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Volumn 5, Issue 4, 2015, Pages 2723-2757

The role of the transcriptional regulation of stromal cells in chronic inflammation

Author keywords

AP 1; Arthritis; Cancer; Fibroblast; HIF 1 ; Inflammation; NF B; STAT; Stroma; Transcription

Indexed keywords

BETA INTERFERON; CXCL1 CHEMOKINE; CXCL11 CHEMOKINE; CXCL2 CHEMOKINE; CXCL9 CHEMOKINE; CYCLOOXYGENASE 2; GAMMA INTERFERON INDUCIBLE PROTEIN 10; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; INTERSTITIAL COLLAGENASE; JANUS KINASE; MACROPHAGE INFLAMMATORY PROTEIN 2; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MATRIX METALLOPROTEINASE; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; PATTERN RECOGNITION RECEPTOR; PROTEIN BCL 2; RANTES; REACTIVE OXYGEN METABOLITE; STAT3 PROTEIN; STROMAL CELL DERIVED FACTOR 1; STROMELYSIN; TOLL LIKE RECEPTOR 3; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG;

EID: 85012053622     PISSN: None     EISSN: 2218273X     Source Type: Journal    
DOI: 10.3390/biom5042723     Document Type: Review
Times cited : (12)

References (209)
  • 1
    • 34147190086 scopus 로고    scopus 로고
    • Chronic inflammation: A failure of resolution?
    • Lawrence, T.; Gilroy, D.W. Chronic inflammation: A failure of resolution? Int. J. Exp. Pathol. 2007, 88, 85-94.
    • (2007) Int. J. Exp. Pathol. , vol.88 , pp. 85-94
    • Lawrence, T.1    Gilroy, D.W.2
  • 2
    • 84862153001 scopus 로고    scopus 로고
    • New insights into chronic inflammation-induced immunosuppression
    • Kanterman, J.; Sade-Feldman, M.; Baniyash, M. New insights into chronic inflammation-induced immunosuppression. Semin. Cancer Biol. 2012, 22, 307-318.
    • (2012) Semin. Cancer Biol. , vol.22 , pp. 307-318
    • Kanterman, J.1    Sade-Feldman, M.2    Baniyash, M.3
  • 4
    • 84881030156 scopus 로고    scopus 로고
    • "Cancer associated fibroblasts"-More than meets the eye
    • Madar, S.; Goldstein, I.; Rotter, V. "Cancer associated fibroblasts"-More than meets the eye. Trends Mol. Med. 2013, 19, 447-453.
    • (2013) Trends Mol. Med. , vol.19 , pp. 447-453
    • Madar, S.1    Goldstein, I.2    Rotter, V.3
  • 7
    • 0031975384 scopus 로고    scopus 로고
    • Paracrine/autocrine regulation of breast cancer by the insulin-like growth factors
    • Rasmussen, A.A.; Cullen, K.J. Paracrine/autocrine regulation of breast cancer by the insulin-like growth factors. Breast Cancer Res. Treat. 1998, 47, 219-233.
    • (1998) Breast Cancer Res. Treat. , vol.47 , pp. 219-233
    • Rasmussen, A.A.1    Cullen, K.J.2
  • 10
    • 79952724783 scopus 로고    scopus 로고
    • Intratumor T helper type 2 cell infiltrate correlates with cancer-associated fibroblast thymic stromal lymphopoietin production and reduced survival in pancreatic cancer
    • De Monte, L.; Reni, M.; Tassi, E.; Clavenna, D.; Papa, I.; Recalde, H.; Braga, M.; di Carlo, V.; Doglioni, C.; Protti, M.P. Intratumor T helper type 2 cell infiltrate correlates with cancer-associated fibroblast thymic stromal lymphopoietin production and reduced survival in pancreatic cancer. J. Exp. Med. 2011, 208, 469-478.
    • (2011) J. Exp. Med. , vol.208 , pp. 469-478
    • De Monte, L.1    Reni, M.2    Tassi, E.3    Clavenna, D.4    Papa, I.5    Recalde, H.6    Braga, M.7    di Carlo, V.8    Doglioni, C.9    Protti, M.P.10
  • 11
    • 76349096670 scopus 로고    scopus 로고
    • Cancer-associated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-κB-dependent manner
    • Erez, N.; Truitt, M.; Olson, P.; Arron, S.T.; Hanahan, D. Cancer-associated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-κB-dependent manner. Cancer Cell. 2010, 17, 135-147.
    • (2010) Cancer Cell. , vol.17 , pp. 135-147
    • Erez, N.1    Truitt, M.2    Olson, P.3    Arron, S.T.4    Hanahan, D.5
  • 13
    • 80051525374 scopus 로고    scopus 로고
    • Interleukin 1α sustains the expression of inflammatory factors in human pancreatic cancer microenvironment by targeting cancer-associated fibroblasts
    • Tjomsland, V.; Spangeus, A.; Valila, J.; Sandstrom, P.; Borch, K.; Druid, H.; Falkmer, S.; Falkmer, U.; Messmer, D.; Larsson, M. Interleukin 1α sustains the expression of inflammatory factors in human pancreatic cancer microenvironment by targeting cancer-associated fibroblasts. Neoplasia 2011, 13, 664-675.
    • (2011) Neoplasia , vol.13 , pp. 664-675
    • Tjomsland, V.1    Spangeus, A.2    Valila, J.3    Sandstrom, P.4    Borch, K.5    Druid, H.6    Falkmer, S.7    Falkmer, U.8    Messmer, D.9    Larsson, M.10
  • 14
    • 0029855587 scopus 로고    scopus 로고
    • Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice
    • Muller-Ladner, U.; Kriegsmann, J.; Franklin, B.N.; Matsumoto, S.; Geiler, T.; Gay, R.E.; Gay, S. Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice. Am. J. Pathol. 1996, 149, 1607-1615.
    • (1996) Am. J. Pathol. , vol.149 , pp. 1607-1615
    • Muller-Ladner, U.1    Kriegsmann, J.2    Franklin, B.N.3    Matsumoto, S.4    Geiler, T.5    Gay, R.E.6    Gay, S.7
  • 15
  • 16
    • 70349774436 scopus 로고    scopus 로고
    • Human inflammatory synovial fibroblasts induce enhanced myeloid cell recruitment and angiogenesis through a hypoxia-inducible transcription factor 1α/vascular endothelial growth factor-mediated pathway in immunodeficient mice
    • Del Rey, M.J.; Izquierdo, E.; Caja, S.; Usategui, A.; Santiago, B.; Galindo, M.; Pablos, J.L. Human inflammatory synovial fibroblasts induce enhanced myeloid cell recruitment and angiogenesis through a hypoxia-inducible transcription factor 1α/vascular endothelial growth factor-mediated pathway in immunodeficient mice. Arthritis Rheum. 2009, 60, 2926-2934.
    • (2009) Arthritis Rheum. , vol.60 , pp. 2926-2934
    • Del Rey, M.J.1    Izquierdo, E.2    Caja, S.3    Usategui, A.4    Santiago, B.5    Galindo, M.6    Pablos, J.L.7
  • 17
    • 67650766977 scopus 로고    scopus 로고
    • Translating molecular insights in autoimmunity into effective therapy
    • Feldmann, M. Translating molecular insights in autoimmunity into effective therapy. Annu. Rev. Immunol. 2009, 27, 1-27.
    • (2009) Annu. Rev. Immunol. , vol.27 , pp. 1-27
    • Feldmann, M.1
  • 19
    • 73249125200 scopus 로고    scopus 로고
    • Fibroblast-like synoviocytes: Key effector cells in rheumatoid arthritis
    • Bartok, B.; Firestein, G.S. Fibroblast-like synoviocytes: Key effector cells in rheumatoid arthritis. Immunol. Rev. 2010, 233, 233-255.
    • (2010) Immunol. Rev. , vol.233 , pp. 233-255
    • Bartok, B.1    Firestein, G.S.2
  • 22
    • 18844428327 scopus 로고    scopus 로고
    • Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
    • Orimo, A.; Gupta, P.B.; Sgroi, D.C.; Arenzana-Seisdedos, F.; Delaunay, T.; Naeem, R.; Carey, V.J.; Richardson, A.L.; Weinberg, R.A. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 2005, 121, 335-348.
    • (2005) Cell , vol.121 , pp. 335-348
    • Orimo, A.1    Gupta, P.B.2    Sgroi, D.C.3    Arenzana-Seisdedos, F.4    Delaunay, T.5    Naeem, R.6    Carey, V.J.7    Richardson, A.L.8    Weinberg, R.A.9
  • 23
    • 84881027752 scopus 로고    scopus 로고
    • The tumor microenvironment contribution to development, growth, invasion and metastasis of head and neck squamous cell carcinomas
    • Koontongkaew, S. The tumor microenvironment contribution to development, growth, invasion and metastasis of head and neck squamous cell carcinomas. J. Cancer 2013, 4, 66-83.
    • (2013) J. Cancer , vol.4 , pp. 66-83
    • Koontongkaew, S.1
  • 24
    • 77549083560 scopus 로고    scopus 로고
    • Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer
    • Grivennikov, S.I.; Karin, M. Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer. Cytokine Growth Factor Rev. 2010, 21, 11-19.
    • (2010) Cytokine Growth Factor Rev. , vol.21 , pp. 11-19
    • Grivennikov, S.I.1    Karin, M.2
  • 25
    • 77950346282 scopus 로고    scopus 로고
    • Immunity, inflammation, and cancer
    • Grivennikov, S.I.; Greten, F.R.; Karin, M. Immunity, inflammation, and cancer. Cell 2010, 140, 883-899.
    • (2010) Cell , vol.140 , pp. 883-899
    • Grivennikov, S.I.1    Greten, F.R.2    Karin, M.3
  • 26
    • 84875721405 scopus 로고    scopus 로고
    • Tumor necrosis factor α induces sustained signaling and a prolonged and unremitting inflammatory response in rheumatoid arthritis synovial fibroblasts
    • Lee, A.; Qiao, Y.; Grigoriev, G.; Chen, J.; Park-Min, K.H.; Park, S.H.; Ivashkiv, L.B.; Kalliolias, G.D. Tumor necrosis factor α induces sustained signaling and a prolonged and unremitting inflammatory response in rheumatoid arthritis synovial fibroblasts. Arthritis Rheum. 2013, 65, 928-938.
