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Volumn 3, Issue 8, 2002, Pages 555-565

The protein import motor of mitochondria

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; HEAT SHOCK PROTEIN;

EID: 0036343904     PISSN: 14710072     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrm878     Document Type: Review
Times cited : (305)

References (111)
  • 6
    • 0034664243 scopus 로고    scopus 로고
    • The ER translocon and retrotranslocation: Is the shift into reverse manual or automatic?
    • (2000) Cell , vol.102 , pp. 709-712
    • Johnson, A.E.1    Haigh, N.G.2
  • 16
    • 0029070886 scopus 로고
    • The MIM complex mediates preprotein translocation across the mitochondrial inner membrane and couples it to the mt-Hsp70/ATP driving system
    • (1995) Cell , vol.81 , pp. 1086-1093
    • Berthold, J.1
  • 20
    • 0032568029 scopus 로고    scopus 로고
    • Carrier protein import into mitochondria mediated by the intermembrane proteins Tim10/Mrs11 and Tim12/Mrs5
    • (1998) Nature , vol.391 , pp. 912-915
    • Sirrenberg, C.1
  • 23
    • 0032536045 scopus 로고    scopus 로고
    • Import of mitochondrial carriers mediated by essential proteins of the intermembrane space
    • (1998) Science , vol.279 , pp. 369-373
    • Koehler, C.M.1
  • 24
    • 0033978123 scopus 로고    scopus 로고
    • Tim18p, a new subunit of the TIM22 complex that mediates insertion of imported proteins into the yeast mitochondrial inner membrane
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 1187-1193
    • Koehler, C.M.1
  • 25
    • 0034387981 scopus 로고    scopus 로고
    • The role of the TIM8-13 complex in the import of Tim23 into mitochondria
    • (2000) EMBO J. , vol.19 , pp. 6392-6400
    • Paschen, S.A.1
  • 26
    • 0036187429 scopus 로고    scopus 로고
    • Tim22, the essential core of the mitochondrial protein insertion complex, forms a voltage-activated and signal-gated channel
    • (2002) Mol. Cell , vol.9 , pp. 363-373
    • Kovermann, P.1
  • 28
    • 0028796617 scopus 로고
    • Mitochondrial protein import: Reversible binding of the presequence at the trans side of the outer membrane drives partial translocation and unfolding
    • (1995) Cell , vol.80 , pp. 27-37
    • Mayer, A.1    Neupert, W.2    Lill, R.3
  • 29
    • 0032188847 scopus 로고    scopus 로고
    • Tom40 forms the hydrophilic channel of the mitochondrial import pore for preproteins
    • (1998) Nature , vol.395 , pp. 516-521
    • Hill, K.1
  • 30
    • 0034665038 scopus 로고    scopus 로고
    • Recognition of preproteins by the isolated TOM complex of mitochondria
    • (2000) EMBO J. , vol.19 , pp. 4895-4902
    • Stan, T.1
  • 31
    • 0035844870 scopus 로고    scopus 로고
    • Tom40, the pore-forming component of the protein-conducting TOM channel in the outer membrane of mitochondria
    • (2001) J. Cell Biol. , vol.153 , pp. 1151-1160
    • Ahting, U.1
  • 32
    • 0036306343 scopus 로고    scopus 로고
    • Protein translocase of the outer mitochondrial membrane: Role of import receptors in the structural organization of the TOM complex
    • (2002) J. Mol. Biol. , vol.316 , pp. 657-666
    • Model, K.1
  • 34
    • 0033616726 scopus 로고    scopus 로고
    • Uncoupling of transfer of the presequence and unfolding of the mature domain in precursor translocation across the mitochondrial outer membrane
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 3634-3639
    • Kanamori, T.1
  • 36
    • 0034640088 scopus 로고    scopus 로고
    • Tim23 links the inner and outer mitochondrial membranes
    • (2000) Cell , vol.101 , pp. 401-412
    • Donzeau, M.1
  • 37
    • 0035190910 scopus 로고    scopus 로고
    • A presequence- and voltage-sensitive channel of the mitochondrial preprotein translocase formed by Tim23
    • (2001) Nature Struct. Biol. , vol.8 , pp. 1074-1082
    • Truscott, K.N.1
  • 39
    • 0032511189 scopus 로고    scopus 로고
    • The preprotain translocation channel of the outer membrane of mitochondria
    • (1998) Cell , vol.93 , pp. 1009-1019
    • Künkele, K.P.1
  • 50
    • 0028132179 scopus 로고
    • Mitochondrial Hsp70/MIM44 complex facilitates protein import
    • (1994) Nature , vol.371 , pp. 768-774
    • Schneider, H.-C.1
  • 51
    • 0024309756 scopus 로고
    • SSC1, an essential member of the yeast HSP70 multigene family, encodes a mitochondrial protein
    • (1989) Mol. Cell. Biol. , vol.9 , pp. 3003-3008
    • Craig, E.A.1
  • 52
    • 0025039149 scopus 로고
    • Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins
    • (1990) Nature , vol.348 , pp. 137-143
    • Kang, R.-J.1
  • 53
    • 0028046847 scopus 로고
