Mitochondrial anomalies: Driver to age associated degenerative human ailments

Frontiers in Bioscience - Landmark

Volumn 21, Issue 4, 2016, Pages 769-793

  Bunkar, Neha ^a   Bhargava, Arpit ^a,b   Khare, Naveen Kumar ^b   Mishra, Pradyumna Kumar ^a,b  

^a DR H S GOUR UNIVERSITY   (India)

^b TATA MEMORIAL HOSPITAL   (India)

Author keywords

Mitochondria Targeting; Mitochondrial Dysfunction; Oxidative Damage; Oxidative Stress; Redox Signaling; Review

Indexed keywords

AGING; DISORDERS OF MITOCHONDRIAL FUNCTIONS; GENETIC EPIGENESIS; GENETICS; HUMAN; MITOPHAGY; OXIDATION REDUCTION REACTION; PATHOLOGY; SIGNAL TRANSDUCTION;

AGING; EPIGENESIS, GENETIC; HUMANS; MITOCHONDRIAL DEGRADATION; MITOCHONDRIAL DISEASES; OXIDATION-REDUCTION; SIGNAL TRANSDUCTION;

EID: 85016107254     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/4420     Document Type: Review

References (170)

1. N. S. Chandel: Mitochondria as signaling organelles. BMC Biol 12, 34 (2014) DOI: 10.1186/1741-7007-12-34
2. V. G. Antico Arciuch, M. E. Elguero, J. J. Poderoso, M. C. Carreras: Mitochondrial regulation of cell cycle and proliferation. Antioxid Redox Signal 16(10), 1150-1180 (2012) DOI: 10.1089/ars.2011.4085
3. S. P. Kabekkodu, S. Chakrabarty, V. Shukla, V. K. Varghese, K. K. Singh, K. Thangaraj, K. Satyamoorthy: Mitochondrial biology: from molecules to disease symposium. Mitochondrion S1567-7249(15)30015-5 (2015) DOI: 10.1.016/j.mito.2015.0.7.0.08 (2015)
4. D. E. Handy, J. Loscalzo: Redox regulation of mitochondrial function. Antioxid Redox Signal 16(11), 1323-1367 (2012) DOI: 10.1089/ars.2011.4123
5. A. H. Schapira: Mitochondrial diseases. Lancet 379(9828), 1825-1834 (2012) DOI: 10.1016/S0140-6736(11)61305-6
6. S. S. Hardas, R. Sultana, A. M. Clark, T. L. Beckett, L. I. Szweda, M. P. Murphy, D. A. Butterfield: Oxidative modification of lipoic acid by HNE in Alzheimer disease brain. Redox Biol 1, 80-85 (2013) DOI: 10.1016/j.redox.2013.01.002
7. V. Dias, E. Junn, M. M. Mouradian: The role of oxidative stress in Parkinson's disease. J Parkinsons Dis 3(4), 461-491 (2013)
8. M. A. Kluge, J. L. Fetterman, J. A. Vita: Mitochondria and endothelial function. Circ Res 112(8), 1171-1188 (2013) DOI: 10.1161/CIRCRESAHA.111.300233
9. Z. A. Ma, Z. Zhao, J. Turk: Mitochondrial Dysfunction and beta-Cell Failure in Type 2 Diabetes Mellitus. Exp Diabetes Res 2012, 703538 (2012) DOI: 10.1155/2012/703538
10. D. V. Ziegler, C. D. Wiley, M. C. Velarde: Mitochondrial effectors of cellular senescence: beyond the free radical theory of aging. Aging Cell 14(1), 1-7 (2015) DOI: 10.1111/acel.12287
11. H. C. Lee, K. H. Huang, T. S. Yeh, C. W. Chi: Somatic alterations in mitochondrial DNA and mitochondrial dysfunction in gastric cancer progression. World J Gastroenterol 20(14), 3950-3959 (2014) DOI: 10.3748/wjg.v20.i14.3950
12. D. C. Wallace: A mitochondrial bioenergetic etiology of disease. J Clin Invest 123(4), 1405-1412 (2013) DOI: 10.1172/JCI61398
13. L. Milane, M. Trivedi, A. Singh, M. Talekar, M. Amiji: Mitochondrial biology, targets, and drug delivery. J Control Release 207, 40-58 (2015) DOI: 10.1016/j.jconrel.2015.03.036
14. A. K. Biala, R. Dhingra, L. A. Kirshenbaum: Mitochondrial dynamics: orchestrating thejourney to advanced age. J Mol Cell Cardiol 83, 37-43 (2015) DOI: 10.1016/j.yjmcc.2015.04.015
15. R. K. Lane, T. Hilsabeck, S. L. Rea: The role of mitochondrial dysfunction in age-related diseases. Biochim Biophys Acta. DOI: 10.1.016/j.bbabio.2015.0.5.0.21 (2015)
16. M. Wilding: Potential long-term risks associated with maternal aging (the role of the mitochondria). Fertil Steril 103(6), 1397-1401 (2015) DOI: 10.1016/j.fertnstert.2015.03.034
17. D. T. Shaughnessy, K. McAllister, L. Worth, A. C. Haugen, J. N. Meyer, F. E. Domann, B. Van Houten, R. Mostoslavsky, S. J. Bultman, A. A. Baccarelli, T. J. Begley, R. W. Sobol, M. D. Hirschey, T. Ideker, J. H. Santos, W. C. Copeland, R. R. Tice, D. M. Balshaw, F. L. Tyson: Mitochondria, energetics, epigenetics, and cellular responses to stress. Environ Health Perspect 122(12), 1271-1278 (2014) DOI: 10.1289/ehp.1408418
18. R. L. Maher, A. Prasad, O. Rizvanova, S. S. Wallace, D. S. Pederson: Contribution of DNA unwrapping from histone octamers to the repair of oxidatively damaged DNA in nucleosomes. DNA Repair 12, 964-971 (2013) DOI: 10.1016/j.dnarep.2013.08.010
19. P. F. Chinnery, H. R. Elliott, G. Hudson, D. C. Samuels C. L. Relton: Epigenetics, epidemiology and mitochondrial DNA diseases. Int J Epidemiol 41, 177-187 (2012) DOI: 10.1093/ije/dyr232
20. A. Salminen, K. Kaarniranta, M. Hiltunena, A. Kauppinen: Krebs cycle dysfunction shapes epigenetic landscape of chromatin: Novel insights into mitochondrial regulation of aging process. Cellular Signal 26, 1598-1603 (2014) DOI: 10.1016/j.cellsig.2014.03.030
21. D. J. Smiraglia, M. Kulawiec, G. L. Bistulfi, S. G. Gupta, K. K. Singh: A novel role for mitochondria in regulating epigenetic modification in the nucleus. Cancer Biol Ther 7(8), 1182-1190 (2008) DOI: 10.4161/cbt.7.8.6215
