Interleukin-4 deficiency decreases atherosclerotic lesion formation in a site-specific manner in female LDL receptor-/- mice

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 22, Issue 3, 2002, Pages 456-461

  King, Victoria L ^a   Szilvassy, Stephen J ^a   Daugherty, Alan ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Atherosclerosis; Bone marrow transplant; Interleukin 4; Low density lipoprotein receptors; T lymphocytes

Indexed keywords

CHOLESTEROL; CHOLIC ACID; CYTOKINE; INTERLEUKIN 4; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA; SATURATED FATTY ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA ARCH; AORTA ROOT; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CELL ACTIVATION; CHOLESTEROL BLOOD LEVEL; CYTOKINE RELEASE; FEMALE; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; IRRADIATION; LIPID DIET; LYMPHOCYTE; MAST CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL;

ANIMALS; AORTA; AORTA, THORACIC; AORTIC DISEASES; ARTERIOSCLEROSIS; BONE MARROW TRANSPLANTATION; CHOLESTEROL; FEMALE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; INTERLEUKIN-4; LIPOPROTEINS; MICE; MICE, KNOCKOUT; RECEPTORS, LDL; TRIGLYCERIDES;

EID: 0036124714     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/hq0302.104905     Document Type: Article

References (48)

1. Lymphocytes in atherogenesis
2. Regional accumulations of T cells, macrophages, and smooth muscle cells in the human atherosclerotic plaque
3. Increased expression of heat shock protein-65 coincides with a population of infiltrating T-lymphocytes in atherosclerotic lesions of rabbits specifically responding to heat shock protein-65
4. Inflammatory and immunological nature of atherosclerosis
5. Detection of activated T lymphocytes in the human atherosclerotic plaque
6. Adhesion of activated T lymphocytes to vascular smooth muscle cells and dermal fibroblasts is mediated by beta1- and beta2-integrins
7. The growth of human atherosclerosis: Cell proliferation and collagen synthesis
8. Immunohistochemical and ultra-structural demonstration of the lymphocyte-macrophage interaction in human aortic intima
9. Specialized membrane contacts between immunocompetent cells in human atherosclerotic plaques
10. Lymphocyte populations in atherosclerotic lesions of apoE -/- and LDL receptor -/- mice: Decreasing density with disease progression
11. Evidence for a local immune response in atherosclerosis: CD4(+) T cells infiltrate lesions of apolipoprotein-E-deficient mice
12. IFN-γ potentiates atherosclerosis in apoE knock-out mice
13. Two types of murine helper T cell clone. I: Definition according to profiles of lymphokine activities and secreted proteins
14. Hypercholesterolemia is associated with a T helper (Th) 1/Th2 switch of the autoimmune response in atherosclerotic apo E-knockout mice
15. Exogenous interferon-γ enhances atherosclerosis in apolipoprotein E-/- mice
16. Interleukin-4 and IFN-γ differentially stimulate macrophage chemoat-tractant protein-1 (MCP-1) and eotaxin production by intestinal epithelial cells
17. TNF-α and IL-4 synergistically increase vascular cell adhesion molecule-1 expression in cultured vascular smooth muscle cells
18. Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenase
19. Disruption of 12/15-lipoxygenase expression in peritoneal macrophages: Enhanced utilization of the 5-lipoxygenase pathway and diminished oxidation of low density lipoprotein
20. Interleukin-4 augments acetylated LDL induced cholesterol esterification in macrophages
21. Regulation of monocyte CD36 and thrombospondin-1 expression by soluble mediators
22. IL-4 secretion by CD4+ NKI+ T cells induces monocyte chemoattractant protein-1 in early listeriosis
23. 2-macroglobulin receptors in macrophages of atherosclerotic lesions from cholesterol-fed New Zealand and heterozygous Watanabe heritable hyperlipidemic rabbits
24. The effects of total lymphocyte deficiency on the extent of atherosclerosis in apolipoprotein E-/-mice
25. Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice
26. Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation
27. Treatment of severe hypercholesterolemia in apolipoprotein E-deficient mice by bone marrow transplantation
28. Participation of innate and acquired immunity in atherosclerosis
29. Mast cells in rupture-prone areas of human coronary atheromas produce and store TNF-alpha
30. Mast cells of two types differing in neutral protease composition in the human aortic intima: Demonstration of tryptase- and tryptase/chymase-containing mast cells in normal intimas, fatty streaks and the shoulder region of atheromas
31. A direct role for the macrophage low density lipoprotein receptor in atherosclerotic lesion formation
32. Role of leukocyte-specific LDL receptors on plasma lipoprotein cholesterol and atherosclerosis in mice
33. Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E-deficient mice
34. Regression of atherosclerosis induced by liver-directed gene transfer of apolipoprotein A-I in mice
35. Site-specific antiatherogenic effect of probucol in apolipoprotein E-deficient mice
36. Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in low density lipoprotein receptor-deficient mice
37. Susceptibility to atherosclerosis in mice expressing exclusively apolipoprotein B48 or apolipoprotein B100
38. Effect of immune deficiency on lipoproteins and atherosclerosis in male apolipoprotein E-deficient mice
39. Requisite role for interleukin-4 in the acceleration of fatty streaks induced by heat shock protein 65 or Mycobacterium tuberculosis
40. Cross-regulatory roles of interleukin (IL)-12 and IL-10 in atherosclerosis
41. Protective role of interleukin-10 in atherosclerosis
42. Interleukin-10 blocks atherosclerotic events in vitro and in vivo
43. Macrophage deactivation by interleukin 10
44. IL-10 inhibits cytokine production by activated macrophages
45. ATH-1 a gene determining atherosclerosis susceptibility and high density lipoprotein levels in mice
46. Class A scavenger receptors: Recent advances in elucidation of structure-function relationships and their role in atherosclerosis
47. IL-4-induced oxidative stress upregulates VCAM-1 gene expression in human endothelial cells
48. Interleukin-13 alters the activation state of murine macrophages in vitro: Comparison with interleukin-4 and interferon-gamma