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Volumn 423, Issue 2, 2012, Pages 411-416

Cytoplasmic sequestration of the tumor suppressor p53 by a heat shock protein 70 family member, mortalin, in human colorectal adenocarcinoma cell lines

Author keywords

Colorectal adenocarcinoma; Heat shock proteins; Mortalin; Non mutational inactivation; Tumor suppressor

Indexed keywords

HEAT SHOCK PROTEIN 70; MONOCLONAL ANTIBODY; NUCLEAR PROTEIN; PROTEIN MORTALIN; PROTEIN P53; UNCLASSIFIED DRUG;

EID: 84862905166     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.05.139     Document Type: Article
Times cited : (39)

References (45)
  • 1
    • 0030000199 scopus 로고    scopus 로고
    • Prognostic significance of cytoplasmic p53 overexpression in colorectal cancer A immunohistochemical analysis.
    • Flamini G., Curigliano G., Ratto C., et al. Prognostic significance of cytoplasmic p53 overexpression in colorectal cancer A immunohistochemical analysis. Eur. J Can 1996, 32:802-806.
    • (1996) Eur. J Can , vol.32 , pp. 802-806
    • Flamini, G.1    Curigliano, G.2    Ratto, C.3
  • 2
    • 0028286988 scopus 로고
    • An independent prognostic indicator in colorectal adenocarcinomas
    • Bosari S., Viale G., Bossi P., et al. An independent prognostic indicator in colorectal adenocarcinomas. J. Natl. Cancer Inst. 1994, 86:681-687.
    • (1994) J. Natl. Cancer Inst. , vol.86 , pp. 681-687
    • Bosari, S.1    Viale, G.2    Bossi, P.3
  • 3
    • 0022623436 scopus 로고
    • Human p53 gene localized to short arm of chromosome 17
    • Miller C., Mohandas T., Wolf D., et al. Human p53 gene localized to short arm of chromosome 17. Nature 1986, 319:783-784.
    • (1986) Nature , vol.319 , pp. 783-784
    • Miller, C.1    Mohandas, T.2    Wolf, D.3
  • 4
    • 0027232043 scopus 로고
    • Overexpression of p53 is a late event in the development of malignant melanoma
    • Lassam N., From L., Kahn H. Overexpression of p53 is a late event in the development of malignant melanoma. Cancer Res. 1993, 53:2235-2238.
    • (1993) Cancer Res. , vol.53 , pp. 2235-2238
    • Lassam, N.1    From, L.2    Kahn, H.3
  • 5
    • 0028088897 scopus 로고
    • Association of p53 mutations with short survival in colorectal cancer
    • Hamelin R., Laurent-Puig P., Alschwang S., et al. Association of p53 mutations with short survival in colorectal cancer. Gastroenterology 1994, 106:42-48.
    • (1994) Gastroenterology , vol.106 , pp. 42-48
    • Hamelin, R.1    Laurent-Puig, P.2    Alschwang, S.3
  • 6
    • 16044375068 scopus 로고    scopus 로고
    • Concordance between p53 protein overexpression and gene mutation in a large series of common human carcinomas
    • Soong R., Robbins P., Dix B., et al. Concordance between p53 protein overexpression and gene mutation in a large series of common human carcinomas. Hum. Pathol. 1996, 27:1050-1055.
    • (1996) Hum. Pathol. , vol.27 , pp. 1050-1055
    • Soong, R.1    Robbins, P.2    Dix, B.3
  • 7
    • 0025743791 scopus 로고
    • Overexpression and mutation of p53 in epithelial ovarian cancer
    • Marks J., Davidoff A., Kerns B., et al. Overexpression and mutation of p53 in epithelial ovarian cancer. Cancer Res. 1991, 51:2979-2984.
    • (1991) Cancer Res. , vol.51 , pp. 2979-2984
    • Marks, J.1    Davidoff, A.2    Kerns, B.3
  • 8
    • 84862858499 scopus 로고
    • P53 and K-ras gene mutations in epithelial ovarian neoplasms
    • Kupryjanczyk J., Thor A., Beauchamp R., et al. P53 and K-ras gene mutations in epithelial ovarian neoplasms. Cancer Res. 1993, 53:1-6.
