메뉴 건너뛰기




Volumn 21, Issue 5, 2009, Pages 257-264

Macrophage CD40 signaling: A pivotal regulator of disease protection and pathogenesis

Author keywords

CD154; CD40; Cell signaling; Inflammation; Macrophage; Monocyte

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; B7 ANTIGEN; CD40 ANTIGEN; CD40 LIGAND; CD40 LIGAND MONOCLONAL ANTIBODY; CD86 ANTIGEN; CYCLOOXYGENASE 2; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 12; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; STRESS ACTIVATED PROTEIN KINASE; SUPPRESSOR OF CYTOKINE SIGNALING 3; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 3; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 5; UNINDEXED DRUG;

EID: 70349141664     PISSN: 10445323     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.smim.2009.05.011     Document Type: Review
Times cited : (107)

References (112)
  • 1
    • 0014325451 scopus 로고
    • The origin and kinetics of mononuclear phagocytes
    • van Furth R., and Cohn Z.A. The origin and kinetics of mononuclear phagocytes. J Exp Med 128 (1968) 415-435
    • (1968) J Exp Med , vol.128 , pp. 415-435
    • van Furth, R.1    Cohn, Z.A.2
  • 2
    • 0015762998 scopus 로고
    • Quantitative study on the production and kinetics of mononuclear phagocytes during an acute inflammatory reaction
    • van Furth R., Diesselhoff-den Dulk M.C., and Mattie H. Quantitative study on the production and kinetics of mononuclear phagocytes during an acute inflammatory reaction. J Exp Med 138 (1973) 1314-1330
    • (1973) J Exp Med , vol.138 , pp. 1314-1330
    • van Furth, R.1    Diesselhoff-den Dulk, M.C.2    Mattie, H.3
  • 3
    • 0032411642 scopus 로고    scopus 로고
    • Mature monocytic cells enter tissues and engraft
    • Kennedy D.W., and Abkowitz J.L. Mature monocytic cells enter tissues and engraft. Proc Natl Acad Sci USA 95 (1998) 14944-14949
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 14944-14949
    • Kennedy, D.W.1    Abkowitz, J.L.2
  • 4
    • 0030787644 scopus 로고    scopus 로고
    • Kinetics of central nervous system microglial and macrophage engraftment: analysis using a transgenic bone marrow transplantation model
    • Kennedy D.W., and Abkowitz J.L. Kinetics of central nervous system microglial and macrophage engraftment: analysis using a transgenic bone marrow transplantation model. Blood 90 (1997) 986-993
    • (1997) Blood , vol.90 , pp. 986-993
    • Kennedy, D.W.1    Abkowitz, J.L.2
  • 5
    • 0034892257 scopus 로고    scopus 로고
    • Functional heterogeneity in liver and lung macrophages
    • Laskin D.L., Weinberger B., and Laskin J.D. Functional heterogeneity in liver and lung macrophages. J Leukoc Biol 70 (2001) 163-170
    • (2001) J Leukoc Biol , vol.70 , pp. 163-170
    • Laskin, D.L.1    Weinberger, B.2    Laskin, J.D.3
  • 6
    • 1542373666 scopus 로고    scopus 로고
    • Microglia, macrophages, perivascular macrophages, and pericytes: a review of function and identification
    • Guillemin G.J., and Brew B.J. Microglia, macrophages, perivascular macrophages, and pericytes: a review of function and identification. J Leukoc Biol 75 (2004) 388-397
    • (2004) J Leukoc Biol , vol.75 , pp. 388-397
    • Guillemin, G.J.1    Brew, B.J.2
  • 7
    • 23444437972 scopus 로고    scopus 로고
    • Structure and function of the spleen
    • Mebius R.E., and Kraal G. Structure and function of the spleen. Nat Rev Immunol 5 (2005) 606-616
    • (2005) Nat Rev Immunol , vol.5 , pp. 606-616
    • Mebius, R.E.1    Kraal, G.2
  • 8
    • 4344706372 scopus 로고    scopus 로고
    • Functional plasticity of macrophages: reversible adaptation to changing microenvironments
    • Stout R.D., and Suttles J. Functional plasticity of macrophages: reversible adaptation to changing microenvironments. J Leukoc Biol 76 (2004) 509-513
    • (2004) J Leukoc Biol , vol.76 , pp. 509-513
    • Stout, R.D.1    Suttles, J.2
  • 9
    • 0021751932 scopus 로고
    • Cell contact-mediated macrophage activation for antileishmanial defense. II. Identification of effector cell phenotype and genetic restriction
    • Sypek J.P., Panosian C.B., and Wyler D.J. Cell contact-mediated macrophage activation for antileishmanial defense. II. Identification of effector cell phenotype and genetic restriction. J Immunol 133 (1984) 3351-3357
    • (1984) J Immunol , vol.133 , pp. 3351-3357
    • Sypek, J.P.1    Panosian, C.B.2    Wyler, D.J.3
  • 10
    • 0024567163 scopus 로고
    • Antigen-specific activation of effector macrophages by IFN-gamma producing (TH1) T cell clones. Failure of IL-4-producing (TH2) T cell clones to activate effector function in macrophages
    • Stout R.D., and Bottomly K. Antigen-specific activation of effector macrophages by IFN-gamma producing (TH1) T cell clones. Failure of IL-4-producing (TH2) T cell clones to activate effector function in macrophages. J Immunol 142 (1989) 760-765
    • (1989) J Immunol , vol.142 , pp. 760-765
    • Stout, R.D.1    Bottomly, K.2
  • 11
    • 0026051961 scopus 로고
    • Antileishmanial defense in macrophages triggered by tumor necrosis factor expressed on CD4+ T lymphocyte plasma membrane
    • Sypek J.P., and Wyler D.J. Antileishmanial defense in macrophages triggered by tumor necrosis factor expressed on CD4+ T lymphocyte plasma membrane. J Exp Med 174 (1991) 755-759
    • (1991) J Exp Med , vol.174 , pp. 755-759
    • Sypek, J.P.1    Wyler, D.J.2
  • 12
    • 0027957017 scopus 로고
    • T cells which do not express membrane tumor necrosis factor-alpha activate macrophage effector function by cell contact-dependent signaling of macrophage tumor necrosis factor-alpha production
    • Suttles J., Miller R.W., Tao X., and Stout R.D. T cells which do not express membrane tumor necrosis factor-alpha activate macrophage effector function by cell contact-dependent signaling of macrophage tumor necrosis factor-alpha production. Eur J Immunol 24 (1994) 1736-1742
    • (1994) Eur J Immunol , vol.24 , pp. 1736-1742
    • Suttles, J.1    Miller, R.W.2    Tao, X.3    Stout, R.D.4
  • 13
    • 0027323354 scopus 로고
    • CD40 expression by human monocytes: regulation by cytokines and activation of monocytes by the ligand for CD40
    • Alderson M.R., Armitage R.J., Tough T.W., Strockbine L., Fanslow W.C., and Spriggs M.K. CD40 expression by human monocytes: regulation by cytokines and activation of monocytes by the ligand for CD40. J Exp Med 178 (1993) 669-674
