-
1
-
-
0034681163
-
Acceleration of oligomerization, not fibrillization, is a shared property of both α-synuclein mutations linked to early-onset Parkinson’s disease
-
Conway, K.A.; Lee, S.; Rochet, J.; Ding, T.T.; Williamson, R.E.; Lansbury, P.T. Acceleration of oligomerization, not fibrillization, is a shared property of both α-synuclein mutations linked to early-onset Parkinson’s disease: Implications for pathogenesis and therapy. PNAS 2000, 97, 571–576.
-
(2000)
Implications for Pathogenesis and Therapy. PNAS
, vol.97
, pp. 571-576
-
-
Conway, K.A.1
Lee, S.2
Rochet, J.3
Ding, T.T.4
Williamson, R.E.5
Lansbury, P.T.6
-
2
-
-
0242668337
-
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
-
Kayed, R.; Head, E.; Thompson, J.L.; Mcintire, T.M.; Milton, S.C.; Cotman, C.W.; Glabe, C.G. Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science 2003, 300, 486–489.
-
(2003)
Science
, vol.300
, pp. 486-489
-
-
Kayed, R.1
Head, E.2
Thompson, J.L.3
McIntire, T.M.4
Milton, S.C.5
Cotman, C.W.6
Glabe, C.G.7
-
3
-
-
0030882856
-
α-Synuclein in Lewy bodies
-
Spillantini, M.G.; Schmidt, M.L.; Lee, V.M.-Y.; Trojanowski, J.Q. α-Synuclein in Lewy bodies. Nature 1997, 388, 839–840.
-
(1997)
Nature
, vol.388
, pp. 839-840
-
-
Spillantini, M.G.1
Schmidt, M.L.2
Lee, V.M.3
Trojanowski, J.Q.4
-
4
-
-
84883174947
-
Parkinson’s disease dementia: Convergence of α-synuclein, tau and amyloid-β pathologies
-
Irwin, D.J.; Lee, V.M.-Y.; Trojanowski, J.Q. Parkinson’s disease dementia: Convergence of α-synuclein, tau and amyloid-β pathologies. Nat. Rev. Neurosci. 2013, 14, 626–636.
-
(2013)
Nat. Rev. Neurosci
, vol.14
, pp. 626-636
-
-
Irwin, D.J.1
Lee, V.M.2
Trojanowski, J.Q.3
-
5
-
-
84871414210
-
The many faces of α-synuclein: From structure and toxicity to therapeutic target
-
Lashuel, H.A.; Overk, C.R.; Oueslati, A.; Masliah, E. The many faces of α-synuclein: From structure and toxicity to therapeutic target. Nat. Rev. Neurosci. 2013, 14, 38–48.
-
(2013)
Nat. Rev. Neurosci
, vol.14
, pp. 38-48
-
-
Lashuel, H.A.1
Overk, C.R.2
Oueslati, A.3
Masliah, E.4
-
6
-
-
0033919992
-
Lewy bodies in Alzheimer’s disease: A neuropathological review of 145 cases using alpha-synuclein immunohistochemistry
-
Hamilton, R.L. Lewy bodies in Alzheimer’s disease: A neuropathological review of 145 cases using alpha-synuclein immunohistochemistry. Brain Pathol. 2000, 10, 378–384.
-
(2000)
Brain Pathol
, vol.10
, pp. 378-384
-
-
Hamilton, R.L.1
-
7
-
-
0037383760
-
Regional distribution of alpha-synuclein pathology in unimpaired aging and Alzheimer disease
-
Parkkinen, L.; Soininen, H.; Alafuzoff, I. Regional distribution of alpha-synuclein pathology in unimpaired aging and Alzheimer disease. J. Neuropathol. Exp. Neurol. 2003, 62, 363–367.
-
(2003)
J. Neuropathol. Exp. Neurol.
, vol.62
, pp. 363-367
-
-
Parkkinen, L.1
Soininen, H.2
Alafuzoff, I.3
-
8
-
-
7944238570
-
Lewy body-related alpha-synucleinopathy in the aged human brain
-
Jellinger, K.A. Lewy body-related alpha-synucleinopathy in the aged human brain. J. Neural Transm. 2004, 111, 1219–1235.
-
(2004)
J. Neural Transm
, vol.111
, pp. 1219-1235
-
-
Jellinger, K.A.1
-
9
-
-
84864247708
-
Soluble α-synuclein is a novel modulator of Alzheimer’s disease pathophysiology
-
Larson, M.E.; Sherman, M.A.; Greimel, S.; Kuskowski, M.; Schneider, J.A.; Bennett, D.A.; Lesné, S.E. Soluble α-synuclein is a novel modulator of Alzheimer’s disease pathophysiology. J. Neurosci. 2012, 32, 10253–10266.
-
(2012)
J. Neurosci
, vol.32
, pp. 10253-10266
-
-
Larson, M.E.1
Sherman, M.A.2
Greimel, S.3
Kuskowski, M.4
Schneider, J.A.5
Bennett, D.A.6
Lesné, S.E.7
-
10
-
-
4644290985
-
α-Synuclein locus duplication as a cause of familial Parkinson’s disease
-
Chartier-Harlin, M.; Kachergus, J.; Roumier, C.; Mouroux, V.; Douay, X.; Lincoln, S.; Levecque, C.; Larvor, L.; Andrieux, J.; Hulihan, M; et al. α-Synuclein locus duplication as a cause of familial Parkinson’s disease. Lancet 2004, 364, 1167–1169.
-
(2004)
Lancet
, vol.364
, pp. 1167-1169
-
-
Chartier-Harlin, M.1
Kachergus, J.2
Roumier, C.3
Mouroux, V.4
Douay, X.5
Lincoln, S.6
Levecque, C.7
Larvor, L.8
Andrieux, J.9
Hulihan, M.10
-
11
-
-
37849012348
-
α-Synuclein gene duplication is present in sporadic Parkinson disease
-
Ahn, T.B.; Kim, S.Y.; Kim, J.Y.; Park, S.S.; Lee, D.S.; Min, H.J.; Kim, Y.K.; Kim, S.E.; Kim, J.M.; Kim, H.J; et al. α-Synuclein gene duplication is present in sporadic Parkinson disease. Neurology 2008, 70, 43–49.
-
(2008)
Neurology
, vol.70
, pp. 43-49
-
-
Ahn, T.B.1
Kim, S.Y.2
Kim, J.Y.3
Park, S.S.4
Lee, D.S.5
Min, H.J.6
Kim, Y.K.7
Kim, S.E.8
Kim, J.M.9
Kim, H.J.10
-
12
-
-
84879601960
-
The many faces of alpha-synuclein mutations
-
Kasten, M.; Klein, C. The many faces of alpha-synuclein mutations. Mov. Disord. 2013, 28, 697–701.
-
(2013)
Mov. Disord
, vol.28
, pp. 697-701
-
-
Kasten, M.1
Klein, C.2
-
13
-
-
0031990490
-
Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson’s disease
-
Krüger, R.; Kuhn, W.; Müller, T.; Woitalla, D.; Graeber, M.; Kösel, S.; Przuntek, H.; Epplen, J.; Schöls, L.; Riess, O. Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson’s disease. Nat. Genet. 1998, 18, 106–108.
-
(1998)
Nat. Genet
, vol.18
, pp. 106-108
-
-
Krüger, R.1
Kuhn, W.2
Müller, T.3
Woitalla, D.4
Graeber, M.5
Kösel, S.6
Przuntek, H.7
Epplen, J.8
Schöls, L.9
Riess, O.10
-
14
-
-
10744230149
-
The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia
-
Zarranz, J.; Alegre, J.; Gómez-Esteban, J.; Lezcano, E.; Ros, R.; Ampuero, I.; Vidal, L.; Hoenicka, J.; Rodriguez, O.; Atarés, B; et al. The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia. Ann. Neurol. 2004, 55, 164–173.
-
(2004)
Ann. Neurol
, vol.55
, pp. 164-173
-
-
Zarranz, J.1
Alegre, J.2
Gómez-Esteban, J.3
Lezcano, E.4
Ros, R.5
Ampuero, I.6
Vidal, L.7
Hoenicka, J.8
Rodriguez, O.9
Atarés, B.10
-
15
-
-
0030744876
-
Mutation in the α-synuclein gene identified in families with Parkinson’s Disease
-
Polymeropoulos, M.H.; Lavedan, C.; Leroy, E.; Ide, S.E.; Dehejia, A.; Dutra, A.; Pike, B.; Root, H.; Rubenstein, J.; Boyer, R; et al. Mutation in the α-synuclein gene identified in families with Parkinson’s Disease. Science 1997, 276, 2045–2048.
-
(1997)
Science
, vol.276
, pp. 2045-2048
-
-
Polymeropoulos, M.H.1
Lavedan, C.2
Leroy, E.3
Ide, S.E.4
Dehejia, A.5
Dutra, A.6
Pike, B.7
Root, H.8
Rubenstein, J.9
Boyer, R.10
-
16
-
-
84879605541
-
Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson’s disease. Mov
-
Appel-Cresswell, S.; Vilarino-Guell, C.; Encarnacion, M.; Sherman, H.; Yu, I.; Shah, B.; Weir, D.; Thompson, C.; Szu-Tu, C.; Trinh, J; et al. Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson’s disease. Mov. Disord. 2013, 28, 811–813.
