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Volumn 2, Issue 12, 2011, Pages 1097-1105

Vascular Endothelial Growth Factor (VEGF) and Its Receptor (VEGFR) Signaling in Angiogenesis: A Crucial Target for Anti- and Pro-Angiogenic Therapies

Author keywords

anti angiogenic therapy; neuronal degeneration; pro angiogenic therapy; tumor angiogenesis; VEGF; VEGF receptor

Indexed keywords

ANGIOGENESIS INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOLIPASE C GAMMA; PLATELET DERIVED GROWTH FACTOR; PROTEIN KINASE C; VASCULOTROPIN; VASCULOTROPIN A; VASCULOTROPIN B; VASCULOTROPIN C; VASCULOTROPIN D; VASCULOTROPIN E; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 1;

EID: 84868618639     PISSN: 19476019     EISSN: 19476027     Source Type: Journal    
DOI: 10.1177/1947601911423031     Document Type: Article
Times cited : (1197)

References (64)
  • 1
    • 0030952289 scopus 로고    scopus 로고
    • Mechanism of angiogenesis
    • Risau W.Mechanism of angiogenesis.Nature. 1997;386:671-4.
    • (1997) Nature , vol.386 , pp. 671-674
    • Risau, W.1
  • 2
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • Hanahan D,Folkman J.Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis.Cell. 1996;86:353-64.
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 3
    • 30744449235 scopus 로고    scopus 로고
    • Angiogenesis as a therapeutic target
    • Ferrara N,Kerbel RS.Angiogenesis as a therapeutic target.Nature. 2005;438:967-74.
    • (2005) Nature , vol.438 , pp. 967-974
    • Ferrara, N.1    Kerbel, R.S.2
  • 4
    • 0028842903 scopus 로고
    • Role of VEGF-Flt receptor system in normal and tumor angiogenesis
    • Shibuya M.Role of VEGF-Flt receptor system in normal and tumor angiogenesis.Adv Cancer Res. 1995;67:281-316.
    • (1995) Adv Cancer Res , vol.67 , pp. 281-316
    • Shibuya, M.1
  • 5
    • 33344474964 scopus 로고    scopus 로고
    • Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis
    • Shibuya M,Claesson-Welsh L.Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis.Exp Cell Res. 2006;312:549-60.
    • (2006) Exp Cell Res , vol.312 , pp. 549-560
    • Shibuya, M.1    Claesson-Welsh, L.2
  • 6
    • 0036527585 scopus 로고    scopus 로고
    • Molecular mechanisms of lymphangiogenesis in health and disease
    • Alitalo K,Carmeliet P.Molecular mechanisms of lymphangiogenesis in health and disease.Cancer Cell. 2002;1:219-27.
    • (2002) Cancer Cell , vol.1 , pp. 219-227
    • Alitalo, K.1    Carmeliet, P.2
  • 7
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H,Fehrenbacher L,Novotny W, et al.Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer.N Engl J Med. 2004;350:2335-42.
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 8
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
    • Sandler A,Gray R,Perry MC, et al.Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer.N Engl J Med. 2006;355:2542-50.
    • (2006) N Engl J Med , vol.355 , pp. 2542-2550
    • Sandler, A.1    Gray, R.2    Perry, M.C.3
  • 9
    • 0021111648 scopus 로고
    • Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
    • Senger DR,Galli SJ,Dvorak AM, et al.Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid.Science. 1983;219:983-5.
    • (1983) Science , vol.219 , pp. 983-985
    • Senger, D.R.1    Galli, S.J.2    Dvorak, A.M.3
  • 10
    • 0024818355 scopus 로고
    • Vascular endothelial growth factor is a secreted angiogenic mitogen
    • Leung DW,Cachianes G,Kuang W-J, et al.Vascular endothelial growth factor is a secreted angiogenic mitogen.Science. 1989;246:1306-9.