    • (2013) Arthritis Rheum. , vol.65 , pp. 928-938
    • Lee, A.1    Qiao, Y.2    Grigoriev, G.3    Chen, J.4    Park-Min, K.H.5    Park, S.H.6    Ivashkiv, L.B.7    Kalliolias, G.D.8
  • 27
    • 67349162130 scopus 로고    scopus 로고
    • Tumour necrosis factor and cancer
    • Balkwill, F. Tumour necrosis factor and cancer. Nat. Rev. Cancer 2009, 9, 361-371.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 361-371
    • Balkwill, F.1
  • 28
    • 73849090217 scopus 로고    scopus 로고
    • Ikk/NF-κB and STAT3 pathways: Central signalling hubs in inflammation-mediated tumour promotion and metastasis
    • Bollrath, J.; Greten, F.R. Ikk/NF-κB and STAT3 pathways: Central signalling hubs in inflammation-mediated tumour promotion and metastasis. EMBO Rep. 2009, 10, 1314-1319.
    • (2009) EMBO Rep. , vol.10 , pp. 1314-1319
    • Bollrath, J.1    Greten, F.R.2
  • 29
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflammation and immunity: A leading role for STAT3
    • Yu, H.; Pardoll, D.; Jove, R. STATs in cancer inflammation and immunity: A leading role for STAT3. Nat. Rev. Cancer 2009, 9, 798-809.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 798-809
    • Yu, H.1    Pardoll, D.2    Jove, R.3
  • 30
    • 0036234459 scopus 로고    scopus 로고
    • Missing pieces in the NF-κB puzzle
    • Ghosh, S.; Karin, M. Missing pieces in the NF-κB puzzle. Cell 2002, 109, S81-S96.
    • (2002) Cell , vol.109 , pp. S81-S96
    • Ghosh, S.1    Karin, M.2
  • 31
    • 0034650925 scopus 로고    scopus 로고
    • The angiogenic factor interleukin 8 is induced in non-small cell lung cancer/pulmonary fibroblast cocultures
    • Anderson, I.C.; Mari, S.E.; Broderick, R.J.; Mari, B.P.; Shipp, M.A. The angiogenic factor interleukin 8 is induced in non-small cell lung cancer/pulmonary fibroblast cocultures. Cancer Res. 2000, 60, 269-272.
    • (2000) Cancer Res. , vol.60 , pp. 269-272
    • Anderson, I.C.1    Mari, S.E.2    Broderick, R.J.3    Mari, B.P.4    Shipp, M.A.5
  • 32
    • 4944265244 scopus 로고    scopus 로고
    • Gene expression profiling of tumor-stromal interactions between pancreatic cancer cells and stromal fibroblasts
    • Sato, N.; Maehara, N.; Goggins, M. Gene expression profiling of tumor-stromal interactions between pancreatic cancer cells and stromal fibroblasts. Cancer Res. 2004, 64, 6950-6956.
    • (2004) Cancer Res. , vol.64 , pp. 6950-6956
    • Sato, N.1    Maehara, N.2    Goggins, M.3
  • 34
    • 0033215242 scopus 로고    scopus 로고
    • Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium
    • Olumi, A.F.; Grossfeld, G.D.; Hayward, S.W.; Carroll, P.R.; Tlsty, T.D.; Cunha, G.R. Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium. Cancer Res. 1999, 59, 5002-5011.
    • (1999) Cancer Res. , vol.59 , pp. 5002-5011
    • Olumi, A.F.1    Grossfeld, G.D.2    Hayward, S.W.3    Carroll, P.R.4    Tlsty, T.D.5    Cunha, G.R.6
  • 35
    • 38849202330 scopus 로고    scopus 로고
    • Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting
    • Pietras, K.; Pahler, J.; Bergers, G.; Hanahan, D. Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting. PLoS Med. 2008, 5, e19.
    • (2008) PLoS Med. , vol.5
    • Pietras, K.1    Pahler, J.2    Bergers, G.3    Hanahan, D.4
  • 36
    • 0030044619 scopus 로고    scopus 로고
    • Activation of transcription factor NF-κB in human synovial cells in response to tumor necrosis factor α
    • Fujisawa, K.; Aono, H.; Hasunuma, T.; Yamamoto, K.; Mita, S.; Nishioka, K. Activation of transcription factor NF-κB in human synovial cells in response to tumor necrosis factor α. Arthritis Rheum. 1996, 39, 197-203.
    • (1996) Arthritis Rheum. , vol.39 , pp. 197-203
    • Fujisawa, K.1    Aono, H.2    Hasunuma, T.3    Yamamoto, K.4    Mita, S.5    Nishioka, K.6
  • 37
    • 0031744967 scopus 로고    scopus 로고
    • Analysis of the NF-κB p65 subunit, Fas antigen, Fas ligand and Bcl-2-related proteins in the synovium of RA and polyarticular JRA
    • Sioud, M.; Mellbye, O.; Forre, O. Analysis of the NF-κB p65 subunit, Fas antigen, Fas ligand and Bcl-2-related proteins in the synovium of RA and polyarticular JRA. Clin. Exp. Rheumatol. 1998, 16, 125-134.
    • (1998) Clin. Exp. Rheumatol. , vol.16 , pp. 125-134
    • Sioud, M.1    Mellbye, O.2    Forre, O.3
  • 38
    • 2642517290 scopus 로고    scopus 로고
    • Increased synovial tissue NF-κB1 expression at sites adjacent to the cartilage-pannus junction in rheumatoid arthritis
    • Benito, M.J.; Murphy, E.; Murphy, E.P.; van den Berg, W.B.; FitzGerald, O.; Bresnihan, B. Increased synovial tissue NF-κB1 expression at sites adjacent to the cartilage-pannus junction in rheumatoid arthritis. Arthritis Rheum. 2004, 50, 1781-1787.
    • (2004) Arthritis Rheum. , vol.50 , pp. 1781-1787
    • Benito, M.J.1    Murphy, E.2    Murphy, E.P.3    van den Berg, W.B.4    FitzGerald, O.5    Bresnihan, B.6
  • 40
    • 0032428729 scopus 로고    scopus 로고
    • AP-1 and NF-κB regulation in rheumatoid arthritis and murine collagen-induced arthritis
    • Han, Z.; Boyle, D.L.; Manning, A.M.; Firestein, G.S. AP-1 and NF-κB regulation in rheumatoid arthritis and murine collagen-induced arthritis. Autoimmunity 1998, 28, 197-208.
    • (1998) Autoimmunity , vol.28 , pp. 197-208
    • Han, Z.1    Boyle, D.L.2    Manning, A.M.3    Firestein, G.S.4
  • 41
    • 0038575364 scopus 로고    scopus 로고
    • Heterogeneous requirement of IκB kinase 2 for inflammatory cytokine and matrix metalloproteinase production in rheumatoid arthritis: Implications for therapy
    • Andreakos, E.; Smith, C.; Kiriakidis, S.; Monaco, C.; de Martin, R.; Brennan, F.M.; Paleolog, E.; Feldmann, M.; Foxwell, B.M. Heterogeneous requirement of IκB kinase 2 for inflammatory cytokine and matrix metalloproteinase production in rheumatoid arthritis: Implications for therapy. Arthritis Rheum. 2003, 48, 1901-1912.
    • (2003) Arthritis Rheum. , vol.48 , pp. 1901-1912
    • Andreakos, E.1    Smith, C.2    Kiriakidis, S.3    Monaco, C.4    de Martin, R.5    Brennan, F.M.6    Paleolog, E.7    Feldmann, M.8    Foxwell, B.M.9
  • 42
    • 39549089300 scopus 로고    scopus 로고
    • Mesenchymal cell targeting by tnf as a common pathogenic principle in chronic inflammatory joint and intestinal diseases
    • Armaka, M.; Apostolaki, M.; Jacques, P.; Kontoyiannis, D.L.; Elewaut, D.; Kollias, G. Mesenchymal cell targeting by tnf as a common pathogenic principle in chronic inflammatory joint and intestinal diseases. J. Exp. Med. 2008, 205, 331-337.
    • (2008) J. Exp. Med. , vol.205 , pp. 331-337
    • Armaka, M.1    Apostolaki, M.2    Jacques, P.3    Kontoyiannis, D.L.4    Elewaut, D.5    Kollias, G.6
  • 43
    • 0031897632 scopus 로고    scopus 로고
    • NF-κB and Rel proteins: Evolutionarily conserved mediators of immune responses
    • Ghosh, S.; May, M.J.; Kopp, E.B. NF-κB and Rel proteins: Evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol. 1998, 16, 225-260.
    • (1998) Annu. Rev. Immunol. , vol.16 , pp. 225-260
    • Ghosh, S.1    May, M.J.2    Kopp, E.B.3
  • 44
    • 0028817585 scopus 로고
    • Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of relB, a member of the NF-κB/Rel family
    • Weih, F.; Carrasco, D.; Durham, S.K.; Barton, D.S.; Rizzo, C.A.; Ryseck, R.P.; Lira, S.A.; Bravo, R. Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of relB, a member of the NF-κB/Rel family. Cell 1995, 80, 331-340.
    • (1995) Cell , vol.80 , pp. 331-340
    • Weih, F.1    Carrasco, D.2    Durham, S.K.3    Barton, D.S.4    Rizzo, C.A.5    Ryseck, R.P.6    Lira, S.A.7    Bravo, R.8
  • 46
    • 21644449560 scopus 로고    scopus 로고
    • The TRAF6-Nfκb signaling pathway in autoimmunity: Not just inflammation
    • Thomas, R. The TRAF6-Nfκb signaling pathway in autoimmunity: Not just inflammation. Arthritis Res. Ther. 2005, 7, 170-173.
    • (2005) Arthritis Res. Ther. , vol.7 , pp. 170-173
    • Thomas, R.1
  • 47
    • 67650724069 scopus 로고    scopus 로고
    • Regulation and function of NF-κB transcription factors in the immune system
    • Vallabhapurapu, S.; Karin, M. Regulation and function of NF-κB transcription factors in the immune system. Annu. Rev. Immunol. 2009, 27, 693-733.
    • (2009) Annu. Rev. Immunol. , vol.27 , pp. 693-733
    • Vallabhapurapu, S.1    Karin, M.2
  • 48
    • 21344435775 scopus 로고    scopus 로고
    • Mechanisms of disease: Insights into the emerging role of signal transducers and activators of transcription in cancer
    • Haura, E.B.; Turkson, J.; Jove, R. Mechanisms of disease: Insights into the emerging role of signal transducers and activators of transcription in cancer. Nat. Clin. Pract. Oncol. 2005, 2, 315-324.
    • (2005) Nat. Clin. Pract. Oncol. , vol.2 , pp. 315-324
    • Haura, E.B.1    Turkson, J.2    Jove, R.3
  • 50
    • 67650495415 scopus 로고    scopus 로고
    • IL-17 can promote tumor growth through an IL-6-STAT3 signaling pathway
    • Wang, L.; Yi, T.; Kortylewski, M.; Pardoll, D.M.; Zeng, D.; Yu, H. IL-17 can promote tumor growth through an IL-6-STAT3 signaling pathway. J. Exp. Med. 2009, 206, 1457-1464.
