Interleukin-17A promotes rheumatoid arthritis synoviocytes migration and invasion under hypoxia by increasing MMP2 and MMP9 expression through NF-κB/HIF-1α pathway

Molecular Immunology

Volumn 53, Issue 3, 2013, Pages 227-236

  Li, Guoqing ^a   Zhang, Yu ^a   Qian, Yayun ^a   Zhang, Hua ^a   Guo, Shiyu ^b   Sunagawa, Masataka ^b   Hisamitsu, Tadashi ^b   Liu, Yanqing ^a  

^a YANGZHOU UNIVERSITY   (China)

^b SHOWA UNIVERSITY   (Japan)

Author keywords

Hypoxia; Interleukin 17A; Invasion; Matrix metalloproteinase; Rheumatoid arthritis; Synoviocytes

Indexed keywords

3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; GELATINASE A; GELATINASE B; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 17; LIFICIGUAT; SMALL INTERFERING RNA;

ARTICLE; CELL HYPOXIA; CELL INVASION; CELL MIGRATION; CELL MOTILITY; CELL VIABILITY; CONTROLLED STUDY; ENZYME INHIBITION; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; HUMAN TISSUE; IMMUNOPATHOGENESIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS; SYNOVIOCYTE;

ARTHRITIS, RHEUMATOID; BASE SEQUENCE; CELL HYPOXIA; CELL MOVEMENT; CELLS, CULTURED; EPITHELIAL-MESENCHYMAL TRANSITION; GENE KNOCKDOWN TECHNIQUES; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INTERLEUKIN-17; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; NF-KAPPA B; RECOMBINANT PROTEINS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SYNOVIAL MEMBRANE;

EID: 84865657365     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2012.08.018     Document Type: Article

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