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Volumn 97, Issue 2, 2013, Pages 349-359

CTLA4-IgG ameliorates homocysteine-accelerated atherosclerosis by inhibiting T-cell overactivation in apoE-/- mice

Author keywords

Atherosclerosis; CTLA4 IgG; Homocysteine; Overactivation; T cell

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ABATACEPT; APOLIPOPROTEIN E; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; HOMOCYSTEINE; IMMUNOGLOBULIN G;

EID: 84872590494     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvs330     Document Type: Article
Times cited : (74)

References (45)
  • 1
    • 67650720510 scopus 로고    scopus 로고
    • Immune and inflammatory mechanisms of atherosclerosis (*)
    • Galkina E, Ley K. Immune and inflammatory mechanisms of atherosclerosis (*). Annu Rev Immunol 2009;27:165-197.
    • (2009) Annu Rev Immunol , vol.27 , pp. 165-197
    • Galkina, E.1    Ley, K.2
  • 3
    • 0036181860 scopus 로고    scopus 로고
    • Early inflammatory-immunological lesions in juvenile atherosclerosis from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY)-study
    • Millonig G, Malcom GT, Wick G. Early inflammatory-immunological lesions in juvenile atherosclerosis from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY)-study. Atherosclerosis 2002;160:441-448.
    • (2002) Atherosclerosis , vol.160 , pp. 441-448
    • Millonig, G.1    Malcom, G.T.2    Wick, G.3
  • 4
    • 70449715303 scopus 로고    scopus 로고
    • Regulatory T cells ameliorate hyperhomocysteinaemia-accelerated atherosclerosis in apo E2/2 mice
    • Feng J, Zhang Z, Kong W, Liu B, Xu Q, Wang X. Regulatory T cells ameliorate hyperhomocysteinaemia-accelerated atherosclerosis in apo E2/2 mice. Cardiovasc Res 2009;84:155-163.
    • (2009) Cardiovasc Res , vol.84 , pp. 155-163
    • Feng, J.1    Zhang, Z.2    Kong, W.3    Liu, B.4    Xu, Q.5    Wang, X.6
  • 5
    • 0036197073 scopus 로고    scopus 로고
    • Oxidant stress mechanism of homocysteine potentiating Con A-induced proliferation in murine splenic T lymphocytes
    • Zhang Q, Zeng X, Guo J, Wang X. Oxidant stress mechanism of homocysteine potentiating Con A-induced proliferation in murine splenic T lymphocytes. Cardiovasc Res 2002;53:1035-1042.
    • (2002) Cardiovasc Res , vol.53 , pp. 1035-1042
    • Zhang, Q.1    Zeng, X.2    Guo, J.3    Wang, X.4
  • 7
    • 0037080960 scopus 로고    scopus 로고
    • The two-signal model of T-cell activation after 30 years
    • Bernard A, Lamy AL, Alberti I. The two-signal model of T-cell activation after 30 years. Transplantation 2002;73:S31-35.
    • (2002) Transplantation , vol.73
    • Bernard, A.1    Lamy, A.L.2    Alberti, I.3
  • 9
    • 79955529454 scopus 로고    scopus 로고
    • Transendocytosis of CD80 and CD86: A molecular basis for the cell-extrinsic function of CTLA-4
    • Qureshi OS, Zheng Y, Nakamura K, Attridge K, Manzotti C, Schmidt EM et al. Transendocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. Science 2011;332:600-603.
    • (2011) Science , vol.332 , pp. 600-603
    • Qureshi, O.S.1    Zheng, Y.2    Nakamura, K.3    Attridge, K.4    Manzotti, C.5    Schmidt, E.M.6
  • 10
    • 0034327809 scopus 로고    scopus 로고
    • Regulation of cell surface expression of CTLA-4 by secretion of CTLA-4-containing lysosomes upon activation of CD4+ T cells
    • Iida T, Ohno H, Nakaseko C, Sakuma M, Takeda-Ezaki M, Arase H et al. Regulation of cell surface expression of CTLA-4 by secretion of CTLA-4-containing lysosomes upon activation of CD4+ T cells. J Immunol 2000;165:5062-5068.