22. P. K. Mishra, N. Bunkar, G. V. Raghuram, N. K. Khare, N. Pathak, A. Bhargava: Epigenetic dimension of oxygen radical injury in spermatogonial epithelial cells. Reprod Toxicol 52, 40-56 (2015) DOI: 10.1016/j.reprotox.2015.02.006
23. G. V. Raghuram, P. K. Mishra: Stress induced premature senescence: A new culprit in ovarian tumorigenesis? Indian J Med Res 140, 120-129 (2014) (doi not found)
24. P. K. Mishra, G. V. Raghuram, D. Jain, S. K. Jain, N. K. Khare, N. Pathak: Mitochondrial oxidative stress-induced epigenetic modifications in pancreatic epithelial cells. Int J Toxicol 33(2), 116-129 (2014) DOI: 10.1177/1091581814524064
25. D. Bellizzi, P. D'Aquila, T. Scafone, M. Giordano, V. Riso, A. Riccio, G. Passarino: The control region of mitochondrial DNA shows an unusual CpG and non-CpG methylation pattern. DNA Res 20(6), 537-547 (2013) DOI: 10.1093/dnares/dst029
26. L. S. Shock, P. V. Thakkar, E. J. Peterson, R. G. Moran, S. M. Taylor: DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria. Proc Natl Acad Sci U S A 108(9), 3630-3635 (2011) DOI: 10.1073/pnas.1012311108
27. Z. Chen, Y. Li, H. Zhang, P. Huang, R. Luthra: Hypoxia-regulated microRNA-210 modulates mitochondrial function and decreases ISCU and COX10 expression. Oncogene 29(30), 4362-4368 (2010) DOI: 10.1038/onc.2010.193
28. B. T. Kren, P. Y. Wong, A. Sarver, X. Zhang, Y. Zeng, C. J. Steer: MicroRNAs identified in highly purified liver-derived mitochondria may play a role in apoptosis. RNA Biol 6(1), 65-72 (2009) DOI: 10.4161/rna.6.1.7534
29. F. Sato, S. Tsuchiya, S. J. Meltzer, K. Shimizu: MicroRNAs and epigenetics. FEBS J 278(10), 1598-609 (2011) DOI: 10.1111/j.1742-4658.2011.08089.x
30. B. Westermann: Mitochondrial fusion and fission in cell life and death. Nat Rev Mol Cell Biol 11(12), 872-884 (2010) DOI: 10.1038/nrm3013
31. J. W. Rensvold, S. E. Ong, A. Jeevananthan, S. A. Carr, V. K. Mootha, D. J. Pagliarini: Complementary RNA and protein profiling identifies iron as a key regulator ofmitochondrial biogenesis. Cell Rep 3(1), 237-245 (2013) DOI: 10.1016/j.celrep.2012.11.029
32. A. Y. Seo, A. M. Joseph, D. Dutta, J. C. Hwang, J. P. Aris, C. Leeuwenburgh: New insights into the role of mitochondria in aging: mitochondrial dynamics and more. J Cell Sci 123(15), 2533-2542 (2010) DOI: 10.1242/jcs.070490
33. V. Eisner, G. Lenaers, G. Hajnóczky: Mitochondrial fusion is frequent in skeletal muscle and supports excitation-contraction coupling. J Cell Biol 205(2), 179-195 (2014) DOI: 10.1083/jcb.201312066
34. R. C. Scarpulla: Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network. Biochim Biophys Acta 1813(7), 1269-1278 (2011) DOI: 10.1016/j.bbamcr.2010.09.019
35. S. B. Wu, Y. T. Wu, T. P. Wu, Y. H. Wei: Role of AMPK-mediated adaptive responses in human cells with mitochondrial dysfunction to oxidative stress. Biochim Biophys Acta 1840(4), 1331-1344 (2014) DOI: 10.1016/j.bbagen.2013.10.034
36. M. Redmann, M. Dodson, M. Boyer-Guittaut, V. Darley-Usmar, J. Zhang: Mitophagy mechanisms and role in human diseases. Int J Biochem Cell Biol 53, 127-133 (2014) DOI: 10.1016/j.biocel.2014.05.010
37. J. J. Lemasters: Variants of mitochondrial autophagy: Types 1 and 2 mitophagy and micromitophagy (Type 3). Redox Biol 2, 749-754(2014) DOI: 10.1016/j.redox.2014.06.004
38. A. H. Chourasia, M. L. Boland, K. F. Macleod: Mitophagy and cancer. Cancer Metab 3, 4 (2015) DOI: 10.1186/s40170-015-0130-8
39. W. Springer, P. J. Kahle: Regulation of PINK1-Parkin-mediated mitophagy. Autophagy 7(3), 266-278 (2011) DOI: 10.4161/auto.7.3.14348
40. M. Boyer-Guittaut, L. Poillet, Q. Liang, E. Bôle-Richard, X. Ouyang, G. A. Benavides, F. Z. Chakrama, A. Fraichard, V. M. Darley-Usmar, G. Despouy, M. Jouvenot, R. Delage-Mourroux, J. Zhang: The role of GABARAPL1/GEC1 in autophagic flux and mitochondrial quality control in MDA-MB-436 breast cancer cells. Autophagy 10(6), 986-1003 (2014) DOI: 10.4161/auto.28390
41. G. W. Dorn: Mitochondrial pruning by Nix and BNip3: an essential function for cardiacexpressed death factors. J Cardiovasc Transl Res 3, 374-383 (2010) DOI: 10.1007/s12265-010-9174-x
42. D. C. Wallace, W. Fan: Energetics, epigenetics, mitochondrial genetics. Mitochondrion 10(1), 12-31 (2010) DOI: 10.1016/j.mito.2009.09.006
43. S. Kröller-Schön, S. Steven, S. Kossmann, A. Scholz, S. Daub, M. Oelze, N. Xia, M. Hausding, Y. Mikhed, E. Zinssius, M. Mader, P. Stamm, N. Treiber, K. Scharffetter-Kochanek, H. Li, E. Schulz, P. Wenzel, T. Münzel, A. Daiber: Molecular mechanisms of the crosstalk between mitochondria and NADPH oxidase through reactive oxygen species-studies in white blood cells and in animal models. Antioxid Redox Signal 20(2), 247-266 (2014) DOI: 10.1089/ars.2012.4953
44. S. Zhang, C. Yang, Z. Yang, D. Zhang, X. Ma, G. Mills, Z. Liu: Homeostasis of redox status derived from glucose metabolic pathway could be the key to understanding the Warburg effect. Am J Cancer Res 5(4), 1265-1280 (2015)
