immunology 2006 119 421 429. doi: 10.1111/j.1365-2567.2006.02453.x.
    • (2006) Immunology , vol.119 , pp. 421-429
    • Kim, W.J.1    Bae, E.M.2    Kang, Y.J.3    Bae, H.U.4    Hong, S.H.5    Lee, J.Y.6    Park, J.E.7    Kwon, B.S.8    Suk, K.9    Lee, W.H.10
  • 139
    • 84899050190 scopus 로고    scopus 로고
    • Cell-specific and context-dependent effects of GITR in cancer, autoimmunity, and infection
    • Clouthier DL, Watts TH, Cell-specific and context-dependent effects of GITR in cancer, autoimmunity, and infection. Cytokine Growth Factor Rev 2014 25 91 106. doi: 10.1016/j.cytogfr.2013.12.003.
    • (2014) Cytokine Growth Factor Rev , vol.25 , pp. 91-106
    • Clouthier, D.L.1    Watts, T.H.2
  • 140
    • 65349112520 scopus 로고    scopus 로고
    • The significance of OX40 and OX40L to T-cell biology and immune disease
    • Croft M, So T, Duan W, Soroosh P, The significance of OX40 and OX40L to T-cell biology and immune disease. Immunol Rev 2009 229 173 191. doi: 10.1111/j.1600-065X.2009.00766.x.
    • (2009) Immunol Rev , vol.229 , pp. 173-191
    • Croft, M.1    So, T.2    Duan, W.3    Soroosh, P.4
  • 141
    • 19344374856 scopus 로고    scopus 로고
    • Sustained survivin expression from OX40 costimulatory signals drives T cell clonal expansion
    • Song J, So T, Cheng M, Tang X, Croft M, Sustained survivin expression from OX40 costimulatory signals drives T cell clonal expansion. Immunity 2005 22 621 631. doi: 10.1016/j.immuni.2005.03.012.
    • (2005) Immunity , vol.22 , pp. 621-631
    • Song, J.1    So, T.2    Cheng, M.3    Tang, X.4    Croft, M.5
  • 143
    • 34948883517 scopus 로고    scopus 로고
    • OX40 costimulation turns off Foxp3+ Tregs
    • Vu MD, Xiao X, Gao W, OX40 costimulation turns off Foxp3+ Tregs. Blood 2007 110 2501 2510
    • (2007) Blood , vol.110 , pp. 2501-2510
    • Vu, M.D.1    Xiao, X.2    Gao, W.3
  • 144
    • 0029938992 scopus 로고    scopus 로고
    • The T cell-B cell interaction via OX40-OX40L is necessary for the T cell-dependent humoral immune response
    • Stüber E, Strober W, The T cell-B cell interaction via OX40-OX40L is necessary for the T cell-dependent humoral immune response. J Exp Med 1996 183 979 989
    • (1996) J Exp Med , vol.183 , pp. 979-989
    • Stüber, E.1    Strober, W.2
  • 145
    • 78049524659 scopus 로고    scopus 로고
    • OX40 ligand regulates inflammation and mortality in the innate immune response to sepsis
    • Karulf M, Kelly A, Weinberg AD, Gold JA, OX40 ligand regulates inflammation and mortality in the innate immune response to sepsis. J Immunol 2010 185 4856 4862. doi: 10.4049/jimmunol.1000404.
    • (2010) J Immunol , vol.185 , pp. 4856-4862
    • Karulf, M.1    Kelly, A.2    Weinberg, A.D.3    Gold, J.A.4
  • 146
    • 20144386616 scopus 로고    scopus 로고
    • Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility
    • Wang X, Ria M, Kelmenson PM, Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility. Nat Genet 2005 37 365 372. doi: 10.1038/ng1524.
