메뉴 건너뛰기




Volumn 30, Issue 3, 2012, Pages 363-371

Concise review: Colorectal cancer stem cells

Author keywords

Colorectal cancer; Epithelial to mesenchymal transition; Metastasis; Microenvironment; Stem cells

Indexed keywords

ACTIVATED LEUKOCYTE CELL ADHESION MOLECULE; BETA CATENIN; BETA1 INTEGRIN; BONE MORPHOGENETIC PROTEIN; CD133 ANTIGEN; CD24 ANTIGEN; CD44V ANTIGEN; FORKHEAD TRANSCRIPTION FACTOR; G PROTEIN COUPLED RECEPTOR 54; GAMMA SECRETASE; INTERLEUKIN 1; INTERLEUKIN 6; LEUCINE; OCTAMER TRANSCRIPTION FACTOR 4; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PLATELET DERIVED GROWTH FACTOR; TELOMERASE REVERSE TRANSCRIPTASE; TRANSCRIPTION FACTOR SOX2; TUMOR NECROSIS FACTOR ALPHA; WNT PROTEIN; TUMOR MARKER;

EID: 84857491952     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.1031     Document Type: Review
Times cited : (205)

References (98)
  • 2
    • 72449176846 scopus 로고    scopus 로고
    • Molecular origins of cancer: Molecular basis of colorectal cancer
    • Markowitz SD, Bertagnolli MM. Molecular origins of cancer: Molecular basis of colorectal cancer. N Engl J Med 2009;361:2449-2460.
    • (2009) N Engl J Med , vol.361 , pp. 2449-2460
    • Markowitz, S.D.1    Bertagnolli, M.M.2
  • 4
    • 54249087106 scopus 로고    scopus 로고
    • Colon cancer stem cells: Implications for prevention and therapy
    • Huang EH, Wicha MS. Colon cancer stem cells: Implications for prevention and therapy. Trends Mol Med 2008;14:503-509.
    • (2008) Trends Mol Med , vol.14 , pp. 503-509
    • Huang, E.H.1    Wicha, M.S.2
  • 6
    • 45549085634 scopus 로고    scopus 로고
    • Human colon cancer stem cells: A new paradigm in gastrointestinal oncology
    • Boman BM, Huang E. Human colon cancer stem cells: A new paradigm in gastrointestinal oncology. J Clin Oncol 2008;26:2828-2838.
    • (2008) J Clin Oncol , vol.26 , pp. 2828-2838
    • Boman, B.M.1    Huang, E.2
  • 7
    • 79959238013 scopus 로고    scopus 로고
    • Microenvironmental regulation of stem cells in intestinal homeostasis and cancer
    • Medema JP, Vermeulen L. Microenvironmental regulation of stem cells in intestinal homeostasis and cancer. Nature 2011;474:318-326.
    • (2011) Nature , vol.474 , pp. 318-326
    • Medema, J.P.1    Vermeulen, L.2
  • 8
    • 77956614336 scopus 로고    scopus 로고
    • Stem cells and cancer of the stomach and intestine
    • Vries RG, Huch M, Clevers H. Stem cells and cancer of the stomach and intestine. Mol Oncol 2010;4:373-384.
    • (2010) Mol Oncol , vol.4 , pp. 373-384
    • Vries, R.G.1    Huch, M.2    Clevers, H.3
  • 9
    • 78751571234 scopus 로고    scopus 로고
    • Stem cells in colon cancer. A new era in cancer theory begins
    • Papailiou J, Bramis KJ, Gazouli M et al. Stem cells in colon cancer. A new era in cancer theory begins. Int J Colorectal Dis 2011;26:1-11.
    • (2011) Int J Colorectal Dis , vol.26 , pp. 1-11
    • Papailiou, J.1    Bramis, K.J.2    Gazouli, M.3
  • 10
    • 77951639324 scopus 로고    scopus 로고
    • Colon cancer stem cells: Promise of targeted therapy
    • Todaro M, Francipane MG, Medema JP et al. Colon cancer stem cells: Promise of targeted therapy. Gastroenterology 2010;138:2151-2162.
    • (2010) Gastroenterology , vol.138 , pp. 2151-2162
    • Todaro, M.1    Francipane, M.G.2    Medema, J.P.3
  • 11
    • 34047096557 scopus 로고    scopus 로고
    • Cancer stem cells: Models and concepts
    • DOI 10.1146/annurev.med.58.062105.204854
    • Dalerba P, Cho RW, Clarke MF. Cancer stem cells: Models and concepts. Annu Rev Med 2007;58:267-284. (Pubitemid 46706514)
    • (2007) Annual Review of Medicine , vol.58 , pp. 267-284
    • Dalerba, P.1    Cho, R.W.2    Clarke, M.F.3
  • 12
    • 79953331014 scopus 로고    scopus 로고
    • Origin and maintenance of the intestinal cancer stem cell
    • Davies EJ, Marsh V, Clarke AR. Origin and maintenance of the intestinal cancer stem cell. Mol Carcinog 2011;50:254-263.