    • (1989) Science , vol.246 , pp. 1306-1309
    • Leung, D.W.1    Cachianes, G.2    Kuang, W.-J.3
  • 11
    • 0030795733 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: crystal structure and functional mapping of the kinase domain receptor binding site
    • Muller YA,Li B,Christinger HW,Wells JA,Cunningham BC,de Vos AM.Vascular endothelial growth factor: crystal structure and functional mapping of the kinase domain receptor binding site.Proc Natl Acad Sci U S A. 1997;94:7192-7.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 7192-7197
    • Muller, Y.A.1    Li, B.2    Christinger, H.W.3    Wells, J.A.4    Cunningham, B.C.5    de Vos, A.M.6
  • 12
    • 0037631338 scopus 로고    scopus 로고
    • A set of loop-1 and -3 structures in the novel VEGF family member, VEGF-ENZ-7, is essential for the activation of VEGFR-2 signaling
    • Kiba A,Yabana N,Shibuya M.A set of loop-1 and -3 structures in the novel VEGF family member, VEGF-ENZ-7, is essential for the activation of VEGFR-2 signaling.J Biol Chem. 2003;278:13453-61.
    • (2003) J Biol Chem , vol.278 , pp. 13453-13461
    • Kiba, A.1    Yabana, N.2    Shibuya, M.3
  • 13
    • 0036166701 scopus 로고    scopus 로고
    • Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188
    • Maes C,Carmeliet P,Moermans K, et al.Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188.Mech Dev. 2002;111:61-73.
    • (2002) Mech Dev , vol.111 , pp. 61-73
    • Maes, C.1    Carmeliet, P.2    Moermans, K.3
  • 14
    • 34447316207 scopus 로고    scopus 로고
    • Expression of VEGF(xxx)b, the inhibitory isoforms of VEGF, in malignant melanoma
    • Pritchard-Jones RO,Dunn DB,Qiu Y, et al.Expression of VEGF(xxx)b, the inhibitory isoforms of VEGF, in malignant melanoma.Br J Cancer. 2007;97:223-30.
    • (2007) Br J Cancer , vol.97 , pp. 223-230
    • Pritchard-Jones, R.O.1    Dunn, D.B.2    Qiu, Y.3
  • 15
    • 34547941252 scopus 로고    scopus 로고
    • Autocrine VEGF signaling is required for vascular homeostasis
    • Lee S,Chen TT,Barber CL, et al.Autocrine VEGF signaling is required for vascular homeostasis.Cell. 2007;130:691-703.
    • (2007) Cell , vol.130 , pp. 691-703
    • Lee, S.1    Chen, T.T.2    Barber, C.L.3
  • 16
    • 19244379078 scopus 로고    scopus 로고
    • Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions
    • Carmeliet P,Moons L,Luttun A, et al.Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions.Nat Med. 2001;7:575-83.
    • (2001) Nat Med , vol.7 , pp. 575-583
    • Carmeliet, P.1    Moons, L.2    Luttun, A.3
  • 17
    • 0035902538 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-B-deficient mice display an atrial conduction defect
    • Aase K,von Euler G,Li X, et al.Vascular endothelial growth factor-B-deficient mice display an atrial conduction defect.Circulation. 2001;104:358-64.
    • (2001) Circulation , vol.104 , pp. 358-364
    • Aase, K.1    von Euler, G.2    Li, X.3
  • 18
    • 79955655849 scopus 로고    scopus 로고
    • Neuronal FLT1 receptor and its selective ligand VEGF-B protect against retrograde degeneration of sensory neurons
    • Dhondt J,Peeraer E,Verheyen A, et al.Neuronal FLT1 receptor and its selective ligand VEGF-B protect against retrograde degeneration of sensory neurons.FASEB J. Epub. 2011;:19.
