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Volumn 461, Issue 7267, 2009, Pages 1084-1091

Pten in stromal fibroblasts suppresses mammary epithelial tumours

(27)  Trimboli, Anthony J a   Cantemir Stone, Carmen Z a   Li, Fu a   Wallace, Julie A a   Merchant, Anand a   Creasap, Nicholas a   Thompson, John C a   Caserta, Enrico a   Wang, Hui a   Chong, Jean Leon a   Naidu, Shan a   Wei, Guo a   Sharma, Sudarshana M a   Stephens, Julie A a   Fernandez, Soledad A a   Gurcan, Metin N a   Weinstein, Michael B a   Barsky, Sanford H a,g,h   Yee, Lisa a   Rosol, Thomas J a   more..


Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; TRANSCRIPTION FACTOR ETS 2;

EID: 70350510924     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature08486     Document Type: Article
Times cited : (450)

References (49)
  • 1
    • 0037052448 scopus 로고    scopus 로고
    • Stromal effects on mammary gland development and breast cancer
    • Wiseman, B. S. & Werb. Z. Stromal effects on mammary gland development and breast cancer. Science 296,1046-1049 (2002).
    • (2002) Science , vol.296 , pp. 1046-1049
    • Wiseman, B.S.1    Werb, Z.2
  • 2
    • 33748967069 scopus 로고    scopus 로고
    • Of extracellular matrix, scaffolds, and signaling: Tissue architecture regulates development, homeostasis, and cancer
    • Nelson, C. M. & Bissell, M. J. Of extracellular matrix, scaffolds, and signaling: tissue architecture regulates development, homeostasis, and cancer. Annu. Rev. Cell Dev. Biol. 22, 287-309 (2006).
    • (2006) Annu. Rev. Cell Dev. Biol. , vol.22 , pp. 287-309
    • Nelson, C.M.1    Bissell, M.J.2
  • 3
    • 8144228952 scopus 로고    scopus 로고
    • Friends or foes - Bipolar effects of the tumour stroma in cancer
    • Mueller. M. M. & Fusenig. N. E. Friends or foes - bipolar effects of the tumour stroma in cancer. Nature Rev. Cancer 4, 839-849 (2004).
    • (2004) Nature Rev. Cancer , vol.4 , pp. 839-849
    • Mueller, M.M.1    Fusenig, N.E.2
  • 4
    • 33645322443 scopus 로고    scopus 로고
    • Pregnancy-associated breast cancer and metastasis
    • Schedin, P. Pregnancy-associated breast cancer and metastasis. Nature Rev. Cancere, 281-291 (2006).
    • (2006) Nature Rev. Cancere , pp. 281-291
    • Schedin, P.1
  • 5
    • 20444386530 scopus 로고    scopus 로고
    • Coevolution of cancer and stromal cellular responses
    • DOI 10.1016/j.ccr.2005.05.019, PII S1535610805001625
    • Littlepage. L E., Egeblad. M. & Werb, Z. Coevolution of cancer and stromal cellular responses. Cancer Cell 7, 499-500 (2005). (Pubitemid 40799241)
    • (2005) Cancer Cell , vol.7 , Issue.6 , pp. 499-500
    • Littlepage, L.E.1    Egeblad, M.2    Werb, Z.3
  • 6
    • 9244227134 scopus 로고    scopus 로고
    • Stromal fibroblasts in cancer initiation and progression
    • DOI 10.1038/nature03096
    • Bhowmick, N. A., Neilson, E. G. & Moses, H. L Stromal fibroblasts in cancer initiation and progression. Nature 432, 332-337 (2004). (Pubitemid 39551661)
    • (2004) Nature , vol.432 , Issue.7015 , pp. 332-337
    • Bhowmick, N.A.1    Neilson, E.G.2    Moses, H.L.3
  • 8
    • 33644513730 scopus 로고    scopus 로고
    • Beyond PTEN mutations: The PI3K pathway as an integrator of multiple inputs during tumorigenesis
    • DOI 10.1038/nrc1819, PII N1819
    • Cully, M., You, H., Levine, A. J. & Mak, T. W. Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nature Rev. Cancer 6,184-192 (2006). (Pubitemid 43292562)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.3 , pp. 184-192
    • Cully, M.1    You, H.2    Levine, A.J.3    Mak, T.W.4
  • 10
    • 0032506011 scopus 로고    scopus 로고
    • The lipid phosphatase activity of PTEN is critical for its tumor supressor function
    • Myers, M. P. et al. The lipid phosphatase activity of PTEN is critical for its tumor supressor function. Proc. Nati Acad. Sci. USA 95,13513-13518 (1998).