    • (2011) Mol Carcinog , vol.50 , pp. 254-263
    • Davies, E.J.1    Marsh, V.2    Clarke, A.R.3
  • 13
    • 77958485383 scopus 로고    scopus 로고
    • Intestinal stem cell replacement follows a pattern of neutral drift
    • Lopez-Garcia C, Klein AM, Simons BD et al. Intestinal stem cell replacement follows a pattern of neutral drift. Science 2010;330:822-825.
    • (2010) Science , vol.330 , pp. 822-825
    • Lopez-Garcia, C.1    Klein, A.M.2    Simons, B.D.3
  • 14
    • 80054041585 scopus 로고    scopus 로고
    • A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable
    • Tian H, Biehs B, Warming S et al. A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable. Nature 2011;478:255-259.
    • (2011) Nature , vol.478 , pp. 255-259
    • Tian, H.1    Biehs, B.2    Warming, S.3
  • 15
    • 61349150537 scopus 로고    scopus 로고
    • Transcription factor achaete scute-like 2 controls intestinal stem cell fate
    • van der Flier LG, van Gijn ME, Hatzis P et al. Transcription factor achaete scute-like 2 controls intestinal stem cell fate. Cell 2009;136:903-912.
    • (2009) Cell , vol.136 , pp. 903-912
    • Van Der Flier, L.G.1    Van Gijn, M.E.2    Hatzis, P.3
  • 16
    • 70350444697 scopus 로고    scopus 로고
    • The stem cells of small intestinal crypts: Where are they?
    • Potten CS, Gandara R, Mahida YR et al. The stem cells of small intestinal crypts: Where are they? Cell Prolif 2009;42:731-750.
    • (2009) Cell Prolif , vol.42 , pp. 731-750
    • Potten, C.S.1    Gandara, R.2    Mahida, Y.R.3
  • 17
    • 47949105304 scopus 로고    scopus 로고
    • Colonic and colorectal cancer stem cells: Progress in the search for putative biomarkers
    • DOI 10.1111/j.1469-7580.2008.00917.x
    • Willis ND, Przyborski SA, Hutchison CJ et al. Colonic and colorectal cancer stem cells: Progress in the search for putative biomarkers. J Anat 2008;213:59-65. (Pubitemid 352044396)
    • (2008) Journal of Anatomy , vol.213 , Issue.1 , pp. 59-65
    • Willis, N.D.1    Przyborski, S.A.2    Hutchison, C.J.3    Wilson, R.G.4
  • 18
    • 62549118631 scopus 로고    scopus 로고
    • Wnt signaling, Lgr5, and stem cells in the intestine and skin
    • Haegebarth A, Clevers H. Wnt signaling, Lgr5, and stem cells in the intestine and skin. Am J Pathol 2009;174:715-721.
    • (2009) Am J Pathol , vol.174 , pp. 715-721
    • Haegebarth, A.1    Clevers, H.2
  • 19
    • 80455174708 scopus 로고    scopus 로고
    • Stem cell self-renewal in intestinal crypt
    • Simons BD, Clevers H. Stem cell self-renewal in intestinal crypt. Exp Cell Res 2011;317:2719-2724.
    • (2011) Exp Cell Res , vol.317 , pp. 2719-2724
    • Simons, B.D.1    Clevers, H.2
  • 20
    • 59049087696 scopus 로고    scopus 로고
    • Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation
    • Zhu L, Gibson P, Currle DS et al. Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation. Nature 2009;457:603-607.
    • (2009) Nature , vol.457 , pp. 603-607
    • Zhu, L.1    Gibson, P.2    Currle, D.S.3
  • 22
    • 67349123408 scopus 로고    scopus 로고
    • Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
    • Sato T, Vries RG, Snippert HJ et al. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 2009;459:262-265.
    • (2009) Nature , vol.459 , pp. 262-265
    • Sato, T.1    Vries, R.G.2    Snippert, H.J.3
  • 23
    • 65949112714 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis
    • Huang EH, Hynes MJ, Zhang T et al. Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis. Cancer Res 2009;69:3382-3389.
    • (2009) Cancer Res , vol.69 , pp. 3382-3389
    • Huang, E.H.1    Hynes, M.J.2    Zhang, T.3
  • 24
    • 74949090309 scopus 로고    scopus 로고
    • The therapeutic promise of the cancer stem cell concept
    • Frank NY, Schatton T, Frank MH. The therapeutic promise of the cancer stem cell concept. J Clin Invest 2010;120:41-50.
    • (2010) J Clin Invest , vol.120 , pp. 41-50
    • Frank, N.Y.1    Schatton, T.2    Frank, M.H.3
  • 26
    • 59049105873 scopus 로고    scopus 로고
    • Die hard: Are cancer stem cells the Bruce Willises of tumor biology?
    • Fabian A, Barok M, Vereb G et al. Die hard: Are cancer stem cells the Bruce Willises of tumor biology? Cytometry A 2009;75:67-74.
    • (2009) Cytometry A , vol.75 , pp. 67-74
    • Fabian, A.1    Barok, M.2    Vereb, G.3
  • 27
    • 77956619560 scopus 로고    scopus 로고
    • Stem cells and cancer - The promise and puzzles
    • Visvader JE, Lindeman GJ. Stem cells and cancer - The promise and puzzles. Mol Oncol 2010;4:369-372.
