Targeting of DNA Damage Signaling Pathway Induced Senescence and Reduced Migration of Cancer cells

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 70, Issue 6, 2015, Pages 701-713

  Gao, Ran ^a   Singh, Rumani ^a   Kaul, Zeenia ^a,b   Kaul, Sunil C ^a   Wadhwa, Renu ^a  

^a NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^b THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Bioinformatics; Cancer; DNA damage pathway; Growth arrest; Induced senescence; Mortalin staining pattern; p16INK4A; shRNA screening

Indexed keywords

BRAP PROTEIN, HUMAN; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; DNA BINDING PROTEIN; DOUBLE STRANDED RNA; HEAT SHOCK PROTEIN 70; KARYOPHERIN ALPHA; KPNA2 PROTEIN, HUMAN; MRE11A PROTEIN, HUMAN; NBN PROTEIN, HUMAN; NUCLEAR PROTEIN; TELOMERE BINDING PROTEIN; TINF2 PROTEIN, HUMAN; UBIQUITIN PROTEIN LIGASE;

CELL AGING; CELL MOTION; DNA DAMAGE; GENE LIBRARY; GENETICS; HUMAN; METABOLISM; NEOPLASM; PATHOLOGY; TUMOR CELL LINE;

ALPHA KARYOPHERINS; CELL AGING; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL MOVEMENT; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA DAMAGE; DNA-BINDING PROTEINS; GENE LIBRARY; HSP70 HEAT-SHOCK PROTEINS; HUMANS; NEOPLASMS; NUCLEAR PROTEINS; RNA, DOUBLE-STRANDED; TELOMERE-BINDING PROTEINS; UBIQUITIN-PROTEIN LIGASES;

EID: 84937546475     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glu019     Document Type: Article

References (55)

