Overexpression of Mortalin in hepatocellular carcinoma and its relationship with angiogenesis and epithelial to mesenchymal transition

International Journal of Oncology

Volumn 44, Issue 1, 2014, Pages 247-255

  Chen, Jing ^a   Liu, Wen Bin ^a   Jia, Wei Dong ^a   Xu, Ge Liang ^a   Ma, Jin Liang ^a   Huang, Mei ^a   Deng, Yan Ru ^a   Li, Jian Sheng ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

Angiogenesis; Epithelial mesenchymal transition; Hepatocellular carcinoma; Mortalin; Vimentin

Indexed keywords

HEAT SHOCK PROTEIN; MORTALIN; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; VIMENTIN;

ADULT; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER SIZE; CANCER STAGING; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; METASTASIS POTENTIAL; MIDDLE AGED; NEOVASCULARIZATION (PATHOLOGY); PRIORITY JOURNAL;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HSP70 HEAT-SHOCK PROTEINS; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM STAGING; NEOVASCULARIZATION, PATHOLOGIC; TUMOR MARKERS, BIOLOGICAL;

EID: 84891904072     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2013.2161     Document Type: Article

References (27)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin 61: 69-90, 2011.
2. Forner A, Llovet JM and Bruix J: Hepatocellular carcinoma. Lancet 379: 1245-1255, 2012.
3. Polyak K and Weinberg RA: Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer 9: 265-273, 2009.
4. Christiansen JJ and Rajasekaran AK: Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis. Cancer Res 66: 8319-8326, 2006.
5. Tanaka S and Arii S: Molecular targeted therapies in hepatocellular carcinoma. Semin Oncol 39: 486-492, 2012.
6. Wadhwa R, Taira K and Kaul SC: An Hsp70 family chaperone, mortalin/mthsp70/PBP74/Grp75: what, when, and where? Cell Stress Chaperones 7: 309-316, 2002.
7. Wadhwa R, Takano S, Kaur K, et al: Upregulation of mortalin/mthsp70/Grp75 contributes to human carcinogenesis. Int J Cancer 118: 2973-2980, 2006.
8. Mizukoshi E, Suzuki M, Misono T, et al: Cell-cycle dependent tyrosine phosphorylation on mortalin regulates its interaction with fibroblast growth factor-1. Biochem Biophys Res Commun 280: 1203-1209, 2001.
9. Wadhwa R, Takano S, Robert M, et al: Inactivation of tumor suppressor p53 by mot-2, a hsp70 family member. J Biol Chem 273: 29586-29591, 1998.
10. Wadhwa R, Yaguchi T, Hasan MK, Taira K and Kaul SC: Mortalin-MPD (mevalonate pyrophosphate decarboxylase) interactions and their role in control of cellular proliferation. Biochem Biophys Res Commun 302: 735-742, 2003.
11. Yi X, Luk JM, Lee NP, et al: Association of mortalin (HSPA9) with liver cancer metastasis and prediction for early tumor recurrence. Mol Cell Proteomics 7: 315-325, 2008.
12. Li Y, Tang Y, Ye L, et al: Establishment of a hepatocellular carcinoma cell line with unique metastatic characteristics through in vivo selection and screening for metastasis-related genes through cDNA microarray. J Cancer Res Clin Oncol 129: 43-51, 2003.
13. Li Y, Tang ZY, Ye SL, et al: Establishment of cell clones with different metastatic potential from the metastatic hepatocellular carcinoma cell line MHCC97. World J Gastroenterol 7: 630-636, 2001.
14. Edmondson HA and Steiner PE: Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. Cancer 7: 462-503, 1954.
15. Chen MH, Yip GW, Tse GM, et al: Expression of basal keratins and vimentin in breast cancers of young women correlates with adverse pathologic parameters. Mod Pathol 21: 1183-1191, 2008.
16. Weidner N, Semple JP, Welch WR and Folkman J: Tumor angiogenesis and metastasis - correlation in invasive breast carcinoma. N Engl J Med 324: 1-8, 1991.
17. Thiery JP: Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2: 442-454, 2002.
18. Hartl FU: Molecular chaperones in cellular protein folding. Nature 381: 571-579, 1996.
19. Calderwood SK, Khaleque MA, Sawyer DB and Ciocca DR: Heat shock proteins in cancer: chaperones of tumorigenesis. Trends Biochem Sci 31: 164-172, 2006.
20. Ma Z, Izumi H, Kanai M, Kabuyama Y, Ahn NG and Fukasawa K: Mortalin controls centrosome duplication via modulating centrosomal localization of p53. Oncogene 25: 5377-5390, 2006.
21. Lu WJ, Lee NP, Kaul SC, et al: Mortalin-p53 interaction in cancer cells is stress dependent and constitutes a selective target for cancer therapy. Cell Death Differ 18: 1046-1056, 2011.
22. Dundas SR, Lawrie LC, Rooney PH and Murray GI: Mortalin is over-expressed by colorectal adenocarcinomas and correlates with poor survival. J Pathol 205: 74-81, 2005.
23. Chen X, Xu B, Li H, et al: Expression of mortalin detected in human liver cancer by tissue microarrays. Anat Rec 294: 1344-1351, 2011.
24. Kimura H, Nakajima T, Kagawa K, et al: Angiogenesis in hepatocellular carcinoma as evaluated by CD34 immunohistochemistry. Liver 18: 14-19, 1998.
25. Gupta GP and Massague J: Cancer metastasis: building a framework. Cell 127: 679-695, 2006.
26. Zhou Y, Mao H, Li S, et al: HSP72 inhibits Smad3 activation and nuclear translocation in renal epithelial-to-mesenchymal transition. J Am Soc Nephrol 21: 598-609, 2010.
27. Li Y, Kang X and Wang Q: HSP70 decreases receptor-dependent phosphorylation of Smad2 and blocks TGF-beta-induced epithelial-mesenchymal transition. J Genet Genomics 38: 111-116, 2011.