The point mutation of tyrosine 759 of the IL-6 family cytokine receptor gp130 synergizes with HTLV-1 pX in promoting rheumatoid arthritis-like arthritis

International Immunology

Volumn 16, Issue 3, 2004, Pages 455-465

  Ishihara, Katsuhiko ^a,c   Sawa, Shin Ichiro ^c   Ikushima, Hideto ^c   Hirota, Seiichi ^c   Atsumi, Toru ^b   Kamimura, Daisuke ^c   Park, Sung Joo ^b   Murakami, Masaaki ^c   Kitamura, Yukihiko ^c   Iwakura, Yoichiro ^d   Hirano, Toshio ^a,b,c  

^a OSAKA UNIVERSITY   (Japan)

^b RIKEN   (Japan)

^c OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

Autoimmune disease, Knock in mouse; Rheumatoid arthritis; Tax

Indexed keywords

AUTOANTIBODY; CYTOKINE RECEPTOR; GLYCOPROTEIN GP 130; GLYCOPROTEIN P 15095; INTERLEUKIN 6; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MUTANT PROTEIN; TYROSINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; CONTROLLED STUDY; CROSSING OVER; DISEASE RESISTANCE; DISEASE SEVERITY; GRANULOCYTE; HUMAN T CELL LEUKEMIA VIRUS 1; HYPERGAMMAGLOBULINEMIA; IMMUNOPATHOLOGY; INCIDENCE; LYMPHADENOPATHY; LYMPHOID ORGAN; MEMORY CELL; MOUSE; MOUSE MUTANT; MOUSE STRAIN; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SPLENOMEGALY; SYMPTOMATOLOGY; T LYMPHOCYTE ACTIVATION; TRANSGENIC MOUSE;

ANIMALS; ANKLE JOINT; ANTIGENS, CD; ARTHRITIS, RHEUMATOID; CYTOKINE RECEPTOR GP130; DISEASE MODELS, ANIMAL; FLOW CYTOMETRY; GENES, PX; HUMAN T-LYMPHOTROPIC VIRUS 1; INTERLEUKIN-6; LYMPH NODES; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MYELOID CELLS; POINT MUTATION; SPLEEN; T-LYMPHOCYTE SUBSETS; TYROSINE;

EID: 12144289493     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/dxh045     Document Type: Article

References (29)