    • (1993) J Exp Med , vol.178 , pp. 669-674
    • Alderson, M.R.1    Armitage, R.J.2    Tough, T.W.3    Strockbine, L.4    Fanslow, W.C.5    Spriggs, M.K.6
  • 14
    • 0028586815 scopus 로고
    • Role of the CD40-CD40 ligand interaction in CD4+ T cell contact-dependent activation of monocyte interleukin-1 synthesis
    • Wagner Jr. D.H., Stout R.D., and Suttles J. Role of the CD40-CD40 ligand interaction in CD4+ T cell contact-dependent activation of monocyte interleukin-1 synthesis. Eur J Immunol 24 (1994) 3148-3154
    • (1994) Eur J Immunol , vol.24 , pp. 3148-3154
    • Wagner Jr., D.H.1    Stout, R.D.2    Suttles, J.3
  • 15
    • 0028898462 scopus 로고
    • Activated T cells enhance nitric oxide production by murine splenic macrophages through gp39 and LFA-1
    • Tian L., Noelle R.J., and Lawrence D.A. Activated T cells enhance nitric oxide production by murine splenic macrophages through gp39 and LFA-1. Eur J Immunol 25 (1995) 306-309
    • (1995) Eur J Immunol , vol.25 , pp. 306-309
    • Tian, L.1    Noelle, R.J.2    Lawrence, D.A.3
  • 16
    • 0030028044 scopus 로고    scopus 로고
    • Impaired T cell-mediated macrophage activation in CD40 ligand-deficient mice
    • Stout R.D., Suttles J., Xu J., Grewal I.S., and Flavell R.A. Impaired T cell-mediated macrophage activation in CD40 ligand-deficient mice. J Immunol 156 (1996) 8-11
    • (1996) J Immunol , vol.156 , pp. 8-11
    • Stout, R.D.1    Suttles, J.2    Xu, J.3    Grewal, I.S.4    Flavell, R.A.5
  • 17
    • 0032484987 scopus 로고    scopus 로고
    • CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells
    • Henn V., Slupsky J.R., Grafe M., Anagnostopoulos I., Forster R., Muller-Berghaus G., et al. CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature 391 (1998) 591-594
    • (1998) Nature , vol.391 , pp. 591-594
    • Henn, V.1    Slupsky, J.R.2    Grafe, M.3    Anagnostopoulos, I.4    Forster, R.5    Muller-Berghaus, G.6
  • 18
    • 0027427165 scopus 로고
    • Induction of human IgE synthesis in B cells by mast cells and basophils
    • Gauchat J.F., Henchoz S., Mazzei G., Aubry J.P., Brunner T., Blasey H., et al. Induction of human IgE synthesis in B cells by mast cells and basophils. Nature 365 (1993) 340-343
    • (1993) Nature , vol.365 , pp. 340-343
    • Gauchat, J.F.1    Henchoz, S.2    Mazzei, G.3    Aubry, J.P.4    Brunner, T.5    Blasey, H.6
  • 19
    • 0035883087 scopus 로고    scopus 로고
    • The inflammatory action of CD40 ligand (CD154) expressed on activated human platelets is temporally limited by coexpressed CD40
    • Henn V., Steinbach S., Buchner K., Presek P., and Kroczek R.A. The inflammatory action of CD40 ligand (CD154) expressed on activated human platelets is temporally limited by coexpressed CD40. Blood 98 (2001) 1047-1054
    • (2001) Blood , vol.98 , pp. 1047-1054
    • Henn, V.1    Steinbach, S.2    Buchner, K.3    Presek, P.4    Kroczek, R.A.5
  • 20
    • 0035052821 scopus 로고    scopus 로고
    • Human lung tissue macrophages, but not alveolar macrophages, express matrix metalloproteinases after direct contact with activated T lymphocytes
    • Ferrari-Lacraz S., Nicod L.P., Chicheportiche R., Welgus H.G., and Dayer J.M. Human lung tissue macrophages, but not alveolar macrophages, express matrix metalloproteinases after direct contact with activated T lymphocytes. Am J Respir Cell Mol Biol 24 (2001) 442-451
    • (2001) Am J Respir Cell Mol Biol , vol.24 , pp. 442-451
    • Ferrari-Lacraz, S.1    Nicod, L.P.2    Chicheportiche, R.3    Welgus, H.G.4    Dayer, J.M.5
  • 21
    • 0028858649 scopus 로고
    • Stimulation of CD40 with purified soluble gp39 induces proinflammatory responses in human monocytes
    • Kiener P.A., Moran-Davis P., Rankin B.M., Wahl A.F., Aruffo A., and Hollenbaugh D. Stimulation of CD40 with purified soluble gp39 induces proinflammatory responses in human monocytes. J Immunol 155 (1995) 4917-4925
    • (1995) J Immunol , vol.155 , pp. 4917-4925
    • Kiener, P.A.1    Moran-Davis, P.2    Rankin, B.M.3    Wahl, A.F.4    Aruffo, A.5    Hollenbaugh, D.6
  • 22
    • 11844290745 scopus 로고    scopus 로고
    • TNF receptor-associated factor 6 is an essential mediator of CD40-activated proinflammatory pathways in monocytes and macrophages
    • Mukundan L., Bishop G.A., Head K.Z., Zhang L., Wahl L.M., and Suttles J. TNF receptor-associated factor 6 is an essential mediator of CD40-activated proinflammatory pathways in monocytes and macrophages. J Immunol 174 (2005) 1081-1090
    • (2005) J Immunol , vol.174 , pp. 1081-1090
    • Mukundan, L.1    Bishop, G.A.2    Head, K.Z.3    Zhang, L.4    Wahl, L.M.5    Suttles, J.6
  • 23
    • 0030064804 scopus 로고    scopus 로고
    • CD40/CD40 ligand interactions are required for T cell-dependent production of interleukin-12 by mouse macrophages
    • Kennedy M.K., Picha K.S., Fanslow W.C., Grabstein K.H., Alderson M.R., Clifford K.N., et al. CD40/CD40 ligand interactions are required for T cell-dependent production of interleukin-12 by mouse macrophages. Eur J Immunol 26 (1996) 370-378
    • (1996) Eur J Immunol , vol.26 , pp. 370-378
    • Kennedy, M.K.1    Picha, K.S.2    Fanslow, W.C.3    Grabstein, K.H.4    Alderson, M.R.5    Clifford, K.N.6
  • 24
    • 0028956699 scopus 로고
    • Activated T cells induce interleukin-12 production by monocytes via CD40-CD40 ligand interaction
    • Shu U., Kiniwa M., Wu C.Y., Maliszewski C., Vezzio N., Hakimi J., et al. Activated T cells induce interleukin-12 production by monocytes via CD40-CD40 ligand interaction. Eur J Immunol 25 (1995) 1125-1128
    • (1995) Eur J Immunol , vol.25 , pp. 1125-1128
    • Shu, U.1    Kiniwa, M.2    Wu, C.Y.3    Maliszewski, C.4    Vezzio, N.5    Hakimi, J.6
  • 25
    • 0032574782 scopus 로고    scopus 로고
    • CD40 ligand (CD154) stimulation of macrophages to produce HIV-1-suppressive beta-chemokines
    • Kornbluth R.S., Kee K., and Richman D.D. CD40 ligand (CD154) stimulation of macrophages to produce HIV-1-suppressive beta-chemokines. Proc Natl Acad Sci USA 95 (1998) 5205-5210
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 5205-5210
    • Kornbluth, R.S.1    Kee, K.2    Richman, D.D.3
  • 26
    • 0034708351 scopus 로고    scopus 로고
