메뉴 건너뛰기




Volumn 108, Issue 2, 2011, Pages 235-248

Oxidation-specific epitopes are danger-associated molecular patterns recognized by pattern recognition receptors of innate immunity

Author keywords

innate immunity; oxidation specific epitopes; oxidized lipids

Indexed keywords

ANTIBODY; C REACTIVE PROTEIN; CD14 ANTIGEN; CD36 ANTIGEN; CHOLESTEROL ESTER; EPITOPE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN M; LIPID HYDROPEROXIDE; LOW DENSITY LIPOPROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1; PATTERN RECOGNITION RECEPTOR; PHOSPHOLIPID; PROTEIN MD 2; SCAVENGER RECEPTOR; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 6;

EID: 79251580687     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.110.223875     Document Type: Article
Times cited : (510)

References (127)
  • 1
    • 0024955886 scopus 로고
    • Approaching the asymptote? Evolution and revolution in immunology
    • Janeway CA Jr. Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb Symp Quant Biol. 1989;54 Pt 1:1-13.
    • (1989) Cold Spring Harb Symp Quant Biol , vol.54 , Issue.PART 1 , pp. 1-13
    • Janeway Jr., C.A.1
  • 2
    • 0037066502 scopus 로고    scopus 로고
    • Decoding the patterns of self and nonself by the innate immune system
    • Medzhitov R, Janeway CA Jr. Decoding the patterns of self and nonself by the innate immune system. Science. 2002;296:298-300.
    • (2002) Science , vol.296 , pp. 298-300
    • Medzhitov, R.1    Janeway Jr., C.A.2
  • 3
    • 66949122854 scopus 로고    scopus 로고
    • Approaching the asymptote: 20 years later
    • Medzhitov R. Approaching the asymptote: 20 years later. Immunity. 2009;30:766-775.
    • (2009) Immunity , vol.30 , pp. 766-775
    • Medzhitov, R.1
  • 4
    • 0037066427 scopus 로고    scopus 로고
    • The danger model: A renewed sense of self
    • Matzinger P. The danger model: a renewed sense of self. Science. 2002;296:301-305.
    • (2002) Science , vol.296 , pp. 301-305
    • Matzinger, P.1
  • 5
    • 0033033704 scopus 로고    scopus 로고
    • Receptors for oxidized low-density lipoprotein on elicited mouse peritoneal macrophages can recognize both the modified lipid moieties and the modified protein moieties: Implications with respect to macrophage recognition of apoptotic cells
    • Bird DA, Gillotte KL, Hörkkö S, Friedman P, Dennis EA, Witztum JL, Steinberg D. Receptors for oxidized low-density lipoprotein on elicited mouse peritoneal macrophages can recognize both the modified lipid moieties and the modified protein moieties: implications with respect to macrophage recognition of apoptotic cells. Proc Natl Acad Sci USA. 1999;96:6347-6352.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 6347-6352
    • Bird, D.A.1    Gillotte, K.L.2    Hörkkö, S.3    Friedman, P.4    Dennis, E.A.5    Witztum, J.L.6    Steinberg, D.7
  • 6
    • 0032989435 scopus 로고    scopus 로고
    • Monoclonal antibodies against oxidized low-density lipoprotein bind to apoptotic cells and inhibit their phagocytosis by elicited macrophages: Evidence that oxidation-specific epitopes mediate macrophage recognition
    • Chang MK, Bergmark C, Laurila A, Hörkkö S, Han KH, Friedman P, Dennis EA, Witztum JL. Monoclonal antibodies against oxidized low-density lipoprotein bind to apoptotic cells and inhibit their phagocytosis by elicited macrophages: evidence that oxidation-specific epitopes mediate macrophage recognition. Proc Natl Acad Sci USA. 1999;96: 6353-6358.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 6353-6358
    • Chang, M.K.1    Bergmark, C.2    Laurila, A.3    Hörkkö, S.4    Han, K.H.5    Friedman, P.6    Dennis, E.A.7    Witztum, J.L.8
  • 8
    • 0030730023 scopus 로고    scopus 로고
    • The other side of scavenger receptors: Pattern recognition for host defense
    • Krieger M. The other side of scavenger receptors: pattern recognition for host defense. Curr Opin Lipidol. 1997;8:275-280.
    • (1997) Curr Opin Lipidol , vol.8 , pp. 275-280
    • Krieger, M.1
  • 10
    • 0042031044 scopus 로고    scopus 로고
    • Receptors involved in the Ox-PAPC-mediated synthesis of IL-8: A role for toll-like receptor 4 and a GPI anchored protein
    • Walton KA, Hsieh X, Gharavi N, Wang S, Wang G, Yeh M, Cole AL, Berliner JA. Receptors involved in the Ox-PAPC-mediated synthesis of IL-8: a role for toll-like receptor 4 and a GPI anchored protein. J Biol Chem. 2003;278:29661-29666.
    • (2003) J Biol Chem , vol.278 , pp. 29661-29666
    • Walton, K.A.1    Hsieh, X.2    Gharavi, N.3    Wang, S.4    Wang, G.5    Yeh, M.6    Cole, A.L.7    Berliner, J.A.8
  • 12
    • 27644443295 scopus 로고    scopus 로고
    • Dorsoventral axis formation in the drosophila embryo-shaping and transducing a morphogen gradient
    • Moussian B, Roth S. Dorsoventral axis formation in the drosophila embryo-shaping and transducing a morphogen gradient. Curr Biol. 2005;15:R887-R899.