45. M. Muftuoglu, M. P. Mori, N. C. de Souza-Pinto: Formation and repair of oxidative damage in the mitochondrial DNA. Mitochondrion 17, 164-181 (2014). DOI: 10.1016/j.mito.2014.03.007
46. M. Lund, M. Melbye, L. J. Diaz, M. Duno, J. Wohlfahrt, J. Vissing: Mitochondrial dysfunction and risk of cancer. Br J Cancer 112(6), 1134-1140 (2015) DOI: 10.1038/bjc.2015.66
47. H. Panwar, D. Jain, S. Khan, N. Pathak, G. V. Raghuram, A. Bhargava, S. Banerjee, P. K. Mishra: Imbalance of mitochondrial-nuclear cross talk in isocyanate mediated pulmonary endothelial cell dysfunction. Redox Biol 1, 163-171 (2013) DOI: 10.1016/j.redox.2013.01.009
48. S. Khan, G. V. Raghuram, N. Pathak, S. K. Jain, D. H. Chandra, P. K. Mishra: Impairment of mitochondrial-nuclear cross talk in neutrophils of patients with type 2 diabetes mellitus. IndianJ Clin Biochem 29(1), 38-44 (2014) DOI: 10.1007/s12291-013-0321-4
49. P. K. Mishra, G. V. Raghuram, H. Panwar, D. Jain, H. Pandey, K. K. Maudar: Mitochondrial oxidative stress elicits chromosomal instability after exposure to isocyanates in human kidney epithelial cells. Free Radic Res 43(8), 718-728 (2009) DOI: 10.1080/10715760903037699
50. M. Guha, N. G. Avadhani: Mitochondrial retrograde signaling at the crossroads of tumor bioenergetics, genetics and epigenetics. Mitochondrion 13, 577-591 (2013) DOI: 10.1016/j.mito.2013.08.007
51. C. C. Hsu, H. C. Lee, Y. H. Wei: Mitochondrial DNA alterations and mitochondrial dysfunction in the progression of hepatocellular carcinoma. World J Gastroenterol 19(47), 8880-8886 (2013) DOI: 10.3748/wjg.v19.i47.8880
52. S. DiMauro, C. M. Quinzii, M. Hirano: Mutations in coenzyme Q10 biosynthetic genes. J Clin Invest 117(3), 587-589 (2007) DOI: 10.1172/JCI31423
53. E. Sahin, S. Colla, M. Liesa, J. Moslehi, F. L. Müller, M. Guo, M. Cooper, D. Kotton, A. J. Fabian, C. Walkey, R. S. Maser, G. Tonon, F. Foerster, R. Xiong, Y. A. Wang, S. A. Shukla, M. Jaskelioff, E. S. Martin, T. P. Heffernan, A. Protopopov, E. Ivanova, J. E. Mahoney, M. Kost-Alimova, S. R. Perry, R. Bronson, R. Liao, R. Mulligan, O. S. Shirihai, L. Chin, R. A. DePinho: Telomere dysfunction induces metabolic and mitochondrial compromise. Nature 470(7334), 359-365 (2011) DOI: 10.1038/nature09787
54. S. Xiong, G. Salazar, N. Patrushev, M. Ma, F. Forouzandeh, L. Hilenski, R. W. Alexander: Peroxisome proliferator-activated receptor coactivator-1alpha is a central negative regulator of vascular senescence. Arterioscler Thromb Vasc Biol 33(5), 988-998 (2013) DOI: 10.1161/ATVBAHA.112.301019
55. A. P. Gomes, N. L. Price, A. J. Ling, J. J. Moslehi, M. K. Montgomery, L. Rajman, J. P. White, J. S. Teodoro, C. D. Wrann, B. P. Hubbard, E. M. Mercken, C. M. Palmeira, R. de Cabo, A. P. Rolo, N. Turner, E. L. Bell, D. A. Sinclair: Declining NAD(+) induces a pseudohypoxic state disrupting nuclearmitochondrial communication during aging. Cell 155(7), 1624-1638 (2013) DOI: 10.1016/j.cell.2013.11.037
56. M. P. Murphy, M. Bennett: DNA Damage Links Mitochondrial Dysfunction to Atherosclerosis and the Metabolic Syndrome. Circ Res 107(8), 1021-1031 (2010) DOI: 10.1161/CIRCRESAHA.110.218966
57. S. Khan, G. V. Raghuram, A. Bhargava, N. Pathak, D. H. Chandra, S. K. Jain, P. K. Mishra: Role and clinical significance of lymphocyte mitochondrial dysfunction in type 2 diabetes mellitus. Transl Res 158(6), 344-359 (2011) DOI: 10.1016/j.trsl.2011.08.007
58. U. Mabalirajan, B. Ghosh: Mitochondrial dysfunction in metabolic syndrome and asthma. J Allergy (Cairo) 2013, 340476 (2013) DOI: 10.1155/2013/340476
59. J. Y. Youn, K. L. Siu, H. E. Lob, H. Itani, D. G. Harrison, H. Cai: Role of vascular oxidative stress in obesity and metabolic syndrome. Diabetes 63(7), 344-355 (2014) DOI: 10.2337/db13-0719
60. S. H. Chan, K. L. Wu, A. Y. Chang, M. H. Tai, J. Y. Chan: Oxidative impairment of mitochondrial electron transport chain complexes in rostral ventrolateral medulla contributes to neurogenic hypertension. Hypertension 53(2), 217-227 (2009) DOI: 10.1161/HYPERTENSIONAHA.108.116905
61. N. R. Madamanchi, M. S. Runge: Redox signaling in cardiovascular health and disease. Free Radic Biol Med 61, 473-501 (2013) DOI: 10.1016/j.freeradbiomed.2013.04.001
62. S. Rubattu, B. Pagliaro, G. Pierelli, C. Santolamazza, S. D. Castro, S. Mennuni, M. Volpe: Pathogenesis of target organ damage in hypertension: role of mitochondrial oxidative stress. Int J Mol Sci 16(1), 823-839 (2014) DOI: 10.3390/ijms16010823
63. S. I. Dikalov, R. R. Nazarewicz: Angiotensin II-induced production of mitochondrial reactive oxygen species: potential mechanisms and relevance for cardiovascular disease. Antioxid Redox Signal 19(10), 1085-1094 (2013) DOI: 10.1089/ars.2012.4604
64. S. Kröller-Schön, T. Jansen, A. Schüler, M. Oelze, P. Wenzel, M. Hausding, J. G. Kerahrodi, M. Beisele, K. J. Lackner, A. Daiber, T. Münzel, E. Schulz: Peroxisome proliferator-activated receptor, coactivator1alpha deletion induces angiotensin II-associated vascular dysfunction by increasing mitochondrial oxidative stress and vascular inflammation. Arterioscler Thromb Vasc Biol 33(8), 1928-1935 (2013) DOI: 10.1161/ATVBAHA.113.301717
