Hot spot-based design of small-molecule inhibitors for protein-protein interactions

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 11, 2014, Pages 2546-2554

  Guo, Wenxing ^a   Wisniewski, John A ^a   Ji, Haitao ^a  

^a UNIVERSITY OF UTAH   (United States)

Author keywords

Hot spots; Inhibitor; Protein protein interactions; Rational design; Selectivity

Indexed keywords

ALANINE; ALPHA INTERFERON; CADHERIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PROTEIN BCL XL; PROTEIN P53; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; VON HIPPEL LINDAU PROTEIN; MOLECULAR LIBRARY; PROTEIN; PROTEIN BINDING;

ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; ENERGY; FLUORESCENCE CORRELATION SPECTROSCOPY; MOLECULAR DYNAMICS; PHYSICAL CHEMISTRY; PROTEIN PROTEIN INTERACTION; SURFACE PLASMON RESONANCE; X RAY CRYSTALLOGRAPHY; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DESIGN; DRUG EFFECTS; MOLECULAR LIBRARY; PHARMACOLOGY; SYNTHESIS;

DRUG DESIGN; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; PROTEINS; SMALL MOLECULE LIBRARIES;

EID: 84899964275     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.03.095     Document Type: Review

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