-
1
-
-
84899438176
-
Colorectal cancer statistics, 2014
-
Siegel, R.; Desantis, C.; Jemal, A. Colorectal cancer statistics, 2014. CA Cancer J. Clin., 2014, 64(2), 104-117.
-
(2014)
CA Cancer J. Clin.
, vol.64
, Issue.2
, pp. 104-117
-
-
Siegel, R.1
Desantis, C.2
Jemal, A.3
-
2
-
-
78049332872
-
Colorectal cancer epidemiology: Incidence, mortality, survival, and risk factors
-
Haggar, F.A.; Boushey, R.P. Colorectal cancer epidemiology: incidence, mortality, survival, and risk factors. Clin. Colon Rectal Surg., 2009, 22(4), 191-197.
-
(2009)
Clin. Colon Rectal Surg.
, vol.22
, Issue.4
, pp. 191-197
-
-
Haggar, F.A.1
Boushey, R.P.2
-
3
-
-
85047177220
-
Colorectal cancer Facts and Figures
-
American Cancer Society. Colorectal cancer Facts and Figures, Atlanta: American Cancer Society, 2012.
-
(2012)
Atlanta: American Cancer Society
-
-
-
4
-
-
0347492085
-
-
1975-2012; National Cancer Institute: Bethesda, MD
-
Howlader, N.N.A.; Krapcho, M.; Garshell, J.; Miller, D.; Altekruse, S.F.; Kosary, C.L.; Yu, M.; Ruhl, J.; Tatalovich, Z.; Mariotto, A.; Lewis, D.R.; Chen, H.S.; Feuer, E.J.; Cronin, K.A. SEER Cancer Statistics Review, 1975-2012; National Cancer Institute: Bethesda, MD, 2015.
-
(2015)
SEER Cancer Statistics Review
-
-
Howlader, N.N.A.1
Krapcho, M.2
Garshell, J.3
Miller, D.4
Altekruse, S.F.5
Kosary, C.L.6
Yu, M.7
Ruhl, J.8
Tatalovich, Z.9
Mariotto, A.10
Lewis, D.R.11
Chen, H.S.12
Feuer, E.J.13
Cronin, K.A.14
-
5
-
-
85047211276
-
-
SEER Cancer Statistics Factsheets: Colon and Rectum Cancer; National Cancer Institute: Bethesda, MD
-
Factsheets, S.C. SEER Cancer Statistics Factsheets: Colon and Rectum Cancer; National Cancer Institute: Bethesda, MD, 2015.
-
(2015)
-
-
Factsheets, S.C.1
-
6
-
-
70249110476
-
Rates and patterns of recurrence following curative intent surgery for colorectal liver metastasis: An international multi-institutional analysis of 1669 patients
-
de Jong, M.C.; Pulitano, C.; Ribero, D.; Strub, J.; Mentha, G.; Schulick, R.D.; Choti, M.A.; Aldrighetti, L.; Capussotti, L.; Pawlik, T.M. Rates and patterns of recurrence following curative intent surgery for colorectal liver metastasis: an international multi-institutional analysis of 1669 patients. Ann. Surg., 2009, 250(3), 440-448.
-
(2009)
Ann. Surg.
, vol.250
, Issue.3
, pp. 440-448
-
-
de Jong, M.C.1
Pulitano, C.2
Ribero, D.3
Strub, J.4
Mentha, G.5
Schulick, R.D.6
Choti, M.A.7
Aldrighetti, L.8
Capussotti, L.9
Pawlik, T.M.10
-
7
-
-
84927173136
-
Successes and limitations of targeted cancer therapy in colon cancer
-
Köhne, C.H. Successes and limitations of targeted cancer therapy in colon cancer. Prog. Tumor Res., 2014, 41, 36-50.
-
(2014)
Prog. Tumor Res.
, vol.41
, pp. 36-50
-
-
Köhne, C.H.1
-
8
-
-
79955977887
-
Protein kinase Cα signaling regulates inhibitor of DNA binding 1 in the intestinal epithelium
-
Hao, F.; Pysz, M.A.; Curry, K.J.; Haas, K.N.; Seedhouse, S.J.; Black, A.R.; Black, J.D. Protein kinase Cα signaling regulates inhibitor of DNA binding 1 in the intestinal epithelium. J. Biol. Chem., 2011, 286(20), 18104-18117.
-
(2011)
J. Biol. Chem.
, vol.286
, Issue.20
, pp. 18104-18117
-
-
Hao, F.1
Pysz, M.A.2
Curry, K.J.3
Haas, K.N.4
Seedhouse, S.J.5
Black, A.R.6
Black, J.D.7
-
9
-
-
84905860583
-
Differential regulation of cyclin D1 expression by protein kinase C α and ϵ signaling in intestinal epithelial cells
-
Pysz, M.A.; Hao, F.; Hizli, A.A.; Lum, M.A.; Swetzig, W.M.; Black, A.R.; Black, J.D. Differential regulation of cyclin D1 expression by protein kinase C α and ϵ signaling in intestinal epithelial cells. J. Biol. Chem., 2014, 289(32), 22268-22283.
-
(2014)
J. Biol. Chem.
, vol.289
, Issue.32
, pp. 22268-22283
-
-
Pysz, M.A.1
Hao, F.2
Hizli, A.A.3
Lum, M.A.4
Swetzig, W.M.5
Black, A.R.6
Black, J.D.7
-
10
-
-
84897430074
-
Ubiquitin-like (UBX)-domain-containing protein, UBXN-2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells
-
Sane, S.; Abdullah, A.; Boudreau, D.A.; Autenried, R.K.; Gupta, B.K.; Wang, X.; Wang, H.; Schlenker, E.H.; Zhang, D.; Telleria, C.; Huang, L.; Chauhan, S.C.; Rezvani, K. Ubiquitin-like (UBX)-domain-containing protein, UBXN-2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells. Cell Death Dis., 2014, 5, e1118.
-
(2014)
Cell Death Dis
, vol.5
-
-
Sane, S.1
Abdullah, A.2
Boudreau, D.A.3
Autenried, R.K.4
Gupta, B.K.5
Wang, X.6
Wang, H.7
Schlenker, E.H.8
Zhang, D.9
Telleria, C.10
Huang, L.11
Chauhan, S.C.12
Rezvani, K.13
-
11
-
-
0038389383
-
Differential, stage-dependent expression of Hsp70, Hsp110 and Bcl-2 in colorectal cancer
-
Hwang, T.S.; Han, H.S.; Choi, H.K.; Lee, Y.J.; Kim, Y.J.; Han, M.Y.; Park, Y.M. Differential, stage-dependent expression of Hsp70, Hsp110 and Bcl-2 in colorectal cancer. J. Gastroenterol. Hepatol., 2003, 18(6), 690-700.
-
(2003)
J. Gastroenterol. Hepatol.
, vol.18
, Issue.6
, pp. 690-700
-
-
Hwang, T.S.1
Han, H.S.2
Choi, H.K.3
Lee, Y.J.4
Kim, Y.J.5
Han, M.Y.6
Park, Y.M.7
-
12
-
-
33646241764
-
Heat shock protein 70 neutralization exerts potent antitumor effects in animal models of colon cancer and melanoma
-
Schmitt, E.; Maingret, L.; Puig, P.E.; Rerole, A.L.; Ghir-inghelli, F.; Hammann, A.; Solary, E.; Kroemer, G.; Garrido, C. Heat shock protein 70 neutralization exerts potent antitumor effects in animal models of colon cancer and melanoma. Cancer Res., 2006, 66(8), 4191-4197.
-
(2006)
Cancer Res
, vol.66
, Issue.8
, pp. 4191-4197
-
-
Schmitt, E.1
Maingret, L.2
Puig, P.E.3
Rerole, A.L.4
Ghir-Inghelli, F.5
Hammann, A.6
Solary, E.7
Kroemer, G.8
Garrido, C.9
-
13
-
-
84938974589
-
Hsp70 in cancer: Back to the future
-
Sherman, M.Y.; Gabai, V.L. Hsp70 in cancer: back to the future. Oncogene, 2015, 34(32), 4153-4161.
-
(2015)
Oncogene
, vol.34
, Issue.32
, pp. 4153-4161
-
-
Sherman, M.Y.1
Gabai, V.L.2
-
14
-
-
2342651518
-
Molecular chaperones and the stress of oncogenesis
-
Mosser, D.D.; Morimoto, R.I. Molecular chaperones and the stress of oncogenesis. Oncogene, 2004, 23(16), 2907-2918.
-
(2004)
Oncogene
, vol.23
, Issue.16
, pp. 2907-2918
-
-
Mosser, D.D.1
Morimoto, R.I.2
-
15
-
-
0030739208
-
Role of the human heat shock protein hsp70 in protection against stress-induced apoptosis
-
Mosser, D.D.; Caron, A.W.; Bourget, L.; Denis-Larose, C.; Massie, B. Role of the human heat shock protein hsp70 in protection against stress-induced apoptosis. Mol. Cell. Biol., 1997, 17(9), 5317-5327.
-
(1997)
Mol. Cell. Biol.
, vol.17
, Issue.9
, pp. 5317-5327
-
-
Mosser, D.D.1
Caron, A.W.2
Bourget, L.3
Denis-Larose, C.4
Massie, B.5
-
16
-
-
68149132397
-
Heat shock protein 70 silencing enhances apoptosis inducing factor-mediated cell death in hepatocellular carcinoma HepG2 cells
-
Zhu, Q.; Xu, Y.M.; Wang, L.F.; Zhang, Y.; Wang, F.; Zhao, J.; Jia, L.T.; Zhang, W.G.; Yang, A.G. Heat shock protein 70 silencing enhances apoptosis inducing factor-mediated cell death in hepatocellular carcinoma HepG2 cells. Cancer Biol. Ther., 2009, 8(9), 792-798.
-
(2009)
Cancer Biol. Ther.
, vol.8
, Issue.9
, pp. 792-798
-
-
Zhu, Q.1
Xu, Y.M.2
Wang, L.F.3
Zhang, Y.4
Wang, F.5
Zhao, J.6
Jia, L.T.7
Zhang, W.G.8
Yang, A.G.9
-
17
-
-
1242307957
-
Ectopic expression of Hsp70 confers resistance and silencing its expression sensitizes human colon cancer cells to curcumin-induced apoptosis
-
Rashmi, R.; Kumar, S.; Karunagaran, D. Ectopic expression of Hsp70 confers resistance and silencing its expression sensitizes human colon cancer cells to curcumin-induced apoptosis. Carcinogenesis, 2004, 25(2), 179-187.
-
(2004)
Carcinogenesis
, vol.25
, Issue.2
, pp. 179-187
-
-
Rashmi, R.1
Kumar, S.2
Karunagaran, D.3
-
18
-
-
0027227379
-
Differential subcellular distribution of mortalin in mortal and immortal mouse and human fibroblasts
-
Wadhwa, R.; Kaul, S.C.; Mitsui, Y.; Sugimoto, Y. Differential subcellular distribution of mortalin in mortal and immortal mouse and human fibroblasts. Exp. Cell Res., 1993, 207(2), 442-448.
-
(1993)
Exp. Cell Res.
, vol.207
, Issue.2
, pp. 442-448
-
-
Wadhwa, R.1
Kaul, S.C.2
Mitsui, Y.3
Sugimoto, Y.4
-
19
-
-
79955827220
-
Mortalin-p53 interaction in cancer cells is stress dependent and constitutes a selective target for cancer therapy
-
Lu, W.J.; Lee, N.P.; Kaul, S.C.; Lan, F.; Poon, R.T.; Wadhwa, R.; Luk, J.M. Mortalin-p53 interaction in cancer cells is stress dependent and constitutes a selective target for cancer therapy. Cell Death Differ., 2011, 18(6), 1046-1056.
-
(2011)
Cell Death Differ
, vol.18
, Issue.6
, pp. 1046-1056
-
-
Lu, W.J.1
Lee, N.P.2
Kaul, S.C.3
Lan, F.4
Poon, R.T.5
Wadhwa, R.6
Luk, J.M.7
-
20
-
-
84943422058
-
Rezvani, K. A plant alkaloid, veratridine, potentiates cancer chemosensitivity by UBXN2A-dependent inhibition of an oncoprotein, mortalin-2
-
Abdullah, A.; Sane, S.; Branick, K.A.; Freeling, J.L.; Wang, H.; Zhang, D.; Rezvani, K. A plant alkaloid, veratridine, potentiates cancer chemosensitivity by UBXN2A-dependent inhibition of an oncoprotein, mortalin-2. Oncotarget, 2015, 6(27), 23561-23581.
-
(2015)
Oncotarget
, vol.6
, Issue.27
, pp. 23561-23581
-
-
Abdullah, A.1
Sane, S.2
Branick, K.A.3
Freeling, J.L.4
Wang, H.5
Zhang, D.6
-
21
-
-
84886885205
-
A mortalin/HSPA9-mediated switch in tumor-suppressive signaling of Raf/ MEK/extracellular signal-regulated kinase
-
Wu, P.K.; Hong, S.K.; Veeranki, S.; Karkhanis, M.; Starenki, D.; Plaza, J.A.; Park, J.I. A mortalin/HSPA9-mediated switch in tumor-suppressive signaling of Raf/ MEK/extracellular signal-regulated kinase. Mol. Cell. Biol., 2013, 33(20), 4051-4067.
-
(2013)
Mol. Cell. Biol.
, vol.33
, Issue.20
, pp. 4051-4067
-
-
Wu, P.K.1
Hong, S.K.2
Veeranki, S.3
Karkhanis, M.4
Starenki, D.5
Plaza, J.A.6
Park, J.I.7
-
22
-
-
77955639966
-
Tumor suppression by apoptotic and anti-angiogenic effects of mortalin-targeting adeno-onco-lytic virus
-
Yoo, J.Y.; Ryu, J.; Gao, R.; Yaguchi, T.; Kaul, S.C.; Wadhwa, R.; Yun, C.O. Tumor suppression by apoptotic and anti-angiogenic effects of mortalin-targeting adeno-onco-lytic virus. J. Gene Med., 2010, 12(7), 586-595.
-
(2010)
J. Gene Med.
, vol.12
, Issue.7
, pp. 586-595
-
-
Yoo, J.Y.1
Ryu, J.2
Gao, R.3
Yaguchi, T.4
Kaul, S.C.5
Wadhwa, R.6
Yun, C.O.7
-
23
-
-
0032491426
-
Inactivation of tumor suppressor p53 by mot-2, a hsp70 family member
-
Wadhwa, R.; Takano, S.; Robert, M.; Yoshida, A.; Nomura, H.; Reddel, R.R.; Mitsui, Y.; Kaul, S.C. Inactivation of tumor suppressor p53 by mot-2, a hsp70 family member. J. Biol. Chem., 1998, 273(45), 29586-29591.
-
(1998)
J. Biol. Chem.
, vol.273
, Issue.45
, pp. 29586-29591
-
-
Wadhwa, R.1
Takano, S.2
Robert, M.3
Yoshida, A.4
Nomura, H.5
Reddel, R.R.6
Mitsui, Y.7
Kaul, S.C.8
-
24
-
-
84894414901
-
Mortalin and DJ-1 coordinately regulate hematopoietic stem cell function through the control of oxidative stress
-
Tai-Nagara, I.; Matsuoka, S.; Ariga, H.; Suda, T. Mortalin and DJ-1 coordinately regulate hematopoietic stem cell function through the control of oxidative stress. Blood, 2014, 123(1), 41-50.
-
(2014)
Blood
, vol.123
, Issue.1
, pp. 41-50
-
-
Tai-Nagara, I.1
Matsuoka, S.2
Ariga, H.3
Suda, T.4
-
25
-
-
84891904072
-
Overexpression of Mortalin in hepatocellular carcinoma and its relationship with angiogenesis and epithelial to mesenchymal transition
-
Chen, J.; Liu, W.B.; Jia, W.D.; Xu, G.L.; Ma, J.L.; Huang, M.; Deng, Y.R.; Li, J.S. Overexpression of Mortalin in hepatocellular carcinoma and its relationship with angiogenesis and epithelial to mesenchymal transition. Int. J. Oncol., 2014, 44(1), 247-255.
-
(2014)
Int. J. Oncol.
, vol.44
, Issue.1
, pp. 247-255
-
-
Chen, J.1
Liu, W.B.2
Jia, W.D.3
Xu, G.L.4
Ma, J.L.5
Huang, M.6
Deng, Y.R.7
Li, J.S.8
-
26
-
-
11144349225
-
Mortalin is over-expressed by colorectal adenocarcinomas and correlates with poor survival
-
Dundas, S.R.; Lawrie, L.C.; Rooney, P.H.; Murray, G.I. Mortalin is over-expressed by colorectal adenocarcinomas and correlates with poor survival. J. Pathol., 2005, 205(1), 74-81.
-
(2005)
J. Pathol.
, vol.205
, Issue.1
, pp. 74-81
-
-
Dundas, S.R.1
Lawrie, L.C.2
Rooney, P.H.3
Murray, G.I.4
-
27
-
-
85052886350
-
Maehara, Y. Maehara, Prognostic significance of mortalin expresion in gastric adenocarcinoma with wild-type p53
-
abstr e14662
-
Oki, E.; Saeki, K. A. H.; Ohga, T.; Kakeji, Y.; Tsujitani, S.; Kusumoto, T.; Maehara, Y. Maehara, Prognostic significance of mortalin expresion in gastric adenocarcinoma with wild-type p53. J. Clin. Oncol., 2011, 29 abstr e14662
-
(2011)
J. Clin. Oncol.
, pp. 29
-
-
Oki, E.1
Saeki, K.A.H.2
Ohga, T.3
Kakeji, Y.4
Tsujitani, S.5
Kusumoto, T.6
-
28
-
-
84877800312
-
Elevated levels of mitochondrial mortalin and cytosolic HSP70 in blood as risk factors in patients with colorectal cancer
-
Rozenberg, P.; Kocsis, J.; Saar, M.; Prohászka, Z.; Füst, G.; Fishelson, Z. Elevated levels of mitochondrial mortalin and cytosolic HSP70 in blood as risk factors in patients with colorectal cancer. Int. J. Cancer, 2013, 133(2), 514-518.