    • (2009) J. Exp. Med. , vol.206 , pp. 1457-1464
    • Wang, L.1    Yi, T.2    Kortylewski, M.3    Pardoll, D.M.4    Zeng, D.5    Yu, H.6
  • 54
    • 66449127943 scopus 로고    scopus 로고
    • Cross talk initiated by endothelial cells enhances migration and inhibits anoikis of squamous cell carcinoma cells through STAT3/AKT/ERK signaling
    • Neiva, K.G.; Zhang, Z.; Miyazawa, M.; Warner, K.A.; Karl, E.; Nor, J.E. Cross talk initiated by endothelial cells enhances migration and inhibits anoikis of squamous cell carcinoma cells through STAT3/AKT/ERK signaling. Neoplasia 2009, 11, 583-593.
    • (2009) Neoplasia , vol.11 , pp. 583-593
    • Neiva, K.G.1    Zhang, Z.2    Miyazawa, M.3    Warner, K.A.4    Karl, E.5    Nor, J.E.6
  • 58
    • 33745859743 scopus 로고    scopus 로고
    • The BRAF-MAPK signaling pathway is essential for cancer-immune evasion in human melanoma cells
    • Sumimoto, H.; Imabayashi, F.; Iwata, T.; Kawakami, Y. The BRAF-MAPK signaling pathway is essential for cancer-immune evasion in human melanoma cells. J. Exp. Med. 2006, 203, 1651-1656.
    • (2006) J. Exp. Med. , vol.203 , pp. 1651-1656
    • Sumimoto, H.1    Imabayashi, F.2    Iwata, T.3    Kawakami, Y.4
  • 60
    • 0032168152 scopus 로고    scopus 로고
    • Interleukin-6-type cytokine signalling through the gp130/JAK/STAT pathway
    • Heinrich, P.C.; Behrmann, I.; Muller-Newen, G.; Schaper, F.; Graeve, L. Interleukin-6-type cytokine signalling through the gp130/JAK/STAT pathway. Biochem. J. 1998, 334, 297-314.
    • (1998) Biochem. J. , vol.334 , pp. 297-314
    • Heinrich, P.C.1    Behrmann, I.2    Muller-Newen, G.3    Schaper, F.4    Graeve, L.5
  • 65
    • 79957610938 scopus 로고    scopus 로고
    • The outs and the INS of sphingosine-1-phosphate in immunity
    • Spiegel, S.; Milstien, S. The outs and the INS of sphingosine-1-phosphate in immunity. Nat. Rev. Immunol. 2011, 11, 403-415.
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 403-415
    • Spiegel, S.1    Milstien, S.2
  • 67
    • 80052358980 scopus 로고    scopus 로고
    • Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling
    • Jones, S.A.; Scheller, J.; Rose-John, S. Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling. J. Clin. Investig. 2011, 121, 3375-3383.
    • (2011) J. Clin. Investig. , vol.121 , pp. 3375-3383
    • Jones, S.A.1    Scheller, J.2    Rose-John, S.3
  • 69
    • 3342892420 scopus 로고    scopus 로고
    • Inhibition of IL-6 for the treatment of inflammatory diseases
    • Nishimoto, N.; Kishimoto, T. Inhibition of IL-6 for the treatment of inflammatory diseases. Curr. Opin. Pharmacol. 2004, 4, 386-391.
    • (2004) Curr. Opin. Pharmacol. , vol.4 , pp. 386-391
    • Nishimoto, N.1    Kishimoto, T.2
  • 70
    • 24744435772 scopus 로고    scopus 로고
    • Directing transition from innate to acquired immunity: Defining a role for IL-6
    • Jones, S.A. Directing transition from innate to acquired immunity: Defining a role for IL-6. J. Immunol. 2005, 175, 3463-3468.
    • (2005) J. Immunol. , vol.175 , pp. 3463-3468
    • Jones, S.A.1
  • 71
    • 0032169769 scopus 로고    scopus 로고
    • A possible role for soluble IL-6 receptor in the pathogenesis of systemic onset juvenile chronic arthritis
    • Keul, R.; Heinrich, P.C.; Muller-newen, G.; Muller, K.; Woo, P. A possible role for soluble IL-6 receptor in the pathogenesis of systemic onset juvenile chronic arthritis. Cytokine 1998, 10, 729-734.
    • (1998) Cytokine , vol.10 , pp. 729-734
    • Keul, R.1    Heinrich, P.C.2    Muller-Newen, G.3    Muller, K.4    Woo, P.5
  • 73
    • 84878806248 scopus 로고    scopus 로고
    • Biologic therapy in rheumatoid arthritis
    • Canete, J.D.; Pablos, J.L. Biologic therapy in rheumatoid arthritis. Curr. Top. Med. Chem. 2013, 13, 752-759.
    • (2013) Curr. Top. Med. Chem. , vol.13 , pp. 752-759
    • Canete, J.D.1    Pablos, J.L.2
  • 76
    • 77449146168 scopus 로고    scopus 로고
    • Interleukin-6 trans-signalling differentially regulates proliferation, migration, adhesion and maspin expression in human prostate cancer cells
    • Santer, F.R.; Malinowska, K.; Culig, Z.; Cavarretta, I.T. Interleukin-6 trans-signalling differentially regulates proliferation, migration, adhesion and maspin expression in human prostate cancer cells. Endocr. Relat. Cancer 2010, 17, 241-253.
    • (2010) Endocr. Relat. Cancer , vol.17 , pp. 241-253
    • Santer, F.R.1    Malinowska, K.2    Culig, Z.3    Cavarretta, I.T.4
  • 78
    • 37349098725 scopus 로고    scopus 로고
    • Autocrine IL-6 signaling: A key event in tumorigenesis?
    • Grivennikov, S.; Karin, M. Autocrine IL-6 signaling: A key event in tumorigenesis? Cancer Cell. 2008, 13, 7-9.
    • (2008) Cancer Cell. , vol.13 , pp. 7-9
    • Grivennikov, S.1    Karin, M.2
  • 79
    • 77957365010 scopus 로고    scopus 로고
    • Differential interleukin-6/STAT3 signaling as a function of cellular context mediates ras-induced transformation
    • Leslie, K.; Gao, S.P.; Berishaj, M.; Podsypanina, K.; Ho, H.; Ivashkiv, L.; Bromberg, J. Differential interleukin-6/STAT3 signaling as a function of cellular context mediates ras-induced transformation. Breast Cancer Res. 2010, 12, R80.
    • (2010) Breast Cancer Res. , vol.12
    • Leslie, K.1    Gao, S.P.2    Berishaj, M.3    Podsypanina, K.4    Ho, H.5    Ivashkiv, L.6    Bromberg, J.7
  • 81
    • 68149170225 scopus 로고    scopus 로고
    • Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells
    • Walter, M.; Liang, S.; Ghosh, S.; Hornsby, P.J.; Li, R. Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells. Oncogene 2009, 28, 2745-2755.
    • (2009) Oncogene , vol.28 , pp. 2745-2755
    • Walter, M.1    Liang, S.2    Ghosh, S.3    Hornsby, P.J.4    Li, R.5
  • 84
    • 34249868449 scopus 로고    scopus 로고
    • Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFκb
    • Yang, J.; Liao, X.; Agarwal, M.K.; Barnes, L.; Auron, P.E.; Stark, G.R. Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFκb. Genes Dev. 2007, 21, 1396-1408.
    • (2007) Genes Dev. , vol.21 , pp. 1396-1408
    • Yang, J.1    Liao, X.2    Agarwal, M.K.3    Barnes, L.4    Auron, P.E.5    Stark, G.R.6
  • 87
    • 78651474359 scopus 로고    scopus 로고
    • Local microbleeding facilitates IL-6- and IL-17-dependent arthritis in the absence of tissue antigen recognition by activated T cells
    • Murakami, M.; Okuyama, Y.; Ogura, H.; Asano, S.; Arima, Y.; Tsuruoka, M.; Harada, M.; Kanamoto, M.; Sawa, Y.; Iwakura, Y.; et al. Local microbleeding facilitates IL-6- and IL-17-dependent arthritis in the absence of tissue antigen recognition by activated T cells. J. Exp. Med. 2011, 208, 103-114.
    • (2011) J. Exp. Med. , vol.208 , pp. 103-114
    • Murakami, M.1    Okuyama, Y.2    Ogura, H.3    Asano, S.4    Arima, Y.5    Tsuruoka, M.6    Harada, M.7    Kanamoto, M.8    Sawa, Y.9    Iwakura, Y.10
  • 88
    • 0001903105 scopus 로고    scopus 로고
    • Dissection of signaling cascades through gp130 in vivo: Reciprocal roles for STAT3- and SHP2-mediated signals in immune responses
    • Ohtani, T.; Ishihara, K.; Atsumi, T.; Nishida, K.; Kaneko, Y.; Miyata, T.; Itoh, S.; Narimatsu, M.; Maeda, H.; Fukada, T.; et al. Dissection of signaling cascades through gp130 in vivo: Reciprocal roles for STAT3- and SHP2-mediated signals in immune responses. Immunity 2000, 12, 95-105.
    • (2000) Immunity , vol.12 , pp. 95-105
    • Ohtani, T.1    Ishihara, K.2    Atsumi, T.3    Nishida, K.4    Kaneko, Y.5    Miyata, T.6    Itoh, S.7    Narimatsu, M.8    Maeda, H.9    Fukada, T.10
  • 90
    • 12144289493 scopus 로고    scopus 로고
    • The point mutation of tyrosine 759 of the IL-6 family cytokine receptor gp130 synergizes with HTLV-1 PX in promoting rheumatoid arthritis-like arthritis
    • Ishihara, K.; Sawa, S.; Ikushima, H.; Hirota, S.; Atsumi, T.; Kamimura, D.; Park, S.J.; Murakami, M.; Kitamura, Y.; Iwakura, Y.; et al. The point mutation of tyrosine 759 of the IL-6 family cytokine receptor gp130 synergizes with HTLV-1 PX in promoting rheumatoid arthritis-like arthritis. Int. Immunol. 2004, 16, 455-465.
    • (2004) Int. Immunol. , vol.16 , pp. 455-465
    • Ishihara, K.1    Sawa, S.2    Ikushima, H.3    Hirota, S.4    Atsumi, T.5    Kamimura, D.6    Park, S.J.7    Murakami, M.8    Kitamura, Y.9    Iwakura, Y.10
  • 91
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • Harrington, L.E.; Hatton, R.D.; Mangan, P.R.; Turner, H.; Murphy, T.L.; Murphy, K.M.; Weaver, C.T. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat. Immunol. 2005, 6, 1123-1132.