    • (1993) Cancer Res. , vol.53 , pp. 1-6
    • Kupryjanczyk, J.1    Thor, A.2    Beauchamp, R.3
  • 9
    • 0028224376 scopus 로고
    • Relationship of p53 overexpression and up-regulation of proliferating cell nuclear antigen with the clinical course of non-small cell lung cancer
    • Ebina M., Steinberg S., Muishine J., et al. Relationship of p53 overexpression and up-regulation of proliferating cell nuclear antigen with the clinical course of non-small cell lung cancer. Cancer Res. 1994, 54:2496-2503.
    • (1994) Cancer Res. , vol.54 , pp. 2496-2503
    • Ebina, M.1    Steinberg, S.2    Muishine, J.3
  • 10
    • 0026786636 scopus 로고
    • Prognostice significance of p53 overexpression in gastric and colorectal carcinoma
    • Starzynska T., Bromley M., Ghosh A., et al. Prognostice significance of p53 overexpression in gastric and colorectal carcinoma. Br. J. Cancer 1992, 66:558-562.
    • (1992) Br. J. Cancer , vol.66 , pp. 558-562
    • Starzynska, T.1    Bromley, M.2    Ghosh, A.3
  • 11
    • 0036899257 scopus 로고    scopus 로고
    • Mutated p53 as a molecular marker for the diagnosis of head and neck cancer
    • van Houten V., Tabor M., van den Brekel M., et al. Mutated p53 as a molecular marker for the diagnosis of head and neck cancer. J. Pathol. 2002, 198:476-486.
    • (2002) J. Pathol. , vol.198 , pp. 476-486
    • van Houten, V.1    Tabor, M.2    van den Brekel, M.3
  • 12
    • 0026694826 scopus 로고
    • Two distinct mechanisms alter p53 in breast cancer: Mutation and nuclear exclusion
    • Moll U., Riou G., Levine A. Two distinct mechanisms alter p53 in breast cancer: Mutation and nuclear exclusion. Proc. Natl. Acad. Sci. USA 1992, 89:7262-7266.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 7262-7266
    • Moll, U.1    Riou, G.2    Levine, A.3
  • 13
    • 0028129236 scopus 로고
    • Comparison of p53 gene mutation and protein overexpression in colorectal carcinomas
    • Dix B., Robbins P., Carello S., et al. Comparison of p53 gene mutation and protein overexpression in colorectal carcinomas. Br. J. Cancer 1994, 70:585-590.
    • (1994) Br. J. Cancer , vol.70 , pp. 585-590
    • Dix, B.1    Robbins, P.2    Carello, S.3
  • 14
    • 0027204173 scopus 로고
    • Large E1B proteins of adenovirus types 5 and 12 have different effects on p53 and distinct roles in cell transformation
    • van den Heuvel S., van Laar T., The I., et al. Large E1B proteins of adenovirus types 5 and 12 have different effects on p53 and distinct roles in cell transformation. J. Virol. 1993, 67:5226-5234.
    • (1993) J. Virol. , vol.67 , pp. 5226-5234
    • van den Heuvel, S.1    van Laar, T.2    The, I.3
  • 15
    • 0029049828 scopus 로고
    • Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors
    • Moll U., LaQuaglia M., Benard J., et al. Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors. Proc. Natl. Acad. Sci. USA 1995, 92:4407-4411.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 4407-4411
    • Moll, U.1    LaQuaglia, M.2    Benard, J.3
  • 16
    • 0026741643 scopus 로고
    • Inhibition of DNA synthesis by TGF-beta1 conincides with inhibition of phosphorylation and cytoplasmic translocation of p53 protein
    • Suzuki K., Ono T., Takahashi K. Inhibition of DNA synthesis by TGF-beta1 conincides with inhibition of phosphorylation and cytoplasmic translocation of p53 protein. Biochem. Biophys. Res. Commun. 1992, 183:1175-1183.
    • (1992) Biochem. Biophys. Res. Commun. , vol.183 , pp. 1175-1183
    • Suzuki, K.1    Ono, T.2    Takahashi, K.3
  • 17
    • 0024452546 scopus 로고
    • P53: A frequent target for genetic abnormalities in lung cancer
    • Takahashi T., Nau N., Chiba I., et al. P53: A frequent target for genetic abnormalities in lung cancer. Science 1989, 246:491-494.