65. T. V. Fiorentino, A. Prioletta, P. Zuo, F. Folli: Hyperglycemia-induced oxidative stress and its role in diabetes mellitus related cardiovascular diseases. Curr Pharm Des 19(32), 5695-5703 (2013) DOI: 10.2174/1381612811319320005
66. B. Rodriguez-Iturbe, L. Sepassi, Y. Quiroz, Z. Ni, D. C. Wallace, N. D. Vaziri: Association of mitochondrial SOD deficiency with saltsensitive hypertension and accelerated renal senescence. J Appl Physiol (1985) 102(1), 255-260 (2007) DOI: 10.1152/japplphysiol.00513.2006
67. M. Brownlee: Biochemistry and molecular cell biology of diabetic complications. Nature 414, 813-820 (2001) DOI: 10.1038/414813a
68. A. W. Gao, C. Cantó, R. H. Houtkooper: Mitochondrial response to nutrient availability and its role in metabolic disease. EMBO Mol Med 6(5), 580-589 (2014) DOI: 10.1002/emmm.201303782
69. M. E. Patti, S. Corvera The role of mitochondria in the pathogenesis of type 2 diabetes. Endocr Rev 31(3), 364-395 (2010) DOI: 10.1210/er.2009-0027
70. T. J. Kizhakekuttu, J. Wang, K. Dharmashankar, R. Ying, D. D. Gutterman, J. A. Vita, M. E. Widlansky: Adverse alterations in mitochondrial function contribute to type 2 diabetes mellitus-related endothelial dysfunction in humans. Arterioscler Thromb Vasc Biol 32, 2531-2539 (2012) DOI: 10.1161/ATVBAHA.112.256024
71. R. Li, M. X. Guan: Human mitochondrial leucyl-tRNA synthetase corrects mitochondrial dysfunctions due to the tRNALeu(UUR) A3243G mutation, associated with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like symptoms and diabetes. Mol Cell Biol 30(9), 2147-2154 (2010) DOI: 10.1128/MCB.01614-09
72. I. A. Sobenin, M. A. Sazonova, A. Y. Postnov, J. T. Salonen, Y. V. Bobryshev, A. N. Orekhov: Association of mitochondrial genetic variation with carotid atherosclerosis. PLoS ONE 8(7), e68070 (2013) DOI: 10.1371/journal.pone.0068070
73. A. Trifunovic, A. Wredenberg, M. Falkenberg, J. N. Spelbrink, A. T. Rovio, C. E. Bruder, Y. M. Bohlooly, S. Gidlöf, A. Oldfors, R. Wibom, J. Törnell, H. T. Jacobs, N. G. Larsson: Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 429(6990), 417-423 (2004) DOI: 10.1038/nature02517
74. E. Yu, P. A. Calvert, J. R. Mercer, J. Harrison, L. Baker, N. L. Figg, S. Kumar, J. J. Wang, L. A. Hurst, D. R. Obaid, A. Logan, N. E. West, M. C. Clarke, A. Vidal-Puig, M. P. Murphy, M. R. Bennett: Mitochondrial 74. DNA damage can promote atherosclerosis independently of reactive oxygen species through effects on smooth muscle cells and monocytes and correlates with higher-risk plaques in humans. Circulation 128(7), 702-712 (2014) DOI: 10.1161/CIRCULATIONAHA.113.002271
75. M. C. Gage, N. Y. Yuldasheva, H. Viswambharan, P. Sukumar, R. M. Cubbon, S. Galloway, H. Imrie, A. Skromna, J. Smith, C. L. Jackson, M. T. Kearney, S. B. Wheatcroft: Endothelium-specific insulin resistance leads to accelerated atherosclerosis in areas with disturbed flow patterns: A role for reactive oxygen species. Atherosclerosis 230(1), 131-139 (2013) DOI: 10.1016/j.atherosclerosis.2013.06.017
76. J. R. Mercer, K. K. Cheng, N. Figg, I. Gorenne, M. Mahmoudi, J. Griffin, A. Vidal-Puig, A. Logan, M. P. Murphy, M. Bennett: DNA damage links mitochondrial dysfunction to atherosclerosis and the metabolic syndrome. Circ Res 107(8), 1021-1031 (2010) DOI: 10.1161/CIRCRESAHA.110.218966
77. G. P. Shantha, B. Wasserman, B. C. Astor, J. Coresh, F. Brancati, A. R. Sharrett, J. H. Young: Association of blood lactate with carotid atherosclerosis: The atherosclerosis risk in communities (ARIC) carotid MRI Study. Atherosclerosis 228(1), 249-255 (2013) DOI: 10.1016/j.atherosclerosis.2013.02.014
78. R. Villa-Bellosta, J. Rivera-Torres, F. G. Osorio, R. Acín-Pérez, J. A. Enriquez, C. López-Otín, V. Andrés: Defective extracellular pyrophosphate metabolism promotesvascular calcification in a mouse model of Hutchinson-Gilford progeria syndrome that is ameliorated on pyrophosphate treatment. Circulation 127(24), 2442-2451 (2013) DOI: 10.1161/CIRCULATIONAHA.112.000571
79. A. Tocchi, E. K. Quarles, N. Basisty, L. Gitari, P. S. Rabinovitch: Mitochondrial dysfunction in cardiac ageing. Biochim Biophys Acta. DOI: 10.1.016/j.bbabio.2015.0.7.0.09 (2015)
80. E. Marzetti, A. Csiszar, D. Dutta, G. Balagopal, R. Calvani, C. Leeuwenburgh: Role of mitochondrial dysfunction and altered autophagy in cardiovascular aging and disease: from mechanisms to therapeutics. Am J Physiol Heart Circ Physiol 305(4), 459-476 (2013) DOI: 10.1152/ajpheart.00936.2012
81. P. Dromparis, E. D. Michelakis: Mitochondria in vascular health and disease. Annu Rev Physiol 75, 95-126 (2013) DOI: 10.1146/annurev-physiol-030212-183804
82. H. Tsutsui, S. Kinugawa, S. Matsushima: Mitochondrial oxidative stress and dysfunction in myocardial remodelling. Cardiovasc Res 81(3), 449-456 (2009) DOI: 10.1093/cvr/cvn280