    • (2005) Nat. Immunol. , vol.6 , pp. 1123-1132
    • Harrington, L.E.1    Hatton, R.D.2    Mangan, P.R.3    Turner, H.4    Murphy, T.L.5    Murphy, K.M.6    Weaver, C.T.7
  • 94
    • 33847667225 scopus 로고    scopus 로고
    • The role of T helper 17 (TH17) and regulatory T cells (TREG) in human organ transplantation and autoimmune disease
    • Afzali, B.; Lombardi, G.; Lechler, R.I.; Lord, G.M. The role of T helper 17 (TH17) and regulatory T cells (TREG) in human organ transplantation and autoimmune disease. Clin. Exp. Immunol. 2007, 148, 32-46.
    • (2007) Clin. Exp. Immunol. , vol.148 , pp. 32-46
    • Afzali, B.1    Lombardi, G.2    Lechler, R.I.3    Lord, G.M.4
  • 96
    • 33750465224 scopus 로고    scopus 로고
    • Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages
    • Kawane, K.; Ohtani, M.; Miwa, K.; Kizawa, T.; Kanbara, Y.; Yoshioka, Y.; Yoshikawa, H.; Nagata, S. Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages. Nature 2006, 443, 998-1002.
    • (2006) Nature , vol.443 , pp. 998-1002
    • Kawane, K.1    Ohtani, M.2    Miwa, K.3    Kizawa, T.4    Kanbara, Y.5    Yoshioka, Y.6    Yoshikawa, H.7    Nagata, S.8
  • 97
    • 78650606709 scopus 로고    scopus 로고
    • Cytokine-dependent but acquired immunity-independent arthritis caused by DNA escaped from degradation
    • Kawane, K.; Tanaka, H.; Kitahara, Y.; Shimaoka, S.; Nagata, S. Cytokine-dependent but acquired immunity-independent arthritis caused by DNA escaped from degradation. Proc. Natl. Acad. Sci. USA 2010, 107, 19432-19437.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 19432-19437
    • Kawane, K.1    Tanaka, H.2    Kitahara, Y.3    Shimaoka, S.4    Nagata, S.5
  • 98
    • 0026039673 scopus 로고
    • Transgenic mice expressing human tumour necrosis factor: A predictive genetic model of arthritis
    • Keffer, J.; Probert, L.; Cazlaris, H.; Georgopoulos, S.; Kaslaris, E.; Kioussis, D.; Kollias, G. Transgenic mice expressing human tumour necrosis factor: A predictive genetic model of arthritis. Embo J. 1991, 10, 4025-4031.
    • (1991) Embo J. , vol.10 , pp. 4025-4031
    • Keffer, J.1    Probert, L.2    Cazlaris, H.3    Georgopoulos, S.4    Kaslaris, E.5    Kioussis, D.6    Kollias, G.7
  • 99
    • 0031005027 scopus 로고    scopus 로고
    • Synergy between interferon-ɣ and tumor necrosis factor-α in transcriptional activation is mediated by cooperation between signal transducer and activator of transcription 1 and nuclear factor κB
    • Ohmori, Y.; Schreiber, R.D.; Hamilton, T.A. Synergy between interferon-ɣ and tumor necrosis factor-α in transcriptional activation is mediated by cooperation between signal transducer and activator of transcription 1 and nuclear factor κB. J. Biol. Chem. 1997, 272, 14899-14907.
    • (1997) J. Biol. Chem. , vol.272 , pp. 14899-14907
    • Ohmori, Y.1    Schreiber, R.D.2    Hamilton, T.A.3
  • 100
    • 84919940967 scopus 로고    scopus 로고
    • Prolonged tumor necrosis factor α primes fibroblast-like synoviocytes in a gene-specific manner by altering chromatin
    • Sohn, C.; Lee, A.; Qiao, Y.; Loupasakis, K.; Ivashkiv, L.B.; Kalliolias, G.D. Prolonged tumor necrosis factor α primes fibroblast-like synoviocytes in a gene-specific manner by altering chromatin. Arthritis Rheumatol. 2015, 67, 86-95.
    • (2015) Arthritis Rheumatol. , vol.67 , pp. 86-95
    • Sohn, C.1    Lee, A.2    Qiao, Y.3    Loupasakis, K.4    Ivashkiv, L.B.5    Kalliolias, G.D.6
  • 101
    • 0345826123 scopus 로고    scopus 로고
    • Interleukin 1 activates STAT3/nuclear factor-κb cross-talk via a unique TRAF6- and p65-dependent mechanism
    • Yoshida, Y.; Kumar, A.; Koyama, Y.; Peng, H.; Arman, A.; Boch, J.A.; Auron, P.E. Interleukin 1 activates STAT3/nuclear factor-κb cross-talk via a unique TRAF6- and p65-dependent mechanism. J. Biol. Chem. 2004, 279, 1768-1776.
    • (2004) J. Biol. Chem. , vol.279 , pp. 1768-1776
    • Yoshida, Y.1    Kumar, A.2    Koyama, Y.3    Peng, H.4    Arman, A.5    Boch, J.A.6    Auron, P.E.7
  • 102
    • 0037394635 scopus 로고    scopus 로고
    • Overexpressed nuclear factor-κb can participate in endogenous C-reactive protein induction, and enhances the effects of C/EBPβ and signal transducer and activator of transcription-3
    • Agrawal, A.; Cha-Molstad, H.; Samols, D.; Kushner, I. Overexpressed nuclear factor-κb can participate in endogenous C-reactive protein induction, and enhances the effects of C/EBPβ and signal transducer and activator of transcription-3. Immunology 2003, 108, 539-547.
    • (2003) Immunology , vol.108 , pp. 539-547
    • Agrawal, A.1    Cha-Molstad, H.2    Samols, D.3    Kushner, I.4
  • 103
    • 80155168933 scopus 로고    scopus 로고
    • Influence of janus kinase inhibition on interleukin 6-mediated induction of acute-phase serum amyloid a in rheumatoid synovium
    • Migita, K.; Koga, T.; Komori, A.; Torigoshi, T.; Maeda, Y.; Izumi, Y.; Sato, J.; Jiuchi, Y.; Miyashita, T.; Yamasaki, S.; et al. Influence of janus kinase inhibition on interleukin 6-mediated induction of acute-phase serum amyloid a in rheumatoid synovium. J. Rheumatol. 2011, 38, 2309-2317.
    • (2011) J. Rheumatol. , vol.38 , pp. 2309-2317
    • Migita, K.1    Koga, T.2    Komori, A.3    Torigoshi, T.4    Maeda, Y.5    Izumi, Y.6    Sato, J.7    Jiuchi, Y.8    Miyashita, T.9    Yamasaki, S.10
  • 105
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • Akira, S.; Uematsu, S.; Takeuchi, O. Pathogen recognition and innate immunity. Cell 2006, 124, 783-801.
    • (2006) Cell , vol.124 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 106
    • 17244381179 scopus 로고    scopus 로고
    • Innate immunity and arthritis: Neutrophil Rac and toll-like receptor 4 expression define outcomes in infection-triggered arthritis
    • Zhang, X.; Glogauer, M.; Zhu, F.; Kim, T.H.; Chiu, B.; Inman, R.D. Innate immunity and arthritis: Neutrophil Rac and toll-like receptor 4 expression define outcomes in infection-triggered arthritis. Arthritis Rheum. 2005, 52, 1297-1304.
    • (2005) Arthritis Rheum. , vol.52 , pp. 1297-1304
    • Zhang, X.1    Glogauer, M.2    Zhu, F.3    Kim, T.H.4    Chiu, B.5    Inman, R.D.6
  • 107
    • 57349192121 scopus 로고    scopus 로고
    • Overexpression of toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: Toll-like receptor expression in early and longstanding arthritis
    • Ospelt, C.; Brentano, F.; Rengel, Y.; Stanczyk, J.; Kolling, C.; Tak, P.P.; Gay, R.E.; Gay, S.; Kyburz, D. Overexpression of toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: Toll-like receptor expression in early and longstanding arthritis. Arthritis Rheum. 2008, 58, 3684-3692.
    • (2008) Arthritis Rheum. , vol.58 , pp. 3684-3692
    • Ospelt, C.1    Brentano, F.2    Rengel, Y.3    Stanczyk, J.4    Kolling, C.5    Tak, P.P.6    Gay, R.E.7    Gay, S.8    Kyburz, D.9
  • 108
    • 77950343791 scopus 로고    scopus 로고
    • Pattern recognition receptors and inflammation
    • Takeuchi, O.; Akira, S. Pattern recognition receptors and inflammation. Cell 2010, 140, 805-820.
    • (2010) Cell , vol.140 , pp. 805-820
    • Takeuchi, O.1    Akira, S.2
  • 110
    • 33847680512 scopus 로고    scopus 로고
    • Toll-like receptor 2 and 4 combination engagement upregulate IL-15 synergistically in human rheumatoid synovial fibroblasts
    • Jung, Y.O.; Cho, M.L.; Kang, C.M.; Jhun, J.Y.; Park, J.S.; Oh, H.J.; Min, J.K.; Park, S.H.; Kim, H.Y. Toll-like receptor 2 and 4 combination engagement upregulate IL-15 synergistically in human rheumatoid synovial fibroblasts. Immunol. Lett. 2007, 109, 21-27.
    • (2007) Immunol. Lett. , vol.109 , pp. 21-27
    • Jung, Y.O.1    Cho, M.L.2    Kang, C.M.3    Jhun, J.Y.4    Park, J.S.5    Oh, H.J.6    Min, J.K.7    Park, S.H.8    Kim, H.Y.9
  • 113
    • 0037333990 scopus 로고    scopus 로고
    • Bacterial peptidoglycans but not CPG oligodeoxynucleotides activate synovial fibroblasts by toll-like receptor signaling
    • Kyburz, D.; Rethage, J.; Seibl, R.; Lauener, R.; Gay, R.E.; Carson, D.A.; Gay, S. Bacterial peptidoglycans but not CPG oligodeoxynucleotides activate synovial fibroblasts by toll-like receptor signaling. Arthritis Rheum. 2003, 48, 642-650.
