-
1
-
-
84893416081
-
-
National Cancer Institute Surveillance Epidemiology and End Results Program. Accessed May 4
-
National Cancer Institute Surveillance, Epidemiology, and End Results Program. SEER stat fact sheets: colon and rectum cancer. http://seer.cancer.gov/statfacts/html/colorect.html. Accessed May 4, 2014
-
(2014)
SEER Stat Fact Sheets: Colon and Rectum Cancer.
-
-
-
3
-
-
0034712536
-
Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: A multicenter randomised trial
-
Douillard JY, Cunninghan D, Roth AD, et al. 2000. Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicenter randomised trial. Lancet 355:1041-47
-
(2000)
Lancet
, vol.355
, pp. 1041-1047
-
-
Douillard, J.Y.1
Cunninghan, D.2
Roth, A.D.3
-
4
-
-
0034727063
-
Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer irinotecan study group
-
SaltzLB, Cox JV, Blanke C, et al. 2000. Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group. N. Engl. J. Med. 343:905-14
-
(2000)
N. Engl. J. Med.
, vol.343
, pp. 905-914
-
-
Saltz, L.B.1
Cox, J.V.2
Blanke, C.3
-
5
-
-
24644432555
-
Phase iii study of weekly high-dose infusional fluorouracil plus folinic acid with or without irinotecan in patients with metastatic colorectal cancer: European organisation for research and treatment of cancer gastrointestinal group study 40986
-
Kohne CH, van Cutsem E, Wils J, et al. 2005. Phase III study of weekly high-dose infusional fluorouracil plus folinic acid with or without irinotecan in patients with metastatic colorectal cancer: European Organisation for Research and Treatment of Cancer Gastrointestinal Group Study 40986. J. Clin. Oncol. 23:4856-65
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 4856-4865
-
-
Kohne, C.H.1
Van Cutsem, E.2
Wils, J.3
-
6
-
-
0033874892
-
Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer
-
De Gramont A, Figer A, Seymour M, et al. 2000. Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. J. Clin. Oncol. 18:2938-47
-
(2000)
J. Clin. Oncol.
, vol.18
, pp. 2938-2947
-
-
De Gramont, A.1
Figer, A.2
Seymour, M.3
-
7
-
-
0033989203
-
Phase III multicenter randomized trial of oxaliplatin added to chronomodulated fluorouracil-leucovorin as first-line treatment of metastatic colorectal cancer
-
Giacchetti S, Perpoint B, Ziadani R, et al. 2000. Phase III multicenter randomized trial of oxaliplatin added to chronomodulated fluorouracil-leucovorin as first-line treatment of metastatic colorectal cancer. J. Clin. Oncol. 18:136-47
-
(2000)
J. Clin. Oncol.
, vol.18
, pp. 136-147
-
-
Giacchetti, S.1
Perpoint, B.2
Ziadani, R.3
-
8
-
-
1342290189
-
FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: A randomized GERCOR study
-
Tournigand C, Andre T, Achille E, et al. 2004. FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: a randomized GERCOR study. J. Clin. Oncol. 22:229-37
-
(2004)
J. Clin. Oncol.
, vol.22
, pp. 229-237
-
-
Tournigand, C.1
Andre, T.2
Achille, E.3
-
9
-
-
34249000361
-
Phase III trial of infusional fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) compared with infusional fluorouracil, leucovorin, and irinotecan (FOLFIRI) as first-line treatment for metastatic colorectal cancer: The Gruppo Oncologico Nord Ovest
-
Falcone A, Ricci S, Brunetti I, et al. 2007. Phase III trial of infusional fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) compared with infusional fluorouracil, leucovorin, and irinotecan (FOLFIRI) as first-line treatment for metastatic colorectal cancer: the Gruppo Oncologico Nord Ovest. J. Clin. Oncol. 25:1670-76
-
(2007)