    • (2005) Nat Genet , vol.37 , pp. 365-372
    • Wang, X.1    Ria, M.2    Kelmenson, P.M.3
  • 149
    • 33847688373 scopus 로고    scopus 로고
    • Interruption of the Tnfrsf4/Tnfsf4 (OX40/OX40L) pathway attenuates atherogenesis in low-density lipoprotein receptor-deficient mice
    • van Wanrooij EJ, van Puijvelde GH, de Vos P, Yagita H, van Berkel TJ, Kuiper J, Interruption of the Tnfrsf4/Tnfsf4 (OX40/OX40L) pathway attenuates atherogenesis in low-density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol 2007 27 204 210. doi: 10.1161/01.ATV.0000251007.07648.81.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 204-210
    • Van Wanrooij, E.J.1    Van Puijvelde, G.H.2    De Vos, P.3    Yagita, H.4    Van Berkel, T.J.5    Kuiper, J.6
  • 151
    • 33646559241 scopus 로고    scopus 로고
    • Deciphering CD30 ligand biology and its role in humoral immunity
    • Kennedy MK, Willis CR, Armitage RJ, Deciphering CD30 ligand biology and its role in humoral immunity. Immunology 2006 118 143 152. doi: 10.1111/j.1365-2567.2006.02354.x.
    • (2006) Immunology , vol.118 , pp. 143-152
    • Kennedy, M.K.1    Willis, C.R.2    Armitage, R.J.3
  • 152
    • 0040084598 scopus 로고    scopus 로고
    • CD30/TNF receptor-associated factor interaction: NF-kappa B activation and binding specificity
    • Lee SY, Lee SY, Kandala G, Liou ML, Liou HC, Choi Y, CD30/TNF receptor-associated factor interaction: NF-kappa B activation and binding specificity. Proc Natl Acad Sci U S A 1996 93 9699 9703
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 9699-9703
    • Lee, S.Y.1    Lee, S.Y.2    Kandala, G.3    Liou, M.L.4    Liou, H.C.5    Choi, Y.6
  • 153
    • 15444378040 scopus 로고    scopus 로고
    • Mice deficient in OX40 and CD30 signals lack memory antibody responses because of deficient CD4 T cell memory
    • Gaspal FM, Kim MY, McConnell FM, Raykundalia C, Bekiaris V, Lane PJ, Mice deficient in OX40 and CD30 signals lack memory antibody responses because of deficient CD4 T cell memory. J Immunol 2005 174 3891 3896
    • (2005) J Immunol , vol.174 , pp. 3891-3896
    • Gaspal, F.M.1    Kim, M.Y.2    McConnell, F.M.3    Raykundalia, C.4    Bekiaris, V.5    Lane, P.J.6
  • 156
    • 63149163677 scopus 로고    scopus 로고
    • The role of TNF superfamily members in T-cell function and diseases
    • Croft M, The role of TNF superfamily members in T-cell function and diseases. Nat Rev Immunol 2009 9 271 285. doi: 10.1038/nri2526.
    • (2009) Nat Rev Immunol , vol.9 , pp. 271-285
    • Croft, M.1
  • 158
    • 4644245852 scopus 로고    scopus 로고
    • CD137-deficient mice have reduced NK/NKT cell numbers and function, are resistant to lipopolysaccharide-induced shock syndromes, and have lower IL-4 responses
    • Vinay DS, Choi BK, Bae JS, Kim WY, Gebhardt BM, Kwon BS, CD137-deficient mice have reduced NK/NKT cell numbers and function, are resistant to lipopolysaccharide-induced shock syndromes, and have lower IL-4 responses. J Immunol 2004 173 4218 4229
    • (2004) J Immunol , vol.173 , pp. 4218-4229
    • Vinay, D.S.1    Choi, B.K.2    Bae, J.S.3    Kim, W.Y.4    Gebhardt, B.M.5    Kwon, B.S.6
  • 159
    • 47849100724 scopus 로고    scopus 로고
    • Identification of regulatory functions for 4-1BB and 4-1BBL in myelopoiesis and the development of dendritic cells
    • Lee SW, Park Y, So T, Kwon BS, Cheroutre H, Mittler RS, Croft M, Identification of regulatory functions for 4-1BB and 4-1BBL in myelopoiesis and the development of dendritic cells. Nat Immunol 2008 9 917 926. doi: 10.1038/ni.1632.
    • (2008) Nat Immunol , vol.9 , pp. 917-926
    • Lee, S.W.1    Park, Y.2    So, T.3    Kwon, B.S.4    Cheroutre, H.5    Mittler, R.S.6    Croft, M.7
  • 161
    • 77951042495 scopus 로고    scopus 로고
    • CD137 ligand mediates opposite effects in human and mouse NK cells and impairs NK-cell reactivity against human acute myeloid leukemia cells
    • Baessler T, Charton JE, Schmiedel BJ, Grünebach F, Krusch M, Wacker A, Rammensee HG, Salih HR, CD137 ligand mediates opposite effects in human and mouse NK cells and impairs NK-cell reactivity against human acute myeloid leukemia cells. Blood 2010 115 3058 3069. doi: 10.1182/blood-2009-06-227934.