    • (2003) Arthritis Rheum. , vol.48 , pp. 642-650
    • Kyburz, D.1    Rethage, J.2    Seibl, R.3    Lauener, R.4    Gay, R.E.5    Carson, D.A.6    Gay, S.7
  • 114
    • 84861012395 scopus 로고    scopus 로고
    • Triggering of the dsRNA sensors TLR3, MDA5, and RIG-I induces CD55 expression in synovial fibroblasts
    • Karpus, O.N.; Heutinck, K.M.; Wijnker, P.J.; Tak, P.P.; Hamann, J. Triggering of the dsRNA sensors TLR3, MDA5, and RIG-I induces CD55 expression in synovial fibroblasts. PLoS ONE 2012, 7, e35606.
    • (2012) PLoS ONE , vol.7
    • Karpus, O.N.1    Heutinck, K.M.2    Wijnker, P.J.3    Tak, P.P.4    Hamann, J.5
  • 116
    • 23644449245 scopus 로고    scopus 로고
    • The expression of toll-like receptors 3 and 7 in rheumatoid arthritis synovium is increased and costimulation of toll-like receptors 3, 4, and 7/8 results in synergistic cytokine production by dendritic cells
    • Roelofs, M.F.; Joosten, L.A.; Abdollahi-Roodsaz, S.; van Lieshout, A.W.; Sprong, T.; van den Hoogen, F.H.; van den Berg, W.B.; Radstake, T.R. The expression of toll-like receptors 3 and 7 in rheumatoid arthritis synovium is increased and costimulation of toll-like receptors 3, 4, and 7/8 results in synergistic cytokine production by dendritic cells. Arthritis Rheum. 2005, 52, 2313-2322.
    • (2005) Arthritis Rheum. , vol.52 , pp. 2313-2322
    • Roelofs, M.F.1    Joosten, L.A.2    Abdollahi-Roodsaz, S.3    van Lieshout, A.W.4    Sprong, T.5    van den Hoogen, F.H.6    van den Berg, W.B.7    Radstake, T.R.8
  • 117
    • 25444443335 scopus 로고    scopus 로고
    • RNA released from necrotic synovial fluid cells activates rheumatoid arthritis synovial fibroblasts via toll-like receptor 3
    • Brentano, F.; Schorr, O.; Gay, R.E.; Gay, S.; Kyburz, D. RNA released from necrotic synovial fluid cells activates rheumatoid arthritis synovial fibroblasts via toll-like receptor 3. Arthritis Rheum. 2005, 52, 2656-2665.
    • (2005) Arthritis Rheum. , vol.52 , pp. 2656-2665
    • Brentano, F.1    Schorr, O.2    Gay, R.E.3    Gay, S.4    Kyburz, D.5
  • 118
    • 36348968386 scopus 로고    scopus 로고
    • Pharmacologic inhibition of TPL2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood
    • Hall, J.P.; Kurdi, Y.; Hsu, S.; Cuozzo, J.; Liu, J.; Telliez, J.B.; Seidl, K.J.; Winkler, A.; Hu, Y.; Green, N.; et al. Pharmacologic inhibition of TPL2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood. J. Biol. Chem. 2007, 282, 33295-33304.
    • (2007) J. Biol. Chem. , vol.282 , pp. 33295-33304
    • Hall, J.P.1    Kurdi, Y.2    Hsu, S.3    Cuozzo, J.4    Liu, J.5    Telliez, J.B.6    Seidl, K.J.7    Winkler, A.8    Hu, Y.9    Green, N.10
  • 119
    • 34247881945 scopus 로고    scopus 로고
    • Human rheumatoid synovial fibroblasts promote osteoclastogenic activity by activating rankl via TLR-2 and TLR-4 activation
    • Kim, K.W.; Cho, M.L.; Lee, S.H.; Oh, H.J.; Kang, C.M.; Ju, J.H.; Min, S.Y.; Cho, Y.G.; Park, S.H.; Kim, H.Y. Human rheumatoid synovial fibroblasts promote osteoclastogenic activity by activating rankl via TLR-2 and TLR-4 activation. Immunol. Lett. 2007, 110, 54-64.
    • (2007) Immunol. Lett. , vol.110 , pp. 54-64
    • Kim, K.W.1    Cho, M.L.2    Lee, S.H.3    Oh, H.J.4    Kang, C.M.5    Ju, J.H.6    Min, S.Y.7    Cho, Y.G.8    Park, S.H.9    Kim, H.Y.10
  • 121
    • 59649115416 scopus 로고    scopus 로고
    • Expression, regulation, and signaling of the pattern-recognition receptor nucleotide-binding oligomerization domain 2 in rheumatoid arthritis synovial fibroblasts
    • Ospelt, C.; Brentano, F.; Jungel, A.; Rengel, Y.; Kolling, C.; Michel, B.A.; Gay, R.E.; Gay, S. Expression, regulation, and signaling of the pattern-recognition receptor nucleotide-binding oligomerization domain 2 in rheumatoid arthritis synovial fibroblasts. Arthritis Rheum. 2009, 60, 355-363.
    • (2009) Arthritis Rheum. , vol.60 , pp. 355-363
    • Ospelt, C.1    Brentano, F.2    Jungel, A.3    Rengel, Y.4    Kolling, C.5    Michel, B.A.6    Gay, R.E.7    Gay, S.8
  • 122
    • 84860439543 scopus 로고    scopus 로고
    • The pattern-recognition receptor nucleotide-binding oligomerization domain-Containing protein 1 promotes production of inflammatory mediators in rheumatoid arthritis synovial fibroblasts
    • Yokota, K.; Miyazaki, T.; Hemmatazad, H.; Gay, R.E.; Kolling, C.; Fearon, U.; Suzuki, H.; Mimura, T.; Gay, S.; Ospelt, C. The pattern-recognition receptor nucleotide-binding oligomerization domain-Containing protein 1 promotes production of inflammatory mediators in rheumatoid arthritis synovial fibroblasts. Arthritis Rheum. 2012, 64, 1329-1337.
    • (2012) Arthritis Rheum. , vol.64 , pp. 1329-1337
    • Yokota, K.1    Miyazaki, T.2    Hemmatazad, H.3    Gay, R.E.4    Kolling, C.5    Fearon, U.6    Suzuki, H.7    Mimura, T.8    Gay, S.9    Ospelt, C.10
  • 123
    • 35648992652 scopus 로고    scopus 로고
    • Key differences in TLR3/poly I:C signaling and cytokine induction by human primary cells: A phenomenon absent from murine cell systems
    • Lundberg, A.M.; Drexler, S.K.; Monaco, C.; Williams, L.M.; Sacre, S.M.; Feldmann, M.; Foxwell, B.M. Key differences in TLR3/poly I:C signaling and cytokine induction by human primary cells: A phenomenon absent from murine cell systems. Blood 2007, 110, 3245-3252.
    • (2007) Blood , vol.110 , pp. 3245-3252
    • Lundberg, A.M.1    Drexler, S.K.2    Monaco, C.3    Williams, L.M.4    Sacre, S.M.5    Feldmann, M.6    Foxwell, B.M.7
  • 125
    • 79958034076 scopus 로고    scopus 로고
    • RNA sensors in human osteoarthritis and rheumatoid arthritis synovial fibroblasts: Immune regulation by vasoactive intestinal peptide
    • Carrion, M.; Juarranz, Y.; Perez-Garcia, S.; Jimeno, R.; Pablos, J.L.; Gomariz, R.P.; Gutierrez-Canas, I. RNA sensors in human osteoarthritis and rheumatoid arthritis synovial fibroblasts: Immune regulation by vasoactive intestinal peptide. Arthritis Rheum. 2011, 63, 1626-1636.
    • (2011) Arthritis Rheum. , vol.63 , pp. 1626-1636
    • Carrion, M.1    Juarranz, Y.2    Perez-Garcia, S.3    Jimeno, R.4    Pablos, J.L.5    Gomariz, R.P.6    Gutierrez-Canas, I.7
  • 127
    • 17644366913 scopus 로고    scopus 로고
    • NOD-LRR proteins: Role in host-microbial interactions and inflammatory disease
    • Inohara, N.; Chamaillard, M.; McDonald, C.; Nunez, G. NOD-LRR proteins: Role in host-microbial interactions and inflammatory disease. Annu. Rev. Biochem. 2005, 74, 355-383.
    • (2005) Annu. Rev. Biochem. , vol.74 , pp. 355-383
    • Inohara, N.1    Chamaillard, M.2    McDonald, C.3    Nunez, G.4
  • 128
    • 27944510972 scopus 로고    scopus 로고
    • Expression of interferon β in synovial tissue from patients with rheumatoid arthritis: Comparison with patients with osteoarthritis and reactive arthritis
    • Van Holten, J.; Smeets, T.J.; Blankert, P.; Tak, P.P. Expression of interferon β in synovial tissue from patients with rheumatoid arthritis: Comparison with patients with osteoarthritis and reactive arthritis. Ann. Rheum. Dis. 2005, 64, 1780-1782.
    • (2005) Ann. Rheum. Dis. , vol.64 , pp. 1780-1782
    • Van Holten, J.1    Smeets, T.J.2    Blankert, P.3    Tak, P.P.4
  • 129
    • 33144463109 scopus 로고    scopus 로고
    • Chemokine and chemokine receptor expression in paired peripheral blood mononuclear cells and synovial tissue of patients with rheumatoid arthritis, osteoarthritis, and reactive arthritis
    • Haringman, J.J.; Smeets, T.J.; Reinders-Blankert, P.; Tak, P.P. Chemokine and chemokine receptor expression in paired peripheral blood mononuclear cells and synovial tissue of patients with rheumatoid arthritis, osteoarthritis, and reactive arthritis. Ann. Rheum. Dis. 2006, 65, 294-300.
    • (2006) Ann. Rheum. Dis. , vol.65 , pp. 294-300
    • Haringman, J.J.1    Smeets, T.J.2    Reinders-Blankert, P.3    Tak, P.P.4
  • 130
    • 10444242596 scopus 로고    scopus 로고
    • CC and CXC chemokine receptors mediate migration, proliferation, and matrix metalloproteinase production by fibroblast-like synoviocytes from rheumatoid arthritis patients
    • Garcia-Vicuna, R.; Gomez-Gaviro, M.V.; Dominguez-Luis, M.J.; Pec, M.K.; Gonzalez-Alvaro, I.; Alvaro-Gracia, J.M.; Diaz-Gonzalez, F. CC and CXC chemokine receptors mediate migration, proliferation, and matrix metalloproteinase production by fibroblast-like synoviocytes from rheumatoid arthritis patients. Arthritis Rheum. 2004, 50, 3866-3877.
