메뉴 건너뛰기




Volumn 85, Issue , 2015, Pages 250-258

Mechanisms linking mtDNA damage and aging

Author keywords

Aging; Free radicals; Mitochondria; MtDNA; Mutation

Indexed keywords

FREE RADICAL; MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE;

EID: 84935030624     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2015.05.005     Document Type: Review
Times cited : (153)

References (146)
  • 1
    • 84900534961 scopus 로고    scopus 로고
    • The biochemistry and cell biology of aging: Metabolic regulation through mitochondrial signaling
    • Elsevier Inc. All rights reserved
    • Y.C. Long The biochemistcell biology ossmetabolic regulation through mitochondrial signaling Am. J. Physiol. Endocrinol. Metab. 306 2014 E581 E591
    • (2014) Am. J. Physiol. Endocrinol. Metab. , vol.306 , pp. E52015
    • Long, Y.C.1
  • 2
    • 84899571023 scopus 로고    scopus 로고
    • Revisiting an age-old question regarding oxidative stress
    • Y.H. Edrey, and A.B. Salmon Revisiting an age-old question regarding oxidative stress Free Radic. Biol. Med. 71 2014 368 378
    • (2014) Free Radic. Biol. Med. , vol.71 , pp. 368-378
    • Edrey, Y.H.1    Salmon, A.B.2
  • 3
    • 77049308856 scopus 로고
    • Aging: A theory based on free radical and radiation chemistry
    • D. Harman Aging: a theory based on free radical and radiation chemistry J. Gerontol. 11 1956 298 300
    • (1956) J. Gerontol. , vol.11 , pp. 298-300
    • Harman, D.1
  • 5
    • 34447316414 scopus 로고    scopus 로고
    • Trends in oxidative aging theories
    • F.L. Muller Trends in oxidative aging theories Free Radic. Biol. Med. 43 2007 477 503
    • (2007) Free Radic. Biol. Med. , vol.43 , pp. 477-503
    • Muller, F.L.1
  • 6
    • 0035964315 scopus 로고    scopus 로고
    • Does oxidative damage to DNA increase with age?
    • M.L. Hamilton Does oxidative damage to DNA increase with age? Proc. Natl. Acad. Sci. USA 98 2001 10469 10474
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 10469-10474
    • Hamilton, M.L.1
  • 7
    • 0036628724 scopus 로고    scopus 로고
    • Role of oxidative stress and protein oxidation in the aging process
    • R.S. Sohal Role of oxidative stress and protein oxidation in the aging process Free Radic. Biol. Med. 33 2002 37 44
    • (2002) Free Radic. Biol. Med. , vol.33 , pp. 37-44
    • Sohal, R.S.1
  • 8
    • 84897496274 scopus 로고    scopus 로고
    • The fine line between lifespan extension and shortening in response to caloric restriction
    • K. Szafranski, and K. Mekhail The fine line between lifespan extension and shortening in response to caloric restriction Nucleus 5 2014 1
    • (2014) Nucleus , vol.5 , pp. 1
    • Szafranski, K.1    Mekhail, K.2
  • 9
    • 33646389796 scopus 로고    scopus 로고
    • Bioenergetic aspects of apoptosis, necrosis and mitoptosis
    • V.P. Skulachev Bioenergetic aspects of apoptosis, necrosis and mitoptosis Apoptosis 11 2006 473 485
    • (2006) Apoptosis , vol.11 , pp. 473-485
    • Skulachev, V.P.1
  • 10
    • 33847059997 scopus 로고    scopus 로고
    • The mitochondrial energy transduction system and the aging process
    • A. Navarro, and A. Boveris The mitochondrial energy transduction system and the aging process Am. J. Physiol. Cell Physiol 292 2007 C670 C686
    • (2007) Am. J. Physiol. Cell Physiol , vol.292 , pp. C670-C686
    • Navarro, A.1    Boveris, A.2
  • 11
    • 84874591240 scopus 로고    scopus 로고
    • The role of mitochondria in aging
    • A. Bratic, and N.G. Larsson The role of mitochondria in aging J. Clin. Invest. 123 2013 951 957
    • (2013) J. Clin. Invest. , vol.123 , pp. 951-957
    • Bratic, A.1    Larsson, N.G.2
  • 12
    • 0034234773 scopus 로고    scopus 로고
    • Oxidative capacity and ageing in human muscle
    • K.E. Conley, S.A. Jubrias, and P.C. Esselman Oxidative capacity and ageing in human muscle J. Physiol. 526 2000 203 210
    • (2000) J. Physiol. , vol.526 , pp. 203-210
    • Conley, K.E.1    Jubrias, S.A.2    Esselman, P.C.3
  • 13
    • 17244363631 scopus 로고    scopus 로고
    • Decline in skeletal muscle mitochondrial function with aging in humans
    • K.R. Short Decline in skeletal muscle mitochondrial function with aging in humans Proc. Natl. Acad. Sci. USA 102 2005 5618 5623
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 5618-5623
    • Short, K.R.1
  • 14
    • 0032845895 scopus 로고    scopus 로고
    • Mitochondrial respiratory chain activity in the human brain as a function of age
    • J. Ojaimi Mitochondrial respiratory chain activity in the human brain as a function of age Mech. Ageing Dev. 111 1999 39 47
    • (1999) Mech. Ageing Dev. , vol.111 , pp. 39-47
    • Ojaimi, J.1
  • 15
    • 0035984909 scopus 로고    scopus 로고
    • Regulation of mitochondrial D-loops by transcription factor A and single-stranded DNA-binding protein
    • C. Takamatsu Regulation of mitochondrial D-loops by transcription factor A and single-stranded DNA-binding protein EMBO Rep. 3 2002 451 456
    • (2002) EMBO Rep. , vol.3 , pp. 451-456
    • Takamatsu, C.1
  • 17
  • 18
    • 63449105579 scopus 로고    scopus 로고
    • Methylation of 12S rRNA is necessary for in vivo stability of the small subunit of the mammalian mitochondrial ribosome
    • M.D. Metodiev Methylation of 12S rRNA is necessary for in vivo stability of the small subunit of the mammalian mitochondrial ribosome Cell Metab. 9 2009 386 397
    • (2009) Cell Metab. , vol.9 , pp. 386-397
    • Metodiev, M.D.1
  • 19
    • 2342429459 scopus 로고    scopus 로고
    • DNA polymerase gamma, the mitochondrial replicase
    • L.S. Kaguni DNA polymerase gamma, the mitochondrial replicase Annu. Rev. Biochem. 73 2004 293 320
    • (2004) Annu. Rev. Biochem. , vol.73 , pp. 293-320
    • Kaguni, L.S.1
  • 20
    • 3242739284 scopus 로고    scopus 로고
    • Reconstitution of a minimal mtDNA replisome in vitro
    • J.A. Korhonen Reconstitution of a minimal mtDNA replisome in vitro EMBO J. 23 2004 2423 2429
    • (2004) EMBO J. , vol.23 , pp. 2423-2429
    • Korhonen, J.A.1
  • 22
    • 0038709292 scopus 로고    scopus 로고
    • Composition and dynamics of human mitochondrial nucleoids
    • N. Garrido Composition and dynamics of human mitochondrial nucleoids Mol. Biol. Cell 14 2003 1583 1596
