Mitochondrial matrix delivery using MITO-Porter, a liposome-based carrier that specifies fusion with mitochondrial membranes

Biochemical and Biophysical Research Communications

Volumn 397, Issue 2, 2010, Pages 181-186

  Yasuzaki, Yukari ^a   Yamada, Yuma ^a   Harashima, Hideyoshi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Membrane fusion; MITO Porter; Mitochondria; Mitochondrial drug delivery; Mitochondrial gene therapy; Mitochondrial matrix delivery; mtDNA

Indexed keywords

FLUORESCENT DYE; MITOCHONDRIAL DNA; NUCLEIC ACID; PROPIDIUM IODIDE; LIPOSOME;

ANIMAL CELL; ARTICLE; CARCINOMA CELL; CONFOCAL LASER MICROSCOPY; DRUG DELIVERY SYSTEM; FLUORESCENCE; HELA CELL; HUMAN; HUMAN CELL; LIVER MITOCHONDRION; MACROMOLECULE; MEMBRANE FUSION; MITO PORTER; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; CHEMISTRY; CONFOCAL MICROSCOPY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; GENE THERAPY; GENETIC TRANSDUCTION; METABOLISM; WISTAR RAT;

RATTUS;

ANIMALS; DNA, MITOCHONDRIAL; FLUORESCENT DYES; GENE THERAPY; HELA CELLS; HUMANS; LIPOSOMES; MEMBRANE FUSION; MICROSCOPY, CONFOCAL; MITOCHONDRIA, LIVER; MITOCHONDRIAL DISEASES; MITOCHONDRIAL MEMBRANES; PROPIDIUM; RATS; RATS, WISTAR; TRANSDUCTION, GENETIC;

EID: 77955480347     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.05.070     Document Type: Article

References (23)

1. S. DiMauro, Mitochondrial myopathies, Curr. Opin. Rheumatol. 18 (2006) 636-641.
2. I.J. Holt, A.E. Harding, J.A. Morgan-Hughes, Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies, Nature 331 (1988) 717-719.
3. Y. Kagawa, Y. Inoki, H. Endo, Gene therapy by mitochondrial transfer, Adv. Drug Deliv. Rev. 49 (2001) 107-119.
4. L.J. Martin, Mitochondriopathy in Parkinson disease and amyotrophic lateral sclerosis, J. Neuropathol. Exp. Neurol. 65 (2006) 1103-1110.
5. E. Sarzi, M.D. Brown, S. Lebon, D. Chretien, A. Munnich, A. Rotig, V. Procaccio, A novel recurrent mitochondrial DNA mutation in ND3 gene is associated with isolated complex I deficiency causing Leigh syndrome and dystonia, Am. J. Med. Genet. A 143 (2007) 33-41.
6. D.C. Wallace, Mitochondrial diseases in man and mouse, Science 283 (1999) 1482-1488.
7. D.C. Wallace, The mitochondrial genome in human adaptive radiation and disease: on the road to therapeutics and performance enhancement, Gene 354 (2005) 169-180.
8. Y. Goto, I. Nonaka, S. Horai, A mutation in the tRNA(Leu)(UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathies, Nature 348 (1990) 651-653.
9. J.M. Shoffner, M.T. Lott, A.M. Lezza, P. Seibel, S.W. Ballinger, D.C. Wallace, Myoclonic epilepsy and ragged-red fiber disease (MERRF) is associated with a mitochondrial DNA tRNA(Lys) mutation, Cell 61 (1990) 931-937.
10. S. Shanske, C.T. Moraes, A. Lombes, A.F. Miranda, E. Bonilla, P. Lewis, M.A. Whelan, C.A. Ellsworth, S. DiMauro, Widespread tissue distribution of mitochondrial DNA deletions in Kearns-Sayre syndrome, Neurology 40 (1990) 24-28.
11. A. Flierl, C. Jackson, B. Cottrell, D. Murdock, P. Seibel, D.C. Wallace, Targeted delivery of DNA to the mitochondrial compartment via import sequence-conjugated peptide nucleic acid, Mol. Ther. 7 (2003) 550-557.
12. G. Schatz, The protein import system of mitochondria, J. Biol. Chem. 271 (1996) 31763-31766.
13. T. Endo, Y. Nakayama, M. Nakai, Avidin fusion protein as a tool to generate a stable translocation intermediate spanning the mitochondrial membranes, J. Biochem. (Tokyo) 118 (1995) 753-759.
14. M. Esaki, T. Kanamori, S. Nishikawa, T. Endo, Two distinct mechanisms drive protein translocation across the mitochondrial outer membrane in the late step of the cytochrome b(2) import pathway, Proc. Natl. Acad. Sci. USA 96 (1999) 11770-11775.
15. A. Gruhler, H. Ono, B. Guiard, W. Neupert, R.A. Stuart, A novel intermediate on the import pathway of cytochrome b2 into mitochondria: evidence for conservative sorting, EMBO J. 14 (1995) 1349-1359.
16. Y. Yamada, H. Akita, H. Kamiya, K. Kogure, T. Yamamoto, Y. Shinohara, K. Yamashita, H. Kobayashi, H. Kikuchi, H. Harashima, MITO-Porter: a liposome-based carrier system for delivery of macromolecules into mitochondria via membrane fusion, Biochim. Biophys. Acta 1778 (2008) 423-432.
17. Y. Yamada, H. Akita, K. Kogure, H. Kamiya, H. Harashima, Mitochondrial drug delivery and mitochondrial disease therapy - an approach to liposome-based delivery targeted to mitochondria, Mitochondrion 7 (2007) 63-71.
18. S. Futaki, W. Ohashi, T. Suzuki, M. Niwa, S. Tanaka, K. Ueda, H. Harashima, Y. Sugiura, Stearylated arginine-rich peptides: a new class of transfection systems, Bioconjug. Chem. 12 (2001) 1005-1011.
19. T.K. Palva, E.T. Palva, Rapid isolation of animal mitochondrial DNA by alkaline extraction, FEBS Lett. 192 (1985) 267-270.
20. S. Meeusen, J.M. McCaffery, J. Nunnari, Mitochondrial fusion intermediates revealed in vitro, Science 305 (2004) 1747-1752.
21. L.V. Johnson, M.L. Walsh, L.B. Chen, Localization of mitochondria in living cells with rhodamine123, Proc. Natl. Acad. Sci. USA 77 (1980) 990-994.
22. R.C. Scaduto Jr., L.W. Grotyohann, Measurement of mitochondrial membrane potential using fluorescent rhodamine derivatives, Biophys. J. 76 (1999) 469-477.
23. T. Ozawa, Y. Natori, M. Sato, Y. Umezawa, Imaging dynamics of endogenous mitochondrial RNA in single living cells, Nat. Methods 4 (2007) 413-419.