    • Induction and regulation of matrix metalloproteinase-12 by cytokines and CD40 signaling in monocyte/macrophages
    • Wu L., Fan J., Matsumoto S., and Watanabe T. Induction and regulation of matrix metalloproteinase-12 by cytokines and CD40 signaling in monocyte/macrophages. Biochem Biophys Res Commun 269 (2000) 808-815
    • (2000) Biochem Biophys Res Commun , vol.269 , pp. 808-815
    • Wu, L.1    Fan, J.2    Matsumoto, S.3    Watanabe, T.4
  • 27
    • 0029983775 scopus 로고    scopus 로고
    • Activation of human monocytes through CD40 induces matrix metalloproteinases
    • Malik N., Greenfield B.W., Wahl A.F., and Kiener P.A. Activation of human monocytes through CD40 induces matrix metalloproteinases. J Immunol 156 (1996) 3952-3960
    • (1996) J Immunol , vol.156 , pp. 3952-3960
    • Malik, N.1    Greenfield, B.W.2    Wahl, A.F.3    Kiener, P.A.4
  • 28
    • 0343742520 scopus 로고    scopus 로고
    • Activation of monocyte/macrophage functions related to acute atheroma complication by ligation of CD40: induction of collagenase, stromelysin, and tissue factor
    • Mach F., Schonbeck U., Bonnefoy J.Y., Pober J.S., and Libby P. Activation of monocyte/macrophage functions related to acute atheroma complication by ligation of CD40: induction of collagenase, stromelysin, and tissue factor. Circulation 96 (1997) 396-399
    • (1997) Circulation , vol.96 , pp. 396-399
    • Mach, F.1    Schonbeck, U.2    Bonnefoy, J.Y.3    Pober, J.S.4    Libby, P.5
  • 29
    • 0029848664 scopus 로고    scopus 로고
    • T cell rescue of monocytes from apoptosis: role of the CD40-CD40L interaction and requirement for CD40-mediated induction of protein tyrosine kinase activity
    • Suttles J., Evans M., Miller R.W., Poe J.C., Stout R.D., and Wahl L.M. T cell rescue of monocytes from apoptosis: role of the CD40-CD40L interaction and requirement for CD40-mediated induction of protein tyrosine kinase activity. J Leukoc Biol 60 (1996) 651-657
    • (1996) J Leukoc Biol , vol.60 , pp. 651-657
    • Suttles, J.1    Evans, M.2    Miller, R.W.3    Poe, J.C.4    Stout, R.D.5    Wahl, L.M.6
  • 30
    • 0027276691 scopus 로고
    • T cell-macrophage cognate interaction in the activation of macrophage effector function by Th2 cells
    • Stout R.D., and Suttles J. T cell-macrophage cognate interaction in the activation of macrophage effector function by Th2 cells. J Immunol 150 (1993) 5330-5337
    • (1993) J Immunol , vol.150 , pp. 5330-5337
    • Stout, R.D.1    Suttles, J.2
  • 31
    • 0033605124 scopus 로고    scopus 로고
    • CD40 signaling of monocyte inflammatory cytokine synthesis through an ERK1/2-dependent pathway. A target of interleukin (il)-4 and il-10 anti-inflammatory action
    • Suttles J., Milhorn D.M., Miller R.W., Poe J.C., Wahl L.M., and Stout R.D. CD40 signaling of monocyte inflammatory cytokine synthesis through an ERK1/2-dependent pathway. A target of interleukin (il)-4 and il-10 anti-inflammatory action. J Biol Chem 274 (1999) 5835-5842
    • (1999) J Biol Chem , vol.274 , pp. 5835-5842
    • Suttles, J.1    Milhorn, D.M.2    Miller, R.W.3    Poe, J.C.4    Wahl, L.M.5    Stout, R.D.6
  • 32
    • 18644379552 scopus 로고    scopus 로고
    • CD40 ligation activates murine macrophages via an IFN-gamma-dependent mechanism resulting in tumor cell destruction in vitro
    • Buhtoiarov I.N., Lum H., Berke G., Paulnock D.M., Sondel P.M., and Rakhmilevich A.L. CD40 ligation activates murine macrophages via an IFN-gamma-dependent mechanism resulting in tumor cell destruction in vitro. J Immunol 174 (2005) 6013-6022
    • (2005) J Immunol , vol.174 , pp. 6013-6022
    • Buhtoiarov, I.N.1    Lum, H.2    Berke, G.3    Paulnock, D.M.4    Sondel, P.M.5    Rakhmilevich, A.L.6
  • 33
    • 33746894598 scopus 로고    scopus 로고
    • In vivo CD40 ligation can induce T-cell-independent antitumor effects that involve macrophages
    • Lum H.D., Buhtoiarov I.N., Schmidt B.E., Berke G., Paulnock D.M., Sondel P.M., et al. In vivo CD40 ligation can induce T-cell-independent antitumor effects that involve macrophages. J Leukoc Biol 79 (2006) 1181-1192
    • (2006) J Leukoc Biol , vol.79 , pp. 1181-1192
    • Lum, H.D.1    Buhtoiarov, I.N.2    Schmidt, B.E.3    Berke, G.4    Paulnock, D.M.5    Sondel, P.M.6
  • 34
    • 33745542998 scopus 로고    scopus 로고
    • Generation of a multimeric form of CD40L with potent immunostimulatory activity using streptavidin as a chaperon
    • Kilinc M.O., Mukundan L., Yolcu E.S., Singh N.P., Suttles J., and Shirwan H. Generation of a multimeric form of CD40L with potent immunostimulatory activity using streptavidin as a chaperon. Exp Mol Pathol 80 (2006) 252-261
    • (2006) Exp Mol Pathol , vol.80 , pp. 252-261
    • Kilinc, M.O.1    Mukundan, L.2    Yolcu, E.S.3    Singh, N.P.4    Suttles, J.5    Shirwan, H.6
  • 35
    • 0035119146 scopus 로고    scopus 로고
    • CD40-mediated signaling in monocytic cells: up-regulation of tumor necrosis factor receptor-associated factor mRNAs and activation of mitogen-activated protein kinase signaling pathways
    • Pearson L.L., Castle B.E., and Kehry M.R. CD40-mediated signaling in monocytic cells: up-regulation of tumor necrosis factor receptor-associated factor mRNAs and activation of mitogen-activated protein kinase signaling pathways. Int Immunol 13 (2001) 273-283
    • (2001) Int Immunol , vol.13 , pp. 273-283
    • Pearson, L.L.1    Castle, B.E.2    Kehry, M.R.3
  • 36
    • 10744226270 scopus 로고    scopus 로고
    • Novel regulatory mechanisms of CD40-induced prostanoid synthesis by IL-4 and IL-10 in human monocytes
    • Inoue Y., Otsuka T., Niiro H., Nagano S., Arinobu Y., Ogami E., et al. Novel regulatory mechanisms of CD40-induced prostanoid synthesis by IL-4 and IL-10 in human monocytes. J Immunol 172 (2004) 2147-2154
    • (2004) J Immunol , vol.172 , pp. 2147-2154
    • Inoue, Y.1    Otsuka, T.2    Niiro, H.3    Nagano, S.4    Arinobu, Y.5    Ogami, E.6
  • 37
    • 2442635429 scopus 로고    scopus 로고
    • Reciprocal CD40 signals through p38MAPK and ERK-1/2 induce counteracting immune responses
    • Mathur R.K., Awasthi A., Wadhone P., Ramanamurthy B., and Saha B. Reciprocal CD40 signals through p38MAPK and ERK-1/2 induce counteracting immune responses. Nat Med 10 (2004) 540-544
    • (2004) Nat Med , vol.10 , pp. 540-544
    • Mathur, R.K.1    Awasthi, A.2    Wadhone, P.3    Ramanamurthy, B.4    Saha, B.5