    • (2005) Curr Biol , vol.15
    • Moussian, B.1    Roth, S.2
  • 13
    • 61449231622 scopus 로고    scopus 로고
    • Evolution of lipopolysaccharide (LPS) recognition and signaling: Fish TLR4 does not recognize LPS and negatively regulates NF-{kappa}B activation
    • Sepulcre MP, Alcaraz-Pérez F, López-Muñoz A, Roca FJ, Meseguer J, Cayuela ML, Mulero V. Evolution of lipopolysaccharide (LPS) recognition and signaling: fish TLR4 does not recognize LPS and negatively regulates NF-{kappa}B activation. J Immunol. 2009;182:1836-1845.
    • (2009) J Immunol , vol.182 , pp. 1836-1845
    • Sepulcre, M.P.1    Alcaraz-Pérez, F.2    López-Muñoz, A.3    Roca, F.J.4    Meseguer, J.5    Cayuela, M.L.6    Mulero, V.7
  • 15
    • 0034659164 scopus 로고    scopus 로고
    • Myeloperoxidase-generated oxidants and atherosclerosis
    • Podrez EA, Abu-Soud HM, Hazen SL. Myeloperoxidase-generated oxidants and atherosclerosis. Free Radic Biol Med. 2000;28:1717-1725.
    • (2000) Free Radic Biol Med , vol.28 , pp. 1717-1725
    • Podrez, E.A.1    Abu-Soud, H.M.2    Hazen, S.L.3
  • 16
    • 0034659148 scopus 로고    scopus 로고
    • The oxidative modification hypothesis of atherogenesis: An overview
    • Chisolm GM, Steinberg D. The oxidative modification hypothesis of atherogenesis: an overview. Free Radic Biol Med. 2000;28:1815-1826.
    • (2000) Free Radic Biol Med , vol.28 , pp. 1815-1826
    • Chisolm, G.M.1    Steinberg, D.2
  • 17
    • 67449123456 scopus 로고    scopus 로고
    • HDL, lipid peroxidation, and atherosclerosis
    • Shao B, Heinecke JW. HDL, lipid peroxidation, and atherosclerosis. J Lipid Res. 2009;50:599-601.
    • (2009) J Lipid Res , vol.50 , pp. 599-601
    • Shao, B.1    Heinecke, J.W.2
  • 18
    • 77952310420 scopus 로고    scopus 로고
    • Lipoprotein modification and macrophage uptake: Role of pathologic cholesterol transport in athero-genesis
    • Miller YI, Choi S-H, Fang L, Tsimikas S. Lipoprotein modification and macrophage uptake: role of pathologic cholesterol transport in athero-genesis. Subcell Biochem. 2010;51:229-251.
    • (2010) Subcell Biochem , vol.51 , pp. 229-251
    • Miller, Y.I.1    Choi, S.-H.2    Fang, L.3    Tsimikas, S.4
  • 19
    • 0000061171 scopus 로고
    • Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospho-lipids
    • Steinbrecher UP, Parthasarathy S, Leake DS, Witztum JL, Steinberg D. Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospho-lipids. Proc Natl Acad Sci USA. 1984;81:3883-3887.
    • (1984) Proc Natl Acad Sci USA , vol.81 , pp. 3883-3887
    • Steinbrecher, U.P.1    Parthasarathy, S.2    Leake, D.S.3    Witztum, J.L.4    Steinberg, D.5
  • 20
    • 0023198480 scopus 로고
    • Autoxidation of human low density lipoprotein: Loss of polyunsaturated fatty acids and vitamin e and generation of aldehydes
    • Esterbauer H, Jurgens G, Quehenberger O, Koller E. Autoxidation of human low density lipoprotein: loss of polyunsaturated fatty acids and vitamin E and generation of aldehydes. J Lipid Res. 1987;28:495-509.
    • (1987) J Lipid Res , vol.28 , pp. 495-509
    • Esterbauer, H.1    Jurgens, G.2    Quehenberger, O.3    Koller, E.4
  • 21
    • 0027402693 scopus 로고
    • Effects of oleate-rich and linoleate-rich diets on the susceptibility of low density lipoprotein to oxidative modification in mildly hypercho- lesterolemic subjects
    • Reaven P, Parthasarathy S, Grasse BJ, Miller E, Steinberg D, Witztum JL. Effects of oleate-rich and linoleate-rich diets on the susceptibility of low density lipoprotein to oxidative modification in mildly hypercho-lesterolemic subjects. J Clin Invest. 1993;91:668-676.
    • (1993) J Clin Invest , vol.91 , pp. 668-676
    • Reaven, P.1    Parthasarathy, S.2    Grasse, B.J.3    Miller, E.4    Steinberg, D.5    Witztum, J.L.6
  • 22
    • 0026657363 scopus 로고
    • The role of lipid peroxi-dation and antioxidants in oxidative modification of LDL
    • Esterbauer H, Gebicki J, Puhl H, Jurgens G. The role of lipid peroxi-dation and antioxidants in oxidative modification of LDL. Free Radic Biol Med. 1992;13:341-390.
    • (1992) Free Radic Biol Med , vol.13 , pp. 341-390
    • Esterbauer, H.1    Gebicki, J.2    Puhl, H.3    Jurgens, G.4
  • 24
    • 0026480564 scopus 로고
    • Mammalian lipoxygenases: Molecular structures and functions
    • Yamamoto S. Mammalian lipoxygenases: molecular structures and functions. Biochim Biophys Acta. 1992;1128:117-131.
    • (1992) Biochim Biophys Acta , vol.1128 , pp. 117-131
    • Yamamoto, S.1
  • 25
    • 0029151215 scopus 로고
    • Lipoperoxides in LDL incubated with fibroblasts that overexpress 15-lipoxygenase
    • Ezaki M, Witztum JL, Steinberg D. Lipoperoxides in LDL incubated with fibroblasts that overexpress 15-lipoxygenase. J Lipid Res. 1995; 36:1996-2004.