-
(2013)
Int. J. Cancer
, vol.133
, Issue.2
, pp. 514-518
-
-
Rozenberg, P.1
Kocsis, J.2
Saar, M.3
Prohászka, Z.4
Füst, G.5
Fishelson, Z.6
-
29
-
-
84994652568
-
Targeted therapies in colorectal cancer-an integrative view by PPPM
-
Hagan, S.; Orr, M.C.; Doyle, B. Targeted therapies in colorectal cancer-an integrative view by PPPM. EPMA J., 2013, 4(1), 3.
-
(2013)
EPMA J
, vol.4
, Issue.1
, pp. 3
-
-
Hagan, S.1
Orr, M.C.2
Doyle, B.3
-
30
-
-
78649751640
-
Adjuvant colon cancer chemotherapy: Where we are and where we’ll go
-
Lombardi, L.; Morelli, F.; Cinieri, S.; Santini, D.; Silvestris, N.; Fazio, N.; Orlando, L.; Tonini, G.; Colucci, G.; Maiello, E. Adjuvant colon cancer chemotherapy: where we are and where we’ll go. Cancer Treat. Rev., 2010, 36(Suppl. 3), S34-S41.
-
(2010)
Cancer Treat. Rev.
, vol.36
, pp. S34-S41
-
-
Lombardi, L.1
Morelli, F.2
Cinieri, S.3
Santini, D.4
Silvestris, N.5
Fazio, N.6
Orlando, L.7
Tonini, G.8
Colucci, G.9
Maiello, E.10
-
31
-
-
79961204828
-
Screening for colorectal cancer
-
He, J.; Efron, J.E. Screening for colorectal cancer. Adv. Surg., 2011, 45, 31-44.
-
(2011)
Adv. Surg.
, vol.45
, pp. 31-44
-
-
He, J.1
Efron, J.E.2
-
32
-
-
84922754254
-
A review of the evolution of systemic chemotherapy in the management of colorectal cancer
-
Gustavsson, B.; Carlsson, G.; Machover, D.; Petrelli, N.; Roth, A.; Schmoll, H.J.; Tveit, K.M.; Gibson, F. A review of the evolution of systemic chemotherapy in the management of colorectal cancer. Clin. Colorectal Cancer, 2015, 14(1), 1-10.
-
(2015)
Clin. Colorectal Cancer
, vol.14
, Issue.1
, pp. 1-10
-
-
Gustavsson, B.1
Carlsson, G.2
Machover, D.3
Petrelli, N.4
Roth, A.5
Schmoll, H.J.6
Tveit, K.M.7
Gibson, F.8
-
33
-
-
34249085552
-
Proteasomes: Machines for all reasons
-
Demartino, G.N.; Gillette, T.G. Proteasomes: machines for all reasons. Cell, 2007, 129(4), 659-662.
-
(2007)
Cell
, vol.129
, Issue.4
, pp. 659-662
-
-
Demartino, G.N.1
Gillette, T.G.2
-
34
-
-
33845933730
-
Colorectal cancer
-
Gill, S.; Blackstock, A.W.; Goldberg, R.M. Colorectal cancer. Mayo Clin. Proc., 2007, 82(1), 114-129.
-
(2007)
Mayo Clin. Proc.
, vol.82
, Issue.1
, pp. 114-129
-
-
Gill, S.1
Blackstock, A.W.2
Goldberg, R.M.3
-
35
-
-
84921415334
-
Recent therapeutic advances in the treatment of colorectal cancer
-
Ciombor, K.K.; Wu, C.; Goldberg, R.M. Recent therapeutic advances in the treatment of colorectal cancer. Annu. Rev. Med., 2015, 66, 83-95.
-
(2015)
Annu. Rev. Med.
, vol.66
, pp. 83-95
-
-
Ciombor, K.K.1
Wu, C.2
Goldberg, R.M.3
-
36
-
-
33745464490
-
Fluorinated pyrimidines, a new class of tu- mour-inhibitory compounds
-
Heidelberger, C.; Chaudhuri, N.K.; Danneberg, P.; Mooren, D.; Griesbach, L.; Duschinsky, R.; Schnitzer, R.J.; Pleven, E.; Scheiner, J. Fluorinated pyrimidines, a new class of tu- mour-inhibitory compounds. Nature, 1957, 179(4561), 663-666.
-
(1957)
Nature
, vol.179
, Issue.4561
, pp. 663-666
-
-
Heidelberger, C.1
Chaudhuri, N.K.2
Danneberg, P.3
Mooren, D.4
Griesbach, L.5
Duschinsky, R.6
Schnitzer, R.J.7
Pleven, E.8
Scheiner, J.9
-
37
-
-
0017716458
-
Thymidylate synthetase - a target enzyme in cancer chemotherapy
-
Danenberg, P.V. Thymidylate synthetase - a target enzyme in cancer chemotherapy. Biochim. Biophys. Acta, 1977, 473(2), 73-92.
-
(1977)
Biochim. Biophys. Acta
, vol.473
, Issue.2
, pp. 73-92
-
-
Danenberg, P.V.1
-
38
-
-
0005086073
-
Cytotoxicity of 5-fluoro-2′-deoxyuridine: Requirement for reduced folate cofactors and antagonism by methotrexate
-
Ullman, B.; Lee, M.; Martin, D.W., Jr; Santi, D.V. Cytotoxicity of 5-fluoro-2′-deoxyuridine: requirement for reduced folate cofactors and antagonism by methotrexate. Proc. Natl. Acad. Sci. USA, 1978, 75(2), 980-983.
-
(1978)
Proc. Natl. Acad. Sci. USA
, vol.75
, Issue.2
, pp. 980-983
-
-
Ullman, B.1
Lee, M.2
Martin, D.W.3
Santi, D.V.4
-
39
-
-
0025363288
-
Enhancement of the antitumor effects of 5-fluorouracil by folinic acid
-
Mini, E.; Trave, F.; Rustum, Y.M.; Bertino, J.R. Enhancement of the antitumor effects of 5-fluorouracil by folinic acid. Pharmacol. Ther., 1990, 47(1), 1-19.
-
(1990)
Pharmacol. Ther.
, vol.47
, Issue.1
, pp. 1-19
-
-
Mini, E.1
Trave, F.2
Rustum, Y.M.3
Bertino, J.R.4
-
40
-
-
0024347268
-
Biochemical modulation of fluorouracil: Evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma
-
Poon, M.A.; O’Connell, M.J.; Moertel, C.G.; Wieand, H.S.; Cullinan, S.A.; Everson, L.K.; Krook, J.E.; Mailliard, J.A.; Laurie, J.A.; Tschetter, L.K. Biochemical modulation of fluorouracil: evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma. J. Clin. Oncol., 1989, 7(10), 1407-1418.
-
(1989)
J. Clin. Oncol.
, vol.7
, Issue.10
, pp. 1407-1418
-
-
Poon, M.A.1
O’Connell, M.J.2
Moertel, C.G.3
Wieand, H.S.4
Cullinan, S.A.5
Everson, L.K.6
Krook, J.E.7
Mailliard, J.A.8
Laurie, J.A.9
Tschetter, L.K.10
-
41
-
-
0026006962
-
Biochemical modulation of fluorouracil with leucovorin: Confirmatory evidence of improved therapeutic efficacy in advanced colorectal cancer
-
Poon, M.A.; O’Connell, M.J.; Wieand, H.S.; Krook, J.E.; Gerstner, J.B.; Tschetter, L.K.; Levitt, R.; Kardinal, C.G.; Mailliard, J.A. Biochemical modulation of fluorouracil with leucovorin: confirmatory evidence of improved therapeutic efficacy in advanced colorectal cancer. J. Clin. Oncol., 1991, 9(11), 1967-1972.
-
(1991)
J. Clin. Oncol.
, vol.9
, Issue.11
, pp. 1967-1972
-
-
Poon, M.A.1
O’Connell, M.J.2
Wieand, H.S.3
Krook, J.E.4
Gerstner, J.B.5
Tschetter, L.K.6
Levitt, R.7
Kardinal, C.G.8
Mailliard, J.A.9
-
42
-
-
4644252335
-
Meta-Analysis Group in Cancer. Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: An updated meta-analysis
-
Thirion, P.; Michiels, S.; Pignon, J.P.; Buyse, M.; Braud, A.C.; Carlson, R.W.; O’Connell, M.; Sargent, P.; Piedbois, P. Meta-Analysis Group in Cancer. Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: an updated meta-analysis. J. Clin. Oncol., 2004, 22(18), 3766-3775.
-
(2004)
J. Clin. Oncol.
, vol.22
, Issue.18
, pp. 3766-3775
-
-
Thirion, P.1
Michiels, S.2
Pignon, J.P.3
Buyse, M.4
Braud, A.C.5
Carlson, R.W.6
O’Connell, M.7
Sargent, P.8
Piedbois, P.9
-
43
-
-
0023552964
-
Antitumor activity of 7-ethyl-10-[4-(1-piperi-dino)-1-piperidino]carbonyloxy-camptothec in, a novel wa-ter-soluble derivative of camptothecin, against murine tumors
-
Kunimoto, T.; Nitta, K.; Tanaka, T.; Uehara, N.; Baba, H.; Takeuchi, M.; Yokokura, T.; Sawada, S.; Miyasaka, T.; Mutai, M. Antitumor activity of 7-ethyl-10-[4-(1-piperi-dino)-1-piperidino]carbonyloxy-camptothec in, a novel wa-ter-soluble derivative of camptothecin, against murine tumors. Cancer Res., 1987, 47(22), 5944-5947.
-
(1987)
Cancer Res.
, vol.47
, Issue.22
, pp. 5944-5947
-
-
Kunimoto, T.1
Nitta, K.2
Tanaka, T.3
Uehara, N.4
Baba, H.5
Takeuchi, M.6
Yokokura, T.7
Sawada, S.8
Miyasaka, T.9
Mutai, M.10
-
44
-
-
0018943536
-
Antitumor activity of platinum(II) complexes of 1,2-diamino-cyclohexane isomers
-
Kidani, Y.; Noji, M.; Tashiro, T. Antitumor activity of platinum(II) complexes of 1,2-diamino-cyclohexane isomers. Gan, 1980, 71(5), 637-643.
-
(1980)
Gan
, vol.71
, Issue.5
, pp. 637-643
-
-
Kidani, Y.1
Noji, M.2
Tashiro, T.3
-
45
-
-
0034727063
-
Irinotecan Study Group. Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer
-
Saltz, L.B.; Cox, J.V.; Blanke, C.; Rosen, L.S.; Fehrenbacher, L.; Moore, M.J.; Maroun, J.A.; Ackland, S.P.; Locker, P.K.; Pirotta, N.; Elfring, G.L.; Miller, L.L. Irinotecan Study Group. Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. N. Engl. J. Med., 2000, 343(13), 905-914.
-
(2000)
N. Engl. J. Med.
, vol.343
, Issue.13
, pp. 905-914
-
-
Saltz, L.B.1
Cox, J.V.2
Blanke, C.3
Rosen, L.S.4
Fehrenbacher, L.5
Moore, M.J.6
Maroun, J.A.7
Ackland, S.P.8
Locker, P.K.9
Pirotta, N.10
Elfring, G.L.11
Miller, L.L.12
-
46
-
-
2942638081
-
XELOX (Capecitabine plus oxaliplatin): Active first-line therapy for patients with metastatic colorectal cancer
-
Cassidy, J.; Tabernero, J.; Twelves, C.; Brunet, R.; Butts, C.; Conroy, T.; Debraud, F.; Figer, A.; Grossmann, J.; Sawada, N.; Schöffski, P.; Sobrero, A.; Van Cutsem, E.; Díaz-Rubio, E. XELOX (capecitabine plus oxaliplatin): active first-line therapy for patients with metastatic colorectal cancer. J. Clin. Oncol., 2004, 22(11), 2084-2091.
-
(2004)
J. Clin. Oncol.
, vol.22
, Issue.11
, pp. 2084-2091
-
-
Cassidy, J.1
Tabernero, J.2
Twelves, C.3
Brunet, R.4
Butts, C.5
Conroy, T.6
Debraud, F.7
Figer, A.8
Grossmann, J.9
Sawada, N.10
Schöffski, P.11
Sobrero, A.12
van Cutsem, E.13
Díaz-Rubio, E.14
-
47
-
-
84937143954
-
Metastatic colorectal cancer: Current state and future directions
-
Fakih, M.G. Metastatic colorectal cancer: current state and future directions. J. Clin. Oncol., 2015, 33(16), 1809-1824.
-
(2015)
J. Clin. Oncol.
, vol.33
, Issue.16
, pp. 1809-1824
-
-
Fakih, M.G.1
-
48
-
-
84868618639
-
Vascular Endothelial Growth Factor (VEGF) and its receptor (VEGFR) signaling in angiogenesis: A crucial target for anti- and pro-angiogenic therapies
-
Shibuya, M. Vascular Endothelial Growth Factor (VEGF) and its receptor (VEGFR) signaling in angiogenesis: a crucial target for anti- and pro-angiogenic therapies. Genes Cancer, 2011, 2(12), 1097-1105.
-
(2011)
Genes Cancer
, vol.2
, Issue.12
, pp. 1097-1105
-
-
Shibuya, M.1
-
49
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
Hurwitz, H.; Fehrenbacher, L.; Novotny, W.; Cartwright, T.; Hainsworth, J.; Heim, W.; Berlin, J.; Baron, A.; Griffing, S.; Holmgren, E.; Ferrara, N.; Fyfe, G.; Rogers, B.; Ross, R.; Kabbinavar, F. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N. Engl. J. Med., 2004, 350(23), 2335-2342.
-
(2004)
N. Engl. J. Med.
, vol.350
, Issue.23
, pp. 2335-2342
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
Cartwright, T.4
Hainsworth, J.5
Heim, W.6
Berlin, J.7
Baron, A.8
Griffing, S.9
Holmgren, E.10
Ferrara, N.11
Fyfe, G.12
Rogers, B.13
Ross, R.14
Kabbinavar, F.15
-
50
-
-
80054779014
-
Efficacy and safety of bevacizumab plus chemotherapy in Chinese patients with metastatic colorectal cancer: A randomized phase III ART-IST trial
-
Guan, Z.Z.; Xu, J.M.; Luo, R.C.; Feng, F.Y.; Wang, L.W.; Shen, L.; Yu, S.Y.; Ba, Y.; Liang, J.; Wang, D.; Qin, S.K.; Wang, J.J.; He, J.; Qi, C.; Xu, R.H. Efficacy and safety of bevacizumab plus chemotherapy in Chinese patients with metastatic colorectal cancer: a randomized phase III ART-IST trial. Chin J Cancer, 2011, 30(10), 682-689.
-
(2011)
Chin J Cancer
, vol.30
, Issue.10
, pp. 682-689
-
-
Guan, Z.Z.1
Xu, J.M.2
Luo, R.C.3
Feng, F.Y.4
Wang, L.W.5
Shen, L.6
Yu, S.Y.7
Ba, Y.8
Liang, J.9
Wang, D.10
Qin, S.K.11
Wang, J.J.12
He, J.13
Qi, C.14
Xu, R.H.15
-
51
-
-
84857660379
-
The continuation of bevacizumab following disease progression in patients with metastatic colorectal cancer offers a survival benefit
-
Samelis, G.F.; Ekmektzoglou, K.A.; Tsiakou, A.; Konsta-doulakis, M. The continuation of bevacizumab following disease progression in patients with metastatic colorectal cancer offers a survival benefit. Hepatogastroenterology, 2011, 58(112), 1968-1971.
-
(2011)
Hepatogastroenterology
, vol.58
, Issue.112
, pp. 1968-1971
-
-
Samelis, G.F.1
Ekmektzoglou, K.A.2
Tsiakou, A.3
Konsta-Doulakis, M.4
-
52
-
-
84908540607
-
Targeted therapies in metastatic colorectal cancer: A systematic review and assessment of currently available data
-
Kirstein, M.M.; Lange, A.; Prenzler, A.; Manns, M.P.; Ku-bicka, S.; Vogel, A. Targeted therapies in metastatic colorectal cancer: a systematic review and assessment of currently available data. Oncologist, 2014, 19(11), 1156-1168.
-
(2014)
Oncologist
, vol.19
, Issue.11
, pp. 1156-1168
-
-
Kirstein, M.M.1
Lange, A.2
Prenzler, A.3
Manns, M.P.4
Ku-Bicka, S.5
Vogel, A.6
-
53
-
-
79954499886
-
Regorafenib (BAY 73-4506): A new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity
-
Wilhelm, S.M.; Dumas, J.; Adnane, L.; Lynch, M.; Carter, C.A.; Schütz, G.; Thierauch, K.H.; Zopf, D. Regorafenib (BAY 73-4506): a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity. Int. J. Cancer, 2011, 129(1), 245-255.
-
(2011)
Int. J. Cancer
, vol.129
, Issue.1
, pp. 245-255
-
-
Wilhelm, S.M.1
Dumas, J.2
Adnane, L.3
Lynch, M.4
Carter, C.A.5
Schütz, G.6
Thierauch, K.H.7
Zopf, D.8
-
54
-
-
0019305094
-
Genetic analysis of epidermal growth factor action: Assignment of human epidermal growth factor receptor gene to chromosome 7
-
Davies, R.L.; Grosse, V.A.; Kucherlapati, R.; Bothwell, M. Genetic analysis of epidermal growth factor action: assignment of human epidermal growth factor receptor gene to chromosome 7. Proc. Natl. Acad. Sci. USA, 1980, 77(7), 4188-4192.