  • 38
    • 0035930348 scopus 로고    scopus 로고
    • CD40 ligation induces macrophage IL-10 and TNF-alpha production: differential use of the PI3K and p42/44 MAPK-pathways
    • Foey A.D., Feldmann M., and Brennan F.M. CD40 ligation induces macrophage IL-10 and TNF-alpha production: differential use of the PI3K and p42/44 MAPK-pathways. Cytokine 16 (2001) 131-142
    • (2001) Cytokine , vol.16 , pp. 131-142
    • Foey, A.D.1    Feldmann, M.2    Brennan, F.M.3
  • 39
    • 23944486750 scopus 로고    scopus 로고
    • Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3
    • Martin M., Rehani K., Jope R.S., and Michalek S.M. Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3. Nat Immunol 6 (2005) 777-784
    • (2005) Nat Immunol , vol.6 , pp. 777-784
    • Martin, M.1    Rehani, K.2    Jope, R.S.3    Michalek, S.M.4
  • 40
    • 0042525945 scopus 로고    scopus 로고
    • Tpl2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40
    • Eliopoulos A.G., Wang C.C., Dumitru C.D., and Tsichlis P.N. Tpl2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40. EMBO J 22 (2003) 3855-3864
    • (2003) EMBO J , vol.22 , pp. 3855-3864
    • Eliopoulos, A.G.1    Wang, C.C.2    Dumitru, C.D.3    Tsichlis, P.N.4
  • 41
    • 0034627798 scopus 로고    scopus 로고
    • Tumor necrosis factor receptor-associated factor (TRAF) family: adapter proteins that mediate cytokine signaling
    • Inoue J., Ishida T., Tsukamoto N., Kobayashi N., Naito A., Azuma S., et al. Tumor necrosis factor receptor-associated factor (TRAF) family: adapter proteins that mediate cytokine signaling. Exp Cell Res 254 (2000) 14-24
    • (2000) Exp Cell Res , vol.254 , pp. 14-24
    • Inoue, J.1    Ishida, T.2    Tsukamoto, N.3    Kobayashi, N.4    Naito, A.5    Azuma, S.6
  • 42
    • 5044223172 scopus 로고    scopus 로고
    • The multifaceted roles of TRAFs in the regulation of B-cell function
    • Bishop G.A. The multifaceted roles of TRAFs in the regulation of B-cell function. Nat Rev Immunol 4 (2004) 775-786
    • (2004) Nat Rev Immunol , vol.4 , pp. 775-786
    • Bishop, G.A.1
  • 44
    • 0037352072 scopus 로고    scopus 로고
    • Distinct contributions of different CD40 TRAF binding sites to CD154-induced dendritic cell maturation and IL-12 secretion
    • Mackey M.F., Wang Z., Eichelberg K., and Germain R.N. Distinct contributions of different CD40 TRAF binding sites to CD154-induced dendritic cell maturation and IL-12 secretion. Eur J Immunol 33 (2003) 779-789
    • (2003) Eur J Immunol , vol.33 , pp. 779-789
    • Mackey, M.F.1    Wang, Z.2    Eichelberg, K.3    Germain, R.N.4
  • 45
    • 33748331335 scopus 로고    scopus 로고
    • CD40 induces macrophage anti-Toxoplasma gondii activity by triggering autophagy-dependent fusion of pathogen-containing vacuoles and lysosomes
    • Andrade R.M., Wessendarp M., Gubbels M.J., Striepen B., and Subauste C.S. CD40 induces macrophage anti-Toxoplasma gondii activity by triggering autophagy-dependent fusion of pathogen-containing vacuoles and lysosomes. J Clin Invest 116 (2006) 2366-2377
    • (2006) J Clin Invest , vol.116 , pp. 2366-2377
    • Andrade, R.M.1    Wessendarp, M.2    Gubbels, M.J.3    Striepen, B.4    Subauste, C.S.5
  • 46
    • 34248591490 scopus 로고    scopus 로고
    • CD40-TRAF6 and autophagy-dependent anti-microbial activity in macrophages
    • Subauste C.S., Andrade R.M., and Wessendarp M. CD40-TRAF6 and autophagy-dependent anti-microbial activity in macrophages. Autophagy 3 (2007) 245-248
    • (2007) Autophagy , vol.3 , pp. 245-248
    • Subauste, C.S.1    Andrade, R.M.2    Wessendarp, M.3
  • 47
    • 0033520080 scopus 로고    scopus 로고
    • High-affinity interactions of tumor necrosis factor receptor-associated factors (TRAFs) and CD40 require TRAF trimerization and CD40 multimerization
    • Pullen S.S., Labadia M.E., Ingraham R.H., McWhirter S.M., Everdeen D.S., Alber T., et al. High-affinity interactions of tumor necrosis factor receptor-associated factors (TRAFs) and CD40 require TRAF trimerization and CD40 multimerization. Biochemistry 38 (1999) 10168-10177
    • (1999) Biochemistry , vol.38 , pp. 10168-10177
    • Pullen, S.S.1    Labadia, M.E.2    Ingraham, R.H.3    McWhirter, S.M.4    Everdeen, D.S.5    Alber, T.6
  • 50
    • 0031570827 scopus 로고    scopus 로고
    • IL-4 and IL-10 modulation of CD40-mediated signaling of monocyte IL-1beta synthesis and rescue from apoptosis
    • Poe J.C., Wagner Jr. D.H., Miller R.W., Stout R.D., and Suttles J. IL-4 and IL-10 modulation of CD40-mediated signaling of monocyte IL-1beta synthesis and rescue from apoptosis. J Immunol 159 (1997) 846-852
    • (1997) J Immunol , vol.159 , pp. 846-852
    • Poe, J.C.1    Wagner Jr., D.H.2    Miller, R.W.3    Stout, R.D.4    Suttles, J.5
  • 51
    • 0035028784 scopus 로고    scopus 로고
    • CD40L-induced IL-12 production is further enhanced by the Th2 cytokines IL-4 and IL-13
    • Bullens D.M., Kasran A., Thielemans K., Bakkus M., and Ceuppens J.L. CD40L-induced IL-12 production is further enhanced by the Th2 cytokines IL-4 and IL-13. Scand J Immunol 53 (2001) 455-463
    • (2001) Scand J Immunol , vol.53 , pp. 455-463
    • Bullens, D.M.1    Kasran, A.2    Thielemans, K.3    Bakkus, M.4    Ceuppens, J.L.5
  • 52
    • 0037097509 scopus 로고    scopus 로고
    • Involvement of suppressor of cytokine signaling-3 as a mediator of the inhibitory effects of IL-10 on lipopolysaccharide-induced macrophage activation
    • Berlato C., Cassatella M.A., Kinjyo I., Gatto L., Yoshimura A., and Bazzoni F. Involvement of suppressor of cytokine signaling-3 as a mediator of the inhibitory effects of IL-10 on lipopolysaccharide-induced macrophage activation. J Immunol 168 (2002) 6404-6411
    • (2002) J Immunol , vol.168 , pp. 6404-6411
    • Berlato, C.1    Cassatella, M.A.2    Kinjyo, I.3    Gatto, L.4    Yoshimura, A.5    Bazzoni, F.6
  • 53
    • 33846523494 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling-1 is an IL-4-inducible gene in macrophages and feedback inhibits IL-4 signaling
    • Dickensheets H., Vazquez N., Sheikh F., Gingras S., Murray P.J., Ryan J.J., et al. Suppressor of cytokine signaling-1 is an IL-4-inducible gene in macrophages and feedback inhibits IL-4 signaling. Genes Immun 8 (2007) 21-27
    • (2007) Genes Immun , vol.8 , pp. 21-27