1. Hayflick L, Moorhead PS. The serial cultivation of human diploid cell strains. Exp Cell Res. 1961;25:585-621.
2. Campisi J. Aging and cancer: The double-edged sword of replicative senescence. J Am Geriatr Soc. 1997;45:482-488.
3. Reddel RR. The role of senescence and immortalization in carcinogenesis. Carcinogenesis. 2000;21:477-484.
4. Prieur A, Peeper DS. Cellular senescence in vivo: A barrier to tumorigenesis. Curr Opin Cell Biol. 2008;20:150-155. doi:10.1016/j.ceb.2008.01.007
5. Duncan EL, Wadhwa R, Kaul SC. Senescence and immortalization of human cells. Biogerontology. 2000;1:103-121.
6. Campisi J. Between Scylla and Charybdis: P53 links tumor suppression and aging. Mech Ageing Dev. 2002;123:567-573.
7. Campisi J. Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors. Cell. 2005;120:513-522.
8. Lleonart ME, Artero-Castro A, Kondoh H. Senescence induction; a possible cancer therapy. Mol Cancer. 2009;8:3. doi:10.1186/1476-4598-8-3
9. Kaul SC, Deocaris CC, Wadhwa R. Three faces of mortalin: A housekeeper, guardian and killer. Exp Gerontol. 2007;42:263-274.
10. Wadhwa R, Takano S, Robert M, et al. Inactivation of tumor suppressor p53 by mot-2, a hsp70 family member. J Biol Chem. 1998;273:29586-29591.
11. Kaul SC, Aida S, Yaguchi T, Kaur K, Wadhwa R. Activation of wild type p53 function by its mortalin-binding, cytoplasmically localizing carboxyl terminus peptides. J Biol Chem. 2005;280:39373-39379.
12. Ma Z, Izumi H, Kanai M, Kabuyama Y, Ahn NG, Fukasawa K. Mortalin controls centrosome duplication via modulating centrosomal localization of p53. Oncogene. 2006;25:5377-5390.
13. Wadhwa R, Takano S, Kaur K, et al. Upregulation of mortalin/mthsp70/Grp75 contributes to human carcinogenesis. Int J Cancer. 2006;118:2973-2980.
14. Dundas SR, Lawrie LC, Rooney PH, Murray GI. Mortalin is overexpressed by colorectal adenocarcinomas and correlates with poor survival. J Pathol. 2005;205:74-81.
15. Yi X, Luk JM, Lee NP, et al. Association of mortalin (HSPA9) with liver cancer metastasis and prediction for early tumor recurrence. Mol Cell Proteomics. 2008;7:315-325.
16. Lu WJ, Lee NP, Kaul SC, et al. Mortalin-p53 interaction in cancer cells is stress dependent and constitutes a selective target for cancer therapy. Cell Death Differ. 2011;18:1046-1056. doi:10.1038/cdd.2010.177
17. Wadhwa R, Kaul SC, Mitsui Y, Sugimoto Y. Differential subcellular distribution of mortalin in mortal and immortal mouse and human fibroblasts. Exp Cell Res. 1993;207:442-448.
18. Wadhwa R, Sugihara T, Yoshida A, et al. Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function. Cancer Res. 2000;60:6818-6821.
19. Michishita E, Nakabayashi K, Suzuki T, et al. 5-Bromodeoxyuridine induces senescence-like phenomena in mammalian cells regardless of cell type or species. J Biochem. 1999;126:1052-1059.
20. Widodo N, Deocaris CC, Kaur K, et al. Stress chaperones, mortalin, and pex19p mediate 5-aza-2' deoxycytidine-induced senescence of cancer cells by DNA methylation-independent pathway. J Gerontol A Biol Sci Med Sci. 2007;62:246-255.
21. Widodo N, Takagi Y, Shrestha BG, Ishii T, Kaul SC, Wadhwa R. Selective killing of cancer cells by leaf extract of Ashwagandha: Components, activity and pathway analyses. Cancer Lett. 2008;262:37-47. doi:10.1016/j. canlet.2007.11.037
22. Kaul Z, Yaguchi T, Chiura HX, Kaul SC, Wadhwa R. Quantum dot-based mortalin staining as a visual assay for detection of induced senescence in cancer cells. Ann N Y Acad Sci. 2007;1100:368-372.
23. Gao R, Yaguchi T, Horimoto K, et al. Identification of anti-cancer shRNAs based on the staining pattern of mortalin. Tiss Cult Res Commun. 2010;29:147-153.
24. Wadhwa R, Kaul SC, Ikawa Y, Sugimoto Y. Identification of a novel member of mouse hsp70 family. Its association with cellular mortal phenotype. J Biol Chem. 1993;268:6615-6621.
25. Saito S, Morita K, Hirano T. High frequency of common DNA copy number abnormalities detected by bacterial artificial chromosome array comparative genomic hybridization in 24 breast cancer cell lines. Hum Cell. 2009;22:1-10. doi:10.1111/j.1749-0774.2008.00061.x
26. Saito S, Ghosh M, Morita K, Hirano T, Miwa M, Todoroki T. The genetic differences between gallbladder and bile duct cancer cell lines. Oncol Rep. 2006;16:949-956.
27. Hasan K, Cheung C, Kaul Z, et al. CARF Is a vital dual regulator of cellular senescence and apoptosis. J Biol Chem. 2009;284:1664-1672. doi:10.1074/jbc.M805778200
28. Bertram MJ, Bérubé NG, Hang-Swanson X, et al. Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes. Mol Cell Biol. 1999;19:1479-1485.
29. De Siervi A, De Luca P, Byun JS, et al. Transcriptional autoregulation by BRCA1. Cancer Res. 2010;70:532-542. doi:10.1158/0008-5472.CAN-09-1477
