메뉴 건너뛰기




Volumn 119, Issue 11, 2016, Pages 1190-1203

Atherosclerosis-Driven Treg Plasticity Results in Formation of a Dysfunctional Subset of Plastic IFNγ+ Th1/Tregs

Author keywords

atherosclerosis; cell plasticity; immune system; immunology; inflammation; lymphocytes; Treg cells

Indexed keywords

ALPHA INTERFERON; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 7; T LYMPHOCYTE RECEPTOR;

EID: 84991435104     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.116.309764     Document Type: Article
Times cited : (146)

References (44)
  • 1
    • 84879569545 scopus 로고    scopus 로고
    • Immune effector mechanisms implicated in atherosclerosis: From mice to humans
    • Libby P, Lichtman AH, Hansson GK. Immune effector mechanisms implicated in atherosclerosis: from mice to humans. Immunity. 2013;38:1092-1104. doi: 10.1016/j.immuni.2013.06.009.
    • (2013) Immunity. , vol.38 , pp. 1092-1104
    • Libby, P.1    Lichtman, A.H.2    Hansson, G.K.3
  • 2
    • 67650720510 scopus 로고    scopus 로고
    • Immune and inflammatory mechanisms of atherosclerosis (∗)
    • Galkina E, Ley K. Immune and inflammatory mechanisms of atherosclerosis (∗). Annu Rev Immunol. 2009;27:165-197. doi: 10.1146/annurev. immunol.021908.132620.
    • (2009) Annu Rev Immunol. , vol.27 , pp. 165-197
    • Galkina, E.1    Ley, K.2
  • 4
    • 84874597449 scopus 로고    scopus 로고
    • Depletion of FOXP3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis
    • Klingenberg R, Gerdes N, Badeau RM, et al. Depletion of FOXP3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis. J Clin Invest. 2013;123:1323-1334. doi: 10.1172/JCI63891.
    • (2013) J Clin Invest. , vol.123 , pp. 1323-1334
    • Klingenberg, R.1    Gerdes, N.2    Badeau, R.M.3
  • 6
    • 36348967350 scopus 로고    scopus 로고
    • Low numbers of FOXP3 positive regulatory T cells are present in all developmental stages of human atherosclerotic lesions
    • de Boer OJ, van der Meer JJ, Teeling P, van der Loos CM, van der Wal AC. Low numbers of FOXP3 positive regulatory T cells are present in all developmental stages of human atherosclerotic lesions. PLoS One. 2007;2:e779. doi: 10.1371/journal.pone.0000779.
    • (2007) PLoS One. , vol.2 , pp. e779
    • De Boer, O.J.1    Van Der Meer, J.J.2    Teeling, P.3    Van Der Loos, C.M.4    Van Der Wal, A.C.5
  • 7
    • 79960410419 scopus 로고    scopus 로고
    • Dynamic changes in regulatory T cells are linked to levels of diet-induced hypercholesterolemia
    • Maganto-García E, Tarrio ML, Grabie N, Bu DX, Lichtman AH. Dynamic changes in regulatory T cells are linked to levels of diet-induced hypercholesterolemia. Circulation. 2011;124:185-195. doi: 10.1161/ CIRCULATIONAHA.110.006411.
    • (2011) Circulation. , vol.124 , pp. 185-195
    • Maganto-García, E.1    Tarrio, M.L.2    Grabie, N.3    Bu, D.X.4    Lichtman, A.H.5
  • 9
    • 84897946867 scopus 로고    scopus 로고
    • Once a Treg, always a Treg?
    • Sawant DV, Vignali DA. Once a Treg, always a Treg? Immunol Rev. 2014;259:173-191. doi: 10.1111/imr.12173.
    • (2014) Immunol Rev. , vol.259 , pp. 173-191
    • Sawant, D.V.1    Vignali, D.A.2
  • 10
    • 84897932501 scopus 로고    scopus 로고
    • Regulatory T-cell homeostasis: Steady-state maintenance and modulation during inflammation
    • Smigiel KS, Srivastava S, Stolley JM, Campbell DJ. Regulatory T-cell homeostasis: steady-state maintenance and modulation during inflammation. Immunol Rev. 2014;259:40-59. doi: 10.1111/imr.12170.
    • (2014) Immunol Rev. , vol.259 , pp. 40-59
    • Smigiel, K.S.1    Srivastava, S.2    Stolley, J.M.3    Campbell, D.J.4
  • 11
    • 84866483591 scopus 로고    scopus 로고
    • The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology
    • Hall AO, Beiting DP, Tato C, et al. The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology. Immunity. 2012;37:511-523. doi: 10.1016/j. immuni.2012.06.014.
    • (2012) Immunity. , vol.37 , pp. 511-523