J. Clin. Oncol.
, vol.25
, pp. 1670-1676
-
-
Falcone, A.1
Ricci, S.2
Brunetti, I.3
-
10
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil and leucovorin for metastatic colorectal cancer
-
Hurwitz H, Fehrenbacher L, Novotny W, et al. 2004. Bevacizumab plus irinotecan, fluorouracil and leucovorin for metastatic colorectal cancer. N. Engl. J. Med. 350(23):2335-42
-
(2004)
N. Engl. J. Med.
, vol.350
, Issue.23
, pp. 2335-2342
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
-
11
-
-
49049105525
-
Safety and efficacy of oxaliplatin and fluoropyrimidine regimens with or without bevacizumab as first-line treatment of metastatic colorectal cancer: Results of the TREE study
-
Hochster HS, Hart LL, Ramanathan RK, et al. 2008. Safety and efficacy of oxaliplatin and fluoropyrimidine regimens with or without bevacizumab as first-line treatment of metastatic colorectal cancer: results of the TREE study. J. Clin. Oncol. 26(21):3523-29
-
(2008)
J. Clin. Oncol.
, vol.26
, Issue.21
, pp. 3523-3529
-
-
Hochster, H.S.1
Hart, L.L.2
Ramanathan, R.K.3
-
12
-
-
42949149159
-
Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: A randomized phase III study
-
Saltz LB, Clarke S, Diaz-Rubio E, et al. 2008. Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study. J. Clin. Oncol. 26(12):2013-19
-
(2008)
J. Clin. Oncol.
, vol.26
, Issue.12
, pp. 2013-2019
-
-
Saltz, L.B.1
Clarke, S.2
Diaz-Rubio, E.3
-
13
-
-
84878468561
-
Capecitabine/irinotecan or capecitabine/oxaliplatin in combination with bevacizumab is effective and safe as first-line therapy for metastatic colorectal cancer: A randomized phase II study of the AIO colorectal study group
-
Schmiegel W, Reinacher-Schick A, Arnold D, et al. 2013. Capecitabine/irinotecan or capecitabine/oxaliplatin in combination with bevacizumab is effective and safe as first-line therapy for metastatic colorectal cancer: a randomized phase II study of the AIO colorectal study group. Ann. Oncol. 24(6):1580-87
-
(2013)
Ann. Oncol.
, vol.24
, Issue.6
, pp. 1580-1587
-
-
Schmiegel, W.1
Reinacher-Schick, A.2
Arnold, D.3
-
14
-
-
63849088630
-
Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
-
Van Cutsem E, Kohne CH, Hitre E, et al. 2009. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N. Engl. J. Med. 360(14):1408-17
-
(2009)
N. Engl. J. Med.
, vol.360
, Issue.14
, pp. 1408-1417
-
-
Van Cutsem, E.1
Kohne, C.H.2
Hitre, E.3
-
15
-
-
79956298812
-
Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: Updated analysis of overall survival according to tumor KRAS and BRAF mutation status
-
Van Cutsem E, Kohne CH, Lang I, et al. 2011. Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: updated analysis of overall survival according to tumor KRAS and BRAF mutation status. J. Clin. Oncol. 29(15):2011-19
-
(2011)
J. Clin. Oncol.
, vol.29
, Issue.15
, pp. 2011-2019
-
-
Van Cutsem, E.1
Kohne, C.H.2
Lang, I.3
-
16
-
-
78149250536
-
Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: The PRIME study
-
Douillard JY, Siena S, Cassidy J, et al. 2010. Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: the PRIME study. J. Clin. Oncol. 28(31):4697-705
-
(2010)
J. Clin. Oncol.
, vol.28
, Issue.31
, pp. 4697-4705
-
-
Douillard, J.Y.1
Siena, S.2
Cassidy, J.3
-
17
-
-
84903694472
-
Final results from PRIME: Randomized phase III study of panitumumab with FOLFOX4 for first-line treatment of metastatic colorectal cancer
-
Douillard JY, Siena S, Tabernero J, et al. 2014. Final results from PRIME: randomized phase III study of panitumumab with FOLFOX4 for first-line treatment of metastatic colorectal cancer. Ann. Oncol. 25:1346-55
-
(2014)
Ann. Oncol.