1. Firestein, G. S. 2003. Evolving concepts of rheumatoid arthritis. Nature 423:356.
2. Feldmann, M., Brennan F. M. and Maini, R. N. 1996. Role of cytokines in rheumatoid arthritis. Annu. Rev. Immunol. 14:397.
3. Feldmann, M. and Maini, R. N. 2001. Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned? Annu. Rev. Immunol. 19:163.
4. Hirano, T. 1998. Interleukin 6 and its receptor: ten years later. Int. Rev. Immunol. 16:249.
5. Hirano, T., Taga, T., Yasukawa, K., Nakajima, K., Nakano, N., Takatsuki, F., Shimizu, M., Murashima, X. Tsunasawa, S., Sakiyama, F., et al. 1987. Human B-cell differentiation factor defined by an anti-peptide antibody and its possible role in autoantibody production. Proc. Natl Acad. Sci. USA 84:228.
6. Hirano, T., Matsuda, T., Turner, M., Miyasaka, N., Buchan, G., Tang, B., Sato, K., Shimizu, M., Maini, R., Feldmann, M., et al. 1988. Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis. Eur. J. Immunol. 18:1797.
7. Ishihara, K. and Hirano, T, 2002. IL-6 in autoimmune disease and chronic inflammatory proliferative disease. Cytokine Growth Factor Rev. 13:357.
8. Alonzi. T., Fattori, E., Lazzaro, D., Costa, P., Probert, L., Kollias, G., De Benedetti, F., Poli, V. and Ciliberto, G. 1998. Interleukin 6 is required for the development of collagen-induced arthritis. J. Exp. Med. 187:461.
9. Ohshima, S., Saeki, Y., Mima, T., Sasai, M., Nishioka, K., Nomura, S., Kopf, M., Katada, Y., Tanaka, T., Suemura M. and Kishimoto, T. 1998. Interleukin 6 plays a key role in the development of antigen-induced arthritis. Proc. Natl Acad. Sci. USA 95:8222.
10. Sasai, M., Saeki, Y., Ohshima, S., Nishioka, K., Mima, T., Tanaka, T., Katada, Y., Yoshizaki, K., Suemura, M. and Kishimoto, T. 1999. Delayed onset and reduced severity of collagen-induced arthritis in interleukin-6-deficient mice. Arthritis Rheum. 42:1635.
11. Atsumi, T., Ishihara, K., Kamimura, D., Ikushima, H., Ohtani, T., Hirota, S., Kobayashi, H., Park, S, J., Saeki, Y., Kitamura, Y. and Hirano, T. 2002. A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis. J. Exp. Med. 196:979.
12. Hirano, T., Ishihara, K. and Hibi, M. 2000. Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors. Oncogene 19:2548.
13. Kamimura, D., Ishihara, K. and Hirano, T. 2003. IL-6 signal transduction and its physiological roles: the signal orchestration model. Rev. Physiol. Biochem. Pharmacol. 149:1.
14. Ohtani, T., Ishihara, K., Atsumi, T., Nishida, K., Kaneko, Y., Miyata, T., Itoh, S., Narimatsu, M., Maeda, H., Fukada, T., Itoh, M., Okano, H., Hibi, M. and Hirano, T. 2000. Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses. Immunity 12:95.
15. Sodroski, J. G., Rosen, C. A. and Haseltine, W. A. 1984. Trans-acting transcriptional activation of the long terminal repeat of human T lymphotropic viruses in infected cells. Science 225:381.
16. Fujisawa, J., Seiki. M., Sato, M. and Yoshida, M. 1986. A transcriptional enhancer sequence of HTLV-I is responsible for trans-activation mediated by p40 chi HTLV-I. EMBO J. 5:713.
17. Maruyama, M., Shibuya, H., Harada, H., Hatakeyama, M., Seiki, M., Fujita, T., Inoue, J., Yoshida, M. and Taniguchi, T. 1987. Evidence for aberrant activation of the interleukin-2 autocrine loop by HTLV-1-encoded p40x and T3/Ti complex triggering. Cell 48:343.
18. Muraoka, O., Kaisho, T., Tanabe, M. and Hirano, T. 1993. Transcriptional activation of the interleukin-6 gene by HTLV-1 p40tax through an NF-kappa B-like binding site. Immunol. Lett. 37:159.
19. Inoue, J., Seiki, M., Taniguchi, T., Tsuru, S. and Yoshida, M. 1986. Induction of interleukin 2 receptor gene expression by p40x encoded by human T-cell leukemia virus type 1. EMBO J. 5:2883.
20. Fujii, M., Niki, T., Mori, T., Matsuda, T., Matsul, M., Nomura, N. and Seiki, M. 1991. HTLV-1 Tax induces expression of various immediate early serum responsive genes. Oncogene 6:1023.
21. Kitajima, I., Yamamoto, K., Sato, K., Nakajima, Y., Nakajima, T., Maruyama, I., Osame, M. and Nishioka, K. 1991. Detection of human T cell lymphotropic virus type I proviral DNA and its gene expression in synovial cells in chronic inflammatory arthropathy. J. Clin. Invest. 88:1315.
22. Iwakura, Y., Tosu, M., Yoshida, E., Takiguchi, M., Sato, K., Kitajima, I., Nishioka, K., Yamamoto, K., Takeda, T., Hatanaka, M., et al. 1991. Induction of inflammatory arthropathy resembling rheumatoid arthritis in mice transgenic for HTLV-I. Science 253:1026.
23. Kishi, S., Saijyo, S., Arai, M., Karasawa, S., Ueda, S., Kannagi, M., Iwakura, Y., Fujii, M. and Yonehara, S. 1997. Resistance to fas-mediated apoptosis of peripheral T cells in human T lymphocyte virus type I (HTLV-I) transgenic mice with autoimmune arthropathy. J. Exp. Med. 186:57.
24. Iwakura, Y., Itagaki, K., Ishitsuka, C., Yamasalki, Y., Matsuzawa, A., Yonehara, S., Karasawa, S., Ueda, S. and Saijo, S. 1998. The development of autoimmune inflammatory arthropathy in mice transgenic for the human T cell leukemia virus type-1 env-pX region is not dependent on H-2 haplotypes and modified by the expression levels of Fas antigen. J. Immunol. 161:6592.
25. Kopf, M., Ramsay, A., Brombacher, F., Baumann, H., Freer, G., Galanos, C., Gutierrez-Ramos, J. C. and Kohler, G. 1995. Pleiotropic defects of IL-6-deficient mice including early hematopoiesis, T and B cell function, and acute phase responses. Ann. NY Acad. Sci. 762:308.
26. Itoh, M., Ishihara, K., Hiroi, T., Lee, B. O., Maeda, H., Iijima, H., Yanagita, M., Kiyono, H. and Hirano, T. 1998. Deletion of bone marrow stromal cell antigen-1 (CD157) gene impaired systemic thymus independent-2 antigen-induced IgG3, and mucosal TD antigen-elicited IgA responses. J. Immunol. 161:3974.
27. Ishihara, K., Kobune, Y., Okuyama, Y., Itoh, M., Lee, B. O., Muraoka, O. and Hirano, T. 1996. Stage-specific expression of mouse BST-1/BP-3 on the early B and T cell progenitors prior to gene rearrangement of antigen receptor. Int. Immunol. 8:1395.
28. Betz, U. A., Bloch, W., van den Broek, M., Yoshida, K., Taga, T., Kishimoto, T., Addicks, K., Rajewsky, K. and Muller, W. 1998. Postnatally induced inactivation of gp130 in mice results in neurological, cardiac, hematopoietic, immunological, hepatic, and pulmonary defects. J. Exp. Med. 188:1955.
29. Mellman, I. and Steinman, R. M. 2001. Dendritic cells: specialized and regulated antigen processing machines. Cell 106:255.