A novel diagnostic tool reveals mitochondrial pathology in human diseases and aging

Aging

Volumn 5, Issue 3, 2013, Pages 192-208

  Scheibye Knudsen, Morten ^a   Scheibye Alsing, Karsten ^b   Canugovi, Chandrika ^a   Croteau, Deborah L ^a   Bohr, Vilhelm A ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Aging; Bioenergetics; Bioinformatics; Diagnostics; Mitochondria; Progeria

Indexed keywords

EID: 84877675508     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100546     Document Type: Article

References (39)

1. Haas RH, Parikh S, Falk MJ, Saneto RP, Wolf NI, Darin N, and Cohen BH, Mitochondrial disease: a practical approach for primary care physicians. Pediatrics 2007; 120: 1326'1333.
2. Schapira AH, Mitochondrial disease. Lancet 2006; 368: 70'82.
3. Balaban RS, Nemoto S, and Finkel T, Mitochondria, oxidants, and aging. Cell 2005; 120: 483'495.
4. Corral'Debrinski M, Horton T, Lott MT, Shoffner JM, Beal MF, and Wallace DC, Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age. Nat. Genet. 1992; 2: 324'329.
5. Hudson EK, Hogue BA, Souza'Pinto NC, Croteau DL, Anson RM, Bohr VA, and Hansford RG, Age'associated change in mitochondrial DNA damage. Free Radical Research 1998; 29: 573'579.
6. Schriner SE, Linford NJ, Martin GM, Treuting P, Ogburn CE, Emond M, Coskun PE, Ladiges W, Wolf N, Van RH, Wallace DC, and Rabinovitch PS, Extension of murine life span by overexpression of catalase targeted to mitochondria. Science 2005; 308: 1909'1911.
7. Trifunovic A, Wredenberg A, Falkenberg M, Spelbrink JN, Rovio AT, Bruder CE, Bohlooly Y, Gidlof S, Oldfors A, Wibom R, Tornell J, Jacobs HT, and Larsson NG, Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 2004; 429: 417'423.
8. Petersen KF, Befroy D, Dufour S, Dziura J, Ariyan C, Rothman DL, DiPietro L, Cline GW, and Shulman GI, Mitochondrial dysfunction in the elderly: possible role in insulin resistance. Science 2003; 300: 1140'1142.
9. Someya S, Yu W, Hallows WC, Xu J, Vann JM, Leeuwenburgh C, Tanokura M, Denu JM, and Prolla TA, Sirt3 mediates reduction of oxidative damage and prevention of age'related hearing loss under caloric restriction. Cell 2010; 143: 802'812.
10. Lin MT and Beal MF, Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 2006; 443: 787' 795.
11. Mercer JR, Cheng KK, Figg N, Gorenne I, Mahmoudi M, Griffin J, Vidal'Puig A, Logan A, Murphy MP, and Bennett M, DNA damage links mitochondrial dysfunction to atherosclerosis and the metabolic syndrome. Circ Res 2010; 107: 1021'1031.
12. Lowell BB and Shulman GI, Mitochondrial dysfunction and type 2 diabetes. Science 2005; 307: 384'387.
13. Martin GM and Oshima J, Lessons from human progeroid syndromes. Nature 2000; 408: 263'266.
14. Scheibye'Knudsen M, Ramamoorthy M, Sykora P, Maynard S, Lin P, K.Minor R, M.Wilson III D, Cooper M, Spencer R, de Cabo R, L.Croteau D, A.Bohr, and V Cockayne, syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy. J. Exp. Med. 2012
15. Das BB, Dexheimer TS, Maddali K, and Pommier Y, Role of tyrosyl'DNA phosphodiesterase (TDP1) in mitochondria. Proc. Natl. Acad. Sci. U. S. A 2010; 107: 19790'19795.
16. Sykora P, Croteau DL, Bohr VA, and Wilson DM, III Aprataxin localizes to mitochondria and preserves mitochondrial function. Proc. Natl. Acad. Sci. U. S A 2011; 108: 7437'7442.
17. Valentin'Vega YA, Maclean KH, Tait'Mulder J, Milasta S, Steeves M, Dorsey FC, Cleveland JL, Green DR, and Kastan MB, Mitochondrial dysfunction in ataxia'telangiectasia. Blood 2012; 119: 1490'1500.
18. de Hoon MJ, Imoto S, Nolan J, and Miyano S, Open source clustering software. Bioinformatics. 2004; 20: 1453'1454.