, vol.25
, pp. 1346-1355
-
-
Douillard, J.Y.1
Siena, S.2
Tabernero, J.3
-
18
-
-
84882937605
-
Randomized comparison of FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment of KRAS wild-Type metastatic colorectal cancer: German AIO study KRK-0306 (FIRE-3)
-
IL, May 31-June 4
-
HeinemannV, von WeikersthalLF, Decker T, et al. 2013. Randomized comparison of FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment of KRAS wild-Type metastatic colorectal cancer: German AIO study KRK-0306 (FIRE-3). Presented at Am. Soc. Clin. Onocol. Annu. Meet., Chicago, IL, May 31-June 4
-
(2013)
Presented at Am. Soc. Clin. Onocol. Annu. Meet., Chicago
-
-
Heinemann, V.1
Von Weikersthal, L.F.2
Decker, T.3
-
19
-
-
33644836082
-
Cancer and LeukemiaGroup B/SouthwestOncology Group Trial 80405: A phase III trial of chemotherapy and biologic agents for patients with untreated advanced colorectal adenocarcinoma
-
Venook AP, Blanke CD, Niedzwiecki D, et al. 2005. Cancer and LeukemiaGroup B/SouthwestOncology Group Trial 80405: a phase III trial of chemotherapy and biologic agents for patients with untreated advanced colorectal adenocarcinoma. Clin. Colorectal Cancer 5(4):292-94
-
(2005)
Clin. Colorectal Cancer
, vol.5
, Issue.4
, pp. 292-294
-
-
Venook, A.P.1
Blanke, C.D.2
Niedzwiecki, D.3
-
20
-
-
84907027361
-
CALGB/SWOG 80405: Phase III trial of irinotecan/5-FU/leucovorin (FOLFIRI) or oxaliplatin/5-FU/leucovorin (mFOLFOX6) with bevacizumab or cetuximab for patients with KRAS wild-Type untreated metastatic adenocarcinoma of the colon or rectum
-
IL, May 30-June 3
-
Venook AP, Niedzwiecki D, Lenz HJ, et al. 2014. CALGB/SWOG 80405: phase III trial of irinotecan/5-FU/leucovorin (FOLFIRI) or oxaliplatin/5-FU/leucovorin (mFOLFOX6) with bevacizumab or cetuximab for patients with KRAS wild-Type untreated metastatic adenocarcinoma of the colon or rectum. Presented at Am. Soc. Clin. Oncol. Annu. Meet., Chicago, IL, May 30-June 3
-
(2014)
Presented at Am. Soc. Clin. Oncol. Annu. Meet., Chicago
-
-
Venook, A.P.1
Niedzwiecki, D.2
Lenz, H.J.3
-
21
-
-
84871720057
-
Continuation of bevacizumab after first progression in metastatic colorectal cancer (ML18147): A randomised phase 3 trial
-
Bennouna J, Sastre J, Arnold D, et al. 2013. Continuation of bevacizumab after first progression in metastatic colorectal cancer (ML18147): a randomised phase 3 trial. Lancet Oncol. 14:29-37
-
(2013)
Lancet Oncol.
, vol.14
, pp. 29-37
-
-
Bennouna, J.1
Sastre, J.2
Arnold, D.3
-
22
-
-
84867047384
-
Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen
-
Van Cutsem E, Tabernero J, Lakomy R, et al. 2012. Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen. J. Clin. Oncol. 30:3499-506
-
(2012)