-
(1980)
Proc. Natl. Acad. Sci. USA
, vol.77
, Issue.7
, pp. 4188-4192
-
-
Davies, R.L.1
Grosse, V.A.2
Kucherlapati, R.3
Bothwell, M.4
-
55
-
-
63849088630
-
Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
-
Van Cutsem, E.; Köhne, C.H.; Hitre, E.; Zaluski, J.; Chang Chien, C.R.; Makhson, A.; D’Haens, G.; Pintér, T.; Lim, R.; Bodoky, G.; Roh, J.K.; Folprecht, G.; Ruff, P.; Stroh, C.; Tejpar, S.; Schlichting, M.; Nippgen, J.; Rougier, P. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N. Engl. J. Med., 2009, 360(14), 1408-1417.
-
(2009)
N. Engl. J. Med.
, vol.360
, Issue.14
, pp. 1408-1417
-
-
van Cutsem, E.1
Köhne, C.H.2
Hitre, E.3
Zaluski, J.4
Chang Chien, C.R.5
Makhson, A.6
D’Haens, G.7
Pintér, T.8
Lim, R.9
Bodoky, G.10
Roh, J.K.11
Folprecht, G.12
Ruff, P.13
Stroh, C.14
Tejpar, S.15
Schlichting, M.16
Nippgen, J.17
Rougier, P.18
-
56
-
-
78149250536
-
Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: The PRIME study
-
Douillard, J.Y.; Siena, S.; Cassidy, J.; Tabernero, J.; Burkes, R.; Barugel, M.; Humblet, Y.; Bodoky, G.; Cunningham, D.; Jassem, J.; Rivera, F.; Kocákova, I.; Ruff, P.; Błasińska-Morawiec, M.; Šmakal, M.; Canon, J.L.; Rother, M.; Oliner, K.S.; Wolf, M.; Gansert, J. Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: the PRIME study. J. Clin. Oncol., 2010, 28(31), 4697-4705.
-
(2010)
J. Clin. Oncol.
, vol.28
, Issue.31
, pp. 4697-4705
-
-
Douillard, J.Y.1
Siena, S.2
Cassidy, J.3
Tabernero, J.4
Burkes, R.5
Barugel, M.6
Humblet, Y.7
Bodoky, G.8
Cunningham, D.9
Jassem, J.10
Rivera, F.11
Kocákova, I.12
Ruff, P.13
Błasińska-Morawiec, M.14
Šmakal, M.15
Canon, J.L.16
Rother, M.17
Oliner, K.S.18
Wolf, M.19
Gansert, J.20
more..
-
57
-
-
84899981129
-
Panitumumab versus cetuximab in patients with chemotherapy-refractory wild-type KRAS exon 2 metastatic colorectal cancer (AS-PECCT): A randomised, multicentre, open-label, non-inferiority phase 3 study
-
Price, T.J.; Peeters, M.; Kim, T.W.; Li, J.; Cascinu, S.; Ruff, P.; Suresh, A.S.; Thomas, A.; Tjulandin, S.; Zhang, K.; Murugappan, S.; Sidhu, R. Panitumumab versus cetuximab in patients with chemotherapy-refractory wild-type KRAS exon 2 metastatic colorectal cancer (AS-PECCT): a randomised, multicentre, open-label, non-inferiority phase 3 study. Lancet Oncol., 2014, 15(6), 569-579.
-
(2014)
Lancet Oncol
, vol.15
, Issue.6
, pp. 569-579
-
-
Price, T.J.1
Peeters, M.2
Kim, T.W.3
Li, J.4
Cascinu, S.5
Ruff, P.6
Suresh, A.S.7
Thomas, A.8
Tjulandin, S.9
Zhang, K.10
Murugappan, S.11
Sidhu, R.12
-
58
-
-
58149242890
-
A phase II study of gefitinib, 5-fluorouracil, leucovorin, and oxaliplatin in previously untreated patients with metastatic colorectal cancer
-
Fisher, G.A.; Kuo, T.; Ramsey, M.; Schwartz, E.; Rouse, R.V.; Cho, C.D.; Halsey, J.; Sikic, B.I. A phase II study of gefitinib, 5-fluorouracil, leucovorin, and oxaliplatin in previously untreated patients with metastatic colorectal cancer. Clin. Cancer Res., 2008, 14(21), 7074-7079.
-
(2008)
Clin. Cancer Res.
, vol.14
, Issue.21
, pp. 7074-7079
-
-
Fisher, G.A.1
Kuo, T.2
Ramsey, M.3
Schwartz, E.4
Rouse, R.V.5
Cho, C.D.6
Halsey, J.7
Sikic, B.I.8
-
59
-
-
33646361363
-
Phase II study of capecitabine, oxaliplatin, and erlotinib in previously treated patients with metastastic colorectal cancer
-
Meyerhardt, J.A.; Zhu, A.X.; Enzinger, P.C.; Ryan, D.P.; Clark, J.W.; Kulke, M.H.; Earle, C.C.; Vincitore, M.; Mich-elini, A.; Sheehan, S.; Fuchs, C.S. Phase II study of capecitabine, oxaliplatin, and erlotinib in previously treated patients with metastastic colorectal cancer. J. Clin. Oncol., 2006, 24(12), 1892-1897.
-
(2006)
J. Clin. Oncol.
, vol.24
, Issue.12
, pp. 1892-1897
-
-
Meyerhardt, J.A.1
Zhu, A.X.2
Enzinger, P.C.3
Ryan, D.P.4
Clark, J.W.5
Kulke, M.H.6
Earle, C.C.7
Vincitore, M.8
Mich-Elini, A.9
Sheehan, S.10
Fuchs, C.S.11
-
60
-
-
33644822287
-
Randomized phase II trial of the clinical and biological effects of two dose levels of gefitinib in patients with recurrent colorectal adenocarcinoma
-
Rothenberg, M.L.; LaFleur, B.; Levy, D.E.; Washington, M.K.; Morgan-Meadows, S.L.; Ramanathan, R.K.; Berlin, J.D.; Benson, A.B., III; Coffey, R.J. Randomized phase II trial of the clinical and biological effects of two dose levels of gefitinib in patients with recurrent colorectal adenocarcinoma. J. Clin. Oncol., 2005, 23(36), 9265-9274.
-
(2005)
J. Clin. Oncol.
, vol.23
, Issue.36
, pp. 9265-9274
-
-
Rothenberg, M.L.1
Lafleur, B.2
Levy, D.E.3
Washington, M.K.4
Morgan-Meadows, S.L.5
Ramanathan, R.K.6
Berlin, J.D.7
Benson, A.B.8
Coffey, R.J.9
-
61
-
-
33646143020
-
Phase II study of erlotinib (OSI- 774) in patients with metastatic colorectal cancer
-
Townsley, C.A.; Major, P.; Siu, L.L.; Dancey, J.; Chen, E.; Pond, G.R.; Nicklee, T.; Ho, J.; Hedley, D.; Tsao, M.; Moore, M.J.; Oza, A.M. Phase II study of erlotinib (OSI- 774) in patients with metastatic colorectal cancer. Br. J. Cancer, 2006, 94(8), 1136-1143.
-
(2006)
Br. J. Cancer
, vol.94
, Issue.8
, pp. 1136-1143
-
-
Townsley, C.A.1
Major, P.2
Siu, L.L.3
Dancey, J.4
Chen, E.5
Pond, G.R.6
Nicklee, T.7
Ho, J.8
Hedley, D.9
Tsao, M.10
Moore, M.J.11
Oza, A.M.12
-
62
-
-
33646228635
-
KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer
-
Lièvre, A.; Bachet, J.B.; Le Corre, D.; Boige, V.; Landi, B.; Emile, J.F.; Côté, J.F.; Tomasic, G.; Penna, C.; Ducreux, M.; Rougier, P.; Penault-Llorca, F.; Laurent-Puig, P. KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. Cancer Res., 2006, 66(8), 3992-3995.
-
(2006)
Cancer Res
, vol.66
, Issue.8
, pp. 3992-3995
-
-
Lièvre, A.1
Bachet, J.B.2
Le Corre, D.3
Boige, V.4
Landi, B.5
Emile, J.F.6
Côté, J.F.7
Tomasic, G.8
Penna, C.9
Ducreux, M.10
Rougier, P.11
Penault-Llorca, F.12
Laurent-Puig, P.13
-
63
-
-
84883680951
-
Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer
-
Douillard, J.Y.; Oliner, K.S.; Siena, S.; Tabernero, J.; Burkes, R.; Barugel, M.; Humblet, Y.; Bodoky, G.; Cunningham, D.; Jassem, J.; Rivera, F.; Kocákova, I.; Ruff, P.; Błasińska-Morawiec, M.; Šmakal, M.; Canon, J.L.; Rother, M.; Williams, R.; Rong, A.; Wiezorek, J.; Sidhu, R.; Patterson, S.D. Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer. N. Engl. J. Med., 2013, 369(11), 1023-1034.
-
(2013)
N. Engl. J. Med.
, vol.369
, Issue.11
, pp. 1023-1034
-
-
Douillard, J.Y.1
Oliner, K.S.2
Siena, S.3
Tabernero, J.4
Burkes, R.5
Barugel, M.6
Humblet, Y.7
Bodoky, G.8
Cunningham, D.9
Jassem, J.10
Rivera, F.11
Kocákova, I.12
Ruff, P.13
Błasińska-Morawiec, M.14
Šmakal, M.15
Canon, J.L.16
Rother, M.17
Williams, R.18
Rong, A.19
Wiezorek, J.20
Sidhu, R.21
Patterson, S.D.22
more..
-
65
-
-
77955277111
-
Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: A retrospective consortium analysis
-
De Roock, W.; Claes, B.; Bernasconi, D.; De Schutter, J.; Biesmans, B.; Fountzilas, G.; Kalogeras, K.T.; Kotoula, V.; Papamichael, D.; Laurent-Puig, P.; Penault-Llorca, F.; Rougier, P.; Vincenzi, B.; Santini, D.; Tonini, G.; Cap-puzzo, F.; Frattini, M.; Molinari, F.; Saletti, P.; De Dosso, S.; Martini, M.; Bardelli, A.; Siena, S.; Sartore-Bianchi, A.; Tabernero, J.; Macarulla, T.; Di Fiore, F.; Gangloff, A.O.; Ciardiello, F.; Pfeiffer, P.; Qvortrup, C.; Hansen, T.P.; Van Cutsem, E.; Piessevaux, H.; Lambrechts, D.; Delorenzi, M.; Tejpar, S. Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. Lancet Oncol., 2010, 11(8), 753-762.
-
(2010)
Lancet Oncol
, vol.11
, Issue.8
, pp. 753-762
-
-
de Roock, W.1
Claes, B.2
Bernasconi, D.3
de Schutter, J.4
Biesmans, B.5
Fountzilas, G.6
Kalogeras, K.T.7
Kotoula, V.8
Papamichael, D.9
Laurent-Puig, P.10
Penault-Llorca, F.11
Rougier, P.12
Vincenzi, B.13
Santini, D.14
Tonini, G.15
Cap-Puzzo, F.16
Frattini, M.17
Molinari, F.18
Saletti, P.19
de Dosso, S.20
Martini, M.21
Bardelli, A.22
Siena, S.23
Sartore-Bianchi, A.24
Tabernero, J.25
Macarulla, T.26
Di Fiore, F.27
Gangloff, A.O.28
Ciardiello, F.29
Pfeiffer, P.30
Qvortrup, C.31
Hansen, T.P.32
van Cutsem, E.33
Piessevaux, H.34
Lambrechts, D.35
Delorenzi, M.36
Tejpar, S.37
more..
-
66
-
-
57449095367
-
Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer
-
Di Nicolantonio, F.; Martini, M.; Molinari, F.; Sartore-Bianchi, A.; Arena, S.; Saletti, P.; De Dosso, S.; Mazzuc-chelli, L.; Frattini, M.; Siena, S.; Bardelli, A. Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer. J. Clin. Oncol., 2008, 26(35), 5705-5712.
-
(2008)
J. Clin. Oncol.
, vol.26
, Issue.35
, pp. 5705-5712
-
-
Di Nicolantonio, F.1
Martini, M.2
Molinari, F.3
Sartore-Bianchi, A.4
Arena, S.5
Saletti, P.6
de Dosso, S.7
Mazzuc-Chelli, L.8
Frattini, M.9
Siena, S.10
Bardelli, A.11
-
67
-
-
73349094741
-
Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer
-
Laurent-Puig, P.; Cayre, A.; Manceau, G.; Buc, E.; Bachet, J.B.; Lecomte, T.; Rougier, P.; Lievre, A.; Landi, B.; Boige, V.; Ducreux, M.; Ychou, M.; Bibeau, F.; Bouché, O.; Reid, J.; Stone, S.; Penault-Llorca, F. Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer. J. Clin. Oncol., 2009, 27(35), 5924-5930.
-
(2009)
J. Clin. Oncol.
, vol.27
, Issue.35
, pp. 5924-5930
-
-
Laurent-Puig, P.1
Cayre, A.2
Manceau, G.3
Buc, E.4
Bachet, J.B.5
Lecomte, T.6
Rougier, P.7
Lievre, A.8
Landi, B.9
Boige, V.10
Ducreux, M.11
Ychou, M.12
Bibeau, F.13
Bouché, O.14
Reid, J.15
Stone, S.16
Penault-Llorca, F.17
-
68
-
-
68149165771
-
Prognostic and predictive value of common mutations for treatment response and survival in patients with metastatic colorectal cancer
-
Souglakos, J.; Philips, J.; Wang, R.; Marwah, S.; Silver, M.; Tzardi, M.; Silver, J.; Ogino, S.; Hooshmand, S.; Kwak, E.; Freed, E.; Meyerhardt, J.A.; Saridaki, Z.; Georgoulias, V.; Finkelstein, D.; Fuchs, C.S.; Kulke, M.H.; Shivdasani, R.A. Prognostic and predictive value of common mutations for treatment response and survival in patients with metastatic colorectal cancer. Br. J. Cancer, 2009, 101(3), 465-472.
-
(2009)
Br. J. Cancer
, vol.101
, Issue.3
, pp. 465-472
-
-
Souglakos, J.1
Philips, J.2
Wang, R.3
Marwah, S.4
Silver, M.5
Tzardi, M.6
Silver, J.7
Ogino, S.8
Hooshmand, S.9
Kwak, E.10
Freed, E.11
Meyerhardt, J.A.12
Saridaki, Z.13
Georgoulias, V.14
Finkelstein, D.15
Fuchs, C.S.16
Kulke, M.H.17
Shivdasani, R.A.18
-
69
-
-
84868204016
-
Prognostic value of cetuximab-related skin toxicity in metastatic colorectal cancer patients and its correlation with parameters of the epidermal growth factor receptor signal transduction pathway: Results from a randomized trial of the GERMAN AIO CRC Study Group
-
Stintzing, S.; Kapaun, C.; Laubender, R.P.; Jung, A.; Neu-mann, J.; Modest, D.P.; Giessen, C.; Moosmann, N.; Wol-lenberg, A.; Kirchner, T.; Heinemann, V. Prognostic value of cetuximab-related skin toxicity in metastatic colorectal cancer patients and its correlation with parameters of the epidermal growth factor receptor signal transduction pathway: results from a randomized trial of the GERMAN AIO CRC Study Group. Int. J. Cancer, 2013, 132(1), 236-245.
-
(2013)
Int. J. Cancer
, vol.132
, Issue.1
, pp. 236-245
-
-
Stintzing, S.1
Kapaun, C.2
Laubender, R.P.3
Jung, A.4
Neu-Mann, J.5
Modest, D.P.6
Giessen, C.7
Moosmann, N.8
Wol-Lenberg, A.9
Kirchner, T.10
Heinemann, V.11
-
70
-
-
84872514622
-
Durable cancer regression off-treatment and effective reinduction therapy with an anti-PD-1 antibody
-
Lipson, E.J.; Sharfman, W.H.; Drake, C.G.; Wollner, I.; Taube, J.M.; Anders, R.A.; Xu, H.; Yao, S.; Pons, A.; Chen, L.; Pardoll, D.M.; Brahmer, J.R.; Topalian, S.L. Durable cancer regression off-treatment and effective reinduction therapy with an anti-PD-1 antibody. Clin. Cancer Res., 2013, 19(2), 462-468.
-
(2013)
Clin. Cancer Res.
, vol.19
, Issue.2
, pp. 462-468
-
-
Lipson, E.J.1
Sharfman, W.H.2
Drake, C.G.3
Wollner, I.4
Taube, J.M.5
Anders, R.A.6
Xu, H.7
Yao, S.8
Pons, A.9
Chen, L.10
Pardoll, D.M.11
Brahmer, J.R.12
Topalian, S.L.13
-
71
-
-
84930730522
-
Current state of anti-PD-L1 and anti-PD-1 agents in cancer therapy
-
Swaika, A.; Hammond, W.A.; Joseph, R.W. Current state of anti-PD-L1 and anti-PD-1 agents in cancer therapy. Mol. Immunol., 2015, 67(2 Pt A), 4-17.
-
(2015)
Mol. Immunol.
, vol.67
, Issue.2
, pp. 4-17
-
-
Swaika, A.1
Hammond, W.A.2
Joseph, R.W.3
-
72
-
-
84922675130
-
A dose-escalation phase I study of a first-in-class cancer stemness inhibitor in patients with advanced malignancies
-
Langleben, A.; Supko, J. G.; Hotte, S. J.; Batist, G.; Hirte, H. W.; Rogoff, H.; Li, Y.; Li, W.; Kerstein, D.; Leggett, D.; Hitron, M. J.; Li, C. A dose-escalation phase I study of a first-in-class cancer stemness inhibitor in patients with advanced malignancies. J. Clin. Oncol., 2013, 31 abstr 2542
-
(2013)
J. Clin. Oncol.
, pp. 31
-
-
Langleben, A.1
Supko, J.G.2
Hotte, S.J.3
Batist, G.4
Hirte, H.W.5
Rogoff, H.6
Li, Y.7
Li, W.8
Kerstein, D.9
Leggett, D.10
Hitron, M.J.11
Li, C.12
-
73
-
-
84861863158
-
EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition with vemurafenib
-
Corcoran, R.B.; Ebi, H.; Turke, A.B.; Coffee, E.M.; Ni-shino, M.; Cogdill, A.P.; Brown, R.D.; Della Pelle, P.; Dias-Santagata, D.; Hung, K.E.; Flaherty, K.T.; Piris, A.; Wargo, J.A.; Settleman, J.; Mino-Kenudson, M.; Engelman, J.A. EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition with vemurafenib. Cancer Discov., 2012, 2(3), 227-235.