-
(2013)
Disord
, vol.28
, pp. 811-813
-
-
Appel-Cresswell, S.1
Vilarino-Guell, C.2
Encarnacion, M.3
Sherman, H.4
Yu, I.5
Shah, B.6
Weir, D.7
Thompson, C.8
Szu-Tu, C.9
Trinh, J.10
-
17
-
-
84878405578
-
G51D α-synuclein mutation causes a novel parkinsonian-pyramidal syndrome
-
Lesage, S.; Anheim, M.; Letournel, F.; Bousset, L.; Honoré, A.; Rozas, N.; Pieri, L.; Madiona, K.; Dürr, A.; Melki, R; et al. G51D α-synuclein mutation causes a novel parkinsonian-pyramidal syndrome. Ann. Neurol. 2013, 73, 459–471.
-
(2013)
Ann. Neurol
, vol.73
, pp. 459-471
-
-
Lesage, S.1
Anheim, M.2
Letournel, F.3
Bousset, L.4
Honoré, A.5
Rozas, N.6
Pieri, L.7
Madiona, K.8
Dürr, A.9
Melki, R.10
-
18
-
-
84886587005
-
Novel A18T and pA29S substitutions in α-synuclein may be associated with sporadic Parkinson’s disease
-
Hoffman-Zacharska, D.; Koziorowski, D.; Ross, O.A.; Milewski, M.; Pozna_ski, J.; Jurek, M.; Wszolek, Z.K.; Soto-Ortolaza, A.; Sβawek, J.; Janik, P; et al. Novel A18T and pA29S substitutions in α-synuclein may be associated with sporadic Parkinson’s disease. Parkinsonism Relat. Disord. 2013, 19, 1057–1060.
-
(2013)
Parkinsonism Relat. Disord
, vol.19
, pp. 1057-1060
-
-
Hoffman-Zacharska, D.1
Koziorowski, D.2
Ross, O.A.3
Milewski, M.4
Poznask, J.5
Jure, M.6
Wszole, Z.K.7
Soto-Ortolazs, A.8
Βawek, J.9
Janik, P.10
-
19
-
-
34250796802
-
The impact of the E46K mutation on the properties of alpha-synuclein in its monomeric and oligomeric states
-
Fredenburg, R.A.; Rospigliosi, C.; Meray, R.K.; Kessler, J.C.; Lashuel, H.A.; Eliezer, D.; Lansbury, P.T.J. The impact of the E46K mutation on the properties of alpha-synuclein in its monomeric and oligomeric states. Biochemistry 2007, 46, 7107–7118.
-
(2007)
Biochemistry
, vol.46
, pp. 7107-7118
-
-
Fredenburg, R.A.1
Rospigliosi, C.2
Meray, R.K.3
Kessler, J.C.4
Lashuel, H.A.5
Eliezer, D.6
Lansbury, P.7
-
20
-
-
59649095836
-
Pathogenic mutations shift the equilibria of alpha-synuclein single molecules towards structured conformers
-
Brucale, M.; Sandal, M.; di Maio, S.; Rampioni, A.; Tessari, I.; Tosatto, L.; Bisaglia, M.; Bubacco, L.; Samorì, B. Pathogenic mutations shift the equilibria of alpha-synuclein single molecules towards structured conformers. Chembiochem 2009, 10, 176–183.
-
(2009)
Chembiochem
, vol.10
, pp. 176-183
-
-
Brucale, M.1
Sandal, M.2
Di Maio, S.3
Rampioni, A.4
Tessari, I.5
Tosatto, L.6
Bisaglia, M.7
Bubacco, L.8
Samorì, B.9
-
21
-
-
0035949542
-
Effect of familial Parkinson’s Disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human α-synuclein
-
Li, J.; Uversky, V.N.; Fink, A.L. Effect of familial Parkinson’s Disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human α-synuclein. Biochemistry 2001, 40, 11604–11613.
-
(2001)
Biochemistry
, vol.40
, pp. 11604-11613
-
-
Li, J.1
Uversky, V.N.2
Fink, A.L.3
-
22
-
-
33746869343
-
Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson Disease
-
Maraganore, D.M.; de Andrade, M.; Elbaz, A.; Farrer, M.J.; Ioannidis, J.P.; Krüger, R.; Rocca, W.A.; Schneider, N.K.; Lesnick, T.G.; Lincoln, S.J; et al. Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson Disease. JAMA 2006, 296, 661–670.
-
(2006)
JAMA
, vol.296
, pp. 661-670
-
-
Maraganore, D.M.1
De Andrade, M.2
Elbaz, A.3
Farrer, M.J.4
Ioannidis, J.P.5
Krüger, R.6
Rocca, W.A.7
Schneider, N.K.8
Lesnick, T.G.9
Lincoln, S.J.10
-
23
-
-
77951842993
-
Methylation regulates alpha-synuclein expression and is decreased in Parkinson’s disease patients’ brains
-
Jowaed, A.; Schmitt, I.; Kaut, O.; Wüllner, U. Methylation regulates alpha-synuclein expression and is decreased in Parkinson’s disease patients’ brains. J. Neurosci. 2010, 30, 6355–6359.
-
(2010)
J. Neurosci
, vol.30
, pp. 6355-6359
-
-
Jowaed, A.1
Schmitt, I.2
Kaut, O.3
Wüllner, U.4
-
24
-
-
63449129338
-
Physiological and pathological role of alpha-synuclein in Parkinson’s disease through iron mediated oxidative stress; the role of a putative iron-responsive element
-
Olivares, D.; Huang, X.; Branden, L.; Greig, N.H.; Rogers, J.T. Physiological and pathological role of alpha-synuclein in Parkinson’s disease through iron mediated oxidative stress; the role of a putative iron-responsive element. Int. J. Mol. Sci. 2009, 10, 1226–1260.
-
(2009)
Int. J. Mol. Sci
, vol.10
, pp. 1226-1260
-
-
Olivares, D.1
Huang, X.2
Branden, L.3
Greig, N.H.4
Rogers, J.T.5
-
25
-
-
84907699043
-
Transglutaminase 2 exacerbates α-synuclein toxicity in mice and yeast
-
Grosso, H.; Woo, J.M.; Lee, K.W.; Im, J.Y.; Masliah, E.; Junn, E.; Mouradian, M.M. Transglutaminase 2 exacerbates α-synuclein toxicity in mice and yeast. FASEB J. 2014, 28, 4280–4291.
-
(2014)
FASEB J
, vol.28
, pp. 4280-4291
-
-
Grosso, H.1
Woo, J.M.2
Lee, K.W.3
Im, J.Y.4
Masliah, E.5
Junn, E.6
Mouradian, M.M.7
-
26
-
-
84859577559
-
α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer
-
Fauvet, B.; Mbefo, M.K.; Fares, M.-B.; Desobry, C.; Michael, S.; Ardah, M.T.; Tsika, E.; Coune, P.; Prudent, M.; Lion, N; et al. α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer. J. Biol. Chem. 2012, 287, 15345–15364.
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 15345-15364
-
-
Fauvet, B.1
Mbefo, M.K.2
Fares, M.-B.3
Desobry, C.4
Michael, S.5
Ardah, M.T.6
Tsika, E.7
Coune, P.8
Prudent, M.9
Lion, N.10
-
27
-
-
83455202793
-
α-synuclein misfolding and Parkinson’s disease. Biochim.Biophys
-
Breydo, L.; Wu, J.W.; Uversky, V.N. α-synuclein misfolding and Parkinson’s disease. Biochim.Biophys. Acta 2012, 1822, 261–285.
-
(2012)
Acta
, vol.1822
, pp. 261-285
-
-
Breydo, L.1
Wu, J.W.2
Uversky, V.N.3
-
28
-
-
80053912079
-
Effect of Ser-129 phosphorylation on interaction of α-synuclein with synaptic and cellular membranes
-
Visanji, N.P.; Wislet-Gendebien, S.; Oschipok, L.W.; Zhang, G.; Aubert, I.; Fraser, P.E.; Tandon, A. Effect of Ser-129 phosphorylation on interaction of α-synuclein with synaptic and cellular membranes. J. Biol. Chem. 2011, 286, 35863–35873.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 35863-35873
-
-
Visanji, N.P.1
Wislet-Gendebien, S.2
Oschipok, L.W.3
Zhang, G.4
Aubert, I.5
Fraser, P.E.6
Tandon, A.7
-
29
-
-
84892794505
-
The N-terminus of α-synuclein is essential for both monomeric and oligomeric interactions with membranes
-
Lorenzen, N.; Lemminger, L.; Pedersen, J.N.; Nielsen, S.B.; Otzen, D.E. The N-terminus of α-synuclein is essential for both monomeric and oligomeric interactions with membranes. FEBS Lett. 2014, 588, 497–502.
-
(2014)
FEBS Lett
, vol.588
, pp. 497-502
-
-
Lorenzen, N.1
Lemminger, L.2
Pedersen, J.N.3
Nielsen, S.B.4
Otzen, D.E.5
-
30
-
-
77958455514
-
Rhoades, E. Effects of curvature and composition on α-synuclein binding to lipid vesicles
-
Middleton, E.R.; Rhoades, E. Effects of curvature and composition on α-synuclein binding to lipid vesicles. Biophys. J. 2010, 99, 2279–2288.
-
(2010)
Biophys. J.
, vol.99
, pp. 2279-2288
-
-
Middleton, E.R.1
-
31
-
-
84884250340
-
The function of α-synuclein
-
Bendor, J.T.; Logan, T.P.; Edwards, R.H. The function of α-synuclein. Neuron 2013, 79, 1044–1066.
-
(2013)
Neuron
, vol.79
, pp. 1044-1066
-
-
Bendor, J.T.1
Logan, T.P.2
Edwards, R.H.3
-
32
-
-
77957347060
-
α-synuclein promotes SNARE-complex assembly in vivo and in vitro
-
Burré, J.; Sharma, M.; Tsetsenis, T.; Buchman, V.; Etherton, M.R.; Südhof, T.C. α-synuclein promotes SNARE-complex assembly in vivo and in vitro. Science 2010, 329, 1663–1667.