    • (1995) J Lipid Res , vol.36 , pp. 1996-2004
    • Ezaki, M.1    Witztum, J.L.2    Steinberg, D.3
  • 26
    • 44849094277 scopus 로고    scopus 로고
    • Cholesteryl ester hydroperoxides are biologically active components of minimally oxidized LDL
    • Harkewicz R, Hartvigsen K, Almazan F, Dennis EA, Witztum JL, Miller YI. Cholesteryl ester hydroperoxides are biologically active components of minimally oxidized LDL. J Biol Chem. 2008;283:10241-10251.
    • (2008) J Biol Chem , vol.283 , pp. 10241-10251
    • Harkewicz, R.1    Hartvigsen, K.2    Almazan, F.3    Dennis, E.A.4    Witztum, J.L.5    Miller, Y.I.6
  • 28
    • 3242712279 scopus 로고    scopus 로고
    • Lipoxygenase pathways in atherogenesis
    • Zhao L, Funk CD. Lipoxygenase pathways in atherogenesis. Trends Cardiovasc Med. 2004;14:191-195.
    • (2004) Trends Cardiovasc Med , vol.14 , pp. 191-195
    • Zhao, L.1    Funk, C.D.2
  • 30
    • 0042170261 scopus 로고    scopus 로고
    • Cholesteryl ester oxidation products in atherosclerosis
    • Leitinger N. Cholesteryl ester oxidation products in atherosclerosis. Mol Aspects Med. 2003;24:239-250.
    • (2003) Mol Aspects Med , vol.24 , pp. 239-250
    • Leitinger, N.1
  • 31
    • 0009627006 scopus 로고
    • Binding site on macro-phages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition
    • Goldstein JL, Ho YK, Basu SK, Brown MS. Binding site on macro-phages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition. Proc Natl Acad Sci USA. 1979;76:333-337.
    • (1979) Proc Natl Acad Sci USA , vol.76 , pp. 333-337
    • Goldstein, J.L.1    Ho, Y.K.2    Basu, S.K.3    Brown, M.S.4
  • 32
    • 38349132245 scopus 로고    scopus 로고
    • Macrophage-derived foam cells in atherosclerosis: Lessons from murine models and implications for therapy
    • Webb NR, Moore KJ. Macrophage-derived foam cells in atherosclerosis: lessons from murine models and implications for therapy. Curr Drug Targets. 2007;8:1249-1263.
    • (2007) Curr Drug Targets , vol.8 , pp. 1249-1263
    • Webb, N.R.1    Moore, K.J.2
  • 33
    • 34848905092 scopus 로고    scopus 로고
    • Macrophage scavenger receptors and host-derived ligands
    • Pluddemann A, Neyen C, Gordon S. Macrophage scavenger receptors and host-derived ligands. Methods. 2007;43:207-217.
    • (2007) Methods , vol.43 , pp. 207-217
    • Pluddemann, A.1    Neyen, C.2    Gordon, S.3
  • 34
    • 0346037268 scopus 로고    scopus 로고
    • Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages
    • Kunjathoor VV, Febbraio M, Podrez EA, Moore KJ, Andersson L, Koehn S, Rhee JS, Silverstein R, Hoff HF, Freeman MW. Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages. J Biol Chem. 2002;277:49982-49988.
    • (2002) J Biol Chem , vol.277 , pp. 49982-49988
    • Kunjathoor, V.V.1    Febbraio, M.2    Podrez, E.A.3    Moore, K.J.4    Andersson, L.5    Koehn, S.6    Rhee, J.S.7    Silverstein, R.8    Hoff, H.F.9    Freeman, M.W.10
  • 36
    • 0034737582 scopus 로고    scopus 로고
    • The binding of oxidized low density lipoprotein to mouse CD36 is mediated in part by oxidized phospholipids that are associated with both the lipid and protein moieties of the lipoprotein
    • Boullier A, Gillotte KL, Hörkkö S, Green SR, Friedman P, Dennis EA, Witztum JL, Steinberg D, Quehenberger O. The binding of oxidized low density lipoprotein to mouse CD36 is mediated in part by oxidized phospholipids that are associated with both the lipid and protein moieties of the lipoprotein. J Biol Chem. 2000;275:9163-9169.
    • (2000) J Biol Chem , vol.275 , pp. 9163-9169
    • Boullier, A.1    Gillotte, K.L.2    Hörkkö, S.3    Green, S.R.4    Friedman, P.5    Dennis, E.A.6    Witztum, J.L.7    Steinberg, D.8    Quehenberger, O.9
  • 39
    • 0343238361 scopus 로고    scopus 로고
    • Oxidized phospho-lipids, linked to apolipoprotein B of oxidized LDL, are ligands for macrophage scavenger receptors
    • Gillotte KL, Hörkkö S, Witztum JL, Steinberg D. Oxidized phospho-lipids, linked to apolipoprotein B of oxidized LDL, are ligands for macrophage scavenger receptors. J Lipid Res. 2000;41:824-833.
    • (2000) J Lipid Res , vol.41 , pp. 824-833
    • Gillotte, K.L.1    Hörkkö, S.2    Witztum, J.L.3    Steinberg, D.4
  • 40
    • 0036510381 scopus 로고    scopus 로고
    • Correlation of antiphospholipid antibody recognition with the structure of synthetic oxidized phospholipids: Importance of Schiff base formation and aldol condensation
    • Friedman P, Hörkkö S, Steinberg D, Witztum JL, Dennis EA. Correlation of antiphospholipid antibody recognition with the structure of synthetic oxidized phospholipids: importance of Schiff base formation and aldol condensation. J Biol Chem. 2002;277:7010-7020.