83. S. E. Wohlgemuth, R. Calvani, E. Marzetti: The interplay between autophagy and mitochondrial dysfunction in oxidative stressinduced cardiac aging and pathology. J Mol Cell Cardiol 71, 62-70 (2014) DOI: 10.1016/j.yjmcc.2014.03.007
84. C. Villeneuve, C. Guilbeau-Frugier, P. Sicard, O. Lairez, C. Ordener, T. Duparc, D. De Paulis, B. Couderc, O. Spreux-Varoquaux, F. Tortosa, A. Garnier, C. Knauf, P. Valet, E. Borchi, C. Nediani, A. Gharib, M. Ovize, M. B. Delisle, A. Parini, J. Mialet-Perez: p53-PGC-1alpha pathway mediates oxidative mitochondrial damage and cardiomyocyte necrosis induced by monoamine oxidase-A upregulation: role in chronic left ventricular dysfunction in mice. Antioxid Redox Signal 18(1), 5-18 (2013) DOI: 10.1089/ars.2011.4373
85. A. Qu, C. Jiang, M. Xu, Y. Zhang, Y. Zhu, Q. Xu, C. Zhang, X. Wang: PGC-1alpha attenuates neointimal formation via inhibition of vascular smooth muscle cell migration in the injured rat carotid artery. Am J Physiol Cell Physiol 297(3), 645-653 (2009) DOI: 10.1152/ajpcell.00469.2008
86. C. Riehle, A. R. Wende, V. G. Zaha, K. M. Pires, B. Wayment, C. Olsen, H. Bugger, J. Buchanan, X. Wang, A. B. Moreira, T. Doenst, G. Medina-Gomez, S. E. Litwin, C. J. Lelliott, A. Vidal-Puig, E. D. Abel: PGC-1beta deficiency accelerates the transition to heart failure in pressure overload hypertrophy. Circ Res 109(7), 783-793 (2011) DOI: 10.1161/CIRCRESAHA.111.243964
87. J. Ren, L. Pulakat, A. Whaley-Connell, J. R. Sowers: Mitochondrial biogenesis in the metabolic syndrome and cardiovascular disease. J Mol Med (Berl) 88(10), 993-1001 (2010) DOI: 10.1007/s00109-010-0663-9
88. Z. Ungvari, Z. Orosz, N. Labinskyy, A. Rivera, Z. Xiangmin, K. Smith, A. Csiszar: Increased mitochondrial H2O2 production promotes endothelial NF-kappaB activation in aged rat arteries. Am J Physiol Heart Circ Physiol 293(1), 37-47 (2007) DOI: 10.1152/ajpheart.01346.2006
89. U. K. Kim, H. S. Kim, B. H. Oh, M. M. Lee, S. H. Kim, J. J. Chae, H. S. Choi, S. C. Choe, C. C. Lee, Y. B. Park: Analysis of mitochondrial DNA deletions in four chambers of failing human heart: hemodynamic stress, age, and disease are important factors. Basic Res Cardiol 95(2), 163-171 (2000) DOI: 10.1007/s003950050178
90. J. C. Fernández-Checa, A. Fernández, A. Morales, M. Marí, C. García-Ruiz, A. Colell: Oxidative stress and altered mitochondrial function in neurodegenerative diseases: lessons from mouse models. CNS Neurol Disord Drug Targets 9(4), 439-454 (2010) DOI: 10.2174/187152710791556113
91. M. T. Lin, M. F. Beal: Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443, 787-795 (2006) DOI: 10.1038/nature05292
92. E. Lezi, R. H. Swerdlow: Mitochondria in neurodegeneration. Adv Exp Med Biol 942, 269-286 (2012) DOI: 10.1007/978-94-007-2869-1-12
93. G. J. Bennett, T. Doyle, D. Salvemini: Mitotoxicity in distal symmetrical sensory peripheral neuropathies. Nat Rev Neurol 10(6), 326-336 (2014) DOI: 10.1038/nrneurol.2014.77
94. C. Fernández-Moriano, E. González-Burgos, M. P. Gómez-Serranillos: Mitochondriatargeted protective compounds in parkinson's and alzheimer's diseases. Oxid Med Cell Longev 2015, 408927 (2015) DOI: 10.1155/2015/408927
95. D. Sharma, M. S. Kim, S. R. D'Mello: Transcriptome profiling of expression changes during neuronal death by RNA-Seq. Exp Biol Med (Maywood) 240(2), 242-251 (2015) DOI: 10.1177/1535370214551688
96. M. Pinto, C. T. Moraes: Mechanisms linking mtDNA damage and aging. Free Radic Biol Med 85, 250-258 (2015) DOI: 10.1016/j.freeradbiomed.2015.05.005
97. T. G. Rubin, J. D. Gray, B. S. McEwen: Experience and the ever-changing brain: what the transcriptome can reveal. Bioessays 36(11), 1072-1081 (2014) DOI: 10.1002/bies.201400095
98. S. H. Wood, T. Craig, Y. Li, B. Merry, J. P. de Magalhães: Whole transcriptome sequencing of the aging rat brain reveals dynamic RNA changes in the dark matter of the genome. Age (Dordr) 35(3), 763-776 (2013) DOI: 10.1007/s11357-012-9410-1
99. E. Thouvenot, S. Urbach, O. Vigy, M. Séveno, N. Galéotti, G. Nguyen, J. Bockaert, P. Marin: Quantitative proteomic analysis reveals protein expression changes in the murine neuronal secretome during apoptosis. J Proteomics 77, 394-405 (2012) DOI: 10.1016/j.jprot.2012.09.013
100. S. M. Cardoso, M. T. Proença, S. Santos, I. Santana, C. R. Oliveira: Cytochrome C oxidase is decreased in Alzheimer's disease platelets. Neurobiol Aging 25(1), 105-110 (2004) DOI: 10.1016/S0197-4580(03)00033-2
101. D. Orsucci, M. Mancuso, E. C. Ienco, C. Simoncini, G. Siciliano, U. Bonuccelli: Vascular factors and mitochondrial dysfunction: A central role in the pathogenesis of Alzheimer's disease. Curr Neurovasc Re 10(1), 76-80 (2013) DOI: 10.2174/156720213804805972
102. P. H. Reddy: Mitochondrial medicine for aging and neurodegenerative diseases. Neuromolecular Med 10(4), 291-315 (2008) DOI: 10.1007/s12017-008-8044-z
103. D. T. Dexter, P. Jenner: Parkinson disease: from pathology to molecular disease mechanisms. Free Radic Biol Med 62, 132-144 (2013) DOI: 10.1016/j.freeradbiomed.2013.01.018