    • (2003) Mol. Biol. Cell , vol.14 , pp. 1583-1596
    • Garrido, N.1
  • 23
    • 2442431673 scopus 로고    scopus 로고
    • Mitochondrial transcription factor A regulates mtDNA copy number in mammals
    • M.I. Ekstrand Mitochondrial transcription factor A regulates mtDNA copy number in mammals Hum. Mol. Genet. 13 2004 935 944
    • (2004) Hum. Mol. Genet. , vol.13 , pp. 935-944
    • Ekstrand, M.I.1
  • 24
    • 80051972817 scopus 로고    scopus 로고
    • Super-resolution microscopy reveals that mammalian mitochondrial nucleoids have a uniform size and frequently contain a single copy of mtDNA
    • C. Kukat Super-resolution microscopy reveals that mammalian mitochondrial nucleoids have a uniform size and frequently contain a single copy of mtDNA Proc. Natl. Acad. Sci. USA 108 2011 13534 13539
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 13534-13539
    • Kukat, C.1
  • 25
    • 84866729278 scopus 로고    scopus 로고
    • Minimizing the damage: Repair pathways keep mitochondrial DNA intact
    • L. Kazak, A. Reyes, and I.J. Holt Minimizing the damage: repair pathways keep mitochondrial DNA intact Nat. Rev. Mol. Cell Biol. 13 2012 659 671
    • (2012) Nat. Rev. Mol. Cell Biol. , vol.13 , pp. 659-671
    • Kazak, L.1    Reyes, A.2    Holt, I.J.3
  • 26
    • 32444434993 scopus 로고    scopus 로고
    • The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase
    • V. Vartanian The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase Proc. Natl. Acad. Sci. USA 103 2006 1864 1869
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 1864-1869
    • Vartanian, V.1
  • 27
    • 79251647522 scopus 로고    scopus 로고
    • Human AP endonuclease (APE1/Ref-1) and its acetylation regulate YB-1-p300 recruitment and RNA polymerase II loading in the drug-induced activation of multidrug resistance gene MDR1
    • S. Sengupta Human AP endonuclease (APE1/Ref-1) and its acetylation regulate YB-1-p300 recruitment and RNA polymerase II loading in the drug-induced activation of multidrug resistance gene MDR1 Oncogene 30 2011 482 493
    • (2011) Oncogene , vol.30 , pp. 482-493
    • Sengupta, S.1
  • 29
    • 84906937543 scopus 로고    scopus 로고
    • Mitochondrial function and mitochondrial DNA maintenance with advancing age
    • A.I. Gaziev, S. Abdullaev, and A. Podlutsky Mitochondrial function and mitochondrial DNA maintenance with advancing age Biogerontology 15 2014 417 438
    • (2014) Biogerontology , vol.15 , pp. 417-438
    • Gaziev, A.I.1    Abdullaev, S.2    Podlutsky, A.3
  • 30
    • 33846580517 scopus 로고    scopus 로고
    • Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis
    • R.M. Reznick Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis Cell Metab. 5 2007 151 156
    • (2007) Cell Metab. , vol.5 , pp. 151-156
    • Reznick, R.M.1
  • 31
    • 84863724082 scopus 로고    scopus 로고
    • Age associated low mitochondrial biogenesis may be explained by lack of response of PGC-1alpha to exercise training
    • F. Derbre Age associated low mitochondrial biogenesis may be explained by lack of response of PGC-1alpha to exercise training Age (Dordrecht) 34 2012 669 679
    • (2012) Age (Dordrecht) , vol.34 , pp. 669-679
    • Derbre, F.1
  • 32
    • 84860445228 scopus 로고    scopus 로고
    • Increased mitochondrial biogenesis in muscle improves aging phenotypes in the mtDNA mutator mouse
    • L.M. Dillon Increased mitochondrial biogenesis in muscle improves aging phenotypes in the mtDNA mutator mouse Hum. Mol. Genet. 21 2012 2288 2297
    • (2012) Hum. Mol. Genet. , vol.21 , pp. 2288-2297
    • Dillon, L.M.1
  • 33
    • 33744912521 scopus 로고    scopus 로고
    • Mitochondrial and nuclear DNA-repair capacity of various brain regions in mouse is altered in an age-dependent manner
    • S.Z. Imam Mitochondrial and nuclear DNA-repair capacity of various brain regions in mouse is altered in an age-dependent manner Neurobiol. Aging 27 2006 1129 1136
    • (2006) Neurobiol. Aging , vol.27 , pp. 1129-1136
    • Imam, S.Z.1
  • 34
    • 77953036663 scopus 로고    scopus 로고
    • Age- and tissue-specific changes in mitochondrial and nuclear DNA base excision repair activity in mice: Susceptibility of skeletal muscles to oxidative injury
    • B. Szczesny, A.W. Tann, and S. Mitra Age- and tissue-specific changes in mitochondrial and nuclear DNA base excision repair activity in mice: susceptibility of skeletal muscles to oxidative injury Mech. Ageing Dev. 131 2010 330 337
    • (2010) Mech. Ageing Dev. , vol.131 , pp. 330-337
    • Szczesny, B.1    Tann, A.W.2    Mitra, S.3
  • 35
    • 84899647071 scopus 로고    scopus 로고
    • A comprehensive approach to determining BER capacities and their change with aging in Drosophila melanogaster mitochondria by oligonucleotide microarray
    • I. Garreau-Balandier A comprehensive approach to determining BER capacities and their change with aging in Drosophila melanogaster mitochondria by oligonucleotide microarray FEBS Lett. 588 2014 1673 1679
    • (2014) FEBS Lett. , vol.588 , pp. 1673-1679
    • Garreau-Balandier, I.1
  • 36
    • 0036316413 scopus 로고    scopus 로고
    • Age-dependent decline of DNA repair activity for oxidative lesions in rat brain mitochondria
    • D. Chen Age-dependent decline of DNA repair activity for oxidative lesions in rat brain mitochondria J. Neurochem. 81 2002 1273 1284
    • (2002) J. Neurochem. , vol.81 , pp. 1273-1284
    • Chen, D.1
  • 38
    • 84869030015 scopus 로고    scopus 로고
    • Fusion and fission: Interlinked processes critical for mitochondrial health
    • D.C. Chan Fusion and fission: interlinked processes critical for mitochondrial health Annu. Rev. Genet. 46 2012 265 287
    • (2012) Annu. Rev. Genet. , vol.46 , pp. 265-287
    • Chan, D.C.1
  • 39
    • 84909619435 scopus 로고    scopus 로고
    • The regulation of mitochondrial dynamics
    • S. Hoppins The regulation of mitochondrial dynamics Curr. Opin. Cell Biol. 29C 2014 46 52
    • (2014) Curr. Opin. Cell Biol. , vol.29 C , pp. 46-52
    • Hoppins, S.1
  • 40
    • 84874996381 scopus 로고    scopus 로고
    • Quality control of mitochondria during aging: Is there a good and a bad side of mitochondrial dynamics?