    • (2002) J Biol Chem , vol.277 , pp. 7010-7020
    • Friedman, P.1    Hörkkö, S.2    Steinberg, D.3    Witztum, J.L.4    Dennis, E.A.5
  • 43
    • 33751519372 scopus 로고    scopus 로고
    • Oxidized phosphatidylserine-CD36 interactions play an essential role in macrophage-dependent phagocytosis of apoptotic cells
    • Greenberg ME, Sun M, Zhang R, Febbraio M, Silverstein R, Hazen SL. Oxidized phosphatidylserine-CD36 interactions play an essential role in macrophage-dependent phagocytosis of apoptotic cells. J Exp Med. 2006;203:2613-2625.
    • (2006) J Exp Med , vol.203 , pp. 2613-2625
    • Greenberg, M.E.1    Sun, M.2    Zhang, R.3    Febbraio, M.4    Silverstein, R.5    Hazen, S.L.6
  • 45
    • 47049100720 scopus 로고    scopus 로고
    • Oxidized phospholipids as endogenous pattern recognition ligands in innate immunity
    • Hazen SL. Oxidized phospholipids as endogenous pattern recognition ligands in innate immunity. J Biol Chem. 2008;283:15527-15531.
    • (2008) J Biol Chem , vol.283 , pp. 15527-15531
    • Hazen, S.L.1
  • 46
    • 0025754164 scopus 로고
    • Expression of type i and type II bovine scavenger receptors in Chinese hamster ovary cells: Lipid droplet accumulation and nonreciprocal cross competition by acetylated and oxidized low density lipoprotein
    • Freeman M, Ekkel Y, Rohrer L, Penman M, Freedman NJ, Chisolm GM, Krieger M. Expression of type I and type II bovine scavenger receptors in Chinese hamster ovary cells: lipid droplet accumulation and nonreciprocal cross competition by acetylated and oxidized low density lipoprotein. Proc Natl Acad Sci USA 1991; 88: 4931-4935.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 4931-4935
    • Freeman, M.1    Ekkel, Y.2    Rohrer, L.3    Penman, M.4    Freedman, N.J.5    Chisolm, G.M.6    Krieger, M.7
  • 47
    • 33749065328 scopus 로고    scopus 로고
    • Roles for accessory molecules in microbial recognition by Toll-like receptors
    • Miyake K. Roles for accessory molecules in microbial recognition by Toll-like receptors. J Endotoxin Res. 2006;12:195-204.
    • (2006) J Endotoxin Res , vol.12 , pp. 195-204
    • Miyake, K.1
  • 48
    • 67349182481 scopus 로고    scopus 로고
    • The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex
    • Park BS, Song DH, Kim HM, Choi BS, Lee H, Lee JO. The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex. Nature. 2009;458:1191-1195.
    • (2009) Nature , vol.458 , pp. 1191-1195
    • Park, B.S.1    Song, D.H.2    Kim, H.M.3    Choi, B.S.4    Lee, H.5    Lee, J.O.6
  • 52
    • 66349115622 scopus 로고    scopus 로고
    • Emerging role of Toll-like receptors in atherosclerosis
    • Curtiss LK, Tobias PS. Emerging role of Toll-like receptors in atherosclerosis. J Lipid Res. 2009;50:S340-S345.
    • (2009) J Lipid Res , vol.50
    • Curtiss, L.K.1    Tobias, P.S.2
  • 53
    • 0037449723 scopus 로고    scopus 로고
    • Minimally modified LDL binds to CD14, induces macro-phage spreading via TLR4/MD-2, and inhibits phagocytosis of apoptotic cells
    • Miller YI, Viriyakosol S, Binder CJ, Feramisco JR, Kirkland TN, Witztum JL. Minimally modified LDL binds to CD14, induces macro-phage spreading via TLR4/MD-2, and inhibits phagocytosis of apoptotic cells. J Biol Chem. 2003;278:1561-1568.
    • (2003) J Biol Chem , vol.278 , pp. 1561-1568
    • Miller, Y.I.1    Viriyakosol, S.2    Binder, C.J.3    Feramisco, J.R.4    Kirkland, T.N.5    Witztum, J.L.6
  • 55
    • 0037026527 scopus 로고    scopus 로고
    • Protective role of phospholipid oxidation products in endotoxin-induced tissue damage
    • Bochkov VN, Kadl A, Huber J, Gruber F, Binder BR, Leitinger N. Protective role of phospholipid oxidation products in endotoxin-induced tissue damage. Nature. 2002;419:77-81.
    • (2002) Nature , vol.419 , pp. 77-81
    • Bochkov, V.N.1    Kadl, A.2    Huber, J.3    Gruber, F.4    Binder, B.R.5    Leitinger, N.6
  • 58
    • 0036791022 scopus 로고    scopus 로고
    • C-reactive protein binds to both oxidized LDL and apoptotic cells through recognition of a common ligand: Phosphorylcholine of oxidized phospholipids
    • Chang MK, Binder CJ, Torzewski M, Witztum JL. C-reactive protein binds to both oxidized LDL and apoptotic cells through recognition of a common ligand: phosphorylcholine of oxidized phospholipids. Proc Natl Acad Sci USA. 2002;99:13043-13048.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 13043-13048
    • Chang, M.K.1    Binder, C.J.2    Torzewski, M.3    Witztum, J.L.4
  • 61
    • 16344380083 scopus 로고    scopus 로고
    • Inherent specificities in natural antibodies: A key to immune defense against pathogen invasion
    • Baumgarth N, Tung JW, Herzenberg LA. Inherent specificities in natural antibodies: a key to immune defense against pathogen invasion. Springer Semin Immunopathol. 2005;26:347-362.