J. Clin. Oncol.
, vol.30
, pp. 3499-3506
-
-
Van Cutsem, E.1
Tabernero, J.2
Lakomy, R.3
-
23
-
-
84891831211
-
Aflibercept versus placebo in combination with fluorouracil, leucovorin and irinotecan in the treatment of previously treated metastatic colorectal cancer: Prespecified subgroup analyses from the VELOUR trial
-
Tabernero J, Van Cutsem, Lakomy R, et al. 2014. Aflibercept versus placebo in combination with fluorouracil, leucovorin and irinotecan in the treatment of previously treated metastatic colorectal cancer: prespecified subgroup analyses from the VELOUR trial. Eur. J. Cancer 50:320-31
-
(2014)
Eur. J. Cancer
, vol.50
, pp. 320-331
-
-
Tabernero, J.1
Van Cutsem Lakomy, R.2
-
24
-
-
84872921660
-
Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): An international, multicenter, randomised, placebo-controlled, phase 3 trial
-
Grothey A, Van Cutsem E, Sobrero A, et al. 2013. Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicenter, randomised, placebo-controlled, phase 3 trial. Lancet 381:303-12
-
(2013)
Lancet
, vol.381
, pp. 303-312
-
-
Grothey, A.1
Van Cutsem, E.2
Sobrero, A.3
-
25
-
-
84885792870
-
Analysis of plasma protein biomarkers from the CORRECT phase III study of regorafenib for metastatic colorectal cancer
-
IL, May 30-June 3
-
Heinz-Josef L, Van Cutsem E, Sobrero AF, et al. 2013. Analysis of plasma protein biomarkers from the CORRECT phase III study of regorafenib for metastatic colorectal cancer. Presented at Am. Soc. Clin. Oncol. Annu. Meet., Chicago, IL, May 30-June 3
-
(2013)
Presented at Am. Soc. Clin. Oncol. Annu. Meet., Chicago
-
-
Heinz-Josef, L.1
Van Cutsem, E.2
Sobrero, A.F.3
-
26
-
-
84934960339
-
Mutational analysis of biomarker samples from the CORRECT study: Correlating mutation status with clinical response to regorafenib
-
San Francisco, CA, Jan.
-
Jeffers M, Van Cutsem E, Sobrero AF, et al. 2013. Mutational analysis of biomarker samples from the CORRECT study: correlating mutation status with clinical response to regorafenib. Presented at Am. Soc. Clin. Oncol. Gastrointestinal Cancers Symp., San Francisco, CA, Jan. 24-26
-
(2013)
Presented at Am. Soc. Clin. Oncol. Gastrointestinal Cancers Symp
, pp. 24-26
-
-
Jeffers, M.1
Van Cutsem, E.2
Sobrero, A.F.3
-
27
-
-
84885366390
-
Maintenance treatment with capecitabine and bevacizumab versus observation after induction treatment with chemotherapy and bevacizumab in metastatic colorectal cancer: The phase III CAIRO3 study of the Dutch Colorectal Cancer Group
-
IL, May 30-June 3
-
Koopman M, Simkins LHJ, Tije AJT, et al. 2013. Maintenance treatment with capecitabine and bevacizumab versus observation after induction treatment with chemotherapy and bevacizumab in metastatic colorectal cancer: the phase III CAIRO3 study of the Dutch Colorectal Cancer Group. Presented at Am. Soc. Clin. Oncol. Annu. Meet., Chicago, IL, May 30-June 3
-
(2013)
Presented at Am. Soc. Clin. Oncol. Annu. Meet., Chicago
-
-
Koopman, M.1
Simkins, L.H.J.2
Tije, A.J.T.3
-
28
-
-
84904157668
-
Updated results including quality of life of the phase III CAIRO3 study of the Dutch Colorectal Cancer Group: Maintenance treatment with capecitabine and bevacizumab versus observation after induction treatment with chemotherapy and bevacizumab in metastatic colorectal cancer
-
Sep. 27-Oct. 1
-
Punt CJA, Simkens LHJ, May A, et al. 2013. Updated results including quality of life of the phase III CAIRO3 study of the Dutch Colorectal Cancer Group: maintenance treatment with capecitabine and bevacizumab versus observation after induction treatment with chemotherapy and bevacizumab in metastatic colorectal cancer. Presented at Eur. Cancer Congr., Amsterdam, Neth., Sep. 27-Oct. 1
-
(2013)
Presented at Eur. Cancer Congr., Amsterdam, Neth
-
-
Punt, C.J.A.1
Simkens, L.H.J.2
May, A.3
-
29
-
-
84875998274
-
Markers of response for the antiangiogenic agent bevacizumab
-
Lambrechts D, Lenz HJ, de Haas S, et al. 2013. Markers of response for the antiangiogenic agent bevacizumab. J. Clin. Oncol. 31(9):1219-30
-
(2013)