-
(2010)
Science
, vol.329
, pp. 1663-1667
-
-
Burré, J.1
Sharma, M.2
Tsetsenis, T.3
Buchman, V.4
Etherton, M.R.5
Südhof, T.C.6
-
33
-
-
84919449363
-
α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation
-
Burré, J.; Sharma, M.; Südhof, T.C. α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation. Proc. Natl. Acad. Sci. USA 2014, 111, 4274–4283.
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.111
, pp. 4274-4283
-
-
Burré, J.1
Sharma, M.2
Südhof, T.C.3
-
34
-
-
78650763561
-
Membrane permeabilization byoligomeric α-synuclein: In search of the mechanism
-
Van Rooijen, B.D.; Claessens, M.M.A.E.; Subramaniam, V. Membrane permeabilization byoligomeric α-synuclein: In search of the mechanism. PLOS ONE 2010, 5, e14292.
-
(2010)
PLOS ONE
, vol.5
-
-
Van Rooijen, B.D.1
Claessens, M.2
Subramaniam, V.3
-
35
-
-
84880521916
-
α-Synuclein senses lipid packing defects and induces lateral expansion of lipids leading to membrane remodeling
-
Ouberai, M.M.; Wang, J.; Swann, M.J.; Galvagnion, C.; Guilliams, T.; Dobson, C.M.; Welland, M.E. α-Synuclein senses lipid packing defects and induces lateral expansion of lipids leading to membrane remodeling. J. Biol. Chem. 2013, 288, 20883–20895.
-
(2013)
J. Biol. Chem
, vol.288
, pp. 20883-20895
-
-
Ouberai, M.M.1
Wang, J.2
Swann, M.J.3
Galvagnion, C.4
Guilliams, T.5
Dobson, C.M.6
Welland, M.E.7
-
36
-
-
77956571912
-
Redox reactions of the α-synuclein-Cu2+ complex and their effects on neuronal cell viability
-
Wang, C.; Liu, L.; Zhang, L.; Peng, Y.; Zhou, F. Redox reactions of the α-synuclein-Cu2+ complex and their effects on neuronal cell viability. Biochemistry 2011, 49, 323–343.
-
(2011)
Biochemistry
, vol.49
, pp. 323-343
-
-
Wang, C.1
Liu, L.2
Zhang, L.3
Peng, Y.4
Zhou, F.5
-
37
-
-
84872595532
-
Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia
-
Fellner, L.; Irschick, R.; Schanda, K.; Reindl, M.; Klimaschewski, L.; Poewe, W.; Wenning, G.K.; Stefanova, N. Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia. Glia 2013, 61, 349–360.
-
(2013)
Glia
, vol.61
, pp. 349-360
-
-
Fellner, L.1
Irschick, R.2
Schanda, K.3
Reindl, M.4
Klimaschewski, L.5
Poewe, W.6
Wenning, G.K.7
Stefanova, N.8
-
38
-
-
78149441914
-
Glial innate immunitygenerated by non-aggregated alpha-synuclein in mouse: Differences between wild-type and Parkinson’s disease-linked mutants
-
Roodveldt, C.; Labrador-Garrido, A.; Gonzalez-Rey, E.; Fernandez-Montesinos, R.; Caro, M.; Lachaud, C.C.; Waudby, C.A.; Delgado, M.; Dobson, C.M.; Pozo, D. Glial innate immunitygenerated by non-aggregated alpha-synuclein in mouse: Differences between wild-type and Parkinson’s disease-linked mutants. PLOS ONE 2010, 5, e13481.
-
(2010)
PLOS ONE
, vol.5
, pp. 13481
-
-
Roodveldt, C.1
Labrador-Garrido, A.2
Gonzalez-Rey, E.3
Fernandez-Montesinos, R.4
Caro, M.5
Lachaud, C.C.6
Waudby, C.A.7
Delgado, M.8
Dobson, C.M.9
Pozo, D.10
-
39
-
-
0034674652
-
Dityrosine cross-linking promotes formation of stable alpha-synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies
-
Souza, J.M.; Giasson, B.I.; Chen, Q.; Lee, V.M.; Ischiropoulos, H. Dityrosine cross-linking promotes formation of stable alpha-synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies. J. Biol. Chem. 2000, 275, 18344–18349.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 18344-18349
-
-
Souza, J.M.1
Giasson, B.I.2
Chen, Q.3
Lee, V.M.4
Ischiropoulos, H.5
-
40
-
-
84886777232
-
Alpha-synuclein misfolding assessed with single molecule AFM force spectroscopy: Effect of pathogenic mutations
-
Krasnoslobodtsev, A.V.; Volkov, I.L.; Asiago, J.M.; Hindupur, J.; Rochet, J.-C.; Lyubchenko, Y.L. Alpha-synuclein misfolding assessed with single molecule AFM force spectroscopy: Effect of pathogenic mutations. Biochemistry 2013, 52, 1–22.
-
(2013)
Biochemistry
, vol.52
, pp. 1-22
-
-
Krasnoslobodtsev, A.V.1
Volkov, I.L.2
Asiago, J.M.3
Hindupur, J.4
Rochet, J.-C.5
Lyubchenko, Y.L.6
-
41
-
-
79957974579
-
Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein alpha-synuclein
-
Nakamura, K.; Nemani, V.M.; Azarbal, F.; Skibinski, G.; Levy, J.M.; Egami, K.; Munishkina, L.; Zhang, J.; Gardner, B.; Wakabayashi, J; et al. Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein alpha-synuclein. J. Biol. Chem. 2011, 286, 20710–20726.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 20710-20726
-
-
Nakamura, K.1
Nemani, V.M.2
Azarbal, F.3
Skibinski, G.4
Levy, J.M.5
Egami, K.6
Munishkina, L.7
Zhang, J.8
Gardner, B.9
Wakabayashi, J.10
-
42
-
-
80052398365
-
α-synuclein occurs as a helically folded tetramer that resists aggregation
-
Bartels, T.; Choi, J.G.; Selkoe, D.J. α-synuclein occurs as a helically folded tetramer that resists aggregation. Nature 2012, 477, 107–110.
-
(2012)
Nature
, vol.477
, pp. 107-110
-
-
Bartels, T.1
Choi, J.G.2
Selkoe, D.J.3
-
43
-
-
84874769548
-
In vivo cross-linking reveals principally oligomeric forms of α-synuclein and β-synuclein in neurons and non-neural cells
-
Dettmer, U.; Newman, A.J.; Luth, E.S.; Bartels, T.; Selkoe, D. In vivo cross-linking reveals principally oligomeric forms of α-synuclein and β-synuclein in neurons and non-neural cells. J. Biol. Chem. 2013, 288, 6371–6385.
-
(2013)
J. Biol. Chem
, vol.288
, pp. 6371-6385
-
-
Dettmer, U.1
Newman, A.J.2
Luth, E.S.3
Bartels, T.4
Selkoe, D.5
-
44
-
-
84896267689
-
Evidence ofnative α-synuclein conformers in the human brain
-
Gould, N.; Mor, D.E.; Lightfoot, R.; Malkus, K.; Giasson, B.; Ischiropoulos, H. Evidence ofnative α-synuclein conformers in the human brain. J. Biol. Chem. 2014, 289, 7929–7934.
-
(2014)
J. Biol. Chem
, vol.289
, pp. 7929-7934
-
-
Gould, N.1
Mor, D.E.2
Lightfoot, R.3
Malkus, K.4
Giasson, B.5
Ischiropoulos, H.6
-
45
-
-
84878910950
-
α-Synuclein mutations cluster around a putative protein loop
-
Kara, E.; Lewis, P.A.; Ling, H.; Proukakis, C.; Houlden, H.; Hardy, J. α-Synuclein mutations cluster around a putative protein loop. Neurosci. Lett. 2013, 546, 67–70.
-
(2013)
Neurosci. Lett
, vol.546
, pp. 67-70
-
-
Kara, E.1
Lewis, P.A.2
Ling, H.3
Proukakis, C.4
Houlden, H.5
Hardy, J.6
-
46
-
-
84861563520
-
Direct observation of the interconversion of normal and toxic forms of α-synuclein
-
Cremades, N.; Cohen, S.I.A.; Deas, E.; Abramov, A.Y.; Chen, A.Y.; Orte, A.; Sandal, M.; Clarke, R.W.; Dunne, P.; Aprile, F.A; et al. Direct observation of the interconversion of normal and toxic forms of α-synuclein. Cell 2012, 149, 1048–1059.
-
(2012)
Cell
, vol.149
, pp. 1048-1059
-
-
Cremades, N.1
Cohen, S.2
Deas, E.3
Abramov, A.Y.4
Chen, A.Y.5
Orte, A.6
Sandal, M.7
Clarke, R.W.8
Dunne, P.9
Aprile, F.A.10
-
47
-
-
84896265204
-
The role of stable α-synuclein oligomers in the molecular events underlying amyloid formation
-
Lorenzen, N.; Nielsen, S.B.; Buell, A.K.; Kaspersen, J.D.; Arosio, P.; Vad, B.S.; Paslawski, W.; Christiansen, G.; Valnickova-Hansen, Z.; Andreasen, M; et al. The role of stable α-synuclein oligomers in the molecular events underlying amyloid formation. J. Am. Chem. Soc. 2014, 136, 3859–3868.