    • (1998) Proc. Nati Acad. Sci. USA , vol.95 , pp. 13513-13518
    • Myers, M.P.1
  • 12
    • 43049128529 scopus 로고    scopus 로고
    • Tenets of PTEN tumor suppression
    • Salmena, L, Carracedo, A. & Pandolfi, P. P. Tenets of PTEN tumor suppression. Cell 133, 403-414 (2008).
    • (2008) Cell , vol.133 , pp. 403-414
    • Salmena, L.1    Carracedo, A.2    Pandolfi, P.P.3
  • 13
    • 51849096491 scopus 로고    scopus 로고
    • The roles of PTEN in development, physiology and tumorigenesis in mouse models: A tissue-by-tissue survey
    • Knobbe, C. B., Lapin, V., Suzuki, A. & Mak, T. W. The roles of PTEN in development, physiology and tumorigenesis in mouse models: a tissue-by-tissue survey. Oncogene 27, 5398-5415 (2008).
    • (2008) Oncogene , vol.27 , pp. 5398-5415
    • Knobbe, C.B.1    Lapin, V.2    Suzuki, A.3    Mak, T.W.4
  • 14
    • 0031870959 scopus 로고    scopus 로고
    • Pten is essential for embryonic development and tumour suppression
    • DOI 10.1038/1235
    • Di Cristofano, A., Pesce, B., Cordon-Cardo, C. & Pandolfi, P. P. Pten is essential for embryonic development and tumour suppression. Nature Genet 19, 348-355 (1998). (Pubitemid 28357906)
    • (1998) Nature Genetics , vol.19 , Issue.4 , pp. 348-355
    • Di, C.A.1    Pesce, B.2    Cordon-Cardo, C.3    Pandolfi, P.P.4
  • 15
    • 38849093994 scopus 로고    scopus 로고
    • Direct evidence for epithelial-mesenchymal transitions in breast cancer
    • Trimboli, A. J. et al. Direct evidence for epithelial-mesenchymal transitions in breast cancer. Cancer Res. 68, 937-945 (2008).
    • (2008) Cancer Res. , vol.68 , pp. 937-945
    • Trimboli, A.J.1
  • 16
    • 0026472124 scopus 로고
    • Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease
    • Guy. C. T. et al. Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease. Proc Natl Acad. Sci. USA 89, 10578-10582 (1992).
    • (1992) Proc Natl Acad. Sci. USA , vol.89 , pp. 10578-10582
    • Guy, C.T.1
  • 18
    • 0034724314 scopus 로고    scopus 로고
    • Amplification of the neu/erbB-2 oncogene in a mouse model of mammary tumorigenesis
    • Andrechek, E. R. et al. Amplification of the neu/erbB-2 oncogene in a mouse model of mammary tumorigenesis. Proc. Natl Acad. Sci. USA 97, 3444-3449 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 3444-3449
    • Andrechek, E.R.1
  • 19
    • 0037076342 scopus 로고    scopus 로고
    • Initiating oncogenic event determines gene-expression patterns of human breast cancer models
    • Desai, K. V. et al. Initiating oncogenic event determines gene-expression patterns of human breast cancer models. Proc. Natl Acad. Sci. USA 99,6967-6972 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 6967-6972
    • Desai, K.V.1
  • 20
    • 0038054341 scopus 로고    scopus 로고
    • PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
    • Mootha, V. K. et al. PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nature Genet 34, 267-273 (2003).
