Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

Nature Communications

Volumn 2, Issue , 2014, Pages

  Jurk, Diana ^a   Wilson, Caroline ^a   Passos, João F ^a   Oakley, Fiona ^a   Correia Melo, Clara ^a   Greaves, Laura ^a   Saretzki, Gabriele ^a   Fox, Chris ^a   Lawless, Conor ^a   Anderson, Rhys ^a   Hewitt, Graeme ^a   Pender, Sylvia L F ^b   Fullard, Nicola ^a   Nelson, Glyn ^a   Mann, Jelena ^a   Van De Sluis, Bart ^c   Mann, Derek A ^a   Von Zglinicki, Thomas ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^c UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BUTYLATED HYDROXYANISOLE; CYCLOOXYGENASE 2; IBUPROFEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; REACTIVE OXYGEN METABOLITE; NFKB1 PROTEIN, MOUSE; PTGS2 PROTEIN, RAT;

AGING; CHROMOSOME; GENE EXPRESSION; REGROWTH; RODENT; SENESCENCE;

ADULT; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOCRINE EFFECT; CHROMOSOME DISORDER; CHRONIC INFLAMMATION; CONTROLLED STUDY; DISEASE COURSE; DNA DAMAGE; FEEDBACK SYSTEM; FIBROBLAST; IN VIVO STUDY; INTESTINE CRYPT; LIFESPAN; LIVER CELL; MALE; MOUSE; NONHUMAN; PARACRINE SIGNALING; QUANTITATIVE ANALYSIS; SENESCENCE; TELOMERE; TISSUE REGENERATION; ANIMAL; CELL AGING; CHRONIC DISEASE; GENETICS; IMMUNOLOGY; INFLAMMATION; KNOCKOUT MOUSE; LIVER REGENERATION; METABOLISM; PREMATURE AGING; REGENERATION; TELOMERE HOMEOSTASIS;

AGING, PREMATURE; ANIMALS; CELL AGING; CHRONIC DISEASE; CYCLOOXYGENASE 2; DNA DAMAGE; FEEDBACK, PHYSIOLOGICAL; FIBROBLASTS; INFLAMMATION; LIVER REGENERATION; MICE; MICE, KNOCKOUT; NF-KAPPA B; NF-KAPPA B P50 SUBUNIT; REACTIVE OXYGEN SPECIES; REGENERATION; TELOMERE HOMEOSTASIS;

EID: 84903485542     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms5172     Document Type: Article

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