J. Clin. Oncol.
, vol.31
, Issue.9
, pp. 1219-1230
-
-
Lambrechts, D.1
Lenz, H.J.2
De Haas, S.3
-
30
-
-
54949085398
-
K-ras mutations and benefit from cetuximab in advanced colorectal cancer
-
Karapetis CS, Khambata-Ford S, Jonker DJ, et al. 2008. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N. Engl. J. Med. 359(17):1757-65
-
(2008)
N. Engl. J. Med.
, vol.359
, Issue.17
, pp. 1757-1765
-
-
Karapetis, C.S.1
Khambata-Ford, S.2
Jonker, D.J.3
-
31
-
-
42649145667
-
Wild-Type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
-
Amado RG, Wolf M, Peeters M, et al. 2008. Wild-Type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J. Clin. Oncol. 26(10):1626-34
-
(2008)
J. Clin. Oncol.
, vol.26
, Issue.10
, pp. 1626-1634
-
-
Amado, R.G.1
Wolf, M.2
Peeters, M.3
-
32
-
-
84883680951
-
Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer
-
Douillard JY, Oliner KS, Siena S, et al. 2013. Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer. N. Engl. J. Med. 369(11):1023-34
-
(2013)
N. Engl. J. Med.
, vol.369
, Issue.11
, pp. 1023-1034
-
-
Douillard, J.Y.1
Oliner, K.S.2
Siena, S.3
-
33
-
-
84898666033
-
Analysis of KRAS/NRAS and BRAF mutations in FIRE-3: A randomized phase III study of FOLFIRI plus cetuximab or bevacizumab as first-line treatment for wild-Type KRAS (exon 2) metastatic colorectal cancer patients
-
Stintzing S, Jung A, Rossius L, et al. 2013. Analysis of KRAS/NRAS and BRAF mutations in FIRE-3: a randomized phase III study of FOLFIRI plus cetuximab or bevacizumab as first-line treatment for wild-Type KRAS (exon 2) metastatic colorectal cancer patients. Presented at Eur. Cancer Congr., Amsterdam, Neth., Sep. 27-Oct. 1
-
(2013)
Presented at Eur. Cancer Congr., Amsterdam, Neth., Sep. 27-Oct.
, vol.1
-
-
Stintzing, S.1
Jung, A.2
Rossius, L.3
-
34
-
-
34248157118
-
Effect of aspirin on long-Term risk of colorectal cancer: Consistent evidence from randomised and observational studies
-
Flossmann E, Rothwell PM. 2007. Effect of aspirin on long-Term risk of colorectal cancer: consistent evidence from randomised and observational studies. Lancet 369(9573):1603-13
-
(2007)
Lancet
, vol.369
, Issue.9573
, pp. 1603-1613
-
-
Flossmann, E.1
Rothwell, P.M.2
-
35
-
-
78650215449
-
Long-Term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials
-
Rothwell PM, Wilson M, ElwinCE, et al. 2010. Long-Term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials. Lancet 376(9754):1741-50
-
(2010)
Lancet
, vol.376
, Issue.9754
, pp. 1741-1750
-
-
Rothwell, P.M.1
Wilson, M.2
Elwin, C.E.3
-
36
-
-
83955161674
-
Long-Term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: An analysis from the CAPP2 randomised controlled trial
-
Burn J, Gerdes AM, Macrae F, et al. 2011. Long-Term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial. Lancet 378(9809):2081-87
-
(2011)
Lancet
, vol.378
, Issue.9809
, pp. 2081-2087
-
-
Burn, J.1
Gerdes, A.M.2
MacRae, F.3
-
37
-
-
84867817838
-
Aspirin use, PIK3CA mutation, and colorectal-cancer survival
-
Liao X, Lochhead P, Nishihara R, et al. 2012. Aspirin use, PIK3CA mutation, and colorectal-cancer survival. N. Engl. J. Med. 367(17):1596-606
-
(2012)