    • (2010) Mol Oncol , vol.4 , pp. 369-372
    • Visvader, J.E.1    Lindeman, G.J.2
  • 28
    • 52549087785 scopus 로고    scopus 로고
    • Cancer stem cells in solid tumours: Accumulating evidence and unresolved questions
    • Visvader JE, Lindeman GJ. Cancer stem cells in solid tumours: Accumulating evidence and unresolved questions. Nat Rev Cancer 2008;8:755-768.
    • (2008) Nat Rev Cancer , vol.8 , pp. 755-768
    • Visvader, J.E.1    Lindeman, G.J.2
  • 29
    • 77955051047 scopus 로고    scopus 로고
    • Prognostic impact of the expression of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and ALDH1 in colorectal cancer
    • Lugli A, Iezzi G, Hostettler I et al. Prognostic impact of the expression of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and ALDH1 in colorectal cancer. Br J Cancer 2010;103:382-390.
    • (2010) Br J Cancer , vol.103 , pp. 382-390
    • Lugli, A.1    Iezzi, G.2    Hostettler, I.3
  • 32
    • 35648969554 scopus 로고    scopus 로고
    • Wnt/beta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells
    • DOI 10.1128/MCB.01034-07
    • Fevr T, Robine S, Louvard D et al. Wnt/beta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells. Mol Cell Biol 2007;27:7551-7559. (Pubitemid 350033660)
    • (2007) Molecular and Cellular Biology , vol.27 , Issue.21 , pp. 7551-7559
    • Fevr, T.1    Robine, S.2    Louvard, D.3    Huelsken, J.4
  • 33
    • 52549113913 scopus 로고    scopus 로고
    • Bone morphogenetic protein signalling in colorectal cancer
    • Hardwick JC, Kodach LL, Offerhaus GJ et al. Bone morphogenetic protein signalling in colorectal cancer. Nat Rev Cancer 2008;8:806-812.
    • (2008) Nat Rev Cancer , vol.8 , pp. 806-812
    • Hardwick, J.C.1    Kodach, L.L.2    Offerhaus, G.J.3
  • 34
    • 2442702670 scopus 로고    scopus 로고
    • Stem cell in gastrointestinal structure and neoplastic development
    • DOI 10.1136/gut.2003.025478
    • Brittan M, Wright NA. Stem cell in gastrointestinal structure and neoplastic development. Gut 2004;53:899-910. (Pubitemid 38662143)
    • (2004) Gut , vol.53 , Issue.6 , pp. 899-910
    • Brittan, M.1    Wright, N.A.2
  • 35
    • 77953782543 scopus 로고    scopus 로고
    • The stem cell niche in health and malignancy
    • Burness ML, Sipkins DA. The stem cell niche in health and malignancy. Semin Cancer Biol 2010;20:107-115.
    • (2010) Semin Cancer Biol , vol.20 , pp. 107-115
    • Burness, M.L.1    Sipkins, D.A.2
  • 36
    • 77951975325 scopus 로고    scopus 로고
    • Wnt activity defines colon cancer stem cells and is regulated by the microenvironment
    • Vermeulen L, De Sousa EMF, van der Heijden M et al. Wnt activity defines colon cancer stem cells and is regulated by the microenvironment. Nat Cell Biol 2010;12:468-476.
    • (2010) Nat Cell Biol , vol.12 , pp. 468-476
    • Vermeulen, L.1    De Sousa, E.M.F.2    Van Der Heijden, M.3
  • 37
    • 77950591041 scopus 로고    scopus 로고
    • Cancer stemness and metastasis: Therapeutic consequences and perspectives
    • Monteiro J, Fodde R. Cancer stemness and metastasis: Therapeutic consequences and perspectives. Eur J Cancer 2010;46:1198-1203.
    • (2010) Eur J Cancer , vol.46 , pp. 1198-1203
    • Monteiro, J.1    Fodde, R.2
  • 38
    • 0032489508 scopus 로고    scopus 로고
    • Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes
    • DOI 10.1016/S0092-8674(00)81132-0
    • Takaku K, Oshima M, Miyoshi H et al. Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes. Cell 1998;92:645-656. (Pubitemid 28141513)
    • (1998) Cell , vol.92 , Issue.5 , pp. 645-656
    • Takaku, K.1    Oshima, M.2    Miyoshi, H.3    Matsui, M.4    Seldin, M.F.5    Taketo, M.M.6
  • 39
    • 12344318372 scopus 로고    scopus 로고
    • Context, tissue plasticity, and cancer: Are tumor stem cells also regulated by the microenvironment?
    • DOI 10.1016/j.ccr.2004.12.013, PII S1535610804003757
    • Bissell MJ, Labarge MA. Context, tissue plasticity, and cancer: Are tumor stem cells also regulated by the microenvironment? Cancer Cell 2005;7:17-23. (Pubitemid 40126379)
    • (2005) Cancer Cell , vol.7 , Issue.1 , pp. 17-23
    • Bissell, M.J.1    Labarge, M.A.2
  • 40
    • 79953147370 scopus 로고    scopus 로고
    • A perspective on cancer cell metastasis
    • Chaffer CL, Weinberg RA. A perspective on cancer cell metastasis. Science 2011;331:1559-1564.
