Targeted delivery of DNA to the mitochondrial compartment via import sequence-conjugated peptide nucleic acid

Molecular Therapy

Volumn 7, Issue 4, 2003, Pages 550-557

  Flierl, A ^a,d   Jackson, C ^b   Cottrell, B ^a,d   Murdock, D ^a,e   Seibel, P ^c   Wallace, D C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Research Genetics   (United States)

^c UNIVERSITY OF WÜRZBURG   (Germany)

^d BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^e VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Drug delivery; Gene therapy; Import; Mitochondria; Oligonucleotide; Peptide nucleic acid; Targeting peptide; Transformation

Indexed keywords

DNA; NUCLEIC ACID; OLIGONUCLEOTIDE; PEPTIDE; POLYCATION; TOXIN;

ANIMAL CELL; ARTICLE; CELL COMPARTMENTALIZATION; CELL CULTURE; COMPLEX FORMATION; CONJUGATION; CONTROLLED STUDY; CYTOSOL; DNA MODIFICATION; GENE DELIVERY SYSTEM; GENE TARGETING; MAMMAL CELL; MITOCHONDRIAL GENETICS; MITOCHONDRIAL MEMBRANE; NONHUMAN; NUCLEAR IMPORT; NUCLEOTIDE SEQUENCE; OUTER MEMBRANE;

ANIMALIA; MAMMALIA;

EID: 0038365420     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1525-0016(03)00037-6     Document Type: Article

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