    • M.T. Figge, H.D. Osiewacz, and A.S. Reichert Quality control of mitochondria during aging: is there a good and a bad side of mitochondrial dynamics? Bioessays 35 2013 314 322
    • (2013) Bioessays , vol.35 , pp. 314-322
    • Figge, M.T.1    Osiewacz, H.D.2    Reichert, A.S.3
  • 41
    • 77953357982 scopus 로고    scopus 로고
    • Impaired quality control of mitochondria: Aging from a new perspective
    • T.A. Weber, and A.S. Reichert Impaired quality control of mitochondria: aging from a new perspective Exp. Gerontol. 45 2010 503 511
    • (2010) Exp. Gerontol. , vol.45 , pp. 503-511
    • Weber, T.A.1    Reichert, A.S.2
  • 42
    • 84863229947 scopus 로고    scopus 로고
    • Loss of autophagy in hypothalamic POMC neurons impairs lipolysis
    • S. Kaushik Loss of autophagy in hypothalamic POMC neurons impairs lipolysis EMBO Rep. 13 2012 258 265
    • (2012) EMBO Rep. , vol.13 , pp. 258-265
    • Kaushik, S.1
  • 43
    • 0034875011 scopus 로고    scopus 로고
    • Age-related changes in the autophagic proteolysis of rat isolated liver cells: Effects of antiaging dietary restrictions
    • A. Donati Age-related changes in the autophagic proteolysis of rat isolated liver cells: effects of antiaging dietary restrictions J. Gerontol. A Biol. Sci. Med. Sci 56 2001 B375 B383
    • (2001) J. Gerontol. A Biol. Sci. Med. Sci , vol.56 , pp. B375-B383
    • Donati, A.1
  • 44
    • 79959354999 scopus 로고    scopus 로고
    • Mitochondria and the autophagy-inflammation-cell death axis in organismal aging
    • D.R. Green, L. Galluzzi, and G. Kroemer Mitochondria and the autophagy-inflammation-cell death axis in organismal aging Science 333 2011 1109 1112
    • (2011) Science , vol.333 , pp. 1109-1112
    • Green, D.R.1    Galluzzi, L.2    Kroemer, G.3
  • 46
    • 13244292394 scopus 로고    scopus 로고
    • Time-course of mitochondrial gene expressions in mice brains: Implications for mitochondrial dysfunction, oxidative damage, and cytochrome c in aging
    • M. Manczak Time-course of mitochondrial gene expressions in mice brains: implications for mitochondrial dysfunction, oxidative damage, and cytochrome c in aging J. Neurochem. 92 2005 494 504
    • (2005) J. Neurochem. , vol.92 , pp. 494-504
    • Manczak, M.1
  • 47
    • 0024541837 scopus 로고
    • Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases
    • A.W. Linnane Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases Lancet 1 1989 642 645
    • (1989) Lancet , vol.1 , pp. 642-645
    • Linnane, A.W.1
  • 48
    • 0023944266 scopus 로고
    • Studies of sequence heterogeneity of mitochondrial DNA from rat and mouse tissues: Evidence for an increased frequency of deletions/additions with aging
    • L. Piko, A.J. Hougham, and K.J. Bulpitt Studies of sequence heterogeneity of mitochondrial DNA from rat and mouse tissues: evidence for an increased frequency of deletions/additions with aging Mech. Ageing Dev. 43 1988 279 293
    • (1988) Mech. Ageing Dev. , vol.43 , pp. 279-293
    • Piko, L.1    Hougham, A.J.2    Bulpitt, K.J.3
  • 49
    • 0025674177 scopus 로고
    • Detection of a specific mitochondrial DNA deletion in tissues of older humans
    • G.A. Cortopassi, and N. Arnheim Detection of a specific mitochondrial DNA deletion in tissues of older humans Nucleic Acids Res. 18 1990 6927 6933
    • (1990) Nucleic Acids Res. , vol.18 , pp. 6927-6933
    • Cortopassi, G.A.1    Arnheim, N.2
  • 50
    • 0023813744 scopus 로고
    • Deletions of mitochondrial DNA in Kearns-Sayre syndrome
    • M. Zeviani Deletions of mitochondrial DNA in Kearns-Sayre syndrome Neurology 38 1988 1339 1346
    • (1988) Neurology , vol.38 , pp. 1339-1346
    • Zeviani, M.1
  • 51
    • 0036258718 scopus 로고    scopus 로고
    • Ageing muscle: Clonal expansions of mitochondrial DNA point mutations and deletions cause focal impairment of mitochondrial function
    • G. Fayet Ageing muscle: clonal expansions of mitochondrial DNA point mutations and deletions cause focal impairment of mitochondrial function Neuromuscul. Disord 12 2002 484 493
    • (2002) Neuromuscul. Disord , vol.12 , pp. 484-493
    • Fayet, G.1
  • 52
    • 0027021442 scopus 로고
    • Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain
    • N.W. Soong Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain Nat. Genet. 2 1992 318 323
    • (1992) Nat. Genet. , vol.2 , pp. 318-323
    • Soong, N.W.1
  • 53
    • 33646351299 scopus 로고    scopus 로고
    • Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons
    • Y. Kraytsberg Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons Nat. Genet. 38 2006 518 520
    • (2006) Nat. Genet. , vol.38 , pp. 518-520
    • Kraytsberg, Y.1
  • 54
    • 84892698220 scopus 로고    scopus 로고
    • Somatic mtDNA mutation spectra in the aging human putamen
    • S.L. Williams Somatic mtDNA mutation spectra in the aging human putamen PLoS Genet. 9 2013 e1003990
    • (2013) PLoS Genet. , vol.9 , pp. e1003990
    • Williams, S.L.1
  • 55
    • 79960079717 scopus 로고    scopus 로고
    • The striatum is highly susceptible to mitochondrial oxidative phosphorylation dysfunctions
    • A.M. Pickrell The striatum is highly susceptible to mitochondrial oxidative phosphorylation dysfunctions J. Neurosci. 31 2011 9895 9904
    • (2011) J. Neurosci. , vol.31 , pp. 9895-9904
    • Pickrell, A.M.1
  • 56
    • 84859842601 scopus 로고    scopus 로고
    • Regional susceptibilities to mitochondrial dysfunctions in the CNS
    • M. Pinto, A.M. Pickrell, and C.T. Moraes Regional susceptibilities to mitochondrial dysfunctions in the CNS Biol. Chem. 393 2012 275 281
    • (2012) Biol. Chem. , vol.393 , pp. 275-281
    • Pinto, M.1    Pickrell, A.M.2    Moraes, C.T.3
  • 57
    • 61849118621 scopus 로고    scopus 로고
    • Mechanisms of formation and accumulation of mitochondrial DNA deletions in aging neurons
    • H. Fukui, and C.T. Moraes Mechanisms of formation and accumulation of mitochondrial DNA deletions in aging neurons Hum. Mol. Genet. 18 2009 1028 1036