N. Engl. J. Med.
, vol.367
, Issue.17
, pp. 1596-1606
-
-
Liao, X.1
Lochhead, P.2
Nishihara, R.3
-
38
-
-
84892843686
-
Evaluation of PIK3CA mutation as a predictor of benefit from nonsteroidal anti-inflammatory drug therapy in colorectal cancer
-
Domingo E, Church DN, Sieber O, et al. 2013. Evaluation of PIK3CA mutation as a predictor of benefit from nonsteroidal anti-inflammatory drug therapy in colorectal cancer. J. Clin. Oncol. 31(34):4297-305
-
(2013)
J. Clin. Oncol.
, vol.31
, Issue.34
, pp. 4297-4305
-
-
Domingo, E.1
Church, D.N.2
Sieber, O.3
-
39
-
-
84921406674
-
Regular aspirin use and survival in patients with PIK3CA-mutated metastatic colorectal cancer
-
Jan. 16-18
-
Kothari N, Kim RD, Gibbs P, et al. 2014. Regular aspirin use and survival in patients with PIK3CA-mutated metastatic colorectal cancer. Presented at Am. Soc. Clin.Oncol.Gastrointest. Cancers Symp., San Francisco, CA, Jan. 16-18
-
(2014)
Presented at Am. Soc. Clin.Oncol.Gastrointest. Cancers Symp., San Francisco, CA
-
-
Kothari, N.1
Kim, R.D.2
Gibbs, P.3
-
40
-
-
40549088542
-
NO-donating aspirin inhibits the activation of NF-kappaB in human cancer cell lines and Min mice
-
Williams JL, Ji P, Ouyang N, et al. 2008. NO-donating aspirin inhibits the activation of NF-kappaB in human cancer cell lines and Min mice. Carcinogenesis 29:390-97
-
(2008)
Carcinogenesis
, vol.29
, pp. 390-397
-
-
Williams, J.L.1
Ji, P.2
Ouyang, N.3
-
41
-
-
33750223793
-
Effect of aspirin on the Wnt/beta-catenin pathway is mediated via protein phosphatase 2A
-
Bos CL, Kodach LL, van den Brink GR, et al. 2006. Effect of aspirin on the Wnt/beta-catenin pathway is mediated via protein phosphatase 2A. Oncogene 25:6447-56
-
(2006)
Oncogene
, vol.25
, pp. 6447-6456
-
-
Bos, C.L.1
Kodach, L.L.2
Van Den Brink, G.R.3
-
42
-
-
84861648941
-
Aspirin inhibits mTOR signaling, activates AMP-Activated protein kinase, and induces autophagy in colorectal cancer cells
-
Din FV, Valanciute A, Houde VP, et al. 2012. Aspirin inhibits mTOR signaling, activates AMP-Activated protein kinase, and induces autophagy in colorectal cancer cells. Gastroenterology 142:1504.e3-1515.e3
-
(2012)
Gastroenterology
, vol.142
, pp. 1504e3-1515e3
-
-
Din, F.V.1
Valanciute, A.2
Houde, V.P.3
-
43
-
-
3042562279
-
From the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors
-
Zhu J, Huang JW, Tseng PH, et al. 2004. From the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors. Cancer Res. 64:4309-18
-
(2004)
Cancer Res.