-
(2014)
J. Am. Chem. Soc.
, vol.136
, pp. 3859-3868
-
-
Lorenzen, N.1
Nielsen, S.B.2
Buell, A.K.3
Kaspersen, J.D.4
Arosio, P.5
Vad, B.S.6
Paslawski, W.7
Christiansen, G.8
Valnickova-Hansen, Z.9
Andreasen, M.10
-
48
-
-
0036415838
-
α-Synuclein, especially the Parkinson’s disease-associated mutants, forms pore-like annular and tubular protofibrils
-
Lashuel, H.A.; Petre, B.M.; Wall, J.; Simon, M.; Nowak, R.J.; Walz, T.; Lansbury, P.T. α-Synuclein, especially the Parkinson’s disease-associated mutants, forms pore-like annular and tubular protofibrils. J. Mol. Biol. 2002, 322, 1089–1102.
-
(2002)
J. Mol. Biol
, vol.322
, pp. 1089-1102
-
-
Lashuel, H.A.1
Petre, B.M.2
Wall, J.3
Simon, M.4
Nowak, R.J.5
Walz, T.6
Lansbury, P.T.7
-
49
-
-
1842424791
-
Proteasomal inhibition by alpha-synuclein filaments and oligomers
-
Lindersson, E.; Beedholm, R.; Højrup, P.; Moos, T.; Gai, W.; Hendil, K.B.; Jensen, P.H. Proteasomal inhibition by alpha-synuclein filaments and oligomers. J. Biol. Chem. 2004, 279, 12924–12934.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 12924-12934
-
-
Lindersson, E.1
Beedholm, R.2
Højrup, P.3
Moos, T.4
Gai, W.5
Hendil, K.B.6
Jensen, P.H.7
-
50
-
-
77955881152
-
Binding reveals common features of cytotoxic amyloid species. ACS
-
Bolognesi, B.; Kumita, J.R.; Barros, T.P.; Esbjorner, E.K.; Luheshi, L.M.; Crowther, D.C.; Wilson, M.R.; Dobson, C.M.; Favrin, G.; Yerbury, J.J. ANS binding reveals common features of cytotoxic amyloid species. ACS Chem. Biol. 2010, 5, 735–740.
-
(2010)
Chem. Biol
, vol.5
, pp. 735-740
-
-
Bolognesi, B.1
Kumita, J.R.2
Barros, T.P.3
Esbjorner, E.K.4
Luheshi, L.M.5
Crowther, D.C.6
Wilson, M.R.7
Dobson, C.M.8
Favrin, G.9
Yerbury, J.10
-
51
-
-
65249162241
-
Detection of elevated levels of soluble alpha-synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies
-
Paleologou, K.E.; Kragh, C.L.; Mann, D.M.A.; Salem, S.A.; Al-Shami, R.; Allsop, D.; Hassan, A.H.; Jensen, P.H.; El-Agnaf, O.M.A. Detection of elevated levels of soluble alpha-synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies. Brain 2009, 132, 1093–1101.
-
(2009)
Brain
, vol.132
, pp. 1093-1101
-
-
Paleologou, K.E.1
Kragh, C.L.2
Mann, D.3
Salem, S.A.4
Al-Shami, R.5
Allsop, D.6
Hassan, A.H.7
Jensen, P.H.8
El-Agnaf, O.9
-
52
-
-
65549114936
-
Lipid bilayer disruption by oligomeric alpha-synuclein depends on bilayer charge and accessibility of the hydrophobic core
-
Van Rooijen, B.D.; Claessens, M.M.A.E.; Subramaniam, V. Lipid bilayer disruption by oligomeric alpha-synuclein depends on bilayer charge and accessibility of the hydrophobic core. Biochim. Biophys. Acta 2009, 1788, 1271–1278.
-
(2009)
Biochim. Biophys. Acta
, vol.1788
, pp. 1271-1278
-
-
Van Rooijen, B.D.1
Claessens, M.2
Subramaniam, V.3
-
53
-
-
34548172773
-
Different species of α-synuclein oligomers induce calcium influx and seeding
-
Danzer, K.M.; Haasen, D.; Karow, A.R.; Moussaud, S.; Habeck, M.; Giese, A.; Kretzschmar, H.; Hengerer, B.; Kostka, M. Different species of α-synuclein oligomers induce calcium influx and seeding. J. Neurosci. 2007, 27, 9220–9232.
-
(2007)
J. Neurosci
, vol.27
, pp. 9220-9232
-
-
Danzer, K.M.1
Haasen, D.2
Karow, A.R.3
Moussaud, S.4
Habeck, M.5
Giese, A.6
Kretzschmar, H.7
Hengerer, B.8
Kostka, M.9
-
54
-
-
44849084558
-
Single particle characterization of iron-induced pore-forming alpha-synuclein oligomers
-
Kostka, M.; Högen, T.; Danzer, K.M.; Levin, J.; Habeck, M.; Wirth, A.; Wagner, R.; Glabe, C.G.; Finger, S.; Heinzelmann, U; et al. Single particle characterization of iron-induced pore-forming alpha-synuclein oligomers. J. Biol. Chem. 2008, 283, 10992–11003.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 10992-11003
-
-
Kostka, M.1
Högen, T.2
Danzer, K.M.3
Levin, J.4
Habeck, M.5
Wirth, A.6
Wagner, R.7
Glabe, C.G.8
Finger, S.9
Heinzelmann, U.10
-
55
-
-
84874611934
-
Large α-synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking
-
Choi, B.-K.; Choi, M.-G.; Kim, J.-Y.; Yang, Y.; Lai, Y.; Kweon, D.-H.; Lee, N.K.; Shin, Y.-K. Large α-synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking. Proc. Natl. Acad. Sci. USA 2013, 110, 4087–4092.
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 4087-4092
-
-
Choi, B.-K.1
Choi, M.-G.2
Kim, J.-Y.3
Yang, Y.4
Lai, Y.5
Kweon, D.-H.6
Lee, N.K.7
Shin, Y.-K.8
-
56
-
-
84879229182
-
In vitro study of α-synuclein protofibrils by cryo-EM suggests a Cu2+-dependent aggregation pathway
-
Zhang, H.; Griggs, A.; Rochet, J.-C.; Stanciu, L.A. In vitro study of α-synuclein protofibrils by cryo-EM suggests a Cu2+-dependent aggregation pathway. Biophys. J. 2013, 104, 2706–2713.
-
(2013)
Biophys. J
, vol.104
, pp. 2706-2713
-
-
Zhang, H.1
Griggs, A.2
Rochet, J.-C.3
Stanciu, L.A.4
-
57
-
-
84887124634
-
The interplay between lipids and dopamine on α-synuclein oligomerization and membrane binding
-
Pham, C.L.L.; Cappai, R. The interplay between lipids and dopamine on α-synuclein oligomerization and membrane binding. Biosci. Rep. 2013, 33, 807–814.
-
(2013)
Biosci. Rep
, vol.33
, pp. 807-814
-
-
Pham, C.1
Cappai, R.2
-
58
-
-
68849102707
-
Unique copper-induced oligomers mediate alpha-synuclein toxicity
-
Wright, J.A.; Wang, X.; Brown, D.R. Unique copper-induced oligomers mediate alpha-synuclein toxicity. FASEB J. 2009, 23, 2384–2393.
-
(2009)
FASEB J
, vol.23
, pp. 2384-2393
-
-
Wright, J.A.1
Wang, X.2
Brown, D.R.3
-
59
-
-
77950644314
-
Copper binding regulates intracellular alpha-synuclein localisation, aggregation and toxicity
-
Wang, X.; Moualla, D.; Wright, J.A.; Brown, D.R. Copper binding regulates intracellular alpha-synuclein localisation, aggregation and toxicity. J. Neurochem. 2010, 113, 704–714.
-
(2010)
J. Neurochem
, vol.113
, pp. 704-714
-
-
Wang, X.1
Moualla, D.2
Wright, J.A.3
Brown, D.R.4
-
60
-
-
75349097530
-
A causative link between the structure of aberrant protein oligomers and their toxicity
-
Campioni, S.; Mannini, B.; Zampagni, M.; Pensalfini, A.; Parrini, C.; Evangelisti, E.; Relini, A.; Stefani, M.; Dobson, C.M.; Cecchi, C.; et al. A causative link between the structure of aberrant protein oligomers and their toxicity. Nat. Chem. Biol. 2010, 6, 140–147.
-
(2010)
Nat. Chem. Biol.
, vol.6
, pp. 140-147
-
-
Campioni, S.1
Mannini, B.2
Zampagni, M.3
Pensalfini, A.4
Parrini, C.5
Evangelisti, E.6
Relini, A.7
Stefani, M.8
Dobson, C.M.9
Cecchi, C.10
-
61
-
-
80053289958
-
A comparison of the biochemical modifications caused by toxic and non-toxic protein oligomers in cells
-
Zampagni, M.; Cascella, R.; Casamenti, F.; Grossi, C.; Evangelisti, E.; Wright, D.; Becatti, M.; Liguri, G.; Mannini, B.; Campioni, S; et al. A comparison of the biochemical modifications caused by toxic and non-toxic protein oligomers in cells. J. Cell. Mol. Med. 2011, 15, 2106–2116.
-
(2011)
J. Cell. Mol. Med.
, vol.15
, pp. 2106-2116
-
-
Zampagni, M.1
Cascella, R.2
Casamenti, F.3
Grossi, C.4
Evangelisti, E.5
Wright, D.6
Becatti, M.7
Liguri, G.8
Mannini, B.9
Campioni, S.10
-
62
-
-
78650963274
-
Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions
-
Olzscha, H.; Schermann, S.M.; Woerner, A.C.; Pinkert, S.; Hecht, M.H.; Tartaglia, G.G.; Vendruscolo, M.; Hayer-Hartl, M.; Hartl, F.U.; Vabulas, R.M. Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions. Cell 2011, 144, 67–78.