30. Deng R, Tang J, Ma JG, et al. PKB/Akt promotes DSB repair in cancer cells through upregulating Mre11 expression following ionizing radiation. Oncogene. 2011;30:944-955. doi:10.1038/onc.2010.467
31. Kobayashi J, Antoccia A, Tauchi H, Matsuura S, Komatsu K. NBS1 and its functional role in the DNA damage response. DNA Repair (Amst). 2004;3:855-861.
32. van den Bosch M, Bree RT, Lowndes NF. The MRN complex: Coordinating and mediating the response to broken chromosomes. EMBO Rep. 2003;4:844-849.
33. Teng SC, Wu KJ, Tseng SF, Wong CW, Kao L. Importin KPNA2, NBS1, DNA repair and tumorigenesis. J Mol Histol. 2006;37:293-299.
34. Sun Y, Jiang X, Price BD. Tip60: Connecting chromatin to DNA damage signaling. Cell Cycle. 2010;9:930-936.
35. Yang MH, Chang SY, Chiou SH, et al. Overexpression of NBS1 induces epithelial-mesenchymal transition and co-expression of NBS1 and Snail predicts metastasis of head and neck cancer. Oncogene. 2007;26:1459-1467.
36. Zhong ZH, Jiang WQ, Cesare AJ, Neumann AA, Wadhwa R, Reddel RR. Disruption of telomere maintenance by depletion of the MRE11/RAD50/NBS1 complex in cells that use alternative lengthening of telomeres. J Biol Chem. 2007;282:29314-29322.
37. Oh BK, Kim YJ, Park C, Park YN. Up-regulation of telomere-binding proteins, TRF1, TRF2, and TIN2 is related to telomere shortening during human multistep hepatocarcinogenesis. Am J Pathol. 2005;166:73-80.
38. Jensen JB, Munksgaard PP, Sørensen CM, et al. High expression of karyopherin-?2 defines poor prognosis in non-muscle-invasive bladder cancer and in patients with invasive bladder cancer undergoing radical cystectomy. Eur Urol. 2011;59:841-848. doi:10.1016/j.eururo.2011.01.048
39. Zheng M, Tang L, Huang L, et al. Overexpression of karyopherin-2 in epithelial ovarian cancer and correlation with poor prognosis. Obstet Gynecol. 2010;116:884-891. doi:10.1097/AOG.0b013e3181f104ce
40. Wang CI, Wang CL, Wang CW, et al. Importin subunit alpha-2 is identified as a potential biomarker for non-small cell lung cancer by integration of the cancer cell secretome and tissue transcriptome. Int J Cancer. 2011;128:2364-2372. doi:10.1002/ijc.25568
41. Dickey JS, Redon CE, Nakamura AJ, Baird BJ, Sedelnikova OA, Bonner WM. H2AX: Functional roles and potential applications. Chromosoma. 2009;118:683-692. doi:10.1007/s00412-009-0234-4
42. Cheung CT, Singh R, Yoon AR, et al. Molecular characterization of apoptosis induced by CARF silencing in human cancer cells. Cell Death Differ. 2011;18:589-601. doi:10.1038/cdd.2010.129
43. Mosammaparast N, Kim H, Laurent B, et al. The histone demethylase LSD1/KDM1A promotes the DNA damage response. J Cell Biol. 2013;203:457-470. doi:10.1083/jcb.201302092
44. Schäfer A. Gadd45 proteins: Key players of repair-mediated DNA demethylation. Adv Exp Med Biol. 2013;793:35-50. doi:10.1007/978-1-4614-8289-5-3
45. Li Y, Zhao M, Yin H, et al. Overexpression of the growth arrest and DNA damage-induced 45alpha gene contributes to autoimmunity by promoting DNA demethylation in lupus T cells. Arthritis Rheum. 2010;62:1438-1447. doi:10.1002/art.27363
46. Fujiki K, Shinoda A, Kano F, Sato R, Shirahige K, Murata M. PPAR?-induced PARylation promotes local DNA demethylation by production of 5-hydroxymethylcytosine. Nat Commun. 2013;4:2262-2265. doi:10.1038/ncomms3262
47. Paull TT, Rogakou EP, Yamazaki V, Kirchgessner CU, Gellert M, Bonner WM. A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr Biol. 2000;10:886-895.
48. Huen MS, Sy SM, Chen J. BRCA1 and its toolbox for the maintenance of genome integrity. Nat Rev Mol Cell Biol. 2010;11:138-148. doi:10.1038/nrm2831
49. Rodier F, Coppé JP, Patil CK, et al. Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat Cell Biol. 2009;11:973-979. doi:10.1038/ncb1909
50. Tseng SF, Chang CY, Wu KJ, Teng SC. Importin KPNA2 is required for proper nuclear localization and multiple functions of NBS1. J Biol Chem. 2005;280:39594-39600.
51. Kessenbrock K, Plaks V, Werb Z. Matrix metalloproteinases: Regulators of the tumor microenvironment. Cell. 2010;141:52-67. doi:10.1016/j. cell.2010.03.015
52. Serrano M, Lee H, Chin L, Cordon-Cardo C, Beach D, DePinho RA. Role of the INK4a locus in tumor suppression and cell mortality. Cell. 1996;85:27-37.
53. Grover R, Chana JS, Wilson GD, Richman PI, Sanders R. An analysis of p16 protein expression in sporadic malignant melanoma. Melanoma Res. 1998;8:267-272.
54. Chintala SK, Fueyo J, Gomez-Manzano C, et al. Adenovirus-mediated p16/CDKN2 gene transfer suppresses glioma invasion in vitro. Oncogene. 1997;15:2049-2057.
55. Harada H, Nakagawa K, Iwata S, et al. Restoration of wild-type p16 down-regulates vascular endothelial growth factor expression and inhibits angiogenesis in human gliomas. Cancer Res. 1999;59:3783-3789.