, vol.64
, pp. 4309-4318
-
-
Zhu, J.1
Huang, J.W.2
Tseng, P.H.3
-
44
-
-
84879395305
-
Aspirin use and risk of colorectal cancer according to BRAF mutation status
-
Nishihara R, Lochhead P, Kuchiba A, et al. 2013. Aspirin use and risk of colorectal cancer according to BRAF mutation status. JAMA 309(24):2563-71
-
(2013)
JAMA
, vol.309
, Issue.24
, pp. 2563-2571
-
-
Nishihara, R.1
Lochhead, P.2
Kuchiba, A.3
-
45
-
-
84897978063
-
Expression of HLA class i antigen, aspirin use and survival after a diagnosis of colon cancer
-
Reimers MS, Bastiaannet E, Langley RE, et al. 2014. Expression of HLA class I antigen, aspirin use and survival after a diagnosis of colon cancer. JAMA Intern. Med. 174(5):732-39
-
(2014)
JAMA Intern. Med.
, vol.174
, Issue.5
, pp. 732-739
-
-
Reimers, M.S.1
Bastiaannet, E.2
Langley, R.E.3
-
46
-
-
84899547782
-
Aspirin and the risk of colorectal cancer in relation to the expression of 15-hydroxyprostaglandin dehydrogenase
-
233re2
-
Fink SP, YamauchiM, Nishihara R, et al. 2014. Aspirin and the risk of colorectal cancer in relation to the expression of 15-hydroxyprostaglandin dehydrogenase. Sci. Transl. Med. 6:233re2
-
(2014)
Sci. Transl. Med.
, vol.6
-
-
Fink, S.P.1
Yamauchi, M.2
Nishihara, R.3
-
48
-
-
84879777241
-
Nivolumab plus ipilimumab in advanced melanoma
-
Wolchok JD, Kluger H, Callahan MK, et al. 2013. Nivolumab plus ipilimumab in advanced melanoma. N. Engl. J. Med. 369(2):122-33
-
(2013)
N. Engl. J. Med.
, vol.369
, Issue.2
, pp. 122-133
-
-
Wolchok, J.D.1
Kluger, H.2
Callahan, M.K.3
-
49
-
-
77954899030
-
Phase i study of single-Agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: Safety, clinical activity, pharmacodynamics, and immunologic correlates
-
Brahmer JR, Drake CG, Wollner I, et al. 2010. Phase I study of single-Agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J. Clin. Oncol. 28(19):3167-75
-
(2010)
J. Clin. Oncol.
, vol.28
, Issue.19
, pp. 3167-3175
-
-
Brahmer, J.R.1
Drake, C.G.2
Wollner, I.3
-
50
-
-
84872514622
-
Durable cancer regression off-Treatment and effective reinduction therapy with an anti-PD-1 antibody
-
Lipson EJ, SharfmanWH, Drake CG, et al. 2013. Durable cancer regression off-Treatment and effective reinduction therapy with an anti-PD-1 antibody. Clin. Cancer Res. 19:462-68
-
(2013)
Clin. Cancer Res.
, vol.19
, pp. 462-468
-
-
Lipson, E.J.1
Sharfman, W.H.2
Drake, C.G.3
-
51
-
-
0035875903
-
Tumor-infiltrating lymphocytes are amarker for microsatellite instability in colorectal carcinoma
-
Smyrk TC, Watson P, Kaul K, et al. 2001. Tumor-infiltrating lymphocytes are amarker for microsatellite instability in colorectal carcinoma. Cancer 91:2417-22
-
(2001)
Cancer
, vol.91
, pp. 2417-2422
-
-
Smyrk, T.C.1
Watson, P.2
Kaul, K.3
-
53
-
-
84922675130
-
A dose-escalation phase i study of a first-in-class cancer stemness inhibitor in patients with advanced malignancies
-
IL, May 30-June 3
-
Langleben A, Supko JG, Hotte SJ, et al. 2013. A dose-escalation phase I study of a first-in-class cancer stemness inhibitor in patients with advanced malignancies. Presented at Am. Soc. Clin. Oncol. Annu. Meet., Chicago, IL, May 30-June 3
-
(2013)
Presented at Am. Soc. Clin. Oncol. Annu. Meet., Chicago
-
-
Langleben, A.1
Supko, J.G.2
Hotte, S.J.3
-
54
-
-
77955277111
-
Effects of KRAS, BRAF, NRAS, and PIK3CAmutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: A retrospective consortium analysis
-
De RoockW, Claes B, BernasconiD, et al. 2010. Effects of KRAS, BRAF, NRAS, and PIK3CAmutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. Lancet Oncol. 11:753-62
-
(2010)
Lancet Oncol.