    • (2009) Hum. Mol. Genet. , vol.18 , pp. 1028-1036
    • Fukui, H.1    Moraes, C.T.2
  • 58
    • 33747639275 scopus 로고    scopus 로고
    • Conserved sequence box II directs transcription termination and primer formation in mitochondria
    • X.H. Pham Conserved sequence box II directs transcription termination and primer formation in mitochondria J. Biol. Chem. 281 2006 24647 24652
    • (2006) J. Biol. Chem. , vol.281 , pp. 24647-24652
    • Pham, X.H.1
  • 59
    • 0347600946 scopus 로고    scopus 로고
    • Mitochondrial DNA mutations in human colonic crypt stem cells
    • R.W. Taylor Mitochondrial DNA mutations in human colonic crypt stem cells J. Clin. Invest. 112 2003 1351 1360
    • (2003) J. Clin. Invest. , vol.112 , pp. 1351-1360
    • Taylor, R.W.1
  • 60
    • 0033595684 scopus 로고    scopus 로고
    • Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication
    • Y. Michikawa Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication Science 286 1999 774 779
    • (1999) Science , vol.286 , pp. 774-779
    • Michikawa, Y.1
  • 61
    • 84901831524 scopus 로고    scopus 로고
    • MtDNA mutations in human aging and longevity: Controversies and new perspectives opened by high-throughput technologies
    • F. Sevini mtDNA mutations in human aging and longevity: controversies and new perspectives opened by high-throughput technologies Exp. Gerontol. 56 2014 234 244
    • (2014) Exp. Gerontol. , vol.56 , pp. 234-244
    • Sevini, F.1
  • 62
    • 0031885843 scopus 로고    scopus 로고
    • Role of mitochondrial DNA mutations in human aging: Implications for the central nervous system and muscle
    • E.J. Brierley Role of mitochondrial DNA mutations in human aging: implications for the central nervous system and muscle Ann. Neurol. 43 1998 217 223
    • (1998) Ann. Neurol. , vol.43 , pp. 217-223
    • Brierley, E.J.1
  • 63
    • 0034327572 scopus 로고    scopus 로고
    • The age-related accumulation of a mitochondrial DNA control region mutation in muscle, but not brain, detected by a sensitive PNA-directed PCR clamping based method
    • D.G. Murdock, N.C. Christacos, and D.C. Wallace The age-related accumulation of a mitochondrial DNA control region mutation in muscle, but not brain, detected by a sensitive PNA-directed PCR clamping based method Nucleic Acids Res. 28 2000 4350 4355
    • (2000) Nucleic Acids Res. , vol.28 , pp. 4350-4355
    • Murdock, D.G.1    Christacos, N.C.2    Wallace, D.C.3
  • 64
    • 0037444769 scopus 로고    scopus 로고
    • Mitochondrial threshold effects
    • R. Rossignol Mitochondrial threshold effects Biochem. J. 370 2003 751 762
    • (2003) Biochem. J. , vol.370 , pp. 751-762
    • Rossignol, R.1
  • 65
    • 0024580556 scopus 로고
    • Decline in skeletal muscle mitochondrial respiratory chain function: Possible factor in ageing
    • I. Trounce, E. Byrne, and S. Marzuki Decline in skeletal muscle mitochondrial respiratory chain function: possible factor in ageing Lancet 1 1989 637 639
    • (1989) Lancet , vol.1 , pp. 637-639
    • Trounce, I.1    Byrne, E.2    Marzuki, S.3
  • 66
    • 84885217983 scopus 로고    scopus 로고
    • Updating the mitochondrial free radical theory of aging: An integrated view, key aspects, and confounding concepts
    • G. Barja Updating the mitochondrial free radical theory of aging: an integrated view, key aspects, and confounding concepts Antioxid. Redox Signaling 19 2013 1420 1445
    • (2013) Antioxid. Redox Signaling , vol.19 , pp. 1420-1445
    • Barja, G.1
  • 67
    • 84874931751 scopus 로고    scopus 로고
    • Reactive oxygen species and the free radical theory of aging
    • S.I. Liochev Reactive oxygen species and the free radical theory of aging Free Radic. Biol. Med. 60 2013 1 4
    • (2013) Free Radic. Biol. Med. , vol.60 , pp. 1-4
    • Liochev, S.I.1
  • 68
    • 84867804362 scopus 로고    scopus 로고
    • Mitochondria as sources and targets of damage in cellular aging
    • M.C. Gomez-Cabrera Mitochondria as sources and targets of damage in cellular aging Clin. Chem. Lab. Med. 50 2012 1287 1295
    • (2012) Clin. Chem. Lab. Med. , vol.50 , pp. 1287-1295
    • Gomez-Cabrera, M.C.1
  • 69
    • 80053124673 scopus 로고    scopus 로고
    • Taking a good look at free radicals in the aging process
    • S. Hekimi, J. Lapointe, and Y. Wen Taking a good look at free radicals in the aging process Trends Cell Biol. 21 2011 569 576
    • (2011) Trends Cell Biol. , vol.21 , pp. 569-576
    • Hekimi, S.1    Lapointe, J.2    Wen, Y.3
  • 70
    • 58249093939 scopus 로고    scopus 로고
    • How mitochondria produce reactive oxygen species
    • M.P. Murphy How mitochondria produce reactive oxygen species Biochem. J. 417 2009 1 13
    • (2009) Biochem. J. , vol.417 , pp. 1-13
    • Murphy, M.P.1
  • 71
    • 0021996572 scopus 로고
    • Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria
    • J.F. Turrens, A. Alexandre, and A.L. Lehninger Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria Arch. Biochem. Biophys. 237 1985 408 414
    • (1985) Arch. Biochem. Biophys. , vol.237 , pp. 408-414
    • Turrens, J.F.1    Alexandre, A.2    Lehninger, A.L.3
  • 72
    • 0036710886 scopus 로고    scopus 로고
    • Mechanisms of aging: An appraisal of the oxidative stress hypothesis
    • R.S. Sohal, R.J. Mockett, and W.C. Orr Mechanisms of aging: an appraisal of the oxidative stress hypothesis Free Radic. Biol. Med. 33 2002 575 586
    • (2002) Free Radic. Biol. Med. , vol.33 , pp. 575-586
    • Sohal, R.S.1    Mockett, R.J.2    Orr, W.C.3
  • 73
    • 0344513852 scopus 로고    scopus 로고
    • Mitochondrial generation of reactive oxygen species and its role in aerobic life
    • M. Inoue Mitochondrial generation of reactive oxygen species and its role in aerobic life Curr. Med. Chem. 10 2003 2495 2505
    • (2003) Curr. Med. Chem. , vol.10 , pp. 2495-2505
    • Inoue, M.1
  • 74
    • 0015319592 scopus 로고
    • The biologic clock: The mitochondria?
