Mortalin-p53 interaction in cancer cells is stress dependent and constitutes a selective target for cancer therapy

Cell Death and Differentiation

Volumn 18, Issue 6, 2011, Pages 1046-1056

  Lu, W J ^a   Lee, N P ^a   Kaul, S C ^b   Lan, F ^c   Poon, R T P ^a   Wadhwa, R ^b   Luk, J M ^a,d,e  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d NATIONAL UNIVERSITY HEALTH SYSTEM   (Singapore)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

cancer; mortalin p53 interaction; stress; target; therapy

Indexed keywords

1 ETHYL 2 [[3 ETHYL 5 (3 METHYLBENZOTHIAZOLIN 2 YLIDENE) 4 OXOTHIAZOLIDIN 2 YLIDENE]METHYL]PYRIDINIUM CHLORIDE; CISPLATIN; DOXORUBICIN; HEAT SHOCK PROTEIN 70; PROTEIN MORTALIN; PROTEIN P53; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER THERAPY; CELL SPECIFICITY; CELL STRAIN HEPG2; CELL STRESS; CONTROLLED STUDY; GENE MUTATION; HUMAN; HUMAN CELL; LIVER CELL; LIVER CELL CARCINOMA; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING;

APOPTOSIS; CARCINOMA, HEPATOCELLULAR; HEP G2 CELLS; HEPATOCYTES; HSP70 HEAT-SHOCK PROTEINS; HUMANS; MUTATION; PEPTIDES; STRESS, PHYSIOLOGICAL; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53;

EID: 79955827220     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2010.177     Document Type: Article

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