104. P. H. Gordon: Amyotrophic Lateral Sclerosis: an update for 2013 clinical features, pathophysiology, management and therapeutic trials. Aging Dis 4(5), 295-310 (2013) DOI: 10.14336/AD.2013.0400295
105. M. Wong, L. J. Martin: Skeletal musclerestricted expression of human SOD1 causes motor neuron degeneration in transgenic mice. Hum Mol Genet 19(11), 2284-2302 (2010) DOI: 10.1093/hmg/ddq106
106. S. Millecamps, F. Salachas, C. Cazeneuve, P. Gordon, B. Bricka, A. Camuzat, L. Guillot-Noël, O. Russaouen, G. Bruneteau, P. F. Pradat, N. Le Forestier, N. Vandenberghe, V. Danel-Brunaud, N. Guy, C. Thauvin-Robinet, L. Lacomblez, P. Couratier, D. Hannequin, D. Seilhean, I. Le Ber, P. Corcia, W. Camu, A. Brice, G. Rouleau, E. LeGuern, V. Meininger: SOD1, ANG, VAPB, TARDBP, and FUS mutations in familial amyotrophic lateral sclerosis: genotype-phenotype correlations. J Med Genet 47(8), 554-560 (2010) DOI: 10.1136/jmg.2010.077180
107. A. M. Blokhuis, E. J. Groen, M. Koppers, L. H. van den Berg, R. J. Pasterkamp: Protein aggregation in amyotrophic lateral sclerosis. Acta Neuropathol 125(6), 777-794 (2013) DOI: 10.1007/s00401-013-1125-6
108. M. Gonzalez-Freire, R. Cabo, M. Bernier, S. J. Sollott, E. Fabbri, P. Navas, L. Ferrucci: reconsidering the role of mitochondria in aging. J Gerontol A Biol Sci Med Sci. DOI: 10.1.093/gerona/glv070 (2015)
109. J. Finsterer: Inherited mitochondrial neuropathies. J Neurol Sci 304(1-2), 9-16 (2011) DOI: 10.1016/j.jns.2011.02.012
110. C. Sauvanet, S. Duvezin-Caubet, B. Salin, C. David, A. Massoni-Laporte, J. P. di Rago, M. Rojo: Mitochondrial DNA mutations provoke dominant inhibition of mitochondrial inner membrane fusion. PLoS One 7(11), e49639 (2012) DOI: 10.1371/journal.pone.0049639
111. G. Leszczynska, P. Leonczak, K. Wozniak, A. Malkiewicz: Chemical synthesis of the 5-taurinomethyl(-2-thio)uridine modifiedanticodon arm of the human mitochondrial tRNA(Leu(UUR) and tRNA(Lys). RNA 20(6), 938-947 (2014) DOI: 10.1261/rna.044412.114
112. E. L. Blakely, C. L. Alston, B. Lecky, B. Chakrabarti, G. Falkous, D. M. Turnbull, R. W. Taylor, G. S. Gorman: Distal weakness with respiratory insufficiency caused by the m.8344A G "MERRF" mutation. Neuromuscul Disord 24(6), 533-536 (2014) DOI: 10.1016/j.nmd.2014.03.011
113. E. A. Schroeder, N. Raimundo, G. S. Shadel: Epigenetic silencing mediates mitochondria stress-induced longevity. Cell Metabolism 17, 954-964 (2013) DOI: 10.1016/j.cmet.2013.04.003
114. M. Gonzalez-Freire, R. de Cabo, SA Studenski, L. Ferrucci: The neuromuscular junction: aging at the crossroad between nerves and muscle. Front Aging Neurosci 11(6), 208 (2014) DOI: 10.3389/fnagi.2014.00208
115. A. Bratic, Nils-Göran. Larsson: The role of mitochondria in aging. J Clin Invest 123(3), 951-957 (2013) DOI: 10.1172/JCI64125
116. D. Harman: The aging process (free radicals/evolution/antioxidants/degenerative diseases/longevity). Proc Natl Acad Sci U S A 78, 7124-7128 (1981) DOI: 10.1073/pnas.78.11.7124
117. Y. H. Edrey, AB. Salmon: Revisiting an ageold question regarding oxidative stress. Free Radic Biol Med 71, 368-378 (2014) DOI: 10.1016/j.freeradbiomed.2014.03.038
118. M. J. Lopez-Armada, R. R. Riveiro-Naveira, C. Vaamonde-García MN. Valcárcel-Ares: Mitochondrial dysfunction and the inflammatory response. Mitochondrion 13(2), 106-118 (2013) DOI: 10.1016/j.mito.2013.01.003
119. H. C. Lee, Y. H. Wei: Mitochondria and aging. Adv Exp Med Biol 942, 311-327 (2012) DOI: 10.1007/978-94-007-2869-1-14
120. N. G. Larsson: Somatic mitochondrial DNA mutations in mammalian aging. Annu Rev Biochem 79, 683-706 (2010) DOI: 10.1146/annurev-biochem-060408-093701
121. N. G. Larson: The role of mitochondria in aging. J Clin Invest 123(3), 951-957 (2013) DOI: 10.1172/JCI64125
122. R. de Cabo, D. Carmona-Gutierrez, M. Bernier, M. N. Hall, F. Madeo: The search for anti-aging interventions: from elixirs to fasting regimens. Cell 157, 1515-1526 (2014) DOI: 10.1016/j.cell.2014.05.031
123. J. Finsterer, P. S. Bindu: Therapeutic strategies for mitochondrial disorders. Pediatr Neurol 52, 302-313 (2015) DOI: 10.1016/j.pediatrneurol.2014.06.023
124. C. Kang, E. Chung, G. Diffee, L. L. Ji: Exercise training attenuates aging-associated mitochondrial dysfunction in rat skeletal muscle: role of PGC-1alpha. Exp Gerontol 48(11), 1343-1350 (2013) DOI: 10.1016/j.exger.2013.08.004
125. J. Tamargo, J. López-Sendón: Novel therapeutic targets for the treatment of heart failure. Nat Rev Drug Discov 10(7), 536-555 (2011) DOI: 10.1038/nrd3431
126. S. Messaoudi, F. Azibani, C. Delcayre, F. Jaisser: Aldosterone, mineralocorticoid receptor and heart failure. Mol Cell Endocrinol 350(2), 266-272 (2012) DOI: 10.1016/j.mce.2011.06.038
127. J. H. Lee, T. O. Khor, L. Shu, Z. Y. Su, F. Fuentes, A. T. Kong: Dietary phytochemicals and cancer prevention: Nrf2 signaling, epigenetics, and cell death mechanisms in blocking cancer initiation and progression. Pharmacol Ther 137, 153-171 (2013) DOI: 10.1016/j.pharmthera.2012.09.008