    • (2004) Arthritis Rheum. , vol.50 , pp. 3866-3877
    • Garcia-Vicuna, R.1    Gomez-Gaviro, M.V.2    Dominguez-Luis, M.J.3    Pec, M.K.4    Gonzalez-Alvaro, I.5    Alvaro-Gracia, J.M.6    Diaz-Gonzalez, F.7
  • 132
    • 33947129740 scopus 로고    scopus 로고
    • Antiviral gene expression in rheumatoid arthritis: Role of ikkepsilon and interferon regulatory factor 3
    • Sweeney, S.E.; Mo, L.; Firestein, G.S. Antiviral gene expression in rheumatoid arthritis: Role of ikkepsilon and interferon regulatory factor 3. Arthritis Rheum. 2007, 56, 743-752.
    • (2007) Arthritis Rheum. , vol.56 , pp. 743-752
    • Sweeney, S.E.1    Mo, L.2    Firestein, G.S.3
  • 133
    • 4344658402 scopus 로고    scopus 로고
    • Induction and regulation of ifns during viral infections
    • Malmgaard, L. Induction and regulation of ifns during viral infections. J. Interferon Cytokine Res. 2004, 24, 439-454.
    • (2004) J. Interferon Cytokine Res. , vol.24 , pp. 439-454
    • Malmgaard, L.1
  • 134
    • 73249143991 scopus 로고    scopus 로고
    • A critical role of cyr61 in interleukin-17-dependent proliferation of fibroblast-like synoviocytes in rheumatoid arthritis
    • Zhang, Q.; Wu, J.; Cao, Q.; Xiao, L.; Wang, L.; He, D.; Ouyang, G.; Lin, J.; Shen, B.; Shi, Y.; et al. A critical role of cyr61 in interleukin-17-dependent proliferation of fibroblast-like synoviocytes in rheumatoid arthritis. Arthritis Rheum. 2009, 60, 3602-3612.
    • (2009) Arthritis Rheum. , vol.60 , pp. 3602-3612
    • Zhang, Q.1    Wu, J.2    Cao, Q.3    Xiao, L.4    Wang, L.5    He, D.6    Ouyang, G.7    Lin, J.8    Shen, B.9    Shi, Y.10
  • 135
    • 0034942860 scopus 로고    scopus 로고
    • NF-κB in rheumatoid arthritis: A pivotal regulator of inflammation, hyperplasia, and tissue destruction
    • Makarov, S.S. NF-κB in rheumatoid arthritis: A pivotal regulator of inflammation, hyperplasia, and tissue destruction. Arthritis Res. 2001, 3, 200-206.
    • (2001) Arthritis Res. , vol.3 , pp. 200-206
    • Makarov, S.S.1
  • 136
    • 20844433059 scopus 로고    scopus 로고
    • Gene transfer of tissue inhibitor of metalloproteinases-3 reverses the inhibitory effects of TNF-α on Fas-induced apoptosis in rheumatoid arthritis synovial fibroblasts
    • Drynda, A.; Quax, P.H.; Neumann, M.; van der Laan, W.H.; Pap, G.; Drynda, S.; Meinecke, I.; Kekow, J.; Neumann, W.; Huizinga, T.W.; et al. Gene transfer of tissue inhibitor of metalloproteinases-3 reverses the inhibitory effects of TNF-α on Fas-induced apoptosis in rheumatoid arthritis synovial fibroblasts. J. Immunol. 2005, 174, 6524-6531.
    • (2005) J. Immunol. , vol.174 , pp. 6524-6531
    • Drynda, A.1    Quax, P.H.2    Neumann, M.3    van der Laan, W.H.4    Pap, G.5    Drynda, S.6    Meinecke, I.7    Kekow, J.8    Neumann, W.9    Huizinga, T.W.10
  • 137
    • 18144416502 scopus 로고    scopus 로고
    • Tumor necrosis factor-related apoptosis-inducing ligand (trail) induces rheumatoid arthritis synovial fibroblast proliferation through mitogen-activated protein kinases and phosphatidylinositol 3-kinase/AKT
    • Morel, J.; Audo, R.; Hahne, M.; Combe, B. Tumor necrosis factor-related apoptosis-inducing ligand (trail) induces rheumatoid arthritis synovial fibroblast proliferation through mitogen-activated protein kinases and phosphatidylinositol 3-kinase/AKT. J. Biol. Chem. 2005, 280, 15709-15718.
    • (2005) J. Biol. Chem. , vol.280 , pp. 15709-15718
    • Morel, J.1    Audo, R.2    Hahne, M.3    Combe, B.4
  • 139
    • 33748762258 scopus 로고    scopus 로고
    • JAB1 determines the response of rheumatoid arthritis synovial fibroblasts to tumor necrosis factor-α
    • Wang, J.; Li, C.; Liu, Y.; Mei, W.; Yu, S.; Liu, C.; Zhang, L.; Cao, X.; Kimberly, R.P.; Grizzle, W.; et al. JAB1 determines the response of rheumatoid arthritis synovial fibroblasts to tumor necrosis factor-α. Am. J. Pathol. 2006, 169, 889-902.
    • (2006) Am. J. Pathol. , vol.169 , pp. 889-902
    • Wang, J.1    Li, C.2    Liu, Y.3    Mei, W.4    Yu, S.5    Liu, C.6    Zhang, L.7    Cao, X.8    Kimberly, R.P.9    Grizzle, W.10
  • 140
    • 0030885421 scopus 로고    scopus 로고
    • Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis C-IAP2 is under NF-κB control
    • Chu, Z.L.; McKinsey, T.A.; Liu, L.; Gentry, J.J.; Malim, M.H.; Ballard, D.W. Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis C-IAP2 is under NF-κB control. Proc. Natl. Acad. Sci. USA 1997, 94, 10057-10062.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 10057-10062
    • Chu, Z.L.1    McKinsey, T.A.2    Liu, L.3    Gentry, J.J.4    Malim, M.H.5    Ballard, D.W.6
  • 141
    • 33646468506 scopus 로고    scopus 로고
    • Fas activation of a proinflammatory program in rheumatoid synoviocytes and its regulation by flip and caspase 8 signaling
    • Palao, G.; Santiago, B.; Galindo, M.A.; Rullas, J.N.; Alcami, J.; Ramirez, J.C.; Pablos, J.L. Fas activation of a proinflammatory program in rheumatoid synoviocytes and its regulation by flip and caspase 8 signaling. Arthritis Rheum. 2006, 54, 1473-1481.
    • (2006) Arthritis Rheum. , vol.54 , pp. 1473-1481
    • Palao, G.1    Santiago, B.2    Galindo, M.A.3    Rullas, J.N.4    Alcami, J.5    Ramirez, J.C.6    Pablos, J.L.7
  • 142
    • 0034049908 scopus 로고    scopus 로고
    • Gene therapy that inhibits nuclear translocation of nuclear factor κB results in tumor necrosis factor α-induced apoptosis of human synovial fibroblasts
    • Zhang, H.G.; Huang, N.; Liu, D.; Bilbao, L.; Zhang, X.; Yang, P.; Zhou, T.; Curiel, D.T.; Mountz, J.D. Gene therapy that inhibits nuclear translocation of nuclear factor κB results in tumor necrosis factor α-induced apoptosis of human synovial fibroblasts. Arthritis Rheum. 2000, 43, 1094-1105.
    • (2000) Arthritis Rheum. , vol.43 , pp. 1094-1105
    • Zhang, H.G.1    Huang, N.2    Liu, D.3    Bilbao, L.4    Zhang, X.5    Yang, P.6    Zhou, T.7    Curiel, D.T.8    Mountz, J.D.9
  • 143
    • 0029858348 scopus 로고    scopus 로고
    • RIP mediates tumor necrosis factor receptor 1 activation of NF-κB but not Fas/APO-1-initiated apoptosis
    • Ting, A.T.; Pimentel-Muinos, F.X.; Seed, B. RIP mediates tumor necrosis factor receptor 1 activation of NF-κB but not Fas/APO-1-initiated apoptosis. Embo J. 1996, 15, 6189-6196.
    • (1996) Embo J. , vol.15 , pp. 6189-6196
    • Ting, A.T.1    Pimentel-Muinos, F.X.2    Seed, B.3
  • 144
    • 0030999057 scopus 로고    scopus 로고
    • NF-κB rela-deficient lymphocytes: Normal development of T cells and B cells, impaired production of IGA and IGG1 and reduced proliferative responses
    • Doi, T.S.; Takahashi, T.; Taguchi, O.; Azuma, T.; Obata, Y. NF-κB rela-deficient lymphocytes: Normal development of T cells and B cells, impaired production of IGA and IGG1 and reduced proliferative responses. J. Exp. Med. 1997, 185, 953-961.
    • (1997) J. Exp. Med. , vol.185 , pp. 953-961
    • Doi, T.S.1    Takahashi, T.2    Taguchi, O.3    Azuma, T.4    Obata, Y.5
  • 145
    • 0031932422 scopus 로고    scopus 로고
    • Inhibition of proinflammatory molecule production by adenovirus-mediated expression of a nuclear factor κB super-repressor in human intestinal epithelial cells
    • Jobin, C.; Panja, A.; Hellerbrand, C.; Iimuro, Y.; Didonato, J.; Brenner, D.A.; Sartor, R.B. Inhibition of proinflammatory molecule production by adenovirus-mediated expression of a nuclear factor κB super-repressor in human intestinal epithelial cells. J. Immunol. 1998, 160, 410-418.
    • (1998) J. Immunol. , vol.160 , pp. 410-418
    • Jobin, C.1    Panja, A.2    Hellerbrand, C.3    Iimuro, Y.4    Didonato, J.5    Brenner, D.A.6    Sartor, R.B.7
  • 146
    • 62449202978 scopus 로고    scopus 로고
    • Cell death in rheumatoid arthritis
    • Korb, A.; Pavenstadt, H.; Pap, T. Cell death in rheumatoid arthritis. Apoptosis 2009, 14, 447-454.
    • (2009) Apoptosis , vol.14 , pp. 447-454
    • Korb, A.1    Pavenstadt, H.2    Pap, T.3
  • 148
    • 66049161848 scopus 로고    scopus 로고
    • Down-regulation of myeloid cell leukemia 1 by epigallocatechin-3-gallate sensitizes rheumatoid arthritis synovial fibroblasts to tumor necrosis factor α-induced apoptosis
    • Ahmed, S.; Silverman, M.D.; Marotte, H.; Kwan, K.; Matuszczak, N.; Koch, A.E. Down-regulation of myeloid cell leukemia 1 by epigallocatechin-3-gallate sensitizes rheumatoid arthritis synovial fibroblasts to tumor necrosis factor α-induced apoptosis. Arthritis Rheum. 2009, 60, 1282-1293.