    • (2005) Springer Semin Immunopathol , vol.26 , pp. 347-362
    • Baumgarth, N.1    Tung, J.W.2    Herzenberg, L.A.3
  • 62
    • 0029957467 scopus 로고    scopus 로고
    • Cloning of monoclonal autoantibodies to epitopes of oxidized lipoproteins from apolipoprotein E-deficient mice. Demonstration of epitopes of oxidized low density lipoprotein in human plasma
    • Palinski W, Horkko S, Miller E, Steinbrecher UP, Powell HC, Curtiss LK, Witztum JL. Cloning of monoclonal autoantibodies to epitopes of oxidized lipoproteins from apolipoprotein E-deficient mice. Demonstration of epitopes of oxidized low density lipoprotein in human plasma. J Clin Invest. 1996;98:800-814.
    • (1996) J Clin Invest , vol.98 , pp. 800-814
    • Palinski, W.1    Horkko, S.2    Miller, E.3    Steinbrecher, U.P.4    Powell, H.C.5    Curtiss, L.K.6    Witztum, J.L.7
  • 64
    • 0342939538 scopus 로고    scopus 로고
    • Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity
    • Shaw PX, Hörkkö S, Chang MK, Curtiss LK, Palinski W, Silverman GJ, Witztum JL. Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity. J Clin Invest. 2000;105:1731-1740.
    • (2000) J Clin Invest , vol.105 , pp. 1731-1740
    • Shaw, P.X.1    Hörkkö, S.2    Chang, M.K.3    Curtiss, L.K.4    Palinski, W.5    Silverman, G.J.6    Witztum, J.L.7
  • 66
    • 33747379849 scopus 로고    scopus 로고
    • A natural antibody to oxidized cardiolipin binds to oxidized low-density lipoprotein, apoptotic cells, and atherosclerotic lesions
    • Tuominen A, Miller YI, Hansen LF, Kesaniemi YA, Witztum JL, Horkko S. A natural antibody to oxidized cardiolipin binds to oxidized low-density lipoprotein, apoptotic cells, and atherosclerotic lesions. Arterioscler Thromb Vasc Biol. 2006;26:2096-2102.
    • (2006) Arterioscler Thromb Vasc Biol , vol.26 , pp. 2096-2102
    • Tuominen, A.1    Miller, Y.I.2    Hansen, L.F.3    Kesaniemi, Y.A.4    Witztum, J.L.5    Horkko, S.6
  • 69
    • 0035376983 scopus 로고    scopus 로고
    • 12/15-Li-poxygenase translocation enhances site-specific actin polymerization in macrophages phagocytosing apoptotic cells
    • Miller YI, Chang MK, Funk CD, Feramisco JR, Witztum JL. 12/15-Li-poxygenase translocation enhances site-specific actin polymerization in macrophages phagocytosing apoptotic cells. J Biol Chem. 2001;276: 19431-19439.
    • (2001) J Biol Chem , vol.276 , pp. 19431-19439
    • Miller, Y.I.1    Chang, M.K.2    Funk, C.D.3    Feramisco, J.R.4    Witztum, J.L.5
  • 70
    • 0141429953 scopus 로고    scopus 로고
    • Actin polymerization in macrophages in response to oxidized LDL and apo-ptotic cells: Role of 12/15-lipoxygenase and phosphoinositide 3-kinase
    • Miller YI, Worrall DS, Funk CD, Feramisco JR, Witztum JL. Actin polymerization in macrophages in response to oxidized LDL and apo-ptotic cells: role of 12/15-lipoxygenase and phosphoinositide 3-kinase. Mol Biol Cell. 2003;14:4196-4206.
    • (2003) Mol Biol Cell , vol.14 , pp. 4196-4206
    • Miller, Y.I.1    Worrall, D.S.2    Funk, C.D.3    Feramisco, J.R.4    Witztum, J.L.5
  • 71
    • 72949116358 scopus 로고    scopus 로고
    • Macrophage death and defective inflammation resolution in atherosclerosis
    • Tabas I. Macrophage death and defective inflammation resolution in atherosclerosis. Nat Rev Immunol. 2010;10:36-46.
    • (2010) Nat Rev Immunol , vol.10 , pp. 36-46
    • Tabas, I.1
  • 72
    • 20144385204 scopus 로고    scopus 로고
    • Toll-like receptor 4-dependent and-independent cytokine secretion induced by minimally oxidized low-density lipoprotein in macrophages
    • Miller YI, Viriyakosol S, Worrall DS, Boullier A, Butler S, Witztum JL. Toll-like receptor 4-dependent and-independent cytokine secretion induced by minimally oxidized low-density lipoprotein in macrophages. Arterioscler Thromb Vasc Biol. 2005;25:1213-1219.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 1213-1219
    • Miller, Y.I.1    Viriyakosol, S.2    Worrall, D.S.3    Boullier, A.4    Butler, S.5    Witztum, J.L.6
  • 73
    • 0023192020 scopus 로고
    • Oxidatively modified low density lipoproteins: A potential role in recruitment and retention of monocyte/macrophages during atherogenesis
    • Quinn MT, Parthasarathy S, Fong LG, Steinberg D. Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte/macrophages during atherogenesis. Proc Natl Acad Sci USA. 1987;84:2995-2998.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 2995-2998
    • Quinn, M.T.1    Parthasarathy, S.2    Fong, L.G.3    Steinberg, D.4
  • 74
    • 61749103652 scopus 로고    scopus 로고
    • CD36 modulates migration of mouse and human macrophages in response to oxidized LDL and may contribute to macrophage trapping in the arterial intima
    • Park YM, Febbraio M, Silverstein RL. CD36 modulates migration of mouse and human macrophages in response to oxidized LDL and may contribute to macrophage trapping in the arterial intima. J Clin Invest. 2009;119:136-145.