    • (2000) J Immunol , vol.165 , pp. 5062-5068
    • Iida, T.1    Ohno, H.2    Nakaseko, C.3    Sakuma, M.4    Takeda-Ezaki, M.5    Arase, H.6
  • 11
    • 0031181647 scopus 로고    scopus 로고
    • Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression
    • Chuang E, Alegre ML, Duckett CS, Noel PJ, Vander Heiden MG, Thompson CB. Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression. J Immunol 1997; 159:144-151.
    • (1997) J Immunol , vol.159 , pp. 144-151
    • Chuang, E.1    Alegre, M.L.2    Duckett, C.S.3    Noel, P.J.4    Vander Heiden, M.G.5    Thompson, C.B.6
  • 12
    • 77957839110 scopus 로고    scopus 로고
    • Selective co-stimulation blockade. CTLA4-Ig (Abatacept)
    • Alten R, Marker-Hermann E. [Selective co-stimulation blockade. CTLA4-Ig (Abatacept)]. Z Rheumatol 2010;69:601-607.
    • (2010) Z Rheumatol , vol.69 , pp. 601-607
    • Alten, R.1    Marker-Hermann, E.2
  • 13
    • 0032490620 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28
    • Lin H, Rathmell JC, Gray GS, Thompson CB, Leiden JM, Alegre ML. Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28. J Exp Med 1998;188:199-204.
    • (1998) J Exp Med , vol.188 , pp. 199-204
    • Lin, H.1    Rathmell, J.C.2    Gray, G.S.3    Thompson, C.B.4    Leiden, J.M.5    Alegre, M.L.6
  • 14
    • 0032037509 scopus 로고    scopus 로고
    • CTLA4Ig inhibits airway eosinophilia and hyperresponsiveness by regulating the development of Th1/Th2 subsets in a murine model of asthma
    • Padrid PA, Mathur M, Li X, Herrmann K, Qin Y, Cattamanchi A et al. CTLA4Ig inhibits airway eosinophilia and hyperresponsiveness by regulating the development of Th1/Th2 subsets in a murine model of asthma. Am J Resp Cell Mol Biol 1998;18:453-462.
    • (1998) Am J Resp Cell Mol Biol , vol.18 , pp. 453-462
    • Padrid, P.A.1    Mathur, M.2    Li, X.3    Herrmann, K.4    Qin, Y.5    Cattamanchi, A.6
  • 15
    • 0037083423 scopus 로고    scopus 로고
    • Mechanism of action of combined short-term CTLA4Ig and anti-CD40 ligand in murine systemic lupus erythematosus
    • Wang X, Huang W, Mihara M, Sinha J, Davidson A. Mechanism of action of combined short-term CTLA4Ig and anti-CD40 ligand in murine systemic lupus erythematosus. J Immunol 2002;168:2046-2053.
    • (2002) J Immunol , vol.168 , pp. 2046-2053
    • Wang, X.1    Huang, W.2    Mihara, M.3    Sinha, J.4    Davidson, A.5
  • 16
    • 17044429848 scopus 로고    scopus 로고
    • Exocytosis of CTLA-4 is dependent on phospholipase D and ADP ribosylation factor-1 and stimulated during activation of regulatory T cells
    • Mead KI, Zheng Y, Manzotti CN, Perry LC, Liu MK, Burke F et al. Exocytosis of CTLA-4 is dependent on phospholipase D and ADP ribosylation factor-1 and stimulated during activation of regulatory T cells. J Immunol 2005;174:4803-4811.
    • (2005) J Immunol , vol.174 , pp. 4803-4811
    • Mead, K.I.1    Zheng, Y.2    Manzotti, C.N.3    Perry, L.C.4    Liu, M.K.5    Burke, F.6
  • 17
    • 79952071002 scopus 로고    scopus 로고
    • A novel mechanism of gamma/delta T-lymphocyte and endothelial activation by shear stress: The role of ecto-ATP synthase beta chain
    • Fu Y, Hou Y, Fu C, Gu M, Li C, Kong W et al. A novel mechanism of gamma/delta T-lymphocyte and endothelial activation by shear stress: the role of ecto-ATP synthase beta chain. Circ Res 2011;108:410-417.
