Contributions of PD-1/PD-L1 pathway to interactions of myeloid DCs with T cells in atherosclerosis

Journal of Molecular and Cellular Cardiology

Volumn 46, Issue 2, 2009, Pages 169-176

  Lee, Jun ^a   Zhuang, Yan ^a   Wei, Xin ^a   Shang, Fujun ^a   Wang, Jiuping ^a   Zhang, Ye ^a   Liu, Xiongtao ^a   Yang, Yuhui ^a   Liu, Li ^a   Zheng, Qiangsun ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Atherosclerosis; Interferon; Myloid dendritic cell; Programmed death 1; Programmed death ligand 1

Indexed keywords

CD28 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2; PROGRAMMED DEATH 1; PROGRAMMED DEATH LIGAND 1; UNCLASSIFIED DRUG;

ADULT; ANTIGEN PRESENTING CELL; ARTICLE; ATHEROSCLEROSIS; BONE MARROW CELL; CELL INTERACTION; CELL PROLIFERATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CYTOKINE PRODUCTION; DENDRITIC CELL; DOWN REGULATION; FEMALE; FLOW CYTOMETRY; HUMAN; IMMUNOTHERAPY; MAJOR CLINICAL STUDY; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

AGED; ANTIGENS, CD; APOPTOSIS REGULATORY PROTEINS; ATHEROSCLEROSIS; CASE-CONTROL STUDIES; CELL COMMUNICATION; DENDRITIC CELLS; FEMALE; FLOW CYTOMETRY; HUMANS; INTERFERON-ALPHA; MALE; MIDDLE AGED; MYELOID CELLS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 58149461844     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2008.10.028     Document Type: Article

References (32)