128. M. Edeas, V. Weissig: Targeting mitochondria: Strategies, innovations and challenges the future of medicine will come through mitochondria. Mitochondrion 13, 389-390 (2013) DOI: 10.1016/j.mito.2013.03.009
129. A. Bhargava, N. Bunkar, N. K. Khare, D. Mishra, P. K. Mishra: Nanoengineered strategies to optimize dendritic cells for gastrointestinal tumor immunotherapy: from biology to translational medicine. Nanomedicine (Lond) 9(14), 2187-2202 (2014) DOI: 10.2217/nnm.14.115
130. A. Wongrakpanich, S. M. Geary, M. L. Joiner, M. E. Anderson, A. K. Salem: Mitochondria targeting particles. Nanomedicine (Lond) 9(16), 2531-2543 (2014) DOI: 10.2217/nnm.14.161
131. V. Weissig, S. V. Boddapati, L. Jabr, G. G. D'Souza: Mitochondria-specific nanotechnology. Nanomedicine (Lond) 2(3), 275-285 (2007) DOI: 10.2217/17435889.2.3.275
132. A. Gupta, S. Das, S. Seal: Redoxactive nanoparticles in combating neurodegeneration. Nanomedicine (Lond) 9(18), 2725-2728 (2014) DOI: 10.2217/nnm.14.180
133. F. Strappazzona, F. Cecconia: The multifaceted mitochondrion: An attractive candidate for therapeutic strategies. Pharmacol Research DOI: 10.1.016/j.phrs.2015.0.3.0.07 (2015)
134. D. Vestweber, G. Schatz: DNA-protein conjugates can enter mitochondria via the protein import pathway. Nature 338, 170-172 (1989) DOI: 10.1038/338170a0
135. P. Seibel, J. Trappe, G. Villani, T. Klopstock, S. Papa, H. Reichmann: Transfection of mitochondria: strategy towards a gene therapy of mitochondrial DNA diseases. Nucleic Acids Res 23, 10-17 (1995) DOI: 10.1093/nar/23.1.10
136. A. Flierl, C. Jackson, B. Cottrell, D. Murdock, P. Seibel, D. C. Wallace: Targeted delivery of DNA to the mitochondrial compartment via import sequence-conjugated peptide nucleic acid. Mol Ther 7, 550-557 (2003) DOI: 10.1016/S1525-0016(03)00037-6
137. V. Weissig, V. P. Torchilin: Drug and DNA delivery to mitochondria. Adv Drug Deliv Rev 49, 1-2 (2001) DOI: 10.1016/S0169-409X(01)00122-3
138. A. I. García-Péreza, E. Galeanob, E. Nietoa, P. Sancho: Dequalinium induces human leukemia cell death by affecting the redox balance. Leuk Res 35, 1395-1401 (2011) DOI: 10.1016/j.leukres.2011.03.012
139. G. G. D'Souza, R. Rammohan, S. M. Cheng, V. P. Torchilin, V. Weissig: DQAsome mediated delivery of plasmid DNA toward mitochondria in living cells. J Control Release 92, 189-197 (2003) DOI: 10.1016/S0168-3659(03)00297-9
140. G. G. D'Souza, S. M. Cheng, S. V. Boddapati, R. W. Horobin, V. Weissig: Nanocarrier assisted sub-cellular targeting to the site of mitochondria improves the pro-apoptotic activity of paclitaxel. J Drug Target 16, 578-585 (2008) DOI: 10.1080/10611860802228855
141. S. A. Durazo, U. B. Kompella: Functionalized nanosystems for targeted mitochondrial delivery. Mitochondrion 12(2), 190-201 (2012) DOI: 10.1016/j.mito.2011.11.001
142. Y. Inoki: Proteoliposomes colocalized with endogenous mitochondria in mouse fertilized egg. Biochem Biophys Res Commun 278, 183-191(2000) DOI: 10.1006/bbrc.2000.3765
143. Y. Yamada, H. Akita, H. Kamiya, K. Kogure, T. Yamamoto, Y. Shinohara, K. Yamashita, H. Kobayashi, H. Kikuchi, H. Harashima: MITOPorter: A liposome-based carrier system for delivery of macromolecules into mitochondria via membrane fusion. Biochim Biophys Acta 1778, 423-432 (2008) DOI: 10.1016/j.bbamem.2007.11.002
144. M. D. Brand, D. G. Nicholls: Assessing mitochondrial dysfunction in cells. Biochem J 435, 297-312(2011) DOI: 10.1042/BJ20110162
145. S. V. Boddapati, G. G. D'Souza, S. Erdogan, V. P. Torchilin, V. Weissig: Organelle-targeted nanocarriers: specific delivery of liposomal ceramide to mitochondria enhances its cytotoxicity in vitro and in vivo. Nano Lett 8, 2559-2563 (2008) DOI: 10.1021/nl801908y
146. Y. Yasuzaki, Y. Yamada, H. Harashima: Mitochondrial matrix delivery using MITO Porter, a liposome-based carrier that specifies fusion with mitochondrial membranes. Biochem Biophys Res Commun 397, 181-186 (2010) DOI: 10.1016/j.bbrc.2010.05.070
147. Y. Yamada, R. Furukawa, Y. Yasuzaki, H. Harashima: Dual function MITO-Porter, a nano carrier integrating both efficient cytoplasmic delivery and mitochondrial macromolecule delivery. Mol Ther 19(8), 1449-1456 (2011) DOI: 10.1038/mt.2011.99
148. Y. Yamada, K. Nakamura, R. Furukawa, E. Kawamura, T. Moriwaki, K. Matsumoto, K. Okuda, M. Shindo, H. Harashima: Mitochondrial delivery of bongkrekic acid using a MITO-porter prevents the induction of apoptosis in human hela cells. J Pharm Sci 102, 1008-1015 (2013) DOI: 10.1002/jps.23442
149. M. K. Reddy, L. Wu, W. Kou, A. Ghorpade, V. Labhasetwar: Superoxide dismutase-loaded PLGA nanoparticles protect cultured human neurons under oxidative stress. Appl Biochem Biotechnol 151, 565-577 (2008) DOI: 10.1007/s12010-008-8232-1
150. S. Marrache, S. Tundup, D. A. Harn, S. Dhar: Ex vivo programming of dendritic cells by mitochondria-targeted nanoparticles to produce interferon-gamma for cancer immunotherapy. ACS Nano 7(8), 7392-7402 (2013) DOI: 10.1021/nn403158n