19. Holten D, Hierarchical edge bundles: visualization of adjacency relations in hierarchical data. IEEE Trans. Vis. Comput. Graph. 2006; 12: 741'748.
20. Aamann MD, Sorensen MM, Hvitby C, Berquist BR, Muftuoglu M, Tian J, de Souza'Pinto NC, Scheibye'Knudsen M, Wilson Iii DM, Stevnsner T, and Bohr VA, Cockayne syndrome group B protein promotes mitochondrial DNA stability by supporting the DNA repair association with the mitochondrial membrane. FASEB J. 2010
21. Beghi E and Monticelli ML, Chronic symmetric symptomatic polyneuropathy in the elderly: a field screening investigation of risk factors for polyneuropathy in two Italian communities. Italian General Practitioner Study Group (IGPST). J. Clin. Epidemiol. 1998; 51: 697'702.
22. Guralnik JM, Eisenstaedt RS, Ferrucci L, Klein HG, and Woodman RC, Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia. Blood 2004; 104: 2263'2268.
23. Haavisto M, Geiger U, Mattila K, and Rajala S, A health survey of the very aged in Tampere, Finland. Age Ageing 1984; 13: 266' 272.
24. Hayat MJ, Howlader N, Reichman ME, and Edwards BK, Cancer statistics, trends, and multiple primary cancer analyses from the Surveillance, Epidemiology, and End Results (SEER) Program. Oncologist. 2007; 12: 20'37.
25. Ito M, Hatazawa J, Yamaura H, and Matsuzawa T. Age'related brain atrophy and mental deterioration''a study with computed tomography. Br. J. Radiol. 1981; 54: 384'390.
26. Koller WC, Glatt SL, Fox JH, Kaszniak AW, Wilson RS, and Huckman MS. Cerebellar atrophy: relationship to aging and cerebral atrophy. Neurology 1981; 31: 1486'1488.
27. Melov S, Tarnopolsky MA, Beckman K, Felkey K, and Hubbard A. Resistance exercise reverses aging in human skeletal muscle. PLoS. One. 2007; 2: e465.
28. Naughton C, Bennett K, and Feely J. Prevalence of chronic disease in the elderly based on a national pharmacy claims database. Age Ageing 2006; 35: 633'636.
29. Schnohr P, Lange P, Nyboe J, Appleyard M, and Jensen G. Gray hair, baldness, and wrinkles in relation to myocardial infarction: the Copenhagen City Heart Study. Am. Heart J. 1995; 130: 1003'1010.
30. Tenenhouse A, Joseph L, Kreiger N, Poliquin S, Murray TM, Blondeau L, Berger C, Hanley DA, and Prior JC, Estimation of the prevalence of low bone density in Canadian women and men using a population'specific DXA reference standard: the Canadian Multicentre Osteoporosis Study (CaMos). Osteoporos. Int. 2000; 11: 897'904.
31. Matsuda N, Sato S, Shiba K, Okatsu K, Saisho K, Gautier CA, Sou YS, Saiki S, Kawajiri S, Sato F, Kimura M, Komatsu M, Hattori N, and Tanaka K, PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy. J. Cell Biol. 2010; 189: 211' 221.
32. Martinez'Vicente M, Talloczy Z, Wong E, Tang G, Koga H, Kaushik S, de VR, Arias E, Harris S, Sulzer D, and Cuervo AM, Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease. Nat. Neurosci. 2010; 13: 567'576.
33. Gelfand JM, Duncan JL, Racine CA, Gillum LA, Chin CT, Zhang Y, Zhang Q, Wong LJ, Roorda A, and Green AJ, Heterogeneous patterns of tissue injury in NARP syndrome. J. Neurol. 2011; 258: 440'448.
34. Lee HF, Tsai CR, Chi CS, Lee HJ, and Chen CC, Leigh syndrome: clinical and neuroimaging follow'up. Pediatr. Neurol. 2009; 40: 88'93.
35. Bernstein KA and Rothstein R, At loose ends: resecting a double'strand break. Cell 2009; 137: 807'810.
36. Chu WK and Hickson ID, RecQ helicases: multifunctional genome caretakers. Nat. Rev. Cancer 2009; 9: 644'654.
37. Collado M, Blasco MA, and Serrano M, Cellular senescence in cancer and aging. Cell 2007; 130: 223'233.
38. McFarland R, Taylor RW, and Turnbull DM, The neurology of mitochondrial DNA disease. Lancet Neurol. 2002; 1: 343'351.
39. Hastie,T., Tibshirani,R., & Friedman,J. The Elements of Statistical Learning (Springer,2009).