    • Hall, A.O.1    Beiting, D.P.2    Tato, C.3
  • 12
    • 65749103365 scopus 로고    scopus 로고
    • The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
    • Koch MA, Tucker-Heard G, Perdue NR, Killebrew JR, Urdahl KB, Campbell DJ. The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat Immunol. 2009;10:595-602. doi: 10.1038/ni.1731.
    • (2009) Nat Immunol. , vol.10 , pp. 595-602
    • Koch, M.A.1    Tucker-Heard, G.2    Perdue, N.R.3    Killebrew, J.R.4    Urdahl, K.B.5    Campbell, D.J.6
  • 13
    • 84866499256 scopus 로고    scopus 로고
    • T-bet(+) Treg cells undergo abortive Th1 cell differentiation due to impaired expression of IL-12 receptor β2
    • Koch MA, Thomas KR, Perdue NR, Smigiel KS, Srivastava S, Campbell DJ. T-bet(+) Treg cells undergo abortive Th1 cell differentiation due to impaired expression of IL-12 receptor β2. Immunity. 2012;37:501-510. doi: 10.1016/j.immuni.2012.05.031.
    • (2012) Immunity. , vol.37 , pp. 501-510
    • Koch, M.A.1    Thomas, K.R.2    Perdue, N.R.3    Smigiel, K.S.4    Srivastava, S.5    Campbell, D.J.6
  • 19
    • 84930396449 scopus 로고    scopus 로고
    • MicroRNA regulation of lymphocyte tolerance and autoimmunity
    • Simpson LJ, Ansel KM. MicroRNA regulation of lymphocyte tolerance and autoimmunity. J Clin Invest. 2015;125:2242-2249. doi: 10.1172/JCI78090.
    • (2015) J Clin Invest. , vol.125 , pp. 2242-2249
    • Simpson, L.J.1    Ansel, K.M.2
  • 21
    • 84903185013 scopus 로고    scopus 로고
    • Single-cell RNA-seq reveals dynamic paracrine control of cellular variation
    • Shalek AK, Satija R, Shuga J, et al. Single-cell RNA-seq reveals dynamic paracrine control of cellular variation. Nature. 2014;510:363-369. doi: 10.1038/nature13437.
    • (2014) Nature. , vol.510 , pp. 363-369
    • Shalek, A.K.1    Satija, R.2    Shuga, J.3
  • 22
    • 80355136055 scopus 로고    scopus 로고
    • Flow cytometry analysis of immune cells within murine aortas
    • pii 2848
    • Butcher MJ, Herre M, Ley K, Galkina E. Flow cytometry analysis of immune cells within murine aortas. J Vis Exp. 2011;53. pii: 2848. doi: 10.3791/2848.
    • (2011) J Vis Exp. , vol.53
    • Butcher, M.J.1    Herre, M.2    Ley, K.3    Galkina, E.4
  • 23
    • 84857922610 scopus 로고    scopus 로고
    • The IL-17A/IL-17RA axis plays a proatherogenic role via the regulation of aortic myeloid cell recruitment
    • Butcher MJ, Gjurich BN, Phillips T, Galkina EV. The IL-17A/IL-17RA axis plays a proatherogenic role via the regulation of aortic myeloid cell recruitment. Circ Res. 2012;110:675-687. doi: 10.1161/ CIRCRESAHA.111.261784.
    • (2012) Circ Res. , vol.110 , pp. 675-687
    • Butcher, M.J.1    Gjurich, B.N.2    Phillips, T.3    Galkina, E.V.4
  • 24
  • 25
    • 84857416489 scopus 로고    scopus 로고
    • Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells
    • Miyao T, Floess S, Setoguchi R, Luche H, Fehling HJ, Waldmann H, Huehn J, Hori S. Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells. Immunity. 2012;36:262-275. doi: 10.1016/j.immuni.2011.12.012.
    • (2012) Immunity. , vol.36 , pp. 262-275
    • Miyao, T.1    Floess, S.2    Setoguchi, R.3    Luche, H.4    Fehling, H.J.5    Waldmann, H.6    Huehn, J.7    Hori, S.8
  • 26
    • 84922321862 scopus 로고    scopus 로고
    • Low-coverage single-cell mRNA sequencing reveals cellular heterogeneity and activated signaling pathways in developing cerebral cortex
    • Pollen AA, Nowakowski TJ, Shuga J, et al. Low-coverage single-cell mRNA sequencing reveals cellular heterogeneity and activated signaling pathways in developing cerebral cortex. Nat Biotechnol. 2014;32:1053-1058. doi: 10.1038/nbt.2967.
    • (2014) Nat Biotechnol. , vol.32 , pp. 1053-1058
    • Pollen, A.A.1    Nowakowski, T.J.2    Shuga, J.3
  • 28
    • 52949098296 scopus 로고    scopus 로고
    • Frequency-modulated nuclear localization bursts coordinate gene regulation