    • Dickensheets, H.1    Vazquez, N.2    Sheikh, F.3    Gingras, S.4    Murray, P.J.5    Ryan, J.J.6
  • 55
    • 58849115949 scopus 로고    scopus 로고
    • Adenosine 5′-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype
    • Sag D., Carling D., Stout R.D., and Suttles J. Adenosine 5′-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype. J Immunol 181 (2008) 8633-8641
    • (2008) J Immunol , vol.181 , pp. 8633-8641
    • Sag, D.1    Carling, D.2    Stout, R.D.3    Suttles, J.4
  • 56
    • 36049034344 scopus 로고    scopus 로고
    • Anti-inflammatory actions of PPAR ligands: new insights on cellular and molecular mechanisms
    • Straus D.S., and Glass C.K. Anti-inflammatory actions of PPAR ligands: new insights on cellular and molecular mechanisms. Trends Immunol 28 (2007) 551-558
    • (2007) Trends Immunol , vol.28 , pp. 551-558
    • Straus, D.S.1    Glass, C.K.2
  • 57
    • 16844379483 scopus 로고    scopus 로고
    • The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activities
    • Makowski L., Brittingham K.C., Reynolds J.M., Suttles J., and Hotamisligil G.S. The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activities. J Biol Chem 280 (2005) 12888-12895
    • (2005) J Biol Chem , vol.280 , pp. 12888-12895
    • Makowski, L.1    Brittingham, K.C.2    Reynolds, J.M.3    Suttles, J.4    Hotamisligil, G.S.5
  • 58
    • 0034672472 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma activators inhibit interleukin-12 production in murine dendritic cells
    • Faveeuw C., Fougeray S., Angeli V., Fontaine J., Chinetti G., Gosset P., et al. Peroxisome proliferator-activated receptor gamma activators inhibit interleukin-12 production in murine dendritic cells. FEBS Lett 486 (2000) 261-266
    • (2000) FEBS Lett , vol.486 , pp. 261-266
    • Faveeuw, C.1    Fougeray, S.2    Angeli, V.3    Fontaine, J.4    Chinetti, G.5    Gosset, P.6
  • 59
    • 41749102407 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein 1 and CD40 ligation have a synergistic effect on vascular endothelial growth factor production through cyclooxygenase 2 upregulation in gastric cancer
    • Futagami S., Tatsuguchi A., Hiratsuka T., Shindo T., Horie A., Hamamoto T., et al. Monocyte chemoattractant protein 1 and CD40 ligation have a synergistic effect on vascular endothelial growth factor production through cyclooxygenase 2 upregulation in gastric cancer. J Gastroenterol 43 (2008) 216-224
    • (2008) J Gastroenterol , vol.43 , pp. 216-224
    • Futagami, S.1    Tatsuguchi, A.2    Hiratsuka, T.3    Shindo, T.4    Horie, A.5    Hamamoto, T.6
  • 60
    • 0344825120 scopus 로고    scopus 로고
    • Molecular regulation of CD40 gene expression in macrophages and microglia
    • Benveniste E.N., Nguyen V.T., and Wesemann D.R. Molecular regulation of CD40 gene expression in macrophages and microglia. Brain Behav Immun 18 (2004) 7-12
    • (2004) Brain Behav Immun , vol.18 , pp. 7-12
    • Benveniste, E.N.1    Nguyen, V.T.2    Wesemann, D.R.3
  • 61
    • 0030272352 scopus 로고    scopus 로고
    • The many roles of CD40 in cell-mediated inflammatory responses
    • Stout R.D., and Suttles J. The many roles of CD40 in cell-mediated inflammatory responses. Immunol Today 17 (1996) 487-492
    • (1996) Immunol Today , vol.17 , pp. 487-492
    • Stout, R.D.1    Suttles, J.2
  • 62
    • 27644530602 scopus 로고    scopus 로고
    • LPS induces CD40 gene expression through the activation of NF-kappaB and STAT-1alpha in macrophages and microglia
    • Qin H., Wilson C.A., Lee S.J., Zhao X., and Benveniste E.N. LPS induces CD40 gene expression through the activation of NF-kappaB and STAT-1alpha in macrophages and microglia. Blood 106 (2005) 3114-3122
    • (2005) Blood , vol.106 , pp. 3114-3122
    • Qin, H.1    Wilson, C.A.2    Lee, S.J.3    Zhao, X.4    Benveniste, E.N.5
  • 63
    • 58149500153 scopus 로고    scopus 로고
    • Mechanisms of LPS-induced CD40 expression in human peripheral blood monocytic cells
    • Wu W., Alexis N.E., Bromberg P.A., Jaspers I., and Peden D.B. Mechanisms of LPS-induced CD40 expression in human peripheral blood monocytic cells. Biochem Biophys Res Commun 379 (2009) 573-577
    • (2009) Biochem Biophys Res Commun , vol.379 , pp. 573-577
    • Wu, W.1    Alexis, N.E.2    Bromberg, P.A.3    Jaspers, I.4    Peden, D.B.5
  • 64
    • 41549163407 scopus 로고    scopus 로고
    • Involvement of mitogen-activated protein kinases and NFkappaB in LPS-induced CD40 expression on human monocytic cells
    • Wu W., Alexis N.E., Chen X., Bromberg P.A., and Peden D.B. Involvement of mitogen-activated protein kinases and NFkappaB in LPS-induced CD40 expression on human monocytic cells. Toxicol Appl Pharmacol 228 (2008) 135-143
    • (2008) Toxicol Appl Pharmacol , vol.228 , pp. 135-143
    • Wu, W.1    Alexis, N.E.2    Chen, X.3    Bromberg, P.A.4    Peden, D.B.5
  • 65
    • 0031948066 scopus 로고    scopus 로고
    • Post-transcriptional inhibition of CD40 gene expression in microglia by transforming growth factor-beta
    • Nguyen V.T., Walker W.S., and Benveniste E.N. Post-transcriptional inhibition of CD40 gene expression in microglia by transforming growth factor-beta. Eur J Immunol 28 (1998) 2537-2548
    • (1998) Eur J Immunol , vol.28 , pp. 2537-2548
    • Nguyen, V.T.1    Walker, W.S.2    Benveniste, E.N.3
  • 66
    • 0034544564 scopus 로고    scopus 로고
    • IL-4-activated STAT-6 inhibits IFN-gamma-induced CD40 gene expression in macrophages/microglia
    • Nguyen V.T., and Benveniste E.N. IL-4-activated STAT-6 inhibits IFN-gamma-induced CD40 gene expression in macrophages/microglia. J Immunol 165 (2000) 6235-6243
    • (2000) J Immunol , vol.165 , pp. 6235-6243
    • Nguyen, V.T.1    Benveniste, E.N.2
  • 67
    • 33751555746 scopus 로고    scopus 로고
    • IL-10 inhibits lipopolysaccharide-induced CD40 gene expression through induction of suppressor of cytokine signaling-3
    • Qin H., Wilson C.A., Roberts K.L., Baker B.J., Zhao X., and Benveniste E.N. IL-10 inhibits lipopolysaccharide-induced CD40 gene expression through induction of suppressor of cytokine signaling-3. J Immunol 177 (2006) 7761-7771
    • (2006) J Immunol , vol.177 , pp. 7761-7771
    • Qin, H.1    Wilson, C.A.2    Roberts, K.L.3    Baker, B.J.4    Zhao, X.5    Benveniste, E.N.6
  • 68
    • 0035856535 scopus 로고    scopus 로고
