A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis

Journal of Experimental Medicine

Volumn 196, Issue 7, 2002, Pages 979-990

  Atsumi, Toru ^a,c   Ishihara, Katsuhiko ^a,b   Kamimura, Daisuke ^a   Ikushima, Hideto ^a   Ohtani, Takuya ^a   Hirota, Seiichi ^a   Kobayashi, Hideyuki ^d   Park, Sung Joo ^a   Saeki, Yukihiko ^a   Kitamura, Yukihiko ^a   Hirano, Toshio ^a,b,c,e  

^a GRADUATE SCHOOL OF MEDICINE   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c RIKEN Center for Integrative Medical Sciences   (Japan)

^d KOWA COMPANY LTD   (Japan)

^e OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Gp130; IL 6; Rheumatoid arthritis; SHP 2; STAT 3

Indexed keywords

AUTOANTIBODY; CYTOKINE RECEPTOR; FAS LIGAND; GLYCOPROTEIN GP 130; INTERLEUKIN 6; PROTEIN TYROSINE PHOSPHATASE; STAT3 PROTEIN; TYROSINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNE DISEASE; BINDING SITE; BONE MARROW CELL; CONTROLLED STUDY; FEMALE; IMMUNOLOGICAL TOLERANCE; MALE; MEMORY CELL; MOUSE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SRC HOMOLOGY DOMAIN; T LYMPHOCYTE ACTIVATION;

AMINO ACID SUBSTITUTION; ANIMALS; ANTIBODY FORMATION; APOPTOSIS; ARTHRITIS, EXPERIMENTAL; BASE SEQUENCE; BINDING SITES; BONE AND BONES; CD4-POSITIVE T-LYMPHOCYTES; DNA PRIMERS; ENTEROTOXINS; LYMPH NODES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; POINT MUTATION; POLYMERASE CHAIN REACTION; PROTEIN SUBUNITS; RECEPTORS, INTERLEUKIN-6; STAPHYLOCOCCUS AUREUS; SUPERANTIGENS; T-LYMPHOCYTES; TYROSINE;

EID: 0037037586     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20020619     Document Type: Article

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