    • (2011) Science , vol.331 , pp. 1559-1564
    • Chaffer, C.L.1    Weinberg, R.A.2
  • 41
    • 79953301542 scopus 로고    scopus 로고
    • Do all roads lead to Rome? Routes to metastasis development
    • Sleeman JP, Nazarenko I, Thiele W. Do all roads lead to Rome? Routes to metastasis development. Int J Cancer 2011;128:2511-2526.
    • (2011) Int J Cancer , vol.128 , pp. 2511-2526
    • Sleeman, J.P.1    Nazarenko, I.2    Thiele, W.3
  • 42
    • 38849161579 scopus 로고    scopus 로고
    • Adhesion molecules and chemokines: The navigation system for circulating tumor (stem) cells to metastasize in an organ-specific manner
    • DOI 10.1007/s10585-007-9095-5
    • Dittmar T, Heyder C, Gloria-Maercker E et al. Adhesion molecules and chemokines: The navigation system for circulating tumor (stem) cells to metastasize in an organ-specific manner. Clin Exp Metastasis 2008;25:11-32. (Pubitemid 351191223)
    • (2008) Clinical and Experimental Metastasis , vol.25 , Issue.1 , pp. 11-32
    • Dittmar, T.1    Heyder, C.2    Gloria-Maercker, E.3    Hatzmann, W.4    Zanker, K.S.5
  • 44
    • 77956178360 scopus 로고    scopus 로고
    • EMT, cancer stem cells and drug resistance: An emerging axis of evil in the war on cancer
    • Singh A, Settleman J. EMT, cancer stem cells and drug resistance: An emerging axis of evil in the war on cancer. Oncogene 2010;29:4741-4751.
    • (2010) Oncogene , vol.29 , pp. 4741-4751
    • Singh, A.1    Settleman, J.2
  • 45
    • 79953689605 scopus 로고    scopus 로고
    • Cancer stem cells and epithelial-to-mesenchymal transition (EMT)-phenotypic cells: Are they cousins or twins?
    • Basel
    • Kong D, Li Y, Wang Z et al. Cancer stem cells and epithelial-to- mesenchymal transition (EMT)-phenotypic cells: Are they cousins or twins? Cancers (Basel) 2011;3:716-729.
    • (2011) Cancers , vol.3 , pp. 716-729
    • Kong, D.1    Li, Y.2    Wang, Z.3
  • 46
    • 34548428724 scopus 로고    scopus 로고
    • Cancer Stem Cells and Tumor Metastasis: First Steps into Uncharted Territory
    • DOI 10.1016/j.stem.2007.08.012, PII S1934590907001312
    • Dalerba P, Clarke MF. Cancer stem cells and tumor metastasis: First steps into uncharted territory. Cell Stem Cell 2007;1:241-242. (Pubitemid 47355332)
    • (2007) Cell Stem Cell , vol.1 , Issue.3 , pp. 241-242
    • Dalerba, P.1    Clarke, M.F.2
  • 47
    • 69949129056 scopus 로고    scopus 로고
    • Cancer stem cells: Mirage or reality?
    • Gupta PB, Chaffer CL, Weinberg RA. Cancer stem cells: Mirage or reality? Nat Med 2009;15:1010-1012.
    • (2009) Nat Med , vol.15 , pp. 1010-1012
    • Gupta, P.B.1    Chaffer, C.L.2    Weinberg, R.A.3
  • 48
    • 67649939163 scopus 로고    scopus 로고
    • The increasing complexity of the cancer stem cell paradigm
    • Rosen JM, Jordan CT. The increasing complexity of the cancer stem cell paradigm. Science 2009;324:1670-1673.
    • (2009) Science , vol.324 , pp. 1670-1673
    • Rosen, J.M.1    Jordan, C.T.2
  • 49
    • 79953901990 scopus 로고    scopus 로고
    • Molecular mechanisms of metastasis
    • Hoon DS, Ferris R, Tanaka R et al. Molecular mechanisms of metastasis. J Surg Oncol 2011;103:508-517.
    • (2011) J Surg Oncol , vol.103 , pp. 508-517
    • Hoon, D.S.1    Ferris, R.2    Tanaka, R.3
  • 50
    • 79961170499 scopus 로고    scopus 로고
    • Circulating tumor cells: Advances in detection methods, biological issues, and clinical relevance
    • Sun YF, Yang XR, Zhou J et al. Circulating tumor cells: Advances in detection methods, biological issues, and clinical relevance. J Cancer Res Clin Oncol 2011;137:1151-1173.
    • (2011) J Cancer Res Clin Oncol , vol.137 , pp. 1151-1173
    • Sun, Y.F.1    Yang, X.R.2    Zhou, J.3
  • 51
    • 79955030814 scopus 로고    scopus 로고
    • Clinical significance of circulating tumor cells, including cancer stem-like cells, in peripheral blood for recurrence and prognosis in patients with Dukes' stage B and C colorectal cancer
    • Iinuma H, Watanabe T, Mimori K et al. Clinical significance of circulating tumor cells, including cancer stem-like cells, in peripheral blood for recurrence and prognosis in patients with Dukes' stage B and C colorectal cancer. J Clin Oncol 2011;29:1547-1555.