    • (2011) FASEB J. Epub , pp. 19
    • Dhondt, J.1    Peeraer, E.2    Verheyen, A.3
  • 19
    • 33947670424 scopus 로고    scopus 로고
    • Proprotein convertases promote processing of VEGF-D, a critical step for binding the angiogenic receptor VEGFR-2
    • McColl BK,Paavonen K,Karnezis T, et al.Proprotein convertases promote processing of VEGF-D, a critical step for binding the angiogenic receptor VEGFR-2.FASEB J. 2007;21:1088-98.
    • (2007) FASEB J , vol.21 , pp. 1088-1098
    • McColl, B.K.1    Paavonen, K.2    Karnezis, T.3
  • 20
    • 0027979253 scopus 로고
    • Homologs of vascular endothelial growth factor are encoded by the poxvirus orf virus
    • Lyttle DJ,Fraser KM,Fleming SB,Mercer AA,Robinson AJ.Homologs of vascular endothelial growth factor are encoded by the poxvirus orf virus.J Virol. 1994;68:84-92.
    • (1994) J Virol , vol.68 , pp. 84-92
    • Lyttle, D.J.1    Fraser, K.M.2    Fleming, S.B.3    Mercer, A.A.4    Robinson, A.J.5
  • 21
    • 0032553299 scopus 로고    scopus 로고
    • A novel type of vascular endothelial growth factor: VEGF-E (NZ-7 VEGF) preferentially utilizes KDR/Flk-1 receptor and carries a potent mitotic activity without heparin-binding domain
    • Ogawa S,Oku A,Sawano A,Yamaguchi S,Yazaki Y,Shibuya M.A novel type of vascular endothelial growth factor: VEGF-E (NZ-7 VEGF) preferentially utilizes KDR/Flk-1 receptor and carries a potent mitotic activity without heparin-binding domain.J Biol Chem. 1998;273:31273-82.
    • (1998) J Biol Chem , vol.273 , pp. 31273-31282
    • Ogawa, S.1    Oku, A.2    Sawano, A.3    Yamaguchi, S.4    Yazaki, Y.5    Shibuya, M.6
  • 22
    • 0033556287 scopus 로고    scopus 로고
    • A novel vascular endothelial growth factor encoded by Orf virus, VEGF-E, mediates angiogenesis via signalling through VEGFR-2 (KDR) but not VEGFR-1 (Flt-1) receptor tyrosine kinases
    • Meyer M,Clauss M,Lepple-Wienhues A, et al.A novel vascular endothelial growth factor encoded by Orf virus, VEGF-E, mediates angiogenesis via signalling through VEGFR-2 (KDR) but not VEGFR-1 (Flt-1) receptor tyrosine kinases.EMBO J. 1999;18:363-74.
    • (1999) EMBO J , vol.18 , pp. 363-374
    • Meyer, M.1    Clauss, M.2    Lepple-Wienhues, A.3
  • 23
    • 13044287362 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF)-like protein from orf virus NZ2 binds to VEGFR2 and neuropilin-1
    • Wise LM,Veikkola T,Mercer AA, et al.Vascular endothelial growth factor (VEGF)-like protein from orf virus NZ2 binds to VEGFR2 and neuropilin-1.Proc Natl Acad Sci U S A. 1999;96:3071-6.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 3071-3076
    • Wise, L.M.1    Veikkola, T.2    Mercer, A.A.3
  • 24
    • 0023515851 scopus 로고
    • Cell transformation by the viral src oncogene
    • Jove R,Hanafusa H.Cell transformation by the viral src oncogene.Annu Rev Cell Biol. 1987;3:31-56.
    • (1987) Annu Rev Cell Biol , vol.3 , pp. 31-56
    • Jove, R.1    Hanafusa, H.2
  • 25
    • 8544262237 scopus 로고    scopus 로고
    • A novel snake venom vascular endothelial growth factor (VEGF) predominantly induces vascular permeability through preferential signaling via VEGF receptor-1
    • Takahashi H,Hattori S,Iwamatsu A,Takizawa H,Shibuya M.A novel snake venom vascular endothelial growth factor (VEGF) predominantly induces vascular permeability through preferential signaling via VEGF receptor-1.J Biol Chem. 2004;279:46304-14.