    • (2009) J Clin Invest , vol.119 , pp. 136-145
    • Park, Y.M.1    Febbraio, M.2    Silverstein, R.L.3
  • 75
    • 37349021003 scopus 로고    scopus 로고
    • Subendothelial lipoprotein retention as the initiating process in atherosclerosis: Update and therapeutic implications
    • Tabas I, Williams KJ, Boren J. Subendothelial lipoprotein retention as the initiating process in atherosclerosis: update and therapeutic implications. Circulation. 2007;116:1832-1844.
    • (2007) Circulation , vol.116 , pp. 1832-1844
    • Tabas, I.1    Williams, K.J.2    Boren, J.3
  • 76
    • 23644458916 scopus 로고    scopus 로고
    • You are right too!
    • Witztum JL. You are right too! J Clin Invest. 2005;115:2072-2075.
    • (2005) J Clin Invest , vol.115 , pp. 2072-2075
    • Witztum, J.L.1
  • 78
    • 34248640285 scopus 로고    scopus 로고
    • Physiological and pathological roles of a multi-ligand receptor CD36 in atherogenesis; Insights from CD36-deficient patients
    • Yamashita S, Hirano K, Kuwasako T, Janabi M, Toyama Y, Ishigami M, Sakai N. Physiological and pathological roles of a multi-ligand receptor CD36 in atherogenesis; insights from CD36-deficient patients. Mol Cell Biochem. 2007;299:19-22.
    • (2007) Mol Cell Biochem , vol.299 , pp. 19-22
    • Yamashita, S.1    Hirano, K.2    Kuwasako, T.3    Janabi, M.4    Toyama, Y.5    Ishigami, M.6    Sakai, N.7
  • 82
    • 41149126649 scopus 로고    scopus 로고
    • Absence of CD36 protects against atherosclerosis in ApoE knock-out mice with no additional protection provided by absence of scavenger receptor A I/II
    • Kuchibhotla S, Vanegas D, Kennedy DJ, Guy E, Nimako G, Morton RE, Febbraio M. Absence of CD36 protects against atherosclerosis in ApoE knock-out mice with no additional protection provided by absence of scavenger receptor A I/II. Cardiovasc Res. 2008;78:185-196.
    • (2008) Cardiovasc Res , vol.78 , pp. 185-196
    • Kuchibhotla, S.1    Vanegas, D.2    Kennedy, D.J.3    Guy, E.4    Nimako, G.5    Morton, R.E.6    Febbraio, M.7
  • 83
    • 23644435612 scopus 로고    scopus 로고
    • Loss of receptor-mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice
    • Moore KJ, Kunjathoor VV, Koehn SL, Manning JJ, Tseng AA, Silver JM, McKee M, Freeman MW. Loss of receptor-mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice. J Clin Invest. 2005;115:2192-2201.
    • (2005) J Clin Invest , vol.115 , pp. 2192-2201
    • Moore, K.J.1    Kunjathoor, V.V.2    Koehn, S.L.3    Manning, J.J.4    Tseng, A.A.5    Silver, J.M.6    McKee, M.7    Freeman, M.W.8
  • 86
    • 39549120661 scopus 로고    scopus 로고
    • Increased endothelial expression of Toll-like receptor 2 at sites of disturbed blood flow exacerbates early atherogenic events
    • Mullick AE, Soldau K, Kiosses WB, Bell TA III, Tobias PS, Curtiss LK. Increased endothelial expression of Toll-like receptor 2 at sites of disturbed blood flow exacerbates early atherogenic events. J Exp Med. 2008;205:373-383.
    • (2008) J Exp Med , vol.205 , pp. 373-383
    • Mullick, A.E.1    Soldau, K.2    Kiosses, W.B.3    Tobias, P.S.4    Curtiss, L.K.5
  • 87
    • 3242710174 scopus 로고    scopus 로고
    • Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein e
    • Michelsen KS, Wong MH, Shah PK, Zhang W, Yano J, Doherty TM, Akira S, Rajavashisth TB, Arditi M. Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E. Proc Natl Acad Sci USA. 2004;101:10679-10684.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 10679-10684
    • Michelsen, K.S.1    Wong, M.H.2    Shah, P.K.3    Zhang, W.4    Yano, J.5    Doherty, T.M.6    Akira, S.7    Rajavashisth, T.B.8    Arditi, M.9
  • 92
    • 21944444926 scopus 로고    scopus 로고
    • Variation in the toll-like receptor 4 gene and susceptibility to myocardial infarction
    • Holloway JW, Yang IA, Ye S. Variation in the toll-like receptor 4 gene and susceptibility to myocardial infarction. Pharmacogenet Genomics. 2005;15:15-21.
    • (2005) Pharmacogenet Genomics , vol.15 , pp. 15-21
    • Holloway, J.W.1    Yang, I.A.2    Ye, S.3
  • 94
    • 0042194965 scopus 로고    scopus 로고
    • TLR4 Asp299Gly polymorphism is not associated with coronary artery stenosis
    • Yang IA, Holloway JW, Ye S. TLR4 Asp299Gly polymorphism is not associated with coronary artery stenosis. Atherosclerosis. 2003;170: 187-190.