    • (2011) J Clin Oncol , vol.29 , pp. 1547-1555
    • Iinuma, H.1    Watanabe, T.2    Mimori, K.3
  • 52
    • 77957119596 scopus 로고    scopus 로고
    • Molecular markers in circulating tumour cells from metastatic colorectal cancer patients
    • Gazzaniga P, Gradilone A, Petracca A et al. Molecular markers in circulating tumour cells from metastatic colorectal cancer patients. J Cell Mol Med 2010;14:2073-2077.
    • (2010) J Cell Mol Med , vol.14 , pp. 2073-2077
    • Gazzaniga, P.1    Gradilone, A.2    Petracca, A.3
  • 53
    • 70350498771 scopus 로고    scopus 로고
    • Colorectal cancer stem cells
    • Salama P, Platell C. Colorectal cancer stem cells. ANZ J Surg 2009;79:697-702.
    • (2009) ANZ J Surg , vol.79 , pp. 697-702
    • Salama, P.1    Platell, C.2
  • 54
    • 38349074508 scopus 로고    scopus 로고
    • The 5th International Society for Stem Cell Research (ISSCR) Annual Meeting, June 2007
    • Rajasekhar VK, Dalerba P, Passegue E et al. The 5th International Society for Stem Cell Research (ISSCR) Annual Meeting, June 2007. Stem Cells 2008;26:292-298.
    • (2008) Stem Cells , vol.26 , pp. 292-298
    • Rajasekhar, V.K.1    Dalerba, P.2    Passegue, E.3
  • 55
    • 63049115530 scopus 로고    scopus 로고
    • Phenotypic subpopulations of metastatic colon cancer stem cells: Genomic analysis
    • Botchkina IL, Rowehl RA, Rivadeneira DE et al. Phenotypic subpopulations of metastatic colon cancer stem cells: Genomic analysis. Cancer Genomics Proteomics 2009;6:19-29.
    • (2009) Cancer Genomics Proteomics , vol.6 , pp. 19-29
    • Botchkina, I.L.1    Rowehl, R.A.2    Rivadeneira, D.E.3
  • 57
    • 77954646313 scopus 로고    scopus 로고
    • Emerging strategies for the identification and targeting of cancer stem cells
    • Dou J, Gu N. Emerging strategies for the identification and targeting of cancer stem cells. Tumour Biol 2010;31:243-253.
    • (2010) Tumour Biol , vol.31 , pp. 243-253
    • Dou, J.1    Gu, N.2
  • 59
    • 33846100356 scopus 로고    scopus 로고
    • A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
    • DOI 10.1038/nature05372, PII NATURE05372
    • O'Brien CA, Pollett A, Gallinger S et al. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 2007;445:106-110. (Pubitemid 46067310)
    • (2007) Nature , vol.445 , Issue.7123 , pp. 106-110
    • O'Brien, C.A.1    Pollett, A.2    Gallinger, S.3    Dick, J.E.4
  • 60
    • 53849134099 scopus 로고    scopus 로고
    • CD133 expression is an independent prognostic marker for low survival in colorectal cancer
    • Horst D, Kriegl L, Engel J et al. CD133 expression is an independent prognostic marker for low survival in colorectal cancer. Br J Cancer 2008;99:1285-1289.
    • (2008) Br J Cancer , vol.99 , pp. 1285-1289
    • Horst, D.1    Kriegl, L.2    Engel, J.3
  • 61
    • 67649359505 scopus 로고    scopus 로고
    • CD133 and nuclear beta-catenin: The marker combination to detect high risk cases of low stage colorectal cancer
    • Horst D, Kriegl L, Engel J et al. CD133 and nuclear beta-catenin: The marker combination to detect high risk cases of low stage colorectal cancer. Eur J Cancer 2009;45:2034-2040.
    • (2009) Eur J Cancer , vol.45 , pp. 2034-2040
    • Horst, D.1    Kriegl, L.2    Engel, J.3
  • 62
    • 49749109053 scopus 로고    scopus 로고
    • Immunohistochemical detection of CD133 expression in colorectal cancer: A clinicopathological study
    • Kojima M, Ishii G, Atsumi N et al. Immunohistochemical detection of CD133 expression in colorectal cancer: A clinicopathological study. Cancer Sci 2008;99:1578-1583.
    • (2008) Cancer Sci , vol.99 , pp. 1578-1583
    • Kojima, M.1    Ishii, G.2    Atsumi, N.3
  • 63
    • 72249120793 scopus 로고    scopus 로고
    • The cancer stem cell marker CD133 has high prognostic impact but unknown functional relevance for the metastasis of human colon cancer
    • Horst D, Scheel SK, Liebmann S et al. The cancer stem cell marker CD133 has high prognostic impact but unknown functional relevance for the metastasis of human colon cancer. J Pathol 2009;219:427-434.