    • (2004) J Biol Chem , vol.279 , pp. 46304-46314
    • Takahashi, H.1    Hattori, S.2    Iwamatsu, A.3    Takizawa, H.4    Shibuya, M.5
  • 26
    • 0030050025 scopus 로고    scopus 로고
    • Flt-1 but not KDR/Flk-1 tyrosine kinase is a receptor for placenta growth factor (PlGF), which is related to vascular endothelial growth factor (VEGF)
    • Sawano A,Takahashi T,Yamaguchi S,Aonuma T,Shibuya M.Flt-1 but not KDR/Flk-1 tyrosine kinase is a receptor for placenta growth factor (PlGF), which is related to vascular endothelial growth factor (VEGF).Cell Growth Diff. 1996;7:213-21.
    • (1996) Cell Growth Diff , vol.7 , pp. 213-221
    • Sawano, A.1    Takahashi, T.2    Yamaguchi, S.3    Aonuma, T.4    Shibuya, M.5
  • 27
    • 0033118228 scopus 로고    scopus 로고
    • VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells
    • Takahashi T,Ueno H,Shibuya M.VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells.Oncogene. 1999;18:2221-30.
    • (1999) Oncogene , vol.18 , pp. 2221-2230
    • Takahashi, T.1    Ueno, H.2    Shibuya, M.3
  • 28
    • 0035355472 scopus 로고    scopus 로고
    • A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-γ and DNA synthesis in vascular endothelial cells
    • Takahashi T,Yamaguchi S,Chida K,Shibuya M.A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-γ and DNA synthesis in vascular endothelial cells.EMBO J. 2001;20:2768-78.
    • (2001) EMBO J , vol.20 , pp. 2768-2778
    • Takahashi, T.1    Yamaguchi, S.2    Chida, K.3    Shibuya, M.4
  • 29
    • 12844264070 scopus 로고    scopus 로고
    • Essential role of Flk-1 (vascular endothelial growth factor receptor-2) tyrosine residue-1173 in vasculogenesis in mice
    • Sakurai Y,Ohgimoto K,Kataoka Y,Yoshida N,Shibuya M.Essential role of Flk-1 (vascular endothelial growth factor receptor-2) tyrosine residue-1173 in vasculogenesis in mice.Proc Natl Acad Sci U S A. 2005;102:1076-81.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 1076-1081
    • Sakurai, Y.1    Ohgimoto, K.2    Kataoka, Y.3    Yoshida, N.4    Shibuya, M.5
  • 30
    • 0038624399 scopus 로고    scopus 로고
    • Phospholipase C gamma-1 is required downstream of vascular endothelial growth factor during arterial development
    • Lawson ND,Mugford JW,Diamond BA,Weinstein BM.Phospholipase C gamma-1 is required downstream of vascular endothelial growth factor during arterial development.Genes Dev. 2003;7:1346-51.
    • (2003) Genes Dev , vol.7 , pp. 1346-1351
    • Lawson, N.D.1    Mugford, J.W.2    Diamond, B.A.3    Weinstein, B.M.4
  • 31
    • 69949112647 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) receptor-2 tyrosine 1175 signaling controls VEGF-induced von Willebrand factor release from endothelial cells via phospholipase C-gamma 1- and protein kinase A-dependent pathways
    • Xiong Y,Huo Y,Chen C, et al.Vascular endothelial growth factor (VEGF) receptor-2 tyrosine 1175 signaling controls VEGF-induced von Willebrand factor release from endothelial cells via phospholipase C-gamma 1- and protein kinase A-dependent pathways.J Biol Chem. 2009;284:23217-24.