    • (2011) Circ Res , vol.108 , pp. 410-417
    • Fu, Y.1    Hou, Y.2    Fu, C.3    Gu, M.4    Li, C.5    Kong, W.6
  • 18
    • 68349150756 scopus 로고    scopus 로고
    • CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
    • Nishimura S, Manabe I, Nagasaki M, Eto K, Yamashita H, Ohsugi M et al. CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med 2009;15:914-920.
    • (2009) Nat Med , vol.15 , pp. 914-920
    • Nishimura, S.1    Manabe, I.2    Nagasaki, M.3    Eto, K.4    Yamashita, H.5    Ohsugi, M.6
  • 19
    • 77953006982 scopus 로고    scopus 로고
    • Genetic polymorphism of methylenetetrahydrofolate reductase G1793A, hyperhomocysteinemia, and folate deficiency correlate with ulcerative colitis in central China
    • Jiang Y, Zhao J, Jiang T, Ge L, Zhou F, Chen Z et al. Genetic polymorphism of methylenetetrahydrofolate reductase G1793A, hyperhomocysteinemia, and folate deficiency correlate with ulcerative colitis in central China. J Gastroenterol Hepatol 2010;25:1157-1161.
    • (2010) J Gastroenterol Hepatol , vol.25 , pp. 1157-1161
    • Jiang, Y.1    Zhao, J.2    Jiang, T.3    Ge, L.4    Zhou, F.5    Chen, Z.6
  • 21
    • 0029849012 scopus 로고    scopus 로고
    • Prevention and amelioration of collagen-induced arthritis by blockade of the CD28 co-stimulatory pathway: Requirement for both B7-1 and B7-2
    • Webb LM, Walmsley MJ, Feldmann M. Prevention and amelioration of collagen-induced arthritis by blockade of the CD28 co-stimulatory pathway: requirement for both B7-1 and B7-2. Eur J Immunol 1996;26:2320-2328.
    • (1996) Eur J Immunol , vol.26 , pp. 2320-2328
    • Webb, L.M.1    Walmsley, M.J.2    Feldmann, M.3
  • 22
    • 0035803552 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte antigen 4 and CD28 modulate cell surface raft expression in their regulation of T cell function
    • Martin M, Schneider H, Azouz A, Rudd CE. Cytotoxic T lymphocyte antigen 4 and CD28 modulate cell surface raft expression in their regulation of T cell function. J Exp Med 2001;194:1675-1681.
    • (2001) J Exp Med , vol.194 , pp. 1675-1681
    • Martin, M.1    Schneider, H.2    Azouz, A.3    Rudd, C.E.4
  • 24
    • 0037648405 scopus 로고    scopus 로고
    • Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease
    • Ueda H, Howson JM, Esposito L, Heward J, Snook H, Chamberlain G et al. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 2003;423:506-511.
    • (2003) Nature , vol.423 , pp. 506-511
    • Ueda, H.1    Howson, J.M.2    Esposito, L.3    Heward, J.4    Snook, H.5    Chamberlain, G.6
  • 25
    • 37449033708 scopus 로고    scopus 로고
    • TCR/CD3 mediated stop-signal is decoupled in T-cells from Ctla4 deficient mice
    • Downey J, Smith A, Schneider H, Hogg N, Rudd CE. TCR/CD3 mediated stop-signal is decoupled in T-cells from Ctla4 deficient mice. Immunol Lett 2008;115:70-72.
