Overexpressed nuclear factor-κB can participate in endogenous C-reactive protein induction, and enhances the effects of C/EBPβ and signal transducer and activator of transcription-3

Immunology

Volumn 108, Issue 4, 2003, Pages 539-547

  Agrawal, Alok ^a   Cha Molstad, Hyunjoo ^a   Samols, David ^a   Kushner, Irving ^b  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b METROHEALTH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; CCAAT ENHANCER BINDING PROTEIN BETA; DIMER; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MESSENGER RNA; PROTEIN P50; STAT3 PROTEIN;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE EXPRESSION; GENE FUNCTION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN GENOME; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN INDUCTION; PROTEIN PROTEIN INTERACTION;

C-REACTIVE PROTEIN; CCAAT-ENHANCER-BINDING PROTEIN-BETA; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-1; NF-KAPPA B; NF-KAPPA B P50 SUBUNIT; RNA, MESSENGER; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TRANSCRIPTION FACTOR RELA; TUMOR CELLS, CULTURED;

EID: 0037394635     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.2003.01608.x     Document Type: Article

References (50)

1. Tillett WS, Francis T Jr. Serological reactions in pneumonia with a non-protein somatic fraction of pneumococcus. J Exp Med 1930; 52:561-71.
2. Kushner I. The phenomenon of the acute phase response. Ann NY Acad Sci USA 1982; 389:39-48.
3. Gabay C, Kushner I, Acute-phase proteins and other systemic responses to inflammation. N Engl J Med 1999; 340:448-54.
4. Volanakis JE. Human C-reactive protein: expression, structure and function. Mol Immunol 2001; 38:189-97.
5. Kushner I, Kaplan MH. Studies of acute phase protein. I. an immunohistochemical method for the localization of Cx-reactive protein in rabbits, association with necrosis in local inflammatory lesions. J Exp Med 1961; 114:961-73.
6. Volanakis JE, Kaplan MH. Specificity of C-reactive protein for choline phosphate residues of pneumococcal C-polysaccharide. Proc Soc Exp Biol Med 1971; 136:612-4.
7. Agrawal A, Simpson MJ, Black S, Carey MP, Samols D. A C-reactive protein mutant that does not bind to phosphocholine and pneumococcal C-polysaccharide. J Immunol 2002; 169:3217-22.
8. Kaplan MH, Volanakis JE. Interaction of C-reactive protein complexes with the complement system. I. Consumption of human complement associated with the reaction of C-reactive protein with pneumococcal C-polysaccharide and with the choline phosphatides, lecithin and sphingomyelin. J Immunol 1974; 112:2135-47.
9. Jiang H, Lint TF, Gewurz H. Defined chemically cross-linked oligomers of human C-reactive protein: characterization and reactivity with the complement system. Immunology 1991; 74:725-31.
10. Agrawal A, Shrive AK, Greenhough TJ, Volanakis JE, Topology and structure of the C1q-binding site on C-reactive protein. J Immunol 2001; 166:3998-4004.
11. Kushner I, Feldmann G. Control of the acute phase response. Demonstration of C-reactive protein synthesis and secretion by hepatocytes during acute inflammation in the rabbit. J Exp Med 1978; 148:466-77.
12. Ganapathi MK, May LT, Schultz D, Brabenec A, Weinstein J, Sehgal PB, Kushner I. Role of interleukin-6 in regulating synthesis of C-reactive protein and serum amyloid A in human hepatoma cell lines. Biochem Biophys Res Comm 1988; 157:271-7.
13. Ganter U, Arcone R, Toniatti C, Morrone G, Ciliberto G. Dual control of C-reactive protein gene expression by interleukin-1 and interleukin-6. EMBO J 1989; 8:3773-9.