-
(2012)
Cancer Discov
, vol.2
, Issue.3
, pp. 227-235
-
-
Corcoran, R.B.1
Ebi, H.2
Turke, A.B.3
Coffee, E.M.4
Ni-Shino, M.5
Cogdill, A.P.6
Brown, R.D.7
della Pelle, P.8
Dias-Santagata, D.9
Hung, K.E.10
Flaherty, K.T.11
Piris, A.12
Wargo, J.A.13
Settleman, J.14
Mino-Kenudson, M.15
Engelman, J.A.16
-
74
-
-
84863230465
-
Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR
-
Prahallad, A.; Sun, C.; Huang, S.; Di Nicolantonio, F.; Salazar, R.; Zecchin, D.; Beijersbergen, R.L.; Bardelli, A.; Bernards, R. Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. Nature, 2012, 483(7387), 100-103.
-
(2012)
Nature
, vol.483
, Issue.7387
, pp. 100-103
-
-
Prahallad, A.1
Sun, C.2
Huang, S.3
Di Nicolantonio, F.4
Salazar, R.5
Zecchin, D.6
Beijersbergen, R.L.7
Bardelli, A.8
Bernards, R.9
-
75
-
-
84925134597
-
Phase 1B study of vemurafenib in combination with irinotecan and cetuximab in patients with BRAF-mutated advanced cancers and metastatic colorectal cancer
-
abstr 3516
-
Hong, D.S.; Morris, V.K.; Fu, S.; Overman, M.J.; Piha-Paul, S.A.; Kee, B.K. Phase 1B study of vemurafenib in combination with irinotecan and cetuximab in patients with BRAF-mutated advanced cancers and metastatic colorectal cancer. J. Clin. Oncol., 2014, 32(suppl 5s) abstr 3516
-
(2014)
J. Clin. Oncol.
, vol.32
-
-
Hong, D.S.1
Morris, V.K.2
Fu, S.3
Overman, M.J.4
Piha-Paul, S.A.5
Kee, B.K.6
-
76
-
-
84922636156
-
Phase 1-2 trial of the BRAF inhibitor dabraf-enib (D) plus MEK inhibitor trametinib (T) in BRAF V600 mutant colorectal cancer (CRC): Updated efficacy and biomarker analysis
-
abstr 3517
-
Corcoran, R. B.; Atreya, C. E.; Falchook, G. S.; Infante, J. R.; Hamid, O.; Messersmith, W. A.; Daud, A.; Kwak, E. L.; Ryan, D.; Kurzrock, R.; Sun, P.; Cunningham, E. A.; Or-ford, K. W.; Motwani, M.; Bai, Y.; Patel, K.; Venook, A. P.; Kopetz, S. Phase 1-2 trial of the BRAF inhibitor dabraf-enib (D) plus MEK inhibitor trametinib (T) in BRAF V600 mutant colorectal cancer (CRC): Updated efficacy and biomarker analysis. J. Clin. Oncol., 2014, 32(suppl 5s) abstr 3517
-
(2014)
J. Clin. Oncol.
, vol.32
-
-
Corcoran, R.B.1
Atreya, C.E.2
Falchook, G.S.3
Infante, J.R.4
Hamid, O.5
Messersmith, W.A.6
Daud, A.7
Kwak, E.L.8
Ryan, D.9
Kurzrock, R.10
Sun, P.11
Cunningham, E.A.12
Or-Ford, K.W.13
Motwani, M.14
Bai, Y.15
Patel, K.16
Venook, A.P.17
Kopetz, S.18
-
77
-
-
84896078397
-
Blockade of EGFR and MEK intercepts heterogeneous mechanisms of acquired resistance to anti-EGFR therapies in colorectal cancer
-
Misale, S.; Arena, S.; Lamba, S.; Siravegna, G.; Lallo, A.; Hobor, S.; Russo, M.; Buscarino, M.; Lazzari, L.; Sartore-Bianchi, A.; Bencardino, K.; Amatu, A.; Lauricella, C.; Valtorta, E.; Siena, S.; Di Nicolantonio, F.; Bardelli, A. Blockade of EGFR and MEK intercepts heterogeneous mechanisms of acquired resistance to anti-EGFR therapies in colorectal cancer. Sci. Transl. Med., 2014, 6(224), 224ra26.
-
(2014)
Sci. Transl. Med.
, vol.6
, Issue.224
-
-
Misale, S.1
Arena, S.2
Lamba, S.3
Siravegna, G.4
Lallo, A.5
Hobor, S.6
Russo, M.7
Buscarino, M.8
Lazzari, L.9
Sartore-Bianchi, A.10
Bencardino, K.11
Amatu, A.12
Lauricella, C.13
Valtorta, E.14
Siena, S.15
Di Nicolantonio, F.16
Bardelli, A.17
-
78
-
-
34250561475
-
A new puffing pattern induced by temperature shock and DNP in drosophila
-
Ritossa, F. A new puffing pattern induced by temperature shock and DNP in drosophila. Experientia, 1962, 18(12), 571-573.
-
(1962)
Experientia
, vol.18
, Issue.12
, pp. 571-573
-
-
Ritossa, F.1
-
79
-
-
0030154255
-
Discovery of the heat shock response
-
Ritossa, F. Discovery of the heat shock response. Cell Stress Chaperones, 1996, 1(2), 97-98.
-
(1996)
Cell Stress Chaperones
, vol.1
, Issue.2
, pp. 97-98
-
-
Ritossa, F.1
-
80
-
-
0031297298
-
The heat-shock response: Regulation and function of heat-shock proteins and molecular chaperones
-
Morimoto, R.I.; Kline, M.P.; Bimston, D.N.; Cotto, J.J. The heat-shock response: regulation and function of heat-shock proteins and molecular chaperones. Essays Biochem., 1997, 32, 17-29.
-
(1997)
Essays Biochem
, vol.32
, pp. 17-29
-
-
Morimoto, R.I.1
Kline, M.P.2
Bimston, D.N.3
Cotto, J.J.4
-
81
-
-
0034605446
-
Role of the heat shock response and molecular chaperones in oncogenesis and cell death
-
Jolly, C.; Morimoto, R.I. Role of the heat shock response and molecular chaperones in oncogenesis and cell death. J. Natl. Cancer Inst., 2000, 92(19), 1564-1572.
-
(2000)
J. Natl. Cancer Inst.
, vol.92
, Issue.19
, pp. 1564-1572
-
-
Jolly, C.1
Morimoto, R.I.2
-
82
-
-
78649346692
-
The heat shock response: Life on the verge of death
-
Richter, K.; Haslbeck, M.; Buchner, J. The heat shock response: life on the verge of death. Mol. Cell, 2010, 40(2), 253-266.
-
(2010)
Mol. Cell
, vol.40
, Issue.2
, pp. 253-266
-
-
Richter, K.1
Haslbeck, M.2
Buchner, J.3
-
83
-
-
0032535245
-
Regulation of the heat shock transcriptional response: Cross talk between a family of heat shock factors, molecular chaperones, and negative regulators
-
Morimoto, R.I. Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. Genes Dev., 1998, 12(24), 3788-3796.
-
(1998)
Genes Dev
, vol.12
, Issue.24
, pp. 3788-3796
-
-
Morimoto, R.I.1
-
84
-
-
41949129594
-
Heat shock response relieves ER stress
-
Liu, Y.; Chang, A. Heat shock response relieves ER stress. EMBO J., 2008, 27(7), 1049-1059.
-
(2008)
EMBO J
, vol.27
, Issue.7
, pp. 1049-1059
-
-
Liu, Y.1
Chang, A.2
-
85
-
-
18744382408
-
Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha
-
Marcu, M.G.; Doyle, M.; Bertolotti, A.; Ron, D.; Hender-shot, L.; Neckers, L. Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha. Mol. Cell. Biol., 2002, 22(24), 8506-8513.
-
(2002)
Mol. Cell. Biol.
, vol.22
, Issue.24
, pp. 8506-8513
-
-
Marcu, M.G.1
Doyle, M.2
Bertolotti, A.3
Ron, D.4
Hender-Shot, L.5
Neckers, L.6
-
86
-
-
84884593127
-
Proteasomes activate aggresome disassembly and clearance by producing unanchored ubiquitin chains
-
Hao, R.; Nanduri, P.; Rao, Y.; Panichelli, R.S.; Ito, A.; Yoshida, M.; Yao, T.P. Proteasomes activate aggresome disassembly and clearance by producing unanchored ubiquitin chains. Mol. Cell, 2013, 51(6), 819-828.
-
(2013)
Mol. Cell
, vol.51
, Issue.6
, pp. 819-828
-
-
Hao, R.1
Nanduri, P.2
Rao, Y.3
Panichelli, R.S.4
Ito, A.5
Yoshida, M.6
Yao, T.P.7
-
87
-
-
84927139452
-
Chaperone-mediated 26S proteasome remodeling facilitates free K63 ubiquitin chain production and aggresome clearance
-
Nanduri, P.; Hao, R.; Fitzpatrick, T.; Yao, T.P. Chaperone-mediated 26S proteasome remodeling facilitates free K63 ubiquitin chain production and aggresome clearance. J. Biol. Chem., 2015, 290(15), 9455-9464.
-
(2015)
J. Biol. Chem.
, vol.290
, Issue.15
, pp. 9455-9464
-
-
Nanduri, P.1
Hao, R.2
Fitzpatrick, T.3
Yao, T.P.4
-
88
-
-
77449157041
-
Crosstalk between Hsp70 molecular chaperone, lysosomes and proteasomes in auto-phagy-mediated proteolysis in human retinal pigment epithelial cells
-
Ryhänen, T.; Hyttinen, J.M.; Kopitz, J.; Rilla, K.; Kuusisto, E.; Mannermaa, E.; Viiri, J.; Holmberg, C.I.; Immonen, I.; Meri, S.; Parkkinen, J.; Eskelinen, E.L.; Uusitalo, H.; Salminen, A.; Kaarniranta, K. Crosstalk between Hsp70 molecular chaperone, lysosomes and proteasomes in auto-phagy-mediated proteolysis in human retinal pigment epithelial cells. J. Cell. Mol. Med., 2009, 13(9B), 3616-3631.
-
(2009)
J. Cell. Mol. Med.
, vol.13
, Issue.9B
, pp. 3616-3631
-
-
Ryhänen, T.1
Hyttinen, J.M.2
Kopitz, J.3
Rilla, K.4
Kuusisto, E.5
Mannermaa, E.6
Viiri, J.7
Holmberg, C.I.8
Immonen, I.9
Meri, S.10
Parkkinen, J.11
Eskelinen, E.L.12
Uusitalo, H.13
Salminen, A.14
Kaarniranta, K.15
-
89
-
-
0030802287
-
Molecular chaperones and the cytoskeleton
-
Liang, P.; MacRae, T.H. Molecular chaperones and the cytoskeleton. J. Cell Sci., 1997, 110(Pt 13), 1431-1440.
-
(1997)
J. Cell Sci.
, vol.110
, pp. 1431-1440
-
-
Liang, P.1
Macrae, T.H.2
-
90
-
-
0022379715
-
Morphological study of the mammalian stress response: Characterization of changes in cytoplasmic organelles, cytoskeleton, and nucleoli, and appearance of intranuclear actin filaments in rat fibroblasts after heat-shock treatment
-
Welch, W.J.; Suhan, J.P. Morphological study of the mammalian stress response: characterization of changes in cytoplasmic organelles, cytoskeleton, and nucleoli, and appearance of intranuclear actin filaments in rat fibroblasts after heat-shock treatment. J. Cell Biol., 1985, 101(4), 1198-1211.
-
(1985)
J. Cell Biol.
, vol.101
, Issue.4
, pp. 1198-1211
-
-
Welch, W.J.1
Suhan, J.P.2
-
91
-
-
5644259582
-
Involvement of tumor necrosis factor receptor-associated protein 1 (TRAP1) in apoptosis induced by beta-hydroxy-isovalerylshikonin
-
Masuda, Y.; Shima, G.; Aiuchi, T.; Horie, M.; Hori, K.; Nakajo, S.; Kajimoto, S.; Shibayama-Imazu, T.; Nakaya, K. Involvement of tumor necrosis factor receptor-associated protein 1 (TRAP1) in apoptosis induced by beta-hydroxy-isovalerylshikonin. J. Biol. Chem., 2004, 279(41), 42503-42515.
-
(2004)
J. Biol. Chem.
, vol.279
, Issue.41
, pp. 42503-42515
-
-
Masuda, Y.1
Shima, G.2
Aiuchi, T.3
Horie, M.4
Hori, K.5
Nakajo, S.6
Kajimoto, S.7
Shibayama-Imazu, T.8
Nakaya, K.9
-
92
-
-
4344651318
-
Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization
-
Nylandsted, J.; Gyrd-Hansen, M.; Danielewicz, A.; Fehrenbacher, N.; Lademann, U.; Høyer-Hansen, M.; Weber, E.; Multhoff, G.; Rohde, M.; Jäättelä, M. Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization. J. Exp. Med., 2004, 200(4), 425-435.
-
(2004)
J. Exp. Med.
, vol.200
, Issue.4
, pp. 425-435
-
-
Nylandsted, J.1
Gyrd-Hansen, M.2
Danielewicz, A.3
Fehrenbacher, N.4
Lademann, U.5
Høyer-Hansen, M.6
Weber, E.7
Multhoff, G.8
Rohde, M.9
Jäättelä, M.10
-
93
-
-
46149125267
-
Mem-brane-associated stress proteins: More than simply chaperones
-
Horváth, I.; Multhoff, G.; Sonnleitner, A.; Vígh, L. Mem-brane-associated stress proteins: more than simply chaperones. Biochim. Biophys. Acta, 2008, 1778(7-8), 1653-1664.
-
(2008)
Biochim. Biophys. Acta
, vol.1778
, Issue.7-8
, pp. 1653-1664
-
-
Horváth, I.1
Multhoff, G.2
Sonnleitner, A.3
Vígh, L.4
-
94
-
-
1642471825
-
Heat-shock proteins as regulators of apoptosis
-
Takayama, S.; Reed, J.C.; Homma, S. Heat-shock proteins as regulators of apoptosis. Oncogene, 2003, 22(56), 9041-9047.
-
(2003)
Oncogene
, vol.22
, Issue.56
, pp. 9041-9047
-
-
Takayama, S.1
Reed, J.C.2
Homma, S.3
-
95
-
-
39349083915
-
Adapting proteostasis for disease intervention
-
Balch, W.E.; Morimoto, R.I.; Dillin, A.; Kelly, J.W. Adapting proteostasis for disease intervention. Science, 2008, 319(5865), 916-919.
-
(2008)
Science
, vol.319
, Issue.5865
, pp. 916-919
-
-
Balch, W.E.1
Morimoto, R.I.2
Dillin, A.3
Kelly, J.W.4
-
96
-
-
53149094022
-
Heat shock proteins in animal neoplasms and human tumours--a comparison
-
Romanucci, M.; Bastow, T.; Della Salda, L. Heat shock proteins in animal neoplasms and human tumours--a comparison. Cell Stress Chaperones, 2008, 13(3), 253-262.
-
(2008)
Cell Stress Chaperones
, vol.13
, Issue.3
, pp. 253-262
-
-
Romanucci, M.1
Bastow, T.2
della Salda, L.3
-
97
-
-
84922479583
-
Cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. 3. Orchestrating the unfolded protein response in oncogenesis: An update
-
Manié, S.N.; Lebeau, J.; Chevet, E. Cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. 3. Orchestrating the unfolded protein response in oncogenesis: an update. Am. J. Physiol. Cell Physiol., 2014, 307(10), C901-C907.
-
(2014)
Am. J. Physiol. Cell Physiol.
, vol.307
, Issue.10
, pp. C901-C907
-
-
Manié, S.N.1
Lebeau, J.2
Chevet, E.3
-
98
-
-
84975796689
-
Endoplasmic reticulum stress-activated cell reprogramming in oncogenesis
-
Chevet, E.; Hetz, C.; Samali, A. Endoplasmic reticulum stress-activated cell reprogramming in oncogenesis. Cancer Discov., 2015, 5(6), 586-597.
-
(2015)
Cancer Discov
, vol.5
, Issue.6
, pp. 586-597
-
-
Chevet, E.1
Hetz, C.2
Samali, A.3
-
99
-
-
0033944777
-
Heat shock pro-teins--modulators of apoptosis in tumour cells
-
Creagh, E.M.; Sheehan, D.; Cotter, T.G. Heat shock pro-teins--modulators of apoptosis in tumour cells. Leukemia, 2000, 14(7), 1161-1173.
-
(2000)
Leukemia
, vol.14
, Issue.7
, pp. 1161-1173
-
-
Creagh, E.M.1
Sheehan, D.2
Cotter, T.G.3
-
100
-
-
0034608892
-
Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2
-
Nylandsted, J.; Rohde, M.; Brand, K.; Bastholm, L.; Elling, F.; Jäättelä, M. Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2. Proc. Natl. Acad. Sci. USA, 2000, 97(14), 7871-7876.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, Issue.14
, pp. 7871-7876
-
-
Nylandsted, J.1
Rohde, M.2
Brand, K.3
Bastholm, L.4
Elling, F.5
Jäättelä, M.6
-
101
-
-
33645969294
-
Heat shock proteins: Endogenous modulators of apoptotic cell death
-
Didelot, C.; Schmitt, E.; Brunet, M.; Maingret, L.; Parcellier, A.; Garrido, C. Heat shock proteins: endogenous modulators of apoptotic cell death. Handb. Exp. Pharmacol, 2006, 172, 171-98.