151. S. Biswas, N. S. Dodwadkar, A. Piroyan, V. P. Torchilin: Surface conjugation of triphenylphosphonium to target poly(amidoamine) dendrimers to mitochondria. Biomaterials 33, 4773-4782 (2012) DOI: 10.1016/j.biomaterials.2012.03.032
152. S. Biswas, N. S. Dodwadkar, P. P. Deshpande, V. P.Torchilin: Liposomes loaded with paclitaxel and modified with novel triphenylphosphonium-PEG-PE conjugate possess low toxicity, target mitochondria and demonstrate enhanced antitumor effects in vitro and in vivo. J Control Release 159, 393-402 (2012) DOI: 10.1016/j.jconrel.2012.01.009
153. S. Marrache, S. Dhar: Engineering of blended nanoparticle platform for delivery of mitochondria-acting therapeutics. Proc Natl Acad Sci U S A 109(40), 16288-16293 (2012) DOI: 10.1073/pnas.1210096109
154. V. Salnikov, Y. O. Lukyanenko, C. A. Frederick, W. J. Lederer, V. Lukyanenko: Probing the outer mitochondrial membrane in cardiac mitochondria with nanoparticles. Biophys J 92, 1058-1071 (2007) DOI: 10.1529/biophysj.106.094318
155. L. Wang, Y. Liu, W. Li, X. Jiang, Y. Ji, X. Wu, L. Xu, Y. Qiu, K. Zhao, T. Wei, Y. Li, Y. Zhao, C. Chen: Selective targeting of gold nanorods at the mitochondria of cancer cells: implications for cancer therapy. Nano Lett 11, 772-780 (2011) DOI: 10.1021/nl103992v
156. T. Paunesku, S. Vogt, B. Lai, J. Maser, N. Stojicevic, K. T. Thurn, C. Osipo, H. Liu, D. Legnini, Z. Wang, C. Lee, G. E. Woloschak. Intracellular distribution of TiO2-DNA oligonucleotide nanoconjugates directed to nucleolus and mitochondria indicates sequence specificity. Nano Lett 7, 596-601 (2007) DOI: 10.1021/nl0624723
157. M. Kajita, K. Hikosaka, M. Iitsuka, A. Kanayama, N. Toshima, Y. Miyamoto: Platinum nanoparticles is a useful scavenger of superoxide anion and hydrogen peroxide. Free Radical Research 41, 615-626 (2007) DOI: 10.1080/10715760601169679
158. M. F. Ross, G. F. Kelso, F. H. Blaikie, A. M. James, H. M. Cocheme, A. Filipovska, T. Da Ros, T. R. Hurd, R. A. Smith, M. P. Murphy: Lipophilic triphenylphosphonium cations as tools in mitochondrial bioenergetics and free radical biology. Biochemistry (Mosc) 70, 222-230 (2005) DOI: 10.1007/s10541-005-0104-5
159. L. B. Chen: Mitochondrial membrane potential in living cells. Annu Rev Cell Biol 4, 155-181 (1988) DOI: 10.1146/annurev.cb.04.110188.001103
160. S. Biswas, N. S. Dodwadkar, P. P. Deshpande, V. P. Torchilin: Liposomes loaded with paclitaxel andmodified with novel triphenylphosphonium-PEG-PE conjugate possess low toxicity, target mitochondria and demonstrate enhanced antitumor effects in vitro and in vivo. J Control Release 159, 393-402 (2012) DOI: 10.1016/j.jconrel.2012.01.009
161. S. Biswas, N. S. Dodwadkar, A. Piroyan, V. P. Torchilin: Surface conjugation of triphenylphosphonium to target poly(amidoamine) dendrimers to mitochondria. Biomaterials 3, 4773-4782 (2012) DOI: 10.1016/j.biomaterials.2012.03.032
162. V. Cuchelkar, P. Kopeckova, J. Kopecek: Novel HPMA copolymer-bound constructs for combined tumor and mitochondrial targeting. Mol Pharm 5, 776-786 (2008) DOI: 10.1021/mp800019g
163. M. L. Jauslin, T. Meier, R. A. Smith, M. P. Murphy: Mitochondria-targeted antioxidants protect Friedreich Ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants. FASEB J 17, 1972-1974 (2003) DOI: 10.1096/fj.03-0240fje
164. J. Kruk, M. Jemiola-Rzeminska, K. Strzalka: Plastoquinol and alpha-tocopherol quinol are more active than ubiquinol and alphatocopherol in inhibition of lipid peroxidation. Chem Phys Lipids 87, 73-80 (1997) DOI: 10.1016/S0009-3084(97)00027-3
165. M. V. Skulachev, Y. N. Antonenko, V. N. Anisimov, B. V. Chernyak, D. A. Cherepanov, V. A. Chistyakov, M. V. Egorov, N. G. Kolosova, G. A. Korshunova, K. G. Lyamzaev, E. Y. Plotnikov, V. A. Roginsky, A. Y. Savchenko, I. I. Severina, F. F. Severin, T. P. Shkurat, V. N. Tashlitsky, K. M. Shidlovsky, M. Y. Vyssokikh, A. A. Zamyatnin Jr, D. B. Zorov, V. P. Skulachev: Mitochondrial-targeted plastoquinone derivatives. Effect on senescence and acute age-related pathologies. Curr Drug Targets 12, 800-826 (2011) DOI: 10.2174/138945011795528859
166. J. S. Armstrong: Mitochondrial medicine: pharmacological targeting of mitochondria in disease. Br J Pharmacol 151, 1154-1165 (2007) DOI: 10.1038/sj.bjp.0707288
167. H. H. Szeto: Cell-permeable,mitochondrialtargeted, peptide antioxidants. AAPS J 8, 277-283 (2006) DOI: 10.1007/BF02854898
168. H. H. Szeto: Mitochondria-targeted peptide antioxidants: novel neuroprotective agents. AAPS J 8, 521-531 (2006) DOI: 10.1208/aapsj080362
169. R. K. Pathak, N. Kolishetti, S. Dhar: Targeted nanoparticles in mitochondrial medicine. WIREs Nanomed Nanobiotechnol 7(3), 315-329 (2015) DOI: 10.1002/wnan.1305
170. K. Zhao, G. M. Zhao, D. Wu, Y. Soong, A. V. Birk, P. W. Schiller, H. H. Szeto: Cellpermeable peptide antioxidants targeted to inner mitochondrial membrane inhibit mitochondrial swelling, oxidative cell death, and reperfusion injury. J Biol Chem 279, 34682-34690 (2004) DOI: 10.1074/jbc.M402999200