    • (2009) J Biol Chem , vol.284 , pp. 23217-23224
    • Xiong, Y.1    Huo, Y.2    Chen, C.3
  • 32
    • 70350351129 scopus 로고    scopus 로고
    • VEGFR2-PLCgamma1 axis is essential for endothelial specification of VEGFR2+ vascular progenitor cells
    • Sase H,Watabe T,Kawasaki K,Miyazono K,Miyazawa K.VEGFR2-PLCgamma1 axis is essential for endothelial specification of VEGFR2+ vascular progenitor cells.J Cell Sci. 2009;122:3303-11.
    • (2009) J Cell Sci , vol.122 , pp. 3303-3311
    • Sase, H.1    Watabe, T.2    Kawasaki, K.3    Miyazono, K.4    Miyazawa, K.5
  • 33
    • 22744447871 scopus 로고    scopus 로고
    • VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis
    • Matsumoto T,Bohman S,Dixelius J, et al.VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis.EMBO J. 2005;24:2342-53.
    • (2005) EMBO J , vol.24 , pp. 2342-2353
    • Matsumoto, T.1    Bohman, S.2    Dixelius, J.3
  • 34
    • 0031577563 scopus 로고    scopus 로고
    • The phosphorylated 1169-tyrosine containing region of Flt-1 kinase (VEGFR-1) is a major binding site for PLCγ
    • Sawano A,Takahashi T,Yamaguchi S, et al.The phosphorylated 1169-tyrosine containing region of Flt-1 kinase (VEGFR-1) is a major binding site for PLCγ.Biochem Biophys Res Commun. 1997;238:487-91.
    • (1997) Biochem Biophys Res Commun , vol.238 , pp. 487-491
    • Sawano, A.1    Takahashi, T.2    Yamaguchi, S.3
  • 35
    • 79953209305 scopus 로고    scopus 로고
    • RACK1 regulates VEGF/Flt1-mediated cell migration via activation of a PI3K/Akt pathway
    • Wang F,Yamauchi M,Muramatsu M,Osawa T,Tsuchida R,Shibuya M.RACK1 regulates VEGF/Flt1-mediated cell migration via activation of a PI3K/Akt pathway.J Biol Chem. 2011;286:9097-106.
    • (2011) J Biol Chem , vol.286 , pp. 9097-9106
    • Wang, F.1    Yamauchi, M.2    Muramatsu, M.3    Osawa, T.4    Tsuchida, R.5    Shibuya, M.6
  • 36
    • 0029021660 scopus 로고
    • Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
    • Fong GH,Rossant J,Gertsentein M,Breitman ML.Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium.Nature. 1995;376:66-70.
    • (1995) Nature , vol.376 , pp. 66-70
    • Fong, G.H.1    Rossant, J.2    Gertsentein, M.3    Breitman, M.L.4
  • 37
    • 0032482978 scopus 로고    scopus 로고
    • Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice
    • Hiratsuka S,Minowa O,Kuno J,Noda T,Shibuya M.Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice.Proc Natl Acad Sci U S A. 1998;95:9349-54.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 9349-9354
    • Hiratsuka, S.1    Minowa, O.2    Kuno, J.3    Noda, T.4    Shibuya, M.5
  • 38
    • 54749092522 scopus 로고    scopus 로고
    • Flt-1 signaling in macrophages promotes glioma growth in vivo
    • Kerber M,Reiss Y,Wickersheim A, et al.Flt-1 signaling in macrophages promotes glioma growth in vivo.Cancer Res. 2008;68:7342-51.
    • (2008) Cancer Res , vol.68 , pp. 7342-7351
    • Kerber, M.1    Reiss, Y.2    Wickersheim, A.3
  • 39
    • 78049278304 scopus 로고    scopus 로고
    • VEGF-1 signaling promotes mobilization of macrophage-lineage cells from bone marrow and stimulateolid tumor growth
    • Muramatsu M,Yamamoto S,Osawa T,Shibuya M.VEGF-1 signaling promotes mobilization of macrophage-lineage cells from bone marrow and stimulateolid tumor growth.Cancer Res. 2010;70:8211-21.