-
(2006)
Handb. Exp. Pharmacol
, vol.172
, pp. 171-198
-
-
Didelot, C.1
Schmitt, E.2
Brunet, M.3
Maingret, L.4
Parcellier, A.5
Garrido, C.6
-
102
-
-
84876084273
-
Targeting heat shock proteins in cancer
-
Jego, G.; Hazoumé, A.; Seigneuric, R.; Garrido, C. Targeting heat shock proteins in cancer. Cancer Lett., 2013, 332(2), 275-285.
-
(2013)
Cancer Lett
, vol.332
, Issue.2
, pp. 275-285
-
-
Jego, G.1
Hazoumé, A.2
Seigneuric, R.3
Garrido, C.4
-
104
-
-
34249805172
-
Expression of heat shock protein 70 (HSP70) in patients with colorectal adenocarci-noma--immunohistochemistry and Western blot analysis
-
Milićević, Z.T.; Petković, M.Z.; Drndarević, N.C.; Pavlović, M.D.; Todorović, V.N. Expression of heat shock protein 70 (HSP70) in patients with colorectal adenocarci-noma--immunohistochemistry and Western blot analysis. Neoplasma, 2007, 54(1), 37-45.
-
(2007)
Neoplasma
, vol.54
, Issue.1
, pp. 37-45
-
-
Milićević, Z.T.1
Petković, M.Z.2
Drndarević, N.C.3
Pavlović, M.D.4
Todorović, V.N.5
-
105
-
-
34548190284
-
Hsp70 response to 5-fluorouracil treatment in human colon cancer cell lines
-
Grivicich, I.; Regner, A.; Zanoni, C.; Correa, L.P.; Jotz, G.P.; Henriques, J.A.; Schwartsmann, G.; da Rocha, A.B. Hsp70 response to 5-fluorouracil treatment in human colon cancer cell lines. Int. J. Colorectal Dis., 2007, 22(10), 1201-1208.
-
(2007)
Int. J. Colorectal Dis.
, vol.22
, Issue.10
, pp. 1201-1208
-
-
Grivicich, I.1
Regner, A.2
Zanoni, C.3
Correa, L.P.4
Jotz, G.P.5
Henriques, J.A.6
Schwartsmann, G.7
da Rocha, A.B.8
-
106
-
-
0035829740
-
Selective depletion of inducible HSP70 enhances immu-nogenicity of rat colon cancer cells
-
Gurbuxani, S.; Bruey, J.M.; Fromentin, A.; Larmonier, N.; Parcellier, A.; Jäättelä, M.; Martin, F.; Solary, E.; Garrido, C. Selective depletion of inducible HSP70 enhances immu-nogenicity of rat colon cancer cells. Oncogene, 2001, 20(51), 7478-7485.
-
(2001)
Oncogene
, vol.20
, Issue.51
, pp. 7478-7485
-
-
Gurbuxani, S.1
Bruey, J.M.2
Fromentin, A.3
Larmonier, N.4
Parcellier, A.5
Jäättelä, M.6
Martin, F.7
Solary, E.8
Garrido, C.9
-
107
-
-
84891330477
-
The complex function of hsp70 in metastatic cancer
-
Juhasz, K.; Lipp, A.M.; Nimmervoll, B.; Sonnleitner, A.; Hesse, J.; Haselgruebler, T.; Balogi, Z. The complex function of hsp70 in metastatic cancer. Cancers (Basel), 2013, 6(1), 42-66.
-
(2013)
Cancers (Basel)
, vol.6
, Issue.1
, pp. 42-66
-
-
Juhasz, K.1
Lipp, A.M.2
Nimmervoll, B.3
Sonnleitner, A.4
Hesse, J.5
Haselgruebler, T.6
Balogi, Z.7
-
108
-
-
84940953620
-
Heat shock protein 60 levels in tissue and circulating exosomes in human large bowel cancer before and after ablative surgery
-
Campanella, C.; Rappa, F.; Sciumè, C.; Marino Gammazza, A.; Barone, R.; Bucchieri, F.; David, S.; Curcurù, G.; Caruso Bavisotto, C.; Pitruzzella, A.; Geraci, G.; Modica, G.; Farina, F.; Zummo, G.; Fais, S.; Conway de Macario, E.; Macario, A.J.; Cappello, F. Heat shock protein 60 levels in tissue and circulating exosomes in human large bowel cancer before and after ablative surgery. Cancer, 2015, 121(18), 3230-3239.
-
(2015)
Cancer
, vol.121
, Issue.18
, pp. 3230-3239
-
-
Campanella, C.1
Rappa, F.2
Sciumè, C.3
Marino Gammazza, A.4
Barone, R.5
Bucchieri, F.6
David, S.7
Curcurù, G.8
Caruso Bavisotto, C.9
Pitruzzella, A.10
Geraci, G.11
Modica, G.12
Farina, F.13
Zummo, G.14
Fais, S.15
Conway de Macario, E.16
Macario, A.J.17
Cappello, F.18
-
109
-
-
84864242842
-
High HSP27 and HSP70 expression levels are independent adverse prognostic factors in primary resected colon cancer
-
Bauer, K.; Nitsche, U.; Slotta-Huspenina, J.; Drecoll, E.; von Weyhern, C.H.; Rosenberg, R.; Höfler, H.; Langer, R. High HSP27 and HSP70 expression levels are independent adverse prognostic factors in primary resected colon cancer. Cell Oncol. (Dordr.), 2012, 35(3), 197-205.
-
(2012)
Cell Oncol. (Dordr.)
, vol.35
, Issue.3
, pp. 197-205
-
-
Bauer, K.1
Nitsche, U.2
Slotta-Huspenina, J.3
Drecoll, E.4
von Weyhern, C.H.5
Rosenberg, R.6
Höfler, H.7
Langer, R.8
-
110
-
-
79960337453
-
Heat shock proteins in oncology: Diagnostic biomarkers or therapeutic targets?
-
Khalil, A.A.; Kabapy, N.F.; Deraz, S.F.; Smith, C. Heat shock proteins in oncology: diagnostic biomarkers or therapeutic targets? Biochim. Biophys. Acta, 2011, 1816(2), 89-104.
-
(2011)
Biochim. Biophys. Acta
, vol.1816
, Issue.2
, pp. 89-104
-
-
Khalil, A.A.1
Kabapy, N.F.2
Deraz, S.F.3
Smith, C.4
-
111
-
-
82755186062
-
Identification and verification of heat shock protein 60 as a potential serum marker for colorectal cancer
-
Hamelin, C.; Cornut, E.; Poirier, F.; Pons, S.; Beaulieu, C.; Charrier, J.P.; Haïdous, H.; Cotte, E.; Lambert, C.; Piard, F.; Ataman-Önal, Y.; Choquet-Kastylevsky, G. Identification and verification of heat shock protein 60 as a potential serum marker for colorectal cancer. FEBS J., 2011, 278(24), 4845-4859.
-
(2011)
FEBS J
, vol.278
, Issue.24
, pp. 4845-4859
-
-
Hamelin, C.1
Cornut, E.2
Poirier, F.3
Pons, S.4
Beaulieu, C.5
Charrier, J.P.6
Haïdous, H.7
Cotte, E.8
Lambert, C.9
Piard, F.10
Ataman-Önal, Y.11
Choquet-Kastylevsky, G.12
-
112
-
-
81355142723
-
The proteomics of colorectal cancer: Identification of a protein signature associated with prognosis
-
O’Dwyer, D.; Ralton, L.D.; O’Shea, A.; Murray, G.I. The proteomics of colorectal cancer: identification of a protein signature associated with prognosis. PLoS One, 2011, 6(11), e27718.
-
(2011)
Plos One
, vol.6
, Issue.11
-
-
O’Dwyer, D.1
Ralton, L.D.2
O’Shea, A.3
Murray, G.I.4
-
113
-
-
33646259956
-
Detection and identification of heat shock protein 10 as a biomarker in colorectal cancer by protein profiling
-
Melle, C.; Bogumil, R.; Ernst, G.; Schimmel, B.; Bleul, A.; von Eggeling, F. Detection and identification of heat shock protein 10 as a biomarker in colorectal cancer by protein profiling. Proteomics, 2006, 6(8), 2600-2608.
-
(2006)
Proteomics
, vol.6
, Issue.8
, pp. 2600-2608
-
-
Melle, C.1
Bogumil, R.2
Ernst, G.3
Schimmel, B.4
Bleul, A.5
von Eggeling, F.6
-
114
-
-
68249119157
-
Heat shock protein 27 as a new therapeutic target for radiation sensitization of head and neck squamous cell carcinoma
-
Hadchity, E.; Aloy, M.T.; Paulin, C.; Armandy, E.; Watkin, E.; Rousson, R.; Gleave, M.; Chapet, O.; Rodriguez-Lafrasse, C. Heat shock protein 27 as a new therapeutic target for radiation sensitization of head and neck squamous cell carcinoma. Mol. Ther., 2009, 17(8), 1387-1394.
-
(2009)
Mol. Ther.
, vol.17
, Issue.8
, pp. 1387-1394
-
-
Hadchity, E.1
Aloy, M.T.2
Paulin, C.3
Armandy, E.4
Watkin, E.5
Rousson, R.6
Gleave, M.7
Chapet, O.8
Rodriguez-Lafrasse, C.9
-
115
-
-
84055190763
-
The heat shock proteins as targets for radiosensitization and chemosensitization in cancer
-
Guttmann, D.M.; Koumenis, C. The heat shock proteins as targets for radiosensitization and chemosensitization in cancer. Cancer Biol. Ther., 2011, 12(12), 1023-1031.
-
(2011)
Cancer Biol. Ther.
, vol.12
, Issue.12
, pp. 1023-1031
-
-
Guttmann, D.M.1
Koumenis, C.2
-
116
-
-
0027503365
-
Heat shock protein hsp70 in patients with axillary lymph node-negative breast cancer: Prognostic implications
-
Ciocca, D.R.; Clark, G.M.; Tandon, A.K.; Fuqua, S.A.; Welch, W.J.; McGuire, W.L. Heat shock protein hsp70 in patients with axillary lymph node-negative breast cancer: prognostic implications. J. Natl. Cancer Inst., 1993, 85(7), 570-574.
-
(1993)
J. Natl. Cancer Inst.
, vol.85
, Issue.7
, pp. 570-574
-
-
Ciocca, D.R.1
Clark, G.M.2
Tandon, A.K.3
Fuqua, S.A.4
Welch, W.J.5
McGuire, W.L.6
-
117
-
-
84876167357
-
The significance of heat shock proteins in breast cancer therapy
-
Oskay Halacli, S.; Halacli, B.; Altundag, K. The significance of heat shock proteins in breast cancer therapy. Med. Oncol., 2013, 30(2), 575.
-
(2013)
Med. Oncol.
, vol.30
, Issue.2
, pp. 575
-
-
Oskay Halacli, S.1
Halacli, B.2
Altundag, K.3
-
118
-
-
14644435819
-
Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanisms
-
Rohde, M.; Daugaard, M.; Jensen, M.H.; Helin, K.; Nylandsted, J.; Jäättelä, M. Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanisms. Genes Dev., 2005, 19(5), 570-582.
-
(2005)
Genes Dev
, vol.19
, Issue.5
, pp. 570-582
-
-
Rohde, M.1
Daugaard, M.2
Jensen, M.H.3
Helin, K.4
Nylandsted, J.5
Jäättelä, M.6
-
119
-
-
34249052540
-
Increased expression of HSP70 by colon cancer cells is not always associated with access to the dendritic cell cross-presentation pathway
-
Matera, L.; Forno, S.; Galetto, A.; Moro, F.; Garetto, S.; Mussa, A. Increased expression of HSP70 by colon cancer cells is not always associated with access to the dendritic cell cross-presentation pathway. Cell. Mol. Biol. Lett., 2007, 12(2), 268-279.
-
(2007)
Cell. Mol. Biol. Lett.
, vol.12
, Issue.2
, pp. 268-279
-
-
Matera, L.1
Forno, S.2
Galetto, A.3
Moro, F.4
Garetto, S.5
Mussa, A.6
-
120
-
-
78049519331
-
Low molecular weight heat shock protein HSP27 is a prognostic indicator in rectal cancer but not colon cancer
-
Tweedle, E.M.; Khattak, I.; Ang, C.W.; Nedjadi, T.; Jenkins, R.; Park, B.K.; Kalirai, H.; Dodson, A.; Azadeh, B.; Terlizzo, M.; Grabsch, H.; Mueller, W.; Myint, S.; Clark, P.; Wong, H.; Greenhalf, W.; Neoptolemos, J.P.; Rooney, P.S.; Costello, E. Low molecular weight heat shock protein HSP27 is a prognostic indicator in rectal cancer but not colon cancer. Gut, 2010, 59(11), 1501-1510.
-
(2010)
Gut
, vol.59
, Issue.11
, pp. 1501-1510
-
-
Tweedle, E.M.1
Khattak, I.2
Ang, C.W.3
Nedjadi, T.4
Jenkins, R.5
Park, B.K.6
Kalirai, H.7
Dodson, A.8
Azadeh, B.9
Terlizzo, M.10
Grabsch, H.11
Mueller, W.12
Myint, S.13
Clark, P.14
Wong, H.15
Greenhalf, W.16
Neoptolemos, J.P.17
Rooney, P.S.18
Costello, E.19
-
121
-
-
33746710376
-
Tissue microarray analysis of FAS, Bcl-2, Bcl-x, ER, PgR, Hsp60, p53 and Her2-neu in breast carcinoma
-
Sebastiani, V.; Botti, C.; Di Tondo, U.; Visca, P.; Pizzuti, L.; Santeusanio, G.; Alo, P.L. Tissue microarray analysis of FAS, Bcl-2, Bcl-x, ER, PgR, Hsp60, p53 and Her2-neu in breast carcinoma. Anticancer Res., 2006, 26(4B), 2983-2987.
-
(2006)
Anticancer Res.
, vol.26
, Issue.4B
, pp. 2983-2987
-
-
Sebastiani, V.1
Botti, C.2
Di Tondo, U.3
Visca, P.4
Pizzuti, L.5
Santeusanio, G.6
Alo, P.L.7
-
122
-
-
30444447791
-
Differential expression of Janus kinase 3 (JAK3), matrix metal-loproteinase 13 (MMP13), heat shock protein 60 (HSP60), and mouse double minute 2 (MDM2) in human colorectal cancer progression using human cancer cDNA microarrays
-
Mori, D.; Nakafusa, Y.; Miyazaki, K.; Tokunaga, O. Differential expression of Janus kinase 3 (JAK3), matrix metal-loproteinase 13 (MMP13), heat shock protein 60 (HSP60), and mouse double minute 2 (MDM2) in human colorectal cancer progression using human cancer cDNA microarrays. Pathol. Res. Pract., 2005, 201(12), 777-789.
-
(2005)
Pathol. Res. Pract.
, vol.201
, Issue.12
, pp. 777-789
-
-
Mori, D.1
Nakafusa, Y.2
Miyazaki, K.3
Tokunaga, O.4
-
123
-
-
0038662800
-
60KDa chaperonin (HSP60) is over-expressed during colorectal carcinogenesis
-
Cappello, F.; Bellafiore, M.; Palma, A.; David, S.; Marcianò, V.; Bartolotta, T.; Sciumè, C.; Modica, G.; Farina, F.; Zummo, G.; Bucchieri, F. 60KDa chaperonin (HSP60) is over-expressed during colorectal carcinogenesis. Eur. J. Histochem., 2003, 47(2), 105-110.
-
(2003)
Eur. J. Histochem.
, vol.47
, Issue.2
, pp. 105-110
-
-
Cappello, F.1
Bellafiore, M.2
Palma, A.3
David, S.4
Marcianò, V.5
Bartolotta, T.6
Sciumè, C.7
Modica, G.8
Farina, F.9
Zummo, G.10
Bucchieri, F.11
-
124
-
-
27744520377
-
The expression of HSP60 and HSP10 in large bowel carcinomas with lymph node metastase
-
Cappello, F.; David, S.; Rappa, F.; Bucchieri, F.; Marasà, L.; Bartolotta, T.E.; Farina, F.; Zummo, G. The expression of HSP60 and HSP10 in large bowel carcinomas with lymph node metastase. BMC Cancer, 2005, 5, 139.
-
(2005)
BMC Cancer
, vol.5
, pp. 139
-
-
Cappello, F.1
David, S.2
Rappa, F.3
Bucchieri, F.4
Marasà, L.5
Bartolotta, T.E.6
Farina, F.7
Zummo, G.8
-
125
-
-
38149095001
-
Proteomics-based identification of HSP60 as a tumor-associated antigen in colorectal cancer
-
He, Y.; Wu, Y.; Mou, Z.; Li, W.; Zou, L.; Fu, T.; Zhang, A.; Xiang, D.; Xiao, H.; Wang, X. Proteomics-based identification of HSP60 as a tumor-associated antigen in colorectal cancer. Proteomics Clin. Appl., 2007, 1(3), 336-342.
-
(2007)
Proteomics Clin. Appl.
, vol.1
, Issue.3
, pp. 336-342
-
-
He, Y.1
Wu, Y.2
Mou, Z.3
Li, W.4
Zou, L.5
Fu, T.6
Zhang, A.7
Xiang, D.8
Xiao, H.9
Wang, X.10
-
126
-
-
84878964181
-
The HSP70 family and cancer
-
Murphy, M.E. The HSP70 family and cancer. Carcinogenesis, 2013, 34(6), 1181-1188.
-
(2013)
Carcinogenesis
, vol.34
, Issue.6
, pp. 1181-1188
-
-
Murphy, M.E.1
-
127
-
-
84901437711
-
Expression analysis of heat shock protein 90 (HSP90) and Her2 in colon carcinoma
-
Drecoll, E.; Nitsche, U.; Bauer, K.; Berezowska, S.; Slotta-Huspenina, J.; Rosenberg, R.; Langer, R. Expression analysis of heat shock protein 90 (HSP90) and Her2 in colon carcinoma. Int. J. Colorectal Dis., 2014, 29(6), 663-671.