    • (2003) Nature Genet , vol.34 , pp. 267-273
    • Mootha, V.K.1
  • 21
    • 0038005018 scopus 로고    scopus 로고
    • DAVID: Database for annotation, visualization, and integrated discovery
    • Dennis, G., Jr et al. DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol. 4, 3 (2003).
    • (2003) Genome Biol. , vol.4 , pp. 3
    • Dennis Jr., G.1
  • 22
    • 61449172037 scopus 로고    scopus 로고
    • Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
    • Huang, D. W., Sherman, B.T.&Lempicki, R. A. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nature Protocols 4, 44-57 (2009).
    • (2009) Nature Protocols , vol.4 , pp. 44-57
    • Huang, D.W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 23
    • 0037098951 scopus 로고    scopus 로고
    • PTEN blocks insulin-mediated ETS-2 phosphorylation through MAP kinase, independently of the phosphoinositide 3-kinase pathway
    • Weng, L P., Brown, J. L, Baker, K. M., Ostrowski, M. C. & Eng, C. PTEN blocks insu I in-mediated ETS-2 phosphorylation through MAP kinase, independently of the phosphoinositide 3-kinase pathway. Hum. Mol. Genet 11,1687-1696 (2002). (Pubitemid 34812090)
    • (2002) Human Molecular Genetics , vol.11 , Issue.15 , pp. 1687-1696
    • Weng, L.-P.1    Brown, J.L.2    Baker, K.M.3    Ostrowski, M.C.4    Eng, C.5
  • 24
    • 0031812160 scopus 로고    scopus 로고
    • Persistent activation of mitogen-activated protein kinases p42 and p44 and ets-2 phosphorylation in response to colony-stimulating factor 1/cfms signaling
    • Fowles, L. F. et al. Persistent activation of mitogen-activated protein kinases p42 and p44 and ets-2 phosphorylation in response to colony-stimulating factor 1/cfms signaling. Mol. Cell. Biol. 18, 5148-5156 (1998).
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 5148-5156
    • Fowles, L.F.1
  • 25
    • 0030974039 scopus 로고    scopus 로고
    • Rapid phosphorylation of Ets-2 accompanies mitogenactivated protein kinase activation and the induction of heparin-binding epidermal growth factor gene expression by oncogenic Raf-1
    • McCarthy, S. A. et al. Rapid phosphorylation of Ets-2 accompanies mitogenactivated protein kinase activation and the induction of heparin-binding epidermal growth factor gene expression by oncogenic Raf-1. Mol. Cell. Biol. 17, 2401-2412 (1997).
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 2401-2412
    • McCarthy, S.A.1
  • 27
    • 0032479139 scopus 로고    scopus 로고
    • The Ets-1 and Ets-2 transcription factors activate the promoters for invasion-associated urokinase and collagenase genes in response to epidermal growth factor
    • Watabe, T. et al. The Ets-1 and Ets-2 transcription factors activate the promoters for invasion-associated urokinase and collagenase genes in response to epidermal growth factor. Int. J. Cancerll, 128-137 (1998).
    • (1998) Int. J. Cancerll , pp. 128-137
    • Watabe, T.1
  • 29
    • 30444432840 scopus 로고    scopus 로고
    • Local proteolytic activity in tumor cell invasion and metastasis
    • Ludwig, T. Local proteolytic activity in tumor cell invasion and metastasis. Bioessays 27,1181-1191 (2005).
    • (2005) Bioessays , vol.27 , pp. 1181-1191
    • Ludwig, T.1
  • 30
    • 70349260738 scopus 로고    scopus 로고
    • Etsl and Ets2 are required for endothelial cell survival during embryonic angiogenesis
    • Wei, G. et al. Etsl and Ets2 are required for endothelial cell survival during embryonic angiogenesis. Blood 114,1123-1130 (2009).