    • (2009) Arthritis Rheum. , vol.60 , pp. 1282-1293
    • Ahmed, S.1    Silverman, M.D.2    Marotte, H.3    Kwan, K.4    Matuszczak, N.5    Koch, A.E.6
  • 149
    • 0036884944 scopus 로고    scopus 로고
    • Rheumatoid arthritis synoviocyte survival is dependent on STAT3
    • Krause, A.; Scaletta, N.; Ji, J.D.; Ivashkiv, L.B. Rheumatoid arthritis synoviocyte survival is dependent on STAT3. J. Immunol. 2002, 169, 6610-6616.
    • (2002) J. Immunol. , vol.169 , pp. 6610-6616
    • Krause, A.1    Scaletta, N.2    Ji, J.D.3    Ivashkiv, L.B.4
  • 150
    • 0036625960 scopus 로고    scopus 로고
    • The role of STATs in apoptosis
    • Battle, T.E.; Frank, D.A. The role of STATs in apoptosis. Curr. Mol. Med. 2002, 2, 381-392.
    • (2002) Curr. Mol. Med. , vol.2 , pp. 381-392
    • Battle, T.E.1    Frank, D.A.2
  • 151
    • 0035852765 scopus 로고    scopus 로고
    • Constitutively activated STAT3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated STAT1
    • Shen, Y.; Devgan, G.; Darnell, J.E., Jr.; Bromberg, J.F. Constitutively activated STAT3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated STAT1. Proc. Natl. Acad. Sci. USA 2001, 98, 1543-1548.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 1543-1548
    • Shen, Y.1    Devgan, G.2    Darnell, J.E.3    Bromberg, J.F.4
  • 153
    • 84873963986 scopus 로고    scopus 로고
    • IL-17-mediated BCL-2 expression regulates survival of fibroblast-like synoviocytes in rheumatoid arthritis through STAT3 activation
    • Lee, S.Y.; Kwok, S.K.; Son, H.J.; Ryu, J.G.; Kim, E.K.; Oh, H.J.; Cho, M.L.; Ju, J.H.; Park, S.H.; Kim, H.Y. IL-17-mediated BCL-2 expression regulates survival of fibroblast-like synoviocytes in rheumatoid arthritis through STAT3 activation. Arthritis Res. Ther. 2013, doi:10.1186/ar4179.
    • (2013) Arthritis Res. Ther.
    • Lee, S.Y.1    Kwok, S.K.2    Son, H.J.3    Ryu, J.G.4    Kim, E.K.5    Oh, H.J.6    Cho, M.L.7    Ju, J.H.8    Park, S.H.9    Kim, H.Y.10
  • 155
    • 33745298519 scopus 로고    scopus 로고
    • Nuclear factor-κB in cancer development and progression
    • Karin, M. Nuclear factor-κB in cancer development and progression. Nature 2006, 441, 431-436.
    • (2006) Nature , vol.441 , pp. 431-436
    • Karin, M.1
  • 159
    • 80054789761 scopus 로고    scopus 로고
    • Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity
    • Chien, Y.; Scuoppo, C.; Wang, X.; Fang, X.; Balgley, B.; Bolden, J.E.; Premsrirut, P.; Luo, W.; Chicas, A.; Lee, C.S.; et al. Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity. Genes Dev. 2011, 25, 2125-2136.
    • (2011) Genes Dev. , vol.25 , pp. 2125-2136
    • Chien, Y.1    Scuoppo, C.2    Wang, X.3    Fang, X.4    Balgley, B.5    Bolden, J.E.6    Premsrirut, P.7    Luo, W.8    Chicas, A.9    Lee, C.S.10
  • 160
    • 79955017452 scopus 로고    scopus 로고
    • P38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype
    • Freund, A.; Patil, C.K.; Campisi, J. P38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype. Embo J. 2011, 30, 1536-1548.
    • (2011) Embo J. , vol.30 , pp. 1536-1548
    • Freund, A.1    Patil, C.K.2    Campisi, J.3
  • 162
    • 33749549246 scopus 로고    scopus 로고
    • Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence
    • Coppe, J.P.; Kauser, K.; Campisi, J.; Beausejour, C.M. Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence. J. Biol. Chem. 2006, 281, 29568-29574.
    • (2006) J. Biol. Chem. , vol.281 , pp. 29568-29574
    • Coppe, J.P.1    Kauser, K.2    Campisi, J.3    Beausejour, C.M.4
  • 164
    • 84891713034 scopus 로고    scopus 로고
    • Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic ras and the p53 tumor suppressor
    • Coppe, J.P.; Patil, C.K.; Rodier, F.; Sun, Y.; Munoz, D.P.; Goldstein, J.; Nelson, P.S.; Desprez, P.Y.; Campisi, J. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic ras and the p53 tumor suppressor. PLoS Biol. 2008, 6, 2853-2868.
    • (2008) PLoS Biol. , vol.6 , pp. 2853-2868
    • Coppe, J.P.1    Patil, C.K.2    Rodier, F.3    Sun, Y.4    Munoz, D.P.5    Goldstein, J.6    Nelson, P.S.7    Desprez, P.Y.8    Campisi, J.9
  • 165
    • 61849093808 scopus 로고    scopus 로고
    • Chemical peels, dermabrasion, and laser therapy
    • Friedman, S.; Lippitz, J. Chemical peels, dermabrasion, and laser therapy. Dis. Mon. 2009, 55, 223-235.
    • (2009) Dis. Mon. , vol.55 , pp. 223-235
    • Friedman, S.1    Lippitz, J.2
  • 167
    • 13944260728 scopus 로고    scopus 로고
    • Stromal-epithelial interactions in aging and cancer: Senescent fibroblasts alter epithelial cell differentiation
    • Parrinello, S.; Coppe, J.P.; Krtolica, A.; Campisi, J. Stromal-epithelial interactions in aging and cancer: Senescent fibroblasts alter epithelial cell differentiation. J. Cell. Sci. 2005, 118, 485-496.
    • (2005) J. Cell. Sci. , vol.118 , pp. 485-496
    • Parrinello, S.1    Coppe, J.P.2    Krtolica, A.3    Campisi, J.4
  • 168
    • 84893044371 scopus 로고    scopus 로고
    • Senescence and the pro-tumorigenic stroma
    • Alspach, E.; Fu, Y.; Stewart, S.A. Senescence and the pro-tumorigenic stroma. Crit. Rev. Oncog. 2013, 18, 549-558.
    • (2013) Crit. Rev. Oncog. , vol.18 , pp. 549-558
    • Alspach, E.1    Fu, Y.2    Stewart, S.A.3
  • 170
    • 0037386222 scopus 로고    scopus 로고
    • Elevated angiogenin levels in synovial fluid from patients with inflammatory arthritis and secretion of angiogenin by cultured synovial fibroblasts
    • Liote, F.; Champy, R.; Moenner, M.; Boval-Boizard, B.; Badet, J. Elevated angiogenin levels in synovial fluid from patients with inflammatory arthritis and secretion of angiogenin by cultured synovial fibroblasts. Clin. Exp. Immunol. 2003, 132, 163-168.
    • (2003) Clin. Exp. Immunol. , vol.132 , pp. 163-168
    • Liote, F.1    Champy, R.2    Moenner, M.3    Boval-Boizard, B.4    Badet, J.5
  • 172
    • 67650662215 scopus 로고    scopus 로고
    • Inflammatory cells and chemokines sustain FGF2-induced angiogenesis
    • Presta, M.; Andres, G.; Leali, D.; Dell Era, P.; Ronca, R. Inflammatory cells and chemokines sustain FGF2-induced angiogenesis. Eur. Cytokine Netw. 2009, 20, 39-50.
    • (2009) Eur. Cytokine Netw. , vol.20 , pp. 39-50
    • Presta, M.1    Andres, G.2    Leali, D.3    Dell Era, P.4    Ronca, R.5
  • 173
    • 52049101546 scopus 로고    scopus 로고
    • Tumor microenvironment and angiogenesis
    • Nyberg, P.; Salo, T.; Kalluri, R. Tumor microenvironment and angiogenesis. Front. Biosci. 2008, 13, 6537-6553.
    • (2008) Front. Biosci. , vol.13 , pp. 6537-6553
    • Nyberg, P.1    Salo, T.2    Kalluri, R.3
  • 174
    • 0034721666 scopus 로고    scopus 로고
    • MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis
    • Coussens, L.M.; Tinkle, C.L.; Hanahan, D.; Werb, Z. MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis. Cell 2000, 103, 481-490.
    • (2000) Cell , vol.103 , pp. 481-490
    • Coussens, L.M.1    Tinkle, C.L.2    Hanahan, D.3    Werb, Z.4
  • 175
    • 4944239035 scopus 로고    scopus 로고
    • An amino-bisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis
    • Giraudo, E.; Inoue, M.; Hanahan, D. An amino-bisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis. J. Clin. Invest. 2004, 114, 623-633.
    • (2004) J. Clin. Invest. , vol.114 , pp. 623-633
    • Giraudo, E.1    Inoue, M.2    Hanahan, D.3
  • 177
    • 63049104211 scopus 로고    scopus 로고
    • Microenvironmental regulation of metastasis
    • Joyce, J.A.; Pollard, J.W. Microenvironmental regulation of metastasis. Nat. Rev. Cancer 2009, 9, 239-252.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 239-252
    • Joyce, J.A.1    Pollard, J.W.2
  • 178
    • 79953171126 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1α enhances haptoglobin gene expression by improving binding of STAT3 to the promoter
    • Oh, M.K.; Park, H.J.; Kim, N.H.; Park, S.J.; Park, I.Y.; Kim, I.S. Hypoxia-inducible factor-1α enhances haptoglobin gene expression by improving binding of STAT3 to the promoter. J. Biol. Chem. 2011, 286, 8857-8865.
    • (2011) J. Biol. Chem. , vol.286 , pp. 8857-8865
    • Oh, M.K.1    Park, H.J.2    Kim, N.H.3    Park, S.J.4    Park, I.Y.5    Kim, I.S.6
  • 181
    • 84934985384 scopus 로고    scopus 로고
    • Hypoxia and STAT3 signaling interactions regulate pro-inflammatory pathways in rheumatoid arthritis
    • Gao, W.; McCormick, J.; Connolly, M.; Balogh, E.; Veale, D.J.; Fearon, U. Hypoxia and STAT3 signaling interactions regulate pro-inflammatory pathways in rheumatoid arthritis. Ann. Rheum. Dis. 2014, 74, 1275-1283.
    • (2014) Ann. Rheum. Dis. , vol.74 , pp. 1275-1283
    • Gao, W.1    McCormick, J.2    Connolly, M.3    Balogh, E.4    Veale, D.J.5    Fearon, U.6
  • 182
    • 77149139874 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 as regulator of angiogenesis in rheumatoid arthritis-Therapeutic implications
    • Westra, J.; Molema, G.; Kallenberg, C.G. Hypoxia-inducible factor-1 as regulator of angiogenesis in rheumatoid arthritis-Therapeutic implications. Curr. Med. Chem. 2010, 17, 254-263.