    • (2009) J Pathol , vol.219 , pp. 427-434
    • Horst, D.1    Scheel, S.K.2    Liebmann, S.3
  • 64
    • 75449109041 scopus 로고    scopus 로고
    • Tumour CD133 mRNA expression and clinical outcome in surgically resected colorectal cancer patients
    • Artells R, Moreno I, Diaz T et al. Tumour CD133 mRNA expression and clinical outcome in surgically resected colorectal cancer patients. Eur J Cancer 2010;46:642-649.
    • (2010) Eur J Cancer , vol.46 , pp. 642-649
    • Artells, R.1    Moreno, I.2    Diaz, T.3
  • 65
    • 78649669323 scopus 로고    scopus 로고
    • CD133 mRNA expression and microsatellite instability in colorectal carcinoma
    • Huh JW, Park YS, Lee JH et al. CD133 mRNA expression and microsatellite instability in colorectal carcinoma. J Surg Oncol 2010;102:765-770.
    • (2010) J Surg Oncol , vol.102 , pp. 765-770
    • Huh, J.W.1    Park, Y.S.2    Lee, J.H.3
  • 66
    • 69549107752 scopus 로고    scopus 로고
    • Cancer stem cell marker CD133+ tumour cells and clinical outcome in rectal cancer
    • Wang Q, Chen ZG, Du CZ et al. Cancer stem cell marker CD133+ tumour cells and clinical outcome in rectal cancer. Histopathology 2009;55:284-293.
    • (2009) Histopathology , vol.55 , pp. 284-293
    • Wang, Q.1    Chen, Z.G.2    Du, C.Z.3
  • 67
    • 77956519347 scopus 로고    scopus 로고
    • The stem cell marker CD133 associates with enhanced colony formation and cell motility in colorectal cancer
    • Elsaba TM, Martinez-Pomares L, Robins AR et al. The stem cell marker CD133 associates with enhanced colony formation and cell motility in colorectal cancer. PLoS One 2010;19:e10714.
    • (2010) PLoS One , vol.19
    • Elsaba, T.M.1    Martinez-Pomares, L.2    Robins, A.R.3
  • 68
    • 76549120193 scopus 로고    scopus 로고
    • The AC133 epitope, but not the CD133 protein, is lost upon cancer stem cell differentiation
    • Kemper K, Sprick MR, de Bree M et al. The AC133 epitope, but not the CD133 protein, is lost upon cancer stem cell differentiation. Cancer Res 2010;70:719-729.
    • (2010) Cancer Res , vol.70 , pp. 719-729
    • Kemper, K.1    Sprick, M.R.2    De Bree, M.3
  • 69
    • 77952788085 scopus 로고    scopus 로고
    • Glioblastoma cells negative for the anti-CD133 antibody AC133 express a truncated variant of the CD133 protein
    • Osmond TL, Broadley KW, McConnell MJ. Glioblastoma cells negative for the anti-CD133 antibody AC133 express a truncated variant of the CD133 protein. Int J Mol Med 2010;5:883-888.
    • (2010) Int J Mol Med , vol.5 , pp. 883-888
    • Osmond, T.L.1    Broadley, K.W.2    McConnell, M.J.3
  • 71
    • 58149269566 scopus 로고    scopus 로고
    • CD44 is of functional importance for colorectal cancer stem cells
    • Du L, Wang H, He L et al. CD44 is of functional importance for colorectal cancer stem cells. Clin Cancer Res 2008;14:6751-6760.
    • (2008) Clin Cancer Res , vol.14 , pp. 6751-6760
    • Du, L.1    Wang, H.2    He, L.3
  • 72
    • 63849268405 scopus 로고    scopus 로고
    • Expression of standard CD44 in human colorectal carcinoma: Association with prognosis
    • Huh JW, Kim HR, Kim YJ et al. Expression of standard CD44 in human colorectal carcinoma: Association with prognosis. Pathol Int 2009;59:241-246.
    • (2009) Pathol Int , vol.59 , pp. 241-246
    • Huh, J.W.1    Kim, H.R.2    Kim, Y.J.3
  • 73
    • 51649099207 scopus 로고    scopus 로고
    • CD133+CD44+ population efficiently enriches colon cancer initiating cells
    • Haraguchi N, Ohkuma M, Sakashita H et al. CD133+CD44+ population efficiently enriches colon cancer initiating cells. Ann Surg Oncol 2008;15:2927-2933.
    • (2008) Ann Surg Oncol , vol.15 , pp. 2927-2933
    • Haraguchi, N.1    Ohkuma, M.2    Sakashita, H.3
  • 75
    • 60549106250 scopus 로고    scopus 로고
    • Characterization of a subpopulation of colon cancer cells with stem cell-like properties
    • Chu P, Clanton DJ, Snipas TS et al. Characterization of a subpopulation of colon cancer cells with stem cell-like properties. Int J Cancer 2009;124:1312-1321.