    • (2008) Immunol Lett , vol.115 , pp. 70-72
    • Downey, J.1    Smith, A.2    Schneider, H.3    Hogg, N.4    Rudd, C.E.5
  • 27
    • 0033840979 scopus 로고    scopus 로고
    • EEA1, a tethering protein of the early sorting endosome, shows a polarized distribution in hippocampal neurons, epithelial cells, and fibroblasts
    • Wilson JM, de Hoop M, Zorzi N, Toh BH, Dotti CG, Parton RG. EEA1, a tethering protein of the early sorting endosome, shows a polarized distribution in hippocampal neurons, epithelial cells, and fibroblasts. Mol Biol Cell 2000;11:2657-2671.
    • (2000) Mol Biol Cell , vol.11 , pp. 2657-2671
    • Wilson, J.M.1    De Hoop, M.2    Zorzi, N.3    Toh, B.H.4    Dotti, C.G.5    Parton, R.G.6
  • 28
    • 33749041268 scopus 로고    scopus 로고
    • Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy
    • Eskelinen EL. Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy. Mol Aspects Med 2006;27:495-502.
    • (2006) Mol Aspects Med , vol.27 , pp. 495-502
    • Eskelinen, E.L.1
  • 29
    • 0035221568 scopus 로고    scopus 로고
    • Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not TH2 cytokines
    • Kane LP, Andres PG, Howland KC, Abbas AK, Weiss A. Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not TH2 cytokines. Nat Immunol 2001;2:37-44.
    • (2001) Nat Immunol , vol.2 , pp. 37-44
    • Kane, L.P.1    Andres, P.G.2    Howland, K.C.3    Abbas, A.K.4    Weiss, A.5
  • 31
    • 2142817119 scopus 로고    scopus 로고
    • B7-1/B7-2 costimulation regulates plaque antigen-specific T-cell responses and atherogenesis in lowdensity lipoprotein receptor-deficient mice
    • Buono C, Pang H, Uchida Y, Libby P, Sharpe AH, Lichtman AH. B7-1/B7-2 costimulation regulates plaque antigen-specific T-cell responses and atherogenesis in lowdensity lipoprotein receptor-deficient mice. Circulation 2004;109:2009-2015.
    • (2004) Circulation , vol.109 , pp. 2009-2015
    • Buono, C.1    Pang, H.2    Uchida, Y.3    Libby, P.4    Sharpe, A.H.5    Lichtman, A.H.6
  • 32
    • 2342562582 scopus 로고    scopus 로고
    • Evidence for the involvement of T cell costimulation through the B-7/CD28 pathway in atherosclerotic plaques from apolipoprotein e knockout mice
    • Afek A, Harats D, Roth A, Keren G, George J. Evidence for the involvement of T cell costimulation through the B-7/CD28 pathway in atherosclerotic plaques from apolipoprotein E knockout mice. Exp Mol Pathol 2004;76:219-223.
    • (2004) Exp Mol Pathol , vol.76 , pp. 219-223
    • Afek, A.1    Harats, D.2    Roth, A.3    Keren, G.4    George, J.5
  • 33
    • 0029120245 scopus 로고
    • CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation
    • Krummel MF, Allison JP. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J Exp Med 1995;182:459-465.
    • (1995) J Exp Med , vol.182 , pp. 459-465
    • Krummel, M.F.1    Allison, J.P.2
  • 34
    • 0037025948 scopus 로고    scopus 로고
    • CD28-dependent activation of protein kinase B/Akt blocks Fas-mediated apoptosis by preventing death-inducing signaling complex assembly
    • Jones RG, Elford AR, Parsons MJ, Wu L, Krawczyk CM, Yeh WC et al. CD28-dependent activation of protein kinase B/Akt blocks Fas-mediated apoptosis by preventing death-inducing signaling complex assembly. J Exp Med 2002;196: 335-348.
    • (2002) J Exp Med , vol.196 , pp. 335-348
    • Jones, R.G.1    Elford, A.R.2    Parsons, M.J.3    Wu, L.4    Krawczyk, C.M.5    Yeh, W.C.6
  • 35
    • 0029144281 scopus 로고
    • The critical role of CD28 signalling in the prevention of human T-cell anergy
    • Boussiotis VA, Freeman GJ, Gribben JG, Nadler LM. The critical role of CD28 signalling in the prevention of human T-cell anergy. Res Immunol 1995;146:140-149.
