Inhibition of proinflammatory molecule production by adenovirus-mediated expression of a nuclear factor κB super-repressor in human intestinal epithelial cells

Journal of Immunology

Volumn 160, Issue 1, 1998, Pages 410-418

  Jobin, Christian ^a   Panja, Asit ^c   Hellerbrand, Claus ^b   Iimuro, Yuji ^b   Didonato, Joseph ^d   Brenner, David A ^b   Sartor, R Balfour ^a,b,e  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c MOUNT SINAI MEDICAL CENTER   (United States)

^d San Diego   (United States)

^e University of North Carolina at Chapel Hill   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITOR PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 8; NITRIC OXIDE SYNTHASE; NUCLEAR FACTOR KAPPA B SUPER REPRESSOR PROTEIN; PHORBOL 13 ACETATE 12 MYRISTATE; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VIRUS VECTOR;

ADENOVIRUS; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; ELECTROPHORETIC MOBILITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; INTESTINE EPITHELIUM CELL; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADENOVIRUSES, HUMAN; CELLS, CULTURED; COLON; EPITHELIAL CELLS; GENE EXPRESSION; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; IMMUNITY, MUCOSAL; INTERLEUKIN-1; INTERLEUKIN-8; NF-KAPPA B; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PROTO-ONCOGENE PROTEINS; RECOMBINANT PROTEINS; TETRADECANOYLPHORBOL ACETATE; TRANSCRIPTION FACTOR RELB; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0031932422     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Jung, H. C., L. Eckmann, S.-K. Yang, A. Panja, J. Fierer, E. Morzycka-Wroblewska, and M. F. Kagnoff. 1995. A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion. J. Clin. Invest. 95:55.
2. Sartor, R. B. 1995. Current concepts of the etiology and pathogenesis of ulcerative colitis and Crohn's disease. Gastroenterol. Clin. N. America 24:475.
3. Mayer, L., and R. Shlien. 1987. Evidence for function of Ia molecules on gut epithelial cells in man. J. Exp. MeJ 166:1471.
4. Kaiserlian, D., D. Rigal, J. Abello, and J.-P. Revillard. 1991. Expression, function and regulation of the intercellular molecule-1 (ICAM-1) on human intestinal epithelial cell lines. Eur. J. Immunol 21:2415.
5. Kvale, D., P. Krajci, and P. Brandtaeg. 1992. Expression and regulation of adhesion molecules ICAM-1 (CD54) and LFA-3 (CD58) in human intestinal cell lines. Scand. J. Immunol 35:669.
6. Eckmann, L., H. J. Jung, C. Schürer-Maly, A. Panja, E. Morzycka-Wroblewska, and M. J. Kagnoff. 1993. Differential cytokine expression by human intestinal epithelial cell lines: regulated expression of interleukin 8. Gastroenterology 105: 1689.
7. Eckmann, L., M. F. Kagnoff, and J. Fierer. 1993. Epithelial cells secrete the chemokine interleukin-8 in response to bacterial entry. Infect. Immunol. 61:4569.
8. Dias, V. C., J. L. Wallace, and H. G. Parsons. 1992. Modulation of cellular phospholipid fatty acids and leukotriene B4 in the human intestinal cell (Caco-2). Gut 33:622.
9. Kolios, G., Z. Brown, R. L. Robson, D. A. F. Robertson, and J. Westwick. 1995. Inducible nitric oxide synthase activity and expression in a human colonic epithelial cell line, HT-29. Br. J. Pharmacol. 116:2866.
10. Baeuerle, P. A., and T. Henkle. 1994. Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12:141.
11. Barnes, P. J., and M. Karin. 1997. Nuclear factor-κB, a pivotal transcription factor in chronic inflammatory diseases. N. Engl. J. Med 336:1066.
12. Baeuerle, P. A. 1991. The inducible transcription activator NF-κB: regulation by distinct protein subunits. Biochim. Biophys. Acta 1072:63.