-
(2011)
Cell
, vol.144
, pp. 67-78
-
-
Olzscha, H.1
Schermann, S.M.2
Woerner, A.C.3
Pinkert, S.4
Hecht, M.H.5
Tartaglia, G.G.6
Vendruscolo, M.7
Hayer-Hartl, M.8
Hartl, F.U.9
Vabulas, R.M.10
-
63
-
-
33947210032
-
Dynamics of alpha-synuclein aggregation and inhibition of pore-like oligomer development by beta-synuclein
-
Tsigelny, I.F.; Bar-On, P.; Sharikov, Y.; Crews, L.; Hashimoto, M.; Miller, M.A.; Keller, S.H.; Platoshyn, O.; Yuan, J.X.-J.; Masliah, E. Dynamics of alpha-synuclein aggregation and inhibition of pore-like oligomer development by beta-synuclein. FEBS J. 2007, 274, 1862–1877.
-
(2007)
FEBS J
, vol.274
, pp. 1862-1877
-
-
Tsigelny, I.F.1
Bar-On, P.2
Sharikov, Y.3
Crews, L.4
Hashimoto, M.5
Miller, M.A.6
Keller, S.H.7
Platoshyn, O.8
Yuan, J.X.9
Masliah, E.10
-
64
-
-
84858441755
-
Role of alpha-synuclein penetration into the membrane in the mechanisms of oligomer pore formation
-
Tsigelny, I.F.; Sharikov, Y.; Wrasidlo, W.; Gonzalez, T.; Desplats, P.A.; Spencer, B.; Masliah, E. Role of alpha-synuclein penetration into the membrane in the mechanisms of oligomer pore formation. FEBS J. 2012, 279, 1000–1013.
-
(2012)
FEBS J
, vol.279
, pp. 1000-1013
-
-
Tsigelny, I.F.1
Sharikov, Y.2
Wrasidlo, W.3
Gonzalez, T.4
Desplats, P.A.5
Spencer, B.6
Masliah, E.7
-
65
-
-
77955312210
-
Amyloidogenic protein-membrane interactions: Mechanistic insight from model systems
-
Butterfield, S.M.; Lashuel, H.A. Amyloidogenic protein-membrane interactions: Mechanistic insight from model systems. Angew. Chem. Int. Ed. Engl. 2010, 49, 5628–5654.
-
(2010)
Angew. Chem. Int. Ed. Engl
, vol.49
, pp. 5628-5654
-
-
Butterfield, S.M.1
Lashuel, H.A.2
-
66
-
-
84864538288
-
Single-channel electrophysiology reveals a distinct and uniform pore complex formed by α-synuclein oligomers in lipid membranes
-
Schmidt, F.; Levin, J.; Kamp, F.; Kretzschmar, H.; Giese, A.; Bötzel, K. Single-channel electrophysiology reveals a distinct and uniform pore complex formed by α-synuclein oligomers in lipid membranes. PLOS ONE 2012, 7, e42545.
-
(2012)
PLOS ONE
, pp. 7
-
-
Schmidt, F.1
Levin, J.2
Kamp, F.3
Kretzschmar, H.4
Giese, A.5
Bötzel, K.6
-
67
-
-
36249023636
-
Pore-forming proteins share structural and functional homology with amyloid oligomers
-
Yoshiike, Y.; Kayed, R.; Milton, S.C.; Takashima, A.; Glabe, C.G. Pore-forming proteins share structural and functional homology with amyloid oligomers. Neuromol. Med. 2007, 9, 270–275.
-
(2007)
Neuromol. Med
, vol.9
, pp. 270-275
-
-
Yoshiike, Y.1
Kayed, R.2
Milton, S.C.3
Takashima, A.4
Glabe, C.G.5
-
68
-
-
8744220663
-
Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseases
-
Kayed, R.; Sokolov, Y.; Edmonds, B.; McIntire, T.M.; Milton, S.C.; Hall, J.E.; Glabe, C.G. Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseases. J. Biol. Chem. 2004, 279, 46363–46366.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 46363-46366
-
-
Kayed, R.1
Sokolov, Y.2
Edmonds, B.3
McIntire, T.M.4
Milton, S.C.5
Hall, J.E.6
Glabe, C.G.7
-
69
-
-
33751516396
-
Soluble amyloid oligomers increase bilayer conductance by altering dielectric structure
-
Sokolov, Y.; Kozak, J.A.; Kayed, R.; Chanturiya, A.; Glabe, C.; Hall, J.E. Soluble amyloid oligomers increase bilayer conductance by altering dielectric structure. J. Gen. Physiol. 2006, 128, 637–647.
-
(2006)
J. Gen. Physiol
, vol.128
, pp. 637-647
-
-
Sokolov, Y.1
Kozak, J.A.2
Kayed, R.3
Chanturiya, A.4
Glabe, C.5
Hall, J.E.6
-
70
-
-
63649147251
-
Amyloid-β-induced ion flux in artificial lipid bilayers and neuronal cells: Resolving a controversy
-
Capone, R.; Quiroz, F.G.; Prangkio, P.; Saluja, I.; Anna, M.; Bautista, M.R.; Turner, R.S.; Yang, J.; Mayer, M. Amyloid-β-induced ion flux in artificial lipid bilayers and neuronal cells: Resolving a controversy. Neurotox. Res. 2009, 16, 1–13.
-
(2009)
Neurotox. Res
, vol.16
, pp. 1-13
-
-
Capone, R.1
Quiroz, F.G.2
Prangkio, P.3
Saluja, I.4
Anna, M.5
Bautista, M.R.6
Turner, R.S.7
Yang, J.8
Mayer, M.9
-
71
-
-
84876891740
-
α-Synuclein oligomers: An amyloid pore? Insights into mechanisms of α-synuclein oligomer-lipid interactions
-
Zijlstra, N.; Subramaniam, V. α-Synuclein oligomers: An amyloid pore? Insights into mechanisms of α-synuclein oligomer-lipid interactions. Mol. Neurobiol. 2013, 47, 613–621.
-
(2013)
Mol. Neurobiol
, vol.47
, pp. 613-621
-
-
Zijlstra, N.1
Subramaniam, V.2
-
72
-
-
82655175456
-
Kinetic measurements give new insights into lipid membrane permeabilization by α-synuclein oligomers
-
Stöckl, M.; Claessens, M.M.A.E.; Subramaniam, V. Kinetic measurements give new insights into lipid membrane permeabilization by α-synuclein oligomers. Mol. Biosyst. 2012, 8, 338–345.
-
(2012)
Mol. Biosyst
, vol.8
, pp. 338-345
-
-
Stöckl, M.1
Claessens, M.2
Subramaniam, V.3
-
73
-
-
84879918450
-
α-Synuclein and mitochondria: Partners in crime?
-
Nakamura, K. α-Synuclein and mitochondria: Partners in crime? Neurotherapeutics 2013, 10, 391–399.
-
(2013)
Neurotherapeutics
, vol.10
, pp. 391-399
-
-
Nakamura, K.1
-
74
-
-
44049099669
-
Mitochondrial import and accumulation of α-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain
-
Devi, L.; Raghavendran, V.; Prabhu, B.M.; Avadhani, N.G.; Anandatheerthavarada, H.K. Mitochondrial import and accumulation of α-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain. J. Biol. Chem. 2008, 283, 9089–9100.
-
(2008)
J. Biol. Chem
, vol.283
, pp. 9089-9100
-
-
Devi, L.1
Raghavendran, V.2
Prabhu, B.M.3
Avadhani, N.G.4
Anandatheerthavarada, H.K.5
-
75
-
-
84877130674
-
Impairment of mitochondria in adult mouse brainoverexpressing predominantly full-length, N-terminally acetylated human α-synuclein
-
Sarafian, T.A.; Ryan, C.M.; Souda, P.; Masliah, E.; Kar, U.K.; Vinters, H.V.; Mathern, G.W.; Faull, K.F.; Whitelegge, J.P.; Watson, J.B. Impairment of mitochondria in adult mouse brainoverexpressing predominantly full-length, N-terminally acetylated human α-synuclein. PLOS ONE 2013, 8, e63557.
-
(2013)
PLOS ONE
, vol.8
-
-
Sarafian, T.A.1
Ryan, C.M.2
Souda, P.3
Masliah, E.4
Kar, U.K.5
Vinters, H.V.6
Mathern, G.W.7
Faull, K.F.8
Whitelegge, J.P.9
Watson, J.B.10
-
76
-
-
84905372211
-
Soluble, prefibrillar α-synuclein oligomers promote complex I-dependent, Ca2+-induced mitochondrial dysfunction
-
Luth, E.S.; Stavrovskaya, I.G.; Bartels, T.; Kristal, B.S.; Selkoe, D.J. Soluble, prefibrillar α-synuclein oligomers promote complex I-dependent, Ca2+-induced mitochondrial dysfunction. J. Biol. Chem. 2014, 289, 21490–21507.
-
(2014)
J. Biol. Chem
, vol.289
, pp. 21490-21507
-
-
Luth, E.S.1
Stavrovskaya, I.G.2
Bartels, T.3
Kristal, B.S.4
Selkoe, D.J.5
-
77
-
-
84887706170
-
The rescue of microtubule-dependent traffic recovers mitochondrial function in Parkinson’s disease
-
Esteves, A.R.; Gozes, I.; Cardoso, S.M. The rescue of microtubule-dependent traffic recovers mitochondrial function in Parkinson’s disease. Biochim. Biophys. Acta 2014, 1842, 7–21.