    • (2010) Blood , vol.115 , pp. 3058-3069
    • Baessler, T.1    Charton, J.E.2    Schmiedel, B.J.3    Grünebach, F.4    Krusch, M.5    Wacker, A.6    Rammensee, H.G.7    Salih, H.R.8
  • 162
    • 18944375012 scopus 로고    scopus 로고
    • Enhanced CD4 T cell responsiveness in the absence of 4-1BB
    • Lee SW, Vella AT, Kwon BS, Croft M, Enhanced CD4 T cell responsiveness in the absence of 4-1BB. J Immunol 2005 174 6803 6808
    • (2005) J Immunol , vol.174 , pp. 6803-6808
    • Lee, S.W.1    Vella, A.T.2    Kwon, B.S.3    Croft, M.4
  • 164
    • 77949352851 scopus 로고    scopus 로고
    • CD137 (4-1BB) deficiency reduces atherosclerosis in hyperlipidemic mice
    • Jeon HJ, Choi JH, Jung IH, CD137 (4-1BB) deficiency reduces atherosclerosis in hyperlipidemic mice. Circulation 2010 121 1124 1133. doi: 10.1161/CIRCULATIONAHA.109.882704.
    • (2010) Circulation , vol.121 , pp. 1124-1133
    • Jeon, H.J.1    Choi, J.H.2    Jung, I.H.3
  • 165
    • 84912123135 scopus 로고    scopus 로고
    • CD137-inducing factors from T cells and macrophages accelerate the destabilization of atherosclerotic plaques in hyperlipidemic mice
    • Jung IH, Choi JH, Jin J, CD137-inducing factors from T cells and macrophages accelerate the destabilization of atherosclerotic plaques in hyperlipidemic mice. FASEB J 2014 28 4779 4791. doi: 10.1096/fj.14-253732.
    • (2014) FASEB J , vol.28 , pp. 4779-4791
    • Jung, I.H.1    Choi, J.H.2    Jin, J.3
  • 169
    • 65349084376 scopus 로고    scopus 로고
    • The CD160, BTLA, LIGHT/HVEM pathway: A bidirectional switch regulating T-cell activation
    • Cai G, Freeman GJ, The CD160, BTLA, LIGHT/HVEM pathway: a bidirectional switch regulating T-cell activation. Immunol Rev 2009 229 244 258. doi: 10.1111/j.1600-065X.2009.00783.x.
    • (2009) Immunol Rev , vol.229 , pp. 244-258
    • Cai, G.1    Freeman, G.J.2
  • 171
    • 0035572244 scopus 로고    scopus 로고
    • Tumor necrosis factor receptor superfamily 14 is involved in atherogenesis by inducing proinflammatory cytokines and matrix metalloproteinases
    • Lee WH, Kim SH, Lee Y, Lee BB, Kwon B, Song H, Kwon BS, Park JE, Tumor necrosis factor receptor superfamily 14 is involved in atherogenesis by inducing proinflammatory cytokines and matrix metalloproteinases. Arterioscler Thromb Vasc Biol 2001 21 2004 2010
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 2004-2010
    • Lee, W.H.1    Kim, S.H.2    Lee, Y.3    Lee, B.B.4    Kwon, B.5    Song, H.6    Kwon, B.S.7    Park, J.E.8
  • 180
    • 84947920699 scopus 로고    scopus 로고
    • Human umbilical vein endothelial cells promote the inhibitory activation of CD4(+)CD25(+)Foxp3(+) regulatory T cells via PD-L1
    • Chen WJ, Hu XF, Yan M, Zhang WY, Mao XB, Shu YW, Human umbilical vein endothelial cells promote the inhibitory activation of CD4(+)CD25(+)Foxp3(+) regulatory T cells via PD-L1. Atherosclerosis 2016 244 108 112. doi: 10.1016/j.atherosclerosis.2015.11.002.