    • D. Harman The biologic clock: the mitochondria? J. Am. Geriatr. Soc 20 1972 145 147
    • (1972) J. Am. Geriatr. Soc , vol.20 , pp. 145-147
    • Harman, D.1
  • 75
    • 84877922143 scopus 로고    scopus 로고
    • The role of mitochondrial DNA mutations and free radicals in disease and ageing
    • M. Lagouge, and N.G. Larsson The role of mitochondrial DNA mutations and free radicals in disease and ageing J. Intern. Med. 273 2013 529 543
    • (2013) J. Intern. Med. , vol.273 , pp. 529-543
    • Lagouge, M.1    Larsson, N.G.2
  • 76
    • 0023811053 scopus 로고
    • Normal oxidative damage to mitochondrial and nuclear DNA is extensive
    • C. Richter, J.W. Park, and B.N. Ames Normal oxidative damage to mitochondrial and nuclear DNA is extensive Proc. Natl. Acad. Sci. USA 85 1988 6465 6467
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 6465-6467
    • Richter, C.1    Park, J.W.2    Ames, B.N.3
  • 77
    • 0033535365 scopus 로고    scopus 로고
    • Endogenous oxidative damage of mtDNA
    • K.B. Beckman, and B.N. Ames Endogenous oxidative damage of mtDNA Mutat. Res. 424 1999 51 58
    • (1999) Mutat. Res. , vol.424 , pp. 51-58
    • Beckman, K.B.1    Ames, B.N.2
  • 78
    • 0035872902 scopus 로고    scopus 로고
    • A reliable assessment of 8-oxo-2-deoxyguanosine levels in nuclear and mitochondrial DNA using the sodium iodide method to isolate DNA
    • M.L. Hamilton A reliable assessment of 8-oxo-2-deoxyguanosine levels in nuclear and mitochondrial DNA using the sodium iodide method to isolate DNA Nucleic Acids Res. 29 2001 2117 2126
    • (2001) Nucleic Acids Res. , vol.29 , pp. 2117-2126
    • Hamilton, M.L.1
  • 79
    • 0032565577 scopus 로고    scopus 로고
    • Mutagenicity and repair of oxidative DNA damage: Insights from studies using defined lesions
    • D. Wang, D.A. Kreutzer, and J.M. Essigmann Mutagenicity and repair of oxidative DNA damage: insights from studies using defined lesions Mutat. Res. 400 1998 99 115
    • (1998) Mutat. Res. , vol.400 , pp. 99-115
    • Wang, D.1    Kreutzer, D.A.2    Essigmann, J.M.3
  • 80
    • 34047116291 scopus 로고    scopus 로고
    • Mitochondrial point mutations do not limit the natural lifespan of mice
    • M. Vermulst Mitochondrial point mutations do not limit the natural lifespan of mice Nat. Genet. 39 2007 540 543
    • (2007) Nat. Genet. , vol.39 , pp. 540-543
    • Vermulst, M.1
  • 81
    • 84901735727 scopus 로고    scopus 로고
    • Oxidative stress is not a major contributor to somatic mitochondrial DNA mutations
    • L.S. Itsara Oxidative stress is not a major contributor to somatic mitochondrial DNA mutations PLoS Genet. 10 2014 e1003974
    • (2014) PLoS Genet. , vol.10 , pp. e1003974
    • Itsara, L.S.1
  • 82
    • 84884686924 scopus 로고    scopus 로고
    • Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage
    • S.R. Kennedy Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage PLoS Genet. 9 2013 e1003794
    • (2013) PLoS Genet. , vol.9 , pp. e1003794
    • Kennedy, S.R.1
  • 83
    • 50249094970 scopus 로고    scopus 로고
    • The mitochondrial free radical theory of ageing - Where do we stand?
    • J. Gruber, S. Schaffer, and B. Halliwell The mitochondrial free radical theory of ageing - where do we stand? Front. Biosci 13 2008 6554 6579
    • (2008) Front. Biosci , vol.13 , pp. 6554-6579
    • Gruber, J.1    Schaffer, S.2    Halliwell, B.3
  • 84
    • 0025309791 scopus 로고
    • Mitochondrial mutations may increase oxidative stress: Implications for carcinogenesis and aging?
    • B. Bandy, and A.J. Davison Mitochondrial mutations may increase oxidative stress: implications for carcinogenesis and aging? Free Radic. Biol. Med 8 1990 523 539
    • (1990) Free Radic. Biol. Med , vol.8 , pp. 523-539
    • Bandy, B.1    Davison, A.J.2
  • 85
    • 0030875420 scopus 로고    scopus 로고
    • Oxidative phosphorylation dysfunction does not increase the rate of accumulation of age-related mtDNA deletions in skeletal muscle
    • C.H. Tengan Oxidative phosphorylation dysfunction does not increase the rate of accumulation of age-related mtDNA deletions in skeletal muscle Mutat. Res. 379 1997 1 11
    • (1997) Mutat. Res. , vol.379 , pp. 1-11
    • Tengan, C.H.1
  • 86
    • 29744435923 scopus 로고    scopus 로고
    • Cells discover fire: Employing reactive oxygen species in development and consequences for aging
    • de
    • de J.P. Magalhaes, and G.M. Church Cells discover fire: employing reactive oxygen species in development and consequences for aging Exp. Gerontol. 41 2006 1 10
    • (2006) Exp. Gerontol. , vol.41 , pp. 1-10
    • Magalhaes, J.P.1    Church, G.M.2
  • 87
    • 2642580016 scopus 로고    scopus 로고
    • Premature ageing in mice expressing defective mitochondrial DNA polymerase
    • A. Trifunovic Premature ageing in mice expressing defective mitochondrial DNA polymerase Nature 429 2004 417 423
    • (2004) Nature , vol.429 , pp. 417-423
    • Trifunovic, A.1
  • 88
    • 0034667349 scopus 로고    scopus 로고
    • Construction of transgenic mice with tissue-specific acceleration of mitochondrial DNA mutagenesis
    • D. Zhang Construction of transgenic mice with tissue-specific acceleration of mitochondrial DNA mutagenesis Genomics 69 2000 151 161
    • (2000) Genomics , vol.69 , pp. 151-161
    • Zhang, D.1
  • 89
    • 0035283326 scopus 로고    scopus 로고
    • Oxidative stress is not an obligate mediator of disease provoked by mitochondrial DNA mutations
    • J.L. Mott Oxidative stress is not an obligate mediator of disease provoked by mitochondrial DNA mutations Mutat. Res. 474 2001 35 45
    • (2001) Mutat. Res. , vol.474 , pp. 35-45
    • Mott, J.L.1
  • 90
    • 33751525408 scopus 로고    scopus 로고
    • Oxidative stress, mitochondria and mtDNA-mutator mice
    • L.V. Thompson Oxidative stress, mitochondria and mtDNA-mutator mice Exp. Gerontol. 41 2006 1220 1222
    • (2006) Exp. Gerontol. , vol.41 , pp. 1220-1222
    • Thompson, L.V.1
  • 91
    • 84904988972 scopus 로고    scopus 로고
    • In vivo levels of mitochondrial hydrogen peroxide increase with age in mtDNA mutator mice
    • A. Logan In vivo levels of mitochondrial hydrogen peroxide increase with age in mtDNA mutator mice Aging Cell 13 2014 765 768
    • (2014) Aging Cell , vol.13 , pp. 765-768
    • Logan, A.1
  • 92
    • 62849099539 scopus 로고    scopus 로고
    • Analysis of the clonal architecture of the human small intestinal epithelium establishes a common stem cell for all lineages and reveals a mechanism for the fixation and spread of mutations
