Withanone binds to mortalin and abrogates mortalin-p53 complex: Computational and experimental evidence

International Journal of Biochemistry and Cell Biology

Volumn 44, Issue 3, 2012, Pages 496-504

  Grover, Abhinav ^a   Priyandoko, Didik ^b   Gao, Ran ^b   Shandilya, Ashutosh ^a   Widodo, Nashi ^b   Bisaria, Virendra S ^a   Kaul, Sunil C ^b   Wadhwa, Renu ^b   Sundar, Durai ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY DELHI   (India)

^b NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

Author keywords

Cancer; Interaction; Molecular dynamics; Mortalin; p53; p53 activation; Withanone

Indexed keywords

1 ETHYL 2 [[3 ETHYL 5 (3 METHYLBENZOTHIAZOLIN 2 YLIDENE) 4 OXOTHIAZOLIDIN 2 YLIDENE]METHYL]PYRIDINIUM CHLORIDE; MORTALIN; PROTEIN; PROTEIN P53; UNCLASSIFIED DRUG; WITHANOLIDE; WITHANONE;

ARTICLE; CANCER CELL CULTURE; CENTROSOME; COMPLEX FORMATION; CONTROLLED STUDY; DRUG PROTEIN BINDING; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; NUCLEOTIDE SEQUENCE; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; STRUCTURE ANALYSIS; THERMODYNAMICS; TRANSCRIPTION INITIATION;

ACTIVE TRANSPORT, CELL NUCLEUS; CELL NUCLEUS; COMPUTATIONAL BIOLOGY; DRUG SCREENING ASSAYS, ANTITUMOR; HSP70 HEAT-SHOCK PROTEINS; HUMANS; NEOPLASMS; PROTEIN BINDING; TRITERPENES; TUMOR SUPPRESSOR PROTEIN P53; WITHANIA;

EID: 84857232029     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2011.11.021     Document Type: Article

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