    • (2016) Atherosclerosis , vol.244 , pp. 108-112
    • Chen, W.J.1    Hu, X.F.2    Yan, M.3    Zhang, W.Y.4    Mao, X.B.5    Shu, Y.W.6
  • 181
    • 34948904394 scopus 로고    scopus 로고
    • Proatherogenic immune responses are regulated by the PD-1/PD-L pathway in mice
    • Gotsman I, Grabie N, Dacosta R, Sukhova G, Sharpe A, Lichtman AH, Proatherogenic immune responses are regulated by the PD-1/PD-L pathway in mice. J Clin Invest 2007 117 2974 2982. doi: 10.1172/JCI31344.
    • (2007) J Clin Invest , vol.117 , pp. 2974-2982
    • Gotsman, I.1    Grabie, N.2    Dacosta, R.3    Sukhova, G.4    Sharpe, A.5    Lichtman, A.H.6
  • 182
    • 58149461844 scopus 로고    scopus 로고
    • Contributions of PD-1/PD-L1 pathway to interactions of myeloid DCs with T cells in atherosclerosis
    • Lee J, Zhuang Y, Wei X, Shang F, Wang J, Zhang Y, Liu X, Yang Y, Liu L, Zheng Q, Contributions of PD-1/PD-L1 pathway to interactions of myeloid DCs with T cells in atherosclerosis. J Mol Cell Cardiol 2009 46 169 176. doi: 10.1016/j.yjmcc.2008.10.028.
    • (2009) J Mol Cell Cardiol , vol.46 , pp. 169-176
    • Lee, J.1    Zhuang, Y.2    Wei, X.3    Shang, F.4    Wang, J.5    Zhang, Y.6    Liu, X.7    Yang, Y.8    Liu, L.9    Zheng, Q.10
  • 184
    • 84898630794 scopus 로고    scopus 로고
    • Programmed cell death-1 deficiency exacerbates T cell activation and atherogenesis despite expansion of regulatory T cells in atherosclerosis-prone mice
    • Cochain C, Chaudhari SM, Koch M, Wiendl H, Eckstein HH, Zernecke A, Programmed cell death-1 deficiency exacerbates T cell activation and atherogenesis despite expansion of regulatory T cells in atherosclerosis-prone mice. PLoS One 2014 9 e93280. doi: 10.1371/journal.pone.0093280.
    • (2014) PLoS One , vol.9 , pp. e93280
    • Cochain, C.1    Chaudhari, S.M.2    Koch, M.3    Wiendl, H.4    Eckstein, H.H.5    Zernecke, A.6
  • 185
    • 84934967762 scopus 로고    scopus 로고
    • PD-1 and Tim-3 pathways regulate CD8+ T cells function in atherosclerosis
    • Qiu MK, Wang SC, Dai YX, Wang SQ, Ou JM, Quan ZW, PD-1 and Tim-3 pathways regulate CD8+ T cells function in atherosclerosis. PLoS One 2015 10 e0128523. doi: 10.1371/journal.pone.0128523.
    • (2015) PLoS One , vol.10 , pp. e0128523
    • Qiu, M.K.1    Wang, S.C.2    Dai, Y.X.3    Wang, S.Q.4    Ou, J.M.5    Quan, Z.W.6
  • 186
    • 84969528858 scopus 로고    scopus 로고
    • Targeted therapy and checkpoint immunotherapy combinations for the treatment of cancer
    • Hughes PE, Caenepeel S, Wu LC, Targeted therapy and checkpoint immunotherapy combinations for the treatment of cancer. Trends Immunol 2016 37 462 476. doi: 10.1016/j.it.2016.04.010.
    • (2016) Trends Immunol , vol.37 , pp. 462-476
    • Hughes, P.E.1    Caenepeel, S.2    Wu, L.C.3
  • 187
    • 43949105866 scopus 로고    scopus 로고
    • Regulatory T cells and immune tolerance
    • Sakaguchi S, Yamaguchi T, Nomura T, Ono M, Regulatory T cells and immune tolerance. Cell 2008 133 775 787. doi: 10.1016/j.cell.2008.05.009.