    • L. Gutierrez-Gonzalez Analysis of the clonal architecture of the human small intestinal epithelium establishes a common stem cell for all lineages and reveals a mechanism for the fixation and spread of mutations J. Pathol. 217 2009 489 496
    • (2009) J. Pathol. , vol.217 , pp. 489-496
    • Gutierrez-Gonzalez, L.1
  • 93
    • 0024366601 scopus 로고
    • Cytochrome-c-oxidase deficient cardiomyocytes in the human heart - An age-related phenomenon. A histochemical ultracytochemical study
    • J. Muller-Hocker Cytochrome-c-oxidase deficient cardiomyocytes in the human heart - an age-related phenomenon. A histochemical ultracytochemical study Am. J. Pathol. 134 1989 1167 1173
    • (1989) Am. J. Pathol. , vol.134 , pp. 1167-1173
    • Muller-Hocker, J.1
  • 94
    • 0025673968 scopus 로고
    • Cytochrome c oxidase deficient fibres in the limb muscle and diaphragm of man without muscular disease: An age-related alteration
    • J. Muller-Hocker Cytochrome c oxidase deficient fibres in the limb muscle and diaphragm of man without muscular disease: an age-related alteration J. Neurol. Sci. 100 1990 14 21
    • (1990) J. Neurol. Sci. , vol.100 , pp. 14-21
    • Muller-Hocker, J.1
  • 95
    • 0035943058 scopus 로고    scopus 로고
    • Mitochondrial enzyme-deficient hippocampal neurons and choroidal cells in AD
    • D.A. Cottrell Mitochondrial enzyme-deficient hippocampal neurons and choroidal cells in AD Neurology 57 2001 260 264
    • (2001) Neurology , vol.57 , pp. 260-264
    • Cottrell, D.A.1
  • 96
    • 33646375711 scopus 로고    scopus 로고
    • High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease
    • A. Bender High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease Nat. Genet. 38 2006 515 517
    • (2006) Nat. Genet. , vol.38 , pp. 515-517
    • Bender, A.1
  • 97
    • 84903267268 scopus 로고    scopus 로고
    • Mitochondrial genome changes and neurodegenerative diseases
    • M. Pinto, and C.T. Moraes Mitochondrial genome changes and neurodegenerative diseases Biochim. Biophys. Acta 1842 2014 1198 1207
    • (2014) Biochim. Biophys. Acta , vol.1842 , pp. 1198-1207
    • Pinto, M.1    Moraes, C.T.2
  • 98
    • 66149112853 scopus 로고    scopus 로고
    • Locating the stem cell niche and tracing hepatocyte lineages in human liver
    • T.G. Fellous Locating the stem cell niche and tracing hepatocyte lineages in human liver Hepatology 49 2009 1655 1663
    • (2009) Hepatology , vol.49 , pp. 1655-1663
    • Fellous, T.G.1
  • 99
    • 38649113560 scopus 로고    scopus 로고
    • Mechanisms of field cancerization in the human stomach: The expansion and spread of mutated gastric stem cells
    • S.A. McDonald Mechanisms of field cancerization in the human stomach: the expansion and spread of mutated gastric stem cells Gastroenterology 134 2008 500 510
    • (2008) Gastroenterology , vol.134 , pp. 500-510
    • McDonald, S.A.1
  • 100
    • 84884416043 scopus 로고    scopus 로고
    • Germline mitochondrial DNA mutations aggravate ageing and can impair brain development
    • J.M. Ross Germline mitochondrial DNA mutations aggravate ageing and can impair brain development Nature 501 2013 412 415
    • (2013) Nature , vol.501 , pp. 412-415
    • Ross, J.M.1
  • 101
    • 0036236006 scopus 로고    scopus 로고
    • The mitochondrial-lysosomal axis theory of aging: Accumulation of damaged mitochondria as a result of imperfect autophagocytosis
    • U.T. Brunk, and A. Terman The mitochondrial-lysosomal axis theory of aging: accumulation of damaged mitochondria as a result of imperfect autophagocytosis Eur. J. Biochem. 269 2002 1996 2002
    • (2002) Eur. J. Biochem. , vol.269 , pp. 1996-2002
    • Brunk, U.T.1    Terman, A.2
  • 102
    • 0031081410 scopus 로고    scopus 로고
    • A proposed refinement of the mitochondrial free radical theory of aging
    • A.D. de Grey A proposed refinement of the mitochondrial free radical theory of aging Bioessays 19 1997 161 166
    • (1997) Bioessays , vol.19 , pp. 161-166
    • De Grey, A.D.1
  • 103
    • 0036848145 scopus 로고    scopus 로고
    • Human mitochondrial DNA with large deletions repopulates organelles faster than full-length genomes under relaxed copy number control
    • F. Diaz Human mitochondrial DNA with large deletions repopulates organelles faster than full-length genomes under relaxed copy number control Nucleic Acids Res. 30 2002 4626 4633
    • (2002) Nucleic Acids Res. , vol.30 , pp. 4626-4633
    • Diaz, F.1
  • 104
    • 0026457825 scopus 로고
    • Marked replicative advantage of human mtDNA carrying a point mutation that causes the MELAS encephalomyopathy
    • M. Yoneda Marked replicative advantage of human mtDNA carrying a point mutation that causes the MELAS encephalomyopathy Proc. Natl. Acad. Sci. USA 89 1992 11164 11168
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 11164-11168
    • Yoneda, M.1
  • 105
    • 0033968516 scopus 로고    scopus 로고
    • The reductive hotspot hypothesis: An update
    • A.D. de Grey The reductive hotspot hypothesis: an update Arch. Biochem. Biophys. 373 2000 295 301
    • (2000) Arch. Biochem. Biophys. , vol.373 , pp. 295-301
    • De Grey, A.D.1
  • 106
    • 29744435923 scopus 로고    scopus 로고
    • Cells discover fire: Employing reactive oxygen species in development and consequences for aging
    • J.P. de Magalhaes, and G. Church Cells discover fire: employing reactive oxygen species in development and consequences for aging Exp. Gerontol. 41 2006 1 10
    • (2006) Exp. Gerontol. , vol.41 , pp. 1-10
    • De Magalhaes, J.P.1    Church, G.2
  • 107
    • 1242293164 scopus 로고    scopus 로고
    • Energy restriction controls aging through neuroendocrine signal transduction
    • Y.N. Berner, and F. Stern Energy restriction controls aging through neuroendocrine signal transduction Ageing Res. Rev. 3 2004 189 198
    • (2004) Ageing Res. Rev. , vol.3 , pp. 189-198
    • Berner, Y.N.1    Stern, F.2
  • 108
    • 0642276003 scopus 로고    scopus 로고
    • Redox regulation of protein tyrosine phosphatases during receptor tyrosine kinase signal transduction
    • P. Chiarugi, and P. Cirri Redox regulation of protein tyrosine phosphatases during receptor tyrosine kinase signal transduction Trends Biochem. Sci. 28 2003 509 514
    • (2003) Trends Biochem. Sci. , vol.28 , pp. 509-514
    • Chiarugi, P.1    Cirri, P.2
  • 109
    • 0033963704 scopus 로고    scopus 로고
    • Oxidative stress and gene regulation
    • R.G. Allen, and M. Tresini Oxidative stress and gene regulation Free Radic. Biol. Med. 28 2000 463 499
