DQAsome-mediated delivery of plasmid DNA toward mitochondria in living cells

Journal of Controlled Release

Volumn 92, Issue 1-2, 2003, Pages 189-197

  D'Souza, Gerard G M ^a   Rammohan, Ram ^a   Cheng, Shing Ming ^a   Torchilin, Vladimir P ^a   Weissig, Volkmar ^a  

^a NORTHEASTERN UNIVERSITY   (United States)

Author keywords

Dequalinium; DNA delivery; DQAsomes; Gene therapy; Mitochondria; Mitochondrial targeting

Indexed keywords

BIOLOGICAL MEMBRANES; DNA; GENETIC ENGINEERING;

CONFOCAL FLUORESCENCE MICROSCOPY;

CELL CULTURE;

DEQUALINIUM; LIPOSOME; PLASMID DNA;

ANIMAL CELL; ARTICLE; CYTOSOL; ENDOSOME; ERYTHROCYTE; FLUORESCENCE MICROSCOPY; GENE TARGETING; GENE THERAPY; GENETIC TRANSFECTION; LIPID VESICLE; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0141763942     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(03)00297-9     Document Type: Article

References (18)

1. Bernal S.D., Lampidis T.J., McIsaac R.M., Chen L.B. Anticarcinoma activity in vivo of rhodamine 123, a mitochondrial-specific dye. Science. 222:1983;169-172.
2. Chrzanowska-Lightowlers Z.M., Lightowlers R.N., Turnbull D.M. Gene therapy for mitochondrial DNA defects: is it possible? Gene Ther. 2:1995;311-316.
3. El Ouahabi A., Thiry M., Pector V., Fuks R., Ruysschaert J.M., Vandenbranden M. The role of endosome destabilizing activity in the gene transfer process mediated by cationic lipids. FEBS Lett. 414:1997;187-192.
4. Holt I.J., Harding A.E., Morgan-Hughes J.A. Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies. Nature. 331:1988;717-719.
5. Lasch J., Meye A., Taubert H., Koelsch R., Mansa-ard J., Weissig V. Dequalinium vesicles form stable complexes with plasmid DNA which are protected from DNase attack. Biol Chem. 380:1999;647-652.
6. Lasch J., Weissig V., Brandl M. Preparation of liposomes. Torchilin V.P., Weissig V. Liposomes - a Practical Approach. 2003;3-30 Oxford University Press, Oxford.
7. Modica-Napolitano J.S., Aprille J.R. Delocalized lipophilic cations selectively target the mitochondria of carcinoma cells. Adv Drug Deliv Rev. 49:2001;63-70.
8. Pulkes T., Hanna M.G. Human mitochondrial DNA diseases. Adv Drug Deliv Rev. 49:2001;27-43.
9. van der Woude I., Wagenaar A., Meekel A.A., ter Beest M.B., Ruiters M.H., Engberts J.B., Hoekstra D. Novel pyridinium surfactants for efficient, nontoxic in vitro gene delivery. Proc Natl Acad Sci USA. 94:1997;1160-1165.
10. Wallace D.C., Singh G., Lott M.T., Hodge J.A., Schurr T.G., Lezza A.M., Elsas L.J. 2nd, Nikoskelainen E.K. Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy. Science. 242:1988;1427-1430.
11. Wattiaux R., Jadot M., Warnier-Pirotte M.T., Wattiaux-De Coninck S. Cationic lipids destabilize lysosomal membrane in vitro. FEBS Lett. 417:1997;199-202.
12. Weissig V., D'Souza G.G., Torchilin V.P. DQAsome-DNA complexes release DNA upon contact with isolated mouse liver mitochondria. J Control Release. 75:2001;401-408.
13. Weissig V., Lasch J., Erdos G., Meyer H.W., Rowe T.C., Hughes J. DQAsomes: a novel potential drug and gene delivery system made from Dequalinium. Pharm Res. 15:1998;334-337.
14. Weissig V., Lizano C., Torchilin V.P. Selective DNA release from DQAsome-DNA complexes at mitochondria-like membranes. Drug Deliv. 7:2000;1-5.
15. Weissig V., Torchilin V.P. Cationic bolasomes with delocalized charge centers as mitochondria-specific DNA delivery systems. Adv Drug Deliv Rev. 49:2001;127-149.
16. Weissig V., Torchilin V.P. Towards mitochondrial gene therapy: DQAsomes as a strategy. J Drug Target. 9:2001;1-13.
17. Xu Y., Szoka F.C. Jr. Mechanism of DNA release from cationic liposome/ DNA complexes used in cell transfection. Biochemistry. 35:1996;5616-5623.
18. Zuhorn I.S., Hoekstra D. On the mechanism of cationic amphiphile-mediated transfection. To fuse or not to fuse: is that the question? J Membr Biol. 189:2002;167-179.