    • Upregulation of CD40 and CD40 ligand (CD154) in patients with moderate hypercholesterolemia
    • Garlichs C.D., John S., Schmeisser A., Eskafi S., Stumpf C., Karl M., et al. Upregulation of CD40 and CD40 ligand (CD154) in patients with moderate hypercholesterolemia. Circulation 104 (2001) 2395-2400
    • (2001) Circulation , vol.104 , pp. 2395-2400
    • Garlichs, C.D.1    John, S.2    Schmeisser, A.3    Eskafi, S.4    Stumpf, C.5    Karl, M.6
  • 69
    • 0037038402 scopus 로고    scopus 로고
    • The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease
    • Youssef S., Stuve O., Patarroyo J.C., Ruiz P.J., Radosevich J.L., Hur E.M., et al. The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease. Nature 420 (2002) 78-84
    • (2002) Nature , vol.420 , pp. 78-84
    • Youssef, S.1    Stuve, O.2    Patarroyo, J.C.3    Ruiz, P.J.4    Radosevich, J.L.5    Hur, E.M.6
  • 70
    • 34547769908 scopus 로고    scopus 로고
    • Simvastatin inhibits IFN-gamma-induced CD40 gene expression by suppressing STAT-1alpha
    • Lee S.J., Qin H., and Benveniste E.N. Simvastatin inhibits IFN-gamma-induced CD40 gene expression by suppressing STAT-1alpha. J Leukoc Biol 82 (2007) 436-447
    • (2007) J Leukoc Biol , vol.82 , pp. 436-447
    • Lee, S.J.1    Qin, H.2    Benveniste, E.N.3
  • 72
    • 0027816953 scopus 로고
    • Prevention of collagen-induced arthritis with an antibody to gp39, the ligand for CD40
    • Durie F.H., Fava R.A., Foy T.M., Aruffo A., Ledbetter J.A., and Noelle R.J. Prevention of collagen-induced arthritis with an antibody to gp39, the ligand for CD40. Science 261 (1993) 1328-1330
    • (1993) Science , vol.261 , pp. 1328-1330
    • Durie, F.H.1    Fava, R.A.2    Foy, T.M.3    Aruffo, A.4    Ledbetter, J.A.5    Noelle, R.J.6
  • 73
    • 0031040964 scopus 로고    scopus 로고
    • Suppression of murine thyroiditis via blockade of the CD40-CD40L interaction
    • Carayanniotis G., Masters S.R., and Noelle R.J. Suppression of murine thyroiditis via blockade of the CD40-CD40L interaction. Immunology 90 (1997) 421-426
    • (1997) Immunology , vol.90 , pp. 421-426
    • Carayanniotis, G.1    Masters, S.R.2    Noelle, R.J.3
  • 74
    • 21244503823 scopus 로고    scopus 로고
    • Disruption of CD40/CD40-ligand interactions in a retinal autoimmunity model results in protection without tolerance
    • Bagenstose L.M., Agarwal R.K., Silver P.B., Harlan D.M., Hoffmann S.C., Kampen R.L., et al. Disruption of CD40/CD40-ligand interactions in a retinal autoimmunity model results in protection without tolerance. J Immunol 175 (2005) 124-130
    • (2005) J Immunol , vol.175 , pp. 124-130
    • Bagenstose, L.M.1    Agarwal, R.K.2    Silver, P.B.3    Harlan, D.M.4    Hoffmann, S.C.5    Kampen, R.L.6
  • 75
    • 0034665320 scopus 로고    scopus 로고
    • Amelioration of experimental autoimmune uveoretinitis by pretreatment with a pathogenic peptide in liposome and anti-CD40 ligand monoclonal antibody
    • Namba K., Ogasawara K., Kitaichi N., Morohashi T., Sasamoto Y., Kotake S., et al. Amelioration of experimental autoimmune uveoretinitis by pretreatment with a pathogenic peptide in liposome and anti-CD40 ligand monoclonal antibody. J Immunol 165 (2000) 2962-2969
    • (2000) J Immunol , vol.165 , pp. 2962-2969
    • Namba, K.1    Ogasawara, K.2    Kitaichi, N.3    Morohashi, T.4    Sasamoto, Y.5    Kotake, S.6
  • 76
    • 3042614161 scopus 로고    scopus 로고
    • The CD40/CD40L costimulatory pathway in inflammatory bowel disease
    • Danese S., Sans M., and Fiocchi C. The CD40/CD40L costimulatory pathway in inflammatory bowel disease. Gut 53 (2004) 1035-1043
    • (2004) Gut , vol.53 , pp. 1035-1043
    • Danese, S.1    Sans, M.2    Fiocchi, C.3
  • 77
    • 0031279105 scopus 로고    scopus 로고
    • CD40 ligand-CD40 interactions are necessary for the initiation of insulitis and diabetes in nonobese diabetic mice
    • Balasa B., Krahl T., Patstone G., Lee J., Tisch R., McDevitt H.O., et al. CD40 ligand-CD40 interactions are necessary for the initiation of insulitis and diabetes in nonobese diabetic mice. J Immunol 159 (1997) 4620-4627
    • (1997) J Immunol , vol.159 , pp. 4620-4627
    • Balasa, B.1    Krahl, T.2    Patstone, G.3    Lee, J.4    Tisch, R.5    McDevitt, H.O.6
  • 78
    • 0032953939 scopus 로고    scopus 로고
    • Mechanisms of immunotherapeutic intervention by anti-CD40L (CD154) antibody in an animal model of multiple sclerosis
    • Howard L.M., Miga A.J., Vanderlugt C.L., Dal Canto M.C., Laman J.D., Noelle R.J., et al. Mechanisms of immunotherapeutic intervention by anti-CD40L (CD154) antibody in an animal model of multiple sclerosis. J Clin Invest 103 (1999) 281-290
    • (1999) J Clin Invest , vol.103 , pp. 281-290
    • Howard, L.M.1    Miga, A.J.2    Vanderlugt, C.L.3    Dal Canto, M.C.4    Laman, J.D.5    Noelle, R.J.6
  • 79
    • 11944255564 scopus 로고    scopus 로고
    • Immunotherapy targeting the CD40/CD154 costimulatory pathway for treatment of autoimmune disease
    • Howard L.M., and Miller S.D. Immunotherapy targeting the CD40/CD154 costimulatory pathway for treatment of autoimmune disease. Autoimmunity 37 (2004) 411-418
    • (2004) Autoimmunity , vol.37 , pp. 411-418
    • Howard, L.M.1    Miller, S.D.2
  • 80
    • 0035896737 scopus 로고    scopus 로고
    • The clinical course of experimental autoimmune encephalomyelitis and inflammation is controlled by the expression of CD40 within the central nervous system
    • Becher B., Durell B.G., Miga A.V., Hickey W.F., and Noelle R.J. The clinical course of experimental autoimmune encephalomyelitis and inflammation is controlled by the expression of CD40 within the central nervous system. J Exp Med 193 (2001) 967-974
    • (2001) J Exp Med , vol.193 , pp. 967-974
    • Becher, B.1    Durell, B.G.2    Miga, A.V.3    Hickey, W.F.4    Noelle, R.J.5
  • 81
    • 31144457903 scopus 로고    scopus 로고
    • CD40 expression by microglial cells is required for their completion of a two-step activation process during central nervous system autoimmune inflammation
    • Ponomarev E.D., Shriver L.P., and Dittel B.N. CD40 expression by microglial cells is required for their completion of a two-step activation process during central nervous system autoimmune inflammation. J Immunol 176 (2006) 1402-1410
    • (2006) J Immunol , vol.176 , pp. 1402-1410
    • Ponomarev, E.D.1    Shriver, L.P.2    Dittel, B.N.3
