Dynamic recruitment and activation of ALS-associated TBK1 with its target optineurin are required for efficient mitophagy

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 24, 2016, Pages E3349-E3358

  Moore, Andrew S ^a   Holzbaur, Erika L F ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Amyotrophic lateral sclerosis; Mitophagy; Optineurin; Parkin; TBK1

Indexed keywords

MICROTUBULE ASSOCIATED PROTEIN; MICROTUBULE ASSOCIATED PROTEIN LIGHT CHAIN; OPTINEURIN; PARKIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOTRANSFERASE; PROTEIN AGGREGATE; TANK BINDING KINASE 1; UNCLASSIFIED DRUG; NUCLEAR DOT PROTEIN 52, HUMAN; NUCLEAR PROTEIN; OPTN PROTEIN, HUMAN; PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; PTEN-INDUCED PUTATIVE KINASE; REACTIVE OXYGEN METABOLITE; SIGNAL PEPTIDE; TAX1BP1 PROTEIN, HUMAN; TBK1 PROTEIN, HUMAN; TRANSCRIPTION FACTOR IIIA; TUMOR PROTEIN; UBIQUITIN PROTEIN LIGASE;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; AUTOPHAGOSOME; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; DEGENERATIVE DISEASE; ENZYME ACTIVATION; HELA CELL LINE; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MITOPHAGY; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RESPIRATORY CHAIN; UBIQUITINATION; GENETICS; METABOLISM; MUTATION;

AMYOTROPHIC LATERAL SCLEROSIS; HELA CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MITOCHONDRIA; MITOCHONDRIAL DEGRADATION; MUTATION; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; REACTIVE OXYGEN SPECIES; TRANSCRIPTION FACTOR TFIIIA; UBIQUITIN-PROTEIN LIGASES;

EID: 84974815636     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1523810113     Document Type: Article

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