    • (2008) Cell , vol.133 , pp. 775-787
    • Sakaguchi, S.1    Yamaguchi, T.2    Nomura, T.3    Ono, M.4
  • 188
    • 0028867420 scopus 로고
    • Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
    • Tivol EA, Borriello F, Schweitzer AN, Lynch WP, Bluestone JA, Sharpe AH, Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 1995 3 541 547
    • (1995) Immunity , vol.3 , pp. 541-547
    • Tivol, E.A.1    Borriello, F.2    Schweitzer, A.N.3    Lynch, W.P.4    Bluestone, J.A.5    Sharpe, A.H.6
  • 190
    • 84872590494 scopus 로고    scopus 로고
    • CTLA4-IgG ameliorates homocysteine-accelerated atherosclerosis by inhibiting T-cell overactivation in apoE(-/-) mice
    • Ma K, Lv S, Liu B, Liu Z, Luo Y, Kong W, Xu Q, Feng J, Wang X, CTLA4-IgG ameliorates homocysteine-accelerated atherosclerosis by inhibiting T-cell overactivation in apoE(-/-) mice. Cardiovasc Res 2013 97 349 359. doi: 10.1093/cvr/cvs330.
    • (2013) Cardiovasc Res , vol.97 , pp. 349-359
    • Ma, K.1    Lv, S.2    Liu, B.3    Liu, Z.4    Luo, Y.5    Kong, W.6    Xu, Q.7    Feng, J.8    Wang, X.9
  • 192
    • 0037333857 scopus 로고    scopus 로고
    • A short course of BG9588 (anti-CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis
    • Boumpas DT, Furie R, Manzi S, Illei GG, Wallace DJ, Balow JE, Vaishnaw A, BG9588 Lupus Nephritis Trial Group A short course of BG9588 (anti-CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis. Arthritis Rheum 2003 48 719 727. doi: 10.1002/art.10856.
    • (2003) Arthritis Rheum , vol.48 , pp. 719-727
    • Boumpas, D.T.1    Furie, R.2    Manzi, S.3    Illei, G.G.4    Wallace, D.J.5    Balow, J.E.6    Vaishnaw, A.7
  • 194
    • 84946068678 scopus 로고    scopus 로고
    • Dacetuzumab plus rituximab, ifosfamide, carboplatin and etoposide as salvage therapy for patients with diffuse large B-cell lymphoma relapsing after rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone: A randomized, double-blind, placebo-controlled phase 2b trial
    • Fayad L, Ansell SM, Advani R, Coiffier B, Stuart R, Bartlett NL, Forero-Torres A, Kuliczkowski K, Belada D, Ng E, Drachman JG, Dacetuzumab plus rituximab, ifosfamide, carboplatin and etoposide as salvage therapy for patients with diffuse large B-cell lymphoma relapsing after rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone: a randomized, double-blind, placebo-controlled phase 2b trial. Leuk Lymphoma 2015 56 2569 2578. doi: 10.3109/10428194.2015.1007504.
    • (2015) Leuk Lymphoma , vol.56 , pp. 2569-2578
    • Fayad, L.1    Ansell, S.M.2    Advani, R.3    Coiffier, B.4    Stuart, R.5    Bartlett, N.L.6    Forero-Torres, A.7    Kuliczkowski, K.8    Belada, D.9    Ng, E.10    Drachman, J.G.11
  • 196
    • 84891626501 scopus 로고    scopus 로고
    • Phase IA/II, multicentre, open-label study of the CD40 antagonistic monoclonal antibody lucatumumab in adult patients with advanced non-Hodgkin or Hodgkin lymphoma
    • Fanale M, Assouline S, Kuruvilla J, Phase IA/II, multicentre, open-label study of the CD40 antagonistic monoclonal antibody lucatumumab in adult patients with advanced non-Hodgkin or Hodgkin lymphoma. Br J Haematol 2014 164 258 265. doi: 10.1111/bjh.12630.
    • (2014) Br J Haematol , vol.164 , pp. 258-265
    • Fanale, M.1    Assouline, S.2    Kuruvilla, J.3
  • 197
    • 84950150279 scopus 로고    scopus 로고
    • The many faces of Mac-1 in autoimmune disease
    • Rosetti F, Mayadas TN, The many faces of Mac-1 in autoimmune disease. Immunol Rev 2016 269 175 193. doi: 10.1111/imr.12373.
    • (2016) Immunol Rev , vol.269 , pp. 175-193
    • Rosetti, F.1    Mayadas, T.N.2
  • 198
    • 81355148688 scopus 로고    scopus 로고
    • Binding of CD40L to Mac-1's I-domain involves the EQLKKSKTL motif and mediates leukocyte recruitment and atherosclerosis-but does not affect immunity and thrombosis in mice
    • Wolf D, Hohmann JD, Wiedemann A, Binding of CD40L to Mac-1's I-domain involves the EQLKKSKTL motif and mediates leukocyte recruitment and atherosclerosis-but does not affect immunity and thrombosis in mice. Circ Res 2011 109 1269 1279. doi: 10.1161/CIRCRESAHA.111.247684.