-
(2014)
Int. J. Colorectal Dis.
, vol.29
, Issue.6
, pp. 663-671
-
-
Drecoll, E.1
Nitsche, U.2
Bauer, K.3
Berezowska, S.4
Slotta-Huspenina, J.5
Rosenberg, R.6
Langer, R.7
-
128
-
-
84884341253
-
Combining trail with PI3 kinase or HSP90 inhibitors enhances apoptosis in colorectal cancer cells via suppression of survival signaling
-
Saturno, G.; Valenti, M.; De Haven Brandon, A.; Thomas, G.V.; Eccles, S.; Clarke, P.A.; Workman, P. Combining trail with PI3 kinase or HSP90 inhibitors enhances apoptosis in colorectal cancer cells via suppression of survival signaling. Oncotarget, 2013, 4(8), 1185-1198.
-
(2013)
Oncotarget
, vol.4
, Issue.8
, pp. 1185-1198
-
-
Saturno, G.1
Valenti, M.2
de Haven Brandon, A.3
Thomas, G.V.4
Eccles, S.5
Clarke, P.A.6
Workman, P.7
-
129
-
-
36749061389
-
Blocking heat shock protein-90 inhibits the invasive properties and hepatic growth of human colon cancer cells and improves the efficacy of oxaliplatin in p53-deficient colon cancer tumors in vivo
-
Moser, C.; Lang, S.A.; Kainz, S.; Gaumann, A.; Fichtner-Feigl, S.; Koehl, G.E.; Schlitt, H.J.; Geissler, E.K.; Stoeltz-ing, O. Blocking heat shock protein-90 inhibits the invasive properties and hepatic growth of human colon cancer cells and improves the efficacy of oxaliplatin in p53-deficient colon cancer tumors in vivo. Mol. Cancer Ther., 2007, 6(11), 2868-2878.
-
(2007)
Mol. Cancer Ther.
, vol.6
, Issue.11
, pp. 2868-2878
-
-
Moser, C.1
Lang, S.A.2
Kainz, S.3
Gaumann, A.4
Fichtner-Feigl, S.5
Koehl, G.E.6
Schlitt, H.J.7
Geissler, E.K.8
Stoeltz-Ing, O.9
-
130
-
-
80051593469
-
Identification of heat shock protein 90α as an IMH-2 epi-tope-associated protein and correlation of its mRNA over- expression with colorectal cancer metastasis and poor prognosis
-
Chen, W-S.; Lee, C-C.; Hsu, Y-M.; Chen, C-C.; Huang, T-S. Identification of heat shock protein 90α as an IMH-2 epi-tope-associated protein and correlation of its mRNA over- expression with colorectal cancer metastasis and poor prognosis. Int. J. Colorectal Dis., 2011, 26(8), 1009-1017.
-
(2011)
Int. J. Colorectal Dis.
, vol.26
, Issue.8
, pp. 1009-1017
-
-
Chen, W.-S.1
Lee, C.-C.2
Hsu, Y.-M.3
Chen, C.-C.4
Huang, T.-S.5
-
131
-
-
25844519550
-
HSP90 and the chaperoning of cancer
-
Whitesell, L.; Lindquist, S.L. HSP90 and the chaperoning of cancer. Nat. Rev. Cancer, 2005, 5(10), 761-772.
-
(2005)
Nat. Rev. Cancer
, vol.5
, Issue.10
, pp. 761-772
-
-
Whitesell, L.1
Lindquist, S.L.2
-
132
-
-
0038069088
-
Gel-danamycin and its 17-allylamino-17-demethoxy analogue antagonize the action of Cisplatin in human colon adenocarcinoma cells: Differential caspase activation as a basis for interaction
-
Vasilevskaya, I.A.; Rakitina, T.V.; O’Dwyer, P.J. Gel-danamycin and its 17-allylamino-17-demethoxy analogue antagonize the action of Cisplatin in human colon adenocarcinoma cells: differential caspase activation as a basis for interaction. Cancer Res., 2003, 63(12), 3241-3246.
-
(2003)
Cancer Res.
, vol.63
, Issue.12
, pp. 3241-3246
-
-
Vasilevskaya, I.A.1
Rakitina, T.V.2
O’Dwyer, P.J.3
-
133
-
-
0034710542
-
Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of the hsp90 molecular chaperone
-
Clarke, P.A.; Hostein, I.; Banerji, U.; Stefano, F.D.; Ma-loney, A.; Walton, M.; Judson, I.; Workman, P. Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of the hsp90 molecular chaperone. Oncogene, 2000, 19(36), 4125-4133.
-
(2000)
Oncogene
, vol.19
, Issue.36
, pp. 4125-4133
-
-
Clarke, P.A.1
Hostein, I.2
Banerji, U.3
Stefano, F.D.4
Ma-Loney, A.5
Walton, M.6
Judson, I.7
Workman, P.8
-
134
-
-
84930197013
-
Co-chaperones of the mammalian endoplasmic reticulum
-
Melnyk, A.; Rieger, H.; Zimmermann, R. Co-chaperones of the mammalian endoplasmic reticulum. Subcell. Biochem., 2015, 78, 179-200.
-
(2015)
Subcell. Biochem.
, vol.78
, pp. 179-200
-
-
Melnyk, A.1
Rieger, H.2
Zimmermann, R.3
-
135
-
-
84886729941
-
Glucose-regulated protein 78 silencing down-regulates vascular endothelial growth factor/vascular endothelial growth factor receptor 2 pathway to suppress human colon cancer tumor growth
-
Kuo, L.J.; Hung, C.S.; Chen, W.Y.; Chang, Y.J.; Wei, P.L. Glucose-regulated protein 78 silencing down-regulates vascular endothelial growth factor/vascular endothelial growth factor receptor 2 pathway to suppress human colon cancer tumor growth. J. Surg. Res., 2013, 185(1), 264-272.
-
(2013)
J. Surg. Res.
, vol.185
, Issue.1
, pp. 264-272
-
-
Kuo, L.J.1
Hung, C.S.2
Chen, W.Y.3
Chang, Y.J.4
Wei, P.L.5
-
136
-
-
84870005734
-
Colon cancer cells expressing cell surface GRP78 as a marker for reduced tumorigenicity
-
Hardy, B.; Raiter, A.; Yakimov, M.; Vilkin, A.; Niv, Y. Colon cancer cells expressing cell surface GRP78 as a marker for reduced tumorigenicity. Cell Oncol. (Dordr.), 2012, 35(5), 345-354.
-
(2012)
Cell Oncol. (Dordr.)
, vol.35
, Issue.5
, pp. 345-354
-
-
Hardy, B.1
Raiter, A.2
Yakimov, M.3
Vilkin, A.4
Niv, Y.5
-
137
-
-
84930919042
-
Glucose-regulated protein 78 (GRP78) regulates colon cancer metastasis through EMT biomarkers and the NRF-2/HO-1 pathway
-
Chang, Y.J.; Chen, W.Y.; Huang, C.Y.; Liu, H.H.; Wei, P.L. Glucose-regulated protein 78 (GRP78) regulates colon cancer metastasis through EMT biomarkers and the NRF-2/HO-1 pathway. Tumour Biol., 2015, 36(3), 1859-1869.
-
(2015)
Tumour Biol
, vol.36
, Issue.3
, pp. 1859-1869
-
-
Chang, Y.J.1
Chen, W.Y.2
Huang, C.Y.3
Liu, H.H.4
Wei, P.L.5
-
138
-
-
84857491952
-
Colorectal cancer stem cells
-
Vaiopoulos, A.G.; Kostakis, I.D.; Koutsilieris, M.; Pa-pavassiliou, A.G. Colorectal cancer stem cells. Stem Cells, 2012, 30(3), 363-371.
-
(2012)
Stem Cells
, vol.30
, Issue.3
, pp. 363-371
-
-
Vaiopoulos, A.G.1
Kostakis, I.D.2
Koutsilieris, M.3
Pa-Pavassiliou, A.G.4
-
139
-
-
54249087106
-
Colon cancer stem cells: Implications for prevention and therapy
-
Huang, E.H.; Wicha, M.S. Colon cancer stem cells: implications for prevention and therapy. Trends Mol. Med., 2008, 14(11), 503-509.
-
(2008)
Trends Mol. Med.
, vol.14
, Issue.11
, pp. 503-509
-
-
Huang, E.H.1
Wicha, M.S.2
-
140
-
-
84898416242
-
Heat shock protein DNAJB8 is a novel target for immunotherapy of colon cancer-initiating cells
-
Morita, R.; Nishizawa, S.; Torigoe, T.; Takahashi, A.; Ta-mura, Y.; Tsukahara, T.; Kanaseki, T.; Sokolovskaya, A.; Kochin, V.; Kondo, T.; Hashino, S.; Asaka, M.; Hara, I.; Hirohashi, Y.; Sato, N. Heat shock protein DNAJB8 is a novel target for immunotherapy of colon cancer-initiating cells. Cancer Sci., 2014, 105(4), 389-395.
-
(2014)
Cancer Sci
, vol.105
, Issue.4
, pp. 389-395
-
-
Morita, R.1
Nishizawa, S.2
Torigoe, T.3
Takahashi, A.4
Ta-Mura, Y.5
Tsukahara, T.6
Kanaseki, T.7
Sokolovskaya, A.8
Kochin, V.9
Kondo, T.10
Hashino, S.11
Asaka, M.12
Hara, I.13
Hirohashi, Y.14
Sato, N.15
-
141
-
-
0027425062
-
Induction of cellular senescence by transfection of cytosolic mortalin cDNA in NIH 3T3 cells
-
Wadhwa, R.; Kaul, S.C.; Sugimoto, Y.; Mitsui, Y. Induction of cellular senescence by transfection of cytosolic mortalin cDNA in NIH 3T3 cells. J. Biol. Chem., 1993, 268(30), 22239-22242.
-
(1993)
J. Biol. Chem.
, vol.268
, Issue.30
, pp. 22239-22242
-
-
Wadhwa, R.1
Kaul, S.C.2
Sugimoto, Y.3
Mitsui, Y.4
-
142
-
-
33847651284
-
Three faces of mortalin: A housekeeper, guardian and killer
-
Kaul, S.C.; Deocaris, C.C.; Wadhwa, R. Three faces of mortalin: a housekeeper, guardian and killer. Exp. Gerontol., 2007, 42(4), 263-274.
-
(2007)
Exp. Gerontol.
, vol.42
, Issue.4
, pp. 263-274
-
-
Kaul, S.C.1
Deocaris, C.C.2
Wadhwa, R.3
-
143
-
-
0031443856
-
Induction of PBP74/mortalin/Grp75, a member of the hsp70 family, by low doses of ionizing radiation: A possible role in induced radioresistance
-
Sadekova, S.; Lehnert, S.; Chow, T.Y. Induction of PBP74/mortalin/Grp75, a member of the hsp70 family, by low doses of ionizing radiation: a possible role in induced radioresistance. Int. J. Radiat. Biol., 1997, 72(6), 653-660.
-
(1997)
Int. J. Radiat. Biol.
, vol.72
, Issue.6
, pp. 653-660
-
-
Sadekova, S.1
Lehnert, S.2
Chow, T.Y.3
-
144
-
-
17044387386
-
Hsp70 chaperones: Cellular functions and molecular mechanism
-
Mayer, M.P.; Bukau, B. Hsp70 chaperones: cellular functions and molecular mechanism. Cell. Mol. Life Sci., 2005, 62(6), 670-684.
-
(2005)
Cell. Mol. Life Sci.
, vol.62
, Issue.6
, pp. 670-684
-
-
Mayer, M.P.1
Bukau, B.2
-
145
-
-
0028046847
-
Mitochondrial protein import: Biochemical and genetic evidence for interaction of matrix hsp70 and the inner membrane protein MIM44
-
Rassow, J.; Maarse, A.C.; Krainer, E.; Kübrich, M.; Müller, H.; Meijer, M.; Craig, E.A.; Pfanner, N. Mitochondrial protein import: biochemical and genetic evidence for interaction of matrix hsp70 and the inner membrane protein MIM44. J. Cell Biol., 1994, 127(6 Pt 1), 1547-1556.
-
(1994)
J. Cell Biol.
, vol.127
, Issue.6
, pp. 1547-1556
-
-
Rassow, J.1
Maarse, A.C.2
Krainer, E.3
Kübrich, M.4
Müller, H.5
Meijer, M.6
Craig, E.A.7
Pfanner, N.8
-
146
-
-
0036343904
-
The protein import motor of mitochondria
-
Neupert, W.; Brunner, M. The protein import motor of mitochondria. Nat. Rev. Mol. Cell Biol., 2002, 3(8), 555-565.
-
(2002)
Nat. Rev. Mol. Cell Biol.
, vol.3
, Issue.8
, pp. 555-565
-
-
Neupert, W.1
Brunner, M.2
-
147
-
-
0024309756
-
SSC1, an essential member of the yeast HSP70 multigene family, en- codes a mitochondrial protein
-
Craig, E.A.; Kramer, J.; Shilling, J.; Werner-Washburne, M.; Holmes, S.; Kosic-Smithers, J.; Nicolet, C.M. SSC1, an essential member of the yeast HSP70 multigene family, en- codes a mitochondrial protein. Mol. Cell. Biol., 1989, 9(7), 3000-3008.
-
(1989)
Mol. Cell. Biol.
, vol.9
, Issue.7
, pp. 3000-3008
-
-
Craig, E.A.1
Kramer, J.2
Shilling, J.3
Werner-Washburne, M.4
Holmes, S.5
Kosic-Smithers, J.6
Nicolet, C.M.7
-
148
-
-
34247171756
-
Knockdown of mitochondrial heat shock protein 70 promotes progeria-like phenotypes in caenorhabditis elegans
-
Kimura, K.; Tanaka, N.; Nakamura, N.; Takano, S.; Oh-kuma, S. Knockdown of mitochondrial heat shock protein 70 promotes progeria-like phenotypes in caenorhabditis elegans. J. Biol. Chem., 2007, 282(8), 5910-5918.
-
(2007)
J. Biol. Chem.
, vol.282
, Issue.8
, pp. 5910-5918
-
-
Kimura, K.1
Tanaka, N.2
Nakamura, N.3
Takano, S.4
Oh-Kuma, S.5
-
149
-
-
84862905166
-
Cytoplasmic sequestration of the tumor suppressor p53 by a heat shock protein 70 family member, mortalin, in human colorectal adenocarcinoma cell lines
-
Gestl, E.E.; Anne Böttger, S. Cytoplasmic sequestration of the tumor suppressor p53 by a heat shock protein 70 family member, mortalin, in human colorectal adenocarcinoma cell lines. Biochem. Biophys. Res. Commun., 2012, 423(2), 411-416.
-
(2012)
Biochem. Biophys. Res. Commun.
, vol.423
, Issue.2
, pp. 411-416
-
-
Gestl, E.E.1
Anne Böttger, S.2
-
150
-
-
84876706133
-
Drugga-bility of mortalin for cancer and neuro-degenerative disorders
-
Deocaris, C.C.; Lu, W.J.; Kaul, S.C.; Wadhwa, R. Drugga-bility of mortalin for cancer and neuro-degenerative disorders. Curr. Pharm. Des., 2013, 19(3), 418-429.
-
(2013)
Curr. Pharm. Des.
, vol.19
, Issue.3
, pp. 418-429
-
-
Deocaris, C.C.1
Lu, W.J.2
Kaul, S.C.3
Wadhwa, R.4
-
151
-
-
84940580797
-
Mortalin (GRP75/HSPA9) upregulation promotes survival and proliferation of medullary thyroid carcinoma cells
-
Starenki, D.; Hong, S.K.; Lloyd, R.V.; Park, J.I. Mortalin (GRP75/HSPA9) upregulation promotes survival and proliferation of medullary thyroid carcinoma cells. Oncogene, 2015, 34(35), 4624-4634.
-
(2015)
Oncogene
, vol.34
, Issue.35
, pp. 4624-4634
-
-
Starenki, D.1
Hong, S.K.2
Lloyd, R.V.3
Park, J.I.4
-
152
-
-
84922621429
-
Sp1 regulates Raf/MEK/ERK-induced p21(CIP1) transcription in TP53-mutated cancer cells
-
Karkhanis, M.; Park, J.I. Sp1 regulates Raf/MEK/ERK-induced p21(CIP1) transcription in TP53-mutated cancer cells. Cell. Signal., 2015, 27(3), 479-486.
-
(2015)
Cell. Signal.
, vol.27
, Issue.3
, pp. 479-486
-
-
Karkhanis, M.1
Park, J.I.2
-
153
-
-
33846282393
-
PRAK is essential for ras-induced senescence and tumor suppression
-
Sun, P.; Yoshizuka, N.; New, L.; Moser, B.A.; Li, Y.; Liao, R.; Xie, C.; Chen, J.; Deng, Q.; Yamout, M.; Dong, M.Q.; Frangou, C.G.; Yates, J.R., III; Wright, P.E.; Han, J. PRAK is essential for ras-induced senescence and tumor suppression. Cell, 2007, 128(2), 295-308.
-
(2007)
Cell
, vol.128
, Issue.2
, pp. 295-308
-
-
Sun, P.1
Yoshizuka, N.2
New, L.3
Moser, B.A.4
Li, Y.5
Liao, R.6
Xie, C.7
Chen, J.8
Deng, Q.9
Yamout, M.10
Dong, M.Q.11
Frangou, C.G.12
Yates, J.R.13
Wright, P.E.14
Han, J.15
-
154
-
-
82555176456
-
Crosstalk between Raf/MEK/ERK and PI3K/AKT in suppression of Bax conformational change by Grp75 under glucose deprivation conditions
-
Yang, L.; Guo, W.; Zhang, Q.; Li, H.; Liu, X.; Yang, Y.; Zuo, J.; Liu, W. Crosstalk between Raf/MEK/ERK and PI3K/AKT in suppression of Bax conformational change by Grp75 under glucose deprivation conditions. J. Mol. Biol., 2011, 414(5), 654-666.