14. Steel DM, Whitehead AS. Heterogeneous modulation of acute-phase-reactant mRNA levels by interleukin-1β and interleukin-6 in the human hepatoma cell line PLC/PRF/5. Biochem J 1991; 277:477-82.
15. Zhang D, Jiang S, Rzewnicki D, Samols D, Kushner I. The effect of interleukin-1 on C-reactive protein expression in Hep3B cells is exerted at the transcriptional level. Biochem J 1995; 310:143-8.
16. Weinhold B, Bader A, Poli V, Rüther U. Interleukin-6 is necessary, but not sufficient, for induction of the human C-reactive protein gene in vivo. Biochem J 1997; 325:617-21.
17. Ganapathi MK, Rzewnicki D, Samols D, Jiang S, Kushner I. Effect of combinations of cytokines and hormones on synthesis of serum amyloid A and C-reactive protein in Hep3B cells. J Immunol 1991; 147:1261-5.
18. Dinarello CA. Interleukin-1. Cytokine Growth Factor Rev 1997; 8:253-165.
19. Baeuerle PA, Baltimore D. NF-κB, ten years after. Cell 1996; 87:13-20.
20. Zhang D, Sun M, Samols D, Kushner I. STAT3 participates in transcriptional activation of the C-reactive protein gene by interleukin-6. J Biol Chem 1996; 271:9503-9.
21. Agrawal A, Cha-Molstad H, Samols D, Kushner I. Transactivation of C-reactive protein by IL-6 requires synergistic interactions of CCAAT/enhancer binding protein β (C/EBPβ) and Re1 p50. J Immunol 2001; 166:2378-84.
22. Cha-Molstad H, Agrawal A, Zhang D, Samols D, Kushner I. The Rel family member p50 mediates cytokine-induced C-reactive protein expression by a novel mechanism. J Immunol 2000; 165:4592-7.
23. Li S, Goldman ND. Regulation of human C-reactive protein gene expression by two synergistic IL-6 responsive elements. Biochemistry 1996; 35:9060-8.
24. Majello B, Arcone R, Toniatti C, Ciliberto G. Constitutive and IL-6-induced nuclear factors that interact with the human C-reactive protein promoter. EMBO J 1990; 9:457-65.
25. Bromberg JF, Wrzeszczynska MH, Devgan G, Zhao Y, Pestell RG, Albanese C, Damell JE Jr. STAT3 as an oncogene. Cell 1999; 98:295-303.
26. Jiang S, Samols D, Rzewnicki D, Macintyre SS, Greber I, Sipe J, Kushner I. Kinetic modeling and mathematical analysis indicate that acute phase gene expression in Hep3B cells is regulated by both transcriptional and posttranscriptional mechanisms. J Clin Invest 1995; 95:1253-61.
27. Schreiber E, Matthias P, Müller MM, Schaffner W. Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. Nucl Acids Res 1989; 17:6419.
28. Sen R, Baltimore D. Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 1986; 46:705-16.
29. Levy D, Kessler DS, Pine R, Darnell JE Jr. Cytoplasmic activation of ISGF3, the positive regulator of interferon-α-stimulated transcription, reconstituted in vitro. Genes Dev 1989; 3:1362-71.
30. International Human Genome Sequencing Consortium. Initial sequencing and analysis of the human genome. Nature 2001; 409:860-921.
31. Ganapathi MK, Schultz D, Mackiewicz A, Samols D, Hu S, Brabenec A, Macintyre SS, Kushner I. Heterogeneous nature of the acute phase response: differential regulation of human serum amyloid A, C-reactive protein, and other acute phase proteins by cytokines in Hep3B cells. J Immunol 1988; 141:564-9.
32. Betts JC, Cheshire JK, Akira S, Kishimoto T, Woo P. The role of NF-κB and NF-IL-6 transactivating factors in the synergistic activation of human serum amyloid A gene expression by interleukin-1 and interleukin-6. J Biol Chem 1993; 268:25624-31.
33. Matsusaka T, Fujikawa K, Nishio Y, Mukaida N, Matsushima K, Kishimoto T, Akira S. Transcription factor NF-IL-6 and NF-κB synergistically activate transcription of the inflammatory cytokines, interleukin-6 and interleukin-8. Proc Natl Acad Sci USA 1993; 90:10193-7.