1. Reiss A.B., and Glass A.D. Atherosclerosis: immune and inflammatory aspects. J. Investig. Med. 54 3 (2006 Apr) 123-131
2. Wick G., Knoflach M., and Xu Q. Autoimmune and inflammatory mechanisms in atherosclerosis. Annu. Rev. Immunol. 22 (2004) 361-403
3. Sharpe A.H., and Freeman G.J. The B7-CD28 superfamily. Nat. Rev. 2 2 (2002 Feb) 116-126
4. Greenwald R.J., Freeman G.J., and Sharpe A.H. The B7 family revisited. Annu. Rev. Immunol. 23 (2005) 515-548
5. Dong H., Zhu G., Tamada K., and Chen L. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat. Med. 5 12 (1999 Dec) 1365-1369
6. Keir M.E., Francisco L.M., and Sharpe A.H. PD-1 and its ligands in T-cell immunity. Curr. Opin. Immunol 19 3 (2007 Jun) 309-314
7. Latchman Y., Wood C.R., Chernova T., Chaudhary D., Borde M., Chernova I., et al. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat. Immunol 2 3 (2001 Mar) 261-268
8. Gotsman I., Grabie N., Dacosta R., Sukhova G., Sharpe A., and Lichtman A.H. Proatherogenic immune responses are regulated by the PD-1/PD-L pathway in mice. J. Clin. Invest. 117 10 (2007 Oct) 2974-2982
9. Hansson G.K. Immune mechanisms in atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 21 12 (2001 Dec) 1876-1890
10. Liu Y.J. Dendritic cell subsets and lineages, and their functions in innate and adaptive immunity. Cell 106 3 (2001 Aug 10) 259-262
11. Ponsaerts P., Van den Bosch G., Cools N., Van Driessche A., Nijs G., Lenjou M., et al. Messenger RNA electroporation of human monocytes, followed by rapid in vitro differentiation, leads to highly stimulatory antigen-loaded mature dendritic cells. J. Immunol. 169 4 (2002 Aug 15) 1669-1675
12. Patel T.N., Shishehbor M.H., and Bhatt D.L. A review of high-dose statin therapy: targeting cholesterol and inflammation in atherosclerosis. Eur. Heart J 28 6 (2007 Mar) 664-672
13. Khan Q., and Mehta J.L. Relevance of platelet-independent effects of aspirin to its salutary effect in atherosclerosis-related events. J. Atheroscler. Thromb. 12 4 (2005) 185-190
14. Chen L., Zhang Z., Chen W., Zhang Z., Li Y., Shi M., et al. B7-H1 up-regulation on myeloid dendritic cells significantly suppresses T cell immune function in patients with chronic hepatitis B. J. Immunol. 178 10 (2007 May 15) 6634-6641
15. Ross R. Atherosclerosis-an inflammatory disease. N. Engl. J. Med. 340 2 (1999 Jan 14) 115-126
16. Watts T.H. TNF/TNFR family members in costimulation of T cell responses. Annu. Rev. Immunol. 23 (2005) 23-68
17. Nishimura H., and Honjo T. PD-1: an inhibitory immunoreceptor involved in peripheral tolerance. Trends Immunol. 22 5 (2001 May) 265-268
18. Okazaki T., Iwai Y., and Honjo T. New regulatory co-receptors: inducible co-stimulator and PD-1. Curr. Opin. Immunol. 14 6 (2002 Dec) 779-782
19. Grakoui A., John Wherry E., Hanson H.L., Walker C., and Ahmed R. Turning on the off switch: regulation of anti-viral T cell responses in the liver by the PD-1/PD-L1 pathway. J. Hepatol. 45 4 (2006 Oct) 468-472
20. Rini B.I. Current status and future directions of molecular markers in renal cell carcinoma. Curr. Opin. Urol 16 5 (2006 Sep) 332-336
21. Dong H., and Chen X. Immunoregulatory role of B7-H1 in chronicity of inflammatory responses. Cell. Mol. Immunol 3 3 (2006 Jun) 179-187
22. Freeman G.J., Wherry E.J., Ahmed R., and Sharpe A.H. Reinvigorating exhausted HIV-specific T cells via PD-1-PD-1 ligand blockade. J. Exp. Med. 203 10 (2006 Oct 2) 2223-2227
23. Freeman G.J., Long A.J., Iwai Y., Bourque K., Chernova T., Nishimura H., et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J. Exp. Med. 192 7 (2000 Oct 2) 1027-1034
24. Szodoray P., Timar O., Veres K., Der H., Szomjak E., Lakos G., et al. TH1/TH2 imbalance, measured by circulating and intracytoplasmic inflammatory cytokines-immunological alterations in acute coronary syndrome and stable coronary artery disease. Scand. J. Immunol 64 3 (2006 Sep) 336-344
25. Fernandes J.L., Mamoni R.L., Orford J.L., Garcia C., Selwyn A.P., Coelho O.R., et al. Increased Th1 activity in patients with coronary artery disease. Cytokine 26 3 (2004 May 7) 131-137
26. Tedgui A., and Mallat Z. Cytokines in atherosclerosis: pathogenic and regulatory pathways. Physiol. Rev. 86 2 (2006 Apr) 515-581
27. Binder C.J., Chang M.K., Shaw P.X., Miller Y.I., Hartvigsen K., Dewan A., et al. Innate and acquired immunity in atherogenesis. Nat. Med. 8 11 (2002 Nov) 1218-1226
28. Veillard N.R., Steffens S., Burger F., Pelli G., and Mach F. Differential expression patterns of proinflammatory and antiinflammatory mediators during atherogenesis in mice. Arterioscler. Thromb. Vasc. Biol. 24 12 (2004 Dec) 2339-2344
29. Muhlbauer M., Fleck M., Schutz C., Weiss T., Froh M., Blank C., et al. PD-L1 is induced in hepatocytes by viral infection and by interferon-alpha and -gamma and mediates T cell apoptosis. J. Hepatol. 45 4 (2006 Oct) 520-528
30. Mazanet M.M., and Hughes C.C. B7-H1 is expressed by human endothelial cells and suppresses T cell cytokine synthesis. J. Immunol. 169 7 (2002 Oct 1) 3581-3588
31. Krakowski M., and Owens T. Interferon-gamma confers resistance to experimental allergic encephalomyelitis. Eur. J. Immunol 26 7 (1996 Jul) 1641-1646
32. Townsend M.J., and McKenzie A.N. Unravelling the net? Cytokines and diseases. J. Cell Sci. 113 Pt 20 (2000 Oct) 3549-3550