  • 82
    • 54249160920 scopus 로고    scopus 로고
    • Cell signalling in macrophages, the principal innate immune effector cells of rheumatoid arthritis
    • Drexler S.K., Kong P.L., Wales J., and Foxwell B.M. Cell signalling in macrophages, the principal innate immune effector cells of rheumatoid arthritis. Arthritis Res Ther 10 (2008) 216
    • (2008) Arthritis Res Ther , vol.10 , pp. 216
    • Drexler, S.K.1    Kong, P.L.2    Wales, J.3    Foxwell, B.M.4
  • 83
    • 65249154820 scopus 로고    scopus 로고
    • Amphoteric liposomes enable systemic antigen-presenting cell-directed delivery of CD40 antisense and are therapeutically effective in experimental arthritis
    • Andreakos E., Rauchhaus U., Stavropoulos A., Endert G., Wendisch V., Benahmed A.S., et al. Amphoteric liposomes enable systemic antigen-presenting cell-directed delivery of CD40 antisense and are therapeutically effective in experimental arthritis. Arthritis Rheum 60 (2009) 994-1005
    • (2009) Arthritis Rheum , vol.60 , pp. 994-1005
    • Andreakos, E.1    Rauchhaus, U.2    Stavropoulos, A.3    Endert, G.4    Wendisch, V.5    Benahmed, A.S.6
  • 85
    • 33846783031 scopus 로고    scopus 로고
    • An interferon-gamma-producing Th1 subset is the major source of IL-17 in experimental autoimmune encephalitis
    • Suryani S., and Sutton I. An interferon-gamma-producing Th1 subset is the major source of IL-17 in experimental autoimmune encephalitis. J Neuroimmunol 183 (2007) 96-103
    • (2007) J Neuroimmunol , vol.183 , pp. 96-103
    • Suryani, S.1    Sutton, I.2
  • 87
    • 33745571976 scopus 로고    scopus 로고
    • The immune response in atherosclerosis: a double-edged sword
    • Hansson G.K., and Libby P. The immune response in atherosclerosis: a double-edged sword. Nat Rev Immunol 6 (2006) 508-519
    • (2006) Nat Rev Immunol , vol.6 , pp. 508-519
    • Hansson, G.K.1    Libby, P.2
  • 88
    • 0033870357 scopus 로고    scopus 로고
    • Analysis of CD154 and CD40 expression in native coronary atherosclerosis and transplant associated coronary artery disease
    • Szabolcs M.J., Cannon P.J., Thienel U., Chen R., Michler R.E., Chess L., et al. Analysis of CD154 and CD40 expression in native coronary atherosclerosis and transplant associated coronary artery disease. Virchows Arch 437 (2000) 149-159
    • (2000) Virchows Arch , vol.437 , pp. 149-159
    • Szabolcs, M.J.1    Cannon, P.J.2    Thienel, U.3    Chen, R.4    Michler, R.E.5    Chess, L.6
  • 89
    • 0345735394 scopus 로고    scopus 로고
    • CD40-mediated activation of vascular smooth muscle cell chemokine production through a Src-initiated, MAPK-dependent pathway
    • Mukundan L., Milhorn D.M., Matta B., and Suttles J. CD40-mediated activation of vascular smooth muscle cell chemokine production through a Src-initiated, MAPK-dependent pathway. Cell Signal 16 (2004) 375-384
    • (2004) Cell Signal , vol.16 , pp. 375-384
    • Mukundan, L.1    Milhorn, D.M.2    Matta, B.3    Suttles, J.4
  • 90
    • 0031049711 scopus 로고    scopus 로고
    • Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for CD40-CD40 ligand signaling in atherosclerosis
    • Mach F., Schonbeck U., Sukhova G.K., Bourcier T., Bonnefoy J.Y., Pober J.S., et al. Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for CD40-CD40 ligand signaling in atherosclerosis. Proc Natl Acad Sci USA 94 (1997) 1931-1936
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 1931-1936
    • Mach, F.1    Schonbeck, U.2    Sukhova, G.K.3    Bourcier, T.4    Bonnefoy, J.Y.5    Pober, J.S.6
  • 91
    • 0141892153 scopus 로고    scopus 로고
    • CD40 ligand is selectively expressed on CD4+ T cells and platelets: implications for CD40-CD40L signalling in atherosclerosis
    • Buchner K., Henn V., Grafe M., de Boer O.J., Becker A.E., and Kroczek R.A. CD40 ligand is selectively expressed on CD4+ T cells and platelets: implications for CD40-CD40L signalling in atherosclerosis. J Pathol 201 (2003) 288-295
    • (2003) J Pathol , vol.201 , pp. 288-295
    • Buchner, K.1    Henn, V.2    Grafe, M.3    de Boer, O.J.4    Becker, A.E.5    Kroczek, R.A.6
  • 92
    • 2642608661 scopus 로고    scopus 로고
    • Reduction of atherosclerosis in mice by inhibition of CD40 signalling
    • Mach F., Schonbeck U., Sukhova G.K., Atkinson E., and Libby P. Reduction of atherosclerosis in mice by inhibition of CD40 signalling. Nature 394 (1998) 200-203
    • (1998) Nature , vol.394 , pp. 200-203
    • Mach, F.1    Schonbeck, U.2    Sukhova, G.K.3    Atkinson, E.4    Libby, P.5
  • 95
    • 25444485654 scopus 로고    scopus 로고
    • Leukocyte CD40L deficiency affects the CD25(+) CD4 T cell population but does not affect atherosclerosis
    • Smook M.L., Heeringa P., Damoiseaux J.G., Daemen M.J., de Winther M.P., Gijbels M.J., et al. Leukocyte CD40L deficiency affects the CD25(+) CD4 T cell population but does not affect atherosclerosis. Atherosclerosis 183 (2005) 275-282
    • (2005) Atherosclerosis , vol.183 , pp. 275-282
    • Smook, M.L.1    Heeringa, P.2    Damoiseaux, J.G.3    Daemen, M.J.4    de Winther, M.P.5    Gijbels, M.J.6
  • 96
    • 34247527793 scopus 로고    scopus 로고
    • CD40 ligand mediates inflammation independently of CD40 by interaction with Mac-1
    • Zirlik A., Maier C., Gerdes N., MacFarlane L., Soosairajah J., Bavendiek U., et al. CD40 ligand mediates inflammation independently of CD40 by interaction with Mac-1. Circulation 115 (2007) 1571-1580
    • (2007) Circulation , vol.115 , pp. 1571-1580
    • Zirlik, A.1    Maier, C.2    Gerdes, N.3    MacFarlane, L.4    Soosairajah, J.5    Bavendiek, U.6
  • 98
    • 0031977605 scopus 로고    scopus 로고
    • The role of CD40/CD154 interactions in the priming, differentiation, and effector function of helper and cytotoxic T cells
    • Mackey M.F., Barth Jr. R.J., and Noelle R.J. The role of CD40/CD154 interactions in the priming, differentiation, and effector function of helper and cytotoxic T cells. J Leukoc Biol 63 (1998) 418-428
    • (1998) J Leukoc Biol , vol.63 , pp. 418-428
    • Mackey, M.F.1    Barth Jr., R.J.2    Noelle, R.J.3
  • 99
    • 58849137203 scopus 로고    scopus 로고
    • CD40-CD40L cross-talk integrates strong antigenic signals and microbial stimuli to induce development of IL-17-producing CD4+ T cells