    • (2010) Cancer Res , vol.70 , pp. 8211-8221
    • Muramatsu, M.1    Yamamoto, S.2    Osawa, T.3    Shibuya, M.4
  • 40
    • 0036782035 scopus 로고    scopus 로고
    • MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung specific metastasis
    • Hiratsuka S,Nakamura K,Iwai S, et al.MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung specific metastasis.Cancer Cell. 2002;2:289-300.
    • (2002) Cancer Cell , vol.2 , pp. 289-300
    • Hiratsuka, S.1    Nakamura, K.2    Iwai, S.3
  • 41
    • 33748703844 scopus 로고    scopus 로고
    • Signaling of vascular endothelial growth factor receptor-1 tyrosine kinase promotes rheumatoid arthritis through activation of monocyte/macrophages
    • Murakami M,Iwai S,Hiratsuka S, et al.Signaling of vascular endothelial growth factor receptor-1 tyrosine kinase promotes rheumatoid arthritis through activation of monocyte/macrophages.Blood. 2006;108:1849-56.
    • (2006) Blood , vol.108 , pp. 1849-1856
    • Murakami, M.1    Iwai, S.2    Hiratsuka, S.3
  • 42
    • 28644432204 scopus 로고    scopus 로고
    • VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
    • Kaplan RN,Riba RD,Zacharoulis S, et al.VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche.Nature. 2005;438:820-7.
    • (2005) Nature , vol.438 , pp. 820-827
    • Kaplan, R.N.1    Riba, R.D.2    Zacharoulis, S.3
  • 43
    • 33747498714 scopus 로고    scopus 로고
    • The vascular endothelial growth factor receptor (VEGFR-1) supports growth and survival of human breast carcinoma
    • Wu Y,Hooper AT,Zhong Z, et al.The vascular endothelial growth factor receptor (VEGFR-1) supports growth and survival of human breast carcinoma.Int J Cancer. 2006;119:1519-29.
    • (2006) Int J Cancer , vol.119 , pp. 1519-1529
    • Wu, Y.1    Hooper, A.T.2    Zhong, Z.3
  • 44
    • 0025259592 scopus 로고
    • Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family
    • Shibuya M,Yamaguchi S,Yamane A, et al.Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family.Oncogene. 1990;5:519-24.
    • (1990) Oncogene , vol.5 , pp. 519-524
    • Shibuya, M.1    Yamaguchi, S.2    Yamane, A.3
  • 45
    • 0027421333 scopus 로고
    • Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor
    • Kendall RL,Thomas KA.Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor.Proc Natl Acad Sci U S A. 1993;90:10705-9.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 10705-10709
    • Kendall, R.L.1    Thomas, K.A.2
  • 46
    • 0032570774 scopus 로고    scopus 로고
    • Genomic organization of the flt-1 gene encoding for vascular endothelial growth factor (VEGF) receptor-1 suggests an intimate evolutionary relationship between the 7-Ig and the 5-Ig tyrosine kinase receptors
    • Kondo K,Hiratsuka S,Subbalakshmi E,Matsushime H,Shibuya M.Genomic organization of the flt-1 gene encoding for vascular endothelial growth factor (VEGF) receptor-1 suggests an intimate evolutionary relationship between the 7-Ig and the 5-Ig tyrosine kinase receptors.Gene. 1998;208:297-305.
    • (1998) Gene , vol.208 , pp. 297-305
    • Kondo, K.1    Hiratsuka, S.2    Subbalakshmi, E.3    Matsushime, H.4    Shibuya, M.5
  • 47
    • 0037373006 scopus 로고    scopus 로고
    • Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia
    • Maynard SE,Min JY,Merchan J, et al.Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia.J Clin Invest. 2003;111:649-58.
