Mortalin/GRP75 binds to complement C9 and plays a role in resistance to complement-dependent cytotoxicity

Journal of Biological Chemistry

Volumn 289, Issue 21, 2014, Pages 15014-15022

  Ray, Moran Saar ^a   Moskovich, Oren ^a   Iosefson, Ohad ^a   Fishelson, Zvi ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DEATH; CELL MEMBRANES;

ATPASE DOMAIN; AUTOIMMUNE DISEASE; CANCER IMMUNOTHERAPY; COMPLEMENT-DEPENDENT CYTOTOXICITIES; TARGET CELLS; THERAPEUTIC TARGETS;

DEPOSITION;

COMPLEMENT COMPONENT C8; COMPLEMENT COMPONENT C9; COMPLEMENT MEMBRANE ATTACK COMPLEX; HEAT SHOCK PROTEIN 70; MITOCHONDRIAL PROTEIN; MORTALIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; COMPLEMENT ACTIVATION; COMPLEMENT DEPENDENT CYTOTOXICITY; CONTROLLED STUDY; CYTOPLASM; ERYTHROLEUKEMIA CELL; HUMAN; HUMAN CELL; MITOCHONDRIAL TARGETING SIGNAL; NONHUMAN; NORMAL HUMAN; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN STABILITY; PROTEIN SYNTHESIS; PROTEIN TARGETING;

C5B-9; COMPLEMENT SYSTEM; GRP75; HEAT SHOCK PROTEIN; IMMUNOLOGY; MOLECULAR CHAPERONE; MORTALIN; NECROSIS (NECROTIC DEATH);

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; BINDING SITES; BLOTTING, WESTERN; COMPLEMENT C9; COMPLEMENT MEMBRANE ATTACK COMPLEX; COMPLEMENT SYSTEM PROTEINS; CYTOTOXICITY, IMMUNOLOGIC; GREEN FLUORESCENT PROTEINS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; K562 CELLS; MICROSCOPY, CONFOCAL; PROTEIN BINDING; RNA INTERFERENCE; SODIUM CHLORIDE;

EID: 84901424236     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.552406     Document Type: Article

References (29)