    • (2010) Curr. Med. Chem. , vol.17 , pp. 254-263
    • Westra, J.1    Molema, G.2    Kallenberg, C.G.3
  • 183
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • Kalluri, R.; Weinberg, R.A. The basics of epithelial-mesenchymal transition. J. Clin. Invest. 2009, 119, 1420-1428.
    • (2009) J. Clin. Invest. , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 184
    • 63049123066 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits
    • Polyak, K.; Weinberg, R.A. Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits. Nat. Rev. Cancer 2009, 9, 265-273.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 265-273
    • Polyak, K.1    Weinberg, R.A.2
  • 185
    • 44449144396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition: AT the crossroads of development and tumor metastasis
    • Yang, J.; Weinberg, R.A. Epithelial-mesenchymal transition: AT the crossroads of development and tumor metastasis. Dev. Cell. 2008, 14, 818-829.
    • (2008) Dev. Cell. , vol.14 , pp. 818-829
    • Yang, J.1    Weinberg, R.A.2
  • 186
    • 80053249325 scopus 로고    scopus 로고
    • Twist1 is up-regulated in gastric cancer-associated fibroblasts with poor clinical outcomes
    • Sung, C.O.; Lee, K.W.; Han, S.; Kim, S.H. Twist1 is up-regulated in gastric cancer-associated fibroblasts with poor clinical outcomes. Am. J. Pathol. 2011, 179, 1827-1838.
    • (2011) Am. J. Pathol. , vol.179 , pp. 1827-1838
    • Sung, C.O.1    Lee, K.W.2    Han, S.3    Kim, S.H.4
  • 188
  • 189
    • 84903281074 scopus 로고    scopus 로고
    • Clinicopathological correlations of podoplanin (gp38) expression in rheumatoid synovium and its potential contribution to fibroblast platelet crosstalk
    • Del Rey, M.J.; Fare, R.; Izquierdo, E.; Usategui, A.; Rodriguez-Fernandez, J.L.; Suarez-Fueyo, A.; Canete, J.D.; Pablos, J.L. Clinicopathological correlations of podoplanin (gp38) expression in rheumatoid synovium and its potential contribution to fibroblast platelet crosstalk. PLoS ONE 2014, 9, e99607.
    • (2014) PLoS ONE , vol.9
    • Del Rey, M.J.1    Fare, R.2    Izquierdo, E.3    Usategui, A.4    Rodriguez-Fernandez, J.L.5    Suarez-Fueyo, A.6    Canete, J.D.7    Pablos, J.L.8
  • 192
    • 84870405287 scopus 로고    scopus 로고
    • Pi3 kinase/AKT/HIF-1α pathway is associated with hypoxia-induced epithelial-mesenchymal transition in fibroblast-like synoviocytes of rheumatoid arthritis
    • Li, G.Q.; Zhang, Y.; Liu, D.; Qian, Y.Y.; Zhang, H.; Guo, S.Y.; Sunagawa, M.; Hisamitsu, T.; Liu, Y.Q. Pi3 kinase/AKT/HIF-1α pathway is associated with hypoxia-induced epithelial-mesenchymal transition in fibroblast-like synoviocytes of rheumatoid arthritis. Mol. Cell. Biochem 2013, 372, 221-231.
    • (2013) Mol. Cell. Biochem , vol.372 , pp. 221-231
    • Li, G.Q.1    Zhang, Y.2    Liu, D.3    Qian, Y.Y.4    Zhang, H.5    Guo, S.Y.6    Sunagawa, M.7    Hisamitsu, T.8    Liu, Y.Q.9
  • 195
    • 77955605521 scopus 로고    scopus 로고
    • Cancer-associated fibroblasts and epithelial-mesenchymal transition in metastatic oral tongue squamous cell carcinoma
    • Vered, M.; Dayan, D.; Yahalom, R.; Dobriyan, A.; Barshack, I.; Bello, I.O.; Kantola, S.; Salo, T. Cancer-associated fibroblasts and epithelial-mesenchymal transition in metastatic oral tongue squamous cell carcinoma. Int. J. Cancer 2010, 127, 1356-1362.
    • (2010) Int. J. Cancer , vol.127 , pp. 1356-1362
    • Vered, M.1    Dayan, D.2    Yahalom, R.3    Dobriyan, A.4    Barshack, I.5    Bello, I.O.6    Kantola, S.7    Salo, T.8
  • 199
    • 66749098416 scopus 로고    scopus 로고
    • Collective invasion of carcinoma cells: When the fibroblasts take the lead
    • Gaggioli, C. Collective invasion of carcinoma cells: When the fibroblasts take the lead. Cell. Adh. Migr. 2008, 2, 45-47.
    • (2008) Cell. Adh. Migr. , vol.2 , pp. 45-47
    • Gaggioli, C.1
  • 202
    • 0033768507 scopus 로고    scopus 로고
    • Expression of osteoclast differentiation factor in rheumatoid arthritis
    • Shigeyama, Y.; Pap, T.; Kunzler, P.; Simmen, B.R.; Gay, R.E.; Gay, S. Expression of osteoclast differentiation factor in rheumatoid arthritis. Arthritis Rheum. 2000, 43, 2523-2530.
    • (2000) Arthritis Rheum. , vol.43 , pp. 2523-2530
    • Shigeyama, Y.1    Pap, T.2    Kunzler, P.3    Simmen, B.R.4    Gay, R.E.5    Gay, S.6
  • 203
    • 0035080457 scopus 로고    scopus 로고
    • Invasiveness of synovial fibroblasts is regulated by p53 in the SCID mouse in vivo model of cartilage invasion
    • Pap, T.; Aupperle, K.R.; Gay, S.; Firestein, G.S.; Gay, R.E. Invasiveness of synovial fibroblasts is regulated by p53 in the SCID mouse in vivo model of cartilage invasion. Arthritis Rheum. 2001, 44, 676-681.
    • (2001) Arthritis Rheum. , vol.44 , pp. 676-681
    • Pap, T.1    Aupperle, K.R.2    Gay, S.3    Firestein, G.S.4    Gay, R.E.5
  • 204
    • 0035066383 scopus 로고    scopus 로고
    • Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation
    • Kyriakis, J.M.; Avruch, J. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol. Rev. 2001, 81, 807-869.
    • (2001) Physiol. Rev. , vol.81 , pp. 807-869
    • Kyriakis, J.M.1    Avruch, J.2
  • 205
    • 0037811204 scopus 로고    scopus 로고
    • Induction of matrix metalloproteinase-13 gene expression by TNF-α is mediated by map kinases, AP-1, and NF-κB transcription factors in articular chondrocytes
    • Liacini, A.; Sylvester, J.; Li, W.Q.; Huang, W.; Dehnade, F.; Ahmad, M.; Zafarullah, M. Induction of matrix metalloproteinase-13 gene expression by TNF-α is mediated by map kinases, AP-1, and NF-κB transcription factors in articular chondrocytes. Exp. Cell. Res. 2003, 288, 208-217.
    • (2003) Exp. Cell. Res. , vol.288 , pp. 208-217
    • Liacini, A.1    Sylvester, J.2    Li, W.Q.3    Huang, W.4    Dehnade, F.5    Ahmad, M.6    Zafarullah, M.7
  • 206
    • 82455198750 scopus 로고    scopus 로고
    • Modulation of matrix metalloproteinase production by rheumatoid arthritis synovial fibroblasts after cadherin 11 engagement
    • Noss, E.H.; Chang, S.K.; Watts, G.F.; Brenner, M.B. Modulation of matrix metalloproteinase production by rheumatoid arthritis synovial fibroblasts after cadherin 11 engagement. Arthritis Rheum. 2011, 63, 3768-3778.
    • (2011) Arthritis Rheum. , vol.63 , pp. 3768-3778
    • Noss, E.H.1    Chang, S.K.2    Watts, G.F.3    Brenner, M.B.4
  • 207
    • 0035008915 scopus 로고    scopus 로고
    • Inhibition of transcription factor NF-κB reduces matrix metalloproteinase-1, -3 and -9 production by vascular smooth muscle cells
    • Bond, M.; Chase, A.J.; Baker, A.H.; Newby, A.C. Inhibition of transcription factor NF-κB reduces matrix metalloproteinase-1, -3 and -9 production by vascular smooth muscle cells. Cardiovasc. Res. 2001, 50, 556-565.
    • (2001) Cardiovasc. Res. , vol.50 , pp. 556-565
    • Bond, M.1    Chase, A.J.2    Baker, A.H.3    Newby, A.C.4
  • 208
    • 84865657365 scopus 로고    scopus 로고
    • Interleukin-17a promotes rheumatoid arthritis synoviocytes migration and invasion under hypoxia by increasing MMP2 and MMP9 expression through NF-κB/HIF-1α pathway
    • Li, G.; Zhang, Y.; Qian, Y.; Zhang, H.; Guo, S.; Sunagawa, M.; Hisamitsu, T.; Liu, Y. Interleukin-17a promotes rheumatoid arthritis synoviocytes migration and invasion under hypoxia by increasing MMP2 and MMP9 expression through NF-κB/HIF-1α pathway. Mol. Immunol. 2013, 53, 227-236.
    • (2013) Mol. Immunol. , vol.53 , pp. 227-236
    • Li, G.1    Zhang, Y.2    Qian, Y.3    Zhang, H.4    Guo, S.5    Sunagawa, M.6    Hisamitsu, T.7    Liu, Y.8
  • 209
    • 80055117937 scopus 로고    scopus 로고
    • IL-1α and TNFα-initiated IL-6-STAT3 pathway is critical in mediating inflammatory cytokines and rankl expression in inflammatory arthritis
    • Mori, T.; Miyamoto, T.; Yoshida, H.; Asakawa, M.; Kawasumi, M.; Kobayashi, T.; Morioka, H.; Chiba, K.; Toyama, Y.; Yoshimura, A. IL-1α and TNFα-initiated IL-6-STAT3 pathway is critical in mediating inflammatory cytokines and rankl expression in inflammatory arthritis. Int. Immunol. 2011, 23, 701-712.
    • (2011) Int. Immunol. , vol.23 , pp. 701-712
    • Mori, T.1    Miyamoto, T.2    Yoshida, H.3    Asakawa, M.4    Kawasumi, M.5    Kobayashi, T.6    Morioka, H.7    Chiba, K.8    Toyama, Y.9    Yoshimura, A.10


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