    • (2003) J Clin Invest , vol.111 , pp. 649-658
    • Maynard, S.E.1    Min, J.Y.2    Merchan, J.3
  • 48
    • 0038030642 scopus 로고    scopus 로고
    • Elevated serum soluble vascular endothelial growth factor receptor 1 (sVEGFR-1) levels in women with preeclampsia
    • Koga K,Osuga Y,Yoshino O, et al.Elevated serum soluble vascular endothelial growth factor receptor 1 (sVEGFR-1) levels in women with preeclampsia.J Clin Endocrinol Metab. 2003;88:2348-51.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 2348-2351
    • Koga, K.1    Osuga, Y.2    Yoshino, O.3
  • 49
    • 10744227199 scopus 로고    scopus 로고
    • Circulating angiogenic factors and the risk of preeclampsia
    • Levine RJ,Maynard SE,Qian C, et al.Circulating angiogenic factors and the risk of preeclampsia.N Engl J Med. 2004;350:672-83.
    • (2004) N Engl J Med , vol.350 , pp. 672-683
    • Levine, R.J.1    Maynard, S.E.2    Qian, C.3
  • 50
    • 33750430869 scopus 로고    scopus 로고
    • Corneal avascularity is due to soluble VEGF receptor-1
    • Ambati BK,Nozaki M,Singh N, et al.Corneal avascularity is due to soluble VEGF receptor-1.Nature. 2006;443:993-7.
    • (2006) Nature , vol.443 , pp. 993-997
    • Ambati, B.K.1    Nozaki, M.2    Singh, N.3
  • 51
    • 77953406205 scopus 로고    scopus 로고
    • Role of bevacizumab therapy in the management of glioblastoma
    • Peak SJ,Levin VA.Role of bevacizumab therapy in the management of glioblastoma.Cancer Manag Res. 2010;2:97-104.
    • (2010) Cancer Manag Res , vol.2 , pp. 97-104
    • Peak, S.J.1    Levin, V.A.2
  • 52
    • 19644378474 scopus 로고    scopus 로고
    • Rationale for antiangiogenic cancer therapy with vaccination using epitope peptides derived from human vascular endothelial growth factor receptor 2
    • Wada S,Tsunoda T,Baba T, et al.Rationale for antiangiogenic cancer therapy with vaccination using epitope peptides derived from human vascular endothelial growth factor receptor 2.Cancer Res. 2005;65:4939-46.
    • (2005) Cancer Res , vol.65 , pp. 4939-4946
    • Wada, S.1    Tsunoda, T.2    Baba, T.3
  • 53
    • 77950960449 scopus 로고    scopus 로고
    • Further pharmacological and genetic evidence for the efficacy of PlGF inhibition in cancer and eye disease
    • Van de,Veire S,Stalmans I,Heindryckx F, et al.Further pharmacological and genetic evidence for the efficacy of PlGF inhibition in cancer and eye disease.Cell. 2010;141:178-90.
    • (2010) Cell , vol.141 , pp. 178-190
    • van de Veire, S.1    Stalmans, I.2    Heindryckx, F.3
  • 54
    • 77950953984 scopus 로고    scopus 로고
    • PlGF blockade does not inhibit angiogenesis during primary tumor growth
    • Bais C,Wu X,Yao J, et al.PlGF blockade does not inhibit angiogenesis during primary tumor growth.Cell. 2010;141:166-77.
    • (2010) Cell , vol.141 , pp. 166-177
    • Bais, C.1    Wu, X.2    Yao, J.3
  • 55
    • 0027197245 scopus 로고
    • Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
    • Kim KJ,Li B,Winer J, et al.Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo.Nature. 1993;362:841-4.
    • (1993) Nature , vol.362 , pp. 841-844
    • Kim, K.J.1    Li, B.2    Winer, J.3
  • 56
    • 35748970483 scopus 로고    scopus 로고
    • Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization
    • Fukumura D,Jain RK.Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization.Microvasc Res. 2007;74:72-84.