13. Ruben, S. M., M. L. Narayanan, J. F. Klement, C.-H. Chen, and C. A. Rosen. 1992. Functional characterization of the NF-κB p65 transcriptional activator and an alternatively spliced derivative. Mol. Cell. Biol. 12:444.
14. Ballard, D. W., E. P. Dixon, N. J. Peffer, H. Bogerd, S. Doerre, B. Stein, and W. C. Greene. 1992. The 65-kDa subunit of human NF-κB functions as a potent transcriptional activator and a target for v-Rel-mediated repression. Proc. Natl. Acad. Sci. USA 89:1875 .
15. Jobin, C., S. Haskill, L. Mayer, A. Panja, and R. B. Sartor. 1997. Evidence for an altered regulation of IκBα degradation in human colonic epithelial cells. J. Immunol. 158:226.
16. Thanos, D., and T. Maniatis. 1995. NF-κB: a lesson in family values. Cell 80: 529.
17. Finco, T. S., and A. S. Baldwin. 1995. Mechanistic aspects of NF-κB regulation: the emerging role of phosphorylation and proteolysis. Immunity 3:263.
18. Brown, K., S. Gersberger, L. Carlson, G. Franzoso, and U. Siebenlist. 1995. Control of IκB-α proteolysis by site-specific, signal-induced phosphorylation. Science 267:1485.
19. Chen, Z., J. Hagler, V. J. Palombella, F. Melandri, D. Scherer, D. Ballard, and T. Maniatis. 1995. Signal-induced site-specific phosphorylation targets IκBα to the ubiquitin-proteasome pathway. Genes Dev. 9:1586.
20. Chen, Z. J., L. Parent, and T. Maniatis. 1996. Site-specific phosphorylation of IκBα by novel ubiquitination-dependent protein kinase activity. Cell 84:853.
21. Scherer, D. C., J. A. Brockman, Z. Chen, T. Maniatis, and D. W. Ballard. 1995. Signal-induced degradation of IκBα requires site-specific ubiquitination. Proc. Natl. Acad. Sci. USA 92:11259.
22. Traenckner, E. B.-M., S. Wilk, and P. A. Baeuerle. 1994. A proteasome inhibitor prevents activation of NF-κB and stabilizes a newly phosphorylated form of IκB-α that is still bound to NF-κB. EMBO J 13:5433.
23. Brockman, J. A., D. C. Scherer, T. A. McKinsey, S. M. Hall, X. Qi, W. Y. Lee, and D. W. Ballard. 1995. Coupling of a signal response domain in IκBα to multiple pathway for NF-κB activation. Mol. Cell. Biol. 15:2809.
24. Ali, M., N. R. Lemoine, and C. J. A. Ring. 1994. The use of DNA viruses as vectors for gene therapy. Gene Ther. 1:367.
25. Trapnell, B. C., and M. Gorziglia. 1994. Gene therapy using adenoviral vectors. Curr. Opin. Biotechnol. 5:617.
26. Warner, J. F., D. Jolly, S. Mento, J. Galpin, R. Haubrich, and J. Merritt. Retroviral vectors for HIV immunotherapy. Ann. NY Acad. Sci. 772:105.
27. Wang, C.-Y., M. W. Mayo, and A. S. Baldwin Jr. 1996. TNF-and cancer therapy-induced apoptosis: potentiation by inhibition of NF-κB. Science 274:784.
28. Panja, A., A. Barone, and L. Mayer. 1994. Stimulation of lamina propria lymphocytes by intestinal epithelial cells. J Exp. Med. 179:943.
29. Graham, F. L., and L. Prevec. 1991. Method for construction of adenovirus vectors. In Methods in Molecular Biology. E. J. Murray, ed. Humana, Clifton, NJ, p. 109.
30. Didonato, J., F. Mercurio, C. Rosette, J. Wu-Li, H. Suyang, S. Ghosh, and M. Karin. 1996. Mapping of the inducible IκB phosphorylation sites that signal its ubiquitination and degradation. Mol. Cell. Biol. 16:1295.
31. Johin, C., and J. Gauthier. 1997. Differential effects of cell density on 5-lipoxygenase (5-LO), tive-lipoxygenase-activating protein (FLAP) and interleukin-1β (IL-1β) expression in human neutrophils. Inflammation 21:235.
32. Watson, J. M., A. K. Lofquist, C. A. Rinehart, J. C. Olsen, S. S. Makarov, D. G. Kaufman, and J. S. Haskill. 1995. The intracellular IL-1 receptor antagonist alters IL-1-inducible gene expression without blocking exogenous signaling by IL-1β. J. Immunol. 155:4467.