    • (1989) Science , vol.246 , pp. 491-494
    • Takahashi, T.1    Nau, N.2    Chiba, I.3
  • 18
    • 0027184721 scopus 로고
    • Molecular chaperone functions of heat-shock proteins
    • Hendrick J., Hartl F. Molecular chaperone functions of heat-shock proteins. Annu. Rev. Biochem. 1993, 62:349-384.
    • (1993) Annu. Rev. Biochem. , vol.62 , pp. 349-384
    • Hendrick, J.1    Hartl, F.2
  • 19
    • 77954947810 scopus 로고    scopus 로고
    • The HSP70 chaperone machinery: J proteins as drivers of functional specificity
    • Kampinga H., Craig E. The HSP70 chaperone machinery: J proteins as drivers of functional specificity. Nat. Rev. Mol. Cell Biol. 2010, 11:579-592.
    • (2010) Nat. Rev. Mol. Cell Biol. , vol.11 , pp. 579-592
    • Kampinga, H.1    Craig, E.2
  • 20
    • 77954955686 scopus 로고    scopus 로고
    • Heat shock factors: Integrators of cell stress, development and lifespan
    • Akerfelt M., Morimoto R., Sistonen L. Heat shock factors: Integrators of cell stress, development and lifespan. Nat. Rev. Mol. Cell Biol. 2010, 11:545-555.
    • (2010) Nat. Rev. Mol. Cell Biol. , vol.11 , pp. 545-555
    • Akerfelt, M.1    Morimoto, R.2    Sistonen, L.3
  • 21
    • 33847651284 scopus 로고    scopus 로고
    • Three faces of mortalin: A housekeeper, guardian and killer
    • Kaul S., Deocaris C., Wadhwa R. Three faces of mortalin: A housekeeper, guardian and killer. Exp. Gerontol 2007, 42:263-274.
    • (2007) Exp. Gerontol , vol.42 , pp. 263-274
    • Kaul, S.1    Deocaris, C.2    Wadhwa, R.3
  • 22
    • 33744485567 scopus 로고    scopus 로고
    • Structural and functional differences between mouse Mot-1 and Mot-2 proteins that differ in two amino acids
    • Deocaris C., Yamasaki K., Kaul S., et al. Structural and functional differences between mouse Mot-1 and Mot-2 proteins that differ in two amino acids. Ann. NY Acad. Sci. 2006, 1067:220-223.
    • (2006) Ann. NY Acad. Sci. , vol.1067 , pp. 220-223
    • Deocaris, C.1    Yamasaki, K.2    Kaul, S.3
  • 23
    • 52449097027 scopus 로고    scopus 로고
    • Unusual cellular disposition of the mitochondrial molecular chaperones Hsp60, Hsp70, and Hsp10
    • Gupta R., Ramachandra N., Bowes T., et al. Unusual cellular disposition of the mitochondrial molecular chaperones Hsp60, Hsp70, and Hsp10. Novart. Fdn. Symp. 2008, 291:59-68.
    • (2008) Novart. Fdn. Symp. , vol.291 , pp. 59-68
    • Gupta, R.1    Ramachandra, N.2    Bowes, T.3
  • 24
    • 0036815606 scopus 로고    scopus 로고
    • Mortalin: Present and prospective
    • Kaul S., Taira K., Pereira-Smith O., et al. Mortalin: Present and prospective. Exp. Gerontol 2002, 37:1157-1164.
    • (2002) Exp. Gerontol , vol.37 , pp. 1157-1164
    • Kaul, S.1    Taira, K.2    Pereira-Smith, O.3
  • 25
    • 0027227379 scopus 로고
    • Differential subcellular distribution of mortalin in mortal and immortal mouse and human fibroblasts
    • Wadhwa R., Kaul S., Mitsui Y., et al. Differential subcellular distribution of mortalin in mortal and immortal mouse and human fibroblasts. Exp. Cell Res. 1993, 207:442-448.
    • (1993) Exp. Cell Res. , vol.207 , pp. 442-448
    • Wadhwa, R.1    Kaul, S.2    Mitsui, Y.3
  • 26
    • 2542482495 scopus 로고    scopus 로고
    • Hsp90-binding immunophilins linkp53 to dynein during p53 transport to the nucleus
    • Galigniana M., Harrell J., O'Hagen H., et al. Hsp90-binding immunophilins linkp53 to dynein during p53 transport to the nucleus. J. Biol. Chem. 2004, 279:22483-22489.