    • (2009) Blood , vol.114 , pp. 1123-1130
    • Wei, G.1
  • 31
    • 0142244181 scopus 로고    scopus 로고
    • Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases
    • Lin, E. Y. et al. Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases. Am. J. Pathol. 163,2113-2126 (2003).
    • (2003) Am. J. Pathol. , vol.163 , pp. 2113-2126
    • Lin, E.Y.1
  • 32
    • 0032079317 scopus 로고    scopus 로고
    • Defective trophoblast function in mice with a targeted mutation of Ets2
    • Yamamoto, H. et al. Defective trophoblast function in mice with a targeted mutation of Ets2. Genes Dev. 12,1315-1326 (1998).
    • (1998) Genes Dev. , vol.12 , pp. 1315-1326
    • Yamamoto, H.1
  • 33
    • 22344437713 scopus 로고    scopus 로고
    • Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors
    • DOI 10.1083/jcb.200409115
    • Lee. S., Jilani, S. M., Nikolova, G. V., Carpizo, D. & Iruela-Arispe, M. L. Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors. J. Cell Biol. 169, 681-691 (2005). (Pubitemid 41002860)
    • (2005) Journal of Cell Biology , vol.169 , Issue.4 , pp. 681-691
    • Lee, S.1    Jilan, S.M.2    Nikolova, G.V.3    Carpizo, D.4    Luisa, I.-A.5
  • 34
    • 0027466849 scopus 로고
    • High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis
    • DOI 10.1016/0092-8674(93)90573-9
    • Millauer, B. et al. High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell 72, 835-846 (1993). (Pubitemid 23110226)
    • (1993) Cell , vol.72 , Issue.6 , pp. 835-846
    • Millauer, B.1    Wizigmann-Voos, S.2    Schnurch, H.3    Martinez, R.4    Moller, N.P.H.5    Risau, W.6    Ullrich, A.7
  • 35
    • 12844264070 scopus 로고    scopus 로고
    • Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice
    • Sakurai, Y., Ohgimoto, K., Kataoka, Y., Yoshida, N. & Shibuya, M. Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice. Proc. Natl Acad. Sci. USA 102,1076-1081 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 1076-1081
    • Sakurai, Y.1    Ohgimoto, K.2    Kataoka, Y.3    Yoshida, N.4    Shibuya, M.5
  • 36
    • 12844271532 scopus 로고    scopus 로고
    • Conformational HER-2/neu B-cell epitope peptide vaccine designed to incorporate two native disulfide bonds enhances tumor cell binding and antitumor activities
    • Dakappagari, N. K. et al. Conformational HER-2/neu B-cell epitope peptide vaccine designed to incorporate two native disulfide bonds enhances tumor cell binding and antitumor activities. J. Biol. Chem. 280, 54-63 (2005).
    • (2005) J. Biol. Chem. , vol.280 , pp. 54-63
    • Dakappagari, N.K.1
  • 39
    • 37549020704 scopus 로고    scopus 로고
    • Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair
    • Saal, L. H. et al. Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair. Nature Genet 40,102-107 (2008).
    • (2008) Nature Genet , vol.40 , pp. 102-107
    • Saal, L.H.1
  • 40
    • 34250687198 scopus 로고    scopus 로고
    • Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity
    • Saal, L. H. et al. Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity. Proc. Natl Acad. Sci. USA 104,7564-7569 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 7564-7569
    • Saal, L.H.1
  • 41
    • 27144506171 scopus 로고    scopus 로고
    • Ets2-dependent microenvironmental support of mouse mammary tumors
    • DOI 10.1038/sj.onc.1208856, PII 1208856
    • Tynan, J. A., Wen, F., Muller, W. J. & Oshima, R. G. Ets2-dependent microenvironmental support of mouse mammary tumors. Oncogene 24, 6870-6876 (2005). (Pubitemid 41509410)
    • (2005) Oncogene , vol.24 , Issue.46 , pp. 6870-6876
    • Tynan, J.A.1    Wen, F.2    Muller, W.J.3    Oshima, R.G.4
  • 43
    • 41149147258 scopus 로고    scopus 로고
    • Heterologous tissue culture expression signature predicts human breast cancer prognosis
    • Park, E. S. et al. Heterologous tissue culture expression signature predicts human breast cancer prognosis. PLoS One 2, e145 (2007).