, vol.11
, pp. 753-762
-
-
De Roock, W.1
Claes, B.2
Bernasconi, D.3
-
55
-
-
77955266489
-
Cetuximab plus FOLFIRI in the treatment of metastatic colorectal cancer (mCRC): The influence of KRAS and BRAF biomarkers on outcome: Updated data from the CRYSTAL trial
-
Jan. 22-24
-
Van Cutsem E, Lang I, Folprecht G, et al. 2010. Cetuximab plus FOLFIRI in the treatment of metastatic colorectal cancer (mCRC): the influence of KRAS and BRAF biomarkers on outcome: updated data from the CRYSTAL trial. Presented at Am. Soc. Clin. Oncol. Gastrointest. Cancers Symp., Orlando, FL, Jan. 22-24
-
(2010)
Presented at Am. Soc. Clin. Oncol. Gastrointest. Cancers Symp., Orlando, FL
-
-
Van Cutsem, E.1
Lang, I.2
Folprecht, G.3
-
56
-
-
84863230465
-
Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR
-
Prahallad A, Sun C, Huang S, et al. 2012. Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. Nature 483:100-3
-
(2012)
Nature
, vol.483
, pp. 100-103
-
-
Prahallad, A.1
Sun, C.2
Huang, S.3
-
57
-
-
84873360893
-
Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with PI3K inhibition or demethylating agents
-
MaoM, Tian F, Mariadason JM, et al. 2013. Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with PI3K inhibition or demethylating agents. Clin. Cancer Res. 19:657-67
-
(2013)
Clin. Cancer Res.
, vol.19
, pp. 657-667
-
-
Mao, M.1
Tian, F.2
Mariadason, J.M.3
-
58
-
-
84878066430
-
Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer
-
Coffee EM, Faber AC, Roper J, et al. 2013. Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer. Clin. Cancer Res. 19:2688-98
-
(2013)
Clin. Cancer Res.
, vol.19
, pp. 2688-2698
-
-
Coffee, E.M.1
Faber, A.C.2
Roper, J.3
-
59
-
-
0032515141
-
Reovirus therapy of tumors with activated Ras pathway
-
Coffey MC, Strong JE, Forsyth PA, et al. 1998. Reovirus therapy of tumors with activated Ras pathway. Science 282(5392):1332-34
-
(1998)
Science
, vol.282
, Issue.5392
, pp. 1332-1334
-
-
Coffey, M.C.1
Strong, J.E.2
Forsyth, P.A.3
-
60
-
-
0023267665
-
Reovirus type 3 infection in patients with primary biliary cirrhosis and primary sclerosing cholangitis
-
Minuk GY, Rascanin N, Paul RW, et al. 1987. Reovirus type 3 infection in patients with primary biliary cirrhosis and primary sclerosing cholangitis. J. Hepatol. 5(1):8-13
-
(1987)
J. Hepatol.
, vol.5
, Issue.1
, pp. 8-13
-
-
Minuk, G.Y.1
Rascanin, N.2
Paul, R.W.3
-
61
-
-
77956060455
-
Intravenous administration of ReolysinR-, a live replication competent RNA virus is safe in patients with advanced solid tumors
-
Gollamudi R, Ghalib MH, Desai KK, et al. 2010. Intravenous administration of ReolysinR-, a live replication competent RNA virus is safe in patients with advanced solid tumors. Invest. New. Drugs 28:641-49
-
(2010)
Invest. New. Drugs
, vol.28
, pp. 641-649
-
-
Gollamudi, R.1
Ghalib, M.H.2
Desai, K.K.3
|