    • (2004) J. Biol. Chem. , vol.279 , pp. 22483-22489
    • Galigniana, M.1    Harrell, J.2    O'Hagen, H.3
  • 27
    • 0034306461 scopus 로고    scopus 로고
    • P53 is associated with cellular microtubules and is transported to the nucleus by dynein
    • Giannakakou P., Sackett D., Ward Y., et al. P53 is associated with cellular microtubules and is transported to the nucleus by dynein. Nat. Cell Biol. 2000, 2:709-717.
    • (2000) Nat. Cell Biol. , vol.2 , pp. 709-717
    • Giannakakou, P.1    Sackett, D.2    Ward, Y.3
  • 28
    • 0036678880 scopus 로고    scopus 로고
    • Enhance microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics
    • Giannakakou P., Nakano M., Nicolaou K., et al. Enhance microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics. Proc. Natl. Acad. Sci. USA 2002, 99:10855-10860.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 10855-10860
    • Giannakakou, P.1    Nakano, M.2    Nicolaou, K.3
  • 29
    • 24644457314 scopus 로고    scopus 로고
    • Complicating the complexity of p53
    • Yee K., Vousden K. Complicating the complexity of p53. Carcinogenesis 2005, 26:1317-1322.
    • (2005) Carcinogenesis , vol.26 , pp. 1317-1322
    • Yee, K.1    Vousden, K.2
  • 30
    • 0027414085 scopus 로고
    • Identification of a novel member of mouse hsp70 family. Its association with cellular mortal phenotype
    • Wadhwa R., Kaul S., Ikawa Y., et al. Identification of a novel member of mouse hsp70 family. Its association with cellular mortal phenotype. J. Biol. Chem. 1993, 268:6615-6621.
    • (1993) J. Biol. Chem. , vol.268 , pp. 6615-6621
    • Wadhwa, R.1    Kaul, S.2    Ikawa, Y.3
  • 31
    • 33646409045 scopus 로고    scopus 로고
    • Upregulation of mortalin/mthsp70/Grp75 contributes to human carcinogenesis
    • Wadhwa R., Takano S., Kamaljit K., et al. Upregulation of mortalin/mthsp70/Grp75 contributes to human carcinogenesis. Int. J. Cancer 2006, 118:2973-2980.
    • (2006) Int. J. Cancer , vol.118 , pp. 2973-2980
    • Wadhwa, R.1    Takano, S.2    Kamaljit, K.3
  • 32
    • 0030048389 scopus 로고    scopus 로고
    • Cytoplasmic sequestration of wild-type p53 protein impairs the G1 checkpoint after DNA damage
    • Moll U., Ostermeyer A., Haladay R., et al. Cytoplasmic sequestration of wild-type p53 protein impairs the G1 checkpoint after DNA damage. Mol. Cell Biol. 1996, 16:1126-1137.
    • (1996) Mol. Cell Biol. , vol.16 , pp. 1126-1137
    • Moll, U.1    Ostermeyer, A.2    Haladay, R.3
  • 33
    • 11144349225 scopus 로고    scopus 로고
    • Mortalin is over-expressed by colorectal adenocarcinomas and correlates with poor survival
    • Dundas S., Lawrie L., Rooney P., et al. Mortalin is over-expressed by colorectal adenocarcinomas and correlates with poor survival. J. Pathol. 2005, 205:74-81.
    • (2005) J. Pathol. , vol.205 , pp. 74-81
    • Dundas, S.1    Lawrie, L.2    Rooney, P.3
  • 34
    • 0030965946 scopus 로고    scopus 로고
    • Regulation of p53 stability by Mdm2
    • Kubbutat M., Jones S., Vousden K. Regulation of p53 stability by Mdm2. Nature 1997, 387:299-303.
    • (1997) Nature , vol.387 , pp. 299-303
    • Kubbutat, M.1    Jones, S.2    Vousden, K.3
  • 35
    • 0030853074 scopus 로고    scopus 로고
    • Expression of wild-type p53 is required for efficient global genomic nucleotide excision repair in UV-irradiated human fibroblasts
    • Ford J., Hanawalt P. Expression of wild-type p53 is required for efficient global genomic nucleotide excision repair in UV-irradiated human fibroblasts. J. Biol. Chem. 1997, 272:28073-28080.
