Opinion: The GITR-GITRL interaction: Co-stimulation or contrasuppression of regulatory activity?

Nature Reviews Immunology

Volumn 6, Issue 8, 2006, Pages 613-618

  Shevach, Ethan M ^a   Stephens, Geoffrey L ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOCORTICOID INDUCED TUMOUR NECROSIS FACTOR RECEPTOR LIGAND; GLUCOCORTICOID INDUCED TUMOUR NECROSIS FACTOR RECEPTOR RELATED PROTEIN; PROTEIN; UNCLASSIFIED DRUG; NERVE GROWTH FACTOR RECEPTOR; TNFRSF18 PROTEIN, HUMAN; TNFRSF18 PROTEIN, MOUSE; TNFSF18 PROTEIN, HUMAN; TNFSF18 PROTEIN, MOUSE; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR;

CD4+ CD25+ T LYMPHOCYTE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE FUNCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REVIEW; T LYMPHOCYTE; ANIMAL; ARTICLE; AUTOIMMUNE DISEASE; BIOLOGICAL MODEL; CYTOLOGY; HUMAN; IMMUNOLOGY; METABOLISM; MOUSE; NEOPLASM; PROTEIN BINDING; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; AUTOIMMUNE DISEASES; HUMANS; LYMPHOCYTE ACTIVATION; MICE; MODELS, IMMUNOLOGICAL; NEOPLASMS; PROTEIN BINDING; RECEPTORS, NERVE GROWTH FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR; T-LYMPHOCYTE SUBSETS; TUMOR NECROSIS FACTORS;

EID: 33746575650     PISSN: 14741733     EISSN: None     Source Type: Journal    
DOI: 10.1038/nri1867     Document Type: Review

References (34)

1. + immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 16, 311-323 (2002).
2. + regulatory T cells through GITR breaks immunological self-tolerance. Nature Immunol. 3, 135-142 (2002).
3. Gershon, R. K. et al. Contrasuppression. A novel immunoregulatory activity. J. Exp. Med. 153, 1533-1546 (1981).
4. Nocentini, G. et al. A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. Proc. Natl Acad. Sci. USA 94, 6216-6221 (1997).
5. Gurney, A. L. et al. Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR. Curr. Biol. 9, 215-218 (1999).
6. Kwon, B. et al. Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand. J. Biol. Chem. 274, 6056-6061 (1999).
7. Zhan, Y. et al. TCR-mediated activation promotes GITR upregulation in T cells and resistance to glucocorticoid-induced death. Int. Immunol. 16, 1315-1321 (2004).
8. Ronchetti, S. et al. GITR, a member of the TNF receptor superfamily, is costimulatory to mouse T lymphocyte subpopulations. Eur. J. Immunol. 34, 613-622 (2004).
9. + T cell activation and experimental autoimmune encephalomyelitis. J. Immunol. 172, 4686-4690 (2004).
10. + T cells. J. Immunol. 172, 7306-7314 (2004).
11. + T cells. J. Immunol. 173, 5008-5020 (2004).
12. Kim, B. J. et al. Constitutive and cytokine-induced GITR ligand expression on human retinal pigment epithelium and photo receptors. Invest. Ophthalmol. Vis. Sci. 45, 3170-3176 (2004).
13. Kim, J. D. et al. Cloning and characterization of GITR ligand. Genes Immun. 4, 564-569 (2003).
14. Tone, M. et al. Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells. Proc. Natl Acad. Sci. USA 100, 15059-15064 (2003).
15. Ji, H. B. et al. Cutting edge: the natural ligand for glucocorticoid-induced TNF receptor-related protein abrogates regulatory T cell suppression. J. Immunol. 172, 5823-5827 (2004).
16. Croft, M. Co-stimulatory members of the TNFR family: keys to effective T-cell immunity? Nature Rev. Immunol. 3, 609-620 (2003).
17. Suvas, S. et al. In vivo kinetics of GITR and GITR ligand expression and their functional significance in regulating viral immunopathology. J. Virol. 79, 11935-11942 (2005).
18. Esparza, E. M. & Arch, R. H. Glucocorticoid-induced TNF receptor, a costimulatory receptor on naive and activated T cells, uses TNF receptor-associated factor 2 in a novel fashion as an inhibitor of NF-κ B activation. J. Immunol. 174, 7875-7882 (2005).
19. Esparza, E. M. & Arch, R. H. Glucocorticoid-induced TNF receptor functions as a costimulatory receptor that promotes survival in early phases of T cell activation. J. Immunol. 174, 7869-7874 (2005).
20. Watts, T. H. TNF/TNFR family members in costimulation of T cell responses. Annu. Rev. Immunol. 23, 23-68 (2005).
21. Esparza, E. M. & Arch, R. H. Signaling triggered by glucocorticoid-induced tumor necrosis factor receptor family-related gene: regulation at the interface between regulatory T cells and immune effector cells. Front. Biosci. 11, 1448-1465 (2006).
22. Nocentini, G. & Riccardi, C. GITR: a multifaceted regulator of immunity belonging to the tumor necrosis factor receptor superfamily. Eur. J. Immunol. 35, 1016-1022 (2005).
23. + T cells in graft-versus-host disease. J. Exp. Med. 200, 149-157 (2004).
24. + T cells by regulatory T cells during persistent retroviral infection. Immunity 20, 293-303 (2004).
25. + regulatory T cells. J. Exp. Med. 202, 885-891 (2005).
26. He, H. et al. Reduction of retrovirus-induced immunosuppression by in vivo modulation of T cells during acute infection. J. Virol. 78, 11641-11647 (2004).
27. + T regulatory cells. J. Immunol. 176, 3301-3305 (2006).
28. Patel, M. et al. Glucocorticoid-induced TNFR family-related protein (GITR) activation exacerbates murine asthma and collagen-induced arthritis. Eur. J. Immunol. 35, 3581-3590 (2005).
29. Turk, M. J. et al. Concomitant tumor immunity to a poorly immunogenic melanoma is prevented by regulatory T cells. J. Exp. Med. 200, 771-782 (2004).
30. Calmels, B. et al. Bypassing tumor-associated immune suppression with recombinant adenovirus constructs expressing membrane bound or secreted GITRL. Cancer Gene Ther. 12, 198-205 (2005).
31. Taylor, M. D. et al. Removal of regulatory T cell activity reverses hyporesponsiveness and leads to filarial parasite clearance in vivo. J. Immunol. 174, 4924-4933 (2005).
32. La, S., Kim, E. & Kwon, B. In vivo ligation of glucocorticoid-induced TNF receptor enhances the T-cell immunity to herpes simplex virus type 1. Exp. Mol. Med. 37, 193-198 (2005).
33. Cuzzocrea, S. et al. Role of glucocorticoid-induced TNF receptor family gene (GITR) in collagen-induced arthritis. FASEB J. 19, 1253-1265 (2005).
34. Agostini, M. et al. The glucocorticoid-induced tumor necrosis factor receptor-related gene modulates the response to Candida albicans infection. Infect. Immun. 73, 7502-7508 (2005).