    • (2007) Microvasc Res , vol.74 , pp. 72-84
    • Fukumura, D.1    Jain, R.K.2
  • 57
    • 58149456505 scopus 로고    scopus 로고
    • Efficacy, safety and patterns of response and recurrence in patients with recurrent high-grade gliomas treated with bevacizumab plus irinotecan
    • Zuniga RM,Torcuator R,Jain R, et al.Efficacy, safety and patterns of response and recurrence in patients with recurrent high-grade gliomas treated with bevacizumab plus irinotecan.J Neurooncol. 2009;91:329-36.
    • (2009) J Neurooncol , vol.91 , pp. 329-336
    • Zuniga, R.M.1    Torcuator, R.2    Jain, R.3
  • 58
    • 26644471951 scopus 로고    scopus 로고
    • Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
    • Casanovas O,Hicklin DJ,Bergers G,Hanahan D.Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors.Cancer Cell. 2005;8:299-309.
    • (2005) Cancer Cell , vol.8 , pp. 299-309
    • Casanovas, O.1    Hicklin, D.J.2    Bergers, G.3    Hanahan, D.4
  • 59
    • 65349179595 scopus 로고    scopus 로고
    • Hypoxia and low nutrition double stress induces aggressiveness in a murine model of melanoma
    • Osawa T,Muramatsu M,Watanabe M,Shibuya M.Hypoxia and low nutrition double stress induces aggressiveness in a murine model of melanoma.Cancer Sci. 2009;100:844-51.
    • (2009) Cancer Sci , vol.100 , pp. 844-851
    • Osawa, T.1    Muramatsu, M.2    Watanabe, M.3    Shibuya, M.4
  • 60
    • 0034978562 scopus 로고    scopus 로고
    • Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration
    • Oosthuyse B,Moons L,Storkebaum E, et al.Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration.Nat Genet. 2001;28:131-8.
    • (2001) Nat Genet , vol.28 , pp. 131-138
    • Oosthuyse, B.1    Moons, L.2    Storkebaum, E.3
  • 61
    • 16644382257 scopus 로고    scopus 로고
    • Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS
    • Storkebaum E,Lambrechts D,Dewerchin M, et al.Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS.Nat Neurosci. 2005;8:85-92.
    • (2005) Nat Neurosci , vol.8 , pp. 85-92
    • Storkebaum, E.1    Lambrechts, D.2    Dewerchin, M.3
  • 62
    • 7144264398 scopus 로고    scopus 로고
    • Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice
    • Detmar M,Brown LF,Schon MP, et al.Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice.J Invest Dermatol. 1998;111:1-6.
    • (1998) J Invest Dermatol , vol.111 , pp. 1-6
    • Detmar, M.1    Brown, L.F.2    Schon, M.P.3
  • 63
    • 0037423716 scopus 로고    scopus 로고
    • VEGFR-2-specific ligand VEGF-E induces non- edematous hyper-vascularization in mice
    • Kiba A,Sagara H,Hara T,Shibuya M.VEGFR-2-specific ligand VEGF-E induces non- edematous hyper-vascularization in mice.Biochem Biophys Res Commun. 2003;301:371-7.
    • (2003) Biochem Biophys Res Commun , vol.301 , pp. 371-377
    • Kiba, A.1    Sagara, H.2    Hara, T.3    Shibuya, M.4
  • 64
    • 33847053649 scopus 로고    scopus 로고
    • Chimeric VEGF-ENZ7/PlGF specifically binding to VEGFR-2 accelerates skin wound healing via enhancement of neovascularization
    • Zheng Y,Watanabe M,Kuraishi T,Hattori S,Kai C,Shibuya M.Chimeric VEGF-ENZ7/PlGF specifically binding to VEGFR-2 accelerates skin wound healing via enhancement of neovascularization.Arterioscler Thromb Vasc Biol. 2007;27:503-11.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 503-511
    • Zheng, Y.1    Watanabe, M.2    Kuraishi, T.3    Hattori, S.4    Kai, C.5    Shibuya, M.6


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