    • (2000) Free Radic. Biol. Med. , vol.28 , pp. 463-499
    • Allen, R.G.1    Tresini, M.2
  • 110
    • 0036478970 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species in cell death signaling
    • 41
    • C. Fleury, B. Mignotte, and J.L. Vayssiere Mitochondrial reactive oxygen species in cell death signaling Biochimie 84 2002 131 -41
    • (2002) Biochimie , vol.84 , pp. 131
    • Fleury, C.1    Mignotte, B.2    Vayssiere, J.L.3
  • 111
    • 0033583242 scopus 로고    scopus 로고
    • Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species
    • A.C. Lee Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species J. Biol. Chem. 274 1999 7936 7940
    • (1999) J. Biol. Chem. , vol.274 , pp. 7936-7940
    • Lee, A.C.1
  • 112
    • 0036566326 scopus 로고    scopus 로고
    • Inhibition of p21-mediated ROS accumulation can rescue p21-induced senescence
    • S. Macip Inhibition of p21-mediated ROS accumulation can rescue p21-induced senescence EMBO J. 21 2002 2180 2188
    • (2002) EMBO J. , vol.21 , pp. 2180-2188
    • Macip, S.1
  • 113
    • 0242552555 scopus 로고    scopus 로고
    • Influence of induced reactive oxygen species in p53-mediated cell fate decisions
    • S. Macip Influence of induced reactive oxygen species in p53-mediated cell fate decisions Mol. Cell. Biol. 23 2003 8576 8585
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 8576-8585
    • Macip, S.1
  • 114
    • 0036260697 scopus 로고    scopus 로고
    • Cellular response to oxidative stress: Signaling for suicide and survival
    • J.L. Martindale, and N.J. Holbrook Cellular response to oxidative stress: signaling for suicide and survival J. Cell. Physiol. 192 2002 1 15
    • (2002) J. Cell. Physiol. , vol.192 , pp. 1-15
    • Martindale, J.L.1    Holbrook, N.J.2
  • 115
    • 84868007565 scopus 로고    scopus 로고
    • Physiological roles of mitochondrial reactive oxygen species
    • L.A. Sena, and N.S. Chandel Physiological roles of mitochondrial reactive oxygen species Mol. Cell 48 2012 158 167
    • (2012) Mol. Cell , vol.48 , pp. 158-167
    • Sena, L.A.1    Chandel, N.S.2
  • 116
    • 84900299463 scopus 로고    scopus 로고
    • The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C. Elegans
    • C. Yee, W. Yang, and S. Hekimi The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C. elegans Cell 157 2014 897 909
    • (2014) Cell , vol.157 , pp. 897-909
    • Yee, C.1    Yang, W.2    Hekimi, S.3
  • 117
    • 54449091329 scopus 로고    scopus 로고
    • Early mitochondrial dysfunction in long-lived Mclk1+/- mice
    • 2627
    • J. Lapointe, and S. Hekimi Early mitochondrial dysfunction in long-lived Mclk1+/- mice J. Biol. Chem. 283 2008 26217 -2627
    • (2008) J. Biol. Chem. , vol.283 , pp. 26217
    • Lapointe, J.1    Hekimi, S.2
  • 118
    • 78650455712 scopus 로고    scopus 로고
    • A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans
    • W. Yang, and S. Hekimi A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans PLoS Biol. 8 2010 e1000556
    • (2010) PLoS Biol. , vol.8 , pp. e1000556
    • Yang, W.1    Hekimi, S.2
  • 120
    • 84856284594 scopus 로고    scopus 로고
    • Mechanisms of mitochondrial diseases
    • E. Ylikallio, and A. Suomalainen Mechanisms of mitochondrial diseases Ann. Med. 44 2012 41 59
    • (2012) Ann. Med. , vol.44 , pp. 41-59
    • Ylikallio, E.1    Suomalainen, A.2
  • 121
    • 0035097502 scopus 로고    scopus 로고
    • Random intracellular drift explains the clonal expansion of mitochondrial DNA mutations with age
    • J.L. Elson Random intracellular drift explains the clonal expansion of mitochondrial DNA mutations with age Am. J. Hum. Genet. 68 2001 802 806
    • (2001) Am. J. Hum. Genet. , vol.68 , pp. 802-806
    • Elson, J.L.1
  • 122
    • 34548153747 scopus 로고    scopus 로고
    • How stem cells age and why this makes us grow old
    • N.E. Sharpless, and R.A. DePinho How stem cells age and why this makes us grow old Nat. Rev. Mol. Cell Biol. 8 2007 703 713
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 703-713
    • Sharpless, N.E.1    Depinho, R.A.2
  • 123
    • 84895788635 scopus 로고    scopus 로고
    • Human stem cell aging: Do mitochondrial DNA mutations have a causal role?
    • H.L. Baines, D.M. Turnbull, and L.C. Greaves Human stem cell aging: do mitochondrial DNA mutations have a causal role? Aging Cell 13 2014 201 205
    • (2014) Aging Cell , vol.13 , pp. 201-205
    • Baines, H.L.1    Turnbull, D.M.2    Greaves, L.C.3
  • 124
    • 76249101972 scopus 로고    scopus 로고
    • Age-associated mitochondrial DNA mutations lead to small but significant changes in cell proliferation and apoptosis in human colonic crypts
    • M. Nooteboom Age-associated mitochondrial DNA mutations lead to small but significant changes in cell proliferation and apoptosis in human colonic crypts Aging Cell 9 2010 96 99
    • (2010) Aging Cell , vol.9 , pp. 96-99
    • Nooteboom, M.1
  • 125
    • 84855417557 scopus 로고    scopus 로고
    • Somatic progenitor cell vulnerability to mitochondrial DNA mutagenesis underlies progeroid phenotypes in Polg mutator mice
    • K.J. Ahlqvist Somatic progenitor cell vulnerability to mitochondrial DNA mutagenesis underlies progeroid phenotypes in Polg mutator mice Cell Metab. 15 2012 100 109
    • (2012) Cell Metab. , vol.15 , pp. 100-109
    • Ahlqvist, K.J.1
  • 126
    • 79955698235 scopus 로고    scopus 로고
    • Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging
    • G.L. Norddahl Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging Cell Stem Cell 8 2011 499 510
    • (2011) Cell Stem Cell , vol.8 , pp. 499-510
    • Norddahl, G.L.1
  • 127
    • 84885183399 scopus 로고    scopus 로고
    • Transient systemic mtDNA damage leads to muscle wasting by reducing the satellite cell pool
    • X. Wang Transient systemic mtDNA damage leads to muscle wasting by reducing the satellite cell pool Hum. Mol. Genet. 22 2013 3976 3986
    • (2013) Hum. Mol. Genet. , vol.22 , pp. 3976-3986
    • Wang, X.1
  • 128
    • 84905921360 scopus 로고    scopus 로고
    • Glucose and glutamine metabolism regulate human hematopoietic stem cell lineage specification
    • L. Oburoglu Glucose and glutamine metabolism regulate human hematopoietic stem cell lineage specification Cell Stem Cell 15 2014 169 184
    • (2014) Cell Stem Cell , vol.15 , pp. 169-184
    • Oburoglu, L.1
  • 129
    • 84904288038 scopus 로고    scopus 로고
    • Cross talk between cellular redox status, metabolism, and p53 in neural stem cell biology