-
(2011)
J. Mol. Biol.
, vol.414
, Issue.5
, pp. 654-666
-
-
Yang, L.1
Guo, W.2
Zhang, Q.3
Li, H.4
Liu, X.5
Yang, Y.6
Zuo, J.7
Liu, W.8
-
155
-
-
84898462646
-
75 improves HSP90 inhibitor efficacy by enhancing p53-mediated apoptosis in hepatocellular carcinoma
-
Guo, W.; Yan, L.; Yang, L.; Liu, X.; e, Q.; Gao, P.; Ye, X.; Liu, W.; Zuo, J. Targeting GRP75 improves HSP90 inhibitor efficacy by enhancing p53-mediated apoptosis in hepatocellular carcinoma. PLoS One, 2014, 9(1), e85766.
-
(2014)
Plos One
, vol.9
, Issue.1
-
-
Guo, W.1
Yan, L.2
Yang, L.3
Liu, X.4
Gao, P.5
Ye, X.6
Liu, W.7
Zuo, J.8
Targeting, G.R.P.9
-
156
-
-
84901424236
-
Mortalin/GRP75 binds to complement C9 and plays a role in resistance to complement-dependent cytotoxicity
-
Saar Ray, M.; Moskovich, O.; Iosefson, O.; Fishelson, Z. Mortalin/GRP75 binds to complement C9 and plays a role in resistance to complement-dependent cytotoxicity. J. Biol. Chem., 2014, 289(21), 15014-15022.
-
(2014)
J. Biol. Chem.
, vol.289
, Issue.21
, pp. 15014-15022
-
-
Saar Ray, M.1
Moskovich, O.2
Iosefson, O.3
Fishelson, Z.4
-
157
-
-
84906980711
-
Identification and functional characterization of nuclear mortalin in human carcinogenesis
-
Ryu, J.; Kaul, Z.; Yoon, A.R.; Liu, Y.; Yaguchi, T.; Na, Y.; Ahn, H.M.; Gao, R.; Choi, I.K.; Yun, C.O.; Kaul, S.C.; Wadhwa, R. Identification and functional characterization of nuclear mortalin in human carcinogenesis. J. Biol. Chem., 2014, 289(36), 24832-24844.
-
(2014)
J. Biol. Chem.
, vol.289
, Issue.36
, pp. 24832-24844
-
-
Ryu, J.1
Kaul, Z.2
Yoon, A.R.3
Liu, Y.4
Yaguchi, T.5
Na, Y.6
Ahn, H.M.7
Gao, R.8
Choi, I.K.9
Yun, C.O.10
Kaul, S.C.11
Wadhwa, R.12
-
158
-
-
80052036411
-
Induction of mutant p53-dependent apoptosis in human hepatocellular carcinoma by targeting stress protein mortalin
-
Lu, W.J.; Lee, N.P.; Kaul, S.C.; Lan, F.; Poon, R.T.; Wadhwa, R.; Luk, J.M. Induction of mutant p53-dependent apoptosis in human hepatocellular carcinoma by targeting stress protein mortalin. Int. J. Cancer, 2011, 129(8), 1806-1814.
-
(2011)
Int. J. Cancer
, vol.129
, Issue.8
, pp. 1806-1814
-
-
Lu, W.J.1
Lee, N.P.2
Kaul, S.C.3
Lan, F.4
Poon, R.T.5
Wadhwa, R.6
Luk, J.M.7
-
159
-
-
28044449126
-
Death-signal-induced relocalization of cyclin-dependent kinase 11 to mitochondria
-
Feng, Y.; Ariza, M.E.; Goulet, A.C.; Shi, J.; Nelson, M.A. Death-signal-induced relocalization of cyclin-dependent kinase 11 to mitochondria. Biochem. J., 2005, 392(Pt 1), 65-73.
-
(2005)
Biochem. J.
, vol.392
, pp. 65-73
-
-
Feng, Y.1
Ariza, M.E.2
Goulet, A.C.3
Shi, J.4
Nelson, M.A.5
-
160
-
-
84994618255
-
Mortalin, apoptosis, and neurodegeneration
-
Londono, C.; Osorio, C.; Gama, V.; Alzate, O. Mortalin, apoptosis, and neurodegeneration. Biomolecules, 2012, 2(1), 143-164.
-
(2012)
Biomolecules
, vol.2
, Issue.1
, pp. 143-164
-
-
Londono, C.1
Osorio, C.2
Gama, V.3
Alzate, O.4
-
161
-
-
84908110262
-
Expression profiling of mitochondrial voltage-dependent anion chan-nel-1 associated genes predicts recurrence-free survival in human carcinomas
-
Ko, J.H.; Gu, W.; Lim, I.; Zhou, T.; Bang, H. Expression profiling of mitochondrial voltage-dependent anion chan-nel-1 associated genes predicts recurrence-free survival in human carcinomas. PLoS One, 2014, 9(10), e110094.
-
(2014)
Plos One
, vol.9
, Issue.10
-
-
Ko, J.H.1
Gu, W.2
Lim, I.3
Zhou, T.4
Bang, H.5
-
162
-
-
0036257364
-
Voltage-dependent anion-selective channel (VDAC) interacts with the dynein light chain Tctex1 and the heat-shock protein PBP74
-
Schwarzer, C.; Barnikol-Watanabe, S.; Thinnes, F.P.; Hilschmann, N. Voltage-dependent anion-selective channel (VDAC) interacts with the dynein light chain Tctex1 and the heat-shock protein PBP74. Int. J. Biochem. Cell Biol., 2002, 34(9), 1059-1070.
-
(2002)
Int. J. Biochem. Cell Biol.
, vol.34
, Issue.9
, pp. 1059-1070
-
-
Schwarzer, C.1
Barnikol-Watanabe, S.2
Thinnes, F.P.3
Hilschmann, N.4
-
163
-
-
84928790568
-
P66Shc as a switch in bringing about contrasting responses in cell growth: Impli- cations on cell proliferation and apoptosis
-
Bhat, S.S.; Anand, D.; Khanday, F.A. p66Shc as a switch in bringing about contrasting responses in cell growth: impli- cations on cell proliferation and apoptosis. Mol. Cancer, 2015, 14, 76.
-
(2015)
Mol. Cancer
, vol.14
, pp. 76
-
-
Bhat, S.S.1
Anand, D.2
Khanday, F.A.3
-
164
-
-
35348820034
-
P66 Shc tumor levels show a strong prognostic correlation with disease outcome in stage IIA colon cancer
-
Grossman, S.R.; Lyle, S.; Resnick, M.B.; Sabo, E.; Lis, R.T.; Rosinha, E.; Liu, Q.; Hsieh, C.C.; Bhat, G.; Frackel-ton, A.R., Jr; Hafer, L.J. p66 Shc tumor levels show a strong prognostic correlation with disease outcome in stage IIA colon cancer. Clin. Cancer Res., 2007, 13(19), 5798-5804.
-
(2007)
Clin. Cancer Res.
, vol.13
, Issue.19
, pp. 5798-5804
-
-
Grossman, S.R.1
Lyle, S.2
Resnick, M.B.3
Sabo, E.4
Lis, R.T.5
Rosinha, E.6
Liu, Q.7
Hsieh, C.C.8
Bhat, G.9
Frackel-Ton, A.R.10
Hafer, L.J.11
-
165
-
-
84904112339
-
The expression of p66Shc protein in benign, premalignant, and malignant gastrointestinal lesions
-
Liu, G.; Xie, B.; Gong, L.; Zhou, J.; Shu, G. The expression of p66Shc protein in benign, premalignant, and malignant gastrointestinal lesions. Pathol. Oncol. Res., 2014, 20(3), 733-739.
-
(2014)
Pathol. Oncol. Res.
, vol.20
, Issue.3
, pp. 733-739
-
-
Liu, G.1
Xie, B.2
Gong, L.3
Zhou, J.4
Shu, G.5
-
166
-
-
84904670850
-
SHetA2 interference with mortalin binding to p66shc and p53 identified using drug-conjugated magnetic microspheres
-
Benbrook, D.M.; Nammalwar, B.; Long, A.; Matsumoto, H.; Singh, A.; Bunce, R.A.; Berlin, K.D. SHetA2 interference with mortalin binding to p66shc and p53 identified using drug-conjugated magnetic microspheres. Invest. New Drugs, 2014, 32(3), 412-423.
-
(2014)
Invest. New Drugs
, vol.32
, Issue.3
, pp. 412-423
-
-
Benbrook, D.M.1
Nammalwar, B.2
Long, A.3
Matsumoto, H.4
Singh, A.5
Bunce, R.A.6
Berlin, K.D.7
-
167
-
-
2942584910
-
The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential
-
Orsini, F.; Migliaccio, E.; Moroni, M.; Contursi, C.; Raker, V.A.; Piccini, D.; Martin-Padura, I.; Pelliccia, G.; Trinei, M.; Bono, M.; Puri, C.; Tacchetti, C.; Ferrini, M.; Man-nucci, R.; Nicoletti, I.; Lanfrancone, L.; Giorgio, M.; Pelicci, P.G. The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential. J. Biol. Chem., 2004, 279(24), 25689-25695.
-
(2004)
J. Biol. Chem.
, vol.279
, Issue.24
, pp. 25689-25695
-
-
Orsini, F.1
Migliaccio, E.2
Moroni, M.3
Contursi, C.4
Raker, V.A.5
Piccini, D.6
Martin-Padura, I.7
Pelliccia, G.8
Trinei, M.9
Bono, M.10
Puri, C.11
Tacchetti, C.12
Ferrini, M.13
Man-Nucci, R.14
Nicoletti, I.15
Lanfrancone, L.16
Giorgio, M.17
Pelicci, P.G.18
-
168
-
-
0029917052
-
Heterogeneous nuclear ribonucleoprotein K is a transcription factor
-
Michelotti, E.F.; Michelotti, G.A.; Aronsohn, A.I.; Levens, D. Heterogeneous nuclear ribonucleoprotein K is a transcription factor. Mol. Cell. Biol., 1996, 16(5), 2350-2360.
-
(1996)
Mol. Cell. Biol.
, vol.16
, Issue.5
, pp. 2350-2360
-
-
Michelotti, E.F.1
Michelotti, G.A.2
Aronsohn, A.I.3
Levens, D.4
-
169
-
-
84878221242
-
Heterogeneous nuclear ribonucleoprotein K (HnRNP-K) promotes tumor metastasis by induction of genes involved in extracellular matrix, cell movement, and angiogenesis
-
Gao, R.; Yu, Y.; Inoue, A.; Widodo, N.; Kaul, S.C.; Wadhwa, R. Heterogeneous nuclear ribonucleoprotein K (hnRNP-K) promotes tumor metastasis by induction of genes involved in extracellular matrix, cell movement, and angiogenesis. J. Biol. Chem., 2013, 288(21), 15046-15056.
-
(2013)
J. Biol. Chem.
, vol.288
, Issue.21
, pp. 15046-15056
-
-
Gao, R.1
Yu, Y.2
Inoue, A.3
Widodo, N.4
Kaul, S.C.5
Wadhwa, R.6
-
170
-
-
84969565352
-
Stress chaperone mortalin contributes to epithelial-mesenchymal transition and cancer metastasis
-
Na, Y.; Kaul, S.C.; Ryu, J.; Lee, J.S.; Ahn, H.M.; Kaul, Z.; Kalra, R.S.; Li, L.; Widodo, N.; Yun, C.O.; Wadhwa, R. Stress chaperone mortalin contributes to epithelial-mesenchymal transition and cancer metastasis. Cancer Res., 2016, canres.2704.2015.
-
(2015)
Cancer Res., 2016, Canres
, pp. 2704
-
-
Na, Y.1
Kaul, S.C.2
Ryu, J.3
Lee, J.S.4
Ahn, H.M.5
Kaul, Z.6
Kalra, R.S.7
Li, L.8
Widodo, N.9
Yun, C.O.10
Wadhwa, R.11
-
171
-
-
0041563779
-
Obstacles to cancer immunotherapy: Expression of membrane complement regulatory proteins (mCRPs) in tumors
-
Fishelson, Z.; Donin, N.; Zell, S.; Schultz, S.; Kirschfink, M. Obstacles to cancer immunotherapy: expression of membrane complement regulatory proteins (mCRPs) in tumors. Mol. Immunol., 2003, 40(2-4), 109-123.
-
(2003)
Mol. Immunol.
, vol.40
, Issue.2-4
, pp. 109-123
-
-
Fishelson, Z.1
Donin, N.2
Zell, S.3
Schultz, S.4
Kirschfink, M.5
-
172
-
-
33646416462
-
Inhibition of decay-accelerating factor (CD55) attenuates prostate cancer growth and survival in vivo
-
Loberg, R.D.; Day, L.L.; Dunn, R.; Kalikin, L.M.; Pienta, K.J. Inhibition of decay-accelerating factor (CD55) attenuates prostate cancer growth and survival in vivo. Neoplasia, 2006, 8(1), 69-78.
-
(2006)
Neoplasia
, vol.8
, Issue.1
, pp. 69-78
-
-
Loberg, R.D.1
Day, L.L.2
Dunn, R.3
Kalikin, L.M.4
Pienta, K.J.5
-
173
-
-
36049050637
-
Down-regulation of CD55 and CD46 expression by anti-sense phosphorothioate oligonucleotides (S-ODNs) sensitizes tumour cells to complement attack
-
Zell, S.; Geis, N.; Rutz, R.; Schultz, S.; Giese, T.; Kirschfink, M. Down-regulation of CD55 and CD46 expression by anti-sense phosphorothioate oligonucleotides (S-ODNs) sensitizes tumour cells to complement attack. Clin. Exp. Immunol., 2007, 150(3), 576-584.
-
(2007)
Clin. Exp. Immunol.
, vol.150
, Issue.3
, pp. 576-584
-
-
Zell, S.1
Geis, N.2
Rutz, R.3
Schultz, S.4
Giese, T.5
Kirschfink, M.6
-
174
-
-
24144457748
-
Mortalin/GRP75 promotes release of membrane vesicles from immune attacked cells and protection from complement-mediated lysis
-
Pilzer, D.; Fishelson, Z. Mortalin/GRP75 promotes release of membrane vesicles from immune attacked cells and protection from complement-mediated lysis. Int. Immunol., 2005, 17(9), 1239-1248.
-
(2005)
Int. Immunol.
, vol.17
, Issue.9
, pp. 1239-1248
-
-
Pilzer, D.1
Fishelson, Z.2
-
175
-
-
74949095086
-
Mortalin inhibitors sensitize K562 leukemia cells to complement-dependent cytotoxicity
-
Pilzer, D.; Saar, M.; Koya, K.; Fishelson, Z. Mortalin inhibitors sensitize K562 leukemia cells to complement-dependent cytotoxicity. Int. J. Cancer, 2010, 126(6), 1428-1435.
-
(2010)
Int. J. Cancer
, vol.126
, Issue.6
, pp. 1428-1435
-
-
Pilzer, D.1
Saar, M.2
Koya, K.3
Fishelson, Z.4
-
176
-
-
84857232029
-
Withanone binds to mortalin and abrogates mortalin-p53 complex: Computational and experimental evidence
-
Grover, A.; Priyandoko, D.; Gao, R.; Shandilya, A.; Widodo, N.; Bisaria, V.S.; Kaul, S.C.; Wadhwa, R.; Sundar, D. Withanone binds to mortalin and abrogates mortalin-p53 complex: computational and experimental evidence. Int. J. Biochem. Cell Biol., 2012, 44(3), 496-504.
-
(2012)
Int. J. Biochem. Cell Biol.
, vol.44
, Issue.3
, pp. 496-504
-
-
Grover, A.1
Priyandoko, D.2
Gao, R.3
Shandilya, A.4
Widodo, N.5
Bisaria, V.S.6
Kaul, S.C.7
Wadhwa, R.8
Sundar, D.9
-
177
-
-
0034671731
-
Selective toxicity of MKT-077 to cancer cells is mediated by its bind- ing to the hsp70 family protein mot-2 and reactivation of p53 function
-
Wadhwa, R.; Sugihara, T.; Yoshida, A.; Nomura, H.; Reddel, R.R.; Simpson, R.; Maruta, H.; Kaul, S.C. Selective toxicity of MKT-077 to cancer cells is mediated by its bind- ing to the hsp70 family protein mot-2 and reactivation of p53 function. Cancer Res., 2000, 60(24), 6818-6821.
-
(2000)
Cancer Res
, vol.60
, Issue.24
, pp. 6818-6821
-
-
Wadhwa, R.1
Sugihara, T.2
Yoshida, A.3
Nomura, H.4
Reddel, R.R.5
Simpson, R.6
Maruta, H.7
Kaul, S.C.8
-
178
-
-
84874083208
-
Identifications small molecules inhibitor of p53-mortalin complex for cancer drug using virtual screening
-
Utomo, D.H.; Widodo, N.; Rifa’i, M. Identifications small molecules inhibitor of p53-mortalin complex for cancer drug using virtual screening. Bioinformation, 2012, 8(9), 426-429.
-
(2012)
Bioinformation
, vol.8
, Issue.9
, pp. 426-429
-
-
Utomo, D.H.1
Widodo, N.2
Rifa’I, M.3
-
179
-
-
34249291074
-
Mortalin sensitizes human cancer cells to MKT-077-induced senescence
-
Deocaris, C.C.; Widodo, N.; Shrestha, B.G.; Kaur, K.; Ohtaka, M.; Yamasaki, K.; Kaul, S.C.; Wadhwa, R. Mortalin sensitizes human cancer cells to MKT-077-induced senescence. Cancer Lett., 2007, 252(2), 259-269.