    • (2009) Int J Cancer , vol.124 , pp. 1312-1321
    • Chu, P.1    Clanton, D.J.2    Snipas, T.S.3
  • 76
  • 77
    • 51649111430 scopus 로고    scopus 로고
    • Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity
    • Vermeulen L, Todaro M, de Sousa Mello F et al. Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity. Proc Natl Acad Sci USA 2008;105:13427-13432.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 13427-13432
    • Vermeulen, L.1    Todaro, M.2    De Sousa Mello, F.3
  • 78
    • 67650138937 scopus 로고    scopus 로고
    • Cancer stem cell markers CD133 and CD24 correlate with invasiveness and differentiation in colorectal adenocarcinoma
    • Choi D, Lee HW, Hur KY et al. Cancer stem cell markers CD133 and CD24 correlate with invasiveness and differentiation in colorectal adenocarcinoma. World J Gastroenterol 2009;15:2258-2264.
    • (2009) World J Gastroenterol , vol.15 , pp. 2258-2264
    • Choi, D.1    Lee, H.W.2    Hur, K.Y.3
  • 80
    • 77649257052 scopus 로고    scopus 로고
    • Cancer stem cells from colorectal cancer-derived cell lines
    • Yeung TM, Gandhi SC, Wilding JL et al. Cancer stem cells from colorectal cancer-derived cell lines. Proc Natl Acad Sci USA 2010;107:3722-3727.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 3722-3727
    • Yeung, T.M.1    Gandhi, S.C.2    Wilding, J.L.3
  • 81
    • 72349088959 scopus 로고    scopus 로고
    • Expression of putative stem cell genes Musashi-1 and beta1-integrin in human colorectal adenomas and adenocarcinomas
    • Fan LF, Dong WG, Jiang CQ et al. Expression of putative stem cell genes Musashi-1 and beta1-integrin in human colorectal adenomas and adenocarcinomas. Int J Colorectal Dis 2010;25:17-23.
    • (2010) Int J Colorectal Dis , vol.25 , pp. 17-23
    • Fan, L.F.1    Dong, W.G.2    Jiang, C.Q.3
  • 82
    • 8444241199 scopus 로고    scopus 로고
    • ALCAM/CD166 is overexpressed in colorectal carcinoma and correlates with shortened patient survival
    • DOI 10.1136/jcp.2004.016238
    • Weichert W, Knosel T, Bellach J et al. ALCAM/CD166 is overexpressed in colorectal carcinoma and correlates with shortened patient survival. J Clin Pathol 2004;57:1160-1164. (Pubitemid 39486521)
    • (2004) Journal of Clinical Pathology , vol.57 , Issue.11 , pp. 1160-1164
    • Weichert, W.1    Knosel, T.2    Bellach, J.3    Dietel, M.4    Kristiansen, G.5
  • 83
    • 56749091913 scopus 로고    scopus 로고
    • Immunostaining of Lgr5, an intestinal stem cell marker, in normal and premalignant human gastrointestinal tissue
    • Becker L, Huang Q, Mashimo H. Immunostaining of Lgr5, an intestinal stem cell marker, in normal and premalignant human gastrointestinal tissue. ScientificWorldJournal 2008;8:1168-1176.
    • (2008) ScientificWorldJournal , vol.8 , pp. 1168-1176
    • Becker, L.1    Huang, Q.2    Mashimo, H.3
  • 84
    • 59049106578 scopus 로고    scopus 로고
    • Crypt stem cells as the cells-of-origin of intestinal cancer
    • Barker N, Ridgway RA, van Es JH et al. Crypt stem cells as the cells-of-origin of intestinal cancer. Nature 2009;457:608-611.
    • (2009) Nature , vol.457 , pp. 608-611
    • Barker, N.1    Ridgway, R.A.2    Van Es, J.H.3
  • 85
    • 80051603461 scopus 로고    scopus 로고
    • Expression of the adult intestinal stem cell marker Lgr5 in the metastatic cascade of colorectal cancer
    • Kleist B, Xu L, Li G et al. Expression of the adult intestinal stem cell marker Lgr5 in the metastatic cascade of colorectal cancer. Int J Clin Exp Pathol 2011;4:327-335.
    • (2011) Int J Clin Exp Pathol , vol.4 , pp. 327-335
    • Kleist, B.1    Xu, L.2    Li, G.3
  • 86
    • 79955800644 scopus 로고    scopus 로고
    • Significance of Lgr5(+ve) cancer stem cells in the colon and rectum
    • Takahashi H, Ishii H, Nishida N et al. Significance of Lgr5(+ve) cancer stem cells in the colon and rectum. Ann Surg Oncol 2011;18:1166-1174.
    • (2011) Ann Surg Oncol , vol.18 , pp. 1166-1174
    • Takahashi, H.1    Ishii, H.2    Nishida, N.3
  • 87
    • 77956641496 scopus 로고    scopus 로고
    • A subpopulation of CD26+ cancer stem cells with metastatic capacity in human colorectal cancer
    • Pang R, Law WL, Chu AC et al. A subpopulation of CD26+ cancer stem cells with metastatic capacity in human colorectal cancer. Cell Stem Cell 2010;6:603-615.