    • (2011) Circ Res , vol.109 , pp. 1269-1279
    • Wolf, D.1    Hohmann, J.D.2    Wiedemann, A.3
  • 200
    • 84894377101 scopus 로고    scopus 로고
    • Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance
    • Chatzigeorgiou A, Seijkens T, Zarzycka B, Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance. Proc Natl Acad Sci U S A 2014 111 2686 2691. doi: 10.1073/pnas.1400419111.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 2686-2691
    • Chatzigeorgiou, A.1    Seijkens, T.2    Zarzycka, B.3
  • 201
    • 23644449236 scopus 로고    scopus 로고
    • Identification of CD70 as a diagnostic biomarker for clear cell renal cell carcinoma by gene expression profiling, real-time RT-PCR and immunohistochemistry
    • Diegmann J, Junker K, Gerstmayer B, Bosio A, Hindermann W, Rosenhahn J, von Eggeling F, Identification of CD70 as a diagnostic biomarker for clear cell renal cell carcinoma by gene expression profiling, real-time RT-PCR and immunohistochemistry. Eur J Cancer 2005 41 1794 1801. doi: 10.1016/j.ejca.2005.05.005.
    • (2005) Eur J Cancer , vol.41 , pp. 1794-1801
    • Diegmann, J.1    Junker, K.2    Gerstmayer, B.3    Bosio, A.4    Hindermann, W.5    Rosenhahn, J.6    Von Eggeling, F.7
  • 207
    • 41049095846 scopus 로고    scopus 로고
    • CD70 as a therapeutic target in human malignancies
    • Grewal IS, CD70 as a therapeutic target in human malignancies. Expert Opin Ther Targets 2008 12 341 351. doi: 10.1517/14728222.12.3.341.
    • (2008) Expert Opin Ther Targets , vol.12 , pp. 341-351
    • Grewal, I.S.1
  • 208
    • 84874863777 scopus 로고    scopus 로고
    • Accessed October 22, 2016
    • Registry of Clinical Trials ClinicalTrials Web site. https://clinicaltrials.gov/. Accessed October 22, 2016.
    • ClinicalTrials Web Site.
  • 209
    • 84937677526 scopus 로고    scopus 로고
    • Targeting the T-cell co-stimulatory CD27/CD70 pathway in cancer immunotherapy: Rationale and potential
    • van de Ven K, Borst J, Targeting the T-cell co-stimulatory CD27/CD70 pathway in cancer immunotherapy: rationale and potential. Immunotherapy 2015 7 655 667
    • (2015) Immunotherapy , vol.7 , pp. 655-667
    • Van De Ven, K.1    Borst, J.2
  • 210
    • 84874863777 scopus 로고    scopus 로고
    • Accessed October 22, 2016
    • Registry of Clinical Trials ClinicalTrials Web site. https://clinicaltrials.gov/. Accessed October 22, 2016.
    • ClinicalTrials Web Site.
  • 212
    • 84965032301 scopus 로고    scopus 로고
    • Safety profiles of anti-CTLA-4 and anti-PD-1 antibodies alone and in combination
    • Boutros C, Tarhini A, Routier E, Safety profiles of anti-CTLA-4 and anti-PD-1 antibodies alone and in combination. Nat Rev Clin Oncol 2016 13 473 486. doi: 10.1038/nrclinonc.2016.58.
    • (2016) Nat Rev Clin Oncol , vol.13 , pp. 473-486
    • Boutros, C.1    Tarhini, A.2    Routier, E.3
  • 213
    • 84936147067 scopus 로고    scopus 로고
    • Combined nivolumab and ipilimumab or monotherapy in untreated melanoma
    • Larkin J, Chiarion-Sileni V, Gonzalez R, Combined nivolumab and ipilimumab or monotherapy in untreated melanoma. N Engl J Med 2015 373 23 34. doi: 10.1056/NEJMoa1504030.
    • (2015) N Engl J Med , vol.373 , pp. 23-34
    • Larkin, J.1    Chiarion-Sileni, V.2    Gonzalez, R.3


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