    • Mitochondrial protein import: Biochemical and genetic evidence for interaction of matrix hsp70 and the inner membrane protein MIM44
    • (1994) J. Cell Biol. , vol.127 , pp. 1547-1556
    • Rassow, J.1
  • 54
    • 0028556615 scopus 로고
    • Dynamic interaction between lsp45 and mitochondrial hsp70 in the protein import system of the yeast mitochondrial inner membrane
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 12818-12822
    • Kronidou, N.G.1
  • 55
    • 0038889171 scopus 로고    scopus 로고
    • Separation of structural and dynamic functions of the mitochondrial translocase: Tim44 is crucial for the inner membrane import sites in translocation of tightly folded domains, but not of loosely folded preproteins
    • (1998) EMBO J. , vol.17 , pp. 4226-4237
    • Bömar, U.1
  • 67
    • 0028215225 scopus 로고
    • A mitochondrial homolog of bacterial GrpE interacts with mitochondrial hsp70 and is essential for viabilitity
    • (1994) EMBO J. , vol.13 , pp. 1998-2006
    • Bolliger, L.1
  • 74
    • 0028834046 scopus 로고
    • Can Hsp70 proteins act as force-generating motors?
    • (1995) Cell , vol.80 , pp. 11-14
    • Glick, B.S.1
  • 76
    • 4244200516 scopus 로고    scopus 로고
    • Unfolding of preproteins by the mitochondrial import motor: Evidence for a molecular ratchet mechanism
    • (2002) EMBO J. , vol.21 , pp. 3653-3671
    • Okamoto, K.1
  • 83
    • 0029992278 scopus 로고    scopus 로고
    • Molecular chaperones in cellular folding
    • (1996) Nature , vol.381 , pp. 571-579
    • Hartl, F.U.1
  • 85
    • 0030845840 scopus 로고    scopus 로고
    • The Tim core complex defines the number of mitochondrial translocation contact sites and can hold arrested preproteins in the absence of matrix Hsp70-Tim44
    • (1997) EMBO J. , vol.16 , pp. 5408-5419
    • Dekker, P.J.1
  • 88
    • 0022515029 scopus 로고
    • Binding of a specific ligand inhibits import of a purified precursor protein into mitochondria
    • (1986) Nature , vol.322 , pp. 228-232
    • Eilers, M.1    Schatz, G.2
  • 89
    • 0024454311 scopus 로고
    • Translocation arrest by reversible folding of a precursor protein imported into mitochondria A means to quantitate translocation contact sites
    • (1989) J. Cell Biol. , vol.109 , pp. 1421-1428
    • Rassow, J.1
  • 90
    • 0032538892 scopus 로고    scopus 로고
    • Unfolding of preproteins upon import into mitochondria
    • (1998) EMBO J. , vol.17 , pp. 6497-6507
    • Gaume, B.1
  • 92
    • 0028963263 scopus 로고
    • Mitochondrial import of subunit Va of cytochrome c oxidase characterized with yeast mutants
    • (1995) J. Biol. Chem. , vol.270 , pp. 3788-3796
    • Gartner, P.1
  • 93
    • 0037013962 scopus 로고    scopus 로고
    • The Hsp70 peptide-binding domain determines the interaction of the ATPase domain with Tim44 in mitochondria
    • (2002) EMBO J. , vol.21 , pp. 2626-2635
    • Strub, A.1    Rottgers, K.2    Voos, W.3
  • 94
    • 0033612301 scopus 로고    scopus 로고
    • The protein import motor of mitochondria: Unfolding and trapping of preproteins are distinct and separable functions of matrix Hsp70
    • (1999) Cell , vol.97 , pp. 565-574
    • Voisine, C.1
  • 96
    • 0033620691 scopus 로고    scopus 로고
    • The J-related segment of Tim44 is essential for cell viability: A mutant Tim44 remains in the mitochondrial import site, but inefficiently recruits mtHsp70 and impairs protein translocation
    • (1999) J. Cell Biol. , vol.145 , pp. 961-972
    • Merlin, A.1
  • 100
    • 0023987428 scopus 로고
    • Point mutations destabilizing a precursor protein enhance its post-translational import into mitochondria
    • (1988) EMBO J. , vol.7 , pp. 1147-1151
    • Vestweber, D.1    Schatz, G.2
  • 101
    • 0027490849 scopus 로고
    • A dual role for mitochondrial heat shock protein 70 in membrane translocation of preproteins
    • (1993) J. Cell Biol. , vol.123 , pp. 109-117
    • Gambill, B.D.1
  • 102
    • 0029934520 scopus 로고    scopus 로고
    • Differential requirement for the mitochondrial Hsp70-Tim44 complex in unfolding and translocation of preproteins
    • (1996) EMBO J. , vol.15 , pp. 2668-2677
    • Voos, W.1
  • 104
    • 0030781431 scopus 로고    scopus 로고
    • Active unfolding of precursor proteins during mitochondrial protein import
    • (1997) EMBO J. , vol.16 , pp. 6727-6736
    • Matouschek, A.1
  • 106
    • 0033523904 scopus 로고    scopus 로고
    • Mechanical unfolding intermediates in titin modules
    • (1999) Nature , vol.402 , pp. 100-103
    • Marszalek, P.E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.