-
(2014)
Biochim. Biophys. Acta
, vol.1842
, pp. 7-21
-
-
Esteves, A.R.1
Gozes, I.2
Cardoso, S.M.3
-
78
-
-
20144389524
-
Aggregated alpha-synuclein activates microglia: A process leading to disease progression in Parkinson’s disease
-
Zhang, W.; Wang, T.; Pei, Z.; Miller, D.S.; Wu, X.; Block, M.L.; Wilson, B.; Zhang, W.; Zhou, Y.; Hong, J.-S; et al. Aggregated alpha-synuclein activates microglia: A process leading to disease progression in Parkinson’s disease. FASEB J. 2005, 19, 533–542.
-
(2005)
FASEB J
, vol.19
, pp. 533-542
-
-
Zhang, W.1
Wang, T.2
Pei, Z.3
Miller, D.S.4
Wu, X.5
Block, M.L.6
Wilson, B.7
Zhang, W.8
Zhou, Y.9
Hong, J.-S.10
-
79
-
-
33947625072
-
Oligomeric alpha-synuclein inhibits tubulin polymerization. Biochem. Biophys. Res
-
Chen, L.; Jin, J.; Davis, J.; Zhou, Y.; Wang, Y.; Liu, J.; Lockhart, P.J.; Zhang, J. Oligomeric alpha-synuclein inhibits tubulin polymerization. Biochem. Biophys. Res. Commun. 2007, 356, 548–553.
-
(2007)
Commun
, vol.356
, pp. 548-553
-
-
Chen, L.1
Jin, J.2
Davis, J.3
Zhou, Y.4
Wang, Y.5
Liu, J.6
Lockhart, P.J.7
Zhang, J.8
-
80
-
-
84881259462
-
α-Synuclein oligomers impair neuronal microtubule-kinesin interplay
-
Prots, I.; Veber, V.; Brey, S.; Campioni, S.; Buder, K.; Riek, R.; Böhm, K.J.; Winner, B. α-Synuclein oligomers impair neuronal microtubule-kinesin interplay. J. Biol. Chem. 2013, 288, 21742–21754.
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 21742-21754
-
-
Prots, I.1
Veber, V.2
Brey, S.3
Campioni, S.4
Buder, K.5
Riek, R.6
Böhm, K.J.7
Winner, B.8
-
81
-
-
0037040491
-
Human alpha-synuclein over-expression increases intracellular reactive oxygen species levels and susceptibility to dopamine
-
Junn, E.; Mouradian, M.M. Human alpha-synuclein over-expression increases intracellular reactive oxygen species levels and susceptibility to dopamine. Neurosci. Lett. 2002, 320, 146–150.
-
(2002)
Neurosci. Lett
, vol.320
, pp. 146-150
-
-
Junn, E.1
Mouradian, M.M.2
-
82
-
-
84859250911
-
NADPH oxidase 1-mediated oxidative stress leads to dopamine neuron death in Parkinson’s disease. Antioxid
-
Choi, D.-H.; Cristóvão, A.C.; Guhathakurta, S.; Lee, J.; Joh, T.H.; Beal, M.F.; Kim, Y.-S. NADPH oxidase 1-mediated oxidative stress leads to dopamine neuron death in Parkinson’s disease. Antioxid. Redox Signal. 2012, 16, 1033–1045.
-
(2012)
Redox Signal
, vol.16
, pp. 1033-1045
-
-
Choi, D.-H.1
Cristóvão, A.C.2
Guhathakurta, S.3
Lee, J.4
Joh, T.H.5
Beal, M.F.6
Kim, Y.-S.7
-
83
-
-
84874654334
-
Microglial activation and antioxidant responses induced by the Parkinson’s disease protein α-synuclein
-
Béraud, D.; Hathaway, H.A.; Trecki, J.; Chasovskikh, S.; Johnson, D.A.; Johnson, J.A.; Federoff, H.J.; Shimoji, M.; Mhyre, T.R.; Maguire-Zeiss, K.A. Microglial activation and antioxidant responses induced by the Parkinson’s disease protein α-synuclein. J. Neuroimmune Pharmacol. 2013, 8, 94–117.
-
(2013)
J. Neuroimmune Pharmacol
, vol.8
, pp. 94-117
-
-
Béraud, D.1
Hathaway, H.A.2
Trecki, J.3
Chasovskikh, S.4
Johnson, D.A.5
Johnson, J.A.6
Federoff, H.J.7
Shimoji, M.8
Mhyre, T.R.9
Maguire-Zeiss, K.A.10
-
84
-
-
80052473816
-
Toll-like receptor 4 promotes α-synuclein clearance and survival of nigral dopaminergic neurons
-
Stefanova, N.; Fellner, L.; Reindl, M.; Masliah, E.; Poewe, W.; Wenning, G.K. Toll-like receptor 4 promotes α-synuclein clearance and survival of nigral dopaminergic neurons. Am. J. Pathol. 2011, 179, 954–963.
-
(2011)
Am. J. Pathol
, vol.179
, pp. 954-963
-
-
Stefanova, N.1
Fellner, L.2
Reindl, M.3
Masliah, E.4
Poewe, W.5
Wenning, G.K.6
-
85
-
-
84875898265
-
Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia
-
Kim, C.; Ho, D.-H.; Suk, J.-E.; You, S.; Michael, S.; Kang, J.; Joong Lee, S.; Masliah, E.; Hwang, D.; Lee, H.-J; et al. Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia. Nat. Commun. 2013, doi:10.1038/ncomms2534.
-
(2013)
Nat. Commun
-
-
Kim, C.1
Ho, D.-H.2
Suk, J.-E.3
You, S.4
Michael, S.5
Kang, J.6
Joong Lee, S.7
Masliah, E.8
Hwang, D.9
Lee, H.-J.10
-
86
-
-
84860219621
-
Activation of the unfolded protein response is an early event in Alzheimer’s and Parkinson’s disease
-
Hoozemans, J.J.M.; van Haastert, E.S.; Nijholt, D.A.T.; Rozemuller, A.J.M.; Scheper, W. Activation of the unfolded protein response is an early event in Alzheimer’s and Parkinson’s disease. Neurodegener. Dis. 2012, 10, 212–215.
-
(2012)
Neurodegener. Dis
, vol.10
, pp. 212-215
-
-
Hoozemans, J.1
Van Haastert, E.S.2
Nijholt, D.3
Rozemuller, A.4
Scheper, W.5
-
87
-
-
84863229691
-
Accumulation of toxic α-synuclein oligomer within endoplasmic reticulum occurs in α-synucleinopathy in vivo
-
Colla, E.; Jensen, P.H.; Pletnikova, O.; Troncoso, J.C.; Glabe, C.; Lee, M.K. Accumulation of toxic α-synuclein oligomer within endoplasmic reticulum occurs in α-synucleinopathy in vivo. J. Neurosci. 2012, 32, 3301–3305.
-
(2012)
J. Neurosci
, vol.32
, pp. 3301-3305
-
-
Colla, E.1
Jensen, P.H.2
Pletnikova, O.3
Troncoso, J.C.4
Glabe, C.5
Lee, M.K.6
-
88
-
-
84863230467
-
Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivo
-
Colla, E.; Coune, P.; Liu, Y.; Pletnikova, O.; Troncoso, J.C.; Schneider, B.L.; Lee, M.K. Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivo. J. Neurosci. 2012, 32, 3306–3320.
-
(2012)
J. Neurosci
, vol.32
, pp. 3306-3320
-
-
Colla, E.1
Coune, P.2
Liu, Y.3
Pletnikova, O.4
Troncoso, J.C.5
Schneider, B.L.6
Lee, M.K.7
-
89
-
-
77949438990
-
Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson’s disease models
-
Su, L.J.; Auluck, P.K.; Outeiro, T.F.; Yeger-Lotem, E.; Kritzer, J.A.; Tardiff, D.F.; Strathearn, K.E.; Liu, F.; Cao, S.; Hamamichi, S; et al. Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson’s disease models. Dis. Model. Mech. 2010, 3, 194–208.
-
(2010)
Dis. Model. Mech.
, vol.3
, pp. 194-208
-
-
Su, L.J.1
Auluck, P.K.2
Outeiro, T.F.3
Yeger-Lotem, E.4
Kritzer, J.A.5
Tardiff, D.F.6
Strathearn, K.E.7
Liu, F.8
Cao, S.9
Hamamichi, S.10
-
90
-
-
84864347798
-
Differential activation of the ER stress factor XBP1 by oligomeric assemblies
-
Castillo-Carranza, D.L.; Zhang, Y.; Guerrero-Muñoz, M.J.; Kayed, R.; Rincon-Limas, D.E.; Fernandez-Funez, P. Differential activation of the ER stress factor XBP1 by oligomeric assemblies. Neurochem. Res. 2012, 37, 1707–1717.
-
(2012)
Neurochem. Res
, vol.37
, pp. 1707-1717
-
-
Castillo-Carranza, D.L.1
Zhang, Y.2
Guerrero-Muñoz, M.J.3
Kayed, R.4
Rincon-Limas, D.E.5
Fernandez-Funez, P.6
-
91
-
-
77952900626
-
α-Synuclein delays endoplasmic reticulum (ER)-to-Golgi transport in mammalian cells by antagonizing ER/Golgi SNAREs
-
Thayanidhi, N.; Helm, J.R.; Nycz, D.C.; Bentley, M.; Liang, Y.; Hay, J.C. α-Synuclein delays endoplasmic reticulum (ER)-to-Golgi transport in mammalian cells by antagonizing ER/Golgi SNAREs. Mol. Biol. Cell 2010, 21, 1850–1863.