    • Cai L, Dalal CK, Elowitz MB. Frequency-modulated nuclear localization bursts coordinate gene regulation. Nature. 2008;455:485-490. doi: 10.1038/nature07292.
    • (2008) Nature. , vol.455 , pp. 485-490
    • Cai, L.1    Dalal, C.K.2    Elowitz, M.B.3
  • 29
    • 84898681799 scopus 로고    scopus 로고
    • Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses
    • Joller N, Lozano E, Burkett PR, et al. Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses. Immunity. 2014;40:569-581. doi: 10.1016/j.immuni.2014.02.012.
    • (2014) Immunity. , vol.40 , pp. 569-581
    • Joller, N.1    Lozano, E.2    Burkett, P.R.3
  • 31
    • 84923490401 scopus 로고    scopus 로고
    • Protein kinase CK2 enables regulatory T cells to suppress excessive TH2 responses in vivo
    • Ulges A, Klein M, Reuter S, et al. Protein kinase CK2 enables regulatory T cells to suppress excessive TH2 responses in vivo. Nat Immunol. 2015;16:267-275. doi: 10.1038/ni.3083.
    • (2015) Nat Immunol. , vol.16 , pp. 267-275
    • Ulges, A.1    Klein, M.2    Reuter, S.3
  • 33
    • 84860421960 scopus 로고    scopus 로고
    • Antiatherogenic effect of pioglitazone on uremic apolipoprotein E knockout mice by modulation of the balance of regulatory and effector T cells
    • Shen Y, Yuan Z, Yin A, Liu Y, Xiao Y, Wu Y, Wang L, Liang X, Zhao Y, Tian Y, Liu W, Chen T, Kishimoto C. Antiatherogenic effect of pioglitazone on uremic apolipoprotein E knockout mice by modulation of the balance of regulatory and effector T cells. Atherosclerosis. 2011;218:330-338. doi: 10.1016/j.atherosclerosis.2011.07.112.
    • (2011) Atherosclerosis. , vol.218 , pp. 330-338
    • Shen, Y.1    Yuan, Z.2    Yin, A.3    Liu, Y.4    Xiao, Y.5    Wu, Y.6    Wang, L.7    Liang, X.8    Zhao, Y.9    Tian, Y.10    Liu, W.11    Chen, T.12    Kishimoto, C.13
  • 35
    • 84941739398 scopus 로고    scopus 로고
    • Origin and functions of pro-inflammatory cytokine producing Foxp3+ regulatory T cells
    • Pandiyan P, Zhu J. Origin and functions of pro-inflammatory cytokine producing Foxp3+ regulatory T cells. Cytokine. 2015;76:13-24. doi: 10.1016/j.cyto.2015.07.005.
    • (2015) Cytokine. , vol.76 , pp. 13-24
    • Pandiyan, P.1    Zhu, J.2
  • 39
    • 85027951331 scopus 로고    scopus 로고
    • Adaptive immunity in atherosclerosis: Mechanisms and future therapeutic targets
    • Lahoute C, Herbin O, Mallat Z, Tedgui A. Adaptive immunity in atherosclerosis: mechanisms and future therapeutic targets. Nat Rev Cardiol. 2011;8:348-358. doi: 10.1038/nrcardio.2011.62.
    • (2011) Nat Rev Cardiol. , vol.8 , pp. 348-358
    • Lahoute, C.1    Herbin, O.2    Mallat, Z.3    Tedgui, A.4
  • 41
    • 84959539367 scopus 로고    scopus 로고
    • Harnessing the plasticity of CD4(+) T cells to treat immune-mediated disease
    • DuPage M, Bluestone JA. Harnessing the plasticity of CD4(+) T cells to treat immune-mediated disease. Nat Rev Immunol. 2016;16:149-163. doi: 10.1038/nri.2015.18.
    • (2016) Nat Rev Immunol. , vol.16 , pp. 149-163
    • DuPage, M.1    Bluestone, J.A.2
  • 42
    • 64549126102 scopus 로고    scopus 로고
    • Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells
    • Eid RE, Rao DA, Zhou J, Lo SF, Ranjbaran H, Gallo A, Sokol SI, Pfau S, Pober JS, Tellides G. Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells. Circulation. 2009;119:1424-1432. doi: 10.1161/CIRCULATIONAHA.108.827618.
    • (2009) Circulation. , vol.119 , pp. 1424-1432
    • Eid, R.E.1    Rao, D.A.2    Zhou, J.3    Lo, S.F.4    Ranjbaran, H.5    Gallo, A.6    Sokol, S.I.7    Pfau, S.8    Pober, J.S.9    Tellides, G.10
  • 43
    • 84878997106 scopus 로고    scopus 로고
    • Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells
    • Shalek AK, Satija R, Adiconis X, et al. Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells. Nature. 2013;498:236-240. doi: 10.1038/nature12172.
    • (2013) Nature. , vol.498 , pp. 236-240
    • Shalek, A.K.1    Satija, R.2    Adiconis, X.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.