    • (2003) Atherosclerosis , vol.170 , pp. 187-190
    • Yang, I.A.1    Holloway, J.W.2    Ye, S.3
  • 100
    • 0042734450 scopus 로고    scopus 로고
    • Oxidized phospholipid-induced endothelial cell/monocyte interaction is mediated by a cAMP-dependent R-Ras/PI3-kinase pathway
    • Cole AL, Subbanagounder G, Mukhopadhyay S, Berliner JA, Vora DK. Oxidized phospholipid-induced endothelial cell/monocyte interaction is mediated by a cAMP-dependent R-Ras/PI3-kinase pathway. Arterioscler Thromb Vasc Biol. 2003;23:1384-1390.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 1384-1390
    • Cole, A.L.1    Subbanagounder, G.2    Mukhopadhyay, S.3    Berliner, J.A.4    Vora, D.K.5
  • 102
    • 33947321122 scopus 로고    scopus 로고
    • Inflammatory profile of oxidized phospholipids
    • Bochkov VN. Inflammatory profile of oxidized phospholipids. Thromb Haemost. 2007;97:348-354.
    • (2007) Thromb Haemost , vol.97 , pp. 348-354
    • Bochkov, V.N.1
  • 103
    • 77951479702 scopus 로고    scopus 로고
    • Oxidized phospholipids regulate expression of ATF4 and VEGF in endothelial cells via NRF2-dependent mechanism: Novel point of convergence between electrophilic and unfolded protein stress pathways
    • Afonyushkin T, Oskolkova OV, Philippova M, Resink TJ, Erne P, Binder BR, Bochkov VN. Oxidized phospholipids regulate expression of ATF4 and VEGF in endothelial cells via NRF2-dependent mechanism: novel point of convergence between electrophilic and unfolded protein stress pathways. Arterioscler Thromb Vasc Biol. 2010;30: 1007-1013.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 1007-1013
    • Afonyushkin, T.1    Oskolkova, O.V.2    Philippova, M.3    Resink, T.J.4    Erne, P.5    Binder, B.R.6    Bochkov, V.N.7
  • 106
    • 47649102147 scopus 로고    scopus 로고
    • ATF4-dependent transcription is a key mechanism in VEGF up-regulation by oxidized phospholipids: Critical role of oxidized sn-2 residues in activation of unfolded protein response
    • Oskolkova OV, Afonyushkin T, Leitner A, von Schlieffen E, Gargalovic PS, Lusis AJ, Binder BR, Bochkov VN. ATF4-dependent transcription is a key mechanism in VEGF up-regulation by oxidized phospholipids: critical role of oxidized sn-2 residues in activation of unfolded protein response. Blood. 2008;112:330-339.
    • (2008) Blood , vol.112 , pp. 330-339
    • Oskolkova, O.V.1    Afonyushkin, T.2    Leitner, A.3    Von Schlieffen, E.4    Gargalovic, P.S.5    Lusis, A.J.6    Binder, B.R.7    Bochkov, V.N.8
  • 108
    • 0036141870 scopus 로고    scopus 로고
    • Oxidized membrane vesicles and blebs from apoptotic cells contain biologically active oxidized phospholipids that induce monocyte-endothelial interactions
    • Huber J, Vales A, Mitulovic G, Blumer M, Schmid R, Witztum JL, Binder BR, Leitinger N. Oxidized membrane vesicles and blebs from apoptotic cells contain biologically active oxidized phospholipids that induce monocyte-endothelial interactions. Arterioscler Thromb Vasc Biol. 2002;22:101-107.
    • (2002) Arterioscler Thromb Vasc Biol , vol.22 , pp. 101-107
    • Huber, J.1    Vales, A.2    Mitulovic, G.3    Blumer, M.4    Schmid, R.5    Witztum, J.L.6    Binder, B.R.7    Leitinger, N.8
  • 109
    • 0036774947 scopus 로고    scopus 로고
    • CD14 signalling in lipid rafts: New ligands and co-receptors
    • Schmitz G, Orso E. CD14 signalling in lipid rafts: new ligands and co-receptors. Curr Opin Lipidol. 2002;13:513-521.
    • (2002) Curr Opin Lipidol , vol.13 , pp. 513-521
    • Schmitz, G.1    Orso, E.2
  • 110
    • 59849086158 scopus 로고    scopus 로고
    • Macrophages generate reactive oxygen species in response to minimally oxidized low-density lipoprotein: Toll-like receptor 4-and spleen tyrosine kinase-dependent activation of NADPH oxidase 2
    • Bae YS, Lee JH, Choi SH, Kim S, Almazan F, Witztum JL, Miller YI. Macrophages generate reactive oxygen species in response to minimally oxidized low-density lipoprotein: Toll-like receptor 4-and spleen tyrosine kinase-dependent activation of NADPH oxidase 2. Circ Res. 2009;104:210-218.
    • (2009) Circ Res , vol.104 , pp. 210-218
    • Bae, Y.S.1    Lee, J.H.2    Choi, S.H.3    Kim, S.4    Almazan, F.5    Witztum, J.L.6    Miller, Y.I.7
  • 111
    • 77954762141 scopus 로고    scopus 로고
    • Low doses of lipopoly-saccharide and minimally oxidized low-density lipoprotein coopera tively activate macrophages via nuclear factor {kappa}B and activator protein-1. Possible mechanism for acceleration of atherosclerosis by subclinical endotoxemia
    • Wiesner P, Choi SH, Almazan F, Benner C, Huang W, Diehl CJ, Gonen A, Butler S, Witztum JL, Glass CK, Miller YI. Low doses of lipopoly-saccharide and minimally oxidized low-density lipoprotein coopera tively activate macrophages via nuclear factor {kappa}B and activator protein-1. Possible mechanism for acceleration of atherosclerosis by subclinical endotoxemia. Circ Res. 2010;107:56-65.