-
(2010)
Mol. Biol. Cell
, vol.21
, pp. 1850-1863
-
-
Thayanidhi, N.1
Helm, J.R.2
Nycz, D.C.3
Bentley, M.4
Liang, Y.5
Hay, J.C.6
-
92
-
-
33746533924
-
α-Synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson’s models
-
Cooper, A.A.; Gitler, A.D.; Cashikar, A.; Haynes, C.M.; Kathryn, J.; Bhullar, B.; Liu, K.; Xu, K.; Strathearn, K.E.; Cao, S; et al. α-Synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson’s models. Science 2006, 313, 324–328.
-
(2006)
Science
, vol.313
, pp. 324-328
-
-
Cooper, A.A.1
Gitler, A.D.2
Cashikar, A.3
Haynes, C.M.4
Kathryn, J.5
Bhullar, B.6
Liu, K.7
Xu, K.8
Strathearn, K.E.9
Cao, S.10
-
93
-
-
84879606955
-
α-Synuclein and protein degradation systems: A reciprocal relationship
-
Xilouri, M.; Brekk, O.R.; Stefanis, L. α-Synuclein and protein degradation systems: A reciprocal relationship. Mol. Neurobiol. 2013, 47, 537–551.
-
(2013)
Mol. Neurobiol
, vol.47
, pp. 537-551
-
-
Xilouri, M.1
Brekk, O.R.2
Stefanis, L.3
-
94
-
-
77951976610
-
Cell-produced α-synuclein oligomers are targeted to, and impair, the 26S proteasome
-
Emmanouilidou, E.; Stefanis, L.; Vekrellis, K. Cell-produced α-synuclein oligomers are targeted to, and impair, the 26S proteasome. Neurobiol. Aging 2010, 31, 953–968.
-
(2010)
Neurobiol. Aging
, vol.31
, pp. 953-968
-
-
Emmanouilidou, E.1
Stefanis, L.2
Vekrellis, K.3
-
95
-
-
0038413759
-
Aggregated and monomeric alpha-synuclein bind to the S6’ proteasomal protein and inhibit proteasomal function
-
Snyder, H.; Mensah, K.; Theisler, C.; Lee, J.; Matouschek, A.; Wolozin, B. Aggregated and monomeric alpha-synuclein bind to the S6’ proteasomal protein and inhibit proteasomal function. J. Biol. Chem. 2003, 278, 11753–11759.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 11753-11759
-
-
Snyder, H.1
Mensah, K.2
Theisler, C.3
Lee, J.4
Matouschek, A.5
Wolozin, B.6
-
96
-
-
65849127844
-
Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy
-
Xilouri, M.; Vogiatzi, T.; Vekrellis, K.; Park, D.; Stefanis, L. Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy. PLOS ONE 2009, 4, e5515.
-
(2009)
PLOS ONE
, vol.4
-
-
Xilouri, M.1
Vogiatzi, T.2
Vekrellis, K.3
Park, D.4
Stefanis, L.5
-
97
-
-
4344659685
-
Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy
-
Cuervo, A.M.; Stefanis, L.; Fredenburg, R.; Lansbury, P.T.; Sulzer, D. Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science 2004, 305, 1292–1295.
-
(2004)
Science
, vol.305
, pp. 1292-1295
-
-
Cuervo, A.M.1
Stefanis, L.2
Fredenburg, R.3
Lansbury, P.T.4
Sulzer, D.5
-
98
-
-
38849174979
-
-
Martinez-vicente, M.; Talloczy, Z.; Kaushik, S.; Massey, A.C.; Mazzulli, J.; Mosharov, E.V.; Hodara, R.; Fredenburg, R.; Wu, D.; Follenzi, A.; et al. Dopamine-modified α-synuclein blocks chaperone-mediated autophagy. J. Clin. Investig. 2008, 118, 777–788.
-
(2008)
Follenzi, A.; Et Al. Dopamine-Modified α-synuclein Blocks Chaperone-Mediated Autophagy. J. Clin. Investig.
, vol.118
, pp. 777-788
-
-
Martinez-Vicente, M.1
Talloczy, Z.2
Kaushik, S.3
Massey, A.C.4
Mazzulli, J.5
Mosharov, E.V.6
Hodara, R.7
Fredenburg, R.8
Wu, D.9
-
99
-
-
84860110592
-
Toxic prefibrillar α-synuclein amyloid oligomers adopt a distinctive antiparallel β-sheet structure
-
Celej, M.S.; Sarroukh, R.; Goormaghtigh, E.; Fidelio, G.D.; Ruysschaert, J.-M.; Raussens, V. Toxic prefibrillar α-synuclein amyloid oligomers adopt a distinctive antiparallel β-sheet structure. Biochem. J. 2012, 443, 719–726.
-
(2012)
Biochem. J
, vol.443
, pp. 719-726
-
-
Celej, M.S.1
Sarroukh, R.2
Goormaghtigh, E.3
Fidelio, G.D.4
Ruysschaert, J.-M.5
Raussens, V.6
-
100
-
-
84862701723
-
Fibrillar α-synuclein and huntingtin exon 1 assemblies are toxic to the cells
-
Pieri, L.; Madiona, K.; Bousset, L.; Melki, R. Fibrillar α-synuclein and huntingtin exon 1 assemblies are toxic to the cells. Biophys. J. 2012, 102, 2894–2905.
-
(2012)
Biophys. J
, vol.102
, pp. 2894-2905
-
-
Pieri, L.1
Madiona, K.2
Bousset, L.3
Melki, R.4
-
101
-
-
69149089854
-
Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synuclein
-
Desplats, P.; Lee, H.; Bae, E.; Patrick, C.; Rockenstein, E.; Crews, L.; Spencer, B.; Masliah, E; Lee, S. Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synuclein. PNAS 2009, 106, 13010–13015.
-
(2009)
PNAS
, vol.106
, pp. 13010-13015
-
-
Desplats, P.1
Lee, H.2
Bae, E.3
Patrick, C.4
Rockenstein, E.5
Crews, L.6
Spencer, B.7
Masliah, E.8
Lee, S.9
-
102
-
-
79551519276
-
α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells
-
Hansen, C.; Angot, E.; Bergström, A.; Steiner, J.A.; Pieri, L.; Paul, G.; Outeiro, T.F.; Melki, R.; Kallunki, P.; Fog, K. α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells. J. Clin. Investig. 2011, 121, 715–725.
-
(2011)
J. Clin. Investig
, vol.121
, pp. 715-725
-
-
Hansen, C.1
Angot, E.2
Bergström, A.3
Steiner, J.A.4
Pieri, L.5
Paul, G.6
Outeiro, T.F.7
Melki, R.8
Kallunki, P.9
Fog, K.10
-
103
-
-
80053613574
-
Exogenous α-synuclein fibrils induce Lewy Body pathology leading to synaptic dysfunction and neuron death
-
Volpicelli-Daley, L.A.; Luk, K.C.; Patel, T.P.; Tanik, S.A.; Dawn, M.; Stieber, A.; Meany, D.F; Trojanowski, J.Q.; Lee, V.M. Exogenous α-synuclein fibrils induce Lewy Body pathology leading to synaptic dysfunction and neuron death. Neuron 2012, 72, 57–71.
-
(2012)
Neuron
, vol.72
, pp. 57-71
-
-
Volpicelli-Daley, L.A.1
Luk, K.C.2
Patel, T.P.3
Tanik, S.A.4
Dawn, M.5
Stieber, A.6
Meany, D.F.7
Trojanowski, J.Q.8
Lee, V.M.9
-
104
-
-
84878230429
-
Lewy body-like α-synuclein aggregates resist degradation and impair macroautophagy
-
Tanik, S.A.; Schultheiss, C.E.; Volpicelli-Daley, L.A.; Brunden, K.R.; Lee, V.M.Y. Lewy body-like α-synuclein aggregates resist degradation and impair macroautophagy. J. Biol. Chem. 2013, 288, 15194–15210.
-
(2013)
J. Biol. Chem
, vol.288
, pp. 15194-15210
-
-
Tanik, S.A.1
Schultheiss, C.E.2
Volpicelli-Daley, L.A.3
Brunden, K.R.4
Lee, V.5
-
105
-
-
79953133327
-
Abeta42 neurotoxicity is mediated by ongoing nucleated polymerization process rather than by discrete Abeta42 species
-
Jan, A.; Adolfsson, O.; Allaman, I.; Buccarello, A.-L.; Magistretti, P.J.; Pfeifer, A.; Muhs, A.; Lashuel, H.A. Abeta42 neurotoxicity is mediated by ongoing nucleated polymerization process rather than by discrete Abeta42 species. J. Biol. Chem. 2011, 286, 8585–8596.
-
(2011)
J. Biol. Chem
, vol.286
, pp. 8585-8596
-
-
Jan, A.1
Adolfsson, O.2
Allaman, I.3
Buccarello, A.-L.4
Magistretti, P.J.5
Pfeifer, A.6
Muhs, A.7
Lashuel, H.A.8
-
106
-
-
84862188904
-
The role of alpha-synuclein oligomerization and aggregation in cellular and animal models of Parkinson’s disease
-
Wan, O.W.; Chung, K.K.K. The role of alpha-synuclein oligomerization and aggregation in cellular and animal models of Parkinson’s disease. PLOS ONE 2012, 7, e38545.
-
(2012)
PLOS ONE
, vol.7
, pp. 38545
-
-
Wan, O.W.1
Chung, K.2
-
107
-
-
23444455247
-
Dopamine promotes α-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway
-
Cherny, R.A.; Culvenor, J.G.; Bottomley, S.P.; Masters, C.L. Dopamine promotes α-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway. FASEB J. 2005, 19, 1377–1379.