34. Zhang Y, Rom WN. Regulation of the interleukin-β (IL-1β) gene by mycobacterial components and lipopolysaccharide is mediated by two nuclear factor-IL-6 motifs. Mol Cell Biol 1993; 13:3831-7.
35. Catron KM, Brickwood JR, Shang C, Li Y, Shannon MF, Parks TP. Cooperative binding and synergistic activation by Re1A and C/EBPβ on the intercellular adhesion molecule-1 promoter. Cell Growth Differ 1998; 9:949-59.
36. Schumann RR, Kirschning CJ, Unbehaun A, Aberle HP, Knope HP, Lamping N, Ulevitch RJ, Herrmann F. The lipopolysaccharide-binding protein is a secretory class 1 acute phase protein whose gene is transcriptionally activated by APRF/STAT3 and other cytokine-inducible nuclear proteins. Mol Cell Biol 1996; 16:3490-503.
37. Brasier AR, Ron D, Tate JE, Habener JF. A family of constitutive C/EBP-like DNA binding proteins attenuate the IL-1α-induced, NF-κB mediated trans-activation of the angiotensinogen gene acute phase response element. EMBO J 1990; 9:3933-44.
38. Dunn SM, Coles LS, Lang RK, Gerondokis S, Vadas MA, Shannon MF. Requirement for nuclear factor (NF)-κB p65 and NF-interleukin-6 binding elements in the tumor necrosis factor response region of the granulocyte colony stimulating factor promoter. Blood 1994; 83:2469-79.
39. LeClair KP, Blanar MA, Sharp PA. The p50 subunit of NF-κB associates with the NF-IL6 transcription factor. Proc Natl Acad Sci USA 1992; 89:8145-9.
40. Stein B, Cogswell PC, Baldwin AS Jr. Functional and physical associations between NF-κB and C/EBP family members: a Re1 domain-bZIP interaction. Mol Cell Biol 1993; 13:3964-74.
41. Xia C, Cheshire JK, Patel H, Woo P. Cross-talk between transcription factors NF-κB and C/EBP in the transcriptional regulation of genes. Int J Biochem Cell Biol 1997; 29:1525-39.
42. Murphy C, Beckers J, Rüther U. Regulation of the human C-reactive protein gene in transgenic mice. J Biol Chem 1995; 270:704-8.
43. Smith CL, Hager GL. Transcriptional regulation of mammalian genes in vivo. A tale of two templates. J Biol Chem 1997; 272:27493-6.
44. Watchorn TM, Waddell ID, Dowidar N, Ross JA. Proteolysis-inducing factor regulates hepatic gene expression via the transcription factors NF-κB and STAT3. FASEB J 2001; 15:562-4.
45. Ohmori Y, Schreiber RD, Hamilton TA. Synergy between interferon-γ and tumor necrosis factor-α in transcriptional activation is mediated by cooperation between signal transducer and activator of transcription 1 and nuclear factor κB. J Biol Chem 1997; 272:14899-907.
46. Musikacharoen T, Matsuguchi T, Kikuchi T, Yoshikai Y. NF-κB and STATS play important roles in the regulation of mouse toll-like receptor 2 gene expression. J Immunol 2001; 166:4516-24.
47. Shen C, Stavnezer J. Interaction of STAT6 and NF-κB: direct association and synergistic activation of interleukin-4-induced transcription. Mol Cell Biol 1998; 18:3395-404.
48. Chen FE, Ghosh G. Regulation of DNA binding by Rel/NF-κB transcription factors: structural views. Oncogene 1999; 18:6845-52.
49. Lewis H, Kaszubska W, DeLamarter JF, Whelan J. Cooperativity between two NF-κB complexes, mediated by high-mobility-group protein I (Y), is essential for cytokine-induced expression of the E-selectin promoter. Mol Cell Biol 1994; 14:5701-9.
50. Brouillard F, Bouthier M, Leclerc T, Clement A, Baudouin-Legros M, Edelman A. NF-κB mediates up-regulation of CFTR gene expression in Calu-3 cells by interleukin-1β. J Biol Chem 2001; 276:9486-91.