    • Iezzi G., Sonderegger I., Ampenberger F., Schmitz N., Marsland B.J., and Kopf M. CD40-CD40L cross-talk integrates strong antigenic signals and microbial stimuli to induce development of IL-17-producing CD4+ T cells. Proc Natl Acad Sci USA 106 (2009) 876-881
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 876-881
    • Iezzi, G.1    Sonderegger, I.2    Ampenberger, F.3    Schmitz, N.4    Marsland, B.J.5    Kopf, M.6
  • 100
  • 101
    • 0029925517 scopus 로고    scopus 로고
    • Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infection
    • Soong L., Xu J.C., Grewal I.S., Kima P., Sun J., Longley B.J., et al. Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infection. Immunity 4 (1996) 263-273
    • (1996) Immunity , vol.4 , pp. 263-273
    • Soong, L.1    Xu, J.C.2    Grewal, I.S.3    Kima, P.4    Sun, J.5    Longley, B.J.6
  • 102
    • 0033066902 scopus 로고    scopus 로고
    • CD40 ligation prevents Trypanosoma cruzi infection through interleukin-12 upregulation
    • Chaussabel D., Jacobs F., de J.J., de V.M., Carlier Y., Thielemans K., et al. CD40 ligation prevents Trypanosoma cruzi infection through interleukin-12 upregulation. Infect Immun 67 (1999) 1929-1934
    • (1999) Infect Immun , vol.67 , pp. 1929-1934
    • Chaussabel, D.1    Jacobs, F.2    de, J.J.3    de, V.M.4    Carlier, Y.5    Thielemans, K.6
  • 103
    • 25444494964 scopus 로고    scopus 로고
    • Transfection of Trypanosoma cruzi with host CD40 ligand results in improved control of parasite infection
    • Chamekh M., Vercruysse V., Habib M., Lorent M., Goldman M., Allaoui A., et al. Transfection of Trypanosoma cruzi with host CD40 ligand results in improved control of parasite infection. Infect Immun 73 (2005) 6552-6561
    • (2005) Infect Immun , vol.73 , pp. 6552-6561
    • Chamekh, M.1    Vercruysse, V.2    Habib, M.3    Lorent, M.4    Goldman, M.5    Allaoui, A.6
  • 104
    • 34249790860 scopus 로고    scopus 로고
    • Cutting edge: small molecule CD40 ligand mimetics promote control of parasitemia and enhance T cells producing IFN-gamma during experimental Trypanosoma cruzi infection
    • Habib M., Rivas M.N., Chamekh M., Wieckowski S., Sun W., Bianco A., et al. Cutting edge: small molecule CD40 ligand mimetics promote control of parasitemia and enhance T cells producing IFN-gamma during experimental Trypanosoma cruzi infection. J Immunol 178 (2007) 6700-6704
    • (2007) J Immunol , vol.178 , pp. 6700-6704
    • Habib, M.1    Rivas, M.N.2    Chamekh, M.3    Wieckowski, S.4    Sun, W.5    Bianco, A.6
  • 105
    • 33644784692 scopus 로고    scopus 로고
    • CD40 restrains in vivo growth of Toxoplasma gondii independently of gamma interferon
    • Subauste C.S., and Wessendarp M. CD40 restrains in vivo growth of Toxoplasma gondii independently of gamma interferon. Infect Immun 74 (2006) 1573-1579
    • (2006) Infect Immun , vol.74 , pp. 1573-1579
    • Subauste, C.S.1    Wessendarp, M.2
  • 106
    • 27144543529 scopus 로고    scopus 로고
    • TNF receptor-associated factor 6-dependent CD40 signaling primes macrophages to acquire antimicrobial activity in response to TNF-alpha
    • Andrade R.M., Wessendarp M., Portillo J.A., Yang J.Q., Gomez F.J., Durbin J.E., et al. TNF receptor-associated factor 6-dependent CD40 signaling primes macrophages to acquire antimicrobial activity in response to TNF-alpha. J Immunol 175 (2005) 6014-6021
    • (2005) J Immunol , vol.175 , pp. 6014-6021
    • Andrade, R.M.1    Wessendarp, M.2    Portillo, J.A.3    Yang, J.Q.4    Gomez, F.J.5    Durbin, J.E.6
  • 108
    • 0036107635 scopus 로고    scopus 로고
    • CD40/CD40 ligand interactions in the host defense against disseminated Candida albicans infection: the role of macrophage-derived nitric oxide
    • Netea M.G., Meer J.W., Verschueren I., and Kullberg B.J. CD40/CD40 ligand interactions in the host defense against disseminated Candida albicans infection: the role of macrophage-derived nitric oxide. Eur J Immunol 32 (2002) 1455-1463
    • (2002) Eur J Immunol , vol.32 , pp. 1455-1463
    • Netea, M.G.1    Meer, J.W.2    Verschueren, I.3    Kullberg, B.J.4
  • 109
    • 0038781654 scopus 로고    scopus 로고
    • CD40 contributes to lethality in acute sepsis: in vivo role for CD40 in innate immunity
    • Gold J.A., Parsey M., Hoshino Y., Hoshino S., Nolan A., Yee H., et al. CD40 contributes to lethality in acute sepsis: in vivo role for CD40 in innate immunity. Infect Immun 71 (2003) 3521-3528
    • (2003) Infect Immun , vol.71 , pp. 3521-3528
    • Gold, J.A.1    Parsey, M.2    Hoshino, Y.3    Hoshino, S.4    Nolan, A.5    Yee, H.6
  • 110
    • 9644310303 scopus 로고    scopus 로고
    • Cd40 but not CD154 knockout mice have reduced inflammatory response in polymicrobial sepsis: a potential role for Escherichia coli heat shock protein 70 in CD40-mediated inflammation in vivo
    • Nolan A., Weiden M.D., Hoshino Y., and Gold J.A. Cd40 but not CD154 knockout mice have reduced inflammatory response in polymicrobial sepsis: a potential role for Escherichia coli heat shock protein 70 in CD40-mediated inflammation in vivo. Shock 22 (2004) 538-542
    • (2004) Shock , vol.22 , pp. 538-542
    • Nolan, A.1    Weiden, M.D.2    Hoshino, Y.3    Gold, J.A.4
  • 111
    • 18244367700 scopus 로고    scopus 로고
    • CD40 is a cellular receptor mediating mycobacterial heat shock protein 70 stimulation of CC-chemokines
    • Wang Y., Kelly C.G., Karttunen J.T., Whittall T., Lehner P.J., Duncan L., et al. CD40 is a cellular receptor mediating mycobacterial heat shock protein 70 stimulation of CC-chemokines. Immunity 15 (2001) 971-983
    • (2001) Immunity , vol.15 , pp. 971-983
    • Wang, Y.1    Kelly, C.G.2    Karttunen, J.T.3    Whittall, T.4    Lehner, P.J.5    Duncan, L.6
  • 112
    • 60749115540 scopus 로고    scopus 로고
    • Cholesterol depletion associated with Leishmania major infection alters macrophage CD40 signalosome composition and effector function
    • Rub A., Dey R., Jadhav M., Kamat R., Chakkaramakkil S., Majumdar S., et al. Cholesterol depletion associated with Leishmania major infection alters macrophage CD40 signalosome composition and effector function. Nat Immunol 10 (2009) 273-280
    • (2009) Nat Immunol , vol.10 , pp. 273-280
    • Rub, A.1    Dey, R.2    Jadhav, M.3    Kamat, R.4    Chakkaramakkil, S.5    Majumdar, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.