    • (2010) Circ Res , vol.107 , pp. 56-65
    • Wiesner, P.1    Choi, S.H.2    Almazan, F.3    Benner, C.4    Huang, W.5    Diehl, C.J.6    Gonen, A.7    Butler, S.8    Witztum, J.L.9    Glass, C.K.10    Miller, Y.I.11
  • 112
    • 65549163831 scopus 로고    scopus 로고
    • Glucose promotes membrane cholesterol crystalline domain formation by lipid peroxidation
    • Self-Medlin Y, Byun J, Jacob RF, Mizuno Y, Mason RP. Glucose promotes membrane cholesterol crystalline domain formation by lipid peroxidation. Biochim Biophys Acta. 2009;1788:1398-1403.
    • (2009) Biochim Biophys Acta , vol.1788 , pp. 1398-1403
    • Self-Medlin, Y.1    Byun, J.2    Jacob, R.F.3    Mizuno, Y.4    Mason, R.P.5
  • 114
  • 116
    • 33749147435 scopus 로고    scopus 로고
    • Passive immunization with monoclonal IgM antibodies against phosphorylcholine reduces accelerated vein graft atherosclerosis in apoli-poprotein E-null mice
    • Faria-Neto JR, Chyu KY, Li X, Dimayuga PC, Ferreira C, Yano J, Cercek B, Shah PK. Passive immunization with monoclonal IgM antibodies against phosphorylcholine reduces accelerated vein graft atherosclerosis in apoli-poprotein E-null mice. Atherosclerosis. 2006;189:83-90.
    • (2006) Atherosclerosis , vol.189 , pp. 83-90
    • Faria-Neto, J.R.1    Chyu, K.Y.2    Li, X.3    Dimayuga, P.C.4    Ferreira, C.5    Yano, J.6    Cercek, B.7    Shah, P.K.8
  • 118
    • 68249086404 scopus 로고    scopus 로고
    • Immunoglobulin M is required for protection against atherosclerosis in low-density lipoprotein receptor-deficient mice
    • Lewis MJ, Malik TH, Ehrenstein MR, Boyle JJ, Botto M, Haskard DO. Immunoglobulin M is required for protection against atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation. 2009;120: 417-426.
    • (2009) Circulation , vol.120 , pp. 417-426
    • Lewis, M.J.1    Malik, T.H.2    Ehrenstein, M.R.3    Boyle, J.J.4    Botto, M.5    Haskard, D.O.6
  • 119
    • 22144437349 scopus 로고    scopus 로고
    • IGM is required for efficient complement mediated phagocytosis of apoptotic cells in vivo
    • Ogden CA, Kowalewski R, Peng Y, Montenegro V, Elkon KB. IGM is required for efficient complement mediated phagocytosis of apoptotic cells in vivo. Autoimmunity. 2005;38:259-264.
    • (2005) Autoimmunity , vol.38 , pp. 259-264
    • Ogden, C.A.1    Kowalewski, R.2    Peng, Y.3    Montenegro, V.4    Elkon, K.B.5
  • 120
    • 70449710443 scopus 로고    scopus 로고
    • IgM antibodies to apoptosis-associated determinants recruit C1q and enhance dendritic cell phagocytosis of apoptotic cells
    • Chen Y, Park YB, Patel E, Silverman GJ. IgM antibodies to apoptosis-associated determinants recruit C1q and enhance dendritic cell phagocytosis of apoptotic cells. J Immunol. 2009;182:6031-6043.
    • (2009) J Immunol , vol.182 , pp. 6031-6043
    • Chen, Y.1    Park, Y.B.2    Patel, E.3    Silverman, G.J.4
  • 121
    • 4544261604 scopus 로고    scopus 로고
    • Percutaneous coronary intervention results in acute increases in oxidized phospholipids and lipoprotein(a): Short-term and long-term immunologic responses to oxidized low-density lipoprotein
    • Tsimikas S, Lau HK, Han KR, Shortal B, Miller ER, Segev A, Curtiss LK, Witztum JL, Strauss BH. Percutaneous coronary intervention results in acute increases in oxidized phospholipids and lipoprotein(a): short-term and long-term immunologic responses to oxidized low-density lipoprotein. Circulation. 2004;109: 3164-3170.
    • (2004) Circulation , vol.109 , pp. 3164-3170
    • Tsimikas, S.1    Lau, H.K.2    Han, K.R.3    Shortal, B.4    Miller, E.R.5    Segev, A.6    Curtiss, L.K.7    Witztum, J.L.8    Strauss, B.H.9
  • 125
    • 0036884424 scopus 로고    scopus 로고
    • A blast from the past: Clearance of apoptotic cells regulates immune responses
    • Savill J, Dransfield I, Gregory C, Haslett C. A blast from the past: clearance of apoptotic cells regulates immune responses. Nat Rev Immunol. 2002;2:965-975.
    • (2002) Nat Rev Immunol , vol.2 , pp. 965-975
    • Savill, J.1    Dransfield, I.2    Gregory, C.3    Haslett, C.4
  • 127
    • 67649668789 scopus 로고    scopus 로고
    • Transcrip-tional integration of TLR2 and TLR4 signaling at the NCoR dere-pression checkpoint
    • Huang W, Ghisletti S, Perissi V, Rosenfeld MG, Glass CK. Transcrip-tional integration of TLR2 and TLR4 signaling at the NCoR dere-pression checkpoint. Mol Cell. 2009;35:48-57.
    • (2009) Mol Cell , vol.35 , pp. 48-57
    • Huang, W.1    Ghisletti, S.2    Perissi, V.3    Rosenfeld, M.G.4    Glass, C.K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.