33. Westwick, J. K., C. Weitzel, A. Minden, M. Karin, and D. A. Brenner. 1994. Tumor necrosis factor a stimulates AP-1 activity through prolonged activation of the c-Jun kinase. J. Biol. Chem. 269:26396.
34. Jobin, C., H. H. Herfarth, and R. B. Sartor. 1996. Dexamethasone inhibits TNF-α gene expression through an IκB/NF-κB pathway in intestinal IEC-6 cells. Gastroenterology 110:A333.
35. Hellerbrand, C., C. Jobin, R. B. Sartor, and D. A. Brenner. 1996. NF-κB mediates cytokine induced expression of ICAM-1 in IEC-6 cells. Gastroenternlogy 110: A329.
36. Wrighton, C. J., R. Hofer-Warbinek, T. Moll, R. Eytner, F. H. Bach, and R. deMartin. 1996. Inhibition of endothelial cell activation by adenovirus-mediated expression of IκBα, an inhibitor of transcription factor NF-κB. J. Exp. Med. 183:1013.
37. Read, M. A., A. S. Neish, M. E. Gerritsen, and T. Collins. 1996. Postinduction transcriptional repression of E-selectin and vascular adhesion molecule-1. J. Immunol. 157:3472.
38. Read, M. A., A. S. Neish, F. W. Luscinskas, V. J. Palombella, T. Maniatis, and T. Collins. 1995. The proteasome pathway is required for cytokine-induced endothelial-leukocyte adhesion molecule expression. Immunity 2:493.
39. Chen, C. C. C. L. Rosenbloom, D. C. Anderson, and A. M. Manning. 1995. Selective inhibition of E-selectin, vascular cell adhesion molecule-1, and intercellular adhesion molecule-1 expression by inhibition of IκB-α phosphorylation. J. Immunol. 155:3538.
40. Beauparlant, P., H. Kwon, M. Clarke, R. Lin, N. Sonenberg, M. Wainberg, and J. Hiscott. 1996. Transdominant mutants of IκBα block Tat-tumor necrosis factor synergistic activation of human immunodeficiency virus type 1 gene expression and virus multiplication. J. Virol. 70:5777.
41. Neurath, M., S. Pettersson, K.-H. Meyer Zum Buschenfelde, and W. Strober. 1996. Local administration of antisense phosphothioate oligonucleotides to the p65 subunit of NF-κB abrogates established experimental colitis in mice. Nat. Med. 2:998.
42. Yang, S.-K., L. Eckmann, A. Panja, and M. F. Kagnoff. 1997. Differential and regulated expression of C-X-C, C-C, and C-chemokines by human colon epithelial cells. Gastroenterology. 113:1214.
43. Yei, S., N. Mittereder, S. Wert, J. A. Whitsett, R. W. Wilmott, and B. C. Trapnell. 1994. In vivo evaluation of the safety of adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator cDNA to the lung. Hum. Gene Ther. 5:731.
44. Huang, T.-J. G., L. Eckmann, T. C. Savidge, and M. F. Kagnoff. 1996. Infection of human intestinal epithelial cells with invasive bacteria up-regulates apical intercellular adhesion molecule-1 (ICAM-1) expression and neutrophil adhesion. J. Clin. Invest. 98:572.
45. McCormick, B. A., S. P. Colgan, C. Delp-Archer, S. I. Miller, and J. L. Madara. 1993. Salmonella typhimurium attachment to human intestinal epithelial monolayers: transcellular signalling to subepithelial neutrophils. J. Cell. Biol 123:895.
46. Griscavage, J. M., S. Wilk, and L. J. Ignarro. 1996. Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-κB. Proc. Natl. Acad. Sci. USA 93:3308.
47. Boughton-Smith, N. K. 1994. Pathological and therapeutic implications for nitric oxide in inflammatory bowel disease. J. Royal Soc. Med. 87:312.
48. Karin, M. 1995. The regulation of AP-1 activity by mitogen-activated protein kinases. J. Biol. Chem. 270:16483.
49. Wu, G. D., E. J. Lai, N. Huang, and X. Wen. 1997. Oct-1 and CCAAT/enhancer-binding protein (C/EBP) bind to overlapping elements within the interleukin-8 promoter. J. Biol. Chem. 272:2396.