    • (1997) J. Biol. Chem. , vol.272 , pp. 28073-28080
    • Ford, J.1    Hanawalt, P.2
  • 36
    • 0036479115 scopus 로고    scopus 로고
    • Transcriptional repression of the anti-apoptotic surviving gene by wild type p53
    • Hoffman W., Biade S., Zilfou J., et al. Transcriptional repression of the anti-apoptotic surviving gene by wild type p53. J. Biol. Chem. 2002, 277:3247-3257.
    • (2002) J. Biol. Chem. , vol.277 , pp. 3247-3257
    • Hoffman, W.1    Biade, S.2    Zilfou, J.3
  • 37
    • 0031665673 scopus 로고    scopus 로고
    • P53 mutation, but not p53 overexpression, correlates with survival n head and neck squamous cell carcinoma
    • Mineta H., Borg A., Dictor M., et al. P53 mutation, but not p53 overexpression, correlates with survival n head and neck squamous cell carcinoma. Br. J. Cancer 1998, 78:1084-1090.
    • (1998) Br. J. Cancer , vol.78 , pp. 1084-1090
    • Mineta, H.1    Borg, A.2    Dictor, M.3
  • 38
    • 0031586587 scopus 로고    scopus 로고
    • Elevated levels of mortalin expression in human brain tumors
    • Takano S., Wadhwa R., Yoshii Y., et al. Elevated levels of mortalin expression in human brain tumors. Exp. Cell Res. 1997, 237:38-45.
    • (1997) Exp. Cell Res. , vol.237 , pp. 38-45
    • Takano, S.1    Wadhwa, R.2    Yoshii, Y.3
  • 39
    • 39749200037 scopus 로고    scopus 로고
    • Association of mortalin (HSP9) with liver cancer metastasis and prediction for early tumor recurrence
    • Yi X., Luk J., Lee N., et al. Association of mortalin (HSP9) with liver cancer metastasis and prediction for early tumor recurrence. Mol. Cell. Proteomics 2008, 7:315-325.
    • (2008) Mol. Cell. Proteomics , vol.7 , pp. 315-325
    • Yi, X.1    Luk, J.2    Lee, N.3
  • 40
    • 2342651518 scopus 로고    scopus 로고
    • Molecular chaperones and the stress of oncogenesis
    • Mosser D., Morimoto R. Molecular chaperones and the stress of oncogenesis. Oncogene 2004, 23:2907-2918.
    • (2004) Oncogene , vol.23 , pp. 2907-2918
    • Mosser, D.1    Morimoto, R.2
  • 42
    • 33845952225 scopus 로고    scopus 로고
    • Revisiting the role of p53 in primary and secondary glioblastomas
    • Nagpal J., Jamoona A., Gulati N., et al. Revisiting the role of p53 in primary and secondary glioblastomas. Anticancer Res. 2006, 26:4633-4639.
    • (2006) Anticancer Res. , vol.26 , pp. 4633-4639
    • Nagpal, J.1    Jamoona, A.2    Gulati, N.3
  • 43
    • 0037428078 scopus 로고    scopus 로고
    • Parc: A cytoplasmic anchor for p53
    • Nikolaev A., Li M., Puskas N., et al. Parc: A cytoplasmic anchor for p53. Cell 2003, 112:29-40.
    • (2003) Cell , vol.112 , pp. 29-40
    • Nikolaev, A.1    Li, M.2    Puskas, N.3
  • 44
    • 77955241980 scopus 로고    scopus 로고
    • Silencing heat shock protein 27 decreases metastatic behavior of human head and neck squamous call cancer cells in vitro
    • Zhu Z., Xu X., Graham M., et al. Silencing heat shock protein 27 decreases metastatic behavior of human head and neck squamous call cancer cells in vitro. Mol. Pharm. 2010, 7:1283-1290.
    • (2010) Mol. Pharm. , vol.7 , pp. 1283-1290
    • Zhu, Z.1    Xu, X.2    Graham, M.3
  • 45
    • 84862895649 scopus 로고    scopus 로고
    • HSP-27 protein expression in uveal melanomas: Correlation with predicted survival
    • Jmor F., Kalirai H., Taktak A., et al. HSP-27 protein expression in uveal melanomas: Correlation with predicted survival. Acta Ophthalmol 2010, 88:1-7.
    • (2010) Acta Ophthalmol , vol.88 , pp. 1-7
    • Jmor, F.1    Kalirai, H.2    Taktak, A.3


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