-
(2005)
FASEB J
, vol.19
, pp. 1377-1379
-
-
Cherny, R.A.1
Culvenor, J.G.2
Bottomley, S.P.3
Masters, C.L.4
-
108
-
-
7544245555
-
Islet amyloid polypeptide-induced membrane leakage involves uptake of lipids by forming amyloid fibers
-
Sparr, E.; Engel, M.F.M.; Sakharov, D.V.; Sprong, M.; Jacobs, J.; de Kruijff, B.; Höppener, J.W.M.; Killian, J.A. Islet amyloid polypeptide-induced membrane leakage involves uptake of lipids by forming amyloid fibers. FEBS Lett. 2004, 577, 117–120.
-
(2004)
FEBS Lett
, vol.577
, pp. 117-120
-
-
Sparr, E.1
Engel, M.2
Sakharov, D.V.3
Sprong, M.4
Jacobs, J.5
De Kruijff, B.6
Höppener, J.7
Killian, J.A.8
-
109
-
-
0033669319
-
In situ and in vitro study of colocalization and segregation of alpha-synuclein, ubiquitin, and lipids in Lewy bodies
-
Gai, W.; Yuan, H.; Li, X.; Power, J.; Blumbergs, P.; Jensen, P. In situ and in vitro study of colocalization and segregation of alpha-synuclein, ubiquitin, and lipids in Lewy bodies. Exp. Neurol. 2000, 166, 324–333.
-
(2000)
Exp. Neurol
, vol.166
, pp. 324-333
-
-
Gai, W.1
Yuan, H.2
Li, X.3
Power, J.4
Blumbergs, P.5
Jensen, P.6
-
110
-
-
82555170657
-
Mechanism of membrane interaction and disruption by α-synuclein
-
Reynolds, N.P.; Soragni, A.; Rabe, M.; Verdes, D.; Liverani, E.; Handschin, S.; Riek, R.; Seeger, S. Mechanism of membrane interaction and disruption by α-synuclein. J. Am. Chem. Soc. 2011, 133, 19366–19375.
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 19366-19375
-
-
Reynolds, N.P.1
Soragni, A.2
Rabe, M.3
Verdes, D.4
Liverani, E.5
Handschin, S.6
Riek, R.7
Seeger, S.8
-
111
-
-
84867525379
-
Radiating amyloid fibril formation on the surface of lipid membranes through unit-assembly of oligomeric species of α-synuclein
-
Lee, J.-H.; Hong, C.-S.; Lee, S.; Yang, J.-E.; Park, Y.I.; Lee, D.; Hyeon, T.; Jung, S.; Paik, S.R. Radiating amyloid fibril formation on the surface of lipid membranes through unit-assembly of oligomeric species of α-synuclein. PLOS ONE 2012, 7, e47580.
-
(2012)
PLOS ONE
, vol.7
-
-
Lee, J.-H.1
Hong, C.-S.2
Lee, S.3
Yang, J.-E.4
Park, Y.I.5
Lee, D.6
Hyeon, T.7
Jung, S.8
Paik, S.R.9
-
112
-
-
84910664562
-
Membrane interactions and fibrillization of α-synuclein play an essential role in membrane disruption
-
Chaudhary, H.; Stefanovic, A.N.D.; Subramaniam, V.; Claessens, M.M.A.E. Membrane interactions and fibrillization of α-synuclein play an essential role in membrane disruption. FEBS Lett. 2014, 588, 4457–4463.
-
(2014)
FEBS Lett
, vol.588
, pp. 4457-4463
-
-
Chaudhary, H.1
Stefanovic, A.2
Subramaniam, V.3
Claessens, M.4
-
113
-
-
84898665782
-
Biophysical groundwork as a hinge to unravel the biology of α-synuclein aggregation and toxicity
-
Plotegher, N.; Greggio, E.; Bisaglia, M.; Bubacco, L. Biophysical groundwork as a hinge to unravel the biology of α-synuclein aggregation and toxicity. Q. Rev. Biophys. 2014, 47, 1–48.
-
(2014)
Q. Rev. Biophys.
, vol.47
, pp. 1-48
-
-
Plotegher, N.1
Greggio, E.2
Bisaglia, M.3
Bubacco, L.4
-
114
-
-
77952648551
-
Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival
-
Emmanouilidou, E.; Melachroinou, K.; Roumeliotis, T.; Garbis, S.D.; Ntzouni, M.; Margaritis, L.H.; Stefanis, L.; Vekrellis, K. Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival. J. Neurosci. 2010, 30, 6838–6851.
-
(2010)
J. Neurosci
, vol.30
, pp. 6838-6851
-
-
Emmanouilidou, E.1
Melachroinou, K.2
Roumeliotis, T.3
Garbis, S.D.4
Ntzouni, M.5
Margaritis, L.H.6
Stefanis, L.7
Vekrellis, K.8
-
115
-
-
79952742454
-
In vivo demonstration that α-synuclein oligomers are toxic
-
Winner, B.; Jappelli, R.; Maji, S.K.; Desplats, P.A.; Boyer, L.; Aigner, S. In vivo demonstration that α-synuclein oligomers are toxic. PNAS 2011, 108, 4194–4199.
-
(2011)
PNAS
, vol.108
, pp. 4194-4199
-
-
Winner, B.1
Jappelli, R.2
Maji, S.K.3
Desplats, P.A.4
Boyer, L.5
Aigner, S.6
-
116
-
-
84899889312
-
Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo
-
Rockenstein, E.; Nuber, S.; Overk, C.R.; Ubhi, K.; Mante, M.; Patrick, C.; Adame, A.; Trejo-Morales, M.; Gerez, J.; Picotti, P; et al. Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo. Brain 2014, 137, 1496–1513.
-
(2014)
Brain
, vol.137
, pp. 1496-1513
-
-
Rockenstein, E.1
Nuber, S.2
Overk, C.R.3
Ubhi, K.4
Mante, M.5
Patrick, C.6
Adame, A.7
Trejo-Morales, M.8
Gerez, J.9
Picotti, P.10
-
117
-
-
70350338222
-
Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson’s disease models
-
Karpinar, D.P.; Balija, M.B.G.; Kügler, S.; Opazo, F.; Rezaei-Ghaleh, N.; Wender, N.; Kim, H.-Y.; Taschenberger, G.; Falkenburger, B.H.; Heise, H; et al. Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson’s disease models. EMBO J. 2009, 28, 3256–3268.
-
(2009)
EMBO J
, vol.28
, pp. 3256-3268
-
-
Karpinar, D.P.1
Balija, M.2
Kügler, S.3
Opazo, F.4
Rezaei-Ghaleh, N.5
Wender, N.6
Kim, H.-Y.7
Taschenberger, G.8
Falkenburger, B.H.9
Heise, H.10
-
118
-
-
84862672217
-
Aggregation of αSynuclein promotes progressive in vivo neurotoxicity in adult rat dopaminergic neurons
-
Taschenberger, G.; Garrido, M.; Tereshchenko, Y.; Bähr, M.; Zweckstetter, M.; Kügler, S. Aggregation of αSynuclein promotes progressive in vivo neurotoxicity in adult rat dopaminergic neurons. Acta Neuropathol. 2012, 123, 671–683.
-
(2012)
Acta Neuropathol
, vol.123
, pp. 671-683
-
-
Taschenberger, G.1
Garrido, M.2
Tereshchenko, Y.3
Bähr, M.4
Zweckstetter, M.5
Kügler, S.6
-
119
-
-
84904637112
-
Structure activity relationship of phenolic acid inhibitors of α-synuclein fibril formation and toxicity
-
Ardah, M.T.; Paleologou, K.E.; Lv, G.; Abul Khair, S.B.; Kazim, A.S.; Minhas, S.T.; Al-Tel, T.H.; Al-Hayani, A.A.; Haque, M.E.; Eliezer, D; et al. Structure activity relationship of phenolic acid inhibitors of α-synuclein fibril formation and toxicity. Front. Aging Neurosci. 2014, doi:10.3389/fnagi.2014.00197.
-
(2014)
Front. Aging Neurosci
-
-
Ardah, M.T.1
Paleologou, K.E.2
Lv, G.3
Abul Khair, S.B.4
Kazim, A.S.5
Minhas, S.T.6
Al-Tel, T.H.7
Al-Hayani, A.A.8
Haque, M.E.9
Eliezer, D.10
-
120
-
-
77952346781
-
EGCG remodels mature alpha-synuclein and amyloid-beta fibrils and reduces cellular toxicity
-
Bieschke, J.; Russ, J.; Friedrich, R.P.; Ehrnhoefer, D.E.; Wobst, H.; Neugebauer, K.; Wanker, E.E. EGCG remodels mature alpha-synuclein and amyloid-beta fibrils and reduces cellular toxicity. Proc. Natl. Acad. Sci. USA 2010, 107, 7710–7715.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 7710-7715
-
-
Bieschke, J.1
Russ, J.2
Friedrich, R.P.3
Ehrnhoefer, D.E.4
Wobst, H.5
Neugebauer, K.6
Wanker, E.E.7
-
121
-
-
77953853289
-
Baicalein reduces E46K α-synuclein aggregation in vitro and protects cells against E46K α-synuclein toxicity in cell models of familiar Parkinsonism
-
Li, Q.; Gillardon, F.; Hengerer, B.; Berlinicke, C. Baicalein reduces E46K α-synuclein aggregation in vitro and protects cells against E46K α-synuclein toxicity in cell models of familiar Parkinsonism. J. Neurochem. 2011, 114, 419–429
-
(2011)
J. Neurochem
, vol.114
, pp. 419-429
-
-
Li, Q.1
Gillardon, F.2
Hengerer, B.3
Berlinicke, C.4
|