1. Müller-Eberhard, H. J. (1986) The membrane attack complex of complement. Annu. Rev. Immunol. 4, 503-528
2. Morris, J. C., and Waldmann, T. A. (2009) Antibody-based therapy of leukaemia. Expert Rev. Mol. Med. 11, e29
3. Walport, M. J. (2001) Complement: first of two parts. N. Engl. J. Med. 344, 1058-1066
4. Gancz, D., and Fishelson, Z. (2009) Cancer resistance to complement-dependent cytotoxicity (CDC): problem-oriented research and development. Mol. Immunol. 46, 2794-2800
5. Carney, D. F., Koski, C. L., and Shin, M. L. (1985) Elimination of terminal complement intermediates from the plasma membrane of nucleated cells: the rate of disappearance differs for cells carrying C5b-7 or C5b-8 or a mixture of C5b-8 with a limited number of C5b-9. J. Immunol. 134, 1804-1809 (Pubitemid 15130308)
6. Scolding, N. J., Morgan, B. P., Houston, W. A., Linington, C., Campbell, A. K., and Compston, D. A. (1989) Vesicular removal by oligodendrocytes of membrane attack complexes formed by activated complement. Nature 339, 620-622
7. Morgan, B. P., Dankert, J. R., and Esser, A. F. (1987) Recovery of human neutrophils from complement attack: removal of the membrane attack complex by endocytosis and exocytosis. J. Immunol. 138, 246-253 (Pubitemid 17218426)
8. Stein, J. M., and Luzio, J. P. (1991) Ectocytosis caused by sublytic autologous complement attack on human neutrophils: the sorting of endogenous plasma-membrane proteins and lipids into shed vesicles. Biochem. J. 274, 381-386
9. Moskovich, O., and Fishelson, Z. (2007) Live cell imaging of outward and inward vesiculation induced by the complement C5b-9 complex. J. Biol. Chem. 282, 29977-29986 (Pubitemid 350035280)
10. Moskovich, O., Herzog, L. O., Ehrlich, M., and Fishelson, Z. (2012) Caveolin- 1 and dynamin-2 are essential for removal of the complement C5b-9 complex via endocytosis. J. Biol. Chem. 287, 19904-19915
11. Bhattacharyya, T., Karnezis, A. N., Murphy, S. P., Hoang, T., Freeman, B. C., Phillips, B., and Morimoto, R. I. (1995) Cloning and subcellular localization of human mitochondrial Hsp70. J. Biol. Chem. 270, 1705-1710
12. Koehler, C. M. (2004) New developments in mitochondrial assembly. Annu. Rev. Cell Dev. Biol. 20, 309-335 (Pubitemid 39488641)
13. Wiedemann, N., Frazier, A. E., and Pfanner, N. (2004) The protein import machinery of mitochondria. J. Biol. Chem. 279, 14473-14476 (Pubitemid 38618831)
14. Liu, Y., Liu, W., Song, X. D., and Zuo, J. (2005) Effect of GRP75/mtHsp70/ PBP74/mortalin overexpression on intracellular ATP level, mitochondrial membrane potential and ROS accumulation following glucose deprivation in PC12 cells. Mol. Cell. Biochem. 268, 45-51 (Pubitemid 40287825)
15. +]i ratio in cultured vascular smooth muscle cells. Circ. Res. 91, 915-922 (Pubitemid 35373591)
16. Wadhwa, R., Takano, S., Taira, K., and Kaul, S. C. (2004) Reduction in mortalin level by its antisense expression causes senescence-like growth arrest in human immortalized cells. J. Gene Med. 6, 439-444 (Pubitemid 40228060)
17. Dundas, S. R, Lawrie, L. C., Rooney, P. H., and Murray, G. I. (2005) Mortalin is overexpressed by colorectal adenocarcinomas and correlates with poor survival. J. Pathol. 205, 74-81 (Pubitemid 40029095)
18. Wadhwa, R., Takano, S., Kaur, K., Deocaris, C. C., Pereira-Smith, O. M., Reddel, R. R., and Kaul, S. C. (2006) Up-regulation of mortalin/mtHsp70/ Grp75 contributes to human carcinogenesis. Int. J. Cancer 118, 2973-2980
19. Pilzer, D., and Fishelson, Z. (2005) Mortalin/GRP75 promotes release of membrane vesicles from immune attacked cells and protection from complement- mediated lysis. Int. Immunol. 17, 1239-1248 (Pubitemid 41236079)
20. Pilzer, D., Saar, M., Koya, K., and Fishelson, Z. (2010) Mortalin inhibitors sensitize K562 leukemia cells to complement-dependent cytotoxicity. Int. J. Cancer 126, 1428-1435
21. Deocaris, C. C., Kaul, S. C., and Wadhwa, R. (2006) On the brotherhood of the mitochondrial chaperones mortalin and heat shock protein 60. Cell Stress Chaperones 11, 116-128 (Pubitemid 43948351)
22. Reiter, Y., Ciobotariu, A., and Fishelson, Z. (1992) Sublytic complement attack protects tumor cells from lytic doses of antibody and complement. Eur. J. Immunol. 22, 1207-1213
23. Iosefson, O., and Azem, A. (2010) Reconstitution of the mitochondrial Hsp70 (mortalin)-p53 interaction using purified proteins: identification of additional interacting regions. FEBS Lett. 584, 1080-1084
24. Tschopp, J. (1984) Circular polymerization of the membranolytic ninth component of complement: dependence on metal ions. J. Biol. Chem. 259, 10569-10573 (Pubitemid 14064159)
25. Ziporen, L., Donin, N., Shmushkovich, T., Gross, A., and Fishelson, Z. (2009) Programmed necrotic cell death induced by complement involves a Bid-dependent pathway. J. Immunol. 182, 515-521
26. Fishelson, Z., Attali, G., and Mevorach, D. (2001) Complement and apoptosis. Mol. Immunol. 38, 207-219 (Pubitemid 32786778)
27. Morgan, B. P. (1989) Complement membrane attack on nucleated cells: resistance, recovery and nonlethal effects. Biochem. J. 264, 1-14 (Pubitemid 19283496)
28. Tegla, C. A., Cudrici, C., Patel, S., Trippe, R., 3rd, Rus, V., Niculescu, F., and Rus, H. (2011) Membrane attack by complement: the assembly and biology of terminal complement complexes. Immunol. Res. 51, 45-60
29. Sriram, M., Osipiuk, J., Freeman, B., Morimoto, R., and Joachimiak, A. (1997) Human Hsp70 molecular chaperone binds two calcium ions within the ATPase domain. Structure 5, 403-414 (Pubitemid 27169941)