-
(2007)
Cancer Lett
, vol.252
, Issue.2
, pp. 259-269
-
-
Deocaris, C.C.1
Widodo, N.2
Shrestha, B.G.3
Kaur, K.4
Ohtaka, M.5
Yamasaki, K.6
Kaul, S.C.7
Wadhwa, R.8
-
180
-
-
28244470279
-
Activation of wild type p53 function by its mortalin-binding, cytoplasmically localizing carboxyl terminus peptides
-
Kaul, S.C.; Aida, S.; Yaguchi, T.; Kaur, K.; Wadhwa, R. Activation of wild type p53 function by its mortalin-binding, cytoplasmically localizing carboxyl terminus peptides. J. Biol. Chem., 2005, 280(47), 39373-39379.
-
(2005)
J. Biol. Chem.
, vol.280
, Issue.47
, pp. 39373-39379
-
-
Kaul, S.C.1
Aida, S.2
Yaguchi, T.3
Kaur, K.4
Wadhwa, R.5
-
181
-
-
0030064081
-
Shishido,; Chen, L.B. MKT-077, a novel rhoda-cyanine dye in clinical trials, exhibits anticarcinoma activity in preclinical studies based on selective mitochondrial accumulation
-
Koya, K.; Li, Y.; Wang, H.; Ukai, T.; Tatsuta, N.; Kawa-kami, M.; Shishido,; Chen, L.B. MKT-077, a novel rhoda-cyanine dye in clinical trials, exhibits anticarcinoma activity in preclinical studies based on selective mitochondrial accumulation. Cancer Res., 1996, 56(3), 538-543.
-
(1996)
Cancer Res.
, vol.56
, Issue.3
, pp. 538-543
-
-
Koya, K.1
Li, Y.2
Wang, H.3
Ukai, T.4
Tatsuta, N.5
Kawa-Kami, M.6
-
182
-
-
63849172494
-
Identifying the proteins to which small-molecule probes and drugs bind in cells
-
Ong, S.E.; Schenone, M.; Margolin, A.A.; Li, X.; Do, K.; Doud, M.K.; Mani, D.R.; Kuai, L.; Wang, X.; Wood, J.L.; Tolliday, N.J.; Koehler, A.N.; Marcaurelle, L.A.; Golub, T.R.; Gould, R.J.; Schreiber, S.L.; Carr, S.A. Identifying the proteins to which small-molecule probes and drugs bind in cells. Proc. Natl. Acad. Sci. USA, 2009, 106(12), 4617-4622.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, Issue.12
, pp. 4617-4622
-
-
Ong, S.E.1
Schenone, M.2
Margolin, A.A.3
Li, X.4
Do, K.5
Doud, M.K.6
Mani, D.R.7
Kuai, L.8
Wang, X.9
Wood, J.L.10
Tolliday, N.J.11
Koehler, A.N.12
Marcaurelle, L.A.13
Golub, T.R.14
Gould, R.J.15
Schreiber, S.L.16
Carr, S.A.17
-
183
-
-
84855812283
-
Modulating protein-protein interactions with small molecules: The importance of binding hotspots
-
Thangudu, R.R.; Bryant, S.H.; Panchenko, A.R.; Madej, T. Modulating protein-protein interactions with small molecules: the importance of binding hotspots. J. Mol. Biol., 2012, 415(2), 443-453.
-
(2012)
J. Mol. Biol.
, vol.415
, Issue.2
, pp. 443-453
-
-
Thangudu, R.R.1
Bryant, S.H.2
Panchenko, A.R.3
Madej, T.4
-
184
-
-
84899964275
-
Hot spot-based design of small-molecule inhibitors for protein-protein interactions
-
Guo, W.; Wisniewski, J.A.; Ji, H. Hot spot-based design of small-molecule inhibitors for protein-protein interactions. Bioorg. Med. Chem. Lett., 2014, 24(11), 2546-2554.
-
(2014)
Bioorg. Med. Chem. Lett.
, vol.24
, Issue.11
, pp. 2546-2554
-
-
Guo, W.1
Wisniewski, J.A.2
Ji, H.3
-
185
-
-
84878411511
-
Cancer: Drug for an ‘undruggable’ protein
-
Baker, N.M.; Der, C.J. Cancer: Drug for an ‘undruggable’ protein. Nature, 2013, 497(7451), 577-578.
-
(2013)
Nature
, vol.497
, Issue.7451
, pp. 577-578
-
-
Baker, N.M.1
Der, C.J.2
-
186
-
-
58849145512
-
Predicting druggable binding sites at the protein-protein interface
-
Fuller, J.C.; Burgoyne, N.J.; Jackson, R.M. Predicting druggable binding sites at the protein-protein interface. Drug Discov. Today, 2009, 14(3-4), 155-161.
-
(2009)
Drug Discov. Today
, vol.14
, Issue.3-4
, pp. 155-161
-
-
Fuller, J.C.1
Burgoyne, N.J.2
Jackson, R.M.3
-
187
-
-
0034255499
-
Inactivation of wild-type p53 tumor suppressor by electrophilic prostaglandins
-
Moos, P.J.; Edes, K.; Fitzpatrick, F.A. Inactivation of wild-type p53 tumor suppressor by electrophilic prostaglandins. Proc. Natl. Acad. Sci. USA, 2000, 97(16), 9215-9220.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, Issue.16
, pp. 9215-9220
-
-
Moos, P.J.1
Edes, K.2
Fitzpatrick, F.A.3
-
188
-
-
0026523778
-
Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line
-
Shaw, P.; Bovey, R.; Tardy, S.; Sahli, R.; Sordat, B.; Costa, J. Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line. Proc. Natl. Acad. Sci. USA, 1992, 89(10), 4495-4499.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, Issue.10
, pp. 4495-4499
-
-
Shaw, P.1
Bovey, R.2
Tardy, S.3
Sahli, R.4
Sordat, B.5
Costa, J.6
-
189
-
-
0036605096
-
Prognostic significance of p53 mutations in colon cancer at the population level
-
Samowitz, W.S.; Curtin, K.; Ma, K.N.; Edwards, S.; Schaffer, D.; Leppert, M.F.; Slattery, M.L. Prognostic significance of p53 mutations in colon cancer at the population level. Int. J. Cancer, 2002, 99(4), 597-602.
-
(2002)
Int. J. Cancer
, vol.99
, Issue.4
, pp. 597-602
-
-
Samowitz, W.S.1
Curtin, K.2
Ma, K.N.3
Edwards, S.4
Schaffer, D.5
Leppert, M.F.6
Slattery, M.L.7
-
190
-
-
68249141901
-
Combination of p53 expression and p21 loss has an independent prognostic impact on sporadic colorectal cancer
-
Noske, A.; Lipka, S.; Budczies, J.; Müller, K.; Loddenkem-per, C.; Buhr, H.J.; Kruschewski, M. Combination of p53 expression and p21 loss has an independent prognostic impact on sporadic colorectal cancer. Oncol. Rep., 2009, 22(1), 3-9.
-
(2009)
Oncol. Rep.
, vol.22
, Issue.1
, pp. 3-9
-
-
Noske, A.1
Lipka, S.2
Budczies, J.3
Müller, K.4
Loddenkem-Per, C.5
Buhr, H.J.6
Kruschewski, M.7
-
191
-
-
42049101633
-
The cyclin-dependent kinase inhibitor flavopiridol potenti-ates the effects of topoisomerase I poisons by suppressing Rad51 expression in a p53-dependent manner
-
Ambrosini, G.; Seelman, S.L.; Qin, L.X.; Schwartz, G.K. The cyclin-dependent kinase inhibitor flavopiridol potenti-ates the effects of topoisomerase I poisons by suppressing Rad51 expression in a p53-dependent manner. Cancer Res., 2008, 68(7), 2312-2320.
-
(2008)
Cancer Res
, vol.68
, Issue.7
, pp. 2312-2320
-
-
Ambrosini, G.1
Seelman, S.L.2
Qin, L.X.3
Schwartz, G.K.4
-
192
-
-
84947730968
-
Nucleocytoplasmic Translocation of UBXN2A Is Required for Apoptosis during DNA Damage Stresses in Colon Cancer Cells
-
Abdullah, A.; Sane, S.; Freeling, J.L.; Wang, H.; Zhang, D.; Rezvani, K. Nucleocytoplasmic Translocation of UBXN2A Is Required for Apoptosis during DNA Damage Stresses in Colon Cancer Cells. J. Cancer, 2015, 6(11), 1066-1078.
-
(2015)
J. Cancer
, vol.6
, Issue.11
, pp. 1066-1078
-
-
Abdullah, A.1
Sane, S.2
Freeling, J.L.3
Wang, H.4
Zhang, D.5
Rezvani, K.6
-
193
-
-
85047219985
-
Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy
-
Sane, S.; Abdullah, A.; Nelson, M.E.; Wang, H.; Chauhan, S.C.; Newton, S.S.; Rezvani, K. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy. Cell Stress Chaperones, 2015.
-
(2015)
Cell Stress Chaperones
-
-
Sane, S.1
Abdullah, A.2
Nelson, M.E.3
Wang, H.4
Chauhan, S.C.5
Newton, S.S.6
Rezvani, K.7
-
194
-
-
0036569345
-
From UBA to UBX: New words in the ubiquitin vocabulary
-
Buchberger, A. From UBA to UBX: new words in the ubiquitin vocabulary. Trends Cell Biol., 2002, 12(5), 216-221.
-
(2002)
Trends Cell Biol
, vol.12
, Issue.5
, pp. 216-221
-
-
Buchberger, A.1
-
195
-
-
49249130739
-
UBX domain proteins: Major regulators of the AAA ATPase Cdc48/p97
-
Schuberth, C.; Buchberger, A. UBX domain proteins: major regulators of the AAA ATPase Cdc48/p97. Cell. Mol. Life Sci., 2008, 65(15), 2360-2371.
-
(2008)
Cell. Mol. Life Sci.
, vol.65
, Issue.15
, pp. 2360-2371
-
-
Schuberth, C.1
Buchberger, A.2
-
196
-
-
52649138958
-
UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover
-
Alexandru, G.; Graumann, J.; Smith, G.T.; Kolawa, N.J.; Fang, R.; Deshaies, R.J. UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover. Cell, 2008, 134(5), 804-816.
-
(2008)
Cell
, vol.134
, Issue.5
, pp. 804-816
-
-
Alexandru, G.1
Graumann, J.2
Smith, G.T.3
Kolawa, N.J.4
Fang, R.5
Deshaies, R.J.6
-
197
-
-
84874871591
-
Complex of Fas-associated factor 1 (FAF1) with valosin-containing protein (VCP)-Npl4-Ufd1 and polyubiquitinated proteins promotes endoplasmic reticu-lum-associated degradation (ERAD)
-
Lee, J.J.; Park, J.K.; Jeong, J.; Jeon, H.; Yoon, J.B.; Kim, E.E.; Lee, K.J. Complex of Fas-associated factor 1 (FAF1) with valosin-containing protein (VCP)-Npl4-Ufd1 and polyubiquitinated proteins promotes endoplasmic reticu-lum-associated degradation (ERAD). J. Biol. Chem., 2013, 288(10), 6998-7011.
-
(2013)
J. Biol. Chem.
, vol.288
, Issue.10
, pp. 6998-7011
-
-
Lee, J.J.1
Park, J.K.2
Jeong, J.3
Jeon, H.4
Yoon, J.B.5
Kim, E.E.6
Lee, K.J.7
-
198
-
-
27144535945
-
Ubx2 links the Cdc48 complex to ER-associated protein degradation
-
Neuber, O.; Jarosch, E.; Volkwein, C.; Walter, J.; Sommer, T. Ubx2 links the Cdc48 complex to ER-associated protein degradation. Nat. Cell Biol., 2005, 7(10), 993-998.
-
(2005)
Nat. Cell Biol.
, vol.7
, Issue.10
, pp. 993-998
-
-
Neuber, O.1
Jarosch, E.2
Volkwein, C.3
Walter, J.4
Sommer, T.5
-
199
-
-
84864419019
-
Ubiq-uitin-associated (UBA) domain in human Fas associated factor 1 inhibits tumor formation by promoting Hsp70 degradation
-
Lee, J.J.; Kim, Y.M.; Jeong, J.; Bae, D.S.; Lee, K.J. Ubiq-uitin-associated (UBA) domain in human Fas associated factor 1 inhibits tumor formation by promoting Hsp70 degradation. PLoS One, 2012, 7(8), e40361.
-
(2012)
Plos One
, vol.7
, Issue.8
-
-
Lee, J.J.1
Kim, Y.M.2
Jeong, J.3
Bae, D.S.4
Lee, K.J.5
-
200
-
-
84867032420
-
P47 negatively regulates IKK activation by inducing the lysosomal degradation of polyubiquitinated NEMO
-
Shibata, Y.; Oyama, M.; Kozuka-Hata, H.; Han, X.; Tanaka, Y.; Gohda, J.; Inoue, J. p47 negatively regulates IKK activation by inducing the lysosomal degradation of polyubiquitinated NEMO. Nat. Commun., 2012, 3, 1061.
-
(2012)
Nat. Commun.
, vol.3
, pp. 1061
-
-
Shibata, Y.1
Oyama, M.2
Kozuka-Hata, H.3
Han, X.4
Tanaka, Y.5
Gohda, J.6
Inoue, J.7
-
201
-
-
77952652312
-
The UBXN1 protein associates with autoubiquitinated forms of the BRCA1 tumor suppressor and inhibits its enzymatic function
-
Wu-Baer, F.; Ludwig, T.; Baer, R. The UBXN1 protein associates with autoubiquitinated forms of the BRCA1 tumor suppressor and inhibits its enzymatic function. Mol. Cell. Biol., 2010, 30(11), 2787-2798.
-
(2010)
Mol. Cell. Biol.
, vol.30
, Issue.11
, pp. 2787-2798
-
-
Wu-Baer, F.1
Ludwig, T.2
Baer, R.3
-
202
-
-
1842842116
-
Mortalin imaging in normal and cancer cells with quantum dot immuno-conjugates
-
Kaul, Z.; Yaguchi, T.; Kaul, S.C.; Hirano, T.; Wadhwa, R.; Taira, K. Mortalin imaging in normal and cancer cells with quantum dot immuno-conjugates. Cell Res., 2003, 13(6), 503-507.
-
(2003)
Cell Res
, vol.13
, Issue.6
, pp. 503-507
-
-
Kaul, Z.1
Yaguchi, T.2
Kaul, S.C.3
Hirano, T.4
Wadhwa, R.5
Taira, K.6
-
204
-
-
84931439004
-
-
Mortalin Biology: Life, Stress and Death; Wadhwa, R., Ed.; Springer Netherlands: Kaul, S. C
-
Gao, R.; Kaul, Z.; Yaguchi, T.; Wadhwa, R. Mortalin Staining Pattern as a Reporter for Cell Based Anti-Cancer Drug Screening. In: Mortalin Biology: Life, Stress and Death; Wadhwa, R., Ed.; Springer Netherlands: Kaul, S. C., 2012; pp. 307-322.
-
(2012)
Mortalin Staining Pattern as a Reporter for Cell Based Anti-Cancer Drug Screening
, pp. 307-322
-
-
Gao, R.1
Kaul, Z.2
Yaguchi, T.3
Wadhwa, R.4
-
205
-
-
84937546475
-
Targeting of DNA Damage Signaling Pathway Induced Senescence and Reduced Migration of Cancer cells
-
Gao, R.; Singh, R.; Kaul, Z.; Kaul, S.C.; Wadhwa, R. Targeting of DNA Damage Signaling Pathway Induced Senescence and Reduced Migration of Cancer cells. J. Gerontol. A Biol. Sci. Med. Sci., 2015, 70(6), 701-713.
-
(2015)
J. Gerontol. a Biol. Sci. Med. Sci.
, vol.70
, Issue.6
, pp. 701-713
-
-
Gao, R.1
Singh, R.2
Kaul, Z.3
Kaul, S.C.4
Wadhwa, R.5
-
206
-
-
0033569655
-
Fibroblast growth factor-1 interacts with the glucose-regulated protein GRP75/mortalin
-
Mizukoshi, E.; Suzuki, M.; Loupatov, A.; Uruno, T.; Haya-shi, H.; Misono, T.; Kaul, S.C.; Wadhwa, R.; Imamura, T. Fibroblast growth factor-1 interacts with the glucose-regulated protein GRP75/mortalin. Biochem. J., 1999, 343(Pt 2), 461-466.
-
(1999)
Biochem. J.
, vol.343
, pp. 461-466
-
-
Mizukoshi, E.1
Suzuki, M.2
Loupatov, A.3
Uruno, T.4
Haya-Shi, H.5
Misono, T.6
Kaul, S.C.7
Wadhwa, R.8
Imamura, T.9
-
207
-
-
0037459206
-
Mortalin-MPD (Mevalonate pyrophosphate decarboxy-lase) interactions and their role in control of cellular proliferation
-
Wadhwa, R.; Yaguchi, T.; Hasan, M.K.; Taira, K.; Kaul, S.C. Mortalin-MPD (mevalonate pyrophosphate decarboxy-lase) interactions and their role in control of cellular proliferation. Biochem. Biophys. Res. Commun., 2003, 302(4), 735-742.
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.302
, Issue.4
, pp. 735-742
-
-
Wadhwa, R.1
Yaguchi, T.2
Hasan, M.K.3
Taira, K.4
Kaul, S.C.5
-
208
-
-
0035879050
-
Identification and characterization of molecular interactions between glucose-regulated proteins (GRPs) mortalin/GRP75/ pep-tide-binding protein 74 (PBP74) and GRP94
-
Takano, S.; Wadhwa, R.; Mitsui, Y.; Kaul, S.C. Identification and characterization of molecular interactions between glucose-regulated proteins (GRPs) mortalin/GRP75/ pep-tide-binding protein 74 (PBP74) and GRP94. Biochem. J., 2001, 357(Pt 2), 393-398.
-
(2001)
Biochem. J.
, vol.357
, pp. 393-398
-
-
Takano, S.1
Wadhwa, R.2
Mitsui, Y.3
Kaul, S.C.4
|