    • (2007) PLoS One , vol.2
    • Park, E.S.1
  • 44
    • 21744453318 scopus 로고    scopus 로고
    • ERK phosphorylation is linked to VEGFR2 expression and Ets-2 phosphorylation in breast cancer and is associated with tamoxifen treatment resistance and small tumours with good prognosis
    • DOI 10.1038/sj.onc.1208626
    • Svensson, S. et al. ERK phosphorylation is linked to VEGFR2 expression and Ets-2 phosphorylation in breast cancer and is associated with tamoxifen treatment resistance and small tumours with good prognosis. Oncogene 24,4370-4379 (2005). (Pubitemid 40961760)
    • (2005) Oncogene , vol.24 , Issue.27 , pp. 4370-4379
    • Svensson, S.1    Jirstrom, K.2    Ryden, L.3    Roos, G.4    Emdin, S.5    Ostrowski, M.C.6    Landberg, G.7
  • 45
    • 0034467058 scopus 로고    scopus 로고
    • Activation of synovial fibroblasts in rheumatoid arthritis: Lack of expression of the tumour suppressor PTEN at sites of invasive growth and destruction
    • DOI 10.1186/ar69
    • Pap, T. et al. Activation of synovial fibroblasts in rheumatoid arthritis: lack of Expression of the tumour suppressor PTEN at sites of invasive growth and destruction. Arthritis Res. 2, 59-64 (2000). (Pubitemid 32223701)
    • (2000) Arthritis Research , vol.2 , Issue.1 , pp. 59-64
    • Pap, T.1    Franz, J.K.2    Hummel, K.M.3    Jeisy, E.4    Gay, R.5    Gay, S.6
  • 46
    • 30344485686 scopus 로고    scopus 로고
    • Negative regulation of myofibroblast differentiation by PTEN phosphatase and tensin homolog deleted on chromosome 10
    • White, E. S. et al. Negative regulation of myofibroblast differentiation by PTEN (phosphatase and tensin homolog deleted on chromosome 10). Am. J. Respir. Crit Care Med. 173,112-121 (2006).
    • (2006) Am. J. Respir. Crit Care Med. , vol.173 , pp. 112-121
    • White, E.S.1
  • 47
    • 0036545993 scopus 로고    scopus 로고
    • Oxidative processes in the brain and non-neuronal tissues as biomarkers of Alzheimer's disease
    • Gibson, G. E & Huang, H. M. Oxidative processes in the brain and non-neuronal tissues as biomarkers of Alzheimer's disease. Front Biosci. 7, d1007-d1015 (2002).
    • (2002) Front Biosci. , vol.7
    • Gibson, G.E.1    Huang, H.M.2
  • 48
    • 0031915998 scopus 로고    scopus 로고
    • Prognostic and predictive factors in breast cancer by immunohistochemical analysis
    • Allred. D. C, Harvey, J. M., Berardo, M. & Clark, G. M. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod. Pathol. 11, 155-168 (1998).
    • (1998) Mod. Pathol. , vol.11 , pp. 155-168
    • Allred, D.C.1    Harvey, J.M.2    Berardo, M.3    Clark, G.M.4
  • 49
    • 0022652256 scopus 로고
    • A simplified method for passage and long-term growth of human mammary epithelial cells
    • Soule, H. D. & McGrath. C. M. A simplified method for passage and long-term growth of human mammary epithelial cells. In Vitro Cell. Dev. Biol. 22,6-12 (1986).
    • (1986) In Vitro Cell. Dev. Biol. , vol.22 , pp. 6-12
    • Soule, H.D.1    McGrath, C.M.2


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