    • K. Forsberg, and S. Di Giovanni Cross talk between cellular redox status, metabolism, and p53 in neural stem cell biology Neuroscientist 20 2014 326 342
    • (2014) Neuroscientist , vol.20 , pp. 326-342
    • Forsberg, K.1    Di Giovanni, S.2
  • 130
    • 77955273858 scopus 로고    scopus 로고
    • Mitochondrial respiration defects modulate differentiation but not proliferation of hematopoietic stem and progenitor cells
    • S. Inoue Mitochondrial respiration defects modulate differentiation but not proliferation of hematopoietic stem and progenitor cells FEBS Lett. 584 2010 3402 3409
    • (2010) FEBS Lett. , vol.584 , pp. 3402-3409
    • Inoue, S.1
  • 131
    • 77956205122 scopus 로고    scopus 로고
    • The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche
    • T. Simsek The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche Cell Stem Cell 7 2010 380 390
    • (2010) Cell Stem Cell , vol.7 , pp. 380-390
    • Simsek, T.1
  • 132
    • 79960077503 scopus 로고    scopus 로고
    • Reactive oxygen species and hematopoietic stem cell senescence
    • L. Shao Reactive oxygen species and hematopoietic stem cell senescence Int. J. Hematol. 94 2011 24 32
    • (2011) Int. J. Hematol. , vol.94 , pp. 24-32
    • Shao, L.1
  • 133
    • 0036236939 scopus 로고    scopus 로고
    • The reductive hotspot hypothesis of mammalian aging: Membrane metabolism magnifies mutant mitochondrial mischief
    • de
    • de A.D. Grey The reductive hotspot hypothesis of mammalian aging: membrane metabolism magnifies mutant mitochondrial mischief Eur. J. Biochem. 269 2002 2003 2009
    • (2002) Eur. J. Biochem. , vol.269 , pp. 2003-2009
    • Grey, A.D.1
  • 134
    • 84882722311 scopus 로고    scopus 로고
    • The free radical theory of aging revisited: The cell signaling disruption theory of aging
    • J. Vina The free radical theory of aging revisited: the cell signaling disruption theory of aging Antioxid. Redox Signaling 19 2013 779 787
    • (2013) Antioxid. Redox Signaling , vol.19 , pp. 779-787
    • Vina, J.1
  • 135
    • 0029864498 scopus 로고    scopus 로고
    • Human brain contains high levels of heteroplasmy in the noncoding regions of mitochondrial DNA
    • E.E. Jazin Human brain contains high levels of heteroplasmy in the noncoding regions of mitochondrial DNA Proc. Natl. Acad. Sci. USA 93 1996 12382 12387
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 12382-12387
    • Jazin, E.E.1
  • 136
    • 0029741431 scopus 로고    scopus 로고
    • Evidence that specific mtDNA point mutations may not accumulate in skeletal muscle during normal human aging
    • F. Pallotti Evidence that specific mtDNA point mutations may not accumulate in skeletal muscle during normal human aging Am. J. Hum. Genet. 59 1996 591 602
    • (1996) Am. J. Hum. Genet. , vol.59 , pp. 591-602
    • Pallotti, F.1
  • 137
    • 0032030309 scopus 로고    scopus 로고
    • Mutations in mitochondrial DNA accumulate differentially in three different human tissues during ageing
    • V.W. Liu, C. Zhang, and P. Nagley Mutations in mitochondrial DNA accumulate differentially in three different human tissues during ageing Nucleic Acids Res. 26 1998 1268 1275
    • (1998) Nucleic Acids Res. , vol.26 , pp. 1268-1275
    • Liu, V.W.1    Zhang, C.2    Nagley, P.3
  • 138
    • 0035957323 scopus 로고    scopus 로고
    • Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication
    • Y. Wang Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication Proc. Natl. Acad. Sci. USA 98 2001 4022 4027
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 4022-4027
    • Wang, Y.1
  • 139
    • 0037110426 scopus 로고    scopus 로고
    • Evidence and age-related distribution of mtDNA D-loop point mutations in skeletal muscle from healthy subjects and mitochondrial patients
    • R. Del Bo Evidence and age-related distribution of mtDNA D-loop point mutations in skeletal muscle from healthy subjects and mitochondrial patients J. Neurol. Sci. 202 2002 85 91
    • (2002) J. Neurol. Sci. , vol.202 , pp. 85-91
    • Del Bo, R.1
  • 140
    • 0037081814 scopus 로고    scopus 로고
    • High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain
    • M.T. Lin High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain Hum. Mol. Genet. 11 2002 133 145
    • (2002) Hum. Mol. Genet. , vol.11 , pp. 133-145
    • Lin, M.T.1
  • 141
    • 0036132121 scopus 로고    scopus 로고
    • Mitochondrial DNA mutation analysis in human skin fibroblasts from fetal, young, and old donors
    • G.S. Gerhard Mitochondrial DNA mutation analysis in human skin fibroblasts from fetal, young, and old donors Mech. Ageing Dev. 123 2002 155 166
    • (2002) Mech. Ageing Dev. , vol.123 , pp. 155-166
    • Gerhard, G.S.1
  • 142
    • 0037117576 scopus 로고    scopus 로고
    • Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues
    • E. Nekhaeva Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues Proc. Natl. Acad. Sci. USA 99 2002 5521 5526
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 5521-5526
    • Nekhaeva, E.1
  • 143
    • 18244362585 scopus 로고    scopus 로고
    • Mitochondrial DNA damage in lymphocytes: A role in immunosenescence? Exp
    • O.A. Ross Mitochondrial DNA damage in lymphocytes: a role in immunosenescence? Exp Gerontol 37 2002 329 340
    • (2002) Gerontol , vol.37 , pp. 329-340
    • Ross, O.A.1
  • 144
    • 10744231633 scopus 로고    scopus 로고
    • Somatic mitochondrial DNA mutations in cortex and substantia nigra in aging and Parkinson's disease
    • D.K. Simon Somatic mitochondrial DNA mutations in cortex and substantia nigra in aging and Parkinson's disease Neurobiol. Aging 25 2004 71 81
    • (2004) Neurobiol. Aging , vol.25 , pp. 71-81
    • Simon, D.K.1
  • 145
    • 33745738122 scopus 로고    scopus 로고
    • Detection and quantification of the age-related point mutation A189G in the human mitochondrial DNA
    • C. Theves Detection and quantification of the age-related point mutation A189G in the human mitochondrial DNA J. Forensic Sci. 51 2006 865 873
    • (2006) J. Forensic Sci. , vol.51 , pp. 865-873
    • Theves, C.1
  • 146
    • 67651166799 scopus 로고    scopus 로고
    • The low abundance of clonally expanded mitochondrial DNA point mutations in aged substantia nigra neurons
    • A.K. Reeve The low abundance of clonally expanded mitochondrial DNA point mutations in aged substantia nigra neurons Aging Cell 8 2009 496 498
    • (2009) Aging Cell , vol.8 , pp. 496-498
    • Reeve, A.K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.