    • (2010) Cell Stem Cell , vol.6 , pp. 603-615
    • Pang, R.1    Law, W.L.2    Chu, A.C.3
  • 88
    • 79651473122 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase 1B1 (ALDH1B1) is a potential biomarker for human colon cancer
    • Chen Y, Orlicky DJ, Matsumoto A et al. Aldehyde dehydrogenase 1B1 (ALDH1B1) is a potential biomarker for human colon cancer. Biochem Biophys Res Commun 2011;405:173-179.
    • (2011) Biochem Biophys Res Commun , vol.405 , pp. 173-179
    • Chen, Y.1    Orlicky, D.J.2    Matsumoto, A.3
  • 89
    • 77956302698 scopus 로고    scopus 로고
    • Distinct expression levels and patterns of stem cell marker, aldehyde dehydrogenase isoform 1 (ALDH1), in human epithelial cancers
    • Deng S, Yang X, Lassus H et al. Distinct expression levels and patterns of stem cell marker, aldehyde dehydrogenase isoform 1 (ALDH1), in human epithelial cancers. PLoS One 2010;5:e10277.
    • (2010) PLoS One , vol.5
    • Deng, S.1    Yang, X.2    Lassus, H.3
  • 90
    • 70350247558 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase-expressing colon stem cells contribute to tumorigenesis in the transition from colitis to cancer
    • Carpentino JE, Hynes MJ, Appelman HD et al. Aldehyde dehydrogenase- expressing colon stem cells contribute to tumorigenesis in the transition from colitis to cancer. Cancer Res 2009;69:8208-8215.
    • (2009) Cancer Res , vol.69 , pp. 8208-8215
    • Carpentino, J.E.1    Hynes, M.J.2    Appelman, H.D.3
  • 91
    • 68949218780 scopus 로고    scopus 로고
    • Comprehensive analysis of the clinical significance of inducing pluripotent stemness-related gene expression in colorectal cancer cells
    • Saiki Y, Ishimaru S, Mimori K et al. Comprehensive analysis of the clinical significance of inducing pluripotent stemness-related gene expression in colorectal cancer cells. Ann Surg Oncol 2009;16:2638-2644.
    • (2009) Ann Surg Oncol , vol.16 , pp. 2638-2644
    • Saiki, Y.1    Ishimaru, S.2    Mimori, K.3
  • 92
    • 77649272778 scopus 로고    scopus 로고
    • CD133 expression predicts for non-response to chemotherapy in colorectal cancer
    • Ong CW, Kim LG, Kong HH et al. CD133 expression predicts for non-response to chemotherapy in colorectal cancer. Mod Pathol 2010;23:450-457.
    • (2010) Mod Pathol , vol.23 , pp. 450-457
    • Ong, C.W.1    Kim, L.G.2    Kong, H.H.3
  • 93
    • 71549155909 scopus 로고    scopus 로고
    • Correlation of CD133, OCT4, and SOX2 in rectal cancer and their association with distant recurrence after chemoradiotherapy
    • Saigusa S, Tanaka K, Toiyama Y et al. Correlation of CD133, OCT4, and SOX2 in rectal cancer and their association with distant recurrence after chemoradiotherapy. Ann Surg Oncol 2009;16:3488-3498.
    • (2009) Ann Surg Oncol , vol.16 , pp. 3488-3498
    • Saigusa, S.1    Tanaka, K.2    Toiyama, Y.3
  • 94
    • 77958537327 scopus 로고    scopus 로고
    • Isolation and propagation of a human CD133(-) colon tumor-derived cell line with tumorigenic and angiogenic properties
    • Navarro-Alvarez N, Kondo E, Kawamoto H et al. Isolation and propagation of a human CD133(-) colon tumor-derived cell line with tumorigenic and angiogenic properties. Cell Transplant 2010;19:865-877.
    • (2010) Cell Transplant , vol.19 , pp. 865-877
    • Navarro-Alvarez, N.1    Kondo, E.2    Kawamoto, H.3
  • 95
    • 33750584024 scopus 로고    scopus 로고
    • Tumour stem cell-targeted treatment: Elimination or differentiation
    • DOI 10.1093/annonc/mdl074
    • Massard C, Deutsch E, Soria JC. Tumour stem cell-targeted treatment: Elimination or differentiation. Ann Oncol 2006;17:1620-1624. (Pubitemid 44680880)
    • (2006) Annals of Oncology , vol.17 , Issue.11 , pp. 1620-1624
    • Massard, C.1    Deutsch, E.2    Soria, J.-C.3
  • 96
    • 49149107236 scopus 로고    scopus 로고
    • Colorectal cancer stem cells are enriched in xenogeneic tumors following chemotherapy
    • Dylla SJ, Beviglia L, Park IK et al. Colorectal cancer stem cells are enriched in xenogeneic tumors following chemotherapy. PLoS One 2008;3:e2428.
    • (2008) PLoS One , vol.3
    • Dylla, S.J.1    Beviglia, L.2    Park, I.K.3
  • 97
    • 70349547152 scopus 로고    scopus 로고
    • Identification and targeting of cancer stem cells
    • Schatton T, Frank NY, Frank MH. Identification and targeting of cancer stem cells. Bioessays 2009;31:1038-1049.
    • (2009) Bioessays , vol.31 , pp. 1038-1049
    • Schatton, T.1    Frank, N.Y.2    Frank, M.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.