Thymic CD4 T cell selection requires attenuation of March8-mediated MHC II turnover in cortical epithelial cells through CD83

Journal of Experimental Medicine

Volumn 213, Issue 9, 2016, Pages 1685-1694

  von Rohrscheidt, Julia ^a   Petrozziello, Elisabetta ^a   Nedjic, Jelena ^a,e   Federle, Christine ^a   Krzyzak, Lena ^b   Ploegh, Hidde L ^c   Ishido, Satoshi ^d   Steinkasserer, Alexander ^b   Klein, Ludger ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^c WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^d HYOGO COLLEGE OF MEDICINE   (Japan)

^e BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BREFELDIN A; C REACTIVE PROTEIN; CD83 ANTIGEN; LENTIVIRUS VECTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MARCH1 ENZYME; MARCH8 ENZYME; UBIQUITIN PROTEIN LIGASE; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; HLA ANTIGEN CLASS 2; IMMUNOGLOBULIN; LEUKOCYTE ANTIGEN; MARCH8 PROTEIN, MOUSE; MEMBRANE PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ARTICLE; BRAIN CELL; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL MATURATION; CELL SELECTION; DENDRITIC CELL; ENZYME SPECIFICITY; EPITHELIUM CELL; GENE EXPRESSION; HEMATOPOIETIC CELL; KIDNEY CAPSULE; LIMIT OF DETECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; SIGNAL TRANSDUCTION; THYMOCYTE; THYMUS; TURNOVER TIME; UBIQUITINATION; UPREGULATION; ANIMAL; C57BL MOUSE; IMMUNOLOGY; METABOLISM; PHYSIOLOGY;

ANIMALS; ANTIGENS, CD; CD4-POSITIVE T-LYMPHOCYTES; DENDRITIC CELLS; EPITHELIAL CELLS; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNOGLOBULINS; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; THYMUS GLAND; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84984856739     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20160316     Document Type: Article

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