Aβ42 neurotoxicity is mediated by ongoing nucleated polymerization process rather than by discrete Aβ42 species

Journal of Biological Chemistry

Volumn 286, Issue 10, 2011, Pages 8585-8596

  Jan, Asad ^a   Adolfsson, Oskar ^a   Allaman, Igor ^a   Buccarello, Anna Lucia ^a   Magistretti, Pierre J ^a   Pfeifer, Andrea ^a   Muhs, Andreas ^a   Lashuel, Hilal A ^a  

^a EPFL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; AMYLOID FIBRIL; AMYLOID FORMATION; CELL LINES; FIBRIL FORMATION; FIBRILLIZATION; HETEROGENEOUS MIXTURES; INSULIN-DEGRADING ENZYMES; MORPHOLOGY DISTRIBUTIONS; NEUROTOXICITY; NUCLEATED POLYMERIZATION; PROTOFIBRILS; SELECTIVE REMOVAL; STRUCTURAL BASIS; THERAPEUTIC INTERVENTION;

CELL CULTURE; DISEASE CONTROL; GLYCOPROTEINS; NEURODEGENERATIVE DISEASES; OLIGOMERS; PURIFICATION;

TOXICITY;

AMYLOID BETA PROTEIN[1-42]; AMYLOID; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); PEPTIDE FRAGMENT;

ANIMAL CELL; ARTICLE; BRAIN NERVE CELL; CONTROLLED STUDY; CYTOTOXICITY; FRACTIONATION; HUMAN; HUMAN CELL; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN POLYMERIZATION; PROTEIN PROCESSING; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; RAT; ALZHEIMER DISEASE; ANIMAL; CELL STRAIN; CHEMISTRY; GENETICS; METABOLISM; NERVE CELL; PROTEIN MULTIMERIZATION; PROTEIN QUATERNARY STRUCTURE; SPRAGUE DAWLEY RAT;

ALZHEIMER DISEASE; AMYLOID; AMYLOID BETA-PEPTIDES; ANIMALS; HUMANS; NEURONS; PC12 CELLS; PEPTIDE FRAGMENTS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; RATS; RATS, SPRAGUE-DAWLEY;

EID: 79953133327     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.172411     Document Type: Article

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