    • (1995) Res Immunol , vol.146 , pp. 140-149
    • Boussiotis, V.A.1    Freeman, G.J.2    Gribben, J.G.3    Nadler, L.M.4
  • 36
    • 0034823168 scopus 로고    scopus 로고
    • Signaling through CD28 and CTLA-4 controls two distinct forms of T cell anergy
    • Wells AD, Walsh MC, Bluestone JA, Turka LA. Signaling through CD28 and CTLA-4 controls two distinct forms of T cell anergy. J Clin Invest 2001;108:895-903.
    • (2001) J Clin Invest , vol.108 , pp. 895-903
    • Wells, A.D.1    Walsh, M.C.2    Bluestone, J.A.3    Turka, L.A.4
  • 38
    • 82255192901 scopus 로고    scopus 로고
    • The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses
    • Walker LS, Sansom DM. The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses. Nat Rev Immunol 2011;11:852-863.
    • (2011) Nat Rev Immunol , vol.11 , pp. 852-863
    • Walker, L.S.1    Sansom, D.M.2
  • 39
    • 0033587676 scopus 로고    scopus 로고
    • Defective CTLA-4 cycling pathway in Chediak-Higashi syndrome: A possible mechanism for deregulation of T lymphocyte activation
    • Barrat FJ, Le Deist F, Benkerrou M, Bousso P, Feldmann J, Fischer A et al. Defective CTLA-4 cycling pathway in Chediak-Higashi syndrome: a possible mechanism for deregulation of T lymphocyte activation. Proc Natl Acad Sci USA 1999;96:8645-8650.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 8645-8650
    • Barrat, F.J.1    Le Deist, F.2    Benkerrou, M.3    Bousso, P.4    Feldmann, J.5    Fischer, A.6
  • 41
    • 0033567050 scopus 로고    scopus 로고
    • Kirchhausen Tet al.Cytolytic T lymphocyte-associated antigen-4 and the TCR zeta/CD3 complex, but not CD28, interact with clathrin adaptor complexes AP-1 and AP-2
    • SchneiderH,MartinM,Agarraberes FA, Yin L, Rapoport I, Kirchhausen Tet al.Cytolytic T lymphocyte-associated antigen-4 and the TCR zeta/CD3 complex, but not CD28, interact with clathrin adaptor complexes AP-1 and AP-2. J Immunol 1999;163:1868-1879.
    • (1999) J Immunol , vol.163 , pp. 1868-1879
    • Schneider, H.1    Martin, M.2    Agarraberes, F.A.3    Yin, L.4    Rapoport, I.5
  • 43
    • 0033552883 scopus 로고    scopus 로고
    • Atherosclerosis: An inflammatory disease
    • Ross R. Atherosclerosis: an inflammatory disease. N Engl J Med 1999;340:115-126.
    • (1999) N Engl J Med , vol.340 , pp. 115-126
    • Ross, R.1
  • 44
    • 0036839228 scopus 로고    scopus 로고
    • Inflammation and immune responses in atherosclerosis
    • Greaves DR, Channon KM. Inflammation and immune responses in atherosclerosis. Trends Immunol 2002;23:535-541.
    • (2002) Trends Immunol , vol.23 , pp. 535-541
    • Greaves, D.R.1    Channon, K.M.2
  • 45
    • 61449121033 scopus 로고    scopus 로고
    • A novel treatment option in rheumatoid arthritis: Abatacept, a selective modulator of T-cell co-stimulation
    • Dejaco C, Duftner C, Wipfler E, Schirmer M. A novel treatment option in rheumatoid arthritis: abatacept, a selective modulator of T-cell co-stimulation. Wien Med Wochenschr 2009;159:70-75.
    • (2009) Wien Med Wochenschr , vol.159 , pp. 70-75
    • Dejaco, C.1    Duftner, C.2    Wipfler, E.3    Schirmer, M.4


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